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<meta name="keywords" content="C0016059, fibroplasia, fibroses, fibrosis, fibrous repair, fibrous replacement, fibrous thickening, pathologic function, autosomal dominant, autosomal recessive, birth defects, chromosomal disease, chromosome, clinical features, clinical findings, clinical genetics, clinical recommendations, clinvar, congenital chromosomal disease, consumer genetic resources, cytogenetic location, disease characteristics, disease definitions, disease descriptions, disease ontology, disease synonyms, disease vocabulary, dysmorphology, entrez, familial disease, gene, gene-disease relationship, genereviews, genetic disease, genetic disorder, genetic terminology, genetic testing registry, genetics home reference, genomic disease, gtr, hereditary disease, heritable disease, hpo, human phenotype ontology, inherited disease, management guidelines, maternal inheritance, medgen, medical genetics, medical subject headings, mesh, mitochondrial inheritance, mode of inheritance, national center for biotechnology information, national institutes of health, national library of medicine, ncbi, nih, nlm, omim, ordo, orphanet, paternal inheritance, phenome, position statements, professional practice guidelines, rare disease, reference sequence, refseq, snomed ct, syndrome, undiagnosed diseases, x-linked recessive" /><meta name="description" content="The formation of fibrous tissue." /><meta name="robots" content="index,nofollow,noarchive" />
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<!--
UID=5179
ConceptID=C0016059
-->
<!--imgCountBooks = 0--><h1 class="medgenTitle"><div class="MedGenTitleText">Fibrosis</div></h1><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>5179</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information."><span class="highlight" style="background-color:">C0016059</span></a></dd><dt><span class="dotprefix"></span></dt><dd>Pathologic Function</dd></dl></div></div><table class="medgenTable"><tbody><tr><td>Synonym:</td>
<td>Fibroses</td></tr>
<tr><td><span class="bold">SNOMED CT: </span></td>
<td>Fibrosis (112674009); Fibrous repair (112674009); Fibrous thickening (112674009); Fibroplasia (112674009); Fibrous replacement (112674009); Fibrosis (263756000)</td></tr>
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<div class="portlet mgSection" id="ID_100">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Definition">Definition</h1><a sid="100" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln">The formation of fibrous tissue. [from <a title="NCI Thesaurus" href="http://ncit.nci.nih.gov" class="defSource" target="_blank">NCI</a>]</div>
</div>
<div class="portlet mgSection" id="ID_118">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Term_Hierarchy">Term Hierarchy</h1><a sid="118" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln HierarchyGTR"><div class="jig-ncbitabs"><ul><li><a href="#tabGTR">GTR</a></li><li><a href="#tabMGEN">MeSH</a></li></ul><div id="tabGTR"><div class="search_result"><div class="rprts"><div class="chiclet_legend"><span class="chiclet_list" style="position:static;"><span title="Clinical test" class="chiclet Ccolor round">C</span><span>Clinical test,  </span><span title="Research test" class="chiclet Rcolor round">R</span><span>Research test,  </span><span title="OMIM" class="chiclet Ocolor ">O</span><span>OMIM,  </span><span title="GeneReview" class="chiclet Gcolor">G</span><span><em>GeneReviews</em>,  </span><span title="ClinVar" class="chiclet Vcolor">V</span><span>ClinVar  </span></span></div><div id="hierarchy" class="margin_t1"><div class="ds_tree"><ul><li class="matched_ds"><span class="TLline">Fibrosis</span></li></ul></div></div></div></div></div><div id="tabMGEN"><div class="ds_tree"><ul><li><span class="TLline"><a href="/medgen/415490" ref="tree=MeSH" title="MedGen record for Histopathology Result">Histopathology Result</a></span><ul><li><span class="TLline"><a href="/medgen/147104" ref="tree=MeSH" title="MedGen record for Morphologic finding">Morphologic finding</a></span><ul><li><span class="matched_ds">Fibrosis</span><ul><li><span class="TLline"><a href="/medgen/811048" ref="tree=MeSH" title="MedGen record for Bone Marrow Fibrosis">Bone Marrow Fibrosis</a></span><ul><li><span class="TLline"><a href="/medgen/232375" ref="tree=MeSH" title="MedGen record for Collagen Fibrosis of the Bone Marrow">Collagen Fibrosis of the Bone Marrow</a></span></li><li><span class="TLline"><a href="/medgen/269156" ref="tree=MeSH" title="MedGen record for Marked Bone Marrow Fibrosis">Marked Bone Marrow Fibrosis</a></span></li><li><span class="TLline"><a href="/medgen/233921" ref="tree=MeSH" title="MedGen record for Reticulin Fibrosis of the Bone Marrow">Reticulin Fibrosis of the Bone Marrow</a></span><ul><li><span class="TLline"><a href="/medgen/269238" ref="tree=MeSH" title="MedGen record for Minimal Reticulin Fibrosis of the Bone Marrow">Minimal Reticulin Fibrosis of the Bone Marrow</a></span></li></ul></li></ul></li><li><span class="TLline"><a href="/medgen/137724" ref="tree=MeSH" title="MedGen record for Bridging fibrosis">Bridging fibrosis</a></span></li><li><span class="TLline"><a href="/medgen/7368" ref="tree=MeSH" title="MedGen record for Cirrhosis of liver">Cirrhosis of liver</a></span><ul><li><span class="TLline"><a href="/medgen/6125" ref="tree=MeSH" title="MedGen record for Alcoholic liver cirrhosis">Alcoholic liver cirrhosis</a></span><ul><li><span class="TLline"><a href="/medgen/1740454" ref="tree=MeSH" title="MedGen record for Alcoholic Cirrhosis of Liver with Ascites">Alcoholic Cirrhosis of Liver with Ascites</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/44182" ref="tree=MeSH" title="MedGen record for Biliary cirrhosis">Biliary cirrhosis</a></span><ul><li><span class="TLline"><a href="/medgen/3035" ref="tree=MeSH" title="MedGen record for Primary biliary cholangitis">Primary biliary cholangitis</a></span></li><li><span class="TLline"><a href="/medgen/68653" ref="tree=MeSH" title="MedGen record for Secondary biliary cirrhosis">Secondary biliary cirrhosis</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/1676576" ref="tree=MeSH" title="MedGen record for Cirrhosis of the Liver Secondary to Hepatitis B">Cirrhosis of the Liver Secondary to Hepatitis B</a></span></li><li><span class="TLline"><a href="/medgen/82760" ref="tree=MeSH" title="MedGen record for Cirrhosis, cryptogenic">Cirrhosis, cryptogenic</a></span></li><li><span class="TLline"><a href="/medgen/1674707" ref="tree=MeSH" title="MedGen record for Hepatitis C induced liver cirrhosis">Hepatitis C induced liver cirrhosis</a></span></li><li><span class="TLline"><a href="/medgen/384466" ref="tree=MeSH" title="MedGen record for Macronodular cirrhosis">Macronodular cirrhosis</a></span></li><li><span class="TLline"><a href="/medgen/75640" ref="tree=MeSH" title="MedGen record for Micronodular cirrhosis">Micronodular cirrhosis</a></span></li><li><span class="TLline"><a href="/medgen/853247" ref="tree=MeSH" title="MedGen record for Mixed cirrhosis">Mixed cirrhosis</a></span></li><li><span class="TLline"><a href="/medgen/351440" ref="tree=MeSH" title="MedGen record for Portal cirrhosis">Portal cirrhosis</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/823782" ref="tree=MeSH" title="MedGen record for Concentric Fibrosis of Intrahepatic Duct">Concentric Fibrosis of Intrahepatic Duct</a></span></li><li><span class="TLline"><a href="/medgen/287965" ref="tree=MeSH" title="MedGen record for Deep Connective Tissue Fibrosis">Deep Connective Tissue Fibrosis</a></span></li><li><span class="TLline"><a href="/medgen/99264" ref="tree=MeSH" title="MedGen record for Focal fibrosis">Focal fibrosis</a></span></li><li><span class="TLline"><a href="/medgen/384469" ref="tree=MeSH" title="MedGen record for Healing scar">Healing scar</a></span><ul><li><span class="TLline"><a href="/medgen/7891" ref="tree=MeSH" title="MedGen record for Adhesion">Adhesion</a></span></li><li><span class="TLline"><a href="/medgen/234106" ref="tree=MeSH" title="MedGen record for Central Scar">Central Scar</a></span></li><li><span class="TLline"><a href="/medgen/83899" ref="tree=MeSH" title="MedGen record for Corneal scarring">Corneal scarring</a></span></li><li><span class="TLline"><a href="/medgen/7197" ref="tree=MeSH" title="MedGen record for Keloids">Keloids</a></span><ul><li><span class="TLline"><a href="/medgen/1720" ref="tree=MeSH" title="MedGen record for Acne keloid">Acne keloid</a></span></li></ul></li></ul></li><li><span class="TLline"><a href="/medgen/116093" ref="tree=MeSH" title="MedGen record for Hepatic fibrosis">Hepatic fibrosis</a></span><ul><li><span class="TLline"><a href="/medgen/40449" ref="tree=MeSH" title="MedGen record for Congenital hepatic fibrosis">Congenital hepatic fibrosis</a></span></li><li><span class="TLline"><a href="/medgen/868315" ref="tree=MeSH" title="MedGen record for Hepatic bridging fibrosis">Hepatic bridging fibrosis</a></span></li><li><span class="TLline"><a href="/medgen/337906" ref="tree=MeSH" title="MedGen record for Periportal fibrosis">Periportal fibrosis</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/20554" ref="tree=MeSH" title="MedGen record for IgG4-related retroperitoneal fibrosis">IgG4-related retroperitoneal fibrosis</a></span><ul><li><span class="TLline"><a href="/medgen/887340" ref="tree=MeSH" title="MedGen record for Idiopathic retroperitoneal fibrosis">Idiopathic retroperitoneal fibrosis</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/233692" ref="tree=MeSH" title="MedGen record for Meningeal Fibrosis">Meningeal Fibrosis</a></span></li><li><span class="TLline"><a href="/medgen/56239" ref="tree=MeSH" title="MedGen record for Myocardial fibrosis">Myocardial fibrosis</a></span><ul><li><span class="TLline"><a href="/medgen/107513" ref="tree=MeSH" title="MedGen record for Endocardial fibrosis">Endocardial fibrosis</a></span></li><li><span class="TLline"><a href="/medgen/1620902" ref="tree=MeSH" title="MedGen record for Interstitial cardiac fibrosis">Interstitial cardiac fibrosis</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/301436" ref="tree=MeSH" title="MedGen record for Nephrogenic fibrosing dermopathy">Nephrogenic fibrosing dermopathy</a></span></li><li><span class="TLline"><a href="/medgen/141740" ref="tree=MeSH" title="MedGen record for Peritoneal fibrosis">Peritoneal fibrosis</a></span></li><li><span class="TLline"><a href="/medgen/87194" ref="tree=MeSH" title="MedGen record for Perivascular fibrosis">Perivascular fibrosis</a></span><ul><li><span class="TLline"><a href="/medgen/1612197" ref="tree=MeSH" title="MedGen record for Perivascular cardiac fibrosis">Perivascular cardiac fibrosis</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/857486" ref="tree=MeSH" title="MedGen record for Placental Villous Fibrosis">Placental Villous Fibrosis</a></span></li><li><span class="TLline"><a href="/medgen/11028" ref="tree=MeSH" title="MedGen record for Pulmonary fibrosis">Pulmonary fibrosis</a></span><ul><li><span class="TLline"><a href="/medgen/1778266" ref="tree=MeSH" title="MedGen record for Bilateral apical pulmonary fibrosis">Bilateral apical pulmonary fibrosis</a></span></li><li><span class="TLline"><a href="/medgen/573414" ref="tree=MeSH" title="MedGen record for Bilateral basilar pulmonary fibrosis">Bilateral basilar pulmonary fibrosis</a></span></li><li><span class="TLline"><a href="/medgen/167847" ref="tree=MeSH" title="MedGen record for Diffuse pulmonary fibrosis">Diffuse pulmonary fibrosis</a></span></li><li><span class="TLline"><a href="/medgen/321462" ref="tree=MeSH" title="MedGen record for Idiopathic Pulmonary Fibrosis">Idiopathic Pulmonary Fibrosis</a></span><ul><li><span class="TLline"><a href="/medgen/39340" ref="tree=MeSH" title="MedGen record for Acute interstitial pneumonia">Acute interstitial pneumonia</a></span></li><li><span class="TLline"><a href="/medgen/389939" ref="tree=MeSH" title="MedGen record for Idiopathic interstitial pneumonia">Idiopathic interstitial pneumonia</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/137936" ref="tree=MeSH" title="MedGen record for Localized pulmonary fibrosis">Localized pulmonary fibrosis</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/305636" ref="tree=MeSH" title="MedGen record for Superficial Soft Tissue Fibrosis">Superficial Soft Tissue Fibrosis</a></span></li></ul></li></ul></li></ul></li></ul></div></div></div></div>
</div>
<div class="portlet mgSection" id="ID_105">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Professional_guidelines">Professional guidelines</h1><a sid="105" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln"><h3 class="subhead">PubMed<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpPM"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3>
<div class="nl"><a target="_blank" href="/pubmed/36517177">Progressive pulmonary fibrosis: an expert group consensus statement.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Rajan SK,
Cottin V,
Dhar R,
Danoff S,
Flaherty KR,
Brown KK,
Mohan A,
Renzoni E,
Mohan M,
Udwadia Z,
Shenoy P,
Currow D,
Devraj A,
Jankharia B,
Kulshrestha R,
Jones S,
Ravaglia C,
Quadrelli S,
Iyer R,
Dhooria S,
Kolb M,
Wells AU</span><br />
<span class="medgenPMjournal">Eur Respir J</span>
2023 Mar;61(3)
Epub 2023 Mar 30
doi: 10.1183/13993003.03187-2021.
<span class="bold">PMID: </span><a href="/pubmed/36517177" target="_blank">36517177</a><a href="/pmc/articles/PMC10060665" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/32636299">Treatment of nontuberculous mycobacterial pulmonary disease: an official ATS/ERS/ESCMID/IDSA clinical practice guideline.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Daley CL,
Iaccarino JM,
Lange C,
Cambau E,
Wallace RJ Jr,
Andrejak C,
Böttger EC,
Brozek J,
Griffith DE,
Guglielmetti L,
Huitt GA,
Knight SL,
Leitman P,
Marras TK,
Olivier KN,
Santin M,
Stout JE,
Tortoli E,
van Ingen J,
Wagner D,
Winthrop KL</span><br />
<span class="medgenPMjournal">Eur Respir J</span>
2020 Jul;56(1)
Epub 2020 Jul 7
doi: 10.1183/13993003.00535-2020.
<span class="bold">PMID: </span><a href="/pubmed/32636299" target="_blank">32636299</a><a href="/pmc/articles/PMC8375621" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/29154106">Diagnostic criteria for idiopathic pulmonary fibrosis: a Fleischner Society White Paper.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Lynch DA,
Sverzellati N,
Travis WD,
Brown KK,
Colby TV,
Galvin JR,
Goldin JG,
Hansell DM,
Inoue Y,
Johkoh T,
Nicholson AG,
Knight SL,
Raoof S,
Richeldi L,
Ryerson CJ,
Ryu JH,
Wells AU</span><br />
<span class="medgenPMjournal">Lancet Respir Med</span>
2018 Feb;6(2):138-153.
Epub 2017 Nov 15
doi: 10.1016/S2213-2600(17)30433-2.
<span class="bold">PMID: </span><a href="/pubmed/29154106" target="_blank">29154106</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(%22fibrosis%22%5Btiab%3A~0%5D)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">See all (9186)</a></div></div>
</div>
<div class="display-none help-popup" id="guidelinesHelpPM">These guidelines are articles in PubMed that match specific search criteria developed by MedGen to capture the most relevant practice guidelines. This list may not be comprehensive and may include broader topics as well. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div><div class="display-none help-popup" id="guidelinesHelpCurated">These guidelines are manually curated by the MedGen team
to supplement articles available in PubMed. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div>
<div class="portlet mgSection" id="ID_103">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_clinical_studies">Recent clinical studies</h1><a sid="103" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln"><h3 class="subhead">Etiology</h3>
<div class="nl"><a target="_blank" href="/pubmed/32234292">Mitochondria dysfunction and metabolic reprogramming as drivers of idiopathic pulmonary fibrosis.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Bueno M,
Calyeca J,
Rojas M,
Mora AL</span><br />
<span class="medgenPMjournal">Redox Biol</span>
2020 Jun;33:101509.
Epub 2020 Mar 19
doi: 10.1016/j.redox.2020.101509.
<span class="bold">PMID: </span><a href="/pubmed/32234292" target="_blank">32234292</a><a href="/pmc/articles/PMC7251240" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/31713590">Atrial fibrillation and cardiac fibrosis.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Sohns C,
Marrouche NF</span><br />
<span class="medgenPMjournal">Eur Heart J</span>
2020 Mar 7;41(10):1123-1131.
doi: 10.1093/eurheartj/ehz786.
<span class="bold">PMID: </span><a href="/pubmed/31713590" target="_blank">31713590</a></div>
<div class="nl"><a target="_blank" href="/pubmed/31046975">Liver Fibrosis Determination.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Lai M,
Afdhal NH</span><br />
<span class="medgenPMjournal">Gastroenterol Clin North Am</span>
2019 Jun;48(2):281-289.
Epub 2019 Apr 1
doi: 10.1016/j.gtc.2019.02.002.
<span class="bold">PMID: </span><a href="/pubmed/31046975" target="_blank">31046975</a></div>
<div class="nl"><a target="_blank" href="/pubmed/28345383">Pulmonary fibrosis, part I: epidemiology, pathogenesis, and diagnosis.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Meyer KC</span><br />
<span class="medgenPMjournal">Expert Rev Respir Med</span>
2017 May;11(5):343-359.
Epub 2017 Apr 10
doi: 10.1080/17476348.2017.1312346.
<span class="bold">PMID: </span><a href="/pubmed/28345383" target="_blank">28345383</a></div>
<div class="nl"><a target="_blank" href="/pubmed/27299520">Acute Exacerbation of Idiopathic Pulmonary Fibrosis. An International Working Group Report.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Collard HR,
Ryerson CJ,
Corte TJ,
Jenkins G,
Kondoh Y,
Lederer DJ,
Lee JS,
Maher TM,
Wells AU,
Antoniou KM,
Behr J,
Brown KK,
Cottin V,
Flaherty KR,
Fukuoka J,
Hansell DM,
Johkoh T,
Kaminski N,
Kim DS,
Kolb M,
Lynch DA,
Myers JL,
Raghu G,
Richeldi L,
Taniguchi H,
Martinez FJ</span><br />
<span class="medgenPMjournal">Am J Respir Crit Care Med</span>
2016 Aug 1;194(3):265-75.
doi: 10.1164/rccm.201604-0801CI.
<span class="bold">PMID: </span><a href="/pubmed/27299520" target="_blank">27299520</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Fibrosis%22%20AND%20Etiology%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (63324)</a></div><h3 class="subhead">Diagnosis</h3>
<div class="nl"><a target="_blank" href="/pubmed/36537095">Progressive pulmonary fibrosis (PPF).</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Duman D</span><br />
<span class="medgenPMjournal">Tuberk Toraks</span>
2022 Dec;70(4):375-381.
doi: 10.5578/tt.20229609.
<span class="bold">PMID: </span><a href="/pubmed/36537095" target="_blank">36537095</a></div>
<div class="nl"><a target="_blank" href="/pubmed/28365056">Idiopathic pulmonary fibrosis.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Richeldi L,
Collard HR,
Jones MG</span><br />
<span class="medgenPMjournal">Lancet</span>
2017 May 13;389(10082):1941-1952.
Epub 2017 Mar 30
doi: 10.1016/S0140-6736(17)30866-8.
<span class="bold">PMID: </span><a href="/pubmed/28365056" target="_blank">28365056</a></div>
<div class="nl"><a target="_blank" href="/pubmed/28345383">Pulmonary fibrosis, part I: epidemiology, pathogenesis, and diagnosis.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Meyer KC</span><br />
<span class="medgenPMjournal">Expert Rev Respir Med</span>
2017 May;11(5):343-359.
Epub 2017 Apr 10
doi: 10.1080/17476348.2017.1312346.
<span class="bold">PMID: </span><a href="/pubmed/28345383" target="_blank">28345383</a></div>
<div class="nl"><a target="_blank" href="/pubmed/16427494">Retroperitoneal fibrosis.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Vaglio A,
Salvarani C,
Buzio C</span><br />
<span class="medgenPMjournal">Lancet</span>
2006 Jan 21;367(9506):241-51.
doi: 10.1016/S0140-6736(06)68035-5.
<span class="bold">PMID: </span><a href="/pubmed/16427494" target="_blank">16427494</a></div>
<div class="nl"><a target="_blank" href="/pubmed/2405786">Cystic fibrosis.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">David TJ</span><br />
<span class="medgenPMjournal">Arch Dis Child</span>
1990 Jan;65(1):152-7.
doi: 10.1136/adc.65.1.152.
<span class="bold">PMID: </span><a href="/pubmed/2405786" target="_blank">2405786</a><a href="/pmc/articles/PMC1792392" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Fibrosis%22%20AND%20Diagnosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (55435)</a></div><h3 class="subhead">Therapy</h3>
<div class="nl"><a target="_blank" href="/pubmed/34299189">Current Options and Future Directions for NAFLD and NASH Treatment.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Zhang C,
Yang M</span><br />
<span class="medgenPMjournal">Int J Mol Sci</span>
2021 Jul 15;22(14)
doi: 10.3390/ijms22147571.
<span class="bold">PMID: </span><a href="/pubmed/34299189" target="_blank">34299189</a><a href="/pmc/articles/PMC8306701" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/31996266">Progression of fibrosing interstitial lung disease.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Wong AW,
Ryerson CJ,
Guler SA</span><br />
<span class="medgenPMjournal">Respir Res</span>
2020 Jan 29;21(1):32.
doi: 10.1186/s12931-020-1296-3.
<span class="bold">PMID: </span><a href="/pubmed/31996266" target="_blank">31996266</a><a href="/pmc/articles/PMC6988233" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/25681399">Pathobiology of liver fibrosis: a translational success story.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Lee YA,
Wallace MC,
Friedman SL</span><br />
<span class="medgenPMjournal">Gut</span>
2015 May;64(5):830-41.
Epub 2015 Feb 13
doi: 10.1136/gutjnl-2014-306842.
<span class="bold">PMID: </span><a href="/pubmed/25681399" target="_blank">25681399</a><a href="/pmc/articles/PMC4477794" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/15516680">Azithromycin for cystic fibrosis.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Southern KW,
Barker PM</span><br />
<span class="medgenPMjournal">Eur Respir J</span>
2004 Nov;24(5):834-8.
doi: 10.1183/09031936.04.00084304.
<span class="bold">PMID: </span><a href="/pubmed/15516680" target="_blank">15516680</a></div>
<div class="nl"><a target="_blank" href="/pubmed/15057662">Pirfenidone.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Lasky J</span><br />
<span class="medgenPMjournal">IDrugs</span>
2004 Feb;7(2):166-72.
<span class="bold">PMID: </span><a href="/pubmed/15057662" target="_blank">15057662</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Fibrosis%22%20AND%20Therapy%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (48309)</a></div><h3 class="subhead">Prognosis</h3>
<div class="nl"><a target="_blank" href="/pubmed/30482684">Sudden Death Risk-Stratification in 2018-2019: The Old and the New.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Zaman S,
Goldberger JJ,
Kovoor P</span><br />
<span class="medgenPMjournal">Heart Lung Circ</span>
2019 Jan;28(1):57-64.
Epub 2018 Sep 25
doi: 10.1016/j.hlc.2018.08.027.
<span class="bold">PMID: </span><a href="/pubmed/30482684" target="_blank">30482684</a></div>
<div class="nl"><a target="_blank" href="/pubmed/27469176">Background and Epidemiology.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Sanders DB,
Fink AK</span><br />
<span class="medgenPMjournal">Pediatr Clin North Am</span>
2016 Aug;63(4):567-84.
doi: 10.1016/j.pcl.2016.04.001.
<span class="bold">PMID: </span><a href="/pubmed/27469176" target="_blank">27469176</a><a href="/pmc/articles/PMC4967225" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/25976683">Global incidence and mortality of idiopathic pulmonary fibrosis: a systematic review.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Hutchinson J,
Fogarty A,
Hubbard R,
McKeever T</span><br />
<span class="medgenPMjournal">Eur Respir J</span>
2015 Sep;46(3):795-806.
Epub 2015 May 14
doi: 10.1183/09031936.00185114.
<span class="bold">PMID: </span><a href="/pubmed/25976683" target="_blank">25976683</a></div>
<div class="nl"><a target="_blank" href="/pubmed/20012067">Forgotten cardiovascular diseases in Africa.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Sliwa K,
Mocumbi AO</span><br />
<span class="medgenPMjournal">Clin Res Cardiol</span>
2010 Feb;99(2):65-74.
Epub 2009 Dec 11
doi: 10.1007/s00392-009-0094-1.
<span class="bold">PMID: </span><a href="/pubmed/20012067" target="_blank">20012067</a></div>
<div class="nl"><a target="_blank" href="/pubmed/10228739">Pyogenic lung infections.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Mwandumba HC,
Beeching NJ</span><br />
<span class="medgenPMjournal">Curr Opin Pulm Med</span>
1999 May;5(3):151-6.
doi: 10.1097/00063198-199905000-00005.
<span class="bold">PMID: </span><a href="/pubmed/10228739" target="_blank">10228739</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Fibrosis%22%20AND%20Prognosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (40846)</a></div><h3 class="subhead">Clinical prediction guides</h3>
<div class="nl"><a target="_blank" href="/pubmed/32670469">Cardiac Magnetic Resonance in Nonischemic Cardiomyopathies.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Yang EY,
Shah DJ</span><br />
<span class="medgenPMjournal">Methodist Debakey Cardiovasc J</span>
2020 Apr-Jun;16(2):97-105.
doi: 10.14797/mdcj-16-2-97.
<span class="bold">PMID: </span><a href="/pubmed/32670469" target="_blank">32670469</a><a href="/pmc/articles/PMC7350809" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/27981309">Noninvasive Assessment of Liver Diseases using 2D Shear Wave Elastography.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Lupșor-Platon M,
Badea R,
Gersak M,
Maniu A,
Rusu I,
Suciu A,
Vicas C,
Stefănescu H,
Urs R,
Al Hajjar N</span><br />
<span class="medgenPMjournal">J Gastrointestin Liver Dis</span>
2016 Dec;25(4):525-532.
doi: 10.15403/jgld.2014.1121.254.lup.
<span class="bold">PMID: </span><a href="/pubmed/27981309" target="_blank">27981309</a></div>
<div class="nl"><a target="_blank" href="/pubmed/27063270">Histology of Nonalcoholic Fatty Liver Disease and Nonalcoholic Steatohepatitis in Adults and Children.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Kleiner DE,
Makhlouf HR</span><br />
<span class="medgenPMjournal">Clin Liver Dis</span>
2016 May;20(2):293-312.
Epub 2015 Dec 28
doi: 10.1016/j.cld.2015.10.011.
<span class="bold">PMID: </span><a href="/pubmed/27063270" target="_blank">27063270</a><a href="/pmc/articles/PMC4829204" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/25400438">Histopathology of nonalcoholic fatty liver disease/nonalcoholic steatohepatitis.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Takahashi Y,
Fukusato T</span><br />
<span class="medgenPMjournal">World J Gastroenterol</span>
2014 Nov 14;20(42):15539-48.
doi: 10.3748/wjg.v20.i42.15539.
<span class="bold">PMID: </span><a href="/pubmed/25400438" target="_blank">25400438</a><a href="/pmc/articles/PMC4229519" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/15915461">Design and validation of a histological scoring system for nonalcoholic fatty liver disease.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Kleiner DE,
Brunt EM,
Van Natta M,
Behling C,
Contos MJ,
Cummings OW,
Ferrell LD,
Liu YC,
Torbenson MS,
Unalp-Arida A,
Yeh M,
McCullough AJ,
Sanyal AJ;
Nonalcoholic Steatohepatitis Clinical Research Network</span><br />
<span class="medgenPMjournal">Hepatology</span>
2005 Jun;41(6):1313-21.
doi: 10.1002/hep.20701.
<span class="bold">PMID: </span><a href="/pubmed/15915461" target="_blank">15915461</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Fibrosis%22%20AND%20Clinical%20prediction%20guides%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (50820)</a></div></div>
</div>
<div class="portlet mgSection" id="ID_104">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_systematic_reviews">Recent systematic reviews</h1><a sid="104" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln">
<div class="nl"><a target="_blank" href="/pubmed/35816813">Improving nutrition in cystic fibrosis: A systematic literature review.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Mielus M,
Sands D,
Woynarowski M</span><br />
<span class="medgenPMjournal">Nutrition</span>
2022 Oct;102:111725.
Epub 2022 May 6
doi: 10.1016/j.nut.2022.111725.
<span class="bold">PMID: </span><a href="/pubmed/35816813" target="_blank">35816813</a></div>
<div class="nl"><a target="_blank" href="/pubmed/35499854">Nintedanib in Progressive Pulmonary Fibrosis: A Systematic Review and Meta-Analysis.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Ghazipura M,
Mammen MJ,
Herman DD,
Hon SM,
Bissell BD,
Macrea M,
Kheir F,
Khor YH,
Knight SL,
Raghu G,
Wilson KC,
Hossain T</span><br />
<span class="medgenPMjournal">Ann Am Thorac Soc</span>
2022 Jun;19(6):1040-1049.
doi: 10.1513/AnnalsATS.202103-343OC.
<span class="bold">PMID: </span><a href="/pubmed/35499854" target="_blank">35499854</a></div>
<div class="nl"><a target="_blank" href="/pubmed/34895203">Efficacy of antifibrotic drugs, nintedanib and pirfenidone, in treatment of progressive pulmonary fibrosis in both idiopathic pulmonary fibrosis (IPF) and non-IPF: a systematic review and meta-analysis.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Finnerty JP,
Ponnuswamy A,
Dutta P,
Abdelaziz A,
Kamil H</span><br />
<span class="medgenPMjournal">BMC Pulm Med</span>
2021 Dec 11;21(1):411.
doi: 10.1186/s12890-021-01783-1.
<span class="bold">PMID: </span><a href="/pubmed/34895203" target="_blank">34895203</a><a href="/pmc/articles/PMC8666028" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/28130788">Increased risk of mortality by fibrosis stage in nonalcoholic fatty liver disease: Systematic review and meta-analysis.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Dulai PS,
Singh S,
Patel J,
Soni M,
Prokop LJ,
Younossi Z,
Sebastiani G,
Ekstedt M,
Hagstrom H,
Nasr P,
Stal P,
Wong VW,
Kechagias S,
Hultcrantz R,
Loomba R</span><br />
<span class="medgenPMjournal">Hepatology</span>
2017 May;65(5):1557-1565.
Epub 2017 Mar 31
doi: 10.1002/hep.29085.
<span class="bold">PMID: </span><a href="/pubmed/28130788" target="_blank">28130788</a><a href="/pmc/articles/PMC5397356" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/24768810">Fibrosis progression in nonalcoholic fatty liver vs nonalcoholic steatohepatitis: a systematic review and meta-analysis of paired-biopsy studies.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Singh S,
Allen AM,
Wang Z,
Prokop LJ,
Murad MH,
Loomba R</span><br />
<span class="medgenPMjournal">Clin Gastroenterol Hepatol</span>
2015 Apr;13(4):643-54.e1-9; quiz e39-40.
Epub 2014 Apr 24
doi: 10.1016/j.cgh.2014.04.014.
<span class="bold">PMID: </span><a href="/pubmed/24768810" target="_blank">24768810</a><a href="/pmc/articles/PMC4208976" target="_blank" class="PubMedFree">Free PMC Article</a></div>
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