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<meta name="keywords" content="C0032463, acquired polycythemia vera, acquired primary erythrocytosis, disease, osler-vaquez, erythremia, erythremias, jak2, neoplastic process, osler vaquez disease, osler-vaquez disease, osler-vaquez syndrome, polycythaemia rubra vera, polycythemia ruba vera, polycythemia ruba veras, polycythemia rubra vera, polycythemia rubra veras, polycythemia vera, polycythemia vera (clinical), polycythemia vera, somatic, polycythemia, primary, polycythemias, primary, ppp - primary proliferative polycythemia, primary polycythemia, primary polycythemias, primary proliferative polycythemia, proliferative polycythaemia, proliferative polycythemia, prv, prv - polycythemia rubra vera, pv, ruba vera, polycythemia, ruba veras, polycythemia, suspected polycythemia vera, vaquez disease, vaquez's disease, vera, polycythemia ruba, vera, polycythemia rubra, veras, polycythemia ruba, veras, polycythemia rubra, autosomal dominant, autosomal recessive, birth defects, chromosomal disease, chromosome, clinical features, clinical findings, clinical genetics, clinical recommendations, clinvar, congenital chromosomal disease, consumer genetic resources, cytogenetic location, disease characteristics, disease definitions, disease descriptions, disease ontology, disease synonyms, disease vocabulary, dysmorphology, entrez, familial disease, gene, gene-disease relationship, genereviews, genetic disease, genetic disorder, genetic terminology, genetic testing registry, genetics home reference, genomic disease, gtr, hereditary disease, heritable disease, hpo, human phenotype ontology, inherited disease, management guidelines, maternal inheritance, medgen, medical genetics, medical subject headings, mesh, mitochondrial inheritance, mode of inheritance, national center for biotechnology information, national institutes of health, national library of medicine, ncbi, nih, nlm, omim, ordo, orphanet, paternal inheritance, phenome, position statements, professional practice guidelines, rare disease, reference sequence, refseq, snomed ct, syndrome, undiagnosed diseases, x-linked recessive" /><meta name="description" content="Polycythemia vera (PV), the most common form of primary polycythemia, is caused by somatic mutation in a single hematopoietic stem cell leading to clonal hematopoiesis. PV is a myeloproliferative disorder characterized predominantly by erythroid hyperplasia, but also by myeloid leukocytosis, thrombocytosis, and splenomegaly. Familial cases of PV are very rare and usually manifest in elderly patients (Cario, 2005). PV is distinct from the familial erythrocytoses (see, e.g., ECYT1, 133100), which are caused by inherited mutations resulting in hypersensitivity of erythroid progenitors to hormonal influences or increased levels of circulating hormones, namely erythropoietin (EPO; 133170) (Prchal, 2005)." /><meta name="robots" content="index,nofollow,noarchive" />
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<!--
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UID=45996
|
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ConceptID=C0032463
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-->
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<!--imgCountBooks = 0--><h1 class="medgenTitle"><div class="MedGenTitleText">Acquired polycythemia vera<span class="h1sub">(PRV; PV)</span></div></h1><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>45996</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information."><span class="highlight" style="background-color:">C0032463</span></a></dd><dt><span class="dotprefix"> •</span></dt><dd>Neoplastic Process</dd></dl></div></div><table class="medgenTable"><tbody><tr><td>Synonyms:</td>
|
||
<td>POLYCYTHEMIA RUBRA VERA; Polycythemia vera; Polycythemia vera, somatic; Suspected polycythemia vera</td></tr>
|
||
<tr><td><span class="bold">SNOMED CT: </span></td>
|
||
<td>Vaquez's disease (109992005); Osler-Vaquez syndrome (109992005); Polycythemia vera (clinical) (109992005); Proliferative polycythemia (128841001); Polycythemia rubra vera (128841001); Polycythemia vera (128841001); Polycythemia rubra vera (109992005); Polycythemia vera (109992005); PPP - Primary proliferative polycythemia (109992005); Primary proliferative polycythemia (109992005); PRV - Polycythemia rubra vera (109992005)</td></tr>
|
||
<tr><td>Modes of inheritance:</td>
|
||
<td>
|
||
<div class="divPopper rprt" id="moi_988794"><div><strong>Not genetically inherited</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>988794</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier assigned by MedGen (starting with CN) for terms that cannot be identified in NLM's Unified Medical Language system (UMLS) Click for more information.">CN307044</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Finding</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Source: Orphanet</div>
|
||
<div class="spaceAbove">clinical entity without genetic inheritance.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/988794">This record</a></div></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#moi_988794" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Not genetically inherited</a><span> (Orphanet)</span></div></td></tr>
|
||
<tr><td colspan="2" class="small"> </td></tr><tr><td><a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#target-gene-loc">Gene (location):<img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a><div class="display-none" id="target-gene-loc">
|
||
Gene(s) directly associated with<br />
|
||
this condition or phenotype.</div></td>
|
||
<td><a target="_blank" title="JAK2 - ID: 3717 - NCBI Gene" href="/gene/3717" class="medgenPMinfo">JAK2</a> (9p24.1)</td></tr>
|
||
<tr><td colspan="2" class="small"> </td></tr><tr><td>Monarch Initiative:</td>
|
||
<td><a href="https://monarchinitiative.org/disease/MONDO:0009891" target="_blank">MONDO:0009891</a></td></tr>
|
||
<tr><td>OMIM<span class="superscript">®</span>:</td>
|
||
<td><a href="https://omim.org/entry/263300" target="_blank">263300</a></td></tr>
|
||
<tr><td>Orphanet:</td>
|
||
<td><a target="_blank" title="Orphanet: The portal for rare diseases and orphan drugs" href="http://www.orpha.net/consor/cgi-bin/OC_Exp.php?lng=EN&Expert=729">ORPHA729</a></td></tr></tbody></table></div><div class="rprt-body jig-ncbiinpagenav" data-jigconfig="smoothScroll: false, gotoTopLink: true, gotoTopLinkText: '', gotoTopLinkAttrs: {'title': 'Go to the top of the page'},allHeadingLevels: ['h1'], topOfPageTOC: true, tocId: 'my-toc'"><div id="rprt-tabs-1" class="rprt-tab"><div id="tb-termsProp-1"><div class="leftCol mgCol"><div>
|
||
<div class="portlet mgSection" id="ID_100">
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||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Definition">Definition</h1><a sid="100" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln">Polycythemia vera (PV), the most common form of primary polycythemia, is caused by somatic mutation in a single hematopoietic stem cell leading to clonal hematopoiesis. PV is a myeloproliferative disorder characterized predominantly by erythroid hyperplasia, but also by myeloid leukocytosis, thrombocytosis, and splenomegaly. Familial cases of PV are very rare and usually manifest in elderly patients (Cario, 2005). PV is distinct from the familial erythrocytoses (see, e.g., ECYT1, 133100), which are caused by inherited mutations resulting in hypersensitivity of erythroid progenitors to hormonal influences or increased levels of circulating hormones, namely erythropoietin (EPO; 133170) (Prchal, 2005). [from <a title="Online Mendelian Inheritance in Man" href="http://www.omim.org" class="defSource" target="_blank">OMIM</a>]</div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_117">
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||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Additional_description">Additional description</h1><a sid="117" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><div class="mgSection"><strong>From MedlinePlus Genetics</strong><br />Polycythemia vera is a condition characterized by an increased number of red blood cells in the bloodstream. Affected individuals may also have excess white blood cells and blood clotting cells called platelets. These extra cells and platelets cause the blood to be thicker than normal. As a result, abnormal blood clots are more likely to form and block the flow of blood through arteries and veins. Individuals with polycythemia vera have an increased risk of deep vein thrombosis (DVT), a type of blood clot that occurs in the deep veins of the arms or legs. If a DVT travels through the bloodstream and lodges in the lungs, it can cause a life-threatening clot known as a pulmonary embolism (PE). Affected individuals also have an increased risk of heart attack and stroke caused by blood clots in the heart and brain.<br /><br />Polycythemia vera typically develops in adulthood, around age 60, although in rare cases it occurs in children and young adults. This condition may not cause any symptoms in its early stages. Some people with polycythemia vera experience headaches, dizziness, ringing in the ears (tinnitus), impaired vision, or itchy skin. Affected individuals frequently have reddened skin because of the extra red blood cells. Other complications of polycythemia vera include an enlarged spleen (splenomegaly), stomach ulcers, gout (a form of arthritis caused by a buildup of uric acid in the joints), heart disease, and cancer of blood-forming cells (leukemia). <a target="_blank" href="https://medlineplus.gov/genetics/condition/polycythemia-vera">https://medlineplus.gov/genetics/condition/polycythemia-vera</a></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_102">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Clinical_features">Clinical features</h1><a sid="102" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln clinfeat"><strong>From HPO</strong><br />
|
||
<div class="divPopper rprt" id="clin_163632"><div><strong>Budd-Chiari syndrome</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>163632</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0856761</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Budd-Chiari syndrome (BDCHS) is defined as thrombosis of one or more of the large hepatic veins, the inferior vena cava, or both. Patients present with a classic clinical triad of abdominal pain, hepatomegaly, and ascites, typically associated with nonspecific elevations of liver enzymes. The disorder may be acute, subacute, or chronic. Edema of the legs may be present (summary by Chung et al., 2006).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/163632">Feature record</a> | <a href="/medgen?term=%22Budd-Chiari%20syndrome%22%5BClinical%20Features%5D%20OR%20163632%5Buid%5D">Search on this feature</a></div></div>
|
||
<div class="divPopper rprt" id="clin_182975"><div><strong>Cerebral ischemia</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>182975</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0917798</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Pathologic Function</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Restriction of arterial blood supply to the brain associated with insufficient oxygenation to support the metabolic requirements of the tissue.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/182975">Feature record</a> | <a href="/medgen?term=%22Cerebral%20ischemia%22%5BClinical%20Features%5D%20OR%20182975%5Buid%5D">Search on this feature</a></div></div>
|
||
<div class="divPopper rprt" id="clin_423648"><div><strong>Cerebral hemorrhage</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>423648</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C2937358</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Pathologic Function</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Hemorrhage into the parenchyma of the brain.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/423648">Feature record</a> | <a href="/medgen?term=%22Cerebral%20hemorrhage%22%5BClinical%20Features%5D%20OR%20423648%5Buid%5D">Search on this feature</a></div></div>
|
||
<div class="divPopper rprt" id="clin_8971"><div><strong>Gastrointestinal hemorrhage</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>8971</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0017181</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Pathologic Function</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Hemorrhage affecting the gastrointestinal tract.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/8971">Feature record</a> | <a href="/medgen?term=%22Gastrointestinal%20hemorrhage%22%5BClinical%20Features%5D%20OR%208971%5Buid%5D">Search on this feature</a></div></div>
|
||
<div class="divPopper rprt" id="clin_52737"><div><strong>Thrombocytopenia</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>52737</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0040034</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">A reduction in the number of circulating thrombocytes.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/52737">Feature record</a> | <a href="/medgen?term=%22Thrombocytopenia%22%5BClinical%20Features%5D%20OR%2052737%5Buid%5D">Search on this feature</a></div></div>
|
||
<div class="divPopper rprt" id="clin_21532"><div><strong>Thromboembolism</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>21532</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0040038</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Pathologic Function</dd></dl></div></div></div>
|
||
<div class="spaceAbove">The formation of a blood clot inside a blood vessel that subsequently travels through the blood stream from the site where it formed to another location in the body, generally leading to vascular occlusion at the distant site.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/21532">Feature record</a> | <a href="/medgen?term=%22Thromboembolism%22%5BClinical%20Features%5D%20OR%2021532%5Buid%5D">Search on this feature</a></div></div>
|
||
<div class="divPopper rprt" id="clin_68692"><div><strong>Increased hematocrit</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>68692</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0239935</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Finding</dd></dl></div></div></div>
|
||
<div class="spaceAbove">An elevation above the normal ratio of the volume of red blood cells to the total volume of blood.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/68692">Feature record</a> | <a href="/medgen?term=%22Increased%20hematocrit%22%5BClinical%20Features%5D%20OR%2068692%5Buid%5D">Search on this feature</a></div></div>
|
||
<div class="divPopper rprt" id="clin_108199"><div><strong>Increased circulating hemoglobin concentration</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>108199</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0549448</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Finding</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Concentration of hemoglobin in the blood circulation above the upper limit of normal.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/108199">Feature record</a> | <a href="/medgen?term=%22Increased%20circulating%20hemoglobin%20concentration%22%5BClinical%20Features%5D%20OR%20108199%5Buid%5D">Search on this feature</a></div></div>
|
||
<div class="divPopper rprt" id="clin_163397"><div><strong>Thrombocytosis</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>163397</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0836924</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Increased numbers of platelets in the peripheral blood.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/163397">Feature record</a> | <a href="/medgen?term=%22Thrombocytosis%22%5BClinical%20Features%5D%20OR%20163397%5Buid%5D">Search on this feature</a></div></div>
|
||
<div class="divPopper rprt" id="clin_377869"><div><strong>Increased red blood cell mass</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>377869</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1853288</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Finding</dd></dl></div></div></div>
|
||
<div class="spaceAbove">The presence of an increased mass of red blood cells in the circulation.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/377869">Feature record</a> | <a href="/medgen?term=%22Increased%20red%20blood%20cell%20mass%22%5BClinical%20Features%5D%20OR%20377869%5Buid%5D">Search on this feature</a></div></div>
|
||
<div class="divPopper rprt" id="clin_870733"><div><strong>Increased megakaryocyte count</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>870733</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C4025187</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Finding</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Increased megakaryocyte number, i.e., of platelet precursor cells, present in the bone marrow.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/870733">Feature record</a> | <a href="/medgen?term=%22Increased%20megakaryocyte%20count%22%5BClinical%20Features%5D%20OR%20870733%5Buid%5D">Search on this feature</a></div></div>
|
||
<div class="divPopper rprt" id="clin_871247"><div><strong>Abnormal thrombosis</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>871247</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C4025731</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Anatomical Abnormality</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Venous or arterial thrombosis (formation of blood clots) of spontaneous nature and which cannot be fully explained by acquired risk (e.g. atherosclerosis).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/871247">Feature record</a> | <a href="/medgen?term=%22Abnormal%20thrombosis%22%5BClinical%20Features%5D%20OR%20871247%5Buid%5D">Search on this feature</a></div></div>
|
||
<div class="divPopper rprt" id="clin_9736"><div><strong>Leukocytosis</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>9736</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0023518</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">An abnormal increase in the number of leukocytes in the blood.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/9736">Feature record</a> | <a href="/medgen?term=%22Leukocytosis%22%5BClinical%20Features%5D%20OR%209736%5Buid%5D">Search on this feature</a></div></div>
|
||
<div class="divPopper rprt" id="clin_52469"><div><strong>Splenomegaly</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>52469</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0038002</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Finding</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Abnormal increased size of the spleen.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/52469">Feature record</a> | <a href="/medgen?term=%22Splenomegaly%22%5BClinical%20Features%5D%20OR%2052469%5Buid%5D">Search on this feature</a></div></div><div class="TreeLite" data-jigconfig="closed: 1"><div class="concept-def"><a class="small" href="#" onclick="jQuery(".TreeLite","#ID_102").TreeLite().openAll(); return false;">Show all</a><a class="small" href="#" onclick="jQuery(".TreeLite","#ID_102").TreeLite().closeAll(); return false;">Hide all</a></div><ul><li><span class="TLline">Abnormality of blood and blood-forming tissues</span><ul><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_871247" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Abnormal thrombosis</a></span></li><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_108199" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Increased circulating hemoglobin concentration</a></span></li><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_68692" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Increased hematocrit</a></span></li><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_870733" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Increased megakaryocyte count</a></span></li><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_377869" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Increased red blood cell mass</a></span></li><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_52737" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Thrombocytopenia</a></span></li><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_163397" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Thrombocytosis</a></span></li><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_21532" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Thromboembolism</a></span></li></ul></li><li><span class="TLline">Abnormality of the cardiovascular system</span><ul><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_163632" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Budd-Chiari syndrome</a></span></li><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_423648" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Cerebral hemorrhage</a></span></li><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_182975" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Cerebral ischemia</a></span></li></ul></li><li><span class="TLline">Abnormality of the digestive system</span><ul><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_8971" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Gastrointestinal hemorrhage</a></span></li></ul></li><li><span class="TLline">Abnormality of the immune system</span><ul><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_9736" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Leukocytosis</a></span></li><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_52469" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Splenomegaly</a></span></li></ul></li></ul></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_118">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Term_Hierarchy">Term Hierarchy</h1><a sid="118" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln HierarchyGTR"><div class="jig-ncbitabs"><ul><li><a href="#tabGTR">GTR</a></li><li><a href="#tabMGEN">MeSH</a></li><li><a href="#tabORDO">Orphanet</a></li></ul><div id="tabGTR"><div class="search_result"><div class="rprts"><div class="chiclet_legend"><span class="chiclet_list" style="position:static;"><span title="Clinical test" class="chiclet Ccolor round">C</span><span>Clinical test, </span><span title="Research test" class="chiclet Rcolor round">R</span><span>Research test, </span><span title="OMIM" class="chiclet Ocolor ">O</span><span>OMIM, </span><span title="GeneReview" class="chiclet Gcolor">G</span><span><em>GeneReviews</em>, </span><span title="ClinVar" class="chiclet Vcolor">V</span><span>ClinVar </span></span></div><div id="hierarchy" class="margin_t1"><div class="ds_tree"><ul><li class="matched_ds"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C0032463[DISCUI]&test_type=Clinical" ref="ncbi_uid=45996">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet Ocolor" title="OMIM"><a ref="ncbi_uid=45996" target="_blank" href="/omim/263300">O</a></span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&from_uid=45996" ref="ncbi_uid=45996">V</a></span></span><span class="TLline">Acquired polycythemia vera</span></li></ul></div></div></div></div></div><div id="tabMGEN"><div class="ds_tree"><ul><li><span class="TLline"><a href="/medgen/4347" ref="tree=MeSH" title="MedGen record for Disease">Disease</a></span><ul><li><span class="TLline"><a href="/medgen/232130" ref="tree=MeSH" title="MedGen record for Disorder by Site">Disorder by Site</a></span><ul><li><span class="TLline"><a href="/medgen/208860" ref="tree=MeSH" title="MedGen record for Hematopoietic and Lymphatic System Disorder">Hematopoietic and Lymphatic System Disorder</a></span><ul><li><span class="TLline"><a href="/medgen/5483" ref="tree=MeSH" title="MedGen record for Hematologic disorder">Hematologic disorder</a></span><ul><li><span class="TLline"><a href="/medgen/2311" ref="tree=MeSH" title="MedGen record for Bone marrow disorder">Bone marrow disorder</a></span><ul><li><span class="TLline"><a href="/medgen/129203" ref="tree=MeSH" title="MedGen record for Bone marrow neoplasm">Bone marrow neoplasm</a></span><ul><li><span class="matched_ds">Acquired polycythemia vera</span><ul><li><span class="TLline"><a href="/medgen/271322" ref="tree=MeSH" title="MedGen record for Polycythemia Vera, Polycythemic Phase">Polycythemia Vera, Polycythemic Phase</a></span></li><li><span class="TLline"><a href="/medgen/1641083" ref="tree=MeSH" title="MedGen record for Polycythemia Vera, Post-Polycythemic Myelofibrosis Phase">Polycythemia Vera, Post-Polycythemic Myelofibrosis Phase</a></span></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></div></div><div id="tabORDO">Follow <a target="_blank" href="http://www.orpha.net/consor/cgi-bin/Disease_Classif.php?lng=EN&data_id=156&PatId=8747&search=Disease_Classif_Simple&new=1" class="ital bold">this link</a> to review classifications for <span class="ital">Acquired polycythemia vera</span> in Orphanet.</div></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_105">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Professional_guidelines">Professional guidelines</h1><a sid="105" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">PubMed<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpPM"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/39556352">Diagnosis and Treatment of Polycythemia Vera: A Review.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Tremblay D,
|
||
Kremyanskaya M,
|
||
Mascarenhas J,
|
||
Hoffman R</span><br />
|
||
<span class="medgenPMjournal">JAMA</span>
|
||
2025 Jan 14;333(2):153-160.
|
||
doi: 10.1001/jama.2024.20377.
|
||
<span class="bold">PMID: </span><a href="/pubmed/39556352" target="_blank">39556352</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/36966432">JAK2 unmutated erythrocytosis: 2023 Update on diagnosis and management.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Gangat N,
|
||
Szuber N,
|
||
Tefferi A</span><br />
|
||
<span class="medgenPMjournal">Am J Hematol</span>
|
||
2023 Jun;98(6):965-981.
|
||
Epub 2023 Apr 3
|
||
doi: 10.1002/ajh.26920.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36966432" target="_blank">36966432</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/28948496">Risk Factors for and Management of MPN-Associated Bleeding and Thrombosis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Martin K</span><br />
|
||
<span class="medgenPMjournal">Curr Hematol Malig Rep</span>
|
||
2017 Oct;12(5):389-396.
|
||
doi: 10.1007/s11899-017-0400-3.
|
||
<span class="bold">PMID: </span><a href="/pubmed/28948496" target="_blank">28948496</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(acquired%20polycythemia%20vera)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">See all (29)</a></div><h3 class="subhead">Curated<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpCurated"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3><h3 class="nl vspace"><a href="https://www.nccn.org/professionals/physician_gls/pdf/mpn.pdf" target="_blank">NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®), Myeloproliferative Neoplasms, 2023</a></h3>
|
||
</div>
|
||
</div>
|
||
<div class="display-none help-popup" id="guidelinesHelpPM">These guidelines are articles in PubMed that match specific search criteria developed by MedGen to capture the most relevant practice guidelines. This list may not be comprehensive and may include broader topics as well. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div><div class="display-none help-popup" id="guidelinesHelpCurated">These guidelines are manually curated by the MedGen team
|
||
to supplement articles available in PubMed. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div>
|
||
<div class="portlet mgSection" id="ID_103">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_clinical_studies">Recent clinical studies</h1><a sid="103" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">Etiology</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/36966432">JAK2 unmutated erythrocytosis: 2023 Update on diagnosis and management.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Gangat N,
|
||
Szuber N,
|
||
Tefferi A</span><br />
|
||
<span class="medgenPMjournal">Am J Hematol</span>
|
||
2023 Jun;98(6):965-981.
|
||
Epub 2023 Apr 3
|
||
doi: 10.1002/ajh.26920.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36966432" target="_blank">36966432</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/34021251">JAK2 unmutated erythrocytosis: current diagnostic approach and therapeutic views.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Gangat N,
|
||
Szuber N,
|
||
Pardanani A,
|
||
Tefferi A</span><br />
|
||
<span class="medgenPMjournal">Leukemia</span>
|
||
2021 Aug;35(8):2166-2181.
|
||
Epub 2021 May 21
|
||
doi: 10.1038/s41375-021-01290-6.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34021251" target="_blank">34021251</a><a href="/pmc/articles/PMC8324477" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/24325356">Somatic mutations of calreticulin in myeloproliferative neoplasms.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Klampfl T,
|
||
Gisslinger H,
|
||
Harutyunyan AS,
|
||
Nivarthi H,
|
||
Rumi E,
|
||
Milosevic JD,
|
||
Them NC,
|
||
Berg T,
|
||
Gisslinger B,
|
||
Pietra D,
|
||
Chen D,
|
||
Vladimer GI,
|
||
Bagienski K,
|
||
Milanesi C,
|
||
Casetti IC,
|
||
Sant'Antonio E,
|
||
Ferretti V,
|
||
Elena C,
|
||
Schischlik F,
|
||
Cleary C,
|
||
Six M,
|
||
Schalling M,
|
||
Schönegger A,
|
||
Bock C,
|
||
Malcovati L,
|
||
Pascutto C,
|
||
Superti-Furga G,
|
||
Cazzola M,
|
||
Kralovics R</span><br />
|
||
<span class="medgenPMjournal">N Engl J Med</span>
|
||
2013 Dec 19;369(25):2379-90.
|
||
Epub 2013 Dec 10
|
||
doi: 10.1056/NEJMoa1311347.
|
||
<span class="bold">PMID: </span><a href="/pubmed/24325356" target="_blank">24325356</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/20237866">Polycythemia vera.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Landolfi R,
|
||
Nicolazzi MA,
|
||
Porfidia A,
|
||
Di Gennaro L</span><br />
|
||
<span class="medgenPMjournal">Intern Emerg Med</span>
|
||
2010 Oct;5(5):375-84.
|
||
Epub 2010 Mar 16
|
||
doi: 10.1007/s11739-010-0369-6.
|
||
<span class="bold">PMID: </span><a href="/pubmed/20237866" target="_blank">20237866</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/11640868">Myeloproliferative disorders.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Bench AJ,
|
||
Cross NC,
|
||
Huntly BJ,
|
||
Nacheva EP,
|
||
Green AR</span><br />
|
||
<span class="medgenPMjournal">Best Pract Res Clin Haematol</span>
|
||
2001 Sep;14(3):531-51.
|
||
doi: 10.1053/beha.2001.0153.
|
||
<span class="bold">PMID: </span><a href="/pubmed/11640868" target="_blank">11640868</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Acquired%20polycythemia%20vera%22%20AND%20Etiology%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (126)</a></div><h3 class="subhead">Diagnosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/38695361">Erythrocytosis: Diagnosis and investigation.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Noumani I,
|
||
Harrison CN,
|
||
McMullin MF</span><br />
|
||
<span class="medgenPMjournal">Int J Lab Hematol</span>
|
||
2024 May;46 Suppl 1:55-62.
|
||
Epub 2024 May 2
|
||
doi: 10.1111/ijlh.14298.
|
||
<span class="bold">PMID: </span><a href="/pubmed/38695361" target="_blank">38695361</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/38621632">Erythrocytosis and CKD: A Review.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Aoun M,
|
||
Jadoul M,
|
||
Anders HJ</span><br />
|
||
<span class="medgenPMjournal">Am J Kidney Dis</span>
|
||
2024 Oct;84(4):495-506.
|
||
Epub 2024 Apr 15
|
||
doi: 10.1053/j.ajkd.2024.02.015.
|
||
<span class="bold">PMID: </span><a href="/pubmed/38621632" target="_blank">38621632</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/36966432">JAK2 unmutated erythrocytosis: 2023 Update on diagnosis and management.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Gangat N,
|
||
Szuber N,
|
||
Tefferi A</span><br />
|
||
<span class="medgenPMjournal">Am J Hematol</span>
|
||
2023 Jun;98(6):965-981.
|
||
Epub 2023 Apr 3
|
||
doi: 10.1002/ajh.26920.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36966432" target="_blank">36966432</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/36347013">Genetic basis and molecular profiling in myeloproliferative neoplasms.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Luque Paz D,
|
||
Kralovics R,
|
||
Skoda RC</span><br />
|
||
<span class="medgenPMjournal">Blood</span>
|
||
2023 Apr 20;141(16):1909-1921.
|
||
doi: 10.1182/blood.2022017578.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36347013" target="_blank">36347013</a><a href="/pmc/articles/PMC10646774" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/34021251">JAK2 unmutated erythrocytosis: current diagnostic approach and therapeutic views.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Gangat N,
|
||
Szuber N,
|
||
Pardanani A,
|
||
Tefferi A</span><br />
|
||
<span class="medgenPMjournal">Leukemia</span>
|
||
2021 Aug;35(8):2166-2181.
|
||
Epub 2021 May 21
|
||
doi: 10.1038/s41375-021-01290-6.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34021251" target="_blank">34021251</a><a href="/pmc/articles/PMC8324477" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Acquired%20polycythemia%20vera%22%20AND%20Diagnosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (136)</a></div><h3 class="subhead">Therapy</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/36966432">JAK2 unmutated erythrocytosis: 2023 Update on diagnosis and management.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Gangat N,
|
||
Szuber N,
|
||
Tefferi A</span><br />
|
||
<span class="medgenPMjournal">Am J Hematol</span>
|
||
2023 Jun;98(6):965-981.
|
||
Epub 2023 Apr 3
|
||
doi: 10.1002/ajh.26920.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36966432" target="_blank">36966432</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/27423232">Investigation and Management of Erythrocytosis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">McMullin MF</span><br />
|
||
<span class="medgenPMjournal">Curr Hematol Malig Rep</span>
|
||
2016 Oct;11(5):342-7.
|
||
doi: 10.1007/s11899-016-0334-1.
|
||
<span class="bold">PMID: </span><a href="/pubmed/27423232" target="_blank">27423232</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/20237866">Polycythemia vera.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Landolfi R,
|
||
Nicolazzi MA,
|
||
Porfidia A,
|
||
Di Gennaro L</span><br />
|
||
<span class="medgenPMjournal">Intern Emerg Med</span>
|
||
2010 Oct;5(5):375-84.
|
||
Epub 2010 Mar 16
|
||
doi: 10.1007/s11739-010-0369-6.
|
||
<span class="bold">PMID: </span><a href="/pubmed/20237866" target="_blank">20237866</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/17210076">Essential thrombocythemia.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Brière JB</span><br />
|
||
<span class="medgenPMjournal">Orphanet J Rare Dis</span>
|
||
2007 Jan 8;2:3.
|
||
doi: 10.1186/1750-1172-2-3.
|
||
<span class="bold">PMID: </span><a href="/pubmed/17210076" target="_blank">17210076</a><a href="/pmc/articles/PMC1781427" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/11317965">Idiopathic erythrocytosis, diagnosis and clinical management.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Pearson TC,
|
||
Messinezy M</span><br />
|
||
<span class="medgenPMjournal">Pathol Biol (Paris)</span>
|
||
2001 Mar;49(2):170-7.
|
||
doi: 10.1016/s0369-8114(00)00025-0.
|
||
<span class="bold">PMID: </span><a href="/pubmed/11317965" target="_blank">11317965</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Acquired%20polycythemia%20vera%22%20AND%20Therapy%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (60)</a></div><h3 class="subhead">Prognosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/38695361">Erythrocytosis: Diagnosis and investigation.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Noumani I,
|
||
Harrison CN,
|
||
McMullin MF</span><br />
|
||
<span class="medgenPMjournal">Int J Lab Hematol</span>
|
||
2024 May;46 Suppl 1:55-62.
|
||
Epub 2024 May 2
|
||
doi: 10.1111/ijlh.14298.
|
||
<span class="bold">PMID: </span><a href="/pubmed/38695361" target="_blank">38695361</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/36347013">Genetic basis and molecular profiling in myeloproliferative neoplasms.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Luque Paz D,
|
||
Kralovics R,
|
||
Skoda RC</span><br />
|
||
<span class="medgenPMjournal">Blood</span>
|
||
2023 Apr 20;141(16):1909-1921.
|
||
doi: 10.1182/blood.2022017578.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36347013" target="_blank">36347013</a><a href="/pmc/articles/PMC10646774" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/34021251">JAK2 unmutated erythrocytosis: current diagnostic approach and therapeutic views.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Gangat N,
|
||
Szuber N,
|
||
Pardanani A,
|
||
Tefferi A</span><br />
|
||
<span class="medgenPMjournal">Leukemia</span>
|
||
2021 Aug;35(8):2166-2181.
|
||
Epub 2021 May 21
|
||
doi: 10.1038/s41375-021-01290-6.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34021251" target="_blank">34021251</a><a href="/pmc/articles/PMC8324477" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/24325356">Somatic mutations of calreticulin in myeloproliferative neoplasms.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Klampfl T,
|
||
Gisslinger H,
|
||
Harutyunyan AS,
|
||
Nivarthi H,
|
||
Rumi E,
|
||
Milosevic JD,
|
||
Them NC,
|
||
Berg T,
|
||
Gisslinger B,
|
||
Pietra D,
|
||
Chen D,
|
||
Vladimer GI,
|
||
Bagienski K,
|
||
Milanesi C,
|
||
Casetti IC,
|
||
Sant'Antonio E,
|
||
Ferretti V,
|
||
Elena C,
|
||
Schischlik F,
|
||
Cleary C,
|
||
Six M,
|
||
Schalling M,
|
||
Schönegger A,
|
||
Bock C,
|
||
Malcovati L,
|
||
Pascutto C,
|
||
Superti-Furga G,
|
||
Cazzola M,
|
||
Kralovics R</span><br />
|
||
<span class="medgenPMjournal">N Engl J Med</span>
|
||
2013 Dec 19;369(25):2379-90.
|
||
Epub 2013 Dec 10
|
||
doi: 10.1056/NEJMoa1311347.
|
||
<span class="bold">PMID: </span><a href="/pubmed/24325356" target="_blank">24325356</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/20237866">Polycythemia vera.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Landolfi R,
|
||
Nicolazzi MA,
|
||
Porfidia A,
|
||
Di Gennaro L</span><br />
|
||
<span class="medgenPMjournal">Intern Emerg Med</span>
|
||
2010 Oct;5(5):375-84.
|
||
Epub 2010 Mar 16
|
||
doi: 10.1007/s11739-010-0369-6.
|
||
<span class="bold">PMID: </span><a href="/pubmed/20237866" target="_blank">20237866</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Acquired%20polycythemia%20vera%22%20AND%20Prognosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (66)</a></div><h3 class="subhead">Clinical prediction guides</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/38695361">Erythrocytosis: Diagnosis and investigation.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Noumani I,
|
||
Harrison CN,
|
||
McMullin MF</span><br />
|
||
<span class="medgenPMjournal">Int J Lab Hematol</span>
|
||
2024 May;46 Suppl 1:55-62.
|
||
Epub 2024 May 2
|
||
doi: 10.1111/ijlh.14298.
|
||
<span class="bold">PMID: </span><a href="/pubmed/38695361" target="_blank">38695361</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/36347013">Genetic basis and molecular profiling in myeloproliferative neoplasms.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Luque Paz D,
|
||
Kralovics R,
|
||
Skoda RC</span><br />
|
||
<span class="medgenPMjournal">Blood</span>
|
||
2023 Apr 20;141(16):1909-1921.
|
||
doi: 10.1182/blood.2022017578.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36347013" target="_blank">36347013</a><a href="/pmc/articles/PMC10646774" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/35153004">Lab tests for MPN.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Moncada A,
|
||
Pancrazzi A</span><br />
|
||
<span class="medgenPMjournal">Int Rev Cell Mol Biol</span>
|
||
2022;366:187-220.
|
||
Epub 2021 Apr 5
|
||
doi: 10.1016/bs.ircmb.2021.02.010.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35153004" target="_blank">35153004</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/15781101">Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Baxter EJ,
|
||
Scott LM,
|
||
Campbell PJ,
|
||
East C,
|
||
Fourouclas N,
|
||
Swanton S,
|
||
Vassiliou GS,
|
||
Bench AJ,
|
||
Boyd EM,
|
||
Curtin N,
|
||
Scott MA,
|
||
Erber WN,
|
||
Green AR;
|
||
Cancer Genome Project</span><br />
|
||
<span class="medgenPMjournal">Lancet</span>
|
||
2005 Mar 19-25;365(9464):1054-61.
|
||
doi: 10.1016/S0140-6736(05)71142-9.
|
||
<span class="bold">PMID: </span><a href="/pubmed/15781101" target="_blank">15781101</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/11317965">Idiopathic erythrocytosis, diagnosis and clinical management.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Pearson TC,
|
||
Messinezy M</span><br />
|
||
<span class="medgenPMjournal">Pathol Biol (Paris)</span>
|
||
2001 Mar;49(2):170-7.
|
||
doi: 10.1016/s0369-8114(00)00025-0.
|
||
<span class="bold">PMID: </span><a href="/pubmed/11317965" target="_blank">11317965</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Acquired%20polycythemia%20vera%22%20AND%20Clinical%20prediction%20guides%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (71)</a></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_104">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_systematic_reviews">Recent systematic reviews</h1><a sid="104" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln">
|
||
<div class="nl"><a target="_blank" href="/pubmed/34645293">Environmental Factors, Lifestyle Risk Factors, and Host Characteristics Associated With Philadelphia Negative Myeloproliferative Neoplasm: A Systematic Review.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Allahverdi N,
|
||
Yassin M,
|
||
Ibrahim M</span><br />
|
||
<span class="medgenPMjournal">Cancer Control</span>
|
||
2021 Jan-Dec;28:10732748211046802.
|
||
doi: 10.1177/10732748211046802.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34645293" target="_blank">34645293</a><a href="/pmc/articles/PMC8521755" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Acquired%20polycythemia%20vera%22%20AND%20systematic%5Bsb%5D%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (1)</a></div></div>
|
||
</div>
|
||
</div></div></div></div></div></div></div>
|
||
<div id="messagearea_bottom">
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</div>
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<div class=" bottom">
|
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|
||
</div>
|
||
|
||
</div>
|
||
</div>
|
||
<div class="supplemental col three_col last">
|
||
<h2 class="offscreen_noflow">Supplemental Content</h2>
|
||
|
||
<div>
|
||
|
||
<!-- MedGen supplemental column starts here -->
|
||
<div class="rightCol mgCol">
|
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<div class="portlet mgSection" id="ID_113">
|
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Table_of_contents">Table of contents</h1><a sid="113" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
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<div class="portlet_content ln"><ul id="my-toc"></ul></div>
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|
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|
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<div class="portlet mgSection" id="ID_106">
|
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Genetic_Testing_Registry">Genetic Testing Registry</h1><a sid="106" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><ul><li><a href="/gtr/tests?term=C0032463%5bDISCUI%5d&filter=method%3A2%5F8" target="_blank">Deletion/duplication analysis (9)</a></li>
|
||
<li><a href="/gtr/tests?term=C0032463%5bDISCUI%5d&filter=method%3A3%5F23" target="_blank">FISH-interphase (2)</a></li>
|
||
<li><a href="/gtr/tests?term=C0032463%5bDISCUI%5d&filter=method%3A2%5F9" target="_blank">Sequence analysis of select exons (4)</a></li>
|
||
<li><a href="/gtr/tests?term=C0032463%5bDISCUI%5d&filter=method%3A2%5F7" target="_blank">Sequence analysis of the entire coding region (14)</a></li>
|
||
<li><a href="/gtr/tests?term=C0032463%5bDISCUI%5d&filter=method%3A2%5F19" target="_blank">Targeted variant analysis (48)</a></li>
|
||
<li class="portletSeeAll portletSeeAllPad"><total><a href="/gtr/tests?term=C0032463%5bDISCUI%5d" target="_blank">See all (66)</a></total></li>
|
||
</ul></div>
|
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|
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<div class="portlet mgSection" id="ID_119">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Clinical_resources">Clinical resources</h1><a sid="119" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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||
<div class="portlet_content ln"><ul><li><a href="https://www.omim.org/search?index=entry&start=1&limit=10&sort=score%20desc&field=number&search=263300" target="_blank">OMIM</a></li><li><a href="http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Expert=729" target="_blank">Orphanet</a></li><li><a href="https://clinicaltrials.gov/search?cond=Acquired%20polycythemia%20vera" target="_blank">ClinicalTrials.gov</a></li></ul></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_121">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Practice_guidelines">Practice guidelines</h1><a sid="121" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="portlet_content ln"><ul class="a_poppers"><li><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(acquired%20polycythemia%20vera)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">PubMed</a><div class="help-popup">See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div></li><li><a target="_blank" href="/books/?term=((%22clinical%20guidelines%22%5BResource%20Type%5D)%20OR%20%22practice%20guideline%22%5BPublication%20Type%5D)%20AND%20(%22Acquired%20polycythemia%20vera%22)">Bookshelf</a><div class="help-popup">See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div></li></ul><h3 class="subhead">Curated</h3><ul class="a_poppers"><li><a target="_blank" href="https://www.nccn.org/professionals/physician_gls/pdf/mpn.pdf">NCCN, 2023</a><div>NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®), Myeloproliferative Neoplasms, 2023</div></li></ul></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_115">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Molecular_resources">Molecular resources</h1><a sid="115" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><ul><li><a href="http://www.omim.org/search?index=entry&start=1&limit=10&sort=score%20desc&field=number&search=147796" target="_blank">OMIM</a></li><li><a href="/clinvar/?term=3717[geneid]" target="_blank">View JAK2 variations in ClinVar</a></li><li><a href="/nuccore/224451097" target="_blank">RefSeqGene</a></li><li><a href="https://catalog.coriell.org/Search?q=263300" target="_blank">Coriell Institute for Medical Research</a></li></ul></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_116">
|
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Consumer_resources">Consumer resources</h1><a sid="116" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><ul><li><a href="http://www.diseaseinfosearch.org/Polycythemia+vera/5826" target="_blank">Genetic Alliance</a></li><li><a href="https://www.malacards.org/card/polycythemia_vera" target="_blank">MalaCards</a></li><li><a href="https://vsearch.nlm.nih.gov/vivisimo/cgi-bin/query-meta?v:project=medlineplus&query=Acquired%20polycythemia%20vera" target="_blank">MedlinePlus</a></li><li><a href="https://medlineplus.gov/genetics/condition/polycythemia-vera" target="_blank">MedlinePlusGenetics (GHR)</a></li><li><a href="https://rarediseases.info.nih.gov/diseases/7422/disease" target="_blank">NCATS Office of Rare Diseases Research (GARD)</a></li></ul></div>
|
||
</div>
|
||
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|
||
<div class="portlet brieflink">
|
||
<div class="portlet_head">
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<h3>Reviews</h3>
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<li>
|
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<a href="/pubmed/clinical?term=Acquired%20polycythemia%20vera" ref="ncbi_uid=&discoId=gtr_reviews&linkpos=1&linkpostotal=2" target="_blank">PubMed Clinical Queries</a>
|
||
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|
||
<li>
|
||
<a href="/pubmed?term=Acquired%20polycythemia%20vera%20AND%20humans[mesh]%20AND%20review[publication%20type]" ref="ncbi_uid=&discoId=gtr_reviews&linkpos=2&linkpostotal=2" target="_blank">Reviews in PubMed</a>
|
||
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|
||
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|
||
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|
||
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|
||
|
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<!-- MedGen supplemental column ends here -->
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||
<div class="portlet brieflink">
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<h3>Related information</h3>
|
||
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||
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||
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<div class="portlet_content DiscoveryDbLinks">
|
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|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/clinvar?LinkName=medgen_clinvar&from_uid=45996" ref="log$=recordlinks">ClinVar</a>
|
||
<div class="brieflinkpop offscreen_noflow">Related medical variations</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/gene?LinkName=medgen_gene_diseases&from_uid=45996" ref="log$=recordlinks">Gene</a>
|
||
<div class="brieflinkpop offscreen_noflow">Related information in NCBI Gene</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/gtr/tests?term=C0032463[DISCUI]" ref="log$=recordlinks">GTR</a>
|
||
<div class="brieflinkpop offscreen_noflow">Related information in GTR</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/gtr/tests?term=C0032463[DISCUI]&test_type=Clinical" ref="log$=recordlinks">GTR(Clinical)</a>
|
||
<div class="brieflinkpop offscreen_noflow">Clinical tests in GTR</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/mesh?LinkName=medgen_mesh&from_uid=45996" ref="log$=recordlinks">MeSH</a>
|
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<div class="brieflinkpop offscreen_noflow">Related Medical Subject Headings</div>
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<li class="brieflinkpopper">
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||
<a class="brieflinkpopperctrl" href="/omim?LinkName=medgen_omim&from_uid=45996" ref="log$=recordlinks">OMIM</a>
|
||
<div class="brieflinkpop offscreen_noflow">Related records in OMIM</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/omim?LinkName=medgen_omim_gene&from_uid=45996" ref="log$=recordlinks">OMIM(Genes)</a>
|
||
<div class="brieflinkpop offscreen_noflow">OMIM records containing genes associated with phenotypes registered in MedGen</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/pmc?LinkName=medgen_pmc&from_uid=45996" ref="log$=recordlinks">PMC Articles</a>
|
||
<div class="brieflinkpop offscreen_noflow">Related information in PubMed Central Links</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/pubmed?LinkName=medgen_pubmed&from_uid=45996" ref="log$=recordlinks">PubMed</a>
|
||
<div class="brieflinkpop offscreen_noflow">Related literature resources in PubMed</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/pubmed?LinkName=medgen_pubmed_omim&from_uid=45996" ref="log$=recordlinks">PubMed (OMIM)</a>
|
||
<div class="brieflinkpop offscreen_noflow">Related literature resources in PubMed</div>
|
||
</li>
|
||
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|
||
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|
||
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|
||
|
||
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<h3>Recent activity</h3>
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<a name="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.HistoryDisplay.ClearHistory" sid="1" realname="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.HistoryDisplay.ClearHistory" cmd="ClearHT" href="?cmd=ClearHT&" onclick="return false;" id="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.HistoryDisplay.ClearHistory">
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