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<meta name="keywords" content="C0152018, cancer of esophagus, cancer of the esophagus, carcinoma of esophagus, carcinoma of the esophagus, carcinoma of the oesophagus, esophageal cancer, esophageal carcinoma, esophagus carcinoma, neoplastic process, oesophageal carcinoma, oesophagus carcinoma, autosomal dominant, autosomal recessive, birth defects, chromosomal disease, chromosome, clinical features, clinical findings, clinical genetics, clinical recommendations, clinvar, congenital chromosomal disease, consumer genetic resources, cytogenetic location, disease characteristics, disease definitions, disease descriptions, disease ontology, disease synonyms, disease vocabulary, dysmorphology, entrez, familial disease, gene, gene-disease relationship, genereviews, genetic disease, genetic disorder, genetic terminology, genetic testing registry, genetics home reference, genomic disease, gtr, hereditary disease, heritable disease, hpo, human phenotype ontology, inherited disease, management guidelines, maternal inheritance, medgen, medical genetics, medical subject headings, mesh, mitochondrial inheritance, mode of inheritance, national center for biotechnology information, national institutes of health, national library of medicine, ncbi, nih, nlm, omim, ordo, orphanet, paternal inheritance, phenome, position statements, professional practice guidelines, rare disease, reference sequence, refseq, snomed ct, syndrome, undiagnosed diseases, x-linked recessive" /><meta name="description" content="The presence of a carcinoma of the esophagus." /><meta name="robots" content="index,nofollow,noarchive" />
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<title>Esophageal carcinoma (Concept Id: C0152018)
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<!--
UID=56256
ConceptID=C0152018
-->
<!--imgCountBooks = 0--><h1 class="medgenTitle"><div class="MedGenTitleText">Esophageal carcinoma</div></h1><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>56256</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information."><span class="highlight" style="background-color:">C0152018</span></a></dd><dt><span class="dotprefix"></span></dt><dd>Neoplastic Process</dd></dl></div></div><table class="medgenTable"><tbody><tr><td>Synonyms:</td>
<td>Carcinoma of esophagus; Oesophageal carcinoma</td></tr>
<tr><td><span class="bold">SNOMED CT: </span></td>
<td>Carcinoma of esophagus (372138000)</td></tr>
<tr><td colspan="2" class="small"> </td></tr><tr><td>HPO:</td>
<td><a target="_blank" title="Human Phenotype Ontology" href="https://hpo.jax.org/app/browse/term/HP:0011459">HP:0011459</a></td></tr>
<tr><td>Monarch Initiative:</td>
<td><a href="https://monarchinitiative.org/disease/MONDO:0019086" target="_blank">MONDO:0019086</a></td></tr>
<tr><td>OMIM<span class="superscript">®</span>:</td>
<td><a href="https://omim.org/entry/133239" target="_blank">133239</a></td></tr>
<tr><td>Orphanet:</td>
<td><a target="_blank" title="Orphanet: The portal for rare diseases and orphan drugs" href="http://www.orpha.net/consor/cgi-bin/OC_Exp.php?lng=EN&amp;Expert=70482">ORPHA70482</a></td></tr></tbody></table></div><div class="rprt-body jig-ncbiinpagenav" data-jigconfig="smoothScroll: false, gotoTopLink: true, gotoTopLinkText: '', gotoTopLinkAttrs: {'title': 'Go to the top of the page'},allHeadingLevels: ['h1'], topOfPageTOC: true, tocId: 'my-toc'"><div id="rprt-tabs-1" class="rprt-tab"><div id="tb-termsProp-1"><div class="leftCol mgCol"><div>
<div class="portlet mgSection" id="ID_100">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Definition">Definition</h1><a sid="100" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln">The presence of a carcinoma of the esophagus. [from <a title="Human Phenotype Ontology" href="http://www.human-phenotype-ontology.org" class="defSource" target="_blank">HPO</a>]</div>
</div>
<div class="portlet mgSection" id="ID_118">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Term_Hierarchy">Term Hierarchy</h1><a sid="118" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln HierarchyGTR"><div class="jig-ncbitabs"><ul><li><a href="#tabGTR">GTR</a></li><li><a href="#tabMGEN">MeSH</a></li><li><a href="#tabORDO">Orphanet</a></li></ul><div id="tabGTR"><div class="search_result"><div class="rprts"><div class="chiclet_legend"><span class="chiclet_list" style="position:static;"><span title="Clinical test" class="chiclet Ccolor round">C</span><span>Clinical test,  </span><span title="Research test" class="chiclet Rcolor round">R</span><span>Research test,  </span><span title="OMIM" class="chiclet Ocolor ">O</span><span>OMIM,  </span><span title="GeneReview" class="chiclet Gcolor">G</span><span><em>GeneReviews</em>,  </span><span title="ClinVar" class="chiclet Vcolor">V</span><span>ClinVar  </span></span></div><div id="hierarchy" class="margin_t1"><div class="ds_tree"><ul><li class="matched_ds"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C0152018[DISCUI]&amp;test_type=Clinical" ref="ncbi_uid=56256">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet Ocolor" title="OMIM"><a ref="ncbi_uid=56256" target="_blank" href="/omim/133239">O</a></span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&amp;from_uid=56256" ref="ncbi_uid=56256">V</a></span></span><span class="TLline">Esophageal carcinoma</span></li></ul></div></div></div></div></div><div id="tabMGEN"><div class="ds_tree"><ul><li><span class="TLline"><a href="/medgen/18325" ref="tree=MeSH" title="MedGen record for Pathological process">Pathological process</a></span><ul><li><span class="TLline"><a href="/medgen/4347" ref="tree=MeSH" title="MedGen record for Disease">Disease</a></span><ul><li><span class="TLline"><a href="/medgen/10294" ref="tree=MeSH" title="MedGen record for Neoplasm">Neoplasm</a></span><ul><li><span class="TLline"><a href="/medgen/277963" ref="tree=MeSH" title="MedGen record for Epithelial neoplasm">Epithelial neoplasm</a></span><ul><li><span class="TLline"><a href="/medgen/2867" ref="tree=MeSH" title="MedGen record for Carcinoma">Carcinoma</a></span><ul><li><span class="TLline"><a href="/medgen/57467" ref="tree=MeSH" title="MedGen record for Gastrointestinal carcinoma">Gastrointestinal carcinoma</a></span><ul><li><span class="matched_ds">Esophageal carcinoma</span><ul><li><span class="TLline"><a href="/medgen/124636" ref="tree=MeSH" title="MedGen record for Adenocarcinoma of esophagus">Adenocarcinoma of esophagus</a></span><ul><li><span class="TLline"><a href="/medgen/1657931" ref="tree=MeSH" title="MedGen record for Cervical Esophagus Adenocarcinoma">Cervical Esophagus Adenocarcinoma</a></span></li><li><span class="TLline"><a href="/medgen/1650160" ref="tree=MeSH" title="MedGen record for Distal Esophagus Adenocarcinoma">Distal Esophagus Adenocarcinoma</a></span><ul><li><span class="TLline"><a href="/medgen/272350" ref="tree=MeSH" title="MedGen record for Barrett adenocarcinoma">Barrett adenocarcinoma</a></span></li><li><span class="TLline"><a href="/medgen/1724679" ref="tree=MeSH" title="MedGen record for Metastatic Distal Esophagus Adenocarcinoma">Metastatic Distal Esophagus Adenocarcinoma</a></span></li><li><span class="TLline"><a href="/medgen/1769328" ref="tree=MeSH" title="MedGen record for Unresectable Distal Esophagus Adenocarcinoma">Unresectable Distal Esophagus Adenocarcinoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/1621854" ref="tree=MeSH" title="MedGen record for Esophageal Adenocarcinoma by AJCC v7 Stage">Esophageal Adenocarcinoma by AJCC v7 Stage</a></span><ul><li><span class="TLline"><a href="/medgen/1658142" ref="tree=MeSH" title="MedGen record for Stage 0 Esophageal Adenocarcinoma AJCC v7">Stage 0 Esophageal Adenocarcinoma AJCC v7</a></span></li><li><span class="TLline"><a href="/medgen/1667093" ref="tree=MeSH" title="MedGen record for Stage I Esophageal Adenocarcinoma AJCC v7">Stage I Esophageal Adenocarcinoma AJCC v7</a></span></li><li><span class="TLline"><a href="/medgen/1666561" ref="tree=MeSH" title="MedGen record for Stage II Esophageal Adenocarcinoma AJCC v7">Stage II Esophageal Adenocarcinoma AJCC v7</a></span></li><li><span class="TLline"><a href="/medgen/1666943" ref="tree=MeSH" title="MedGen record for Stage III Esophageal Adenocarcinoma AJCC v7">Stage III Esophageal Adenocarcinoma AJCC v7</a></span></li><li><span class="TLline"><a href="/medgen/1658676" ref="tree=MeSH" title="MedGen record for Stage IV Esophageal Adenocarcinoma AJCC v7">Stage IV Esophageal Adenocarcinoma AJCC v7</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/1617662" ref="tree=MeSH" title="MedGen record for Esophageal Adenocarcinoma by AJCC v8 Stage">Esophageal Adenocarcinoma by AJCC v8 Stage</a></span><ul><li><span class="TLline"><a href="/medgen/1620259" ref="tree=MeSH" title="MedGen record for Esophageal Adenocarcinoma by AJCC v8 Clinical Stage">Esophageal Adenocarcinoma by AJCC v8 Clinical Stage</a></span></li><li><span class="TLline"><a href="/medgen/1612620" ref="tree=MeSH" title="MedGen record for Esophageal Adenocarcinoma by AJCC v8 Pathologic Stage">Esophageal Adenocarcinoma by AJCC v8 Pathologic Stage</a></span></li><li><span class="TLline"><a href="/medgen/1622506" ref="tree=MeSH" title="MedGen record for Esophageal Adenocarcinoma by AJCC v8 Postneoadjuvant Therapy Stage">Esophageal Adenocarcinoma by AJCC v8 Postneoadjuvant Therapy Stage</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/1698382" ref="tree=MeSH" title="MedGen record for Esophageal Intramucosal Adenocarcinoma">Esophageal Intramucosal Adenocarcinoma</a></span></li><li><span class="TLline"><a href="/medgen/216043" ref="tree=MeSH" title="MedGen record for Metastatic Esophageal Adenocarcinoma">Metastatic Esophageal Adenocarcinoma</a></span><ul><li><span class="TLline"><a href="/medgen/1715271" ref="tree=MeSH" title="MedGen record for Advanced Esophageal Adenocarcinoma">Advanced Esophageal Adenocarcinoma</a></span></li><li><span class="TLline"><a href="/medgen/1750366" ref="tree=MeSH" title="MedGen record for Locally Advanced Esophageal Adenocarcinoma">Locally Advanced Esophageal Adenocarcinoma</a></span></li><li><span class="TLline"><a href="/medgen/1709233" ref="tree=MeSH" title="MedGen record for Oligometastatic Esophageal Adenocarcinoma">Oligometastatic Esophageal Adenocarcinoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/167707" ref="tree=MeSH" title="MedGen record for Recurrent Esophageal Adenocarcinoma">Recurrent Esophageal Adenocarcinoma</a></span></li><li><span class="TLline"><a href="/medgen/1779223" ref="tree=MeSH" title="MedGen record for Refractory Esophageal Adenocarcinoma">Refractory Esophageal Adenocarcinoma</a></span></li><li><span class="TLline"><a href="/medgen/1665639" ref="tree=MeSH" title="MedGen record for Thoracic Esophagus Adenocarcinoma">Thoracic Esophagus Adenocarcinoma</a></span></li><li><span class="TLline"><a href="/medgen/1734740" ref="tree=MeSH" title="MedGen record for Unresectable Esophageal Adenocarcinoma">Unresectable Esophageal Adenocarcinoma</a></span><ul><li><span class="TLline"><a href="/medgen/1695489" ref="tree=MeSH" title="MedGen record for Locally Advanced Unresectable Esophageal Adenocarcinoma">Locally Advanced Unresectable Esophageal Adenocarcinoma</a></span></li></ul></li></ul></li><li><span class="TLline"><a href="/medgen/1678006" ref="tree=MeSH" title="MedGen record for Carcinoma of esophagus, salivary gland type">Carcinoma of esophagus, salivary gland type</a></span></li><li><span class="TLline"><a href="/medgen/859258" ref="tree=MeSH" title="MedGen record for Childhood Esophageal Carcinoma">Childhood Esophageal Carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/232468" ref="tree=MeSH" title="MedGen record for Esophageal adenoid cystic carcinoma">Esophageal adenoid cystic carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/389165" ref="tree=MeSH" title="MedGen record for Esophageal adenosquamous carcinoma">Esophageal adenosquamous carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/455928" ref="tree=MeSH" title="MedGen record for Esophageal Cancer by AJCC v6 Stage">Esophageal Cancer by AJCC v6 Stage</a></span><ul><li><span class="TLline"><a href="/medgen/453387" ref="tree=MeSH" title="MedGen record for Stage 0 Esophageal Cancer AJCC v6">Stage 0 Esophageal Cancer AJCC v6</a></span></li><li><span class="TLline"><a href="/medgen/124472" ref="tree=MeSH" title="MedGen record for Stage I Esophageal Cancer AJCC v6">Stage I Esophageal Cancer AJCC v6</a></span></li><li><span class="TLline"><a href="/medgen/82942" ref="tree=MeSH" title="MedGen record for Stage II Esophageal Cancer AJCC v6">Stage II Esophageal Cancer AJCC v6</a></span></li><li><span class="TLline"><a href="/medgen/75835" ref="tree=MeSH" title="MedGen record for Stage III Esophageal Cancer AJCC v6">Stage III Esophageal Cancer AJCC v6</a></span></li><li><span class="TLline"><a href="/medgen/234612" ref="tree=MeSH" title="MedGen record for Stage IV Esophageal Cancer AJCC v6">Stage IV Esophageal Cancer AJCC v6</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/456312" ref="tree=MeSH" title="MedGen record for Esophageal Cancer by AJCC v7 Stage">Esophageal Cancer by AJCC v7 Stage</a></span><ul><li><span class="TLline"><a href="/medgen/1616131" ref="tree=MeSH" title="MedGen record for Esophageal Squamous Cell Carcinoma by AJCC v7 Stage">Esophageal Squamous Cell Carcinoma by AJCC v7 Stage</a></span><ul><li><span class="TLline"><a href="/medgen/1665436" ref="tree=MeSH" title="MedGen record for Stage 0 Esophageal Squamous Cell Carcinoma AJCC v7">Stage 0 Esophageal Squamous Cell Carcinoma AJCC v7</a></span></li><li><span class="TLline"><a href="/medgen/1670269" ref="tree=MeSH" title="MedGen record for Stage I Esophageal Squamous Cell Carcinoma AJCC v7">Stage I Esophageal Squamous Cell Carcinoma AJCC v7</a></span></li><li><span class="TLline"><a href="/medgen/1663911" ref="tree=MeSH" title="MedGen record for Stage II Esophageal Squamous Cell Carcinoma AJCC v7">Stage II Esophageal Squamous Cell Carcinoma AJCC v7</a></span></li><li><span class="TLline"><a href="/medgen/1656563" ref="tree=MeSH" title="MedGen record for Stage III Esophageal Squamous Cell Carcinoma AJCC v7">Stage III Esophageal Squamous Cell Carcinoma AJCC v7</a></span></li><li><span class="TLline"><a href="/medgen/1661161" ref="tree=MeSH" title="MedGen record for Stage IV Esophageal Squamous Cell Carcinoma AJCC v7">Stage IV Esophageal Squamous Cell Carcinoma AJCC v7</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/1625333" ref="tree=MeSH" title="MedGen record for Stage 0 Esophageal Cancer AJCC v7">Stage 0 Esophageal Cancer AJCC v7</a></span></li><li><span class="TLline"><a href="/medgen/459996" ref="tree=MeSH" title="MedGen record for Stage I Esophageal Cancer AJCC v7">Stage I Esophageal Cancer AJCC v7</a></span><ul><li><span class="TLline"><a href="/medgen/857135" ref="tree=MeSH" title="MedGen record for Stage IA Esophageal Cancer AJCC v7">Stage IA Esophageal Cancer AJCC v7</a></span></li><li><span class="TLline"><a href="/medgen/857134" ref="tree=MeSH" title="MedGen record for Stage IB Esophageal Cancer AJCC v7">Stage IB Esophageal Cancer AJCC v7</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/459995" ref="tree=MeSH" title="MedGen record for Stage II Esophageal Cancer AJCC v7">Stage II Esophageal Cancer AJCC v7</a></span><ul><li><span class="TLline"><a href="/medgen/277685" ref="tree=MeSH" title="MedGen record for Stage IIA Esophageal Cancer AJCC v7">Stage IIA Esophageal Cancer AJCC v7</a></span></li><li><span class="TLline"><a href="/medgen/236875" ref="tree=MeSH" title="MedGen record for Stage IIB Esophageal Cancer AJCC v7">Stage IIB Esophageal Cancer AJCC v7</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/459994" ref="tree=MeSH" title="MedGen record for Stage III Esophageal Cancer AJCC v7">Stage III Esophageal Cancer AJCC v7</a></span><ul><li><span class="TLline"><a href="/medgen/856678" ref="tree=MeSH" title="MedGen record for Stage IIIA Esophageal Cancer AJCC v7">Stage IIIA Esophageal Cancer AJCC v7</a></span></li><li><span class="TLline"><a href="/medgen/857124" ref="tree=MeSH" title="MedGen record for Stage IIIB Esophageal Cancer AJCC v7">Stage IIIB Esophageal Cancer AJCC v7</a></span></li><li><span class="TLline"><a href="/medgen/857121" ref="tree=MeSH" title="MedGen record for Stage IIIC Esophageal Cancer AJCC v7">Stage IIIC Esophageal Cancer AJCC v7</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/1655825" ref="tree=MeSH" title="MedGen record for Stage IV Esophageal Cancer AJCC v7">Stage IV Esophageal Cancer AJCC v7</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/1615347" ref="tree=MeSH" title="MedGen record for Esophageal Cancer by AJCC v8 Stage">Esophageal Cancer by AJCC v8 Stage</a></span><ul><li><span class="TLline"><a href="/medgen/1613217" ref="tree=MeSH" title="MedGen record for Esophageal Squamous Cell Carcinoma by AJCC v8 Stage">Esophageal Squamous Cell Carcinoma by AJCC v8 Stage</a></span><ul><li><span class="TLline"><a href="/medgen/1623902" ref="tree=MeSH" title="MedGen record for Esophageal Squamous Cell Carcinoma by AJCC v8 Clinical Stage">Esophageal Squamous Cell Carcinoma by AJCC v8 Clinical Stage</a></span></li><li><span class="TLline"><a href="/medgen/1617526" ref="tree=MeSH" title="MedGen record for Esophageal Squamous Cell Carcinoma by AJCC v8 Pathologic Stage">Esophageal Squamous Cell Carcinoma by AJCC v8 Pathologic Stage</a></span></li><li><span class="TLline"><a href="/medgen/1614636" ref="tree=MeSH" title="MedGen record for Esophageal Squamous Cell Carcinoma by AJCC v8 Postneoadjuvant Therapy Stage">Esophageal Squamous Cell Carcinoma by AJCC v8 Postneoadjuvant Therapy Stage</a></span></li></ul></li></ul></li><li><span class="TLline"><a href="/medgen/459490" ref="tree=MeSH" title="MedGen record for Esophageal Mixed Adenoneuroendocrine Carcinoma">Esophageal Mixed Adenoneuroendocrine Carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/459488" ref="tree=MeSH" title="MedGen record for Esophageal Neuroendocrine Carcinoma">Esophageal Neuroendocrine Carcinoma</a></span><ul><li><span class="TLline"><a href="/medgen/459489" ref="tree=MeSH" title="MedGen record for Esophageal Large Cell Neuroendocrine Carcinoma">Esophageal Large Cell Neuroendocrine Carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/207270" ref="tree=MeSH" title="MedGen record for Esophageal small cell neuroendocrine carcinoma">Esophageal small cell neuroendocrine carcinoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/124635" ref="tree=MeSH" title="MedGen record for Esophageal squamous cell carcinoma">Esophageal squamous cell carcinoma</a></span><ul><li><span class="TLline"><a href="/medgen/231048" ref="tree=MeSH" title="MedGen record for Alcohol-Related Esophageal Squamous Cell Carcinoma">Alcohol-Related Esophageal Squamous Cell Carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/1651886" ref="tree=MeSH" title="MedGen record for Cervical Esophagus Squamous Cell Carcinoma">Cervical Esophagus Squamous Cell Carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/1668587" ref="tree=MeSH" title="MedGen record for Distal Esophagus Squamous Cell Carcinoma">Distal Esophagus Squamous Cell Carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/232156" ref="tree=MeSH" title="MedGen record for Esophageal basaloid carcinoma">Esophageal basaloid carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/459481" ref="tree=MeSH" title="MedGen record for Esophageal Moderately Differentiated Squamous Cell Carcinoma">Esophageal Moderately Differentiated Squamous Cell Carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/459482" ref="tree=MeSH" title="MedGen record for Esophageal Poorly Differentiated Squamous Cell Carcinoma">Esophageal Poorly Differentiated Squamous Cell Carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/459478" ref="tree=MeSH" title="MedGen record for Esophageal Spindle Cell Carcinoma">Esophageal Spindle Cell Carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/459480" ref="tree=MeSH" title="MedGen record for Esophageal Well Differentiated Squamous Cell Carcinoma">Esophageal Well Differentiated Squamous Cell Carcinoma</a></span><ul><li><span class="TLline"><a href="/medgen/1792372" ref="tree=MeSH" title="MedGen record for Esophageal Carcinoma Cuniculatum">Esophageal Carcinoma Cuniculatum</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/272594" ref="tree=MeSH" title="MedGen record for Esophagus verrucous carcinoma">Esophagus verrucous carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/232618" ref="tree=MeSH" title="MedGen record for Human Papillomavirus-Related Esophageal Squamous Cell Carcinoma">Human Papillomavirus-Related Esophageal Squamous Cell Carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/222971" ref="tree=MeSH" title="MedGen record for Metastatic Esophageal Squamous Cell Carcinoma">Metastatic Esophageal Squamous Cell Carcinoma</a></span><ul><li><span class="TLline"><a href="/medgen/1757946" ref="tree=MeSH" title="MedGen record for Advanced Esophageal Squamous Cell Carcinoma">Advanced Esophageal Squamous Cell Carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/1745399" ref="tree=MeSH" title="MedGen record for Locally Advanced Esophageal Squamous Cell Carcinoma">Locally Advanced Esophageal Squamous Cell Carcinoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/163455" ref="tree=MeSH" title="MedGen record for Recurrent Esophageal Squamous Cell Carcinoma">Recurrent Esophageal Squamous Cell Carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/1734187" ref="tree=MeSH" title="MedGen record for Refractory Esophageal Squamous Cell Carcinoma">Refractory Esophageal Squamous Cell Carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/1665515" ref="tree=MeSH" title="MedGen record for Thoracic Esophagus Squamous Cell Carcinoma">Thoracic Esophagus Squamous Cell Carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/1723894" ref="tree=MeSH" title="MedGen record for Unresectable Esophageal Squamous Cell Carcinoma">Unresectable Esophageal Squamous Cell Carcinoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/1711643" ref="tree=MeSH" title="MedGen record for Localized Esophageal Carcinoma">Localized Esophageal Carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/1667581" ref="tree=MeSH" title="MedGen record for Metastatic Esophageal Carcinoma">Metastatic Esophageal Carcinoma</a></span><ul><li><span class="TLline"><a href="/medgen/1705531" ref="tree=MeSH" title="MedGen record for Advanced Esophageal Carcinoma">Advanced Esophageal Carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/1718968" ref="tree=MeSH" title="MedGen record for Locally Advanced Esophageal Carcinoma">Locally Advanced Esophageal Carcinoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/234232" ref="tree=MeSH" title="MedGen record for Mucoepidermoid esophageal carcinoma">Mucoepidermoid esophageal carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/163142" ref="tree=MeSH" title="MedGen record for Recurrent Esophageal Carcinoma">Recurrent Esophageal Carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/1755850" ref="tree=MeSH" title="MedGen record for Refractory Esophageal Carcinoma">Refractory Esophageal Carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/412163" ref="tree=MeSH" title="MedGen record for Undifferentiated carcinoma of esophagus">Undifferentiated carcinoma of esophagus</a></span></li><li><span class="TLline"><a href="/medgen/922955" ref="tree=MeSH" title="MedGen record for Unresectable Esophageal Carcinoma">Unresectable Esophageal Carcinoma</a></span></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></div></div><div id="tabORDO">Follow <a target="_blank" href="http://www.orpha.net/consor/cgi-bin/Disease_Classif.php?lng=EN&amp;data_id=156&amp;PatId=10950&amp;search=Disease_Classif_Simple&amp;new=1" class="ital bold">this link</a> to review classifications for <span class="ital">Esophageal carcinoma</span> in Orphanet.</div></div></div>
</div>
<div class="portlet mgSection" id="ID_112">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Conditions_with_this_feature">Conditions with this feature</h1><a sid="112" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln clinfeat">
<div class="divPopper rprt" id="rdis_2551"><div><strong>Barrett esophagus</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>2551</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C0004763</a></dd><dt><span class="dotprefix"></span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
<div class="spaceAbove">Barrett esophagus, or Barrett metaplasia, describes the phenotypic change of normal esophageal squamous epithelium to a columnar and intestinal-type epithelium. This metaplastic change is important because patients with Barrett esophagus have an increased risk of esophageal adenocarcinoma. The main cause of Barrett metaplasia is gastroesophageal reflux (GER; 109350). The retrograde movement of acid and bile salts from the stomach into the esophagus in this disease causes prolonged injury to the esophageal epithelium and induces chronic esophagitis, which in turn is believed to trigger the pathologic changes (summary by Wong et al., 2005).</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/2551">Condition Record</a></div></div>
<div class="divPopper rprt" id="rdis_107792"><div><strong>Malignant tumor of esophagus</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>107792</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C0546837</a></dd><dt><span class="dotprefix"></span></dt><dd>Neoplastic Process</dd></dl></div></div></div>
<div class="spaceAbove">Esophageal cancer, particularly esophageal squamous cell carcinoma (ESCC), is one of the most common cancers worldwide. Both environmental and genetic risk factors play a role in the pathogenesis of the disorder. In Europe and North America, heavy smoking, alcohol consumption, and increased body mass index (BMI) are the main environmental risk factors. In contrast, the particularly high incidence of ESCC in some areas of China, central Asia, and southern Africa is associated with nutritional deficiencies, high intake of nitrosamine-rich or pickled vegetables, and low socioeconomic status; smoking, alcohol consumption, and BMI play a lesser role in these populations. There is a tendency for familial aggregation of ESCC in high-risk geographic areas, suggesting a genetic component to increased susceptibility. Gastric cardia adenocarcinoma is another common type of cancer in China that shows similarities to ESCC in terms of geographic distribution and environmental risk factors (summary by Wang et al., 2010 and Abnet et al., 2010).&#13; Genetic Heterogeneity of Susceptibility to Esophageal Cancer&#13; See a variant in the ADH1B gene (103720.0001) for discussion of a possible genetic association with protection against squamous cell aerodigestive tract cancer, including esophageal cancer, in alcohol drinkers. See a variant in the ALDH2 gene (100650.0001) for discussion of a possible genetic association with increased risk for esophageal cancer in alcohol drinkers due to interaction between variants in the ADH1B and ALDH2 genes.&#13; See the S100A14 gene (607986) on chromosome 1q21 for a discussion of a possible association between variation in that gene and susceptibility to esophageal squamous cell carcinoma among smokers.&#13; Genetic Heterogeneity of Somatic Mutations in Esophageal Cancer&#13; Somatic mutations in several different genes have been found in esophageal cancer tissue. These genes include TP53 (191170), CDKN2A (600160), DEC1 (604767), DCC (120470), DLEC1 (604050), TGFBR2 (190182), LZTS1 (606551), RNF6 (604242), WWOX (605131), APC (611731), and RUNX3 (600210).</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/107792">Condition Record</a></div></div>
<div class="divPopper rprt" id="rdis_324338"><div><strong>Palmoplantar keratoderma-esophageal carcinoma syndrome</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>324338</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C1835664</a></dd><dt><span class="dotprefix"></span></dt><dd>Neoplastic Process</dd></dl></div></div></div>
<div class="spaceAbove">Tylosis with esophageal cancer (TOC) is an autosomal dominant syndrome characterized by palmoplantar keratoderma (PPK; see 600962 and 144200), oral precursor lesions, and a high lifetime risk of esophageal cancer (summary by Blaydon et al., 2012).</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/324338">Condition Record</a></div></div>
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_2551" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Barrett esophagus</a></div>
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_107792" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Malignant tumor of esophagus</a></div>
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_324338" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Palmoplantar keratoderma-esophageal carcinoma syndrome</a></div></div>
</div>
<div class="portlet mgSection" id="ID_105">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Professional_guidelines">Professional guidelines</h1><a sid="105" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln"><h3 class="subhead">PubMed<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpPM"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3>
<div class="nl"><a target="_blank" href="/pubmed/26185366">Esophageal cancer: Risk factors, screening and endoscopic treatment in Western and Eastern countries.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Domper Arnal MJ,
Ferrández Arenas Á,
Lanas Arbeloa Á</span><br />
<span class="medgenPMjournal">World J Gastroenterol</span>
2015 Jul 14;21(26):7933-43.
doi: 10.3748/wjg.v21.i26.7933.
<span class="bold">PMID: </span><a href="/pubmed/26185366" target="_blank">26185366</a><a href="/pmc/articles/PMC4499337" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/25250506">Undervalued criteria in the evaluation of multimodal trials for upper GI cancers.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Brücher BL,
Kitajima M,
Siewert JR</span><br />
<span class="medgenPMjournal">Cancer Invest</span>
2014 Dec;32(10):497-506.
Epub 2014 Sep 24
doi: 10.3109/07357907.2014.958497.
<span class="bold">PMID: </span><a href="/pubmed/25250506" target="_blank">25250506</a><a href="/pmc/articles/PMC4266078" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/15887129">American Gastroenterological Association technical review on the role of the gastroenterologist in the management of esophageal carcinoma.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Wang KK,
Wongkeesong M,
Buttar NS</span><br />
<span class="medgenPMjournal">Gastroenterology</span>
2005 May;128(5):1471-505.
doi: 10.1053/j.gastro.2005.03.077.
<span class="bold">PMID: </span><a href="/pubmed/15887129" target="_blank">15887129</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(%22esophageal%20carcinoma%22%5Btiab%3A~0%5D)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">See all (271)</a></div></div>
</div>
<div class="display-none help-popup" id="guidelinesHelpPM">These guidelines are articles in PubMed that match specific search criteria developed by MedGen to capture the most relevant practice guidelines. This list may not be comprehensive and may include broader topics as well. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div><div class="display-none help-popup" id="guidelinesHelpCurated">These guidelines are manually curated by the MedGen team
to supplement articles available in PubMed. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div>
<div class="portlet mgSection" id="ID_103">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_clinical_studies">Recent clinical studies</h1><a sid="103" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln"><h3 class="subhead">Etiology</h3>
<div class="nl"><a target="_blank" href="/pubmed/38292873">Survival benefit of combined immunotherapy and chemoradiotherapy in locally advanced unresectable esophageal cancer: an analysis based on the SEER database.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Xie L,
Zhang Z</span><br />
<span class="medgenPMjournal">Front Immunol</span>
2024;15:1334992.
Epub 2024 Jan 16
doi: 10.3389/fimmu.2024.1334992.
<span class="bold">PMID: </span><a href="/pubmed/38292873" target="_blank">38292873</a><a href="/pmc/articles/PMC10825045" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/38116684">Does surgery and radiotherapy really improve the prognosis of patients with small-cell esophageal carcinoma?</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Li K,
Mao J,
Huang Y</span><br />
<span class="medgenPMjournal">Int J Surg</span>
2024 Mar 1;110(3):1882-1883.
doi: 10.1097/JS9.0000000000001020.
<span class="bold">PMID: </span><a href="/pubmed/38116684" target="_blank">38116684</a><a href="/pmc/articles/PMC10942178" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/37915027">Survival outcomes of esophageal cancer patients with recurrence after curative treatments.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Sugawara K,
Oka D,
Hara H,
Yoshii T,
Ushijima H,
Kudo S,
Fukuda T</span><br />
<span class="medgenPMjournal">BMC Cancer</span>
2023 Nov 1;23(1):1051.
doi: 10.1186/s12885-023-11568-w.
<span class="bold">PMID: </span><a href="/pubmed/37915027" target="_blank">37915027</a><a href="/pmc/articles/PMC10619310" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/33907054">Esophageal Cancer Surgery in Dialyzed Patients: A Single Institution Case Series.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Urabe M,
Ueno M,
Yago A,
Shimoyama H,
Ohkura Y,
Haruta S,
Udagawa H</span><br />
<span class="medgenPMjournal">Ann Thorac Cardiovasc Surg</span>
2022 Oct 20;28(5):366-370.
Epub 2021 Apr 27
doi: 10.5761/atcs.cr.20-00361.
<span class="bold">PMID: </span><a href="/pubmed/33907054" target="_blank">33907054</a><a href="/pmc/articles/PMC9585335" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/9165327">Esophageal varices obliterated by photodynamic therapy for coexisting early esophageal carcinoma.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Ido K,
Yamamoto H,
Kawamoto C,
Koiwai H,
Yoshida Y,
Kimura K</span><br />
<span class="medgenPMjournal">Gastrointest Endosc</span>
1997 May;45(5):420-3.
doi: 10.1016/s0016-5107(97)70156-1.
<span class="bold">PMID: </span><a href="/pubmed/9165327" target="_blank">9165327</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Esophageal%20carcinoma%22%20AND%20Etiology%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (2207)</a></div><h3 class="subhead">Diagnosis</h3>
<div class="nl"><a target="_blank" href="/pubmed/34695406">Diffuse and Nodular Pericardial Metastases From Esophageal Carcinoma.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Jiang M,
Chen P,
Zhao G,
Zheng J</span><br />
<span class="medgenPMjournal">Ann Thorac Surg</span>
2022 Feb;113(2):e155.
Epub 2021 Oct 22
doi: 10.1016/j.athoracsur.2021.09.042.
<span class="bold">PMID: </span><a href="/pubmed/34695406" target="_blank">34695406</a></div>
<div class="nl"><a target="_blank" href="/pubmed/30166051">Hyponatremia Complicating Esophageal Carcinoma: A Challenging Differential Diagnosis.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Mackelaite L,
Lederer E</span><br />
<span class="medgenPMjournal">Am J Med Sci</span>
2018 Dec;356(6):567-569.
Epub 2018 Jun 6
doi: 10.1016/j.amjms.2018.05.014.
<span class="bold">PMID: </span><a href="/pubmed/30166051" target="_blank">30166051</a></div>
<div class="nl"><a target="_blank" href="/pubmed/7583037">Transhiatal esophagectomy.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Zwischenberger JB,
Sankar AB</span><br />
<span class="medgenPMjournal">Chest Surg Clin N Am</span>
1995 Aug;5(3):527-42.
<span class="bold">PMID: </span><a href="/pubmed/7583037" target="_blank">7583037</a></div>
<div class="nl"><a target="_blank" href="/pubmed/2643274">Dysphagia.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Bruckstein AH</span><br />
<span class="medgenPMjournal">Am Fam Physician</span>
1989 Jan;39(1):147-56.
<span class="bold">PMID: </span><a href="/pubmed/2643274" target="_blank">2643274</a></div>
<div class="nl"><a target="_blank" href="/pubmed/6365514">Esophageal carcinoma.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Kreutzer EW</span><br />
<span class="medgenPMjournal">Ear Nose Throat J</span>
1984 Jan;63(1):48-51.
<span class="bold">PMID: </span><a href="/pubmed/6365514" target="_blank">6365514</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Esophageal%20carcinoma%22%20AND%20Diagnosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (1492)</a></div><h3 class="subhead">Therapy</h3>
<div class="nl"><a target="_blank" href="/pubmed/38789200">Immune Checkpoint Inhibitors in Esophageal Carcinoma: Assessment of Efficacy Predictors of Response in Clinical Trials.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Abushukair H,
Abushukair A,
Singh M,
Saeed A</span><br />
<span class="medgenPMjournal">Surg Oncol Clin N Am</span>
2024 Jul;33(3):583-593.
Epub 2024 Jan 20
doi: 10.1016/j.soc.2023.12.024.
<span class="bold">PMID: </span><a href="/pubmed/38789200" target="_blank">38789200</a></div>
<div class="nl"><a target="_blank" href="/pubmed/38729086">Toxicity of immunotherapy combinations with chemotherapy across tumor indications: Current knowledge and practical recommendations.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Rached L,
Laparra A,
Sakkal M,
Danlos FX,
Barlesi F,
Carbonnel F,
De Martin E,
Ducreux M,
Even C,
Le Pavec J,
Michot JM,
M Ribeiro J,
Scotte F,
Ponce Aix S,
Lambotte O,
Baldini C,
Champiat S</span><br />
<span class="medgenPMjournal">Cancer Treat Rev</span>
2024 Jun;127:102751.
Epub 2024 May 4
doi: 10.1016/j.ctrv.2024.102751.
<span class="bold">PMID: </span><a href="/pubmed/38729086" target="_blank">38729086</a></div>
<div class="nl"><a target="_blank" href="/pubmed/34519801">Effect of Camrelizumab vs Placebo Added to Chemotherapy on Survival and Progression-Free Survival in Patients With Advanced or Metastatic Esophageal Squamous Cell Carcinoma: The ESCORT-1st Randomized Clinical Trial.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Luo H,
Lu J,
Bai Y,
Mao T,
Wang J,
Fan Q,
Zhang Y,
Zhao K,
Chen Z,
Gao S,
Li J,
Fu Z,
Gu K,
Liu Z,
Wu L,
Zhang X,
Feng J,
Niu Z,
Ba Y,
Zhang H,
Liu Y,
Zhang L,
Min X,
Huang J,
Cheng Y,
Wang D,
Shen Y,
Yang Q,
Zou J,
Xu RH;
ESCORT-1st Investigators</span><br />
<span class="medgenPMjournal">JAMA</span>
2021 Sep 14;326(10):916-925.
doi: 10.1001/jama.2021.12836.
<span class="bold">PMID: </span><a href="/pubmed/34519801" target="_blank">34519801</a><a href="/pmc/articles/PMC8441593" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/33533655">KEYNOTE-975 study design: a Phase III study of definitive chemoradiotherapy plus pembrolizumab in patients with esophageal carcinoma.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Shah MA,
Bennouna J,
Doi T,
Shen L,
Kato K,
Adenis A,
Mamon HJ,
Moehler M,
Fu X,
Cho BC,
Bordia S,
Bhagia P,
Shih CS,
Desai A,
Enzinger P</span><br />
<span class="medgenPMjournal">Future Oncol</span>
2021 Apr;17(10):1143-1153.
Epub 2021 Feb 3
doi: 10.2217/fon-2020-0969.
<span class="bold">PMID: </span><a href="/pubmed/33533655" target="_blank">33533655</a><a href="/pmc/articles/PMC7927908" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/25250506">Undervalued criteria in the evaluation of multimodal trials for upper GI cancers.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Brücher BL,
Kitajima M,
Siewert JR</span><br />
<span class="medgenPMjournal">Cancer Invest</span>
2014 Dec;32(10):497-506.
Epub 2014 Sep 24
doi: 10.3109/07357907.2014.958497.
<span class="bold">PMID: </span><a href="/pubmed/25250506" target="_blank">25250506</a><a href="/pmc/articles/PMC4266078" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Esophageal%20carcinoma%22%20AND%20Therapy%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (1347)</a></div><h3 class="subhead">Prognosis</h3>
<div class="nl"><a target="_blank" href="/pubmed/38116684">Does surgery and radiotherapy really improve the prognosis of patients with small-cell esophageal carcinoma?</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Li K,
Mao J,
Huang Y</span><br />
<span class="medgenPMjournal">Int J Surg</span>
2024 Mar 1;110(3):1882-1883.
doi: 10.1097/JS9.0000000000001020.
<span class="bold">PMID: </span><a href="/pubmed/38116684" target="_blank">38116684</a><a href="/pmc/articles/PMC10942178" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/34101496">Randomized Study on Dose Escalation in Definitive Chemoradiation for Patients With Locally Advanced Esophageal Cancer (ARTDECO Study).</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Hulshof MCCM,
Geijsen ED,
Rozema T,
Oppedijk V,
Buijsen J,
Neelis KJ,
Nuyttens JJME,
van der Sangen MJC,
Jeene PM,
Reinders JG,
van Berge Henegouwen MI,
Thano A,
van Hooft JE,
van Laarhoven HWM,
van der Gaast A</span><br />
<span class="medgenPMjournal">J Clin Oncol</span>
2021 Sep 1;39(25):2816-2824.
Epub 2021 Jun 8
doi: 10.1200/JCO.20.03697.
<span class="bold">PMID: </span><a href="/pubmed/34101496" target="_blank">34101496</a></div>
<div class="nl"><a target="_blank" href="/pubmed/21879261">A randomized trial comparing postoperative adjuvant chemotherapy with cisplatin and 5-fluorouracil versus preoperative chemotherapy for localized advanced squamous cell carcinoma of the thoracic esophagus (JCOG9907).</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Ando N,
Kato H,
Igaki H,
Shinoda M,
Ozawa S,
Shimizu H,
Nakamura T,
Yabusaki H,
Aoyama N,
Kurita A,
Ikeda K,
Kanda T,
Tsujinaka T,
Nakamura K,
Fukuda H</span><br />
<span class="medgenPMjournal">Ann Surg Oncol</span>
2012 Jan;19(1):68-74.
Epub 2011 Aug 31
doi: 10.1245/s10434-011-2049-9.
<span class="bold">PMID: </span><a href="/pubmed/21879261" target="_blank">21879261</a></div>
<div class="nl"><a target="_blank" href="/pubmed/10619509">Treatment of esophageal carcinoma.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Lerut T,
Coosemans W,
De Leyn P,
Van Raemdonck D,
Deneffe G,
Decker G</span><br />
<span class="medgenPMjournal">Chest</span>
1999 Dec;116(6 Suppl):463S-465S.
doi: 10.1378/chest.116.suppl_3.463s.
<span class="bold">PMID: </span><a href="/pubmed/10619509" target="_blank">10619509</a></div>
<div class="nl"><a target="_blank" href="/pubmed/10343237">Inoperable esophageal carcinoma.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Caletti G,
Fusaroli P,
Villa-Gomez Roig G,
De Groot KM,
Nageshwar Reddy D</span><br />
<span class="medgenPMjournal">Gastrointest Endosc</span>
1999 Jun;49(6):814-6; discussion 816-7.
doi: 10.1016/s0016-5107(99)70321-4.
<span class="bold">PMID: </span><a href="/pubmed/10343237" target="_blank">10343237</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Esophageal%20carcinoma%22%20AND%20Prognosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (2148)</a></div><h3 class="subhead">Clinical prediction guides</h3>
<div class="nl"><a target="_blank" href="/pubmed/38292873">Survival benefit of combined immunotherapy and chemoradiotherapy in locally advanced unresectable esophageal cancer: an analysis based on the SEER database.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Xie L,
Zhang Z</span><br />
<span class="medgenPMjournal">Front Immunol</span>
2024;15:1334992.
Epub 2024 Jan 16
doi: 10.3389/fimmu.2024.1334992.
<span class="bold">PMID: </span><a href="/pubmed/38292873" target="_blank">38292873</a><a href="/pmc/articles/PMC10825045" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/37915027">Survival outcomes of esophageal cancer patients with recurrence after curative treatments.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Sugawara K,
Oka D,
Hara H,
Yoshii T,
Ushijima H,
Kudo S,
Fukuda T</span><br />
<span class="medgenPMjournal">BMC Cancer</span>
2023 Nov 1;23(1):1051.
doi: 10.1186/s12885-023-11568-w.
<span class="bold">PMID: </span><a href="/pubmed/37915027" target="_blank">37915027</a><a href="/pmc/articles/PMC10619310" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/37569718">Cyclooxygenase and Cancer: Fundamental Molecular Investigations.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Coluccia M</span><br />
<span class="medgenPMjournal">Int J Mol Sci</span>
2023 Aug 2;24(15)
doi: 10.3390/ijms241512342.
<span class="bold">PMID: </span><a href="/pubmed/37569718" target="_blank">37569718</a><a href="/pmc/articles/PMC10418830" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/35042519">A signature of saliva-derived exosomal small RNAs as predicting biomarker for esophageal carcinoma: a multicenter prospective study.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Li K,
Lin Y,
Luo Y,
Xiong X,
Wang L,
Durante K,
Li J,
Zhou F,
Guo Y,
Chen S,
Chen Y,
Zhang D,
Yeung SJ,
Zhang H</span><br />
<span class="medgenPMjournal">Mol Cancer</span>
2022 Jan 18;21(1):21.
doi: 10.1186/s12943-022-01499-8.
<span class="bold">PMID: </span><a href="/pubmed/35042519" target="_blank">35042519</a><a href="/pmc/articles/PMC8764835" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/26185366">Esophageal cancer: Risk factors, screening and endoscopic treatment in Western and Eastern countries.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Domper Arnal MJ,
Ferrández Arenas Á,
Lanas Arbeloa Á</span><br />
<span class="medgenPMjournal">World J Gastroenterol</span>
2015 Jul 14;21(26):7933-43.
doi: 10.3748/wjg.v21.i26.7933.
<span class="bold">PMID: </span><a href="/pubmed/26185366" target="_blank">26185366</a><a href="/pmc/articles/PMC4499337" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Esophageal%20carcinoma%22%20AND%20Clinical%20prediction%20guides%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (1422)</a></div></div>
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_systematic_reviews">Recent systematic reviews</h1><a sid="104" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln">
<div class="nl"><a target="_blank" href="/pubmed/33787334">Diagnostic Performance of MRI for Esophageal Carcinoma: A Systematic Review and Meta-Analysis.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Lee SL,
Yadav P,
Starekova J,
Christensen L,
Chandereng T,
Chappell R,
Reeder SB,
Bassetti MF</span><br />
<span class="medgenPMjournal">Radiology</span>
2021 Jun;299(3):583-594.
Epub 2021 Mar 30
doi: 10.1148/radiol.2021202857.
<span class="bold">PMID: </span><a href="/pubmed/33787334" target="_blank">33787334</a></div>
<div class="nl"><a target="_blank" href="/pubmed/32568633">Treatment of Locally Advanced Esophageal Carcinoma: ASCO Guideline.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Shah MA,
Kennedy EB,
Catenacci DV,
Deighton DC,
Goodman KA,
Malhotra NK,
Willett C,
Stiles B,
Sharma P,
Tang L,
Wijnhoven BPL,
Hofstetter WL</span><br />
<span class="medgenPMjournal">J Clin Oncol</span>
2020 Aug 10;38(23):2677-2694.
Epub 2020 Jun 22
doi: 10.1200/JCO.20.00866.
<span class="bold">PMID: </span><a href="/pubmed/32568633" target="_blank">32568633</a></div>
<div class="nl"><a target="_blank" href="/pubmed/30791842">Systematic review: the etiology of esophageal squamous cell carcinoma in low-income settings.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Chetwood JD,
Garg P,
Finch P,
Gordon M</span><br />
<span class="medgenPMjournal">Expert Rev Gastroenterol Hepatol</span>
2019 Jan;13(1):71-88.
Epub 2018 Nov 14
doi: 10.1080/17474124.2019.1543024.
<span class="bold">PMID: </span><a href="/pubmed/30791842" target="_blank">30791842</a></div>
<div class="nl"><a target="_blank" href="/pubmed/28859394">Esophageal achalasia: a risk factor for carcinoma. A systematic review and meta-analysis.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Tustumi F,
Bernardo WM,
da Rocha JRM,
Szachnowicz S,
Seguro FC,
Bianchi ET,
Sallum RAA,
Cecconello I</span><br />
<span class="medgenPMjournal">Dis Esophagus</span>
2017 Oct 1;30(10):1-8.
doi: 10.1093/dote/dox072.
<span class="bold">PMID: </span><a href="/pubmed/28859394" target="_blank">28859394</a></div>
<div class="nl"><a target="_blank" href="/pubmed/26462879">Teeth loss, teeth brushing and esophageal carcinoma: a systematic review and meta-analysis.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Chen H,
Nie S,
Zhu Y,
Lu M</span><br />
<span class="medgenPMjournal">Sci Rep</span>
2015 Oct 14;5:15203.
doi: 10.1038/srep15203.
<span class="bold">PMID: </span><a href="/pubmed/26462879" target="_blank">26462879</a><a href="/pmc/articles/PMC4604458" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Esophageal%20carcinoma%22%20AND%20systematic%5Bsb%5D%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (71)</a></div></div>
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<div class="portlet_content ln"><ul><li><a href="/gtr/tests?term=C0152018%5bDISCUI%5d&amp;filter=method%3A2%5F7" target="_blank">Sequence analysis of the entire coding region (1)</a></li>
<li><a href="/gtr/tests?term=C0152018%5bDISCUI%5d&amp;filter=method%3A2%5F19" target="_blank">Targeted variant analysis (1)</a></li>
<li class="portletSeeAll portletSeeAllPad"><total><a href="/gtr/tests?term=C0152018%5bDISCUI%5d" target="_blank">See all (2)</a></total></li>
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<div class="portlet_content ln"><ul><li><a href="http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Expert=70482" target="_blank">Orphanet</a></li><li><a href="https://clinicaltrials.gov/search?cond=Carcinoma%20of%20esophagus" target="_blank">ClinicalTrials.gov</a></li></ul></div>
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