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<meta name="keywords" content="C0027819, cancer of early nerve cells, nb, nb - neuroblastoma, neoplastic process, neural crest tumor, malignant, neuroblastoma, neuroblastoma (schwannian stroma-poor), neuroblastoma, malignant, neuroblastomas, autosomal dominant, autosomal recessive, birth defects, chromosomal disease, chromosome, clinical features, clinical findings, clinical genetics, clinical recommendations, clinvar, congenital chromosomal disease, consumer genetic resources, cytogenetic location, disease characteristics, disease definitions, disease descriptions, disease ontology, disease synonyms, disease vocabulary, dysmorphology, entrez, familial disease, gene, gene-disease relationship, genereviews, genetic disease, genetic disorder, genetic terminology, genetic testing registry, genetics home reference, genomic disease, gtr, hereditary disease, heritable disease, hpo, human phenotype ontology, inherited disease, management guidelines, maternal inheritance, medgen, medical genetics, medical subject headings, mesh, mitochondrial inheritance, mode of inheritance, national center for biotechnology information, national institutes of health, national library of medicine, ncbi, nih, nlm, omim, ordo, orphanet, paternal inheritance, phenome, position statements, professional practice guidelines, rare disease, reference sequence, refseq, snomed ct, syndrome, undiagnosed diseases, x-linked recessive" /><meta name="description" content="ALK-related neuroblastic tumor susceptibility is characterized by increased risk for neuroblastic tumors including neuroblastomas, ganglioneuroblastomas, and ganglioneuromas. Neuroblastomas are a more malignant tumor and ganglioneuromas a more benign tumor. Depending on the histologic findings, ganglioneuroblastomas can behave in a more aggressive fashion, like neuroblastomas, or in a benign fashion, like ganglioneuromas. The overall penetrance of a germline ALK pathogenic variant is approximately 50%, with the risk for neuroblastic tumor development highest in infancy and decreasing by late childhood." /><meta name="robots" content="index,nofollow,noarchive" />
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<!--
|
||
UID=18012
|
||
ConceptID=C0027819
|
||
-->
|
||
<!--imgCountBooks = 0--><h1 class="medgenTitle"><div class="MedGenTitleText">Neuroblastoma<span class="h1sub">(NB)</span></div></h1><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>18012</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information."><span class="highlight" style="background-color:">C0027819</span></a></dd><dt><span class="dotprefix"> •</span></dt><dd>Neoplastic Process</dd></dl></div></div><table class="medgenTable"><tbody><tr><td>Synonym:</td>
|
||
<td>NB</td></tr>
|
||
<tr><td><span class="bold">SNOMED CT: </span></td>
|
||
<td>NB - Neuroblastoma (87364003); Neuroblastoma (87364003); Neuroblastoma (432328008)</td></tr>
|
||
<tr><td>Modes of inheritance:</td>
|
||
<td>
|
||
<div class="divPopper rprt" id="moi_988794"><div><strong>Not genetically inherited</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>988794</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier assigned by MedGen (starting with CN) for terms that cannot be identified in NLM's Unified Medical Language system (UMLS) Click for more information.">CN307044</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Finding</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Source: Orphanet</div>
|
||
<div class="spaceAbove">clinical entity without genetic inheritance.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/988794">This record</a></div></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#moi_988794" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Not genetically inherited</a><span> (Orphanet)</span></div></td></tr>
|
||
<tr><td colspan="2" class="small"> </td></tr><tr><td><a class="help" data-jig="ncbipopper" href="#target-gene-related">Related genes:<img src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a><div id="target-gene-related" class="display-none">
|
||
Gene(s) associated with related conditions. For conditions<br />
|
||
in a hierarchy, the parent condition will list the genes<br />
|
||
associated with the children conditions.</div></td>
|
||
<td><a target="_blank" href="/gene/23095">KIF1B</a>, <a target="_blank" href="/gene/8929">PHOX2B</a>, <a target="_blank" href="/gene/238">ALK</a></td></tr><tr><td colspan="2" class="small"> </td></tr><tr><td>HPO:</td>
|
||
<td><a target="_blank" title="Human Phenotype Ontology" href="https://hpo.jax.org/app/browse/term/HP:0003006">HP:0003006</a></td></tr>
|
||
<tr><td>Monarch Initiative:</td>
|
||
<td><a href="https://monarchinitiative.org/disease/MONDO:0005072" target="_blank">MONDO:0005072</a></td></tr>
|
||
<tr><td>Orphanet:</td>
|
||
<td><a target="_blank" title="Orphanet: The portal for rare diseases and orphan drugs" href="http://www.orpha.net/consor/cgi-bin/OC_Exp.php?lng=EN&Expert=635">ORPHA635</a></td></tr></tbody></table></div><div class="rprt-body jig-ncbiinpagenav" data-jigconfig="smoothScroll: false, gotoTopLink: true, gotoTopLinkText: '', gotoTopLinkAttrs: {'title': 'Go to the top of the page'},allHeadingLevels: ['h1'], topOfPageTOC: true, tocId: 'my-toc'"><div id="rprt-tabs-1" class="rprt-tab"><div id="tb-termsProp-1"><div class="leftCol mgCol"><div>
|
||
<div class="portlet mgSection" id="ID_101">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Disease_characteristics">Disease characteristics</h1><a sid="101" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><div class="excerpt">Excerpted from the <i>GeneReview: </i><a href="/books/NBK24599" target="_blank">ALK-Related Neuroblastic Tumor Susceptibility</a></div><div>ALK-related neuroblastic tumor susceptibility is characterized by increased risk for neuroblastic tumors including neuroblastomas, ganglioneuroblastomas, and ganglioneuromas. Neuroblastomas are a more malignant tumor and ganglioneuromas a more benign tumor. Depending on the histologic findings, ganglioneuroblastomas can behave in a more aggressive fashion, like neuroblastomas, or in a benign fashion, like ganglioneuromas. The overall penetrance of a germline ALK pathogenic variant is approximately 50%, with the risk for neuroblastic tumor development highest in infancy and decreasing by late childhood. [from <a title="GeneReviews" href="https://www.ncbi.nlm.nih.gov/books/NBK1116" class="defSource" target="_blank">GeneReviews</a>]</div><div class="spaceAbove"><strong>Full text of <i>GeneReview</i> (by section):</strong><br /><a class="medgenPMinfo" href="/books/NBK24599#alk-nbs.Summary" target="NBK24599">Summary</a> | <a class="medgenPMinfo" href="/books/NBK24599#alk-nbs.GeneReview_Scope" target="NBK24599">GeneReview Scope</a> | <a class="medgenPMinfo" href="/books/NBK24599#alk-nbs.Diagnosis" target="NBK24599">Diagnosis</a> | <a class="medgenPMinfo" href="/books/NBK24599#alk-nbs.Clinical_Characteristics" target="NBK24599">Clinical Characteristics</a> | <a class="medgenPMinfo" href="/books/NBK24599#alk-nbs.Genetically_Related_Allelic_Diso" target="NBK24599">Genetically Related (Allelic) Disorders</a> | <a class="medgenPMinfo" href="/books/NBK24599#alk-nbs.Differential_Diagnosis" target="NBK24599">Differential Diagnosis</a> | <a class="medgenPMinfo" href="/books/NBK24599#alk-nbs.Management" target="NBK24599">Management</a> | <a class="medgenPMinfo" href="/books/NBK24599#alk-nbs.Genetic_Counseling" target="NBK24599">Genetic Counseling</a> | <a class="medgenPMinfo" href="/books/NBK24599#alk-nbs.Resources" target="NBK24599">Resources</a> | <a class="medgenPMinfo" href="/books/NBK24599#alk-nbs.Molecular_Genetics" target="NBK24599">Molecular Genetics</a> | <a class="medgenPMinfo" href="/books/NBK24599#alk-nbs.Chapter_Notes" target="NBK24599">Chapter Notes</a> | <a class="medgenPMinfo" href="/books/NBK24599#alk-nbs.References" target="NBK24599">References</a></div><div class="spaceAbove"><strong>Authors:</strong><br />
|
||
Emily G Greengard | Melissa R Perrino | Julie R Park <a href="/books/NBK24599" target="NBK24599" title="NCBI Bookshelf: ALK-Related Neuroblastic Tumor Susceptibility">view full author information</a></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_117">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Additional_description">Additional description</h1><a sid="117" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><div class="mgSection"><strong>From OMIM</strong><br />Neuroblastoma is the most common childhood cancer diagnosed before the age of 1 year, and accounts for 10 to 15% of all cancer deaths in children. Some patients inherit a genetic predisposition to neuroblastoma due to germline mutations, whereas others develop sporadic disease that may result from either germline or somatic mutations. Neuroblastoma tumors are derived from embryonic cells that form the primitive neural crest and give rise to the adrenal medulla and the sympathetic nervous system (Roberts et al., 1998; Eng, 2008). Histopathologically, neuroblastoma can range in type from the most aggressive form, neuroblastoma, composed entirely of immature neural precursor cells, to ganglioneuroma, composed entirely of mature neural tissue. The most important prognostic factor for patients with neuroblastoma is the extent of the tumor at the time of diagnosis (Roberts et al., 1998).
|
||
Neuroblastoma can also be part of cancer-prone syndromes, such as paragangliomas (see, e.g., PGL4; 115310).
|
||
Genetic Heterogeneity of Susceptibility to Neuroblastoma
|
||
Susceptibility to neuroblastoma is genetically heterogeneous and is conferred by mutation in the PHOX2B gene (603851) on chromosome 4p12 (NBLST2; 613013) and by mutation in the ALK gene (105590) on chromosome 2p23 (NBLST3; 613014).
|
||
Loci implicated in the development of neuroblastoma include 6p (NBLST4; 613015), 2q35 (NBLST5; 613016), and 1q21 (NBLST6; 613017). <a target="_blank" href="http://www.omim.org/entry/256700">http://www.omim.org/entry/256700</a></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_118">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Term_Hierarchy">Term Hierarchy</h1><a sid="118" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln HierarchyGTR"><div class="jig-ncbitabs"><ul><li><a href="#tabGTR">GTR</a></li><li><a href="#tabMGEN">MeSH</a></li></ul><div id="tabGTR"><div class="search_result"><div class="rprts"><div class="chiclet_legend"><span class="chiclet_list" style="position:static;"><span title="Clinical test" class="chiclet Ccolor round">C</span><span>Clinical test, </span><span title="Research test" class="chiclet Rcolor round">R</span><span>Research test, </span><span title="OMIM" class="chiclet Ocolor ">O</span><span>OMIM, </span><span title="GeneReview" class="chiclet Gcolor">G</span><span><em>GeneReviews</em>, </span><span title="ClinVar" class="chiclet Vcolor">V</span><span>ClinVar </span></span></div><div id="hierarchy" class="margin_t1"><div class="ds_tree"><ul><li class="matched_ds"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C0027819[DISCUI]&test_type=Clinical" ref="ncbi_uid=18012">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet unavailable" title="OMIM">O</span><span class="chiclet Gcolor" title="GeneReviews"><a target="_blank" href="/books/NBK24599/" ref="ncbi_uid=18012">G</a></span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&from_uid=18012" ref="ncbi_uid=18012">V</a></span></span><span class="TLline">Neuroblastoma</span><ul><li class="TLclosed"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C2749485[DISCUI]&test_type=Clinical" ref="ncbi_uid=412713">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet Ocolor" title="OMIM"><a ref="ncbi_uid=412713" target="_blank" href="/omim/256700">O</a></span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&from_uid=412713" ref="ncbi_uid=412713">V</a></span></span><span class="TLline"><a href="/medgen/412713" ref="tree=GTR&ncbi_uid=412713&link_uid=412713" title="View MedGen record for 'Neuroblastoma, susceptibility to, 1'">Neuroblastoma, susceptibility to, 1</a></span></li><li class="TLclosed"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C2751682[DISCUI]&test_type=Clinical" ref="ncbi_uid=416607">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet Ocolor" title="OMIM"><a ref="ncbi_uid=416607" target="_blank" href="/omim/603851">O</a></span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&from_uid=416607" ref="ncbi_uid=416607">V</a></span></span><span class="TLline"><a href="/medgen/416607" ref="tree=GTR&ncbi_uid=416607&link_uid=416607" title="View MedGen record for 'Neuroblastoma, susceptibility to, 2'">Neuroblastoma, susceptibility to, 2</a></span></li><li class="TLclosed"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C2751681[DISCUI]&test_type=Clinical" ref="ncbi_uid=414083">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet Ocolor" title="OMIM"><a ref="ncbi_uid=414083" target="_blank" href="/omim/105590">O</a></span><span class="chiclet Gcolor" title="GeneReviews"><a target="_blank" href="/books/NBK24599/" ref="ncbi_uid=414083">G</a></span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&from_uid=414083" ref="ncbi_uid=414083">V</a></span></span><span class="TLline"><a href="/medgen/414083" ref="tree=GTR&ncbi_uid=414083&link_uid=414083" title="View MedGen record for 'Neuroblastoma, susceptibility to, 3'">Neuroblastoma, susceptibility to, 3</a></span></li></ul></li></ul></div></div></div></div></div><div id="tabMGEN"><div class="ds_tree"><ul><li><span class="TLline"><a href="/medgen/18325" ref="tree=MeSH" title="MedGen record for Pathological process">Pathological process</a></span><ul><li><span class="TLline"><a href="/medgen/4347" ref="tree=MeSH" title="MedGen record for Disease">Disease</a></span><ul><li><span class="TLline"><a href="/medgen/10294" ref="tree=MeSH" title="MedGen record for Neoplasm">Neoplasm</a></span><ul><li><span class="TLline"><a href="/medgen/45034" ref="tree=MeSH" title="MedGen record for Embryonal neoplasm">Embryonal neoplasm</a></span><ul><li><span class="TLline"><a href="/medgen/234214" ref="tree=MeSH" title="MedGen record for Central Nervous System Embryonal Tumor">Central Nervous System Embryonal Tumor</a></span><ul><li><span class="TLline"><a href="/medgen/1389430" ref="tree=MeSH" title="MedGen record for Central nervous system Ewing sarcoma/peripheral primitive neuroectodermal tumor">Central nervous system Ewing sarcoma/peripheral primitive neuroectodermal tumor</a></span><ul><li><span class="matched_ds">Neuroblastoma</span><ul><li><span class="TLline"><a href="/medgen/107851" ref="tree=MeSH" title="MedGen record for Cerebral neuroblastoma">Cerebral neuroblastoma</a></span><ul><li><span class="TLline"><a href="/medgen/854378" ref="tree=MeSH" title="MedGen record for Childhood Central Nervous System Neuroblastoma">Childhood Central Nervous System Neuroblastoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/899659" ref="tree=MeSH" title="MedGen record for Childhood Neuroblastoma">Childhood Neuroblastoma</a></span></li><li><span class="TLline"><a href="/medgen/870538" ref="tree=MeSH" title="MedGen record for Congenital neuroblastoma">Congenital neuroblastoma</a></span></li><li><span class="TLline"><a href="/medgen/268734" ref="tree=MeSH" title="MedGen record for Differentiating neuroblastoma">Differentiating neuroblastoma</a></span></li><li><span class="TLline"><a href="/medgen/60217" ref="tree=MeSH" title="MedGen record for Esthesioneuroblastoma">Esthesioneuroblastoma</a></span><ul><li><span class="TLline"><a href="/medgen/232676" ref="tree=MeSH" title="MedGen record for Kadish Stage A Olfactory Neuroblastoma">Kadish Stage A Olfactory Neuroblastoma</a></span></li><li><span class="TLline"><a href="/medgen/235240" ref="tree=MeSH" title="MedGen record for Kadish Stage B Olfactory Neuroblastoma">Kadish Stage B Olfactory Neuroblastoma</a></span></li><li><span class="TLline"><a href="/medgen/272783" ref="tree=MeSH" title="MedGen record for Kadish Stage C Olfactory Neuroblastoma">Kadish Stage C Olfactory Neuroblastoma</a></span></li><li><span class="TLline"><a href="/medgen/233749" ref="tree=MeSH" title="MedGen record for Nasal cavity olfactory neuroblastoma">Nasal cavity olfactory neuroblastoma</a></span></li><li><span class="TLline"><a href="/medgen/857328" ref="tree=MeSH" title="MedGen record for Recurrent Olfactory Neuroblastoma">Recurrent Olfactory Neuroblastoma</a></span></li><li><span class="TLline"><a href="/medgen/1732204" ref="tree=MeSH" title="MedGen record for Sinonasal Olfactory Neuroblastoma">Sinonasal Olfactory Neuroblastoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/272601" ref="tree=MeSH" title="MedGen record for Extracranial neuroblastoma">Extracranial neuroblastoma</a></span><ul><li><span class="TLline"><a href="/medgen/164205" ref="tree=MeSH" title="MedGen record for Peripheral Neuroblastoma">Peripheral Neuroblastoma</a></span><ul><li><span class="TLline"><a href="/medgen/235313" ref="tree=MeSH" title="MedGen record for Mediastinum neuroblastoma">Mediastinum neuroblastoma</a></span></li><li><span class="TLline"><a href="/medgen/235367" ref="tree=MeSH" title="MedGen record for Neuroblastoma of the Adrenal Gland and Sympathetic Nervous System">Neuroblastoma of the Adrenal Gland and Sympathetic Nervous System</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/234803" ref="tree=MeSH" title="MedGen record for Spinal cord neuroblastoma">Spinal cord neuroblastoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/60218" ref="tree=MeSH" title="MedGen record for Ganglioneuroblastoma">Ganglioneuroblastoma</a></span><ul><li><span class="TLline"><a href="/medgen/1390376" ref="tree=MeSH" title="MedGen record for Central Nervous System Ganglioneuroblastoma">Central Nervous System Ganglioneuroblastoma</a></span><ul><li><span class="TLline"><a href="/medgen/903020" ref="tree=MeSH" title="MedGen record for Childhood Central Nervous System Ganglioneuroblastoma">Childhood Central Nervous System Ganglioneuroblastoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/901150" ref="tree=MeSH" title="MedGen record for Childhood Ganglioneuroblastoma">Childhood Ganglioneuroblastoma</a></span><ul><li><span class="TLline"><a href="/medgen/905733" ref="tree=MeSH" title="MedGen record for Childhood Ganglioneuroblastoma, Intermixed">Childhood Ganglioneuroblastoma, Intermixed</a></span></li><li><span class="TLline"><a href="/medgen/900927" ref="tree=MeSH" title="MedGen record for Childhood Ganglioneuroblastoma, Nodular">Childhood Ganglioneuroblastoma, Nodular</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/274565" ref="tree=MeSH" title="MedGen record for Intermixed schwannian stroma-rich ganglioneuroblastoma">Intermixed schwannian stroma-rich ganglioneuroblastoma</a></span><ul><li><span class="TLline"><a href="/medgen/1677195" ref="tree=MeSH" title="MedGen record for Adrenal Gland Ganglioneuroblastoma, Intermixed">Adrenal Gland Ganglioneuroblastoma, Intermixed</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/309203" ref="tree=MeSH" title="MedGen record for Nodular ganglioneuroblastoma">Nodular ganglioneuroblastoma</a></span><ul><li><span class="TLline"><a href="/medgen/1682151" ref="tree=MeSH" title="MedGen record for Adrenal Gland Ganglioneuroblastoma, Nodular">Adrenal Gland Ganglioneuroblastoma, Nodular</a></span></li><li><span class="TLline"><a href="/medgen/275792" ref="tree=MeSH" title="MedGen record for Schwannian stroma-rich and stroma-poor composite ganglioneuroblastoma">Schwannian stroma-rich and stroma-poor composite ganglioneuroblastoma</a></span></li><li><span class="TLline"><a href="/medgen/275793" ref="tree=MeSH" title="MedGen record for Stroma-dominant and stroma-poor composite ganglioneuroblastoma">Stroma-dominant and stroma-poor composite ganglioneuroblastoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/233850" ref="tree=MeSH" title="MedGen record for Peripheral ganglioneuroblastoma">Peripheral ganglioneuroblastoma</a></span><ul><li><span class="TLline"><a href="/medgen/231355" ref="tree=MeSH" title="MedGen record for Adrenal gland ganglioneuroblastoma">Adrenal gland ganglioneuroblastoma</a></span></li><li><span class="TLline"><a href="/medgen/235308" ref="tree=MeSH" title="MedGen record for Mediastinum ganglioneuroblastoma">Mediastinum ganglioneuroblastoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/1726489" ref="tree=MeSH" title="MedGen record for Recurrent Ganglioneuroblastoma">Recurrent Ganglioneuroblastoma</a></span></li><li><span class="TLline"><a href="/medgen/1726218" ref="tree=MeSH" title="MedGen record for Refractory Ganglioneuroblastoma">Refractory Ganglioneuroblastoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/858749" ref="tree=MeSH" title="MedGen record for Hereditary Neuroblastoma">Hereditary Neuroblastoma</a></span></li><li><span class="TLline"><a href="/medgen/1654932" ref="tree=MeSH" title="MedGen record for High Risk Neuroblastoma">High Risk Neuroblastoma</a></span></li><li><span class="TLline"><a href="/medgen/870533" ref="tree=MeSH" title="MedGen record for Localized neuroblastoma">Localized neuroblastoma</a></span></li><li><span class="TLline"><a href="/medgen/1660128" ref="tree=MeSH" title="MedGen record for Metastatic Neuroblastoma">Metastatic Neuroblastoma</a></span></li><li><span class="TLline"><a href="/medgen/412713" ref="tree=MeSH" title="MedGen record for Neuroblastoma, susceptibility to, 1">Neuroblastoma, susceptibility to, 1</a></span></li><li><span class="TLline"><a href="/medgen/416607" ref="tree=MeSH" title="MedGen record for Neuroblastoma, susceptibility to, 2">Neuroblastoma, susceptibility to, 2</a></span></li><li><span class="TLline"><a href="/medgen/414083" ref="tree=MeSH" title="MedGen record for Neuroblastoma, susceptibility to, 3">Neuroblastoma, susceptibility to, 3</a></span></li><li><span class="TLline"><a href="/medgen/271330" ref="tree=MeSH" title="MedGen record for Poorly Differentiated Neuroblastoma">Poorly Differentiated Neuroblastoma</a></span></li><li><span class="TLline"><a href="/medgen/78867" ref="tree=MeSH" title="MedGen record for Recurrent Neuroblastoma">Recurrent Neuroblastoma</a></span></li><li><span class="TLline"><a href="/medgen/1613939" ref="tree=MeSH" title="MedGen record for Refractory Neuroblastoma">Refractory Neuroblastoma</a></span></li><li><span class="TLline"><a href="/medgen/124496" ref="tree=MeSH" title="MedGen record for Regional Neuroblastoma">Regional Neuroblastoma</a></span></li><li><span class="TLline"><a href="/medgen/1648772" ref="tree=MeSH" title="MedGen record for Resectable Neuroblastoma">Resectable Neuroblastoma</a></span><ul><li><span class="TLline"><a href="/medgen/75855" ref="tree=MeSH" title="MedGen record for Localized Resectable Neuroblastoma">Localized Resectable Neuroblastoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/20552" ref="tree=MeSH" title="MedGen record for Retinoblastoma">Retinoblastoma</a></span><ul><li><span class="TLline"><a href="/medgen/163163" ref="tree=MeSH" title="MedGen record for bilateral retinoblastoma">bilateral retinoblastoma</a></span></li><li><span class="TLline"><a href="/medgen/83171" ref="tree=MeSH" title="MedGen record for Differentiated Retinoblastoma">Differentiated Retinoblastoma</a></span></li><li><span class="TLline"><a href="/medgen/226854" ref="tree=MeSH" title="MedGen record for Diffuse Retinoblastoma">Diffuse Retinoblastoma</a></span></li><li><span class="TLline"><a href="/medgen/75861" ref="tree=MeSH" title="MedGen record for Extraocular retinoblastoma">Extraocular retinoblastoma</a></span><ul><li><span class="TLline"><a href="/medgen/230837" ref="tree=MeSH" title="MedGen record for Pediatric extraocular retinoblastoma">Pediatric extraocular retinoblastoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/155869" ref="tree=MeSH" title="MedGen record for Hereditary retinoblastoma">Hereditary retinoblastoma</a></span></li><li><span class="TLline"><a href="/medgen/78874" ref="tree=MeSH" title="MedGen record for Intraocular retinoblastoma">Intraocular retinoblastoma</a></span><ul><li><span class="TLline"><a href="/medgen/230836" ref="tree=MeSH" title="MedGen record for Pediatric intraocular retinoblastoma">Pediatric intraocular retinoblastoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/1842255" ref="tree=MeSH" title="MedGen record for Non-hereditary retinoblastoma">Non-hereditary retinoblastoma</a></span></li><li><span class="TLline"><a href="/medgen/82965" ref="tree=MeSH" title="MedGen record for Recurrent Retinoblastoma">Recurrent Retinoblastoma</a></span></li><li><span class="TLline"><a href="/medgen/1646804" ref="tree=MeSH" title="MedGen record for Retinoblastoma by AJCC v8 Stage">Retinoblastoma by AJCC v8 Stage</a></span><ul><li><span class="TLline"><a href="/medgen/1635691" ref="tree=MeSH" title="MedGen record for Retinoblastoma by AJCC v8 Clinical Stage">Retinoblastoma by AJCC v8 Clinical Stage</a></span></li><li><span class="TLline"><a href="/medgen/1638974" ref="tree=MeSH" title="MedGen record for Retinoblastoma by AJCC v8 Pathologic Stage">Retinoblastoma by AJCC v8 Pathologic Stage</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/155870" ref="tree=MeSH" title="MedGen record for Sporadic Retinoblastoma">Sporadic Retinoblastoma</a></span></li><li><span class="TLline"><a href="/medgen/392856" ref="tree=MeSH" title="MedGen record for Trilateral retinoblastoma">Trilateral retinoblastoma</a></span></li><li><span class="TLline"><a href="/medgen/137788" ref="tree=MeSH" title="MedGen record for Undifferentiated Retinoblastoma">Undifferentiated Retinoblastoma</a></span></li><li><span class="TLline"><a href="/medgen/208929" ref="tree=MeSH" title="MedGen record for Unilateral retinoblastoma">Unilateral retinoblastoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/1667239" ref="tree=MeSH" title="MedGen record for Sellar Neuroblastoma">Sellar Neuroblastoma</a></span></li><li><span class="TLline"><a href="/medgen/236948" ref="tree=MeSH" title="MedGen record for Stage 1 Neuroblastoma">Stage 1 Neuroblastoma</a></span></li><li><span class="TLline"><a href="/medgen/277722" ref="tree=MeSH" title="MedGen record for Stage 2 Neuroblastoma">Stage 2 Neuroblastoma</a></span><ul><li><span class="TLline"><a href="/medgen/769601" ref="tree=MeSH" title="MedGen record for Stage 2A Neuroblastoma">Stage 2A Neuroblastoma</a></span></li><li><span class="TLline"><a href="/medgen/769602" ref="tree=MeSH" title="MedGen record for Stage 2B Neuroblastoma">Stage 2B Neuroblastoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/236894" ref="tree=MeSH" title="MedGen record for Stage 3 Neuroblastoma">Stage 3 Neuroblastoma</a></span></li><li><span class="TLline"><a href="/medgen/78866" ref="tree=MeSH" title="MedGen record for Stage 4 Neuroblastoma">Stage 4 Neuroblastoma</a></span><ul><li><span class="TLline"><a href="/medgen/210046" ref="tree=MeSH" title="MedGen record for Stage 4S Neuroblastoma">Stage 4S Neuroblastoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/274348" ref="tree=MeSH" title="MedGen record for Undifferentiated Neuroblastoma">Undifferentiated Neuroblastoma</a></span></li><li><span class="TLline"><a href="/medgen/1658777" ref="tree=MeSH" title="MedGen record for Unresectable Neuroblastoma">Unresectable Neuroblastoma</a></span><ul><li><span class="TLline"><a href="/medgen/79192" ref="tree=MeSH" title="MedGen record for Localized Unresectable Neuroblastoma">Localized Unresectable Neuroblastoma</a></span></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></div></div></div></div>
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Conditions_with_this_feature">Conditions with this feature</h1><a sid="112" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="divPopper rprt" id="rdis_59797"><div><strong>Dubowitz syndrome</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>59797</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0175691</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
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<div class="spaceAbove">Dubowitz syndrome (DS) is a rare multiple congenital syndrome characterized primarly by growth retardation, microcephaly, distinctive facial dysmorphism, cutaneous eczema, a mild to severe intellectual deficit and genital abnormalities.</div>
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<div class="spaceAbove nowrap">See: <a href="/medgen/59797">Condition Record</a></div></div>
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<div class="divPopper rprt" id="rdis_321945"><div><strong>Hereditary thrombocytopenia and hematological cancer predisposition syndrome associated with RUNX1</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>321945</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1832388</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
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<div class="spaceAbove">RUNX1 familial platelet disorder with associated myeloid malignancies (RUNX1-FPDMM) is characterized by prolonged bleeding and/or easy bruising and an increased risk of developing a hematologic malignancy. RUNX1-FPDMM is characterized by thrombocytopenia with normal platelet size; bleeding is often greater than expected due to qualitative platelet dysfunction. Myeloid malignancies are the most common, including acute myelogenous leukemia (and myelodysplastic syndrome. T- and B-cell acute lymphoblastic leukemias and lymphomas have also been reported, as well as skin manifestations (e.g., eczema, psoriasis).</div>
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<div class="spaceAbove nowrap">See: <a href="/medgen/321945">Condition Record</a></div></div>
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<div class="divPopper rprt" id="rdis_372133"><div><strong>Fanconi anemia complementation group N</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>372133</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1835817</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
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<div class="spaceAbove">Fanconi anemia (FA) is characterized by physical abnormalities, bone marrow failure, and increased risk for malignancy. Physical abnormalities, present in approximately 75% of affected individuals, include one or more of the following: short stature, abnormal skin pigmentation, skeletal malformations of the upper and/or lower limbs, microcephaly, and ophthalmic and genitourinary tract anomalies. Progressive bone marrow failure with pancytopenia typically presents in the first decade, often initially with thrombocytopenia or leukopenia. The incidence of acute myeloid leukemia is 13% by age 50 years. Solid tumors – particularly of the head and neck, skin, and genitourinary tract – are more common in individuals with FA.</div>
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<div class="spaceAbove nowrap">See: <a href="/medgen/372133">Condition Record</a></div></div>
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<div class="divPopper rprt" id="rdis_349380"><div><strong>Paragangliomas 4</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>349380</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1861848</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
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<div class="spaceAbove">Hereditary paraganglioma-pheochromocytoma (PGL/PCC) syndromes are characterized by paragangliomas (tumors that arise from neuroendocrine tissues distributed along the paravertebral axis from the base of the skull to the pelvis) and pheochromocytomas (paragangliomas that are confined to the adrenal medulla). Sympathetic paragangliomas cause catecholamine excess; parasympathetic paragangliomas are most often nonsecretory. Extra-adrenal parasympathetic paragangliomas are located predominantly in the skull base and neck (referred to as head and neck paragangliomas [HNPGLs]) and sometimes in the upper mediastinum; approximately 95% of such tumors are nonsecretory. In contrast, extra-adrenal sympathetic paragangliomas are generally confined to the lower mediastinum, abdomen, and pelvis, and are typically secretory. Pheochromocytomas, which arise from the adrenal medulla, typically lead to catecholamine excess. Symptoms of PGL/PCCs result from either mass effects or catecholamine hypersecretion (e.g., sustained or paroxysmal elevations in blood pressure, headache, episodic profuse sweating, forceful palpitations, pallor, and apprehension or anxiety). The risk for developing metastatic disease is greater for extra-adrenal sympathetic paragangliomas than for pheochromocytomas. Additional tumors reported in individuals with hereditary PGL/PCC syndromes include gastrointestinal stromal tumors (GISTs), pulmonary chondromas, and clear cell renal cell carcinoma.</div>
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<div class="spaceAbove nowrap">See: <a href="/medgen/349380">Condition Record</a></div></div>
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<div class="divPopper rprt" id="rdis_401405"><div><strong>Platelet disorder, undefined</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>401405</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1868258</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
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<div class="spaceAbove nowrap">See: <a href="/medgen/401405">Condition Record</a></div></div>
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<div class="divPopper rprt" id="rdis_412713"><div><strong>Neuroblastoma, susceptibility to, 1</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>412713</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C2749485</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Finding</dd></dl></div></div></div>
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<div class="spaceAbove nowrap">See: <a href="/medgen/412713">Condition Record</a></div></div>
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<div class="divPopper rprt" id="rdis_416607"><div><strong>Neuroblastoma, susceptibility to, 2</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>416607</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C2751682</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Finding</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Neuroblastoma occurs most often in children before age 5 and rarely occurs in adults.\n\nIn addition, neuroblastoma tumors can release hormones that may cause other signs and symptoms such as high blood pressure, rapid heartbeat, flushing of the skin, and sweating. In rare instances, individuals with neuroblastoma may develop opsoclonus myoclonus syndrome, which causes rapid eye movements and jerky muscle motions. This condition occurs when the immune system malfunctions and attacks nerve tissue.\n\nIndividuals with neuroblastoma may develop general signs and symptoms such as irritability, fever, tiredness (fatigue), pain, loss of appetite, weight loss, or diarrhea. More specific signs and symptoms depend on the location of the tumor and where it has spread. A tumor in the abdomen can cause abdominal swelling. A tumor in the chest may lead to difficulty breathing. A tumor in the neck can cause nerve damage known as Horner syndrome, which leads to drooping eyelids, small pupils, decreased sweating, and red skin. Tumor metastasis to the bone can cause bone pain, bruises, pale skin, or dark circles around the eyes. Tumors in the backbone can press on the spinal cord and cause weakness, numbness, or paralysis in the arms or legs. A rash of bluish or purplish bumps that look like blueberries indicates that the neuroblastoma has spread to the skin.\n\nNeuroblastoma is a type of cancer that most often affects children. Neuroblastoma occurs when immature nerve cells called neuroblasts become abnormal and multiply uncontrollably to form a tumor. Most commonly, the tumor originates in the nerve tissue of the adrenal gland located above each kidney. Other common sites for tumors to form include the nerve tissue in the abdomen, chest, neck, or pelvis. Neuroblastoma can spread (metastasize) to other parts of the body such as the bones, liver, or skin.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/416607">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_419089"><div><strong>Neurofibromatosis-Noonan syndrome</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>419089</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C2931482</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">A variant of neurofibromatosis type 1 characterized by the combination of features of neurofibromatosis type 1, such as café-au-lait spots, iris Lisch nodules, axillary and inguinal freckling, optic nerve glioma and multiple neurofibromas; and Noonan syndrome, with features such as short stature, typical facial features, congenital heart defects and unusual pectus deformity.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/419089">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_1748029"><div><strong>Mismatch repair cancer syndrome 1</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1748029</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C5399763</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Lynch syndrome is characterized by an increased risk for colorectal cancer (CRC) and cancers of the endometrium, ovary, stomach, small bowel, urinary tract, biliary tract, brain (usually glioblastoma), skin (sebaceous adenomas, sebaceous carcinomas, and keratoacanthomas), pancreas, and prostate. Cancer risks and age of onset vary depending on the associated gene. Several other cancer types have been reported to occur in individuals with Lynch syndrome (e.g., breast, sarcomas, adrenocortical carcinoma). However, the data are not sufficient to demonstrate that the risk of developing these cancers is increased in individuals with Lynch syndrome.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1748029">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_1794285"><div><strong>Central hypoventilation syndrome, congenital, 1, with or without Hirschsprung disease</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1794285</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C5562075</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Congenital central hypoventilation syndrome (CCHS) represents the extreme manifestation of autonomic nervous system dysregulation (ANSD) with the hallmark of disordered respiratory control. The age of initial recognition of CCHS ranges from neonatal onset (i.e., in the first 30 days of life) to (less commonly) later onset (from 1 month to adulthood). Neonatal-onset CCHS is characterized by apparent hypoventilation with monotonous respiratory rates and shallow breathing either during sleep only or while awake as well as asleep; ANSD including decreased heart rate beat-to-beat variability and sinus pauses; altered temperature regulation; and altered pupillary response to light. Some children have altered development of neural crest-derived structures (i.e., Hirschsprung disease, altered esophageal motility/dysphagia, and severe constipation even in the absence of Hirschsprung disease) and/or tumors of neural crest origin (neuroblastoma, ganglioneuroma, and ganglioneuroblastoma). Neurocognitive delay is variable, and possibly influenced by cyanotic breath holding, prolonged sinus pauses, need for 24-hour/day artificial ventilation, and seizures. Later-onset CCHS is characterized by alveolar hypoventilation during sleep and attenuated manifestations of ANSD.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1794285">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_1855924"><div><strong>Megalencephaly-polydactyly syndrome</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1855924</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C5935591</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Megalencephaly-polydactyly syndrome (MPAPA) is an autosomal dominant disorder characterized by megalencephaly, ventriculomegaly, postaxial polydactyly, and, notably, neuroblastoma during infancy (summary by Nishio et al., 2023).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1855924">Condition Record</a></div></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1794285" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Central hypoventilation syndrome, congenital, 1, with or without Hirschsprung disease</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_59797" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Dubowitz syndrome</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_372133" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Fanconi anemia complementation group N</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_321945" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Hereditary thrombocytopenia and hematological cancer predisposition syndrome associated with RUNX1</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1855924" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Megalencephaly-polydactyly syndrome</a></div><div class="jig-moreless" data-jigconfig="class: 'moveDown', moreText: 'See full list (11)', lessText: 'Show less', nodeBefore: 0"><span id="clinMore">
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1748029" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Mismatch repair cancer syndrome 1</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_412713" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Neuroblastoma, susceptibility to, 1</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_416607" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Neuroblastoma, susceptibility to, 2</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_419089" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Neurofibromatosis-Noonan syndrome</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_349380" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Paragangliomas 4</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_401405" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Platelet disorder, undefined</a></div></span></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_105">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Professional_guidelines">Professional guidelines</h1><a sid="105" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">PubMed<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpPM"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/37658764">International Consensus Statement on Allergy and Rhinology: Sinonasal Tumors.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Kuan EC,
|
||
Wang EW,
|
||
Adappa ND,
|
||
Beswick DM,
|
||
London NR Jr,
|
||
Su SY,
|
||
Wang MB,
|
||
Abuzeid WM,
|
||
Alexiev B,
|
||
Alt JA,
|
||
Antognoni P,
|
||
Alonso-Basanta M,
|
||
Batra PS,
|
||
Bhayani M,
|
||
Bell D,
|
||
Bernal-Sprekelsen M,
|
||
Betz CS,
|
||
Blay JY,
|
||
Bleier BS,
|
||
Bonilla-Velez J,
|
||
Callejas C,
|
||
Carrau RL,
|
||
Casiano RR,
|
||
Castelnuovo P,
|
||
Chandra RK,
|
||
Chatzinakis V,
|
||
Chen SB,
|
||
Chiu AG,
|
||
Choby G,
|
||
Chowdhury NI,
|
||
Citardi MJ,
|
||
Cohen MA,
|
||
Dagan R,
|
||
Dalfino G,
|
||
Dallan I,
|
||
Dassi CS,
|
||
de Almeida J,
|
||
Dei Tos AP,
|
||
DelGaudio JM,
|
||
Ebert CS,
|
||
El-Sayed IH,
|
||
Eloy JA,
|
||
Evans JJ,
|
||
Fang CH,
|
||
Farrell NF,
|
||
Ferrari M,
|
||
Fischbein N,
|
||
Folbe A,
|
||
Fokkens WJ,
|
||
Fox MG,
|
||
Lund VJ,
|
||
Gallia GL,
|
||
Gardner PA,
|
||
Geltzeiler M,
|
||
Georgalas C,
|
||
Getz AE,
|
||
Govindaraj S,
|
||
Gray ST,
|
||
Grayson JW,
|
||
Gross BA,
|
||
Grube JG,
|
||
Guo R,
|
||
Ha PK,
|
||
Halderman AA,
|
||
Hanna EY,
|
||
Harvey RJ,
|
||
Hernandez SC,
|
||
Holtzman AL,
|
||
Hopkins C,
|
||
Huang Z,
|
||
Huang Z,
|
||
Humphreys IM,
|
||
Hwang PH,
|
||
Iloreta AM,
|
||
Ishii M,
|
||
Ivan ME,
|
||
Jafari A,
|
||
Kennedy DW,
|
||
Khan M,
|
||
Kimple AJ,
|
||
Kingdom TT,
|
||
Knisely A,
|
||
Kuo YJ,
|
||
Lal D,
|
||
Lamarre ED,
|
||
Lan MY,
|
||
Le H,
|
||
Lechner M,
|
||
Lee NY,
|
||
Lee JK,
|
||
Lee VH,
|
||
Levine CG,
|
||
Lin JC,
|
||
Lin DT,
|
||
Lobo BC,
|
||
Locke T,
|
||
Luong AU,
|
||
Magliocca KR,
|
||
Markovic SN,
|
||
Matnjani G,
|
||
McKean EL,
|
||
Meço C,
|
||
Mendenhall WM,
|
||
Michel L,
|
||
Na'ara S,
|
||
Nicolai P,
|
||
Nuss DW,
|
||
Nyquist GG,
|
||
Oakley GM,
|
||
Omura K,
|
||
Orlandi RR,
|
||
Otori N,
|
||
Papagiannopoulos P,
|
||
Patel ZM,
|
||
Pfister DG,
|
||
Phan J,
|
||
Psaltis AJ,
|
||
Rabinowitz MR,
|
||
Ramanathan M Jr,
|
||
Rimmer R,
|
||
Rosen MR,
|
||
Sanusi O,
|
||
Sargi ZB,
|
||
Schafhausen P,
|
||
Schlosser RJ,
|
||
Sedaghat AR,
|
||
Senior BA,
|
||
Shrivastava R,
|
||
Sindwani R,
|
||
Smith TL,
|
||
Smith KA,
|
||
Snyderman CH,
|
||
Solares CA,
|
||
Sreenath SB,
|
||
Stamm A,
|
||
Stölzel K,
|
||
Sumer B,
|
||
Surda P,
|
||
Tajudeen BA,
|
||
Thompson LDR,
|
||
Thorp BD,
|
||
Tong CCL,
|
||
Tsang RK,
|
||
Turner JH,
|
||
Turri-Zanoni M,
|
||
Udager AM,
|
||
van Zele T,
|
||
VanKoevering K,
|
||
Welch KC,
|
||
Wise SK,
|
||
Witterick IJ,
|
||
Won TB,
|
||
Wong SN,
|
||
Woodworth BA,
|
||
Wormald PJ,
|
||
Yao WC,
|
||
Yeh CF,
|
||
Zhou B,
|
||
Palmer JN</span><br />
|
||
<span class="medgenPMjournal">Int Forum Allergy Rhinol</span>
|
||
2024 Feb;14(2):149-608.
|
||
Epub 2024 Jan 2
|
||
doi: 10.1002/alr.23262.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37658764" target="_blank">37658764</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/35260471">Diagnosis and Management of Opsoclonus-Myoclonus-Ataxia Syndrome in Children: An International Perspective.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Rossor T,
|
||
Yeh EA,
|
||
Khakoo Y,
|
||
Angelini P,
|
||
Hemingway C,
|
||
Irani SR,
|
||
Schleiermacher G,
|
||
Santosh P,
|
||
Lotze T,
|
||
Dale RC,
|
||
Deiva K,
|
||
Hero B,
|
||
Klein A,
|
||
de Alarcon P,
|
||
Gorman MP,
|
||
Mitchell WG,
|
||
Lim M;
|
||
OMS Study Group</span><br />
|
||
<span class="medgenPMjournal">Neurol Neuroimmunol Neuroinflamm</span>
|
||
2022 May;9(3)
|
||
Epub 2022 Mar 8
|
||
doi: 10.1212/NXI.0000000000001153.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35260471" target="_blank">35260471</a><a href="/pmc/articles/PMC8906188" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/33706901">Management of Neuroblastoma in Pediatric Patients.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Croteau N,
|
||
Nuchtern J,
|
||
LaQuaglia MP</span><br />
|
||
<span class="medgenPMjournal">Surg Oncol Clin N Am</span>
|
||
2021 Apr;30(2):291-304.
|
||
Epub 2021 Feb 10
|
||
doi: 10.1016/j.soc.2020.11.010.
|
||
<span class="bold">PMID: </span><a href="/pubmed/33706901" target="_blank">33706901</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(%22neuroblastoma%22%5Btiab%3A~0%5D)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">See all (997)</a></div><h3 class="subhead">Curated<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpCurated"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3><h3 class="nl vspace"><a href="https://www.nccn.org/professionals/physician_gls/pdf/neuroblastoma.pdf" target="_blank">NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®), Neuroblastoma, 2024</a></h3>
|
||
</div>
|
||
</div>
|
||
<div class="display-none help-popup" id="guidelinesHelpPM">These guidelines are articles in PubMed that match specific search criteria developed by MedGen to capture the most relevant practice guidelines. This list may not be comprehensive and may include broader topics as well. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div><div class="display-none help-popup" id="guidelinesHelpCurated">These guidelines are manually curated by the MedGen team
|
||
to supplement articles available in PubMed. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div>
|
||
<div class="portlet mgSection" id="ID_103">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_clinical_studies">Recent clinical studies</h1><a sid="103" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">Etiology</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/35522915">High-Risk and Relapsed Neuroblastoma: Toward More Cures and Better Outcomes.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">DuBois SG,
|
||
Macy ME,
|
||
Henderson TO</span><br />
|
||
<span class="medgenPMjournal">Am Soc Clin Oncol Educ Book</span>
|
||
2022 Apr;42:1-13.
|
||
doi: 10.1200/EDBK_349783.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35522915" target="_blank">35522915</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/34053585">Theranostics in Neuroblastoma.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Rafael MS,
|
||
Cohen-Gogo S,
|
||
Irwin MS,
|
||
Vali R,
|
||
Shammas A,
|
||
Morgenstern DA</span><br />
|
||
<span class="medgenPMjournal">PET Clin</span>
|
||
2021 Jul;16(3):419-427.
|
||
doi: 10.1016/j.cpet.2021.03.006.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34053585" target="_blank">34053585</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/33818884">Neuroblastoma.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Chung C,
|
||
Boterberg T,
|
||
Lucas J,
|
||
Panoff J,
|
||
Valteau-Couanet D,
|
||
Hero B,
|
||
Bagatell R,
|
||
Hill-Kayser CE</span><br />
|
||
<span class="medgenPMjournal">Pediatr Blood Cancer</span>
|
||
2021 May;68 Suppl 2(Suppl 2):e28473.
|
||
doi: 10.1002/pbc.28473.
|
||
<span class="bold">PMID: </span><a href="/pubmed/33818884" target="_blank">33818884</a><a href="/pmc/articles/PMC8785544" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/32726962">Gangliosides and Neuroblastomas.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Schengrund CL</span><br />
|
||
<span class="medgenPMjournal">Int J Mol Sci</span>
|
||
2020 Jul 27;21(15)
|
||
doi: 10.3390/ijms21155313.
|
||
<span class="bold">PMID: </span><a href="/pubmed/32726962" target="_blank">32726962</a><a href="/pmc/articles/PMC7432824" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/17586306">Neuroblastoma.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Maris JM,
|
||
Hogarty MD,
|
||
Bagatell R,
|
||
Cohn SL</span><br />
|
||
<span class="medgenPMjournal">Lancet</span>
|
||
2007 Jun 23;369(9579):2106-20.
|
||
doi: 10.1016/S0140-6736(07)60983-0.
|
||
<span class="bold">PMID: </span><a href="/pubmed/17586306" target="_blank">17586306</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Neuroblastoma%22%20AND%20Etiology%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (7874)</a></div><h3 class="subhead">Diagnosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/36063183">Imaging in neuroblastoma.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Littooij AS,
|
||
de Keizer B</span><br />
|
||
<span class="medgenPMjournal">Pediatr Radiol</span>
|
||
2023 Apr;53(4):783-787.
|
||
Epub 2022 Sep 5
|
||
doi: 10.1007/s00247-022-05489-2.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36063183" target="_blank">36063183</a><a href="/pmc/articles/PMC10027638" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/35522915">High-Risk and Relapsed Neuroblastoma: Toward More Cures and Better Outcomes.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">DuBois SG,
|
||
Macy ME,
|
||
Henderson TO</span><br />
|
||
<span class="medgenPMjournal">Am Soc Clin Oncol Educ Book</span>
|
||
2022 Apr;42:1-13.
|
||
doi: 10.1200/EDBK_349783.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35522915" target="_blank">35522915</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/33139509">Congenital Neuroblastoma.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Minakova E,
|
||
Lang J</span><br />
|
||
<span class="medgenPMjournal">Neoreviews</span>
|
||
2020 Nov;21(11):e716-e727.
|
||
doi: 10.1542/neo.21-11-e716.
|
||
<span class="bold">PMID: </span><a href="/pubmed/33139509" target="_blank">33139509</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/28142287">Overview and recent advances in the treatment of neuroblastoma.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Whittle SB,
|
||
Smith V,
|
||
Doherty E,
|
||
Zhao S,
|
||
McCarty S,
|
||
Zage PE</span><br />
|
||
<span class="medgenPMjournal">Expert Rev Anticancer Ther</span>
|
||
2017 Apr;17(4):369-386.
|
||
Epub 2017 Mar 15
|
||
doi: 10.1080/14737140.2017.1285230.
|
||
<span class="bold">PMID: </span><a href="/pubmed/28142287" target="_blank">28142287</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/21736987">Neuroblastoma.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Colon NC,
|
||
Chung DH</span><br />
|
||
<span class="medgenPMjournal">Adv Pediatr</span>
|
||
2011;58(1):297-311.
|
||
doi: 10.1016/j.yapd.2011.03.011.
|
||
<span class="bold">PMID: </span><a href="/pubmed/21736987" target="_blank">21736987</a><a href="/pmc/articles/PMC3668791" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Neuroblastoma%22%20AND%20Diagnosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (9006)</a></div><h3 class="subhead">Therapy</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/37018492">GD2-CART01 for Relapsed or Refractory High-Risk Neuroblastoma.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Del Bufalo F,
|
||
De Angelis B,
|
||
Caruana I,
|
||
Del Baldo G,
|
||
De Ioris MA,
|
||
Serra A,
|
||
Mastronuzzi A,
|
||
Cefalo MG,
|
||
Pagliara D,
|
||
Amicucci M,
|
||
Li Pira G,
|
||
Leone G,
|
||
Bertaina V,
|
||
Sinibaldi M,
|
||
Di Cecca S,
|
||
Guercio M,
|
||
Abbaszadeh Z,
|
||
Iaffaldano L,
|
||
Gunetti M,
|
||
Iacovelli S,
|
||
Bugianesi R,
|
||
Macchia S,
|
||
Algeri M,
|
||
Merli P,
|
||
Galaverna F,
|
||
Abbas R,
|
||
Garganese MC,
|
||
Villani MF,
|
||
Colafati GS,
|
||
Bonetti F,
|
||
Rabusin M,
|
||
Perruccio K,
|
||
Folsi V,
|
||
Quintarelli C,
|
||
Locatelli F;
|
||
Precision Medicine Team–IRCCS Ospedale Pediatrico Bambino Gesù</span><br />
|
||
<span class="medgenPMjournal">N Engl J Med</span>
|
||
2023 Apr 6;388(14):1284-1295.
|
||
doi: 10.1056/NEJMoa2210859.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37018492" target="_blank">37018492</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/26304901">Advances in Risk Classification and Treatment Strategies for Neuroblastoma.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Pinto NR,
|
||
Applebaum MA,
|
||
Volchenboum SL,
|
||
Matthay KK,
|
||
London WB,
|
||
Ambros PF,
|
||
Nakagawara A,
|
||
Berthold F,
|
||
Schleiermacher G,
|
||
Park JR,
|
||
Valteau-Couanet D,
|
||
Pearson AD,
|
||
Cohn SL</span><br />
|
||
<span class="medgenPMjournal">J Clin Oncol</span>
|
||
2015 Sep 20;33(27):3008-17.
|
||
Epub 2015 Aug 24
|
||
doi: 10.1200/JCO.2014.59.4648.
|
||
<span class="bold">PMID: </span><a href="/pubmed/26304901" target="_blank">26304901</a><a href="/pmc/articles/PMC4567703" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/22056346">I-131-MIBG therapies.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Vöö S,
|
||
Bucerius J,
|
||
Mottaghy FM</span><br />
|
||
<span class="medgenPMjournal">Methods</span>
|
||
2011 Nov;55(3):238-45.
|
||
Epub 2011 Oct 25
|
||
doi: 10.1016/j.ymeth.2011.10.006.
|
||
<span class="bold">PMID: </span><a href="/pubmed/22056346" target="_blank">22056346</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/20879881">Anti-GD2 antibody with GM-CSF, interleukin-2, and isotretinoin for neuroblastoma.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Yu AL,
|
||
Gilman AL,
|
||
Ozkaynak MF,
|
||
London WB,
|
||
Kreissman SG,
|
||
Chen HX,
|
||
Smith M,
|
||
Anderson B,
|
||
Villablanca JG,
|
||
Matthay KK,
|
||
Shimada H,
|
||
Grupp SA,
|
||
Seeger R,
|
||
Reynolds CP,
|
||
Buxton A,
|
||
Reisfeld RA,
|
||
Gillies SD,
|
||
Cohn SL,
|
||
Maris JM,
|
||
Sondel PM;
|
||
Children's Oncology Group</span><br />
|
||
<span class="medgenPMjournal">N Engl J Med</span>
|
||
2010 Sep 30;363(14):1324-34.
|
||
doi: 10.1056/NEJMoa0911123.
|
||
<span class="bold">PMID: </span><a href="/pubmed/20879881" target="_blank">20879881</a><a href="/pmc/articles/PMC3086629" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/9436190">Neuroblastoma: biology and therapy.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Matthay KK</span><br />
|
||
<span class="medgenPMjournal">Oncology (Williston Park)</span>
|
||
1997 Dec;11(12):1857-66; discussion 1869-72, 1875.
|
||
<span class="bold">PMID: </span><a href="/pubmed/9436190" target="_blank">9436190</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Neuroblastoma%22%20AND%20Therapy%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (6116)</a></div><h3 class="subhead">Prognosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/33115626">Pop-corn liver.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Tripathi PR,
|
||
Sen Sarma M,
|
||
Srivastava A</span><br />
|
||
<span class="medgenPMjournal">Dig Liver Dis</span>
|
||
2022 Feb;54(2):282.
|
||
Epub 2020 Oct 26
|
||
doi: 10.1016/j.dld.2020.10.004.
|
||
<span class="bold">PMID: </span><a href="/pubmed/33115626" target="_blank">33115626</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/33382962">Mass screening for neuroblastoma in infants.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Wei M,
|
||
Ye M,
|
||
Dong K,
|
||
Dong R</span><br />
|
||
<span class="medgenPMjournal">Discov Med</span>
|
||
2020 Sep-Oct;30(160):63-70.
|
||
<span class="bold">PMID: </span><a href="/pubmed/33382962" target="_blank">33382962</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/30305231">Update on neuroblastoma.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Newman EA,
|
||
Abdessalam S,
|
||
Aldrink JH,
|
||
Austin M,
|
||
Heaton TE,
|
||
Bruny J,
|
||
Ehrlich P,
|
||
Dasgupta R,
|
||
Baertschiger RM,
|
||
Lautz TB,
|
||
Rhee DS,
|
||
Langham MR Jr,
|
||
Malek MM,
|
||
Meyers RL,
|
||
Nathan JD,
|
||
Weil BR,
|
||
Polites S,
|
||
Madonna MB;
|
||
APSA Cancer committee</span><br />
|
||
<span class="medgenPMjournal">J Pediatr Surg</span>
|
||
2019 Mar;54(3):383-389.
|
||
Epub 2018 Sep 19
|
||
doi: 10.1016/j.jpedsurg.2018.09.004.
|
||
<span class="bold">PMID: </span><a href="/pubmed/30305231" target="_blank">30305231</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/28142287">Overview and recent advances in the treatment of neuroblastoma.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Whittle SB,
|
||
Smith V,
|
||
Doherty E,
|
||
Zhao S,
|
||
McCarty S,
|
||
Zage PE</span><br />
|
||
<span class="medgenPMjournal">Expert Rev Anticancer Ther</span>
|
||
2017 Apr;17(4):369-386.
|
||
Epub 2017 Mar 15
|
||
doi: 10.1080/14737140.2017.1285230.
|
||
<span class="bold">PMID: </span><a href="/pubmed/28142287" target="_blank">28142287</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/10985139">Neuroblastoma.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Alexander F</span><br />
|
||
<span class="medgenPMjournal">Urol Clin North Am</span>
|
||
2000 Aug;27(3):383-92, vii.
|
||
doi: 10.1016/s0094-0143(05)70087-2.
|
||
<span class="bold">PMID: </span><a href="/pubmed/10985139" target="_blank">10985139</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Neuroblastoma%22%20AND%20Prognosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (6978)</a></div><h3 class="subhead">Clinical prediction guides</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/35688160">The immune cell atlas of human neuroblastoma.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Verhoeven BM,
|
||
Mei S,
|
||
Olsen TK,
|
||
Gustafsson K,
|
||
Valind A,
|
||
Lindström A,
|
||
Gisselsson D,
|
||
Fard SS,
|
||
Hagerling C,
|
||
Kharchenko PV,
|
||
Kogner P,
|
||
Johnsen JI,
|
||
Baryawno N</span><br />
|
||
<span class="medgenPMjournal">Cell Rep Med</span>
|
||
2022 Jun 21;3(6):100657.
|
||
Epub 2022 Jun 9
|
||
doi: 10.1016/j.xcrm.2022.100657.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35688160" target="_blank">35688160</a><a href="/pmc/articles/PMC9245004" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/33382963">Role of long noncoding RNA in neuroblastoma.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Ye M,
|
||
Liu B,
|
||
Zhang J,
|
||
Dong K</span><br />
|
||
<span class="medgenPMjournal">Discov Med</span>
|
||
2020 Sep-Oct;30(160):71-82.
|
||
<span class="bold">PMID: </span><a href="/pubmed/33382963" target="_blank">33382963</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/33139509">Congenital Neuroblastoma.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Minakova E,
|
||
Lang J</span><br />
|
||
<span class="medgenPMjournal">Neoreviews</span>
|
||
2020 Nov;21(11):e716-e727.
|
||
doi: 10.1542/neo.21-11-e716.
|
||
<span class="bold">PMID: </span><a href="/pubmed/33139509" target="_blank">33139509</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/26304901">Advances in Risk Classification and Treatment Strategies for Neuroblastoma.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Pinto NR,
|
||
Applebaum MA,
|
||
Volchenboum SL,
|
||
Matthay KK,
|
||
London WB,
|
||
Ambros PF,
|
||
Nakagawara A,
|
||
Berthold F,
|
||
Schleiermacher G,
|
||
Park JR,
|
||
Valteau-Couanet D,
|
||
Pearson AD,
|
||
Cohn SL</span><br />
|
||
<span class="medgenPMjournal">J Clin Oncol</span>
|
||
2015 Sep 20;33(27):3008-17.
|
||
Epub 2015 Aug 24
|
||
doi: 10.1200/JCO.2014.59.4648.
|
||
<span class="bold">PMID: </span><a href="/pubmed/26304901" target="_blank">26304901</a><a href="/pmc/articles/PMC4567703" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/10949776">Cancer screening.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Kramer BS,
|
||
Brawley OW</span><br />
|
||
<span class="medgenPMjournal">Hematol Oncol Clin North Am</span>
|
||
2000 Aug;14(4):831-48.
|
||
doi: 10.1016/s0889-8588(05)70314-2.
|
||
<span class="bold">PMID: </span><a href="/pubmed/10949776" target="_blank">10949776</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Neuroblastoma%22%20AND%20Clinical%20prediction%20guides%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (7870)</a></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_104">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_systematic_reviews">Recent systematic reviews</h1><a sid="104" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln">
|
||
<div class="nl"><a target="_blank" href="/pubmed/36161977">Ophthalmologic Manifestations of Neuroblastoma: A Systemic Review.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Kuchalska K,
|
||
Derwich K,
|
||
Gotz-Więckowska A</span><br />
|
||
<span class="medgenPMjournal">J Pediatr Hematol Oncol</span>
|
||
2023 Mar 1;45(2):47-56.
|
||
Epub 2022 Sep 13
|
||
doi: 10.1097/MPH.0000000000002543.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36161977" target="_blank">36161977</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/35914637">The SH-SY5Y human neuroblastoma cell line, a relevant in vitro cell model for investigating neurotoxicology in human: Focus on organic pollutants.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Lopez-Suarez L,
|
||
Awabdh SA,
|
||
Coumoul X,
|
||
Chauvet C</span><br />
|
||
<span class="medgenPMjournal">Neurotoxicology</span>
|
||
2022 Sep;92:131-155.
|
||
Epub 2022 Jul 29
|
||
doi: 10.1016/j.neuro.2022.07.008.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35914637" target="_blank">35914637</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/35102626">Wogonin and its analogs for the prevention and treatment of cancer: A systematic review.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Banik K,
|
||
Khatoon E,
|
||
Harsha C,
|
||
Rana V,
|
||
Parama D,
|
||
Thakur KK,
|
||
Bishayee A,
|
||
Kunnumakkara AB</span><br />
|
||
<span class="medgenPMjournal">Phytother Res</span>
|
||
2022 May;36(5):1854-1883.
|
||
Epub 2022 Jan 31
|
||
doi: 10.1002/ptr.7386.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35102626" target="_blank">35102626</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/28118852">The SH-SY5Y cell line in Parkinson's disease research: a systematic review.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Xicoy H,
|
||
Wieringa B,
|
||
Martens GJ</span><br />
|
||
<span class="medgenPMjournal">Mol Neurodegener</span>
|
||
2017 Jan 24;12(1):10.
|
||
doi: 10.1186/s13024-017-0149-0.
|
||
<span class="bold">PMID: </span><a href="/pubmed/28118852" target="_blank">28118852</a><a href="/pmc/articles/PMC5259880" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/22325405">Minimally invasive adrenalectomy in children.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Heloury Y,
|
||
Muthucumaru M,
|
||
Panabokke G,
|
||
Cheng W,
|
||
Kimber C,
|
||
Leclair MD</span><br />
|
||
<span class="medgenPMjournal">J Pediatr Surg</span>
|
||
2012 Feb;47(2):415-21.
|
||
doi: 10.1016/j.jpedsurg.2011.08.003.
|
||
<span class="bold">PMID: </span><a href="/pubmed/22325405" target="_blank">22325405</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Neuroblastoma%22%20AND%20systematic%5Bsb%5D%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (117)</a></div></div>
|
||
</div>
|
||
</div></div></div></div></div></div></div>
|
||
<div id="messagearea_bottom">
|
||
|
||
</div>
|
||
<div class=" bottom">
|
||
|
||
</div>
|
||
|
||
</div>
|
||
</div>
|
||
<div class="supplemental col three_col last">
|
||
<h2 class="offscreen_noflow">Supplemental Content</h2>
|
||
|
||
<div>
|
||
|
||
<!-- MedGen supplemental column starts here -->
|
||
<div class="rightCol mgCol">
|
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<div class="portlet mgSection" id="ID_113">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Table_of_contents">Table of contents</h1><a sid="113" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
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<div class="portlet_content ln"><ul id="my-toc"></ul></div>
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</div>
|
||
|
||
<div class="portlet mgSection" id="ID_106">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Genetic_Testing_Registry">Genetic Testing Registry</h1><a sid="106" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><ul><li><a href="/gtr/tests?term=C0027819%5bDISCUI%5d&filter=method%3A2%5F8" target="_blank">Deletion/duplication analysis (21)</a></li>
|
||
<li><a href="/gtr/tests?term=C0027819%5bDISCUI%5d&filter=method%3A2%5F29" target="_blank">Detection of homozygosity (1)</a></li>
|
||
<li><a href="/gtr/tests?term=C0027819%5bDISCUI%5d&filter=method%3A3%5F23" target="_blank">FISH-interphase (1)</a></li>
|
||
<li><a href="/gtr/tests?term=C0027819%5bDISCUI%5d&filter=method%3A3%5F31" target="_blank">Fluorescence in situ hybridization (FISH) (1)</a></li>
|
||
<li><a href="/gtr/tests?term=C0027819%5bDISCUI%5d&filter=method%3A2%5F15" target="_blank">Methylation analysis (3)</a></li>
|
||
<li><a href="/gtr/tests?term=C0027819%5bDISCUI%5d&filter=method%3A2%5F9" target="_blank">Sequence analysis of select exons (3)</a></li>
|
||
<li><a href="/gtr/tests?term=C0027819%5bDISCUI%5d&filter=method%3A2%5F7" target="_blank">Sequence analysis of the entire coding region (24)</a></li>
|
||
<li><a href="/gtr/tests?term=C0027819%5bDISCUI%5d&filter=method%3A2%5F19" target="_blank">Targeted variant analysis (4)</a></li>
|
||
<li class="portletSeeAll portletSeeAllPad"><total><a href="/gtr/tests?term=C0027819%5bDISCUI%5d" target="_blank">See all (33)</a></total></li>
|
||
</ul></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_119">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Clinical_resources">Clinical resources</h1><a sid="119" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><ul><li><a href="http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Expert=635" target="_blank">Orphanet</a></li><li><a href="https://clinicaltrials.gov/search?cond=Neuroblastoma" target="_blank">ClinicalTrials.gov</a></li></ul></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_121">
|
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Practice_guidelines">Practice guidelines</h1><a sid="121" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><ul class="a_poppers"><li><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(%22neuroblastoma%22%5Btiab%3A~0%5D)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">PubMed</a><div class="help-popup">See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div></li><li><a target="_blank" href="/books/?term=((%22clinical%20guidelines%22%5BResource%20Type%5D)%20OR%20%22practice%20guideline%22%5BPublication%20Type%5D)%20AND%20(%22Neuroblastoma%22)">Bookshelf</a><div class="help-popup">See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div></li></ul><h3 class="subhead">Curated</h3><ul class="a_poppers"><li><a target="_blank" href="https://www.nccn.org/professionals/physician_gls/pdf/neuroblastoma.pdf">NCCN, 2024</a><div>NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®), Neuroblastoma, 2024</div></li></ul></div>
|
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|
||
<div class="portlet mgSection" id="ID_116">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Consumer_resources">Consumer resources</h1><a sid="116" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><ul><li><a href="http://www.diseaseinfosearch.org/Neuroblastoma/5160" target="_blank">Genetic Alliance</a></li><li><a href="https://www.malacards.org/card/neuroblastoma_1" target="_blank">MalaCards</a></li><li><a href="https://vsearch.nlm.nih.gov/vivisimo/cgi-bin/query-meta?v:project=medlineplus&query=Neuroblastoma" target="_blank">MedlinePlus</a></li><li><a href="https://rarediseases.info.nih.gov/diseases/7185/disease" target="_blank">NCATS Office of Rare Diseases Research (GARD)</a></li></ul></div>
|
||
</div>
|
||
</div>
|
||
<div class="portlet brieflink">
|
||
<div class="portlet_head">
|
||
<div class="portlet_title">
|
||
<h3>Reviews</h3>
|
||
</div>
|
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<a name="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_SingleItemSuplCluster.MedGenReviews.Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="Reviews" id="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_SingleItemSuplCluster.MedGenReviews.Shutter"></a>
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<div class="portlet_content">
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<ul>
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<li>
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||
<a href="/pubmed/20301782" ref="ncbi_uid=&discoId=gtr_reviews&linkpos=1&linkpostotal=3" target="_blank"><span class="gene_reviews">GeneReviews</span></a>
|
||
</li>
|
||
<li>
|
||
<a href="/pubmed/clinical?term=Neuroblastoma" ref="ncbi_uid=&discoId=gtr_reviews&linkpos=2&linkpostotal=3" target="_blank">PubMed Clinical Queries</a>
|
||
</li>
|
||
<li>
|
||
<a href="/pubmed?term=Neuroblastoma%20AND%20humans[mesh]%20AND%20review[publication%20type]" ref="ncbi_uid=&discoId=gtr_reviews&linkpos=3&linkpostotal=3" target="_blank">Reviews in PubMed</a>
|
||
</li>
|
||
</ul>
|
||
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|
||
</div>
|
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|
||
<!-- MedGen supplemental column ends here -->
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<div class="portlet brieflink">
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<div class="portlet_head">
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<div class="portlet_title">
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<h3>Related information</h3>
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<div class="portlet_content DiscoveryDbLinks">
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<ul>
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<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/clinvar?LinkName=medgen_clinvar&from_uid=18012" ref="log$=recordlinks">ClinVar</a>
|
||
<div class="brieflinkpop offscreen_noflow">Related medical variations</div>
|
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</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/gtr/tests?term=C0027819[DISCUI]" ref="log$=recordlinks">GTR</a>
|
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<div class="brieflinkpop offscreen_noflow">Related information in GTR</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/gtr/tests?term=C0027819[DISCUI]&test_type=Clinical" ref="log$=recordlinks">GTR(Clinical)</a>
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<div class="brieflinkpop offscreen_noflow">Clinical tests in GTR</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
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||
<a class="brieflinkpopperctrl" href="/mesh?LinkName=medgen_mesh&from_uid=18012" ref="log$=recordlinks">MeSH</a>
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<div class="brieflinkpop offscreen_noflow">Related Medical Subject Headings</div>
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</li>
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<li class="brieflinkpopper">
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||
<a class="brieflinkpopperctrl" href="/books?LinkName=medgen_books&from_uid=18012" ref="log$=recordlinks">NCBI Bookshelf</a>
|
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<div class="brieflinkpop offscreen_noflow">Related information in NCBI Bookshelf</div>
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</li>
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||
<li class="brieflinkpopper">
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<a href="https://www.google.com/maps/place/8600+Rockville+Pike,+Bethesda,+MD+20894/@38.9959508,-77.101021,17z/data=!3m1!4b1!4m5!3m4!1s0x89b7c95e25765ddb:0x19156f88b27635b8!8m2!3d38.9959508!4d-77.0988323" class="text-white" target="_blank" rel="noopener noreferrer">8600 Rockville Pike<br />
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Bethesda, MD 20894</a></p>
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<p><a href="https://www.nlm.nih.gov/web_policies.html" class="text-white">Web Policies</a><br />
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<p><a class="supportLink text-white" href="https://support.nlm.nih.gov/">Help</a><br />
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