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<meta name="keywords" content="C0019061, acute renal failure, thrombocytopenia, and microangiopathic hemolytic anaemia associated with distorted erythrocytes ('burr cells'), acute renal failure, thrombocytopenia, and microangiopathic hemolytic anemia associated with distorted erythrocytes ('burr cells'), disease or syndrome, gasser syndrome, gasser's syndrome, gassers syndrome, haemolytic-uraemic syndrome, hemolytic uremic syndrome, hemolytic-uremic syndrome, hus, hus - hemolytic uremic syndrome, syndrome, hemolytic-uremic, autosomal dominant, autosomal recessive, birth defects, chromosomal disease, chromosome, clinical features, clinical findings, clinical genetics, clinical recommendations, clinvar, congenital chromosomal disease, consumer genetic resources, cytogenetic location, disease characteristics, disease definitions, disease descriptions, disease ontology, disease synonyms, disease vocabulary, dysmorphology, entrez, familial disease, gene, gene-disease relationship, genereviews, genetic disease, genetic disorder, genetic terminology, genetic testing registry, genetics home reference, genomic disease, gtr, hereditary disease, heritable disease, hpo, human phenotype ontology, inherited disease, management guidelines, maternal inheritance, medgen, medical genetics, medical subject headings, mesh, mitochondrial inheritance, mode of inheritance, national center for biotechnology information, national institutes of health, national library of medicine, ncbi, nih, nlm, omim, ordo, orphanet, paternal inheritance, phenome, position statements, professional practice guidelines, rare disease, reference sequence, refseq, snomed ct, syndrome, undiagnosed diseases, x-linked recessive" /><meta name="description" content="A thrombotic microangiopathy with presence of non-immune, intravascular hemolytic anemia, thrombocytopenia and acute kidney injury. A vicious cycle of complement activation, endothelial cell damage, platelet activation, and thrombosis is the hallmark of the disease." /><meta name="robots" content="index,nofollow,noarchive" />
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<!--
|
||
UID=42403
|
||
ConceptID=C0019061
|
||
-->
|
||
<!--imgCountBooks = 0--><h1 class="medgenTitle"><div class="MedGenTitleText">Hemolytic-uremic syndrome<span class="h1sub">(HUS)</span></div></h1><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>42403</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information."><span class="highlight" style="background-color:">C0019061</span></a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div><table class="medgenTable"><tbody><tr><td>Synonyms:</td>
|
||
<td>Acute renal failure, thrombocytopenia, and microangiopathic hemolytic anemia associated with distorted erythrocytes ('burr cells'); HUS</td></tr>
|
||
<tr><td><span class="bold">SNOMED CT: </span></td>
|
||
<td>HUS - Hemolytic uremic syndrome (111407006); Hemolytic uremic syndrome (111407006); Gasser's syndrome (111407006)</td></tr>
|
||
<tr><td colspan="2" class="small"> </td></tr><tr><td><a class="help" data-jig="ncbipopper" href="#target-gene-related">Related genes:<img src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a><div id="target-gene-related" class="display-none">
|
||
Gene(s) associated with related conditions. For conditions<br />
|
||
in a hierarchy, the parent condition will list the genes<br />
|
||
associated with the children conditions.</div></td>
|
||
<td><a target="_blank" href="/gene/10878">CFHR3</a>, <a target="_blank" href="/gene/10877">CFHR4</a>, <a target="_blank" href="/gene/7056">THBD</a>, <a target="_blank" href="/gene/4179">CD46</a>, <a target="_blank" href="/gene/3426">CFI</a>, <a target="_blank" href="/gene/3078">CFHR1</a>, <a target="_blank" href="/gene/3075">CFH</a>, <a target="_blank" href="/gene/718">C3</a>, <a target="_blank" href="/gene/629">CFB</a></td></tr><tr><td colspan="2" class="small"> </td></tr><tr><td>HPO:</td>
|
||
<td><a target="_blank" title="Human Phenotype Ontology" href="https://hpo.jax.org/app/browse/term/HP:0005575">HP:0005575</a></td></tr>
|
||
<tr><td>Monarch Initiative:</td>
|
||
<td><a href="https://monarchinitiative.org/disease/MONDO:0001549" target="_blank">MONDO:0001549</a></td></tr>
|
||
<tr><td>Orphanet:</td>
|
||
<td><a target="_blank" title="Orphanet: The portal for rare diseases and orphan drugs" href="http://www.orpha.net/consor/cgi-bin/OC_Exp.php?lng=EN&Expert=544458">ORPHA544458</a></td></tr></tbody></table></div><div class="rprt-body jig-ncbiinpagenav" data-jigconfig="smoothScroll: false, gotoTopLink: true, gotoTopLinkText: '', gotoTopLinkAttrs: {'title': 'Go to the top of the page'},allHeadingLevels: ['h1'], topOfPageTOC: true, tocId: 'my-toc'"><div id="rprt-tabs-1" class="rprt-tab"><div id="tb-termsProp-1"><div class="leftCol mgCol"><div>
|
||
<div class="portlet mgSection" id="ID_100">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Definition">Definition</h1><a sid="100" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln">A thrombotic microangiopathy with presence of non-immune, intravascular hemolytic anemia, thrombocytopenia and acute kidney injury. A vicious cycle of complement activation, endothelial cell damage, platelet activation, and thrombosis is the hallmark of the disease. [from <a title="Human Phenotype Ontology" href="http://www.human-phenotype-ontology.org" class="defSource" target="_blank">HPO</a>]</div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_118">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Term_Hierarchy">Term Hierarchy</h1><a sid="118" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln HierarchyGTR"><div class="jig-ncbitabs"><ul><li><a href="#tabGTR">GTR</a></li><li><a href="#tabMGEN">MeSH</a></li></ul><div id="tabGTR"><div class="search_result"><div class="rprts"><div class="chiclet_legend"><span class="chiclet_list" style="position:static;"><span title="Clinical test" class="chiclet Ccolor round">C</span><span>Clinical test, </span><span title="Research test" class="chiclet Rcolor round">R</span><span>Research test, </span><span title="OMIM" class="chiclet Ocolor ">O</span><span>OMIM, </span><span title="GeneReview" class="chiclet Gcolor">G</span><span><em>GeneReviews</em>, </span><span title="ClinVar" class="chiclet Vcolor">V</span><span>ClinVar </span></span></div><div id="hierarchy" class="margin_t1"><div class="ds_tree"><ul><li class="matched_ds"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C0019061[DISCUI]&test_type=Clinical" ref="ncbi_uid=42403">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet unavailable" title="OMIM">O</span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&from_uid=42403" ref="ncbi_uid=42403">V</a></span></span><span class="TLline">Hemolytic-uremic syndrome</span><ul><li class="TLclosed"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C2931788[DISCUI]&test_type=Clinical" ref="ncbi_uid=444141">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet unavailable" title="OMIM">O</span><span class="chiclet Gcolor" title="GeneReviews"><a target="_blank" href="/books/NBK1367/" ref="ncbi_uid=444141">G</a></span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&from_uid=444141" ref="ncbi_uid=444141">V</a></span></span><span class="TLline"><a href="/medgen/444141" ref="tree=GTR&ncbi_uid=444141&link_uid=444141" title="View MedGen record for 'Atypical hemolytic-uremic syndrome'">Atypical hemolytic-uremic syndrome</a></span><ul><li class="TLclosed"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C2752038[DISCUI]&test_type=Clinical" ref="ncbi_uid=416691">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet Ocolor" title="OMIM"><a ref="ncbi_uid=416691" target="_blank" href="/omim/138470">O</a></span><span class="chiclet Gcolor" title="GeneReviews"><a target="_blank" href="/books/NBK1367/" ref="ncbi_uid=416691">G</a></span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&from_uid=416691" ref="ncbi_uid=416691">V</a></span></span><span class="TLline"><a href="/medgen/416691" ref="tree=GTR&ncbi_uid=416691&link_uid=416691" title="View MedGen record for 'Atypical hemolytic-uremic syndrome with B factor anomaly'">Atypical hemolytic-uremic syndrome with B factor anomaly</a></span></li><li class="TLclosed"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C2752037[DISCUI]&test_type=Clinical" ref="ncbi_uid=442875">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet Ocolor" title="OMIM"><a ref="ncbi_uid=442875" target="_blank" href="/omim/120700">O</a></span><span class="chiclet Gcolor" title="GeneReviews"><a target="_blank" href="/books/NBK1367/" ref="ncbi_uid=442875">G</a></span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&from_uid=442875" ref="ncbi_uid=442875">V</a></span></span><span class="TLline"><a href="/medgen/442875" ref="tree=GTR&ncbi_uid=442875&link_uid=442875" title="View MedGen record for 'Atypical hemolytic-uremic syndrome with C3 anomaly'">Atypical hemolytic-uremic syndrome with C3 anomaly</a></span></li><li class="TLclosed"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C2752039[DISCUI]&test_type=Clinical" ref="ncbi_uid=414542">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet Ocolor" title="OMIM"><a ref="ncbi_uid=414542" target="_blank" href="/omim/217030">O</a></span><span class="chiclet Gcolor" title="GeneReviews"><a target="_blank" href="/books/NBK1367/" ref="ncbi_uid=414542">G</a></span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&from_uid=414542" ref="ncbi_uid=414542">V</a></span></span><span class="TLline"><a href="/medgen/414542" ref="tree=GTR&ncbi_uid=414542&link_uid=414542" title="View MedGen record for 'Atypical hemolytic-uremic syndrome with I factor anomaly'">Atypical hemolytic-uremic syndrome with I factor anomaly</a></span></li><li class="TLclosed"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C2752040[DISCUI]&test_type=Clinical" ref="ncbi_uid=414167">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet Ocolor" title="OMIM"><a ref="ncbi_uid=414167" target="_blank" href="/omim/120920">O</a></span><span class="chiclet Gcolor" title="GeneReviews"><a target="_blank" href="/books/NBK1367/" ref="ncbi_uid=414167">G</a></span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&from_uid=414167" ref="ncbi_uid=414167">V</a></span></span><span class="TLline"><a href="/medgen/414167" ref="tree=GTR&ncbi_uid=414167&link_uid=414167" title="View MedGen record for 'Atypical hemolytic-uremic syndrome with MCP/CD46 anomaly'">Atypical hemolytic-uremic syndrome with MCP/CD46 anomaly</a></span></li><li class="TLclosed"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C2752036[DISCUI]&test_type=Clinical" ref="ncbi_uid=414541">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet Ocolor" title="OMIM"><a ref="ncbi_uid=414541" target="_blank" href="/omim/188040">O</a></span><span class="chiclet Gcolor" title="GeneReviews"><a target="_blank" href="/books/NBK1367/" ref="ncbi_uid=414541">G</a></span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&from_uid=414541" ref="ncbi_uid=414541">V</a></span></span><span class="TLline"><a href="/medgen/414541" ref="tree=GTR&ncbi_uid=414541&link_uid=414541" title="View MedGen record for 'Atypical hemolytic-uremic syndrome with thrombomodulin anomaly'">Atypical hemolytic-uremic syndrome with thrombomodulin anomaly</a></span></li><li class="TLclosed"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=CN036211[DISCUI]&test_type=Clinical" ref="ncbi_uid=430731">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet unavailable" title="OMIM">O</span><span class="chiclet Gcolor" title="GeneReviews"><a target="_blank" href="/books/NBK1367/" ref="ncbi_uid=430731">G</a></span><span class="chiclet unavailable" title="ClinVar">V</span></span><span class="TLline"><a href="/medgen/430731" ref="tree=GTR&ncbi_uid=430731&link_uid=430731" title="View MedGen record for 'Hemolytic uremic syndrome, atypical, childhood'">Hemolytic uremic syndrome, atypical, childhood</a></span></li><li class="TLclosed"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C1969906[DISCUI]&test_type=Clinical" ref="ncbi_uid=370773">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet Ocolor" title="OMIM"><a ref="ncbi_uid=370773" target="_blank" href="/omim/134371">O</a></span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&from_uid=370773" ref="ncbi_uid=370773">V</a></span></span><span class="TLline"><a href="/medgen/370773" ref="tree=GTR&ncbi_uid=370773&link_uid=370773" title="View MedGen record for 'Hemolytic uremic syndrome, atypical, susceptibility to'">Hemolytic uremic syndrome, atypical, susceptibility to</a></span></li><li class="TLclosed"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C2749604[DISCUI]&test_type=Clinical" ref="ncbi_uid=412743">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet Ocolor" title="OMIM"><a ref="ncbi_uid=412743" target="_blank" href="/omim/134370">O</a></span><span class="chiclet Gcolor" title="GeneReviews"><a target="_blank" href="/books/NBK1367/" ref="ncbi_uid=412743">G</a></span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&from_uid=412743" ref="ncbi_uid=412743">V</a></span></span><span class="TLline"><a href="/medgen/412743" ref="tree=GTR&ncbi_uid=412743&link_uid=412743" title="View MedGen record for 'Hemolytic uremic syndrome, atypical, susceptibility to, 1'">Hemolytic uremic syndrome, atypical, susceptibility to, 1</a></span></li></ul></li><li class="TLclosed"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=CN072396[DISCUI]&test_type=Clinical&redirect=true" ref="ncbi_uid=449003">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet unavailable" title="OMIM">O</span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet unavailable" title="ClinVar">V</span></span><span class="TLline"><a href="/medgen/449003" ref="tree=GTR&ncbi_uid=449003&link_uid=449003" title="View MedGen record for 'D-plus hemolytic uremic syndrome (D+HUS)'">D-plus hemolytic uremic syndrome (D+HUS)</a></span></li><li class="TLclosed"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C1268937[DISCUI]&test_type=Clinical&redirect=true" ref="ncbi_uid=692757">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet unavailable" title="OMIM">O</span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet unavailable" title="ClinVar">V</span></span><span class="TLline"><a href="/medgen/692757" ref="tree=GTR&ncbi_uid=692757&link_uid=692757" title="View MedGen record for 'Diarrhea-negative hemolytic uremic syndrome'">Diarrhea-negative hemolytic uremic syndrome</a></span></li></ul></li></ul></div></div></div></div></div><div id="tabMGEN"><div class="ds_tree"><ul><li><span class="TLline"><a href="/medgen/1254" ref="tree=MeSH" title="MedGen record for Fetal anomaly">Fetal anomaly</a></span><ul><li><span class="TLline"><a href="/medgen/474891" ref="tree=MeSH" title="MedGen record for Congenital Systemic Disorder">Congenital Systemic Disorder</a></span><ul><li><span class="TLline"><a href="/medgen/52948" ref="tree=MeSH" title="MedGen record for Abnormality of the genitourinary system">Abnormality of the genitourinary system</a></span><ul><li><span class="TLline"><a href="/medgen/867444" ref="tree=MeSH" title="MedGen record for Abnormality of the urinary system">Abnormality of the urinary system</a></span><ul><li><span class="TLline"><a href="/medgen/869020" ref="tree=MeSH" title="MedGen record for Abnormality of the urinary system physiology">Abnormality of the urinary system physiology</a></span><ul><li><span class="TLline"><a href="/medgen/508816" ref="tree=MeSH" title="MedGen record for Abnormal renal physiology">Abnormal renal physiology</a></span><ul><li><span class="matched_ds">Hemolytic-uremic syndrome</span><ul><li><span class="TLline"><a href="/medgen/444141" ref="tree=MeSH" title="MedGen record for Atypical hemolytic-uremic syndrome">Atypical hemolytic-uremic syndrome</a></span><ul><li><span class="TLline"><a href="/medgen/1842625" ref="tree=MeSH" title="MedGen record for Atypical hemolytic uremic syndrome with complement gene abnormality">Atypical hemolytic uremic syndrome with complement gene abnormality</a></span></li><li><span class="TLline"><a href="/medgen/1788163" ref="tree=MeSH" title="MedGen record for Atypical Hemolytic Uremic Syndrome-4">Atypical Hemolytic Uremic Syndrome-4</a></span></li><li><span class="TLline"><a href="/medgen/1825998" ref="tree=MeSH" title="MedGen record for Atypical hemolytic-uremic syndrome with anti-factor H antibodies">Atypical hemolytic-uremic syndrome with anti-factor H antibodies</a></span></li><li><span class="TLline"><a href="/medgen/416691" ref="tree=MeSH" title="MedGen record for Atypical hemolytic-uremic syndrome with B factor anomaly">Atypical hemolytic-uremic syndrome with B factor anomaly</a></span></li><li><span class="TLline"><a href="/medgen/442875" ref="tree=MeSH" title="MedGen record for Atypical hemolytic-uremic syndrome with C3 anomaly">Atypical hemolytic-uremic syndrome with C3 anomaly</a></span></li><li><span class="TLline"><a href="/medgen/414542" ref="tree=MeSH" title="MedGen record for Atypical hemolytic-uremic syndrome with I factor anomaly">Atypical hemolytic-uremic syndrome with I factor anomaly</a></span></li><li><span class="TLline"><a href="/medgen/414167" ref="tree=MeSH" title="MedGen record for Atypical hemolytic-uremic syndrome with MCP/CD46 anomaly">Atypical hemolytic-uremic syndrome with MCP/CD46 anomaly</a></span></li><li><span class="TLline"><a href="/medgen/414541" ref="tree=MeSH" title="MedGen record for Atypical hemolytic-uremic syndrome with thrombomodulin anomaly">Atypical hemolytic-uremic syndrome with thrombomodulin anomaly</a></span></li><li><span class="TLline"><a href="/medgen/885565" ref="tree=MeSH" title="MedGen record for Familial Atypical Hemolytic-Uremic Syndrome">Familial Atypical Hemolytic-Uremic Syndrome</a></span></li><li><span class="TLline"><a href="/medgen/430731" ref="tree=MeSH" title="MedGen record for Hemolytic uremic syndrome, atypical, childhood">Hemolytic uremic syndrome, atypical, childhood</a></span></li><li><span class="TLline"><a href="/medgen/370773" ref="tree=MeSH" title="MedGen record for Hemolytic uremic syndrome, atypical, susceptibility to">Hemolytic uremic syndrome, atypical, susceptibility to</a></span></li><li><span class="TLline"><a href="/medgen/412743" ref="tree=MeSH" title="MedGen record for Hemolytic uremic syndrome, atypical, susceptibility to, 1">Hemolytic uremic syndrome, atypical, susceptibility to, 1</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/1826167" ref="tree=MeSH" title="MedGen record for Atypical hemolytic-uremic syndrome with DGKE deficiency">Atypical hemolytic-uremic syndrome with DGKE deficiency</a></span></li><li><span class="TLline"><a href="/medgen/341256" ref="tree=MeSH" title="MedGen record for Cobalamin C disease">Cobalamin C disease</a></span></li><li><span class="TLline"><a href="/medgen/449003" ref="tree=MeSH" title="MedGen record for D-plus hemolytic uremic syndrome (D+HUS)">D-plus hemolytic uremic syndrome (D+HUS)</a></span></li><li><span class="TLline"><a href="/medgen/692756" ref="tree=MeSH" title="MedGen record for Diarrhea-associated hemolytic uremic syndrome">Diarrhea-associated hemolytic uremic syndrome</a></span></li><li><span class="TLline"><a href="/medgen/692757" ref="tree=MeSH" title="MedGen record for Diarrhea-negative hemolytic uremic syndrome">Diarrhea-negative hemolytic uremic syndrome</a></span></li><li><span class="TLline"><a href="/medgen/1826072" ref="tree=MeSH" title="MedGen record for Infection-related hemolytic uremic syndrome">Infection-related hemolytic uremic syndrome</a></span><ul><li><span class="TLline"><a href="/medgen/383843" ref="tree=MeSH" title="MedGen record for Shiga toxin-associated hemolytic uremic syndrome">Shiga toxin-associated hemolytic uremic syndrome</a></span></li><li><span class="TLline"><a href="/medgen/1842720" ref="tree=MeSH" title="MedGen record for Streptococcus pneumoniae-associated hemolytic uremic syndrome">Streptococcus pneumoniae-associated hemolytic uremic syndrome</a></span></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></div></div></div></div>
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Conditions_with_this_feature">Conditions with this feature</h1><a sid="112" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="divPopper rprt" id="rdis_224783"><div><strong>Upshaw-Schulman syndrome</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>224783</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1268935</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
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<div class="spaceAbove">Hereditary thrombotic thrombocytopenic purpura (TTP), also known as Upshaw-Schulman syndrome (USS), is a rare autosomal recessive thrombotic microangiopathy (TMA). Clinically, acute phases of TTP are defined by microangiopathic mechanical hemolytic anemia, severe thrombocytopenia, and visceral ischemia. Hereditary TTP makes up 5% of TTP cases and is caused mostly by biallelic mutation in the ADAMTS13 gene, or in very rare cases, by monoallelic ADAMTS13 mutation associated with a cluster of single-nucleotide polymorphisms (SNPs); most cases of all TTP (95%) are acquired via an autoimmune mechanism (see 188030). Hereditary TTP is more frequent among child-onset TTP compared with adult-onset TTP, and its clinical presentation is significantly different as a function of its age of onset. Child-onset TTP usually starts in the neonatal period with hematological features and severe jaundice. In contrast, almost all cases of adult-onset hereditary TTP are unmasked during the first pregnancy of a woman whose disease was silent during childhood (summary by Joly et al., 2018).</div>
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<div class="spaceAbove nowrap">See: <a href="/medgen/224783">Condition Record</a></div></div>
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<div class="divPopper rprt" id="rdis_341256"><div><strong>Cobalamin C disease</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>341256</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1848561</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
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<div class="spaceAbove">Disorders of intracellular cobalamin metabolism have a variable phenotype and age of onset that are influenced by the severity and location within the pathway of the defect. The prototype and best understood phenotype is cblC; it is also the most common of these disorders. The age of initial presentation of cblC spans a wide range: In utero with fetal presentation of nonimmune hydrops, cardiomyopathy, and intrauterine growth restriction. Newborns, who can have microcephaly, poor feeding, and encephalopathy. Infants, who can have poor feeding and slow growth, neurologic abnormality, and, rarely, hemolytic uremic syndrome (HUS). Toddlers, who can have poor growth, progressive microcephaly, cytopenias (including megaloblastic anemia), global developmental delay, encephalopathy, and neurologic signs such as hypotonia and seizures. Adolescents and adults, who can have neuropsychiatric symptoms, progressive cognitive decline, thromboembolic complications, and/or subacute combined degeneration of the spinal cord.</div>
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<div class="spaceAbove nowrap">See: <a href="/medgen/341256">Condition Record</a></div></div>
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<div class="divPopper rprt" id="rdis_412743"><div><strong>Hemolytic uremic syndrome, atypical, susceptibility to, 1</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>412743</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C2749604</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Finding</dd></dl></div></div></div>
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<div class="spaceAbove">Hemolytic-uremic syndrome (HUS) is characterized by hemolytic anemia, thrombocytopenia, and renal failure caused by platelet thrombi in the microcirculation of the kidney and other organs. The onset of atypical HUS (aHUS) ranges from the neonatal period to adulthood. Genetic aHUS accounts for an estimated 60% of all aHUS. Individuals with genetic aHUS frequently experience relapse even after complete recovery following the presenting episode; 60% of genetic aHUS progresses to end-stage renal disease (ESRD).</div>
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<div class="spaceAbove nowrap">See: <a href="/medgen/412743">Condition Record</a></div></div>
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<div class="divPopper rprt" id="rdis_414541"><div><strong>Atypical hemolytic-uremic syndrome with thrombomodulin anomaly</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>414541</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C2752036</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Finding</dd></dl></div></div></div>
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<div class="spaceAbove">Hemolytic-uremic syndrome (HUS) is characterized by hemolytic anemia, thrombocytopenia, and renal failure caused by platelet thrombi in the microcirculation of the kidney and other organs. The onset of atypical HUS (aHUS) ranges from the neonatal period to adulthood. Genetic aHUS accounts for an estimated 60% of all aHUS. Individuals with genetic aHUS frequently experience relapse even after complete recovery following the presenting episode; 60% of genetic aHUS progresses to end-stage renal disease (ESRD).</div>
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<div class="spaceAbove nowrap">See: <a href="/medgen/414541">Condition Record</a></div></div>
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<div class="divPopper rprt" id="rdis_442875"><div><strong>Atypical hemolytic-uremic syndrome with C3 anomaly</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>442875</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C2752037</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Finding</dd></dl></div></div></div>
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<div class="spaceAbove">Hemolytic-uremic syndrome (HUS) is characterized by hemolytic anemia, thrombocytopenia, and renal failure caused by platelet thrombi in the microcirculation of the kidney and other organs. The onset of atypical HUS (aHUS) ranges from the neonatal period to adulthood. Genetic aHUS accounts for an estimated 60% of all aHUS. Individuals with genetic aHUS frequently experience relapse even after complete recovery following the presenting episode; 60% of genetic aHUS progresses to end-stage renal disease (ESRD).</div>
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<div class="spaceAbove nowrap">See: <a href="/medgen/442875">Condition Record</a></div></div>
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<div class="divPopper rprt" id="rdis_416691"><div><strong>Atypical hemolytic-uremic syndrome with B factor anomaly</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>416691</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C2752038</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Finding</dd></dl></div></div></div>
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<div class="spaceAbove">Hemolytic-uremic syndrome (HUS) is characterized by hemolytic anemia, thrombocytopenia, and renal failure caused by platelet thrombi in the microcirculation of the kidney and other organs. The onset of atypical HUS (aHUS) ranges from the neonatal period to adulthood. Genetic aHUS accounts for an estimated 60% of all aHUS. Individuals with genetic aHUS frequently experience relapse even after complete recovery following the presenting episode; 60% of genetic aHUS progresses to end-stage renal disease (ESRD).</div>
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<div class="spaceAbove nowrap">See: <a href="/medgen/416691">Condition Record</a></div></div>
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<div class="divPopper rprt" id="rdis_414542"><div><strong>Atypical hemolytic-uremic syndrome with I factor anomaly</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>414542</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C2752039</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Finding</dd></dl></div></div></div>
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<div class="spaceAbove">Hemolytic-uremic syndrome (HUS) is characterized by hemolytic anemia, thrombocytopenia, and renal failure caused by platelet thrombi in the microcirculation of the kidney and other organs. The onset of atypical HUS (aHUS) ranges from the neonatal period to adulthood. Genetic aHUS accounts for an estimated 60% of all aHUS. Individuals with genetic aHUS frequently experience relapse even after complete recovery following the presenting episode; 60% of genetic aHUS progresses to end-stage renal disease (ESRD).</div>
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<div class="spaceAbove nowrap">See: <a href="/medgen/414542">Condition Record</a></div></div>
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<div class="divPopper rprt" id="rdis_414167"><div><strong>Atypical hemolytic-uremic syndrome with MCP/CD46 anomaly</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>414167</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C2752040</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Finding</dd></dl></div></div></div>
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<div class="spaceAbove">Hemolytic-uremic syndrome (HUS) is characterized by hemolytic anemia, thrombocytopenia, and renal failure caused by platelet thrombi in the microcirculation of the kidney and other organs. The onset of atypical HUS (aHUS) ranges from the neonatal period to adulthood. Genetic aHUS accounts for an estimated 60% of all aHUS. Individuals with genetic aHUS frequently experience relapse even after complete recovery following the presenting episode; 60% of genetic aHUS progresses to end-stage renal disease (ESRD).</div>
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<div class="spaceAbove nowrap">See: <a href="/medgen/414167">Condition Record</a></div></div>
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<div class="divPopper rprt" id="rdis_443957"><div><strong>COG1 congenital disorder of glycosylation</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>443957</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C2931011</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
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<div class="spaceAbove">An extremely rare form of carbohydrate deficient glycoprotein syndrome with, in the few cases reported to date, variable signs including microcephaly, growth retardation, psychomotor retardation and facial dysmorphism.</div>
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<div class="spaceAbove nowrap">See: <a href="/medgen/443957">Condition Record</a></div></div>
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<div class="divPopper rprt" id="rdis_766485"><div><strong>TMEM165-congenital disorder of glycosylation</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>766485</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C3553571</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
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<div class="spaceAbove">CDG2K is an autosomal recessive disorder with a variable phenotype. Affected individuals show psychomotor retardation and growth retardation, and most have short stature. Other features include dysmorphism, hypotonia, eye abnormalities, acquired microcephaly, hepatomegaly, and skeletal dysplasia. Serum transferrin analysis shows a CDG type II pattern (summary by Foulquier et al., 2012). For a general discussion of CDGs, see CDG1A (212065) and CDG2A (212066).</div>
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<div class="spaceAbove nowrap">See: <a href="/medgen/766485">Condition Record</a></div></div>
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<div class="divPopper rprt" id="rdis_767244"><div><strong>Immunoglobulin-mediated membranoproliferative glomerulonephritis</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>767244</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C3554330</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
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<div class="spaceAbove">C3 glomerulopathy (C3G) is a complex ultra-rare complement-mediated renal disease caused by uncontrolled activation of the complement alternative pathway (AP) in the fluid phase (as opposed to cell surface) that is rarely inherited in a simple mendelian fashion. C3G affects individuals of all ages, with a median age at diagnosis of 23 years. Individuals with C3G typically present with hematuria, proteinuria, hematuria and proteinuria, acute nephritic syndrome or nephrotic syndrome, and low levels of the complement component C3. Spontaneous remission of C3G is uncommon, and about half of affected individuals develop end-stage renal disease (ESRD) within ten years of diagnosis, occasionally developing the late comorbidity of impaired visual acuity.</div>
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<div class="spaceAbove nowrap">See: <a href="/medgen/767244">Condition Record</a></div></div>
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<div class="divPopper rprt" id="rdis_1794283"><div><strong>Immunodeficiency 91 and hyperinflammation</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1794283</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C5562073</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
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<div class="spaceAbove">Immunodeficiency-91 and hyperinflammation (IMD91) is an autosomal recessive complex immunologic disorder characterized by both immunodeficiency and recurrent infections, often to viruses or mycobacteria, as well as by hyperinflammation with systemic involvement. Affected individuals present in infancy with variable features, including fever, infection, thrombocytopenia, renal or hepatic dysfunction, recurrent infections, or seizures. Most patients eventually develop hepatic or renal failure, compromised neurologic function, lymphadenopathy or hepatosplenomegaly, and multiorgan failure resulting in death. More variable features may include intermittent monocytosis, features of hemophagocytic lymphohistiocytosis (HLH), and serologic evidence of hyperinflammation. The disorder is thought to result from dysregulation of the interferon response to viral stimulation in the innate immune system (summary by Le Voyer et al., 2021; Vavassori et al., 2021).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1794283">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_1840221"><div><strong>Hemolytic uremic syndrome, atypical, 8, with rhizomelic short stature</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1840221</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C5829585</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Atypical hemolytic uremic syndrome-8 with rhizomelic short stature (AHUS8) is an X-linked disorder with variable manifestations. The age at onset of renal symptoms is variable, ranging from infancy to the early twenties. Features of atypical hemolytic uremic syndrome (aHUS) include acute renal dysfunction with proteinuria, thrombotic microangiopathy, anemia, thrombocytopenia, increased serum lactate dehydrogenase (LDH), and schistocytes on peripheral blood smear. Affected individuals also have short stature with short limbs. More variable features include immunodeficiency with recurrent infections, developmental delay, and dysmorphic features. Treatment with C5 inhibitors results in improvement of renal function. Female carriers may show an attenuated phenotype (Hadar et al., 2023; Erger et al., 2023). For a discussion of genetic heterogeneity of aHUS, see AHUS1 (235400).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1840221">Condition Record</a></div></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_416691" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Atypical hemolytic-uremic syndrome with B factor anomaly</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_442875" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Atypical hemolytic-uremic syndrome with C3 anomaly</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_414542" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Atypical hemolytic-uremic syndrome with I factor anomaly</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_414167" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Atypical hemolytic-uremic syndrome with MCP/CD46 anomaly</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_414541" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Atypical hemolytic-uremic syndrome with thrombomodulin anomaly</a></div><div class="jig-moreless" data-jigconfig="class: 'moveDown', moreText: 'See full list (13)', lessText: 'Show less', nodeBefore: 0"><span id="clinMore">
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_341256" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Cobalamin C disease</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_443957" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">COG1 congenital disorder of glycosylation</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1840221" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Hemolytic uremic syndrome, atypical, 8, with rhizomelic short stature</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_412743" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Hemolytic uremic syndrome, atypical, susceptibility to, 1</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1794283" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Immunodeficiency 91 and hyperinflammation</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_767244" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Immunoglobulin-mediated membranoproliferative glomerulonephritis</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_766485" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">TMEM165-congenital disorder of glycosylation</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_224783" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Upshaw-Schulman syndrome</a></div></span></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_105">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Professional_guidelines">Professional guidelines</h1><a sid="105" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">PubMed<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpPM"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/37610060">Clinical Evaluation and Management of Thrombotic Microangiopathy.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Leisring J,
|
||
Brodsky SV,
|
||
Parikh SV</span><br />
|
||
<span class="medgenPMjournal">Arthritis Rheumatol</span>
|
||
2024 Feb;76(2):153-165.
|
||
Epub 2023 Nov 30
|
||
doi: 10.1002/art.42681.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37610060" target="_blank">37610060</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/36668830">Diagnosis and Treatment for Shiga Toxin-Producing Escherichia coli Associated Hemolytic Uremic Syndrome.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Liu Y,
|
||
Thaker H,
|
||
Wang C,
|
||
Xu Z,
|
||
Dong M</span><br />
|
||
<span class="medgenPMjournal">Toxins (Basel)</span>
|
||
2022 Dec 23;15(1)
|
||
doi: 10.3390/toxins15010010.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36668830" target="_blank">36668830</a><a href="/pmc/articles/PMC9862836" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/30294946">Atypical Hemolytic-Uremic Syndrome: An Update on Pathophysiology, Diagnosis, and Treatment.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Raina R,
|
||
Krishnappa V,
|
||
Blaha T,
|
||
Kann T,
|
||
Hein W,
|
||
Burke L,
|
||
Bagga A</span><br />
|
||
<span class="medgenPMjournal">Ther Apher Dial</span>
|
||
2019 Feb;23(1):4-21.
|
||
Epub 2018 Oct 29
|
||
doi: 10.1111/1744-9987.12763.
|
||
<span class="bold">PMID: </span><a href="/pubmed/30294946" target="_blank">30294946</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(%22hemolytic-uremic%20syndrome%22%5Btiab%3A~0%5D)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">See all (244)</a></div></div>
|
||
</div>
|
||
<div class="display-none help-popup" id="guidelinesHelpPM">These guidelines are articles in PubMed that match specific search criteria developed by MedGen to capture the most relevant practice guidelines. This list may not be comprehensive and may include broader topics as well. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div><div class="display-none help-popup" id="guidelinesHelpCurated">These guidelines are manually curated by the MedGen team
|
||
to supplement articles available in PubMed. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div>
|
||
<div class="portlet mgSection" id="ID_103">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_clinical_studies">Recent clinical studies</h1><a sid="103" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">Etiology</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/36683290">Complement-driven hemolytic uremic syndrome.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Leon J,
|
||
LeStang MB,
|
||
Sberro-Soussan R,
|
||
Servais A,
|
||
Anglicheau D,
|
||
Frémeaux-Bacchi V,
|
||
Zuber J</span><br />
|
||
<span class="medgenPMjournal">Am J Hematol</span>
|
||
2023 May;98 Suppl 4:S44-S56.
|
||
doi: 10.1002/ajh.26854.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36683290" target="_blank">36683290</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/36322940">How I diagnose and treat atypical hemolytic uremic syndrome.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Fakhouri F,
|
||
Schwotzer N,
|
||
Frémeaux-Bacchi V</span><br />
|
||
<span class="medgenPMjournal">Blood</span>
|
||
2023 Mar 2;141(9):984-995.
|
||
doi: 10.1182/blood.2022017860.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36322940" target="_blank">36322940</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/36272423">Haemolytic uraemic syndrome.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Michael M,
|
||
Bagga A,
|
||
Sartain SE,
|
||
Smith RJH</span><br />
|
||
<span class="medgenPMjournal">Lancet</span>
|
||
2022 Nov 12;400(10364):1722-1740.
|
||
Epub 2022 Oct 19
|
||
doi: 10.1016/S0140-6736(22)01202-8.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36272423" target="_blank">36272423</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/29042465">Thrombotic Microangiopathy and the Kidney.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Brocklebank V,
|
||
Wood KM,
|
||
Kavanagh D</span><br />
|
||
<span class="medgenPMjournal">Clin J Am Soc Nephrol</span>
|
||
2018 Feb 7;13(2):300-317.
|
||
Epub 2017 Oct 17
|
||
doi: 10.2215/CJN.00620117.
|
||
<span class="bold">PMID: </span><a href="/pubmed/29042465" target="_blank">29042465</a><a href="/pmc/articles/PMC5967417" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/28242109">Haemolytic uraemic syndrome.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Fakhouri F,
|
||
Zuber J,
|
||
Frémeaux-Bacchi V,
|
||
Loirat C</span><br />
|
||
<span class="medgenPMjournal">Lancet</span>
|
||
2017 Aug 12;390(10095):681-696.
|
||
Epub 2017 Feb 25
|
||
doi: 10.1016/S0140-6736(17)30062-4.
|
||
<span class="bold">PMID: </span><a href="/pubmed/28242109" target="_blank">28242109</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Hemolytic-uremic%20syndrome%22%20AND%20Etiology%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (2033)</a></div><h3 class="subhead">Diagnosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/36322940">How I diagnose and treat atypical hemolytic uremic syndrome.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Fakhouri F,
|
||
Schwotzer N,
|
||
Frémeaux-Bacchi V</span><br />
|
||
<span class="medgenPMjournal">Blood</span>
|
||
2023 Mar 2;141(9):984-995.
|
||
doi: 10.1182/blood.2022017860.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36322940" target="_blank">36322940</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/36880929">Hemolytic-Uremic Syndrome in Children.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Boyer O,
|
||
Niaudet P</span><br />
|
||
<span class="medgenPMjournal">Pediatr Clin North Am</span>
|
||
2022 Dec;69(6):1181-1197.
|
||
Epub 2022 Oct 29
|
||
doi: 10.1016/j.pcl.2022.07.006.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36880929" target="_blank">36880929</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/32238553">Hemolytic Uremic Syndrome.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Viteri B,
|
||
Saland JM</span><br />
|
||
<span class="medgenPMjournal">Pediatr Rev</span>
|
||
2020 Apr;41(4):213-215.
|
||
doi: 10.1542/pir.2018-0346.
|
||
<span class="bold">PMID: </span><a href="/pubmed/32238553" target="_blank">32238553</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/30294946">Atypical Hemolytic-Uremic Syndrome: An Update on Pathophysiology, Diagnosis, and Treatment.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Raina R,
|
||
Krishnappa V,
|
||
Blaha T,
|
||
Kann T,
|
||
Hein W,
|
||
Burke L,
|
||
Bagga A</span><br />
|
||
<span class="medgenPMjournal">Ther Apher Dial</span>
|
||
2019 Feb;23(1):4-21.
|
||
Epub 2018 Oct 29
|
||
doi: 10.1111/1744-9987.12763.
|
||
<span class="bold">PMID: </span><a href="/pubmed/30294946" target="_blank">30294946</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/5016348">Hemolytic-uremic syndrome.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Lieberman E</span><br />
|
||
<span class="medgenPMjournal">J Pediatr</span>
|
||
1972 Jan;80(1):1-16.
|
||
doi: 10.1016/s0022-3476(72)80445-1.
|
||
<span class="bold">PMID: </span><a href="/pubmed/5016348" target="_blank">5016348</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Hemolytic-uremic%20syndrome%22%20AND%20Diagnosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (2472)</a></div><h3 class="subhead">Therapy</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/29998801">HELLP Syndrome: Pathophysiology and Current Therapies.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Wallace K,
|
||
Harris S,
|
||
Addison A,
|
||
Bean C</span><br />
|
||
<span class="medgenPMjournal">Curr Pharm Biotechnol</span>
|
||
2018;19(10):816-826.
|
||
doi: 10.2174/1389201019666180712115215.
|
||
<span class="bold">PMID: </span><a href="/pubmed/29998801" target="_blank">29998801</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/28242109">Haemolytic uraemic syndrome.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Fakhouri F,
|
||
Zuber J,
|
||
Frémeaux-Bacchi V,
|
||
Loirat C</span><br />
|
||
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<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Hemolytic-uremic%20syndrome%22%20AND%20Clinical%20prediction%20guides%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (1099)</a></div></div>
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</div>
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<div class="portlet mgSection" id="ID_104">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_systematic_reviews">Recent systematic reviews</h1><a sid="104" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="portlet_content ln">
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<div class="nl"><a target="_blank" href="/pubmed/35118546">Systematic review of atypical hemolytic uremic syndrome biomarkers.</a></div>
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Sethi SK,
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Dragon-Durey MA,
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Khooblall A,
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Sharma D,
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Khandelwal P,
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Shapiro R,
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Boyer O,
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Yap HK,
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Bagga A,
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Licht C</span><br />
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<span class="medgenPMjournal">Pediatr Nephrol</span>
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2022 Jul;37(7):1479-1493.
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Epub 2022 Feb 3
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doi: 10.1007/s00467-022-05451-2.
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<span class="bold">PMID: </span><a href="/pubmed/35118546" target="_blank">35118546</a></div>
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<div class="nl"><a target="_blank" href="/pubmed/33687995">Therapeutic Targeting of the Complement System: From Rare Diseases to Pandemics.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Garred P,
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Tenner AJ,
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Mollnes TE</span><br />
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<span class="medgenPMjournal">Pharmacol Rev</span>
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<span class="bold">PMID: </span><a href="/pubmed/33687995" target="_blank">33687995</a><a href="/pmc/articles/PMC7956994" target="_blank" class="PubMedFree">Free PMC Article</a></div>
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|
||
<div class="nl"><a target="_blank" href="/pubmed/31809447">Pregnancy-Associated Atypical Hemolytic Uremic Syndrome: A Systematic Review.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Gupta M,
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Govindappagari S,
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Burwick RM</span><br />
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<span class="bold">PMID: </span><a href="/pubmed/31809447" target="_blank">31809447</a><a href="/pmc/articles/PMC6922068" target="_blank" class="PubMedFree">Free PMC Article</a></div>
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||
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||
<div class="nl"><a target="_blank" href="/pubmed/25414441">Drug-induced thrombotic microangiopathy: a systematic review of published reports.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Al-Nouri ZL,
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Reese JA,
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Terrell DR,
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Vesely SK,
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George JN</span><br />
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<span class="medgenPMjournal">Blood</span>
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2015 Jan 22;125(4):616-8.
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Epub 2014 Nov 20
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doi: 10.1182/blood-2014-11-611335.
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<span class="bold">PMID: </span><a href="/pubmed/25414441" target="_blank">25414441</a><a href="/pmc/articles/PMC4304106" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/15198745">Is fresh frozen plasma clinically effective? A systematic review of randomized controlled trials.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Stanworth SJ,
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Brunskill SJ,
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Hyde CJ,
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<span class="bold">PMID: </span><a href="/pubmed/15198745" target="_blank">15198745</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Hemolytic-uremic%20syndrome%22%20AND%20systematic%5Bsb%5D%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (46)</a></div></div>
|
||
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|
||
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|
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<h2 class="offscreen_noflow">Supplemental Content</h2>
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<div class="portlet_content ln"><ul><li><a href="/gtr/tests?term=C0019061%5bDISCUI%5d&filter=method%3A2%5F8" target="_blank">Deletion/duplication analysis (9)</a></li>
|
||
<li><a href="/gtr/tests?term=C0019061%5bDISCUI%5d&filter=method%3A2%5F7" target="_blank">Sequence analysis of the entire coding region (10)</a></li>
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<li class="portletSeeAll portletSeeAllPad"><total><a href="/gtr/tests?term=C0019061%5bDISCUI%5d" target="_blank">See all (10)</a></total></li>
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<div class="portlet_content ln"><ul><li><a href="http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Expert=544458" target="_blank">Orphanet</a></li><li><a href="https://clinicaltrials.gov/search?cond=Hemolytic-uremic%20syndrome" target="_blank">ClinicalTrials.gov</a></li></ul></div>
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<div class="portlet_content ln"><ul class="a_poppers"><li><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(%22hemolytic-uremic%20syndrome%22%5Btiab%3A~0%5D)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">PubMed</a><div class="help-popup">See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div></li><li><a target="_blank" href="/books/?term=((%22clinical%20guidelines%22%5BResource%20Type%5D)%20OR%20%22practice%20guideline%22%5BPublication%20Type%5D)%20AND%20(%22Hemolytic-uremic%20syndrome%22)">Bookshelf</a><div class="help-popup">See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div></li></ul></div>
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