668 lines
No EOL
111 KiB
HTML
668 lines
No EOL
111 KiB
HTML
<?xml version="1.0" encoding="utf-8"?>
|
||
<!DOCTYPE html PUBLIC "-//W3C//DTD XHTML 1.0 Transitional//EN" "http://www.w3.org/TR/xhtml1/DTD/xhtml1-transitional.dtd">
|
||
<html xmlns="http://www.w3.org/1999/xhtml" lang="en" xml:lang="en">
|
||
<head xmlns:xi="http://www.w3.org/2001/XInclude"><meta http-equiv="Content-Type" content="text/html; charset=utf-8" />
|
||
<!-- meta -->
|
||
<meta name="keywords" content="C0079744, centroblastic diffuse large b-cell malignant lymphoma, centroblastic diffuse malignant lymphoma, centroblastic malignant lymphoma, diffuse histiocytic lymphoma, diffuse histiocytic lymphomas, diffuse large b cell lymphoma, diffuse large b cell malignant lymphoma, diffuse large b-cell lymphoma, diffuse large b-cell malignant lymphoma, diffuse large cell lymphoma, diffuse large cleaved cell malignant lymphoma, diffuse large noncleaved cell malignant lymphoma, diffuse large-cell lymphoma, diffuse large-cell lymphomas, diffuse malignant lymphoma - histiocytic, diffuse malignant lymphoma - large cell, diffuse non-hodgkin lymphoma, large cell, diffuse non-hodgkin's lymphoma, large cell, diffuse, large b-cell, lymphoma, dlbcl, dlbcl - diffuse large b cell lymphoma, histiocytic diffuse malignant lymphoma, histiocytic lymphoma, histiocytic lymphoma, diffuse, histiocytic lymphomas, histiocytic malignant lymphoma, large b-cell malignant lymphoma, large cell lymphoma, diffuse, large cell malignant lymphoma, large cleaved cell and noncleaved cell malignant lymphoma, large cleaved cell malignant lymphoma, large lymphoid lymphoma, diffuse, large noncleaved cell malignant lymphoma, large-cell lymphoma, diffuse, lymphoma, diffuse histiocytic, lymphoma, diffuse large b cell, non hodgkins, lymphoma, diffuse large cell, lymphoma, diffuse large-cell, lymphoma, histiocytic, lymphoma, histiocytic, diffuse, lymphoma, large b-cell, diffuse, lymphoma, large cell, diffuse, lymphoma, large lymphoid, diffuse, lymphoma, large-cell, diffuse, malignant lymphoma - large cell cleaved and non-cleaved, malignant lymphoma, large b-cell, diffuse, neoplastic process, noncleaved malignant lymphoma, autosomal dominant, autosomal recessive, birth defects, chromosomal disease, chromosome, clinical features, clinical findings, clinical genetics, clinical recommendations, clinvar, congenital chromosomal disease, consumer genetic resources, cytogenetic location, disease characteristics, disease definitions, disease descriptions, disease ontology, disease synonyms, disease vocabulary, dysmorphology, entrez, familial disease, gene, gene-disease relationship, genereviews, genetic disease, genetic disorder, genetic terminology, genetic testing registry, genetics home reference, genomic disease, gtr, hereditary disease, heritable disease, hpo, human phenotype ontology, inherited disease, management guidelines, maternal inheritance, medgen, medical genetics, medical subject headings, mesh, mitochondrial inheritance, mode of inheritance, national center for biotechnology information, national institutes of health, national library of medicine, ncbi, nih, nlm, omim, ordo, orphanet, paternal inheritance, phenome, position statements, professional practice guidelines, rare disease, reference sequence, refseq, snomed ct, syndrome, undiagnosed diseases, x-linked recessive" /><meta name="description" content="Diffuse large B-cell lymphoma is the most common subtype of non-Hodgkin lymphoma (NHL; see this term) in adults characterized by a median age of presentation in the sixth decade of life (but also rarely occurring in adolescents and children) with the initial presentation being single or multiple rapidly growing masses (that may or may not be painful) in nodal or extranodal sites (such as thyroid, skin, breast, gastrointestinal tract, testes, bone, or brain) and that can be accompanied by symptoms of fever, night sweats and weight loss. DLBCL has an aggressive disease course, with the elderly having a poorer prognosis than younger patients, and with relapses being common." /><meta name="robots" content="index,nofollow,noarchive" />
|
||
<meta name="ncbi_app" content="entrez" /><meta name="ncbi_db" content="medgen" /><meta name="ncbi_term" content="c0079744[conceptid]" /><meta name="ncbi_report" content="fullreport" /><meta name="ncbi_format" content="html" /><meta name="ncbi_pagesize" content="20" /><meta name="ncbi_sortorder" content="default" /><meta name="ncbi_pageno" content="1" /><meta name="ncbi_resultcount" content="1" /><meta name="ncbi_op" content="search" /><meta name="ncbi_pdid" content="fullreport" /><meta name="ncbi_sessionid" content="CE8B5AF87C7FFCB1_0191SID" /><meta name="ncbi_filter" content="clinical" /><meta name="ncbi_stat" content="false" /><meta name="ncbi_hitstat" content="false" />
|
||
|
||
|
||
<!-- title -->
|
||
<title>Malignant lymphoma, large B-cell, diffuse (Concept Id: C0079744)
|
||
- MedGen - NCBI</title>
|
||
|
||
<!-- Common JS and CSS -->
|
||
|
||
<script type="text/javascript">
|
||
var ncbi_startTime = new Date();
|
||
</script>
|
||
<script type="text/javascript" src="https://static.pubmed.gov/core/jig/1.15.10/js/jig.min.js"></script>
|
||
|
||
<link xmlns="http://www.w3.org/1999/xhtml" type="text/css" rel="stylesheet" href="//static.pubmed.gov/portal/portal3rc.fcgi/4218191/css/4207974/4206132.css" xml:base="http://127.0.0.1/sites/static/header_footer/" />
|
||
<link rel="shortcut icon" href="//www.ncbi.nlm.nih.gov/favicon.ico" /><meta name="ncbi_phid" content="CE8DD8927D18939100000000009F007A.m_32" /><script type="text/javascript"><!--
|
||
var ScriptPath = '/portal/';
|
||
var objHierarchy = {"name":"EntrezSystem2","type":"Layout","realname":"EntrezSystem2",
|
||
"children":[{"name":"EntrezSystem2.PEntrez","type":"Cluster","realname":"EntrezSystem2.PEntrez",
|
||
"children":[{"name":"EntrezSystem2.PEntrez.DbConnector","type":"Portlet","realname":"EntrezSystem2.PEntrez.PEntrez.DbConnector","shortname":"DbConnector"},
|
||
{"name":"EntrezSystem2.PEntrez.ParamContainer","type":"Portlet","realname":"EntrezSystem2.PEntrez.PEntrez.ParamContainer","shortname":"ParamContainer"},
|
||
{"name":"EntrezSystem2.PEntrez.MyNcbi","type":"Portlet","realname":"EntrezSystem2.PEntrez.PEntrez.MyNcbi","shortname":"MyNcbi"},
|
||
{"name":"EntrezSystem2.PEntrez.UserPreferenceUrlParamContainer","type":"Portlet","realname":"EntrezSystem2.PEntrez.PEntrez.UserPreferenceUrlParamContainer","shortname":"UserPreferenceUrlParamContainer"},
|
||
{"name":"EntrezSystem2.PEntrez.GridProperty","type":"Portlet","realname":"EntrezSystem2.PEntrez.PEntrez.GridProperty","shortname":"GridProperty"},
|
||
{"name":"EntrezSystem2.PEntrez.MedGen","type":"Cluster","realname":"EntrezSystem2.PEntrez.MedGen",
|
||
"children":[{"name":"EntrezSystem2.PEntrez.MedGen.NoPortlet","type":"Portlet","realname":"EntrezSystem2.PEntrez.MedGen.Entrez_Database.NoPortlet","shortname":"NoPortlet"},
|
||
{"name":"EntrezSystem2.PEntrez.MedGen.MedGen_PageController","type":"Portlet","realname":"EntrezSystem2.PEntrez.MedGen.MedGen_PageController","shortname":"MedGen_PageController"},
|
||
{"name":"EntrezSystem2.PEntrez.MedGen.MedGen_SearchBar","type":"Portlet","realname":"EntrezSystem2.PEntrez.MedGen.MedGen_SearchBar","shortname":"MedGen_SearchBar"},
|
||
{"name":"EntrezSystem2.PEntrez.MedGen.MedGen_BotRequest","type":"Portlet","realname":"EntrezSystem2.PEntrez.MedGen.MedGen_BotRequest","shortname":"MedGen_BotRequest"},
|
||
{"name":"EntrezSystem2.PEntrez.MedGen.MedGen_LimitsTab","type":"Portlet","realname":"EntrezSystem2.PEntrez.MedGen.MedGen_LimitsTab","shortname":"MedGen_LimitsTab"},
|
||
{"name":"EntrezSystem2.PEntrez.MedGen.Entrez_Facets","type":"Portlet","realname":"EntrezSystem2.PEntrez.MedGen.Entrez_Database.Entrez_Facets","shortname":"Entrez_Facets"},
|
||
{"name":"EntrezSystem2.PEntrez.MedGen.Entrez_Clipboard","type":"Portlet","realname":"EntrezSystem2.PEntrez.MedGen.Entrez_Database.Entrez_Clipboard","shortname":"Entrez_Clipboard"},
|
||
{"name":"EntrezSystem2.PEntrez.MedGen.MedGen_StaticParts","type":"Portlet","realname":"EntrezSystem2.PEntrez.MedGen.MedGen_StaticParts","shortname":"MedGen_StaticParts"},
|
||
{"name":"EntrezSystem2.PEntrez.MedGen.Entrez_Messages","type":"Portlet","realname":"EntrezSystem2.PEntrez.MedGen.Entrez_Database.Entrez_Messages","shortname":"Entrez_Messages"},
|
||
{"name":"EntrezSystem2.PEntrez.MedGen.NcbiJSCheck","type":"Portlet","realname":"EntrezSystem2.PEntrez.MedGen.Entrez_Database.NcbiJSCheck","shortname":"NcbiJSCheck"},
|
||
{"name":"EntrezSystem2.PEntrez.MedGen.NCBIFooter_dynamic","type":"Cluster","realname":"EntrezSystem2.PEntrez.MedGen.Entrez_Database.NCBIFooter_dynamic",
|
||
"children":[{"name":"EntrezSystem2.PEntrez.MedGen.NCBIFooter_dynamic.Footer_ExtraData","type":"Portlet","realname":"EntrezSystem2.PEntrez.MedGen.Entrez_Database.NCBIFooter_dynamic.Footer_ExtraData","shortname":"Footer_ExtraData"},
|
||
{"name":"EntrezSystem2.PEntrez.MedGen.NCBIFooter_dynamic.NCBIFooter_dynamic","type":"Cluster","realname":"EntrezSystem2.PEntrez.MedGen.Entrez_Database.NCBIFooter_dynamic.NCBIFooter_dynamic",
|
||
"children":[{"name":"EntrezSystem2.PEntrez.MedGen.NCBIFooter_dynamic.NCBIFooter_dynamic.NCBIBreadcrumbs","type":"Portlet","realname":"EntrezSystem2.PEntrez.MedGen.Entrez_Database.NCBIFooter_dynamic.NCBIFooter_dynamic.NCBIBreadcrumbs","shortname":"NCBIBreadcrumbs"},
|
||
{"name":"EntrezSystem2.PEntrez.MedGen.NCBIFooter_dynamic.NCBIFooter_dynamic.NCBIHelpDesk","type":"Portlet","realname":"EntrezSystem2.PEntrez.MedGen.Entrez_Database.NCBIFooter_dynamic.NCBIFooter_dynamic.NCBIHelpDesk","shortname":"NCBIHelpDesk"},
|
||
{"name":"EntrezSystem2.PEntrez.MedGen.NCBIFooter_dynamic.NCBIFooter_dynamic.NCBIApplog_NoScript_Ping","type":"Portlet","realname":"EntrezSystem2.PEntrez.MedGen.Entrez_Database.NCBIFooter_dynamic.NCBIFooter_dynamic.NCBIApplog_NoScript_Ping","shortname":"NCBIApplog_NoScript_Ping"}]}]},
|
||
{"name":"EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel","type":"Cluster","realname":"EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel",
|
||
"children":[{"name":"EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.blankToolPanel","type":"Portlet","realname":"EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.Entrez_ResultsPanel.blankToolPanel","shortname":"blankToolPanel"},
|
||
{"name":"EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_ResultsController","type":"Portlet","realname":"EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_ResultsController","shortname":"MedGen_ResultsController"},
|
||
{"name":"EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_FiltersPortlet","type":"Portlet","realname":"EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_FiltersPortlet","shortname":"MedGen_FiltersPortlet"},
|
||
{"name":"EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.Entrez_Pager","type":"Portlet","realname":"EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.Entrez_ResultsPanel.Entrez_Pager","shortname":"Entrez_Pager"},
|
||
{"name":"EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_DisplayBar","type":"Portlet","realname":"EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_DisplayBar","shortname":"MedGen_DisplayBar"},
|
||
{"name":"EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.HelpFormAttributes","type":"Portlet","realname":"EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.Entrez_ResultsPanel.HelpFormAttributes","shortname":"HelpFormAttributes"},
|
||
{"name":"EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.Entrez_Collections","type":"Portlet","realname":"EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.Entrez_ResultsPanel.Entrez_Collections","shortname":"Entrez_Collections"},
|
||
{"name":"EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.SpellCheck","type":"Portlet","realname":"EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.Entrez_ResultsPanel.SpellCheck","shortname":"SpellCheck"},
|
||
{"name":"EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.SearchEngineReferralCheck","type":"Portlet","realname":"EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.Entrez_ResultsPanel.SearchEngineReferralCheck","shortname":"SearchEngineReferralCheck"},
|
||
{"name":"EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.WrongDbSensor","type":"Portlet","realname":"EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.Entrez_ResultsPanel.WrongDbSensor","shortname":"WrongDbSensor"},
|
||
{"name":"EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.KnowledgePanel","type":"Portlet","realname":"EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.Entrez_ResultsPanel.KnowledgePanel","shortname":"KnowledgePanel"},
|
||
{"name":"EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.HistoryDisplay","type":"Portlet","realname":"EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.Entrez_ResultsPanel.HistoryDisplay","shortname":"HistoryDisplay"},
|
||
{"name":"EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.Discovery_SearchDetails","type":"Portlet","realname":"EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.Entrez_ResultsPanel.Discovery_SearchDetails","shortname":"Discovery_SearchDetails"},
|
||
{"name":"EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.mg_GeneSensor","type":"Portlet","realname":"EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.mg_GeneSensor","shortname":"mg_GeneSensor"},
|
||
{"name":"EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_ClinFeatureSearch","type":"Portlet","realname":"EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_ClinFeatureSearch","shortname":"MedGen_ClinFeatureSearch"},
|
||
{"name":"EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_RVFull","type":"Portlet","realname":"EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_RVFull","shortname":"MedGen_RVFull"},
|
||
{"name":"EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_SingleItemSuplCluster","type":"Cluster","realname":"EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_SingleItemSuplCluster",
|
||
"children":[{"name":"EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_SingleItemSuplCluster.MedGenDiscoveryDbLinks","type":"Portlet","realname":"EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_SingleItemSuplCluster.MedGenDiscoveryDbLinks","shortname":"MedGenDiscoveryDbLinks"},
|
||
{"name":"EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_SingleItemSuplCluster.MedGen_SingleItemSupl","type":"Portlet","realname":"EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_SingleItemSuplCluster.MedGen_SingleItemSupl","shortname":"MedGen_SingleItemSupl"},
|
||
{"name":"EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_SingleItemSuplCluster.MedGenReviews","type":"Portlet","realname":"EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_SingleItemSuplCluster.MedGenReviews","shortname":"MedGenReviews"}]}]}]}]}]};
|
||
--></script>
|
||
<meta name='referrer' content='origin-when-cross-origin'/><link type="text/css" rel="stylesheet" href="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/css/3808861/3917732/3974050/3751656/3395415/4221762/14534/4062871/4186458/4075711/12930/4033350/4128070/3861632/4013176/4212357/4064428/4186491/9685/2279/3395586.css" /><link type="text/css" rel="stylesheet" href="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/css/3501913/1303451.css" media="print" /><script type="text/javascript">
|
||
|
||
var ObjectLinks=[{i:0, ename: "p$ExL", esid:"*", sname: "p$ExL", ssid:"*", dname:"p$el", dsid:"0",m:"CopyValue",p:[],f: function(src, dst) {fn_CopyValue(src, dst);}}]
|
||
|
||
|
||
var ActiveNames = {"p$ExL":1, "EntrezSystem2.PEntrez.DbConnector.Cmd":0, "EntrezSystem2.PEntrez.DbConnector.Db":0, "EntrezSystem2.PEntrez.DbConnector.IdsFromResult":0, "EntrezSystem2.PEntrez.DbConnector.LastDb":0, "EntrezSystem2.PEntrez.DbConnector.LastIdsFromResult":0, "EntrezSystem2.PEntrez.DbConnector.LastQueryKey":0, "EntrezSystem2.PEntrez.DbConnector.LastTabCmd":0, "EntrezSystem2.PEntrez.DbConnector.LinkName":0, "EntrezSystem2.PEntrez.DbConnector.LinkReadableName":0, "EntrezSystem2.PEntrez.DbConnector.LinkSrcDb":0, "EntrezSystem2.PEntrez.DbConnector.QueryKey":0, "EntrezSystem2.PEntrez.DbConnector.TabCmd":0, "EntrezSystem2.PEntrez.DbConnector.Term":0, "EntrezSystem2.PEntrez.MedGen.MedGen_PageController.PreviousPageName":0, "EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.HistoryDisplay.ClearHistory":0, "EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.HistoryDisplay.Cmd":0, "EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.HistoryDisplay.HistoryOn":0, "EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.HistoryDisplay.HistoryToggle":0, "EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.HistoryDisplay.Shutter":0, "EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_DisplayBar.Display":0, "EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_DisplayBar.FFormat":0, "EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_DisplayBar.FileFormat":0, "EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_DisplayBar.Format":0, "EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_DisplayBar.LastFormat":0, "EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_DisplayBar.LastPageSize":0, "EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_DisplayBar.LastPresentation":0, "EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_DisplayBar.PageSize":0, "EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_DisplayBar.Presentation":0, "EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_DisplayBar.PrevPageSize":0, "EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_DisplayBar.PrevPresentation":0, "EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_DisplayBar.PrevSort":0, "EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_DisplayBar.SendTo":0, "EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_DisplayBar.SendToSubmit":0, "EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_DisplayBar.SetDisplay":0, "EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_DisplayBar.sPresentation":0, "EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_ResultsController.ResultCount":0, "EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_ResultsController.RunLastQuery":0, "EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_SingleItemSuplCluster.MedGenDiscoveryDbLinks.Shutter":0, "EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_SingleItemSuplCluster.MedGenReviews.Shutter":0};
|
||
</script></head>
|
||
<body>
|
||
<div class="grid">
|
||
<div class="col twelve_col nomargin shadow">
|
||
<form enctype="application/x-www-form-urlencoded" name="EntrezForm" method="post" onsubmit="return false;" action="/medgen" id="EntrezForm">
|
||
<div xmlns:xi="http://www.w3.org/2001/XInclude">
|
||
<!-- no javascript message -->
|
||
<noscript>
|
||
<p class="nojs">
|
||
<strong>Warning:</strong>
|
||
The NCBI web site requires JavaScript to function.
|
||
<a href="/guide/browsers/#enablejs" title="Learn how to enable JavaScript" target="_blank">more...</a>
|
||
</p>
|
||
</noscript>
|
||
|
||
<div xmlns="http://www.w3.org/1999/xhtml" id="universal_header" xml:base="http://127.0.0.1/sites/static/header_footer/">
|
||
<section class="usa-banner">
|
||
<div class="usa-accordion">
|
||
<header class="usa-banner-header">
|
||
<div class="usa-grid usa-banner-inner">
|
||
<img src="https://www.ncbi.nlm.nih.gov/coreutils/uswds/img/favicons/favicon-57.png" alt="U.S. flag" />
|
||
<p>An official website of the United States government</p>
|
||
<button class="non-usa-accordion-button usa-banner-button" aria-expanded="false" aria-controls="gov-banner-top" type="button">
|
||
<span class="usa-banner-button-text">Here's how you know</span>
|
||
</button>
|
||
</div>
|
||
</header>
|
||
<div class="usa-banner-content usa-grid usa-accordion-content" id="gov-banner-top" aria-hidden="true">
|
||
<div class="usa-banner-guidance-gov usa-width-one-half">
|
||
<img class="usa-banner-icon usa-media_block-img" src="https://www.ncbi.nlm.nih.gov/coreutils/uswds/img/icon-dot-gov.svg" alt="Dot gov" />
|
||
<div class="usa-media_block-body">
|
||
<p>
|
||
<strong>The .gov means it's official.</strong>
|
||
<br />
|
||
Federal government websites often end in .gov or .mil. Before
|
||
sharing sensitive information, make sure you're on a federal
|
||
government site.
|
||
</p>
|
||
</div>
|
||
</div>
|
||
<div class="usa-banner-guidance-ssl usa-width-one-half">
|
||
<img class="usa-banner-icon usa-media_block-img" src="https://www.ncbi.nlm.nih.gov/coreutils/uswds/img/icon-https.svg" alt="Https" />
|
||
<div class="usa-media_block-body">
|
||
<p>
|
||
<strong>The site is secure.</strong>
|
||
<br />
|
||
The <strong>https://</strong> ensures that you are connecting to the
|
||
official website and that any information you provide is encrypted
|
||
and transmitted securely.
|
||
</p>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
</section>
|
||
<div class="usa-overlay"></div>
|
||
<header class="ncbi-header" role="banner" data-section="Header">
|
||
|
||
<div class="usa-grid">
|
||
<div class="usa-width-one-whole">
|
||
|
||
<div class="ncbi-header__logo">
|
||
<a href="/" class="logo" aria-label="NCBI Logo" data-ga-action="click_image" data-ga-label="NIH NLM Logo">
|
||
<img src="https://www.ncbi.nlm.nih.gov/coreutils/nwds/img/logos/AgencyLogo.svg" alt="NIH NLM Logo" />
|
||
</a>
|
||
</div>
|
||
|
||
<div class="ncbi-header__account">
|
||
<a id="account_login" href="https://account.ncbi.nlm.nih.gov" class="usa-button header-button" style="display:none" data-ga-action="open_menu" data-ga-label="account_menu">Log in</a>
|
||
<button id="account_info" class="header-button" style="display:none" aria-controls="account_popup" type="button">
|
||
<span class="fa fa-user" aria-hidden="true">
|
||
<svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 24 24" width="20px" height="20px">
|
||
<g style="fill: #fff">
|
||
<ellipse cx="12" cy="8" rx="5" ry="6"></ellipse>
|
||
<path d="M21.8,19.1c-0.9-1.8-2.6-3.3-4.8-4.2c-0.6-0.2-1.3-0.2-1.8,0.1c-1,0.6-2,0.9-3.2,0.9s-2.2-0.3-3.2-0.9 C8.3,14.8,7.6,14.7,7,15c-2.2,0.9-3.9,2.4-4.8,4.2C1.5,20.5,2.6,22,4.1,22h15.8C21.4,22,22.5,20.5,21.8,19.1z"></path>
|
||
</g>
|
||
</svg>
|
||
</span>
|
||
<span class="username desktop-only" aria-hidden="true" id="uname_short"></span>
|
||
<span class="sr-only">Show account info</span>
|
||
</button>
|
||
</div>
|
||
|
||
<div class="ncbi-popup-anchor">
|
||
<div class="ncbi-popup account-popup" id="account_popup" aria-hidden="true">
|
||
<div class="ncbi-popup-head">
|
||
<button class="ncbi-close-button" data-ga-action="close_menu" data-ga-label="account_menu" type="button">
|
||
<span class="fa fa-times">
|
||
<svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 48 48" width="24px" height="24px">
|
||
<path d="M38 12.83l-2.83-2.83-11.17 11.17-11.17-11.17-2.83 2.83 11.17 11.17-11.17 11.17 2.83 2.83 11.17-11.17 11.17 11.17 2.83-2.83-11.17-11.17z"></path>
|
||
</svg>
|
||
</span>
|
||
<span class="usa-sr-only">Close</span></button>
|
||
<h4>Account</h4>
|
||
</div>
|
||
<div class="account-user-info">
|
||
Logged in as:<br />
|
||
<b><span class="username" id="uname_long">username</span></b>
|
||
</div>
|
||
<div class="account-links">
|
||
<ul class="usa-unstyled-list">
|
||
<li><a id="account_myncbi" href="/myncbi/" class="set-base-url" data-ga-action="click_menu_item" data-ga-label="account_myncbi">Dashboard</a></li>
|
||
<li><a id="account_pubs" href="/myncbi/collections/bibliography/" class="set-base-url" data-ga-action="click_menu_item" data-ga-label="account_pubs">Publications</a></li>
|
||
<li><a id="account_settings" href="/account/settings/" class="set-base-url" data-ga-action="click_menu_item" data-ga-label="account_settings">Account settings</a></li>
|
||
<li><a id="account_logout" href="/account/signout/" class="set-base-url" data-ga-action="click_menu_item" data-ga-label="account_logout">Log out</a></li>
|
||
</ul>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
|
||
</div>
|
||
</div>
|
||
</header>
|
||
<div role="navigation" aria-label="access keys">
|
||
<a id="nws_header_accesskey_0" href="https://www.ncbi.nlm.nih.gov/guide/browsers/#ncbi_accesskeys" class="usa-sr-only" accesskey="0" tabindex="-1">Access keys</a>
|
||
<a id="nws_header_accesskey_1" href="https://www.ncbi.nlm.nih.gov" class="usa-sr-only" accesskey="1" tabindex="-1">NCBI Homepage</a>
|
||
<a id="nws_header_accesskey_2" href="/myncbi/" class="set-base-url usa-sr-only" accesskey="2" tabindex="-1">MyNCBI Homepage</a>
|
||
<a id="nws_header_accesskey_3" href="#maincontent" class="usa-sr-only" accesskey="3" tabindex="-1">Main Content</a>
|
||
<a id="nws_header_accesskey_4" href="#" class="usa-sr-only" accesskey="4" tabindex="-1">Main Navigation</a>
|
||
</div>
|
||
<section data-section="Alerts">
|
||
<div class="ncbi-alerts-placeholder"></div>
|
||
</section>
|
||
</div>
|
||
|
||
<div class="header">
|
||
<!-- logo -->
|
||
<div class="res_logo" id="gene-top">
|
||
<h1 class="res_name"><a href="/medgen">MedGen</a></h1>
|
||
<h2 class="res_tagline">National Center for Biotechnology Information</h2>
|
||
</div>
|
||
<!-- SearchBar -->
|
||
<div class="search"><div class="search_form"><label for="database" class="offscreen_noflow">Search database</label><select id="database"><optgroup label="Recent"><option value="medgen" selected="selected" data-ac_dict="medgen_disease_name">MedGen</option><option value="clinvar">ClinVar</option><option value="pubmed" data-ac_dict="pm_related_queries_2">PubMed</option><option value="books" class="last">Books</option></optgroup><optgroup label="All"><option value="gquery">All Databases</option><option value="assembly">Assembly</option><option value="biocollections">Biocollections</option><option value="bioproject">BioProject</option><option value="biosample">BioSample</option><option value="books">Books</option><option value="clinvar">ClinVar</option><option value="cdd">Conserved Domains</option><option value="gap">dbGaP</option><option value="dbvar">dbVar</option><option value="gene">Gene</option><option value="genome">Genome</option><option value="gds">GEO DataSets</option><option value="geoprofiles">GEO Profiles</option><option value="gtr">GTR</option><option value="ipg">Identical Protein Groups</option><option value="medgen" data-ac_dict="medgen_disease_name">MedGen</option><option value="mesh" data-ac_dict="mesh_suggestions">MeSH</option><option value="nlmcatalog">NLM Catalog</option><option value="nuccore">Nucleotide</option><option value="omim">OMIM</option><option value="pmc">PMC</option><option value="protein">Protein</option><option value="proteinclusters">Protein Clusters</option><option value="protfam">Protein Family Models</option><option value="pcassay">PubChem BioAssay</option><option value="pccompound">PubChem Compound</option><option value="pcsubstance">PubChem Substance</option><option value="pubmed" data-ac_dict="pm_related_queries_2">PubMed</option><option value="snp">SNP</option><option value="sra">SRA</option><option value="structure">Structure</option><option value="taxonomy">Taxonomy</option><option value="toolkit">ToolKit</option><option value="toolkitall">ToolKitAll</option><option value="toolkitbookgh">ToolKitBookgh</option></optgroup></select><div class="nowrap"><label for="term" class="offscreen_noflow" accesskey="/">Search term</label><div class="nowrap"><input type="text" name="term" id="term" title="Search MedGen. Use up and down arrows to choose an item from the autocomplete." value="" class="jig-ncbiclearbutton jig-ncbiautocomplete" data-jigconfig="dictionary:'medgen_disease_name',disableUrl:'NcbiSearchBarAutoComplCtrl'" autocomplete="off" data-sbconfig="ds:'no',pjs:'yes',afs:'yes'" /></div><button id="search" type="submit" class="button_search nowrap" cmd="go">Search</button></div></div><ul class="searchlinks inline_list"><set></set><li><a name="SaveSearch" title="Click to create an email alert for this search" href="/sites/myncbi/searches/save?db=medgen&qk=22921" id="SaveSearch">Create alert</a></li><li><a sid="1" href="/medgen/limits">Limits</a></li><li><a href="/medgen/advanced">Advanced</a></li><li class="help"><a id="help" class="jig-ncbihelpwindow" target="ncbihelp" name="help" href="/medgen/docs/help">Help</a></li></ul></div>
|
||
</div>
|
||
<input name="EntrezSystem2.PEntrez.MedGen.MedGen_PageController.PreviousPageName" sid="1" type="hidden" value="results" />
|
||
<div id="maincontent" class="col nine_col">
|
||
<div class="content">
|
||
<div>
|
||
|
||
|
||
</div>
|
||
<div class="results_settings one_setting"><ul class="inline_list left display_settings"><li><a name="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_DisplayBar.Display" sid="0" href="#" class="jig-ncbipopper" data-jigconfig="triggerPosition : 'bottom center',destPosition : 'top center',destSelector : '#display_settings_menu_report', hasArrow : false,openEvent : 'click',closeEvent : 'click',isTriggerElementCloseClick: false,addCloseButton : false, groupName: 'entrez_pg'" id="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_DisplayBar.Display">Full Report<span href="#" class="tgt_dark"></span></a></li></ul><div id="display_settings_menu_report" class="disp_settings tabPopper"><fieldset class="format"><legend>Format</legend><ul class="column_list"><li><input type="radio" name="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_DisplayBar.sPresentation" sid="1" value="FullReport" format="" id="FullReport" checked="true" /><label for="FullReport">Full Report</label></li><li><input type="radio" name="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_DisplayBar.sPresentation" sid="2" value="FullReport" format="text" id="FullReporttext" /><label for="FullReporttext">Summary (Text)</label></li><li><input type="radio" name="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_DisplayBar.sPresentation" sid="3" value="XML" format="text" id="XMLtext" /><label for="XMLtext">Summary (XML)</label></li></ul></fieldset></div><button name="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_DisplayBar.SetDisplay" sid="1" class="button_apply ncbipopper-close-button" style="display:none">Apply</button><h4 class="content_header send_to align_right jig-ncbipopper" id="sendto" data-jigconfig="triggerPosition:'bottom center', destPosition : 'top center',destSelector : '#send_to_menu', hasArrow : false, openEvent : 'click',closeEvent : 'click', isTriggerElementCloseClick: false, addCloseButton:true, groupName: 'entrez_pg', adjustFit:'none'"><a href="#" sourceContent="send_to_menu" class="tgt_dark">Send to:</a><script type="text/javascript">
|
||
jQuery(document).ready( function () {
|
||
jQuery("#send_to_menu input[type='radio']").click( function () {
|
||
var selectedValue = jQuery(this).val().toLowerCase();
|
||
var selectedDiv = jQuery("#send_to_menu div." + selectedValue);
|
||
|
||
if(selectedDiv.is(":hidden")){
|
||
jQuery("#send_to_menu div.submenu:visible").slideUp();
|
||
selectedDiv.slideDown();
|
||
}
|
||
});
|
||
|
||
});
|
||
|
||
jQuery("#sendto").bind("ncbipopperclose", function(){
|
||
jQuery("#send_to_menu div.submenu:visible").css("display","none");
|
||
jQuery("#send_to_menu input[type='radio']:checked").attr("checked",false);
|
||
});
|
||
|
||
</script></h4><div id="send_to_menu" class="tabPopper send_to"><fieldset><legend>Choose Destination</legend><ul class="column_list"><li><input type="radio" name="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_DisplayBar.SendTo" sid="1" value="File" id="dest_File" /><label for="dest_File">File</label></li><li><input type="radio" name="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_DisplayBar.SendTo" sid="2" value="AddToClipboard" id="dest_AddToClipboard" /><label for="dest_AddToClipboard">Clipboard</label></li><li><input type="radio" name="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_DisplayBar.SendTo" sid="3" value="AddToCollections" id="dest_AddToCollections" /><label for="dest_AddToCollections">Collections</label></li></ul></fieldset><div class="submenu file" id="submenu_File" style="display: none;"><p id="submenu_File_hint" class="hidden"></p><ul><li><label for="file_format">Format</label><select id="file_format" name="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_DisplayBar.FFormat" sid="1"><option value="FullReport" format="text" selected="selected">Summary (Text)</option><option value="XML" format="text">Summary (XML)</option></select></li></ul><button name="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_DisplayBar.SendToSubmit" sid="1" class="button_apply file ncbipopper-close-button" type="submit" cmd="File">Create File</button></div><div class="submenu addtoclipboard" id="submenu_AddToClipboard" style="display: none;"><p id="submenu_AddToClipboard_hint" class="hidden"></p><button name="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_DisplayBar.SendToSubmit" sid="2" class="button_apply clipboard ncbipopper-close-button" type="submit" cmd="AddToClipboard">Add to Clipboard</button></div><div class="submenu addtocollections" id="submenu_AddToCollections" style="display: none;"><p id="submenu_AddToCollections_hint" class="hidden"></p><button name="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_DisplayBar.SendToSubmit" sid="3" class="button_apply collections ncbipopper-close-button" type="submit" cmd="AddToCollections">Add to Collections</button></div></div><div><input name="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_DisplayBar.FileFormat" sid="1" type="hidden" value="FullReport" /><input name="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_DisplayBar.LastPresentation" sid="1" type="hidden" value="FullReport" /><input name="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_DisplayBar.Presentation" sid="1" type="hidden" value="FullReport" /><input name="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_DisplayBar.PageSize" sid="1" type="hidden" value="20" /><input name="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_DisplayBar.LastPageSize" sid="1" type="hidden" value="20" /><input name="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_DisplayBar.Format" sid="1" type="hidden" value="" /><input name="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_DisplayBar.LastFormat" sid="1" type="hidden" value="" /><input name="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_DisplayBar.PrevPageSize" sid="1" type="hidden" value="20" /><input name="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_DisplayBar.PrevPresentation" sid="1" type="hidden" value="FullReport" /><input name="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_DisplayBar.PrevSort" sid="1" type="hidden" value="" /><input type="hidden" id="coll_startindex" name="CollectionStartIndex" value="1" /></div></div>
|
||
<div class="">
|
||
<div><span id="result_sel" class="nowrap"></span><input name="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_ResultsController.ResultCount" sid="1" type="hidden" id="resultcount" value="1" /><input name="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_ResultsController.RunLastQuery" sid="1" type="hidden" /></div>
|
||
|
||
</div>
|
||
<div id="messagearea" class="empty">
|
||
|
||
|
||
|
||
</div>
|
||
<div><div class="rprt full-rprt"><div class="portlet" style="border-top-style: none; margin-top: 0px; padding-top: 0px; margin-bottom: 0px; padding-left: 0.2em;">
|
||
<!--
|
||
UID=86954
|
||
ConceptID=C0079744
|
||
-->
|
||
<!--imgCountBooks = 0--><h1 class="medgenTitle"><div class="MedGenTitleText">Malignant lymphoma, large B-cell, diffuse</div></h1><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>86954</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information."><span class="highlight" style="background-color:">C0079744</span></a></dd><dt><span class="dotprefix"> •</span></dt><dd>Neoplastic Process</dd></dl></div></div><table class="medgenTable"><tbody><tr><td>Synonym:</td>
|
||
<td>Diffuse large B cell lymphoma</td></tr>
|
||
<tr><td><span class="bold">SNOMED CT: </span></td>
|
||
<td>Diffuse malignant lymphoma - histiocytic (109969005); Diffuse malignant lymphoma - large cell (109969005); Malignant lymphoma - large cell cleaved and non-cleaved (109969005); Diffuse non-Hodgkin's lymphoma, large cell (109969005); Diffuse non-Hodgkin lymphoma, large cell (109969005); Lymphoma, diffuse large B cell, non Hodgkins (109969005); DLBCL - diffuse large B cell lymphoma (109969005); Diffuse large B cell lymphoma (1172695008); Diffuse large B cell malignant lymphoma (1172695008); Large B-cell malignant lymphoma (1172695008); Large cell malignant lymphoma (1172695008); Centroblastic diffuse large B-cell malignant lymphoma (1172695008); Centroblastic diffuse malignant lymphoma (1172695008); Histiocytic malignant lymphoma (1172695008); Centroblastic malignant lymphoma (1172695008); Histiocytic diffuse malignant lymphoma (1172695008); Diffuse large cleaved cell malignant lymphoma (1172695008); Large noncleaved cell malignant lymphoma (1172695008); Noncleaved malignant lymphoma (1172695008); Diffuse large noncleaved cell malignant lymphoma (1172695008); Large cleaved cell and noncleaved cell malignant lymphoma (1172695008); Large cleaved cell malignant lymphoma (1172695008); Diffuse large B-cell lymphoma (109969005); Diffuse large B-cell malignant lymphoma (109969005)</td></tr>
|
||
<tr><td>Modes of inheritance:</td>
|
||
<td>
|
||
<div class="divPopper rprt" id="moi_109109"><div><strong>Non-Mendelian inheritance</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>109109</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0600599</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Genetic Function</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Source: Orphanet</div>
|
||
<div class="spaceAbove">A mode of inheritance that depends on genetic determinants in more than one gene.</div></div>
|
||
<div class="divPopper rprt" id="moi_988794"><div><strong>Not genetically inherited</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>988794</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier assigned by MedGen (starting with CN) for terms that cannot be identified in NLM's Unified Medical Language system (UMLS) Click for more information.">CN307044</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Finding</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Source: Orphanet</div>
|
||
<div class="spaceAbove">clinical entity without genetic inheritance.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/988794">This record</a></div></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#moi_109109" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Non-Mendelian inheritance</a><span> (Orphanet)</span></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#moi_988794" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Not genetically inherited</a><span> (Orphanet)</span></div></td></tr>
|
||
<tr><td colspan="2" class="small"> </td></tr><tr><td>Monarch Initiative:</td>
|
||
<td><a href="https://monarchinitiative.org/disease/MONDO:0018905" target="_blank">MONDO:0018905</a></td></tr>
|
||
<tr><td>Orphanet:</td>
|
||
<td><a target="_blank" title="Orphanet: The portal for rare diseases and orphan drugs" href="http://www.orpha.net/consor/cgi-bin/OC_Exp.php?lng=EN&Expert=544">ORPHA544</a></td></tr></tbody></table></div><div class="rprt-body jig-ncbiinpagenav" data-jigconfig="smoothScroll: false, gotoTopLink: true, gotoTopLinkText: '', gotoTopLinkAttrs: {'title': 'Go to the top of the page'},allHeadingLevels: ['h1'], topOfPageTOC: true, tocId: 'my-toc'"><div id="rprt-tabs-1" class="rprt-tab"><div id="tb-termsProp-1"><div class="leftCol mgCol"><div>
|
||
<div class="portlet mgSection" id="ID_100">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Definition">Definition</h1><a sid="100" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln">Diffuse large B-cell lymphoma is the most common subtype of non-Hodgkin lymphoma (NHL; see this term) in adults characterized by a median age of presentation in the sixth decade of life (but also rarely occurring in adolescents and children) with the initial presentation being single or multiple rapidly growing masses (that may or may not be painful) in nodal or extranodal sites (such as thyroid, skin, breast, gastrointestinal tract, testes, bone, or brain) and that can be accompanied by symptoms of fever, night sweats and weight loss. DLBCL has an aggressive disease course, with the elderly having a poorer prognosis than younger patients, and with relapses being common. [from <a title="Orphanet Rare Disease Ontology (ORDO)" href="http://www.orphadata.org/cgi-bin/inc/ordo_orphanet.inc.php" class="defSource" target="_blank">ORDO</a>]</div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_118">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Term_Hierarchy">Term Hierarchy</h1><a sid="118" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln HierarchyGTR"><div class="jig-ncbitabs"><ul><li><a href="#tabGTR">GTR</a></li><li><a href="#tabMGEN">MeSH</a></li><li><a href="#tabORDO">Orphanet</a></li></ul><div id="tabGTR"><div class="search_result"><div class="rprts"><div class="chiclet_legend"><span class="chiclet_list" style="position:static;"><span title="Clinical test" class="chiclet Ccolor round">C</span><span>Clinical test, </span><span title="Research test" class="chiclet Rcolor round">R</span><span>Research test, </span><span title="OMIM" class="chiclet Ocolor ">O</span><span>OMIM, </span><span title="GeneReview" class="chiclet Gcolor">G</span><span><em>GeneReviews</em>, </span><span title="ClinVar" class="chiclet Vcolor">V</span><span>ClinVar </span></span></div><div id="hierarchy" class="margin_t1"><div class="ds_tree"><ul><li class="matched_ds"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C0079744[DISCUI]&test_type=Clinical" ref="ncbi_uid=86954">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet unavailable" title="OMIM">O</span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&from_uid=86954" ref="ncbi_uid=86954">V</a></span></span><span class="TLline">Malignant lymphoma, large B-cell, diffuse</span></li></ul></div></div></div></div></div><div id="tabMGEN"><div class="ds_tree"><ul><li><span class="TLline"><a href="/medgen/86953" ref="tree=MeSH" title="MedGen record for B-cell lymphoma">B-cell lymphoma</a></span><ul><li><span class="TLline"><a href="/medgen/86953" ref="tree=MeSH" title="MedGen record for B-cell lymphoma">B-cell lymphoma</a></span><ul><li><span class="TLline"><a href="/medgen/86953" ref="tree=MeSH" title="MedGen record for B-cell lymphoma">B-cell lymphoma</a></span><ul><li><span class="TLline"><a href="/medgen/86953" ref="tree=MeSH" title="MedGen record for B-cell lymphoma">B-cell lymphoma</a></span><ul><li><span class="TLline"><a href="/medgen/86953" ref="tree=MeSH" title="MedGen record for B-cell lymphoma">B-cell lymphoma</a></span><ul><li><span class="TLline"><a href="/medgen/86953" ref="tree=MeSH" title="MedGen record for B-cell lymphoma">B-cell lymphoma</a></span><ul><li><span class="matched_ds">Malignant lymphoma, large B-cell, diffuse</span><ul><li><span class="TLline"><a href="/medgen/233964" ref="tree=MeSH" title="MedGen record for Adult Diffuse Large B-Cell Lymphoma">Adult Diffuse Large B-Cell Lymphoma</a></span><ul><li><span class="TLline"><a href="/medgen/853349" ref="tree=MeSH" title="MedGen record for Adult Grade III Lymphomatoid Granulomatosis">Adult Grade III Lymphomatoid Granulomatosis</a></span><ul><li><span class="TLline"><a href="/medgen/853350" ref="tree=MeSH" title="MedGen record for Recurrent Adult Grade III Lymphomatoid Granulomatosis">Recurrent Adult Grade III Lymphomatoid Granulomatosis</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/78883" ref="tree=MeSH" title="MedGen record for Adult Immunoblastic Lymphoma">Adult Immunoblastic Lymphoma</a></span><ul><li><span class="TLline"><a href="/medgen/124680" ref="tree=MeSH" title="MedGen record for Ann Arbor Stage I Adult Immunoblastic Lymphoma">Ann Arbor Stage I Adult Immunoblastic Lymphoma</a></span></li><li><span class="TLline"><a href="/medgen/83607" ref="tree=MeSH" title="MedGen record for Ann Arbor Stage II Adult Immunoblastic Lymphoma">Ann Arbor Stage II Adult Immunoblastic Lymphoma</a></span></li><li><span class="TLline"><a href="/medgen/76078" ref="tree=MeSH" title="MedGen record for Ann Arbor Stage III Adult Immunoblastic Lymphoma">Ann Arbor Stage III Adult Immunoblastic Lymphoma</a></span></li><li><span class="TLline"><a href="/medgen/124707" ref="tree=MeSH" title="MedGen record for Ann Arbor Stage IV Adult Immunoblastic Lymphoma">Ann Arbor Stage IV Adult Immunoblastic Lymphoma</a></span></li><li><span class="TLline"><a href="/medgen/124711" ref="tree=MeSH" title="MedGen record for Recurrent Adult Immunoblastic Lymphoma">Recurrent Adult Immunoblastic Lymphoma</a></span></li></ul></li></ul></li><li><span class="TLline"><a href="/medgen/1727043" ref="tree=MeSH" title="MedGen record for Advanced Diffuse Large B-Cell Lymphoma">Advanced Diffuse Large B-Cell Lymphoma</a></span></li><li><span class="TLline"><a href="/medgen/231001" ref="tree=MeSH" title="MedGen record for AIDS-Related Diffuse Large B-cell Lymphoma">AIDS-Related Diffuse Large B-cell Lymphoma</a></span><ul><li><span class="TLline"><a href="/medgen/233109" ref="tree=MeSH" title="MedGen record for AIDS-Related Diffuse Large B-Cell Lymphoma Arising in HHV8-Positive Multicentric Castleman Disease">AIDS-Related Diffuse Large B-Cell Lymphoma Arising in HHV8-Positive Multicentric Castleman Disease</a></span></li><li><span class="TLline"><a href="/medgen/314042" ref="tree=MeSH" title="MedGen record for AIDS-Related Immunoblastic Lymphoma">AIDS-Related Immunoblastic Lymphoma</a></span></li><li><span class="TLline"><a href="/medgen/233110" ref="tree=MeSH" title="MedGen record for AIDS-Related Plasmablastic Lymphoma">AIDS-Related Plasmablastic Lymphoma</a></span><ul><li><span class="TLline"><a href="/medgen/231327" ref="tree=MeSH" title="MedGen record for AIDS-Related Plasmablastic Lymphoma of Mucosa Site">AIDS-Related Plasmablastic Lymphoma of Mucosa Site</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/231329" ref="tree=MeSH" title="MedGen record for AIDS-Related Primary Effusion Lymphoma">AIDS-Related Primary Effusion Lymphoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/232429" ref="tree=MeSH" title="MedGen record for ALK-positive large B-cell lymphoma">ALK-positive large B-cell lymphoma</a></span></li><li><span class="TLline"><a href="/medgen/267764" ref="tree=MeSH" title="MedGen record for Breast diffuse large B-cell lymphoma">Breast diffuse large B-cell lymphoma</a></span></li><li><span class="TLline"><a href="/medgen/234127" ref="tree=MeSH" title="MedGen record for Childhood Diffuse Large B-Cell Lymphoma">Childhood Diffuse Large B-Cell Lymphoma</a></span><ul><li><span class="TLline"><a href="/medgen/853345" ref="tree=MeSH" title="MedGen record for Childhood Grade III Lymphomatoid Granulomatosis">Childhood Grade III Lymphomatoid Granulomatosis</a></span><ul><li><span class="TLline"><a href="/medgen/853346" ref="tree=MeSH" title="MedGen record for Recurrent Childhood Grade III Lymphomatoid Granulomatosis">Recurrent Childhood Grade III Lymphomatoid Granulomatosis</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/78890" ref="tree=MeSH" title="MedGen record for Childhood Immunoblastic Lymphoma">Childhood Immunoblastic Lymphoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/1786523" ref="tree=MeSH" title="MedGen record for Conjunctival Diffuse Large B-Cell Lymphoma">Conjunctival Diffuse Large B-Cell Lymphoma</a></span></li><li><span class="TLline"><a href="/medgen/758641" ref="tree=MeSH" title="MedGen record for Diffuse Large B-Cell Lymphoma Arising in HHV8-Positive Multicentric Castleman Disease">Diffuse Large B-Cell Lymphoma Arising in HHV8-Positive Multicentric Castleman Disease</a></span></li><li><span class="TLline"><a href="/medgen/397630" ref="tree=MeSH" title="MedGen record for Diffuse Large B-Cell Lymphoma Associated with Chronic Inflammation">Diffuse Large B-Cell Lymphoma Associated with Chronic Inflammation</a></span><ul><li><span class="TLline"><a href="/medgen/1651523" ref="tree=MeSH" title="MedGen record for Fibrin-Associated Diffuse Large B-Cell Lymphoma">Fibrin-Associated Diffuse Large B-Cell Lymphoma</a></span></li><li><span class="TLline"><a href="/medgen/313646" ref="tree=MeSH" title="MedGen record for Pyothorax-Associated Lymphoma">Pyothorax-Associated Lymphoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/1644436" ref="tree=MeSH" title="MedGen record for Diffuse Large B-Cell Lymphoma by Ann Arbor Stage">Diffuse Large B-Cell Lymphoma by Ann Arbor Stage</a></span><ul><li><span class="TLline"><a href="/medgen/163606" ref="tree=MeSH" title="MedGen record for Ann Arbor Stage I Diffuse Large B-Cell Lymphoma">Ann Arbor Stage I Diffuse Large B-Cell Lymphoma</a></span><ul><li><span class="TLline"><a href="/medgen/209012" ref="tree=MeSH" title="MedGen record for Ann Arbor Stage I Centroblastic Lymphoma">Ann Arbor Stage I Centroblastic Lymphoma</a></span></li><li><span class="TLline"><a href="/medgen/167775" ref="tree=MeSH" title="MedGen record for Ann Arbor Stage I Primary Mediastinal Large B-Cell Lymphoma">Ann Arbor Stage I Primary Mediastinal Large B-Cell Lymphoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/167770" ref="tree=MeSH" title="MedGen record for Ann Arbor Stage II Diffuse Large B-Cell Lymphoma">Ann Arbor Stage II Diffuse Large B-Cell Lymphoma</a></span><ul><li><span class="TLline"><a href="/medgen/209013" ref="tree=MeSH" title="MedGen record for Ann Arbor Stage II Centroblastic Lymphoma">Ann Arbor Stage II Centroblastic Lymphoma</a></span></li><li><span class="TLline"><a href="/medgen/167776" ref="tree=MeSH" title="MedGen record for Ann Arbor Stage II Primary Mediastinal Large B-Cell Lymphoma">Ann Arbor Stage II Primary Mediastinal Large B-Cell Lymphoma</a></span></li><li><span class="TLline"><a href="/medgen/1741112" ref="tree=MeSH" title="MedGen record for Ann Arbor Stage IIX (Bulky) Diffuse Large B-Cell Lymphoma">Ann Arbor Stage IIX (Bulky) Diffuse Large B-Cell Lymphoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/167771" ref="tree=MeSH" title="MedGen record for Ann Arbor Stage III Diffuse Large B-Cell Lymphoma">Ann Arbor Stage III Diffuse Large B-Cell Lymphoma</a></span><ul><li><span class="TLline"><a href="/medgen/163657" ref="tree=MeSH" title="MedGen record for Ann Arbor Stage III Centroblastic Lymphoma">Ann Arbor Stage III Centroblastic Lymphoma</a></span></li><li><span class="TLline"><a href="/medgen/167777" ref="tree=MeSH" title="MedGen record for Ann Arbor Stage III Primary Mediastinal Large B-Cell Lymphoma">Ann Arbor Stage III Primary Mediastinal Large B-Cell Lymphoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/167772" ref="tree=MeSH" title="MedGen record for Ann Arbor Stage IV Diffuse Large B-Cell Lymphoma">Ann Arbor Stage IV Diffuse Large B-Cell Lymphoma</a></span><ul><li><span class="TLline"><a href="/medgen/163572" ref="tree=MeSH" title="MedGen record for Ann Arbor Stage IV Centroblastic Lymphoma">Ann Arbor Stage IV Centroblastic Lymphoma</a></span></li><li><span class="TLline"><a href="/medgen/167778" ref="tree=MeSH" title="MedGen record for Ann Arbor Stage IV Primary Mediastinal Large B-Cell Lymphoma">Ann Arbor Stage IV Primary Mediastinal Large B-Cell Lymphoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/1633137" ref="tree=MeSH" title="MedGen record for Centroblastic Lymphoma by Ann Arbor Stage">Centroblastic Lymphoma by Ann Arbor Stage</a></span></li><li><span class="TLline"><a href="/medgen/1647898" ref="tree=MeSH" title="MedGen record for Primary Mediastinal Large B-Cell Lymphoma by Ann Arbor Stage">Primary Mediastinal Large B-Cell Lymphoma by Ann Arbor Stage</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/378339" ref="tree=MeSH" title="MedGen record for Diffuse large B-cell lymphoma of the central nervous system">Diffuse large B-cell lymphoma of the central nervous system</a></span><ul><li><span class="TLline"><a href="/medgen/1391195" ref="tree=MeSH" title="MedGen record for Central Nervous System Intravascular Large B-Cell Lymphoma">Central Nervous System Intravascular Large B-Cell Lymphoma</a></span></li><li><span class="TLline"><a href="/medgen/1648726" ref="tree=MeSH" title="MedGen record for Pituitary Gland Diffuse Large B-Cell Lymphoma">Pituitary Gland Diffuse Large B-Cell Lymphoma</a></span></li><li><span class="TLline"><a href="/medgen/1678525" ref="tree=MeSH" title="MedGen record for Primary Vitreoretinal Diffuse Large B-Cell Lymphoma">Primary Vitreoretinal Diffuse Large B-Cell Lymphoma</a></span><ul><li><span class="TLline"><a href="/medgen/1684136" ref="tree=MeSH" title="MedGen record for Recurrent Primary Vitreoretinal Diffuse Large B-Cell Lymphoma">Recurrent Primary Vitreoretinal Diffuse Large B-Cell Lymphoma</a></span></li><li><span class="TLline"><a href="/medgen/1683653" ref="tree=MeSH" title="MedGen record for Refractory Primary Vitreoretinal Diffuse Large B-Cell Lymphoma">Refractory Primary Vitreoretinal Diffuse Large B-Cell Lymphoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/1675182" ref="tree=MeSH" title="MedGen record for Recurrent Primary Diffuse Large B-Cell Lymphoma of the Central Nervous System">Recurrent Primary Diffuse Large B-Cell Lymphoma of the Central Nervous System</a></span></li><li><span class="TLline"><a href="/medgen/1677524" ref="tree=MeSH" title="MedGen record for Refractory Primary Diffuse Large B-Cell Lymphoma of the Central Nervous System">Refractory Primary Diffuse Large B-Cell Lymphoma of the Central Nervous System</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/272544" ref="tree=MeSH" title="MedGen record for Diffuse Large B-Cell Lymphoma Post-Transplant Lymphoproliferative Disorder">Diffuse Large B-Cell Lymphoma Post-Transplant Lymphoproliferative Disorder</a></span><ul><li><span class="TLline"><a href="/medgen/233984" ref="tree=MeSH" title="MedGen record for Anaplastic Lymphoma Post-Transplant Lymphoproliferative Disorder">Anaplastic Lymphoma Post-Transplant Lymphoproliferative Disorder</a></span></li><li><span class="TLline"><a href="/medgen/272447" ref="tree=MeSH" title="MedGen record for Centroblastic Lymphoma Post-Transplant Lymphoproliferative Disorder">Centroblastic Lymphoma Post-Transplant Lymphoproliferative Disorder</a></span></li><li><span class="TLline"><a href="/medgen/232639" ref="tree=MeSH" title="MedGen record for Immunoblastic Lymphoma Post-Transplant Lymphoproliferative Disorder">Immunoblastic Lymphoma Post-Transplant Lymphoproliferative Disorder</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/1374328" ref="tree=MeSH" title="MedGen record for Diffuse large B-cell lymphoma with chronic inflammation">Diffuse large B-cell lymphoma with chronic inflammation</a></span></li><li><span class="TLline"><a href="/medgen/397631" ref="tree=MeSH" title="MedGen record for Diffuse Large B-Cell Lymphoma, Not Otherwise Specified">Diffuse Large B-Cell Lymphoma, Not Otherwise Specified</a></span><ul><li><span class="TLline"><a href="/medgen/272106" ref="tree=MeSH" title="MedGen record for Anaplastic Lymphoma">Anaplastic Lymphoma</a></span></li><li><span class="TLline"><a href="/medgen/90149" ref="tree=MeSH" title="MedGen record for Centroblastic Lymphoma">Centroblastic Lymphoma</a></span><ul><li><span class="TLline"><a href="/medgen/167822" ref="tree=MeSH" title="MedGen record for Recurrent Centroblastic Lymphoma">Recurrent Centroblastic Lymphoma</a></span></li><li><span class="TLline"><a href="/medgen/167823" ref="tree=MeSH" title="MedGen record for Refractory Centroblastic Lymphoma">Refractory Centroblastic Lymphoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/313111" ref="tree=MeSH" title="MedGen record for Diffuse Large B-Cell Lymphoma, Not Otherwise Specified by Gene Expression Profile">Diffuse Large B-Cell Lymphoma, Not Otherwise Specified by Gene Expression Profile</a></span><ul><li><span class="TLline"><a href="/medgen/272545" ref="tree=MeSH" title="MedGen record for Diffuse large B-cell lymphoma activated B-cell type">Diffuse large B-cell lymphoma activated B-cell type</a></span></li><li><span class="TLline"><a href="/medgen/234202" ref="tree=MeSH" title="MedGen record for Diffuse large B-cell lymphoma germinal center B-cell type">Diffuse large B-cell lymphoma germinal center B-cell type</a></span></li><li><span class="TLline"><a href="/medgen/318287" ref="tree=MeSH" title="MedGen record for Diffuse Large B-Cell Lymphoma Unclassifiable">Diffuse Large B-Cell Lymphoma Unclassifiable</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/1665285" ref="tree=MeSH" title="MedGen record for Diffuse Large B-Cell Lymphoma, Not Otherwise Specified Molecular Subtypes">Diffuse Large B-Cell Lymphoma, Not Otherwise Specified Molecular Subtypes</a></span><ul><li><span class="TLline"><a href="/medgen/1650982" ref="tree=MeSH" title="MedGen record for BN2 diffuse large B-cell lymphoma">BN2 diffuse large B-cell lymphoma</a></span></li><li><span class="TLline"><a href="/medgen/1653316" ref="tree=MeSH" title="MedGen record for EZB diffuse large B-cell lymphoma">EZB diffuse large B-cell lymphoma</a></span></li><li><span class="TLline"><a href="/medgen/1669702" ref="tree=MeSH" title="MedGen record for MCD diffuse large B-cell lymphoma">MCD diffuse large B-cell lymphoma</a></span></li><li><span class="TLline"><a href="/medgen/1650336" ref="tree=MeSH" title="MedGen record for N1 diffuse large B-cell lymphoma">N1 diffuse large B-cell lymphoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/86955" ref="tree=MeSH" title="MedGen record for Large-cell immunoblastic lymphoma">Large-cell immunoblastic lymphoma</a></span><ul><li><span class="TLline"><a href="/medgen/237010" ref="tree=MeSH" title="MedGen record for Thyroid Gland Immunoblastic Lymphoma">Thyroid Gland Immunoblastic Lymphoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/1720486" ref="tree=MeSH" title="MedGen record for Recurrent Diffuse Large B-Cell Lymphoma, Not Otherwise Specified">Recurrent Diffuse Large B-Cell Lymphoma, Not Otherwise Specified</a></span><ul><li><span class="TLline"><a href="/medgen/1689554" ref="tree=MeSH" title="MedGen record for Recurrent Diffuse Large B-Cell Lymphoma Activated B-Cell Type">Recurrent Diffuse Large B-Cell Lymphoma Activated B-Cell Type</a></span></li><li><span class="TLline"><a href="/medgen/1691307" ref="tree=MeSH" title="MedGen record for Recurrent Diffuse Large B-Cell Lymphoma Germinal Center B-Cell Type">Recurrent Diffuse Large B-Cell Lymphoma Germinal Center B-Cell Type</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/1718561" ref="tree=MeSH" title="MedGen record for Refractory Diffuse Large B-Cell Lymphoma, Not Otherwise Specified">Refractory Diffuse Large B-Cell Lymphoma, Not Otherwise Specified</a></span><ul><li><span class="TLline"><a href="/medgen/1706089" ref="tree=MeSH" title="MedGen record for Refractory Diffuse Large B-Cell Lymphoma Activated B-Cell Type">Refractory Diffuse Large B-Cell Lymphoma Activated B-Cell Type</a></span></li><li><span class="TLline"><a href="/medgen/1697485" ref="tree=MeSH" title="MedGen record for Refractory Diffuse Large B-Cell Lymphoma Germinal Center B-Cell Type">Refractory Diffuse Large B-Cell Lymphoma Germinal Center B-Cell Type</a></span></li></ul></li></ul></li><li><span class="TLline"><a href="/medgen/1737635" ref="tree=MeSH" title="MedGen record for Digestive System Diffuse Large B-Cell Lymphoma">Digestive System Diffuse Large B-Cell Lymphoma</a></span><ul><li><span class="TLline"><a href="/medgen/474460" ref="tree=MeSH" title="MedGen record for Colorectal diffuse large B-cell lymphoma">Colorectal diffuse large B-cell lymphoma</a></span><ul><li><span class="TLline"><a href="/medgen/474461" ref="tree=MeSH" title="MedGen record for Colon Diffuse Large B-Cell Lymphoma">Colon Diffuse Large B-Cell Lymphoma</a></span></li><li><span class="TLline"><a href="/medgen/474458" ref="tree=MeSH" title="MedGen record for Colorectal High Grade B-Cell Lymphoma, Not Otherwise Specified">Colorectal High Grade B-Cell Lymphoma, Not Otherwise Specified</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/459494" ref="tree=MeSH" title="MedGen record for Esophageal Diffuse Large B-Cell Lymphoma">Esophageal Diffuse Large B-Cell Lymphoma</a></span></li><li><span class="TLline"><a href="/medgen/277530" ref="tree=MeSH" title="MedGen record for Gastric diffuse large B-cell lymphoma">Gastric diffuse large B-cell lymphoma</a></span></li><li><span class="TLline"><a href="/medgen/473542" ref="tree=MeSH" title="MedGen record for Liver diffuse large B-cell lymphoma">Liver diffuse large B-cell lymphoma</a></span></li><li><span class="TLline"><a href="/medgen/474155" ref="tree=MeSH" title="MedGen record for Small intestinal diffuse large B-cell lymphoma">Small intestinal diffuse large B-cell lymphoma</a></span><ul><li><span class="TLline"><a href="/medgen/474157" ref="tree=MeSH" title="MedGen record for Small Intestinal High Grade B-Cell Lymphoma, Not Otherwise Specified">Small Intestinal High Grade B-Cell Lymphoma, Not Otherwise Specified</a></span></li></ul></li></ul></li><li><span class="TLline"><a href="/medgen/1621606" ref="tree=MeSH" title="MedGen record for Double-Expressor Lymphoma">Double-Expressor Lymphoma</a></span></li><li><span class="TLline"><a href="/medgen/397690" ref="tree=MeSH" title="MedGen record for Epstein-Barr virus-positive diffuse large B-cell lymphoma of the elderly">Epstein-Barr virus-positive diffuse large B-cell lymphoma of the elderly</a></span><ul><li><span class="TLline"><a href="/medgen/1670225" ref="tree=MeSH" title="MedGen record for Recurrent EBV-Positive Diffuse Large B-Cell Lymphoma, Not Otherwise Specified">Recurrent EBV-Positive Diffuse Large B-Cell Lymphoma, Not Otherwise Specified</a></span></li><li><span class="TLline"><a href="/medgen/1669009" ref="tree=MeSH" title="MedGen record for Refractory EBV-Positive Diffuse Large B-Cell Lymphoma, Not Otherwise Specified">Refractory EBV-Positive Diffuse Large B-Cell Lymphoma, Not Otherwise Specified</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/78928" ref="tree=MeSH" title="MedGen record for Grade III lymphomatoid granulomatosis">Grade III lymphomatoid granulomatosis</a></span><ul><li><span class="TLline"><a href="/medgen/378769" ref="tree=MeSH" title="MedGen record for Recurrent Grade III Lymphomatoid Granulomatosis">Recurrent Grade III Lymphomatoid Granulomatosis</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/1615300" ref="tree=MeSH" title="MedGen record for HHV8-Positive Diffuse Large B-Cell Lymphoma, Not Otherwise Specified">HHV8-Positive Diffuse Large B-Cell Lymphoma, Not Otherwise Specified</a></span></li><li><span class="TLline"><a href="/medgen/629622" ref="tree=MeSH" title="MedGen record for High grade B-cell lymphoma">High grade B-cell lymphoma</a></span><ul><li><span class="TLline"><a href="/medgen/1617477" ref="tree=MeSH" title="MedGen record for High grade B-cell lymphoma with MYC and/ or BCL2 and/or BCL6 rearrangement">High grade B-cell lymphoma with MYC and/ or BCL2 and/or BCL6 rearrangement</a></span><ul><li><span class="TLline"><a href="/medgen/925047" ref="tree=MeSH" title="MedGen record for High Grade B-Cell Lymphoma with MYC and BCL2 or BCL6 Rearrangements">High Grade B-Cell Lymphoma with MYC and BCL2 or BCL6 Rearrangements</a></span></li><li><span class="TLline"><a href="/medgen/1388063" ref="tree=MeSH" title="MedGen record for High Grade B-Cell Lymphoma with MYC, BCL2, and BCL6 Rearrangements">High Grade B-Cell Lymphoma with MYC, BCL2, and BCL6 Rearrangements</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/395909" ref="tree=MeSH" title="MedGen record for High Grade B-Cell Lymphoma, Not Otherwise Specified">High Grade B-Cell Lymphoma, Not Otherwise Specified</a></span></li><li><span class="TLline"><a href="/medgen/1703743" ref="tree=MeSH" title="MedGen record for Recurrent High Grade B-Cell Lymphoma">Recurrent High Grade B-Cell Lymphoma</a></span><ul><li><span class="TLline"><a href="/medgen/1648864" ref="tree=MeSH" title="MedGen record for Recurrent High Grade B-Cell Lymphoma with MYC and BCL2 or BCL6 Rearrangements">Recurrent High Grade B-Cell Lymphoma with MYC and BCL2 or BCL6 Rearrangements</a></span></li><li><span class="TLline"><a href="/medgen/1685560" ref="tree=MeSH" title="MedGen record for Recurrent High Grade B-Cell Lymphoma with MYC, BCL2, and BCL6 Rearrangements">Recurrent High Grade B-Cell Lymphoma with MYC, BCL2, and BCL6 Rearrangements</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/1701508" ref="tree=MeSH" title="MedGen record for Refractory High Grade B-Cell Lymphoma">Refractory High Grade B-Cell Lymphoma</a></span><ul><li><span class="TLline"><a href="/medgen/1665989" ref="tree=MeSH" title="MedGen record for Refractory High Grade B-Cell Lymphoma with MYC and BCL2 or BCL6 Rearrangements">Refractory High Grade B-Cell Lymphoma with MYC and BCL2 or BCL6 Rearrangements</a></span></li><li><span class="TLline"><a href="/medgen/1700179" ref="tree=MeSH" title="MedGen record for Refractory High Grade B-Cell Lymphoma with MYC, BCL2, and BCL6 Rearrangements">Refractory High Grade B-Cell Lymphoma with MYC, BCL2, and BCL6 Rearrangements</a></span></li></ul></li></ul></li><li><span class="TLline"><a href="/medgen/90821" ref="tree=MeSH" title="MedGen record for Intravascular large B-cell lymphoma">Intravascular large B-cell lymphoma</a></span><ul><li><span class="TLline"><a href="/medgen/313615" ref="tree=MeSH" title="MedGen record for Primary Cutaneous Intravascular Large B-Cell Lymphoma">Primary Cutaneous Intravascular Large B-Cell Lymphoma</a></span></li><li><span class="TLline"><a href="/medgen/1625943" ref="tree=MeSH" title="MedGen record for Recurrent Intravascular Large B-Cell Lymphoma">Recurrent Intravascular Large B-Cell Lymphoma</a></span></li><li><span class="TLline"><a href="/medgen/1626290" ref="tree=MeSH" title="MedGen record for Refractory Intravascular Large B-Cell Lymphoma">Refractory Intravascular Large B-Cell Lymphoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/364318" ref="tree=MeSH" title="MedGen record for Kidney Diffuse Large B-Cell Lymphoma">Kidney Diffuse Large B-Cell Lymphoma</a></span></li><li><span class="TLline"><a href="/medgen/1787161" ref="tree=MeSH" title="MedGen record for Lacrimal System Diffuse Large B-Cell Lymphoma">Lacrimal System Diffuse Large B-Cell Lymphoma</a></span><ul><li><span class="TLline"><a href="/medgen/1785748" ref="tree=MeSH" title="MedGen record for Lacrimal Drainage System Diffuse Large B-Cell Lymphoma">Lacrimal Drainage System Diffuse Large B-Cell Lymphoma</a></span></li><li><span class="TLline"><a href="/medgen/1784317" ref="tree=MeSH" title="MedGen record for Lacrimal Gland Diffuse Large B-Cell Lymphoma">Lacrimal Gland Diffuse Large B-Cell Lymphoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/6161" ref="tree=MeSH" title="MedGen record for Lymphomatoid granulomatosis">Lymphomatoid granulomatosis</a></span><ul><li><span class="TLline"><a href="/medgen/888853" ref="tree=MeSH" title="MedGen record for Childhood Lymphomatoid Granulomatosis">Childhood Lymphomatoid Granulomatosis</a></span><ul><li><span class="TLline"><a href="/medgen/883610" ref="tree=MeSH" title="MedGen record for Recurrent Childhood Lymphomatoid Granulomatosis">Recurrent Childhood Lymphomatoid Granulomatosis</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/317554" ref="tree=MeSH" title="MedGen record for Cutaneous Lymphomatoid Granulomatosis">Cutaneous Lymphomatoid Granulomatosis</a></span></li><li><span class="TLline"><a href="/medgen/83443" ref="tree=MeSH" title="MedGen record for Grade I lymphomatoid granulomatosis">Grade I lymphomatoid granulomatosis</a></span><ul><li><span class="TLline"><a href="/medgen/853347" ref="tree=MeSH" title="MedGen record for Recurrent Grade I Lymphomatoid Granulomatosis">Recurrent Grade I Lymphomatoid Granulomatosis</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/167833" ref="tree=MeSH" title="MedGen record for Grade II lymphomatoid granulomatosis">Grade II lymphomatoid granulomatosis</a></span><ul><li><span class="TLline"><a href="/medgen/853348" ref="tree=MeSH" title="MedGen record for Recurrent Grade II Lymphomatoid Granulomatosis">Recurrent Grade II Lymphomatoid Granulomatosis</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/75923" ref="tree=MeSH" title="MedGen record for Recurrent Lymphomatoid Granulomatosis">Recurrent Lymphomatoid Granulomatosis</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/235324" ref="tree=MeSH" title="MedGen record for Methotrexate-Associated Diffuse Large B-Cell Lymphoma">Methotrexate-Associated Diffuse Large B-Cell Lymphoma</a></span></li><li><span class="TLline"><a href="/medgen/235460" ref="tree=MeSH" title="MedGen record for Paranasal Sinus Diffuse Large B-Cell Lymphoma">Paranasal Sinus Diffuse Large B-Cell Lymphoma</a></span></li><li><span class="TLline"><a href="/medgen/483338" ref="tree=MeSH" title="MedGen record for Plasmablastic lymphoma">Plasmablastic lymphoma</a></span><ul><li><span class="TLline"><a href="/medgen/233861" ref="tree=MeSH" title="MedGen record for Plasmablastic Lymphoma of Mucosa Site">Plasmablastic Lymphoma of Mucosa Site</a></span><ul><li><span class="TLline"><a href="/medgen/396465" ref="tree=MeSH" title="MedGen record for Oral Cavity Plasmablastic Lymphoma">Oral Cavity Plasmablastic Lymphoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/354078" ref="tree=MeSH" title="MedGen record for Primary Cutaneous Plasmablastic Lymphoma">Primary Cutaneous Plasmablastic Lymphoma</a></span></li><li><span class="TLline"><a href="/medgen/1681920" ref="tree=MeSH" title="MedGen record for Recurrent Plasmablastic Lymphoma">Recurrent Plasmablastic Lymphoma</a></span></li><li><span class="TLline"><a href="/medgen/1675391" ref="tree=MeSH" title="MedGen record for Refractory Plasmablastic Lymphoma">Refractory Plasmablastic Lymphoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/698597" ref="tree=MeSH" title="MedGen record for Primary Cutaneous Diffuse Large B-Cell Lymphoma">Primary Cutaneous Diffuse Large B-Cell Lymphoma</a></span><ul><li><span class="TLline"><a href="/medgen/311155" ref="tree=MeSH" title="MedGen record for Primary cutaneous diffuse large B-cell lymphoma, Leg type">Primary cutaneous diffuse large B-cell lymphoma, Leg type</a></span><ul><li><span class="TLline"><a href="/medgen/1624768" ref="tree=MeSH" title="MedGen record for Recurrent Primary Cutaneous Diffuse Large B-Cell Lymphoma, Leg Type">Recurrent Primary Cutaneous Diffuse Large B-Cell Lymphoma, Leg Type</a></span></li><li><span class="TLline"><a href="/medgen/1618756" ref="tree=MeSH" title="MedGen record for Refractory Primary Cutaneous Diffuse Large B-Cell Lymphoma, Leg Type">Refractory Primary Cutaneous Diffuse Large B-Cell Lymphoma, Leg Type</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/354077" ref="tree=MeSH" title="MedGen record for Primary Cutaneous Diffuse Large B-Cell Lymphoma, Other">Primary Cutaneous Diffuse Large B-Cell Lymphoma, Other</a></span><ul><li><span class="TLline"><a href="/medgen/313616" ref="tree=MeSH" title="MedGen record for Primary Cutaneous T-Cell/Histiocyte-Rich Large B-Cell Lymphoma">Primary Cutaneous T-Cell/Histiocyte-Rich Large B-Cell Lymphoma</a></span></li></ul></li></ul></li><li><span class="TLline"><a href="/medgen/220953" ref="tree=MeSH" title="MedGen record for Primary effusion lymphoma">Primary effusion lymphoma</a></span><ul><li><span class="TLline"><a href="/medgen/1669221" ref="tree=MeSH" title="MedGen record for Body Cavity Primary Effusion Lymphoma">Body Cavity Primary Effusion Lymphoma</a></span></li><li><span class="TLline"><a href="/medgen/1666925" ref="tree=MeSH" title="MedGen record for Extracavitary Primary Effusion Lymphoma">Extracavitary Primary Effusion Lymphoma</a></span></li><li><span class="TLline"><a href="/medgen/1673067" ref="tree=MeSH" title="MedGen record for Recurrent Primary Effusion Lymphoma">Recurrent Primary Effusion Lymphoma</a></span></li><li><span class="TLline"><a href="/medgen/1676531" ref="tree=MeSH" title="MedGen record for Refractory Primary Effusion Lymphoma">Refractory Primary Effusion Lymphoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/714984" ref="tree=MeSH" title="MedGen record for Primary mediastinal large B-cell lymphoma">Primary mediastinal large B-cell lymphoma</a></span><ul><li><span class="TLline"><a href="/medgen/163527" ref="tree=MeSH" title="MedGen record for Recurrent Primary Mediastinal Large B-Cell Lymphoma">Recurrent Primary Mediastinal Large B-Cell Lymphoma</a></span></li><li><span class="TLline"><a href="/medgen/163528" ref="tree=MeSH" title="MedGen record for Refractory Primary Mediastinal Large B-Cell Lymphoma">Refractory Primary Mediastinal Large B-Cell Lymphoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/1789549" ref="tree=MeSH" title="MedGen record for Primary pulmonary diffuse large B-cell lymphoma">Primary pulmonary diffuse large B-cell lymphoma</a></span></li><li><span class="TLline"><a href="/medgen/1701031" ref="tree=MeSH" title="MedGen record for Prostate Diffuse Large B-Cell Lymphoma">Prostate Diffuse Large B-Cell Lymphoma</a></span></li><li><span class="TLline"><a href="/medgen/163605" ref="tree=MeSH" title="MedGen record for Recurrent Diffuse Large B-Cell Lymphoma">Recurrent Diffuse Large B-Cell Lymphoma</a></span><ul><li><span class="TLline"><a href="/medgen/1620786" ref="tree=MeSH" title="MedGen record for Recurrent Extranodal Diffuse Large B-cell Lymphoma">Recurrent Extranodal Diffuse Large B-cell Lymphoma</a></span></li><li><span class="TLline"><a href="/medgen/1661682" ref="tree=MeSH" title="MedGen record for Recurrent T-Cell/Histiocyte-Rich Large B-Cell Lymphoma">Recurrent T-Cell/Histiocyte-Rich Large B-Cell Lymphoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/208957" ref="tree=MeSH" title="MedGen record for Relapsed/refractory diffuse large B-cell lymphoma">Relapsed/refractory diffuse large B-cell lymphoma</a></span><ul><li><span class="TLline"><a href="/medgen/1624258" ref="tree=MeSH" title="MedGen record for Refractory Extranodal Diffuse Large B-cell Lymphoma">Refractory Extranodal Diffuse Large B-cell Lymphoma</a></span></li><li><span class="TLline"><a href="/medgen/1680847" ref="tree=MeSH" title="MedGen record for Refractory T-Cell/Histiocyte-Rich Large B-Cell Lymphoma">Refractory T-Cell/Histiocyte-Rich Large B-Cell Lymphoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/1730404" ref="tree=MeSH" title="MedGen record for Salivary Gland Diffuse Large B-Cell Lymphoma">Salivary Gland Diffuse Large B-Cell Lymphoma</a></span><ul><li><span class="TLline"><a href="/medgen/1722104" ref="tree=MeSH" title="MedGen record for Parotid Gland Diffuse Large B-Cell Lymphoma">Parotid Gland Diffuse Large B-Cell Lymphoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/412154" ref="tree=MeSH" title="MedGen record for Splenic diffuse large B-cell lymphoma">Splenic diffuse large B-cell lymphoma</a></span></li><li><span class="TLline"><a href="/medgen/232943" ref="tree=MeSH" title="MedGen record for T-cell/histiocyte rich large B cell lymphoma">T-cell/histiocyte rich large B cell lymphoma</a></span></li><li><span class="TLline"><a href="/medgen/1693324" ref="tree=MeSH" title="MedGen record for Testicular Diffuse Large B-Cell Lymphoma">Testicular Diffuse Large B-Cell Lymphoma</a></span></li><li><span class="TLline"><a href="/medgen/234429" ref="tree=MeSH" title="MedGen record for Thyroid gland diffuse large B-cell lymphoma">Thyroid gland diffuse large B-cell lymphoma</a></span></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></div></div><div id="tabORDO">Follow <a target="_blank" href="http://www.orpha.net/consor/cgi-bin/Disease_Classif.php?lng=EN&data_id=156&PatId=8749&search=Disease_Classif_Simple&new=1" class="ital bold">this link</a> to review classifications for <span class="ital">Malignant lymphoma, large B-cell, diffuse</span> in Orphanet.</div></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_105">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Professional_guidelines">Professional guidelines</h1><a sid="105" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">PubMed<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpPM"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/37322012">Primary central nervous system lymphoma.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Ferreri AJM,
|
||
Calimeri T,
|
||
Cwynarski K,
|
||
Dietrich J,
|
||
Grommes C,
|
||
Hoang-Xuan K,
|
||
Hu LS,
|
||
Illerhaus G,
|
||
Nayak L,
|
||
Ponzoni M,
|
||
Batchelor TT</span><br />
|
||
<span class="medgenPMjournal">Nat Rev Dis Primers</span>
|
||
2023 Jun 15;9(1):29.
|
||
doi: 10.1038/s41572-023-00439-0.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37322012" target="_blank">37322012</a><a href="/pmc/articles/PMC10637780" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/36255040">Follicular lymphoma: 2023 update on diagnosis and management.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Jacobsen E</span><br />
|
||
<span class="medgenPMjournal">Am J Hematol</span>
|
||
2022 Dec;97(12):1638-1651.
|
||
Epub 2022 Oct 18
|
||
doi: 10.1002/ajh.26737.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36255040" target="_blank">36255040</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/26314773">Diffuse large B-cell lymphoma (DLBCL): ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Tilly H,
|
||
Gomes da Silva M,
|
||
Vitolo U,
|
||
Jack A,
|
||
Meignan M,
|
||
Lopez-Guillermo A,
|
||
Walewski J,
|
||
André M,
|
||
Johnson PW,
|
||
Pfreundschuh M,
|
||
Ladetto M;
|
||
ESMO Guidelines Committee</span><br />
|
||
<span class="medgenPMjournal">Ann Oncol</span>
|
||
2015 Sep;26 Suppl 5:v116-25.
|
||
doi: 10.1093/annonc/mdv304.
|
||
<span class="bold">PMID: </span><a href="/pubmed/26314773" target="_blank">26314773</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(malignant%20lymphoma%2C%20large%20b-cell%2C%20diffuse)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">See all (1454)</a></div><h3 class="subhead">Curated<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpCurated"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3><h3 class="nl vspace"><a href="https://www.nccn.org/professionals/physician_gls/pdf/b-cell.pdf" target="_blank">NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) B-Cell Lymphomas, 2024</a></h3>
|
||
<h3 class="nl vspace"><a href="https://www.nccn.org/professionals/physician_gls/pdf/ped_b-cell.pdf" target="_blank">NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®), Pediatric Aggressive Mature B-Cell Lymphomas, 2024</a></h3>
|
||
</div>
|
||
</div>
|
||
<div class="display-none help-popup" id="guidelinesHelpPM">These guidelines are articles in PubMed that match specific search criteria developed by MedGen to capture the most relevant practice guidelines. This list may not be comprehensive and may include broader topics as well. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div><div class="display-none help-popup" id="guidelinesHelpCurated">These guidelines are manually curated by the MedGen team
|
||
to supplement articles available in PubMed. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div></div></div></div></div></div></div></div>
|
||
<div id="messagearea_bottom">
|
||
|
||
</div>
|
||
<div class=" bottom">
|
||
|
||
</div>
|
||
|
||
</div>
|
||
</div>
|
||
<div class="supplemental col three_col last">
|
||
<h2 class="offscreen_noflow">Supplemental Content</h2>
|
||
|
||
<div>
|
||
|
||
<!-- MedGen supplemental column starts here -->
|
||
<div class="rightCol mgCol">
|
||
<div class="portlet mgSection" id="ID_113">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Table_of_contents">Table of contents</h1><a sid="113" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><ul id="my-toc"></ul></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_106">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Genetic_Testing_Registry">Genetic Testing Registry</h1><a sid="106" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><ul><li><a href="/gtr/tests?term=C0079744%5bDISCUI%5d&filter=method%3A2%5F8" target="_blank">Deletion/duplication analysis (1)</a></li>
|
||
<li><a href="/gtr/tests?term=C0079744%5bDISCUI%5d&filter=method%3A2%5F29" target="_blank">Detection of homozygosity (1)</a></li>
|
||
<li><a href="/gtr/tests?term=C0079744%5bDISCUI%5d&filter=method%3A2%5F9" target="_blank">Sequence analysis of select exons (2)</a></li>
|
||
<li><a href="/gtr/tests?term=C0079744%5bDISCUI%5d&filter=method%3A2%5F19" target="_blank">Targeted variant analysis (2)</a></li>
|
||
<li class="portletSeeAll portletSeeAllPad"><total><a href="/gtr/tests?term=C0079744%5bDISCUI%5d" target="_blank">See all (5)</a></total></li>
|
||
</ul></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_119">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Clinical_resources">Clinical resources</h1><a sid="119" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><ul><li><a href="http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Expert=544" target="_blank">Orphanet</a></li><li><a href="https://clinicaltrials.gov/search?cond=Malignant%20lymphoma,%20large%20B-cell,%20diffuse" target="_blank">ClinicalTrials.gov</a></li></ul></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_121">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Practice_guidelines">Practice guidelines</h1><a sid="121" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><ul class="a_poppers"><li><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(malignant%20lymphoma%2C%20large%20b-cell%2C%20diffuse)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">PubMed</a><div class="help-popup">See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div></li></ul><h3 class="subhead">Curated</h3><ul class="a_poppers"><li><a target="_blank" href="https://www.nccn.org/professionals/physician_gls/pdf/b-cell.pdf">NCCN, 2024</a><div>NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) B-Cell Lymphomas, 2024</div></li><li><a target="_blank" href="https://www.nccn.org/professionals/physician_gls/pdf/ped_b-cell.pdf">NCCN, 2024</a><div>NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®), Pediatric Aggressive Mature B-Cell Lymphomas, 2024</div></li></ul></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_116">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Consumer_resources">Consumer resources</h1><a sid="116" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><ul><li><a href="https://vsearch.nlm.nih.gov/vivisimo/cgi-bin/query-meta?v:project=medlineplus&query=Malignant%20lymphoma,%20large%20B-cell,%20diffuse" target="_blank">MedlinePlus</a></li><li><a href="https://rarediseases.info.nih.gov/diseases/3178/disease" target="_blank">NCATS Office of Rare Diseases Research (GARD)</a></li></ul></div>
|
||
</div>
|
||
</div>
|
||
<div class="portlet brieflink">
|
||
<div class="portlet_head">
|
||
<div class="portlet_title">
|
||
<h3>Reviews</h3>
|
||
</div>
|
||
<a name="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_SingleItemSuplCluster.MedGenReviews.Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="Reviews" id="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_SingleItemSuplCluster.MedGenReviews.Shutter"></a>
|
||
</div>
|
||
<div class="portlet_content">
|
||
<ul>
|
||
<li>
|
||
<a href="/pubmed/clinical?term=Malignant%20lymphoma,%20large%20B-cell,%20diffuse" ref="ncbi_uid=&discoId=gtr_reviews&linkpos=1&linkpostotal=2" target="_blank">PubMed Clinical Queries</a>
|
||
</li>
|
||
<li>
|
||
<a href="/pubmed?term=Malignant%20lymphoma,%20large%20B-cell,%20diffuse%20AND%20humans[mesh]%20AND%20review[publication%20type]" ref="ncbi_uid=&discoId=gtr_reviews&linkpos=2&linkpostotal=2" target="_blank">Reviews in PubMed</a>
|
||
</li>
|
||
</ul>
|
||
</div>
|
||
</div>
|
||
|
||
<!-- MedGen supplemental column ends here -->
|
||
<div class="portlet brieflink">
|
||
<div class="portlet_head">
|
||
<div class="portlet_title">
|
||
<h3>Related information</h3>
|
||
</div>
|
||
<a name="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_SingleItemSuplCluster.MedGenDiscoveryDbLinks.Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="discovery_db_links" id="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_SingleItemSuplCluster.MedGenDiscoveryDbLinks.Shutter"></a>
|
||
</div>
|
||
<div class="portlet_content DiscoveryDbLinks">
|
||
<ul>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/clinvar?LinkName=medgen_clinvar&from_uid=86954" ref="log$=recordlinks">ClinVar</a>
|
||
<div class="brieflinkpop offscreen_noflow">Related medical variations</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/gtr/tests?term=C0079744[DISCUI]" ref="log$=recordlinks">GTR</a>
|
||
<div class="brieflinkpop offscreen_noflow">Related information in GTR</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/gtr/tests?term=C0079744[DISCUI]&test_type=Clinical" ref="log$=recordlinks">GTR(Clinical)</a>
|
||
<div class="brieflinkpop offscreen_noflow">Clinical tests in GTR</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/mesh?LinkName=medgen_mesh&from_uid=86954" ref="log$=recordlinks">MeSH</a>
|
||
<div class="brieflinkpop offscreen_noflow">Related Medical Subject Headings</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/pmc?LinkName=medgen_pmc&from_uid=86954" ref="log$=recordlinks">PMC Articles</a>
|
||
<div class="brieflinkpop offscreen_noflow">Related information in PubMed Central Links</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/pubmed?LinkName=medgen_pubmed&from_uid=86954" ref="log$=recordlinks">PubMed</a>
|
||
<div class="brieflinkpop offscreen_noflow">Related literature resources in PubMed</div>
|
||
</li>
|
||
</ul>
|
||
</div>
|
||
</div>
|
||
|
||
|
||
<div class="portlet">
|
||
<div class="portlet_head">
|
||
<div class="portlet_title">
|
||
<h3>Recent activity</h3>
|
||
</div>
|
||
<a name="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.HistoryDisplay.Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="recent_activity" id="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.HistoryDisplay.Shutter"></a>
|
||
</div>
|
||
<div class="portlet_content">
|
||
<div id="HTDisplay" class="">
|
||
<input name="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.HistoryDisplay.Cmd" sid="1" type="hidden" />
|
||
<div class="action">
|
||
<a name="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.HistoryDisplay.ClearHistory" sid="1" realname="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.HistoryDisplay.ClearHistory" cmd="ClearHT" href="?cmd=ClearHT&" onclick="return false;" id="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.HistoryDisplay.ClearHistory">
|
||
Clear
|
||
</a>
|
||
<a name="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.HistoryDisplay.HistoryToggle" sid="1" realname="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.HistoryDisplay.HistoryToggle" class="HTOn" cmd="HTOff" href="?cmd=HTOff&" onclick="return false;" id="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.HistoryDisplay.HistoryToggle">
|
||
Turn Off
|
||
</a>
|
||
<a name="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.HistoryDisplay.HistoryToggle" sid="2" realname="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.HistoryDisplay.HistoryToggle" class="HTOff" cmd="HTOn" href="?cmd=HTOn&" onclick="return false;" id="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.HistoryDisplay.HistoryToggle">
|
||
Turn On
|
||
</a>
|
||
</div>
|
||
<ul id="activity">
|
||
<li class="ra_rcd ralinkpopper two_line">
|
||
<a class="htb ralinkpopperctrl" ref="log$=activity&linkpos=1" href="/portal/utils/pageresolver.fcgi?recordid=67d190d2f4a390645efbd504">Malignant lymphoma, large B-cell, diffuse</a>
|
||
<div class="ralinkpop offscreen_noflow">Malignant lymphoma, large B-cell, diffuse<div class="brieflinkpopdesc"></div></div>
|
||
<div class="tertiary">MedGen</div>
|
||
</li>
|
||
<li class="ra_qry two_line">
|
||
<a class="htb" ref="log$=activity&linkpos=2" href="/portal/utils/pageresolver.fcgi?recordid=67d190d0b15b832ebcd77905">C0079744[conceptid] <span class="number">(1)</span></a>
|
||
<div class="tertiary">MedGen</div>
|
||
</li>
|
||
<li class="ra_qry ralinkpopper two_line">
|
||
<a class="htb ralinkpopperctrl" ref="log$=activity&linkpos=3" href="/portal/utils/pageresolver.fcgi?recordid=67d190cfa68b6b5afc3e9d04">"Department Of Pathology & Laboratory Medicine, University Of Pen... <span class="number">(1)</span></a>
|
||
<div class="ralinkpop offscreen_noflow">"Department Of Pathology & Laboratory Medicine, University Of Pennsylvania"[submitter] AND "TP53"[gene]<div class="brieflinkpopdesc">Search</div></div>
|
||
<div class="tertiary">ClinVar</div>
|
||
</li>
|
||
<li class="ra_qry ralinkpopper two_line">
|
||
<a class="htb ralinkpopperctrl" ref="log$=activity&linkpos=4" href="/portal/utils/pageresolver.fcgi?recordid=67d190cd84f3725e59fa1d8e">"Department Of Pathology & Laboratory Medicine, University Of Pen... <span class="number">(1)</span></a>
|
||
<div class="ralinkpop offscreen_noflow">"Department Of Pathology & Laboratory Medicine, University Of Pennsylvania"[submitter] AND "STAT3"[gene]<div class="brieflinkpopdesc">Search</div></div>
|
||
<div class="tertiary">ClinVar</div>
|
||
</li>
|
||
<li class="ra_qry ralinkpopper two_line">
|
||
<a class="htb ralinkpopperctrl" ref="log$=activity&linkpos=5" href="/portal/utils/pageresolver.fcgi?recordid=67d190ccb15b832ebcd7624f">"Department Of Pathology & Laboratory Medicine, University Of Pen... <span class="number">(1)</span></a>
|
||
<div class="ralinkpop offscreen_noflow">"Department Of Pathology & Laboratory Medicine, University Of Pennsylvania"[submitter] AND "SOCS1"[gene]<div class="brieflinkpopdesc">Search</div></div>
|
||
<div class="tertiary">ClinVar</div>
|
||
</li>
|
||
</ul>
|
||
<p class="HTOn">Your browsing activity is empty.</p>
|
||
<p class="HTOff">Activity recording is turned off.</p>
|
||
<p id="turnOn" class="HTOff">
|
||
<a name="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.HistoryDisplay.HistoryOn" sid="1" realname="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.HistoryDisplay.HistoryOn" cmd="HTOn" href="?cmd=HTOn&" onclick="return false;" id="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.HistoryDisplay.HistoryOn">Turn recording back on</a>
|
||
</p>
|
||
<a class="seemore" href="/sites/myncbi/recentactivity">See more...</a>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
|
||
</div>
|
||
</div>
|
||
|
||
<div id="NCBIFooter_dynamic">
|
||
<!--<component id="NCBIBreadcrumbs"/>
|
||
<component id="NCBIHelpDesk"/>-->
|
||
<noscript><img alt="" src="/stat?jsdisabled=true&ncbi_app=entrez&ncbi_db=medgen&ncbi_pdid=FullReport&ncbi_phid=CE8DD8927D18939100000000009F007A" /></noscript>
|
||
</div>
|
||
|
||
<div xmlns="http://www.w3.org/1999/xhtml" class="footer" id="footer" xml:base="http://127.0.0.1/sites/static/header_footer/">
|
||
<section class="icon-section">
|
||
<div id="icon-section-header" class="icon-section_header">Follow NCBI</div>
|
||
<div class="grid-container container">
|
||
<div class="icon-section_container">
|
||
<a class="footer-icon" id="footer_twitter" href="https://twitter.com/ncbi" aria-label="Twitter">
|
||
<svg xmlns="http://www.w3.org/2000/svg" width="40" height="40" viewBox="0 0 40 40" fill="none">
|
||
<title>Twitter</title>
|
||
<g id="twitterx1008">
|
||
<path id="path1008" d="M6.06736 7L16.8778 20.8991L6.00001 32.2H10.2L18.6 23.1L25.668 32.2H34L22.8 17.5L31.9 7H28.4L20.7 15.4L14.401 7H6.06898H6.06736ZM9.66753 8.73423H12.9327L29.7327 30.4658H26.5697L9.66753 8.73423Z" fill="#5B616B"></path>
|
||
</g>
|
||
</svg>
|
||
</a>
|
||
<a class="footer-icon" id="footer_facebook" href="https://www.facebook.com/ncbi.nlm" aria-label="Facebook"><svg xmlns="http://www.w3.org/2000/svg" data-name="Layer 1" viewBox="0 0 300 300">
|
||
<title>Facebook</title>
|
||
<path class="cls-11" d="M210.5,115.12H171.74V97.82c0-8.14,5.39-10,9.19-10h27.14V52l-39.32-.12c-35.66,0-42.42,26.68-42.42,43.77v19.48H99.09v36.32h27.24v109h45.41v-109h35Z">
|
||
</path>
|
||
</svg></a>
|
||
<a class="footer-icon" id="footer_linkedin" href="https://www.linkedin.com/company/ncbinlm" aria-label="LinkedIn"><svg xmlns="http://www.w3.org/2000/svg" data-name="Layer 1" viewBox="0 0 300 300">
|
||
<title>LinkedIn</title>
|
||
<path class="cls-11" d="M101.64,243.37H57.79v-114h43.85Zm-22-131.54h-.26c-13.25,0-21.82-10.36-21.82-21.76,0-11.65,8.84-21.15,22.33-21.15S101.7,78.72,102,90.38C102,101.77,93.4,111.83,79.63,111.83Zm100.93,52.61A17.54,17.54,0,0,0,163,182v61.39H119.18s.51-105.23,0-114H163v13a54.33,54.33,0,0,1,34.54-12.66c26,0,44.39,18.8,44.39,55.29v58.35H198.1V182A17.54,17.54,0,0,0,180.56,164.44Z">
|
||
</path>
|
||
</svg></a>
|
||
<a class="footer-icon" id="footer_github" href="https://github.com/ncbi" aria-label="GitHub"><svg xmlns="http://www.w3.org/2000/svg" data-name="Layer 1" viewBox="0 0 300 300">
|
||
<defs>
|
||
<style>
|
||
.cls-11,
|
||
.cls-12 {
|
||
fill: #737373;
|
||
}
|
||
|
||
.cls-11 {
|
||
fill-rule: evenodd;
|
||
}
|
||
</style>
|
||
</defs>
|
||
<title>GitHub</title>
|
||
<path class="cls-11" d="M151.36,47.28a105.76,105.76,0,0,0-33.43,206.1c5.28,1,7.22-2.3,7.22-5.09,0-2.52-.09-10.85-.14-19.69-29.42,6.4-35.63-12.48-35.63-12.48-4.81-12.22-11.74-15.47-11.74-15.47-9.59-6.56.73-6.43.73-6.43,10.61.75,16.21,10.9,16.21,10.9,9.43,16.17,24.73,11.49,30.77,8.79,1-6.83,3.69-11.5,6.71-14.14C108.57,197.1,83.88,188,83.88,147.51a40.92,40.92,0,0,1,10.9-28.39c-1.1-2.66-4.72-13.42,1-28,0,0,8.88-2.84,29.09,10.84a100.26,100.26,0,0,1,53,0C198,88.3,206.9,91.14,206.9,91.14c5.76,14.56,2.14,25.32,1,28a40.87,40.87,0,0,1,10.89,28.39c0,40.62-24.74,49.56-48.29,52.18,3.79,3.28,7.17,9.71,7.17,19.58,0,14.15-.12,25.54-.12,29,0,2.82,1.9,6.11,7.26,5.07A105.76,105.76,0,0,0,151.36,47.28Z">
|
||
</path>
|
||
<path class="cls-12" d="M85.66,199.12c-.23.52-1.06.68-1.81.32s-1.2-1.06-.95-1.59,1.06-.69,1.82-.33,1.21,1.07.94,1.6Zm-1.3-1">
|
||
</path>
|
||
<path class="cls-12" d="M90,203.89c-.51.47-1.49.25-2.16-.49a1.61,1.61,0,0,1-.31-2.19c.52-.47,1.47-.25,2.17.49s.82,1.72.3,2.19Zm-1-1.08">
|
||
</path>
|
||
<path class="cls-12" d="M94.12,210c-.65.46-1.71,0-2.37-.91s-.64-2.07,0-2.52,1.7,0,2.36.89.65,2.08,0,2.54Zm0,0"></path>
|
||
<path class="cls-12" d="M99.83,215.87c-.58.64-1.82.47-2.72-.41s-1.18-2.06-.6-2.7,1.83-.46,2.74.41,1.2,2.07.58,2.7Zm0,0">
|
||
</path>
|
||
<path class="cls-12" d="M107.71,219.29c-.26.82-1.45,1.2-2.64.85s-2-1.34-1.74-2.17,1.44-1.23,2.65-.85,2,1.32,1.73,2.17Zm0,0">
|
||
</path>
|
||
<path class="cls-12" d="M116.36,219.92c0,.87-1,1.59-2.24,1.61s-2.29-.68-2.3-1.54,1-1.59,2.26-1.61,2.28.67,2.28,1.54Zm0,0">
|
||
</path>
|
||
<path class="cls-12" d="M124.42,218.55c.15.85-.73,1.72-2,1.95s-2.37-.3-2.52-1.14.73-1.75,2-2,2.37.29,2.53,1.16Zm0,0"></path>
|
||
</svg></a>
|
||
<a class="footer-icon" id="footer_blog" href="https://ncbiinsights.ncbi.nlm.nih.gov/" aria-label="Blog">
|
||
<svg xmlns="http://www.w3.org/2000/svg" id="Layer_1" data-name="Layer 1" viewBox="0 0 40 40">
|
||
<defs><style>.cls-1{fill:#737373;}</style></defs>
|
||
<title>NCBI Insights Blog</title>
|
||
<path class="cls-1" d="M14,30a4,4,0,1,1-4-4,4,4,0,0,1,4,4Zm11,3A19,19,0,0,0,7.05,15a1,1,0,0,0-1,1v3a1,1,0,0,0,.93,1A14,14,0,0,1,20,33.07,1,1,0,0,0,21,34h3a1,1,0,0,0,1-1Zm9,0A28,28,0,0,0,7,6,1,1,0,0,0,6,7v3a1,1,0,0,0,1,1A23,23,0,0,1,29,33a1,1,0,0,0,1,1h3A1,1,0,0,0,34,33Z"></path>
|
||
</svg>
|
||
</a>
|
||
</div>
|
||
</div>
|
||
</section>
|
||
|
||
<section class="container-fluid bg-primary">
|
||
<div class="container pt-5">
|
||
<div class="row mt-3">
|
||
<div class="col-lg-3 col-12">
|
||
<p><a class="text-white" href="https://www.nlm.nih.gov/socialmedia/index.html">Connect with NLM</a></p>
|
||
<ul class="list-inline social_media">
|
||
<li class="list-inline-item"><a href="https://twitter.com/NLM_NIH" aria-label="Twitter" target="_blank" rel="noopener noreferrer">
|
||
<svg xmlns="http://www.w3.org/2000/svg" width="35" height="35" viewBox="0 0 36 35" fill="none">
|
||
<title>Twitter</title>
|
||
<g id="twitterx1009" clip-path="url(#clip0_65276_3946)">
|
||
<path id="Vector_Twitter" d="M17.5006 34.6565C26.9761 34.6565 34.6575 26.9751 34.6575 17.4996C34.6575 8.02416 26.9761 0.342773 17.5006 0.342773C8.02514 0.342773 0.34375 8.02416 0.34375 17.4996C0.34375 26.9751 8.02514 34.6565 17.5006 34.6565Z" fill="#205493" stroke="white" stroke-width="1.0" stroke-miterlimit="10"></path>
|
||
<path id="path1009" d="M8.54811 8.5L16.2698 18.4279L8.50001 26.5H11.5L17.5 20L22.5486 26.5H28.5L20.5 16L27 8.5H24.5L19 14.5L14.5007 8.5H8.54927H8.54811ZM11.1197 9.73873H13.4519L25.4519 25.2613H23.1926L11.1197 9.73873Z" fill="white"></path>
|
||
</g>
|
||
<defs>
|
||
<clipPath id="clip0_65276_3946">
|
||
<rect width="35" height="35" fill="white"></rect>
|
||
</clipPath>
|
||
</defs>
|
||
</svg>
|
||
</a></li>
|
||
<li class="list-inline-item"><a href="https://www.facebook.com/nationallibraryofmedicine" aria-label="Facebook" rel="noopener noreferrer" target="_blank">
|
||
<svg xmlns="http://www.w3.org/2000/svg" width="35" height="35" viewBox="0 0 36 35" fill="none">
|
||
<title>Facebook</title>
|
||
<g id="Facebook" clip-path="url(#clip0_1717_1086)">
|
||
<path id="Vector_Facebook" d="M15.1147 29.1371C15.1147 29.0822 15.1147 29.0296 15.1147 28.9747V18.9414H11.8183C11.6719 18.9414 11.6719 18.9414 11.6719 18.8018C11.6719 17.5642 11.6719 16.3289 11.6719 15.0937C11.6719 14.9793 11.7062 14.9518 11.816 14.9518C12.8683 14.9518 13.9206 14.9518 14.9751 14.9518H15.1215V14.8329C15.1215 13.8057 15.1215 12.774 15.1215 11.7492C15.1274 10.9262 15.3148 10.1146 15.6706 9.37241C16.1301 8.38271 16.9475 7.60378 17.9582 7.19235C18.6492 6.90525 19.3923 6.76428 20.1405 6.7783C21.0029 6.79202 21.8653 6.83091 22.7278 6.86065C22.8879 6.86065 23.048 6.89496 23.2082 6.90182C23.2974 6.90182 23.3271 6.94071 23.3271 7.02993C23.3271 7.54235 23.3271 8.05477 23.3271 8.5649C23.3271 9.16882 23.3271 9.77274 23.3271 10.3767C23.3271 10.4819 23.2974 10.5139 23.1921 10.5116C22.5379 10.5116 21.8814 10.5116 21.2271 10.5116C20.9287 10.5184 20.6316 10.5528 20.3395 10.6146C20.0822 10.6619 19.8463 10.7891 19.6653 10.9779C19.4842 11.1668 19.3672 11.4078 19.3307 11.6669C19.2857 11.893 19.2612 12.1226 19.2575 12.3531C19.2575 13.1904 19.2575 14.0299 19.2575 14.8695C19.2575 14.8946 19.2575 14.9198 19.2575 14.9564H23.0229C23.1807 14.9564 23.183 14.9564 23.1624 15.1074C23.0778 15.7662 22.9885 16.425 22.9039 17.0816C22.8322 17.6321 22.7636 18.1827 22.698 18.7332C22.6729 18.9437 22.6797 18.9437 22.4693 18.9437H19.2644V28.8992C19.2644 28.9793 19.2644 29.0593 19.2644 29.1394L15.1147 29.1371Z" fill="white"></path>
|
||
<path id="Vector_2_Facebook" d="M17.5006 34.657C26.9761 34.657 34.6575 26.9756 34.6575 17.5001C34.6575 8.02465 26.9761 0.343262 17.5006 0.343262C8.02514 0.343262 0.34375 8.02465 0.34375 17.5001C0.34375 26.9756 8.02514 34.657 17.5006 34.657Z" stroke="white" stroke-width="1.0" stroke-miterlimit="10"></path>
|
||
</g>
|
||
<defs>
|
||
<clipPath id="clip0_1717_1086">
|
||
<rect width="35" height="35" fill="white"></rect>
|
||
</clipPath>
|
||
</defs>
|
||
</svg>
|
||
</a></li>
|
||
<li class="list-inline-item"><a href="https://www.youtube.com/user/NLMNIH" aria-label="Youtube" target="_blank" rel="noopener noreferrer">
|
||
<svg xmlns="http://www.w3.org/2000/svg" width="35" height="35" viewBox="0 0 36 35" fill="none">
|
||
<title>Youtube</title>
|
||
<g id="YouTube" clip-path="url(#clip0_1717_1101)">
|
||
<path id="Vector_Youtube" d="M26.2571 11.4791C25.9025 11.1589 25.5709 10.9576 24.228 10.834C22.5512 10.6785 20.2797 10.6556 18.564 10.6533H16.4365C14.7208 10.6533 12.4493 10.6785 10.7725 10.834C9.43196 10.9576 9.09798 11.1589 8.7434 11.4791C7.81464 12.321 7.6202 14.6268 7.59961 16.8938C7.59961 17.3178 7.59961 17.741 7.59961 18.1635C7.62706 20.4121 7.82837 22.686 8.7434 23.521C9.09798 23.8412 9.42967 24.0425 10.7725 24.1661C12.4493 24.3216 14.7208 24.3445 16.4365 24.3468H18.564C20.2797 24.3468 22.5512 24.3216 24.228 24.1661C25.5686 24.0425 25.9025 23.8412 26.2571 23.521C27.1722 22.6929 27.3735 20.451 27.4009 18.2206C27.4009 17.7402 27.4009 17.2599 27.4009 16.7795C27.3735 14.5491 27.1699 12.3072 26.2571 11.4791ZM15.5604 20.5311V14.652L20.561 17.5001L15.5604 20.5311Z" fill="white"></path>
|
||
<path id="Vector_2_Youtube" d="M17.5006 34.657C26.9761 34.657 34.6575 26.9756 34.6575 17.5001C34.6575 8.02465 26.9761 0.343262 17.5006 0.343262C8.02514 0.343262 0.34375 8.02465 0.34375 17.5001C0.34375 26.9756 8.02514 34.657 17.5006 34.657Z" stroke="white" stroke-width="1.0" stroke-miterlimit="10"></path>
|
||
</g>
|
||
<defs>
|
||
<clipPath id="clip0_1717_1101">
|
||
<rect width="35" height="35" fill="white"></rect>
|
||
</clipPath>
|
||
</defs>
|
||
</svg>
|
||
</a></li>
|
||
</ul>
|
||
</div>
|
||
<div class="col-lg-3 col-12">
|
||
<p class="address_footer text-white">National Library of Medicine<br />
|
||
<a href="https://www.google.com/maps/place/8600+Rockville+Pike,+Bethesda,+MD+20894/@38.9959508,-77.101021,17z/data=!3m1!4b1!4m5!3m4!1s0x89b7c95e25765ddb:0x19156f88b27635b8!8m2!3d38.9959508!4d-77.0988323" class="text-white" target="_blank" rel="noopener noreferrer">8600 Rockville Pike<br />
|
||
Bethesda, MD 20894</a></p>
|
||
</div>
|
||
<div class="col-lg-3 col-12 centered-lg">
|
||
<p><a href="https://www.nlm.nih.gov/web_policies.html" class="text-white">Web Policies</a><br />
|
||
<a href="https://www.nih.gov/institutes-nih/nih-office-director/office-communications-public-liaison/freedom-information-act-office" class="text-white">FOIA</a><br />
|
||
<a href="https://www.hhs.gov/vulnerability-disclosure-policy/index.html" class="text-white" id="vdp">HHS Vulnerability Disclosure</a></p>
|
||
</div>
|
||
<div class="col-lg-3 col-12 centered-lg">
|
||
<p><a class="supportLink text-white" href="https://support.nlm.nih.gov/">Help</a><br />
|
||
<a href="https://www.nlm.nih.gov/accessibility.html" class="text-white">Accessibility</a><br />
|
||
<a href="https://www.nlm.nih.gov/careers/careers.html" class="text-white">Careers</a></p>
|
||
</div>
|
||
</div>
|
||
<div class="row">
|
||
<div class="col-lg-12 centered-lg">
|
||
<nav class="bottom-links">
|
||
<ul class="mt-3">
|
||
<li>
|
||
<a class="text-white" href="//www.nlm.nih.gov/">NLM</a>
|
||
</li>
|
||
<li>
|
||
<a class="text-white" href="https://www.nih.gov/">NIH</a>
|
||
</li>
|
||
<li>
|
||
<a class="text-white" href="https://www.hhs.gov/">HHS</a>
|
||
</li>
|
||
<li>
|
||
<a class="text-white" href="https://www.usa.gov/">USA.gov</a>
|
||
</li>
|
||
</ul>
|
||
</nav>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
</section>
|
||
<script type="text/javascript" src="/portal/portal3rc.fcgi/rlib/js/InstrumentOmnitureBaseJS/InstrumentNCBIConfigJS/InstrumentNCBIBaseJS/InstrumentPageStarterJS.js?v=1"> </script>
|
||
<script type="text/javascript" src="/portal/portal3rc.fcgi/static/js/hfjs2.js"> </script>
|
||
</div>
|
||
|
||
</div>
|
||
<div><input name="EntrezSystem2.PEntrez.DbConnector.Db" sid="1" type="hidden" value="medgen" /><input name="EntrezSystem2.PEntrez.DbConnector.LastDb" sid="1" type="hidden" value="medgen" /><input name="EntrezSystem2.PEntrez.DbConnector.Term" sid="1" type="hidden" value="C0079744[conceptid]" /><input name="EntrezSystem2.PEntrez.DbConnector.LastTabCmd" sid="1" type="hidden" value="" /><input name="EntrezSystem2.PEntrez.DbConnector.LastQueryKey" sid="1" type="hidden" value="22921" /><input name="EntrezSystem2.PEntrez.DbConnector.IdsFromResult" sid="1" type="hidden" value="" /><input name="EntrezSystem2.PEntrez.DbConnector.LastIdsFromResult" sid="1" type="hidden" value="" /><input name="EntrezSystem2.PEntrez.DbConnector.LinkName" sid="1" type="hidden" /><input name="EntrezSystem2.PEntrez.DbConnector.LinkReadableName" sid="1" type="hidden" /><input name="EntrezSystem2.PEntrez.DbConnector.LinkSrcDb" sid="1" type="hidden" /><input name="EntrezSystem2.PEntrez.DbConnector.Cmd" sid="1" type="hidden" /><input name="EntrezSystem2.PEntrez.DbConnector.TabCmd" sid="1" type="hidden" /><input name="EntrezSystem2.PEntrez.DbConnector.QueryKey" sid="1" type="hidden" /></div>
|
||
<input type="hidden" name="p$a" id="p$a" /><input type="hidden" name="p$l" id="p$l" value="EntrezSystem2" /><input type="hidden" name="p$st" id="p$st" value="medgen" /><input name="SessionId" id="SessionId" value="CE8B5AF87C7FFCB1_0191SID" disabled="disabled" type="hidden" /><input name="Snapshot" id="Snapshot" value="/projects/Phenotype/MedGen/MedGen@6.14" disabled="disabled" type="hidden" /></form>
|
||
</div>
|
||
</div>
|
||
|
||
|
||
<!-- CE8B5AF87C7FFCB1_0191SID /projects/Phenotype/MedGen/MedGen@6.14 portal106 v4.1.r689238 Tue, Oct 22 2024 16:10:51 -->
|
||
<span id="portal-csrf-token" style="display:none" data-token="CE8B5AF87C7FFCB1_0191SID"></span>
|
||
|
||
|
||
<script type='text/javascript' src='/portal/js/portal.js'></script><script type="text/javascript" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/js/4221766/3812534/4212053/3812535/3781605/4186313/2499590/3758627/4078478/3908752/3423/4018706/3891418/4212356/4078480/4078479/4025341/4076482/31971/35962/2733373/33966/3397055/4001808.js" snapshot="medgen"></script></body>
|
||
</html> |