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<meta name="keywords" content="C0020517, allergic disease, allergic disease or disorder, allergic disorders, allergic form of disease or disorder, allergic form of immune system disease, allergic hypersensitivity disease, allergic reaction, allergic response, allergies, allergy, disorder of type i hypersensitivity, hypersensitive, hypersensitivities, hypersensitivity, hypersensitivity reaction, hypersensitivity reaction type i disease, pathologic function, sensitivity, type i hypersensitivity disease, autosomal dominant, autosomal recessive, birth defects, chromosomal disease, chromosome, clinical features, clinical findings, clinical genetics, clinical recommendations, clinvar, congenital chromosomal disease, consumer genetic resources, cytogenetic location, disease characteristics, disease definitions, disease descriptions, disease ontology, disease synonyms, disease vocabulary, dysmorphology, entrez, familial disease, gene, gene-disease relationship, genereviews, genetic disease, genetic disorder, genetic terminology, genetic testing registry, genetics home reference, genomic disease, gtr, hereditary disease, heritable disease, hpo, human phenotype ontology, inherited disease, management guidelines, maternal inheritance, medgen, medical genetics, medical subject headings, mesh, mitochondrial inheritance, mode of inheritance, national center for biotechnology information, national institutes of health, national library of medicine, ncbi, nih, nlm, omim, ordo, orphanet, paternal inheritance, phenome, position statements, professional practice guidelines, rare disease, reference sequence, refseq, snomed ct, syndrome, undiagnosed diseases, x-linked recessive" /><meta name="description" content="An allergy is an immune response or reaction to substances that are usually not harmful." /><meta name="robots" content="index,nofollow,noarchive" />
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<!--
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UID=9370
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ConceptID=C0020517
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-->
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<!--imgCountBooks = 0--><h1 class="medgenTitle"><div class="MedGenTitleText">Allergy</div></h1><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>9370</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information."><span class="highlight" style="background-color:">C0020517</span></a></dd><dt><span class="dotprefix"> •</span></dt><dd>Pathologic Function</dd></dl></div></div><table class="medgenTable"><tbody><tr><td>Synonyms:</td>
|
||
<td>Allergies; Hypersensitivities; Hypersensitivity</td></tr>
|
||
<tr><td><span class="bold">SNOMED CT: </span></td>
|
||
<td>Hypersensitivity reaction (421961002)</td></tr>
|
||
<tr><td colspan="2" class="small"> </td></tr><tr><td>HPO:</td>
|
||
<td><a target="_blank" title="Human Phenotype Ontology" href="https://hpo.jax.org/app/browse/term/HP:0012393">HP:0012393</a></td></tr>
|
||
<tr><td>Monarch Initiative:</td>
|
||
<td><a href="https://monarchinitiative.org/disease/MONDO:0005271" target="_blank">MONDO:0005271</a></td></tr>
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<div class="portlet_content ln">An allergy is an immune response or reaction to substances that are usually not harmful. [from <a title="Human Phenotype Ontology" href="http://www.human-phenotype-ontology.org" class="defSource" target="_blank">HPO</a>]</div>
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<div class="portlet mgSection" id="ID_118">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Term_Hierarchy">Term Hierarchy</h1><a sid="118" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="portlet_content ln HierarchyGTR"><div class="jig-ncbitabs"><ul><li><a href="#tabGTR">GTR</a></li><li><a href="#tabMGEN">MeSH</a></li></ul><div id="tabGTR"><div class="search_result"><div class="rprts"><div class="chiclet_legend"><span class="chiclet_list" style="position:static;"><span title="Clinical test" class="chiclet Ccolor round">C</span><span>Clinical test, </span><span title="Research test" class="chiclet Rcolor round">R</span><span>Research test, </span><span title="OMIM" class="chiclet Ocolor ">O</span><span>OMIM, </span><span title="GeneReview" class="chiclet Gcolor">G</span><span><em>GeneReviews</em>, </span><span title="ClinVar" class="chiclet Vcolor">V</span><span>ClinVar </span></span></div><div id="hierarchy" class="margin_t1"><div class="ds_tree"><ul><li class="matched_ds"><span class="TLline">Allergy</span></li></ul></div></div></div></div></div><div id="tabMGEN"><div class="ds_tree"><ul><li><span class="TLline"><a href="/medgen/21047" ref="tree=MeSH" title="MedGen record for Pathological Conditions, Signs and Symptoms">Pathological Conditions, Signs and Symptoms</a></span><ul><li><span class="TLline"><a href="/medgen/18325" ref="tree=MeSH" title="MedGen record for Pathological process">Pathological process</a></span><ul><li><span class="TLline"><a href="/medgen/4347" ref="tree=MeSH" title="MedGen record for Disease">Disease</a></span><ul><li><span class="TLline"><a href="/medgen/232130" ref="tree=MeSH" title="MedGen record for Disorder by Site">Disorder by Site</a></span><ul><li><span class="TLline"><a href="/medgen/232638" ref="tree=MeSH" title="MedGen record for Immune System and Related Disorders">Immune System and Related Disorders</a></span><ul><li><span class="TLline"><a href="/medgen/5759" ref="tree=MeSH" title="MedGen record for Immune system disorder">Immune system disorder</a></span><ul><li><span class="matched_ds">Allergy</span><ul><li><span class="TLline"><a href="/medgen/3590" ref="tree=MeSH" title="MedGen record for Allergic conjunctivitis">Allergic conjunctivitis</a></span><ul><li><span class="TLline"><a href="/medgen/1316" ref="tree=MeSH" title="MedGen record for Angelucci syndrome">Angelucci syndrome</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/287129" ref="tree=MeSH" title="MedGen record for Allergic reaction">Allergic reaction</a></span><ul><li><span class="TLline"><a href="/medgen/42064" ref="tree=MeSH" title="MedGen record for Allergy to food">Allergy to food</a></span><ul><li><span class="TLline"><a href="/medgen/672822" ref="tree=MeSH" title="MedGen record for Allergy to fruit">Allergy to fruit</a></span></li><li><span class="TLline"><a href="/medgen/661135" ref="tree=MeSH" title="MedGen record for Allergy to shellfish">Allergy to shellfish</a></span></li><li><span class="TLline"><a href="/medgen/181859" ref="tree=MeSH" title="MedGen record for Allergy to wheat">Allergy to wheat</a></span></li><li><span class="TLline"><a href="/medgen/86965" ref="tree=MeSH" title="MedGen record for Allergy, Milk">Allergy, Milk</a></span></li><li><span class="TLline"><a href="/medgen/1786053" ref="tree=MeSH" title="MedGen record for Dairy or Lactose Intolerance Allergy">Dairy or Lactose Intolerance Allergy</a></span></li><li><span class="TLline"><a href="/medgen/108241" ref="tree=MeSH" title="MedGen record for Egg allergy">Egg allergy</a></span></li><li><span class="TLline"><a href="/medgen/844468" ref="tree=MeSH" title="MedGen record for Meat allergen allergy">Meat allergen allergy</a></span></li><li><span class="TLline"><a href="/medgen/1393851" ref="tree=MeSH" title="MedGen record for Nut and Peanut Hypersensitivity">Nut and Peanut Hypersensitivity</a></span></li><li><span class="TLline"><a href="/medgen/108401" ref="tree=MeSH" title="MedGen record for Nut food product allergy">Nut food product allergy</a></span></li><li><span class="TLline"><a href="/medgen/1779582" ref="tree=MeSH" title="MedGen record for Processed Food Allergy">Processed Food Allergy</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/904400" ref="tree=MeSH" title="MedGen record for Animal protein allergy">Animal protein allergy</a></span><ul><li><span class="TLline"><a href="/medgen/742044" ref="tree=MeSH" title="MedGen record for Allergy to bee venom">Allergy to bee venom</a></span></li><li><span class="TLline"><a href="/medgen/573353" ref="tree=MeSH" title="MedGen record for Allergy to domestic cat protein">Allergy to domestic cat protein</a></span></li><li><span class="TLline"><a href="/medgen/740925" ref="tree=MeSH" title="MedGen record for Allergy to wasp venom">Allergy to wasp venom</a></span></li><li><span class="TLline"><a href="/medgen/675148" ref="tree=MeSH" title="MedGen record for Animal dander allergy">Animal dander allergy</a></span></li><li><span class="TLline"><a href="/medgen/196633" ref="tree=MeSH" title="MedGen record for Dog Allergy">Dog Allergy</a></span></li><li><span class="TLline"><a href="/medgen/1768805" ref="tree=MeSH" title="MedGen record for Venomous Ant Bite Allergy">Venomous Ant Bite Allergy</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/1776563" ref="tree=MeSH" title="MedGen record for Mold or Dust Allergy">Mold or Dust Allergy</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/382012" ref="tree=MeSH" title="MedGen record for Allergic rhinitis">Allergic rhinitis</a></span><ul><li><span class="TLline"><a href="/medgen/1417" ref="tree=MeSH" title="MedGen record for Atopic Rhinitis">Atopic Rhinitis</a></span></li><li><span class="TLline"><a href="/medgen/19783" ref="tree=MeSH" title="MedGen record for Perennial allergic rhinitis">Perennial allergic rhinitis</a></span></li><li><span class="TLline"><a href="/medgen/42335" ref="tree=MeSH" title="MedGen record for Seasonal allergy">Seasonal allergy</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/737992" ref="tree=MeSH" title="MedGen record for Alpha-gal allergy">Alpha-gal allergy</a></span></li><li><span class="TLline"><a href="/medgen/1902" ref="tree=MeSH" title="MedGen record for Anaphylaxis">Anaphylaxis</a></span></li><li><span class="TLline"><a href="/medgen/871595" ref="tree=MeSH" title="MedGen record for Asthma-chronic obstructive pulmonary disease overlap syndrome">Asthma-chronic obstructive pulmonary disease overlap syndrome</a></span></li><li><span class="TLline"><a href="/medgen/1692510" ref="tree=MeSH" title="MedGen record for Bacteria allergy">Bacteria allergy</a></span></li><li><span class="TLline"><a href="/medgen/102380" ref="tree=MeSH" title="MedGen record for Contact hypersensitivity">Contact hypersensitivity</a></span></li><li><span class="TLline"><a href="/medgen/41663" ref="tree=MeSH" title="MedGen record for Drug allergy">Drug allergy</a></span><ul><li><span class="TLline"><a href="/medgen/230819" ref="tree=MeSH" title="MedGen record for Aspirin-induced asthma">Aspirin-induced asthma</a></span></li><li><span class="TLline"><a href="/medgen/8328" ref="tree=MeSH" title="MedGen record for Eruption caused by drug">Eruption caused by drug</a></span><ul><li><span class="TLline"><a href="/medgen/209091" ref="tree=MeSH" title="MedGen record for Acute generalized exanthematous pustulosis">Acute generalized exanthematous pustulosis</a></span></li><li><span class="TLline"><a href="/medgen/762193" ref="tree=MeSH" title="MedGen record for Drug rash with eosinophilia and systemic symptoms">Drug rash with eosinophilia and systemic symptoms</a></span></li><li><span class="TLline"><a href="/medgen/41858" ref="tree=MeSH" title="MedGen record for Erythema nodosum">Erythema nodosum</a></span></li><li><span class="TLline"><a href="/medgen/107497" ref="tree=MeSH" title="MedGen record for Hand-foot syndrome">Hand-foot syndrome</a></span></li><li><span class="TLline"><a href="/medgen/810780" ref="tree=MeSH" title="MedGen record for Nicolau syndrome">Nicolau syndrome</a></span></li><li><span class="TLline"><a href="/medgen/11390" ref="tree=MeSH" title="MedGen record for Serum sickness">Serum sickness</a></span></li><li><span class="TLline"><a href="/medgen/20955" ref="tree=MeSH" title="MedGen record for Stevens-Johnson syndrome">Stevens-Johnson syndrome</a></span></li></ul></li></ul></li><li><span class="TLline"><a href="/medgen/573356" ref="tree=MeSH" title="MedGen record for Dust mite allergy">Dust mite allergy</a></span></li><li><span class="TLline"><a href="/medgen/84383" ref="tree=MeSH" title="MedGen record for Environmental allergy">Environmental allergy</a></span><ul><li><span class="TLline"><a href="/medgen/116716" ref="tree=MeSH" title="MedGen record for Idiopathic environmental intolerance">Idiopathic environmental intolerance</a></span></li><li><span class="TLline"><a href="/medgen/48661" ref="tree=MeSH" title="MedGen record for Sick building syndrome">Sick building syndrome</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/573354" ref="tree=MeSH" title="MedGen record for Feather allergy">Feather allergy</a></span></li><li><span class="TLline"><a href="/medgen/1635115" ref="tree=MeSH" title="MedGen record for Food allergy">Food allergy</a></span><ul><li><span class="TLline"><a href="/medgen/1705383" ref="tree=MeSH" title="MedGen record for Dairy allergy">Dairy allergy</a></span><ul><li><span class="TLline"><a href="/medgen/1668719" ref="tree=MeSH" title="MedGen record for Cow milk allergy">Cow milk allergy</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/1698538" ref="tree=MeSH" title="MedGen record for Gluten allergy">Gluten allergy</a></span></li><li><span class="TLline"><a href="/medgen/1700974" ref="tree=MeSH" title="MedGen record for Plant based food allergy">Plant based food allergy</a></span></li><li><span class="TLline"><a href="/medgen/672821" ref="tree=MeSH" title="MedGen record for Seafood allergy">Seafood allergy</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/843732" ref="tree=MeSH" title="MedGen record for Fungi allergy">Fungi allergy</a></span></li><li><span class="TLline"><a href="/medgen/810927" ref="tree=MeSH" title="MedGen record for Hypersensitivity reaction mediated by antibody">Hypersensitivity reaction mediated by antibody</a></span></li><li><span class="TLline"><a href="/medgen/549647" ref="tree=MeSH" title="MedGen record for Hypersensitivity reaction mediated by immune complex">Hypersensitivity reaction mediated by immune complex</a></span></li><li><span class="TLline"><a href="/medgen/43785" ref="tree=MeSH" title="MedGen record for IgE-mediated allergic disorder">IgE-mediated allergic disorder</a></span><ul><li><span class="TLline"><a href="/medgen/11196" ref="tree=MeSH" title="MedGen record for Airway hyperresponsiveness">Airway hyperresponsiveness</a></span><ul><li><span class="TLline"><a href="/medgen/2109" ref="tree=MeSH" title="MedGen record for Asthma">Asthma</a></span></li><li><span class="TLline"><a href="/medgen/1446" ref="tree=MeSH" title="MedGen record for Hypersensitivity pneumonitis">Hypersensitivity pneumonitis</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/2458" ref="tree=MeSH" title="MedGen record for Arthus reaction">Arthus reaction</a></span></li><li><span class="TLline"><a href="/medgen/41502" ref="tree=MeSH" title="MedGen record for Atopic eczema">Atopic eczema</a></span><ul><li><span class="TLline"><a href="/medgen/350353" ref="tree=MeSH" title="MedGen record for Dermatitis, atopic">Dermatitis, atopic</a></span></li><li><span class="TLline"><a href="/medgen/340100" ref="tree=MeSH" title="MedGen record for Dermatitis, atopic, 2">Dermatitis, atopic, 2</a></span></li><li><span class="TLline"><a href="/medgen/344173" ref="tree=MeSH" title="MedGen record for Dermatitis, atopic, 3">Dermatitis, atopic, 3</a></span></li><li><span class="TLline"><a href="/medgen/340099" ref="tree=MeSH" title="MedGen record for Dermatitis, atopic, 4">Dermatitis, atopic, 4</a></span></li><li><span class="TLline"><a href="/medgen/381292" ref="tree=MeSH" title="MedGen record for Dermatitis, atopic, 5">Dermatitis, atopic, 5</a></span></li><li><span class="TLline"><a href="/medgen/344154" ref="tree=MeSH" title="MedGen record for Dermatitis, atopic, 6">Dermatitis, atopic, 6</a></span></li><li><span class="TLline"><a href="/medgen/414058" ref="tree=MeSH" title="MedGen record for Dermatitis, atopic, 7">Dermatitis, atopic, 7</a></span></li><li><span class="TLline"><a href="/medgen/462113" ref="tree=MeSH" title="MedGen record for Dermatitis, atopic, 8">Dermatitis, atopic, 8</a></span></li><li><span class="TLline"><a href="/medgen/462114" ref="tree=MeSH" title="MedGen record for Dermatitis, atopic, 9">Dermatitis, atopic, 9</a></span></li><li><span class="TLline"><a href="/medgen/870398" ref="tree=MeSH" title="MedGen record for Late onset atopic dermatitis">Late onset atopic dermatitis</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/83318" ref="tree=MeSH" title="MedGen record for Eosinophilic esophagitis">Eosinophilic esophagitis</a></span><ul><li><span class="TLline"><a href="/medgen/1052360" ref="tree=MeSH" title="MedGen record for Childhood eosinophilic esophagitis">Childhood eosinophilic esophagitis</a></span></li><li><span class="TLline"><a href="/medgen/1634032" ref="tree=MeSH" title="MedGen record for Esophagitis, eosinophilic, 1">Esophagitis, eosinophilic, 1</a></span></li><li><span class="TLline"><a href="/medgen/462029" ref="tree=MeSH" title="MedGen record for Esophagitis, eosinophilic, 2">Esophagitis, eosinophilic, 2</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/22587" ref="tree=MeSH" title="MedGen record for Urticaria">Urticaria</a></span><ul><li><span class="TLline"><a href="/medgen/1543" ref="tree=MeSH" title="MedGen record for Angioedema">Angioedema</a></span></li><li><span class="TLline"><a href="/medgen/662267" ref="tree=MeSH" title="MedGen record for Chronic idiopathic urticaria">Chronic idiopathic urticaria</a></span></li><li><span class="TLline"><a href="/medgen/537829" ref="tree=MeSH" title="MedGen record for Chronic urticaria">Chronic urticaria</a></span></li><li><span class="TLline"><a href="/medgen/909963" ref="tree=MeSH" title="MedGen record for Darier sign">Darier sign</a></span></li><li><span class="TLline"><a href="/medgen/1773749" ref="tree=MeSH" title="MedGen record for Neutrophilic urticarial dermatosis">Neutrophilic urticarial dermatosis</a></span></li><li><span class="TLline"><a href="/medgen/1639813" ref="tree=MeSH" title="MedGen record for Physical urticaria">Physical urticaria</a></span></li></ul></li></ul></li><li><span class="TLline"><a href="/medgen/1695966" ref="tree=MeSH" title="MedGen record for Insect allergy">Insect allergy</a></span><ul><li><span class="TLline"><a href="/medgen/687869" ref="tree=MeSH" title="MedGen record for Insect bite allergy">Insect bite allergy</a></span></li><li><span class="TLline"><a href="/medgen/1387536" ref="tree=MeSH" title="MedGen record for Venom allergy">Venom allergy</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/868518" ref="tree=MeSH" title="MedGen record for Iodine contrast allergy">Iodine contrast allergy</a></span></li><li><span class="TLline"><a href="/medgen/1380779" ref="tree=MeSH" title="MedGen record for Kounis Syndrome">Kounis Syndrome</a></span></li><li><span class="TLline"><a href="/medgen/107909" ref="tree=MeSH" title="MedGen record for Latex allergy">Latex allergy</a></span></li><li><span class="TLline"><a href="/medgen/1670935" ref="tree=MeSH" title="MedGen record for Parasite allergy">Parasite allergy</a></span></li><li><span class="TLline"><a href="/medgen/1691178" ref="tree=MeSH" title="MedGen record for Plant product allergy">Plant product allergy</a></span></li><li><span class="TLline"><a href="/medgen/7021" ref="tree=MeSH" title="MedGen record for Type III hypersensitivity disease">Type III hypersensitivity disease</a></span><ul><li><span class="TLline"><a href="/medgen/57718" ref="tree=MeSH" title="MedGen record for Allergic cutaneous vasculitis">Allergic cutaneous vasculitis</a></span></li><li><span class="TLline"><a href="/medgen/48265" ref="tree=MeSH" title="MedGen record for Immunoglobulin A vasculitis">Immunoglobulin A vasculitis</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/9371" ref="tree=MeSH" title="MedGen record for Type IV hypersensitivity disease">Type IV hypersensitivity disease</a></span><ul><li><span class="TLline"><a href="/medgen/102474" ref="tree=MeSH" title="MedGen record for Allergic contact dermatitis">Allergic contact dermatitis</a></span><ul><li><span class="TLline"><a href="/medgen/56514" ref="tree=MeSH" title="MedGen record for Photoallergic dermatitis">Photoallergic dermatitis</a></span></li><li><span class="TLline"><a href="/medgen/10820" ref="tree=MeSH" title="MedGen record for Toxicodendron dermatitis">Toxicodendron dermatitis</a></span></li></ul></li></ul></li><li><span class="TLline"><a href="/medgen/53087" ref="tree=MeSH" title="MedGen record for Wissler syndrome">Wissler syndrome</a></span></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></div></div></div></div>
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Conditions_with_this_feature">Conditions with this feature</h1><a sid="112" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="divPopper rprt" id="rdis_346801"><div><strong>Pyogenic arthritis-pyoderma gangrenosum-acne syndrome</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>346801</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1858361</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
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<div class="spaceAbove">Pyogenic sterile arthritis, pyoderma gangrenosum, and acne (PAPA) is a rare autosomal dominant autoinflammatory disease that typically presents with recurrent sterile, erosive arthritis in childhood, occurring spontaneously or after minor trauma, occasionally resulting in significant joint destruction. By puberty, joint symptoms tend to subside and cutaneous symptoms predominate, including pathergy, frequently with abscesses at the sites of injections, severe cystic acne, and recurrent nonhealing sterile ulcers, often diagnosed as pyoderma gangrenosum (summary by Demidowich et al., 2012).</div>
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<div class="spaceAbove nowrap">See: <a href="/medgen/346801">Condition Record</a></div></div>
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<div class="divPopper rprt" id="rdis_350144"><div><strong>Hereditary papulotranslucent acrokeratoderma</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>350144</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1863343</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
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<div class="spaceAbove">A keratosis of the hands and feet characterized by persistent, asymptomatic, yellowish to white papules and plaques associated with fine-textured scalp hair and an atopic diathesis.</div>
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<div class="spaceAbove nowrap">See: <a href="/medgen/350144">Condition Record</a></div></div>
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<div class="divPopper rprt" id="rdis_422452"><div><strong>Bardet-Biedl syndrome 1</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>422452</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C2936862</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
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<div class="spaceAbove">Bardet-Biedl syndrome is an autosomal recessive and genetically heterogeneous ciliopathy characterized by retinitis pigmentosa, obesity, kidney dysfunction, polydactyly, behavioral dysfunction, and hypogonadism (summary by Beales et al., 1999). Eight proteins implicated in the disorder assemble to form the BBSome, a stable complex involved in signaling receptor trafficking to and from cilia (summary by Scheidecker et al., 2014). Genetic Heterogeneity of Bardet-Biedl Syndrome BBS2 (615981) is caused by mutation in a gene on 16q13 (606151); BBS3 (600151), by mutation in the ARL6 gene on 3q11 (608845); BBS4 (615982), by mutation in a gene on 15q22 (600374); BBS5 (615983), by mutation in a gene on 2q31 (603650); BBS6 (605231), by mutation in the MKKS gene on 20p12 (604896); BBS7 (615984), by mutation in a gene on 4q27 (607590); BBS8 (615985), by mutation in the TTC8 gene on 14q32 (608132); BBS9 (615986), by mutation in a gene on 7p14 (607968); BBS10 (615987), by mutation in a gene on 12q21 (610148); BBS11 (615988), by mutation in the TRIM32 gene on 9q33 (602290); BBS12 (615989), by mutation in a gene on 4q27 (610683); BBS13 (615990), by mutation in the MKS1 gene (609883) on 17q23; BBS14 (615991), by mutation in the CEP290 gene (610142) on 12q21, BBS15 (615992), by mutation in the WDPCP gene (613580) on 2p15; BBS16 (615993), by mutation in the SDCCAG8 gene (613524) on 1q43; BBS17 (615994), by mutation in the LZTFL1 gene (606568) on 3p21; BBS18 (615995), by mutation in the BBIP1 gene (613605) on 10q25; BBS19 (615996), by mutation in the IFT27 gene (615870) on 22q12; BBS20 (619471), by mutation in the IFT172 gene (607386) on 9p21; BBS21 (617406), by mutation in the CFAP418 gene (614477) on 8q22; and BBS22 (617119), by mutation in the IFT74 gene (608040) on 9p21. The CCDC28B gene (610162) modifies the expression of BBS phenotypes in patients who have mutations in other genes. Mutations in MKS1, MKS3 (TMEM67; 609884), and C2ORF86 also modify the expression of BBS phenotypes in patients who have mutations in other genes. Although BBS had originally been thought to be a recessive disorder, Katsanis et al. (2001) demonstrated that clinical manifestation of some forms of Bardet-Biedl syndrome requires recessive mutations in 1 of the 6 loci plus an additional mutation in a second locus. While Katsanis et al. (2001) called this 'triallelic inheritance,' Burghes et al. (2001) suggested the term 'recessive inheritance with a modifier of penetrance.' Mykytyn et al. (2002) found no evidence of involvement of the common BBS1 mutation in triallelic inheritance. However, Fan et al. (2004) found heterozygosity in a mutation of the BBS3 gene (608845.0002) as an apparent modifier of the expression of homozygosity of the met390-to-arg mutation in the BBS1 gene (209901.0001). Allelic disorders include nonsyndromic forms of retinitis pigmentosa: RP51 (613464), caused by TTC8 mutation, and RP55 (613575), caused by ARL6 mutation.</div>
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<div class="spaceAbove nowrap">See: <a href="/medgen/422452">Condition Record</a></div></div>
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<div class="divPopper rprt" id="rdis_482544"><div><strong>Familial cold autoinflammatory syndrome 3</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>482544</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C3280914</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
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<div class="spaceAbove">Familial cold autoinflammatory syndrome-3 is an autosomal dominant immune disorder characterized by the development of cutaneous urticaria, erythema, and pruritus in response to cold exposure. Affected individuals have variable additional immunologic defects, including antibody deficiency, decreased numbers of B cells, defective B cells, increased susceptibility to infection, and increased risk of autoimmune disorders (summary by Ombrello et al., 2012). For a discussion of genetic heterogeneity of FCAS, see FCAS1 (120100).</div>
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<div class="spaceAbove nowrap">See: <a href="/medgen/482544">Condition Record</a></div></div>
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<div class="divPopper rprt" id="rdis_863651"><div><strong>Autoimmune lymphoproliferative syndrome due to CTLA4 haploinsufficiency</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>863651</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C4015214</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
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<div class="spaceAbove">Immune dysregulation with autoimmunity, immunodeficiency, and lymphoproliferation (IDAIL) is an autosomal dominant complex immune disorder with highly variable presentation and clinical manifestations. Prominent features include recurrent infections often associated with hypogammaglobulinemia, autoimmune features such as autoimmune cytopenias, and abnormal lymphocytic infiltration of nonlymphoid organs, including the lungs, brain, and gastrointestinal tract, resulting in enteropathy. Laboratory studies often show lymphopenia and abnormal T and B cell subsets. The variable features are a result of impaired function of Treg cells, which play a role in immune homeostasis (summary by Kuehn et al., 2014; Schwab et al., 2018, and Lopez-Nevado et al., 2021). The disorder shows overlapping features with autoimmune lymphoproliferative syndrome (ALPS); for a general description and a discussion of genetic heterogeneity of ALPS, see 601859.</div>
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<div class="spaceAbove nowrap">See: <a href="/medgen/863651">Condition Record</a></div></div>
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<div class="divPopper rprt" id="rdis_1794167"><div><strong>Developmental delay, impaired speech, and behavioral abnormalities</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1794167</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C5561957</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
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<div class="spaceAbove">Developmental delay, impaired speech, and behavioral abnormalities (DDISBA) is characterized by global developmental delay apparent from early childhood. Intellectual disability can range from mild to severe. Additional variable features may include dysmorphic facial features, seizures, hypotonia, motor abnormalities such as Tourette syndrome or dystonia, and hearing loss (summary by Cousin et al., 2021).</div>
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<div class="spaceAbove nowrap">See: <a href="/medgen/1794167">Condition Record</a></div></div>
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<div class="divPopper rprt" id="rdis_1794251"><div><strong>Loeys-Dietz syndrome 6</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1794251</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C5562041</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
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<div class="spaceAbove">Loeys-Dietz syndrome (LDS) is characterized by vascular findings (cerebral, thoracic, and abdominal arterial aneurysms and/or dissections), skeletal manifestations (pectus excavatum or pectus carinatum, scoliosis, joint laxity, arachnodactyly, talipes equinovarus, and cervical spine malformation and/or instability), craniofacial features (hypertelorism, strabismus, bifid uvula / cleft palate, and craniosynostosis that can involve any sutures), and cutaneous findings (velvety and translucent skin, easy bruising, and dystrophic scars). Individuals with LDS are predisposed to widespread and aggressive arterial aneurysms and pregnancy-related complications including uterine rupture and death. Individuals with LDS can show a strong predisposition for allergic/inflammatory disease including asthma, eczema, and reactions to food or environmental allergens. There is also an increased incidence of gastrointestinal inflammation including eosinophilic esophagitis and gastritis or inflammatory bowel disease. Wide variation in the distribution and severity of clinical features can be seen in individuals with LDS, even among affected individuals within a family who have the same pathogenic variant.</div>
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<div class="spaceAbove nowrap">See: <a href="/medgen/1794251">Condition Record</a></div></div>
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<div class="divPopper rprt" id="rdis_1841075"><div><strong>Hatipoglu immunodeficiency syndrome</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1841075</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C5830439</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
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<div class="spaceAbove">Hatipoglu immunodeficiency syndrome (HATIS) is an autosomal recessive immunologic disorder characterized by childhood onset of failure to thrive, skin manifestations, pancytopenia, and susceptibility to recurrent infections (Harapas et al., 2022).</div>
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<div class="spaceAbove nowrap">See: <a href="/medgen/1841075">Condition Record</a></div></div>
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<div class="divPopper rprt" id="rdis_1854360"><div><strong>Jeffries-Lakhani neurodevelopmental syndrome</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1854360</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C5935596</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
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<div class="spaceAbove">Jeffries-Lakhani neurodevelopmental syndrome (JELANS) is an autosomal recessive disorder characterized by hypotonia, early-onset seizures, and global developmental delay apparent from infancy. Affected individuals have motor delay, speech delay, and impaired intellectual development, and about half of patients are nonambulatory and/or nonverbal. Some patients have cardiac arrhythmia, but congenital cardiac septal defects are only rarely observed. Additional features may include feeding difficulties, recurrent infections, ocular defects, and nonspecific dysmorphic features. Premature death due to cardiac arrhythmia or epilepsy may occur (Jeffries et al., 2024).</div>
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<div class="spaceAbove nowrap">See: <a href="/medgen/1854360">Condition Record</a></div></div>
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<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_863651" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Autoimmune lymphoproliferative syndrome due to CTLA4 haploinsufficiency</a></div>
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<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_422452" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Bardet-Biedl syndrome 1</a></div>
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<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1794167" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Developmental delay, impaired speech, and behavioral abnormalities</a></div>
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<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_482544" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Familial cold autoinflammatory syndrome 3</a></div>
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<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1841075" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Hatipoglu immunodeficiency syndrome</a></div><div class="jig-moreless" data-jigconfig="class: 'moveDown', moreText: 'See full list (9)', lessText: 'Show less', nodeBefore: 0"><span id="clinMore">
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_350144" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Hereditary papulotranslucent acrokeratoderma</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1854360" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Jeffries-Lakhani neurodevelopmental syndrome</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1794251" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Loeys-Dietz syndrome 6</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_346801" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Pyogenic arthritis-pyoderma gangrenosum-acne syndrome</a></div></span></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_105">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Professional_guidelines">Professional guidelines</h1><a sid="105" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">PubMed<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpPM"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/36878860">International consensus statement on allergy and rhinology: Allergic rhinitis - 2023.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Wise SK,
|
||
Damask C,
|
||
Roland LT,
|
||
Ebert C,
|
||
Levy JM,
|
||
Lin S,
|
||
Luong A,
|
||
Rodriguez K,
|
||
Sedaghat AR,
|
||
Toskala E,
|
||
Villwock J,
|
||
Abdullah B,
|
||
Akdis C,
|
||
Alt JA,
|
||
Ansotegui IJ,
|
||
Azar A,
|
||
Baroody F,
|
||
Benninger MS,
|
||
Bernstein J,
|
||
Brook C,
|
||
Campbell R,
|
||
Casale T,
|
||
Chaaban MR,
|
||
Chew FT,
|
||
Chambliss J,
|
||
Cianferoni A,
|
||
Custovic A,
|
||
Davis EM,
|
||
DelGaudio JM,
|
||
Ellis AK,
|
||
Flanagan C,
|
||
Fokkens WJ,
|
||
Franzese C,
|
||
Greenhawt M,
|
||
Gill A,
|
||
Halderman A,
|
||
Hohlfeld JM,
|
||
Incorvaia C,
|
||
Joe SA,
|
||
Joshi S,
|
||
Kuruvilla ME,
|
||
Kim J,
|
||
Klein AM,
|
||
Krouse HJ,
|
||
Kuan EC,
|
||
Lang D,
|
||
Larenas-Linnemann D,
|
||
Laury AM,
|
||
Lechner M,
|
||
Lee SE,
|
||
Lee VS,
|
||
Loftus P,
|
||
Marcus S,
|
||
Marzouk H,
|
||
Mattos J,
|
||
McCoul E,
|
||
Melen E,
|
||
Mims JW,
|
||
Mullol J,
|
||
Nayak JV,
|
||
Oppenheimer J,
|
||
Orlandi RR,
|
||
Phillips K,
|
||
Platt M,
|
||
Ramanathan M Jr,
|
||
Raymond M,
|
||
Rhee CS,
|
||
Reitsma S,
|
||
Ryan M,
|
||
Sastre J,
|
||
Schlosser RJ,
|
||
Schuman TA,
|
||
Shaker MS,
|
||
Sheikh A,
|
||
Smith KA,
|
||
Soyka MB,
|
||
Takashima M,
|
||
Tang M,
|
||
Tantilipikorn P,
|
||
Taw MB,
|
||
Tversky J,
|
||
Tyler MA,
|
||
Veling MC,
|
||
Wallace D,
|
||
Wang Y,
|
||
White A,
|
||
Zhang L</span><br />
|
||
<span class="medgenPMjournal">Int Forum Allergy Rhinol</span>
|
||
2023 Apr;13(4):293-859.
|
||
Epub 2023 Mar 6
|
||
doi: 10.1002/alr.23090.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36878860" target="_blank">36878860</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/36122788">Drug allergy: A 2022 practice parameter update.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Khan DA,
|
||
Banerji A,
|
||
Blumenthal KG,
|
||
Phillips EJ,
|
||
Solensky R,
|
||
White AA,
|
||
Bernstein JA,
|
||
Chu DK,
|
||
Ellis AK,
|
||
Golden DBK,
|
||
Greenhawt MJ,
|
||
Horner CC,
|
||
Ledford D,
|
||
Lieberman JA,
|
||
Oppenheimer J,
|
||
Rank MA,
|
||
Shaker MS,
|
||
Stukus DR,
|
||
Wallace D,
|
||
Wang J;
|
||
Chief Editor(s):,
|
||
Khan DA,
|
||
Golden DBK,
|
||
Shaker M,
|
||
Stukus DR;
|
||
Workgroup Contributors:,
|
||
Khan DA,
|
||
Banerji A,
|
||
Blumenthal KG,
|
||
Phillips EJ,
|
||
Solensky R,
|
||
White AA;
|
||
Joint Task Force on Practice Parameters Reviewers:,
|
||
Bernstein JA,
|
||
Chu DK,
|
||
Ellis AK,
|
||
Golden DBK,
|
||
Greenhawt MJ,
|
||
Horner CC,
|
||
Ledford D,
|
||
Lieberman JA,
|
||
Oppenheimer J,
|
||
Rank MA,
|
||
Shaker MS,
|
||
Stukus DR,
|
||
Wallace D,
|
||
Wang J</span><br />
|
||
<span class="medgenPMjournal">J Allergy Clin Immunol</span>
|
||
2022 Dec;150(6):1333-1393.
|
||
Epub 2022 Sep 17
|
||
doi: 10.1016/j.jaci.2022.08.028.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36122788" target="_blank">36122788</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/32707227">Rhinitis 2020: A practice parameter update.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Dykewicz MS,
|
||
Wallace DV,
|
||
Amrol DJ,
|
||
Baroody FM,
|
||
Bernstein JA,
|
||
Craig TJ,
|
||
Dinakar C,
|
||
Ellis AK,
|
||
Finegold I,
|
||
Golden DBK,
|
||
Greenhawt MJ,
|
||
Hagan JB,
|
||
Horner CC,
|
||
Khan DA,
|
||
Lang DM,
|
||
Larenas-Linnemann DES,
|
||
Lieberman JA,
|
||
Meltzer EO,
|
||
Oppenheimer JJ,
|
||
Rank MA,
|
||
Shaker MS,
|
||
Shaw JL,
|
||
Steven GC,
|
||
Stukus DR,
|
||
Wang J;
|
||
Chief Editor(s):,
|
||
Dykewicz MS,
|
||
Wallace DV;
|
||
Joint Task Force on Practice Parameters:,
|
||
Dinakar C,
|
||
Ellis AK,
|
||
Golden DBK,
|
||
Greenhawt MJ,
|
||
Horner CC,
|
||
Khan DA,
|
||
Lang DM,
|
||
Lieberman JA,
|
||
Oppenheimer JJ,
|
||
Rank MA,
|
||
Shaker MS,
|
||
Stukus DR,
|
||
Wang J;
|
||
Workgroup Contributors:,
|
||
Dykewicz MS,
|
||
Wallace DV,
|
||
Amrol DJ,
|
||
Baroody FM,
|
||
Bernstein JA,
|
||
Craig TJ,
|
||
Finegold I,
|
||
Hagan JB,
|
||
Larenas-Linnemann DES,
|
||
Meltzer EO,
|
||
Shaw JL,
|
||
Steven GC</span><br />
|
||
<span class="medgenPMjournal">J Allergy Clin Immunol</span>
|
||
2020 Oct;146(4):721-767.
|
||
Epub 2020 Jul 22
|
||
doi: 10.1016/j.jaci.2020.07.007.
|
||
<span class="bold">PMID: </span><a href="/pubmed/32707227" target="_blank">32707227</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(%22allergy%22%5Btiab%3A~0%5D)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">See all (3190)</a></div></div>
|
||
</div>
|
||
<div class="display-none help-popup" id="guidelinesHelpPM">These guidelines are articles in PubMed that match specific search criteria developed by MedGen to capture the most relevant practice guidelines. This list may not be comprehensive and may include broader topics as well. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div><div class="display-none help-popup" id="guidelinesHelpCurated">These guidelines are manually curated by the MedGen team
|
||
to supplement articles available in PubMed. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div>
|
||
<div class="portlet mgSection" id="ID_103">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_clinical_studies">Recent clinical studies</h1><a sid="103" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">Etiology</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/36871575">Prevention of food allergy in infancy: the role of maternal interventions and exposures during pregnancy and lactation.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Abrams EM,
|
||
Shaker MS,
|
||
Chan ES,
|
||
Brough HA,
|
||
Greenhawt M</span><br />
|
||
<span class="medgenPMjournal">Lancet Child Adolesc Health</span>
|
||
2023 May;7(5):358-366.
|
||
Epub 2023 Mar 2
|
||
doi: 10.1016/S2352-4642(22)00349-2.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36871575" target="_blank">36871575</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/33370488">Update on food allergy.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Peters RL,
|
||
Krawiec M,
|
||
Koplin JJ,
|
||
Santos AF</span><br />
|
||
<span class="medgenPMjournal">Pediatr Allergy Immunol</span>
|
||
2021 May;32(4):647-657.
|
||
Epub 2021 Jan 21
|
||
doi: 10.1111/pai.13443.
|
||
<span class="bold">PMID: </span><a href="/pubmed/33370488" target="_blank">33370488</a><a href="/pmc/articles/PMC8247869" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/32499034">Food Allergy from Infancy Through Adulthood.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Sicherer SH,
|
||
Warren CM,
|
||
Dant C,
|
||
Gupta RS,
|
||
Nadeau KC</span><br />
|
||
<span class="medgenPMjournal">J Allergy Clin Immunol Pract</span>
|
||
2020 Jun;8(6):1854-1864.
|
||
doi: 10.1016/j.jaip.2020.02.010.
|
||
<span class="bold">PMID: </span><a href="/pubmed/32499034" target="_blank">32499034</a><a href="/pmc/articles/PMC7899184" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/25017679">Vaccine allergy.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Caubet JC,
|
||
Ponvert C</span><br />
|
||
<span class="medgenPMjournal">Immunol Allergy Clin North Am</span>
|
||
2014 Aug;34(3):597-613, ix.
|
||
doi: 10.1016/j.iac.2014.04.004.
|
||
<span class="bold">PMID: </span><a href="/pubmed/25017679" target="_blank">25017679</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/25017674">Antibiotic allergy.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Romano A,
|
||
Warrington R</span><br />
|
||
<span class="medgenPMjournal">Immunol Allergy Clin North Am</span>
|
||
2014 Aug;34(3):489-506, vii.
|
||
Epub 2014 May 27
|
||
doi: 10.1016/j.iac.2014.03.003.
|
||
<span class="bold">PMID: </span><a href="/pubmed/25017674" target="_blank">25017674</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Allergy%22%20AND%20Etiology%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (67664)</a></div><h3 class="subhead">Diagnosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/36122788">Drug allergy: A 2022 practice parameter update.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Khan DA,
|
||
Banerji A,
|
||
Blumenthal KG,
|
||
Phillips EJ,
|
||
Solensky R,
|
||
White AA,
|
||
Bernstein JA,
|
||
Chu DK,
|
||
Ellis AK,
|
||
Golden DBK,
|
||
Greenhawt MJ,
|
||
Horner CC,
|
||
Ledford D,
|
||
Lieberman JA,
|
||
Oppenheimer J,
|
||
Rank MA,
|
||
Shaker MS,
|
||
Stukus DR,
|
||
Wallace D,
|
||
Wang J;
|
||
Chief Editor(s):,
|
||
Khan DA,
|
||
Golden DBK,
|
||
Shaker M,
|
||
Stukus DR;
|
||
Workgroup Contributors:,
|
||
Khan DA,
|
||
Banerji A,
|
||
Blumenthal KG,
|
||
Phillips EJ,
|
||
Solensky R,
|
||
White AA;
|
||
Joint Task Force on Practice Parameters Reviewers:,
|
||
Bernstein JA,
|
||
Chu DK,
|
||
Ellis AK,
|
||
Golden DBK,
|
||
Greenhawt MJ,
|
||
Horner CC,
|
||
Ledford D,
|
||
Lieberman JA,
|
||
Oppenheimer J,
|
||
Rank MA,
|
||
Shaker MS,
|
||
Stukus DR,
|
||
Wallace D,
|
||
Wang J</span><br />
|
||
<span class="medgenPMjournal">J Allergy Clin Immunol</span>
|
||
2022 Dec;150(6):1333-1393.
|
||
Epub 2022 Sep 17
|
||
doi: 10.1016/j.jaci.2022.08.028.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36122788" target="_blank">36122788</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/34875122">Food allergy and hypersensitivity reactions in children and adults-A review.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Tedner SG,
|
||
Asarnoj A,
|
||
Thulin H,
|
||
Westman M,
|
||
Konradsen JR,
|
||
Nilsson C</span><br />
|
||
<span class="medgenPMjournal">J Intern Med</span>
|
||
2022 Mar;291(3):283-302.
|
||
Epub 2021 Dec 22
|
||
doi: 10.1111/joim.13422.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34875122" target="_blank">34875122</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/32499034">Food Allergy from Infancy Through Adulthood.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Sicherer SH,
|
||
Warren CM,
|
||
Dant C,
|
||
Gupta RS,
|
||
Nadeau KC</span><br />
|
||
<span class="medgenPMjournal">J Allergy Clin Immunol Pract</span>
|
||
2020 Jun;8(6):1854-1864.
|
||
doi: 10.1016/j.jaip.2020.02.010.
|
||
<span class="bold">PMID: </span><a href="/pubmed/32499034" target="_blank">32499034</a><a href="/pmc/articles/PMC7899184" target="_blank" class="PubMedFree">Free PMC Article</a></div>
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<div class="nl"><a target="_blank" href="/pubmed/25017674">Antibiotic allergy.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Romano A,
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<span class="bold">PMID: </span><a href="/pubmed/25017674" target="_blank">25017674</a></div>
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<div class="nl"><a target="_blank" href="/pubmed/24388012">Food allergy: Epidemiology, pathogenesis, diagnosis, and treatment.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Sicherer SH,
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<div class="nl"><a target="_blank" href="/pubmed/31287523">Effect of Recombinant Zoster Vaccine on Incidence of Herpes Zoster After Autologous Stem Cell Transplantation: A Randomized Clinical Trial.</a></div>
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<div class="nl"><a target="_blank" href="/pubmed/14673247">Latex allergy.</a></div>
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<div class="nl"><a target="_blank" href="/pubmed/14713908">Development of the asthma control test: a survey for assessing asthma control.</a></div>
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</div>
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<div class="portlet mgSection" id="ID_104">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_systematic_reviews">Recent systematic reviews</h1><a sid="104" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="portlet_content ln">
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<div class="nl"><a target="_blank" href="/pubmed/37678577">Systemic treatments for atopic dermatitis (eczema): Systematic review and network meta-analysis of randomized trials.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Chu AWL,
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Wong MM,
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Rayner DG,
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Guyatt GH,
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Díaz Martinez JP,
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Ceccacci R,
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Zhao IX,
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McMullen E,
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Srivastava A,
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Wang J,
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Wen A,
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Wang FC,
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Brignardello-Petersen R,
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Izcovich A,
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Oykhman P,
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Wheeler KE,
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Wang J,
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Spergel JM,
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Singh JA,
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Silverberg JI,
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Ong PY,
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O'Brien M,
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Martin SA,
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Lio PA,
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Lind ML,
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LeBovidge J,
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Kim E,
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Huynh J,
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Greenhawt M,
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Gardner DD,
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Frazier WT,
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Ellison K,
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Chen L,
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Capozza K,
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De Benedetto A,
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Boguniewicz M,
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Smith Begolka W,
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Asiniwasis RN,
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Schneider LC,
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<span class="bold">PMID: </span><a href="/pubmed/37678577" target="_blank">37678577</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Chu DK,
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Chu AWL,
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Chu X,
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Islam N,
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Gao Y,
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Izcovich A,
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Asiniwasis RN,
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Boguniewicz M,
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De Benedetto A,
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Capozza K,
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Chen L,
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Ellison K,
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Frazier WT,
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Greenhawt M,
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Huynh J,
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LeBovidge J,
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Lio PA,
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Martin SA,
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O'Brien M,
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Ong PY,
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Silverberg JI,
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Spergel JM,
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Smith Begolka W,
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Wang J,
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Wheeler KE,
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Gardner DD,
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Schneider L</span><br />
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<span class="bold">PMID: </span><a href="/pubmed/37678572" target="_blank">37678572</a></div>
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<div class="nl"><a target="_blank" href="/pubmed/36529441">Omalizumab in IgE-Mediated Food Allergy: A Systematic Review and Meta-Analysis.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Zuberbier T,
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Wood RA,
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Bindslev-Jensen C,
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Fiocchi A,
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Chinthrajah RS,
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Worm M,
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Deschildre A,
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Fernandez-Rivas M,
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Santos AF,
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Jaumont X,
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Tassinari P</span><br />
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<span class="medgenPMjournal">J Allergy Clin Immunol Pract</span>
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2023 Apr;11(4):1134-1146.
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<span class="bold">PMID: </span><a href="/pubmed/36529441" target="_blank">36529441</a></div>
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<div class="nl"><a target="_blank" href="/pubmed/32001253">Anaphylaxis-a 2020 practice parameter update, systematic review, and Grading of Recommendations, Assessment, Development and Evaluation (GRADE) analysis.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Shaker MS,
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Wallace DV,
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Golden DBK,
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Oppenheimer J,
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Bernstein JA,
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Khan DA,
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Lang DM,
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Lang ES,
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Lieberman JA,
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Portnoy J,
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Rank MA,
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Stukus DR,
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Wang J;
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Collaborators,
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Riblet N,
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Bobrownicki AMP,
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Bontrager T,
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Dusin J,
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Foley J,
|
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Frederick B,
|
||
Fregene E,
|
||
Hellerstedt S,
|
||
Hassan F,
|
||
Hess K,
|
||
Horner C,
|
||
Huntington K,
|
||
Kasireddy P,
|
||
Keeler D,
|
||
Kim B,
|
||
Lieberman P,
|
||
Lindhorst E,
|
||
McEnany F,
|
||
Milbank J,
|
||
Murphy H,
|
||
Pando O,
|
||
Patel AK,
|
||
Ratliff N,
|
||
Rhodes R,
|
||
Robertson K,
|
||
Scott H,
|
||
Snell A,
|
||
Sullivan R,
|
||
Trivedi V,
|
||
Wickham A;
|
||
Chief Editors,
|
||
Shaker MS,
|
||
Wallace DV;
|
||
Workgroup Contributors,
|
||
Shaker MS,
|
||
Wallace DV,
|
||
Bernstein JA,
|
||
Campbell RL,
|
||
Dinakar C,
|
||
Ellis A,
|
||
Golden DBK,
|
||
Greenhawt M,
|
||
Lieberman JA,
|
||
Rank MA,
|
||
Stukus DR,
|
||
Wang J;
|
||
Joint Task Force on Practice Parameters Reviewers,
|
||
Shaker MS,
|
||
Wallace DV,
|
||
Golden DBK,
|
||
Bernstein JA,
|
||
Dinakar C,
|
||
Ellis A,
|
||
Greenhawt M,
|
||
Horner C,
|
||
Khan DA,
|
||
Lieberman JA,
|
||
Oppenheimer J,
|
||
Rank MA,
|
||
Shaker MS,
|
||
Stukus DR,
|
||
Wang J</span><br />
|
||
<span class="medgenPMjournal">J Allergy Clin Immunol</span>
|
||
2020 Apr;145(4):1082-1123.
|
||
Epub 2020 Jan 28
|
||
doi: 10.1016/j.jaci.2020.01.017.
|
||
<span class="bold">PMID: </span><a href="/pubmed/32001253" target="_blank">32001253</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/28884986">Corticosteroids in management of anaphylaxis; a systematic review of evidence.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Liyanage CK,
|
||
Galappatthy P,
|
||
Seneviratne SL</span><br />
|
||
<span class="medgenPMjournal">Eur Ann Allergy Clin Immunol</span>
|
||
2017 Sep;49(5):196-207.
|
||
doi: 10.23822/EurAnnACI.1764-1489.15.
|
||
<span class="bold">PMID: </span><a href="/pubmed/28884986" target="_blank">28884986</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Allergy%22%20AND%20systematic%5Bsb%5D%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (2406)</a></div></div>
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<h2 class="offscreen_noflow">Supplemental Content</h2>
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<div class="portlet_content ln"><ul class="a_poppers"><li><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(%22allergy%22%5Btiab%3A~0%5D)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">PubMed</a><div class="help-popup">See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div></li><li><a target="_blank" href="/books/?term=((%22clinical%20guidelines%22%5BResource%20Type%5D)%20OR%20%22practice%20guideline%22%5BPublication%20Type%5D)%20AND%20(%22Allergy%22)">Bookshelf</a><div class="help-popup">See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div></li></ul></div>
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