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<meta name="keywords" content="C0004943, adamantiades behcet disease, adamantiades-behcet disease, adamantiades-behcet diseases, bd, bechet syndrome, behcet disease, behcet syndrome, behcet triple symptom complex, behcet's disease, behcet's syndrome, behet's syndrome, behçet disease, behçet diseases, behçet syndrome, behçet's disease, behçet's syndrome, behçet-adamantiades syndrome, behçets disease, disease or syndrome, morbus behçet's syndrome, old silk route disease, silk road disease, symptom complex, triple, triple symptom complex, triple symptom complices, triple-symptom complex, autosomal dominant, autosomal recessive, birth defects, chromosomal disease, chromosome, clinical features, clinical findings, clinical genetics, clinical recommendations, clinvar, congenital chromosomal disease, consumer genetic resources, cytogenetic location, disease characteristics, disease definitions, disease descriptions, disease ontology, disease synonyms, disease vocabulary, dysmorphology, entrez, familial disease, gene, gene-disease relationship, genereviews, genetic disease, genetic disorder, genetic terminology, genetic testing registry, genetics home reference, genomic disease, gtr, hereditary disease, heritable disease, hpo, human phenotype ontology, inherited disease, management guidelines, maternal inheritance, medgen, medical genetics, medical subject headings, mesh, mitochondrial inheritance, mode of inheritance, national center for biotechnology information, national institutes of health, national library of medicine, ncbi, nih, nlm, omim, ordo, orphanet, paternal inheritance, phenome, position statements, professional practice guidelines, rare disease, reference sequence, refseq, snomed ct, syndrome, undiagnosed diseases, x-linked recessive" /><meta name="description" content="Behçet disease is an inflammatory condition that affects many parts of the body. The health problems associated with Behçet disease result from widespread inflammation of blood vessels (vasculitis). This inflammation most commonly affects small blood vessels in the mouth, genitals, skin, and eyes.\n\nPainful mouth sores called aphthous ulcers are usually the first sign of Behçet disease. These sores can occur on the lips, tongue, inside the cheeks, the roof of the mouth, the throat, and the tonsils. The ulcers look like common canker sores, and they typically heal within one to two weeks. About 75 percent of all people with Behçet disease develop similar ulcers on the genitals. These ulcers occur most frequently on the scrotum in men and on the labia in women.\n\nBehçet disease can also cause painful bumps and sores on the skin. Most affected individuals develop pus-filled bumps that resemble acne. These bumps can occur anywhere on the body. Some affected people also have red, tender nodules called erythema nodosum. These nodules usually develop on the legs but can also occur on the arms, face, and neck.\n\nAn inflammation of the eye called uveitis is found in more than half of people with Behçet disease. Eye problems are more common in younger people with the disease and affect men more often than women. Uveitis can result in blurry vision and an extreme sensitivity to light (photophobia). Rarely, inflammation can also cause eye pain and redness. If untreated, the eye problems associated with Behçet disease can lead to blindness.\n\nJoint involvement is also common in Behçet disease. Often this affects one joint at a time, with each affected joint becoming swollen and painful and then getting better.\n\nLess commonly, Behçet disease can affect the brain and spinal cord (central nervous system), gastrointestinal tract, large blood vessels, heart, lungs, and kidneys. Central nervous system abnormalities can lead to headaches, confusion, personality changes, memory loss, impaired speech, and problems with balance and movement. Involvement of the gastrointestinal tract can lead to a hole in the wall of the intestine (intestinal perforation), which can cause serious infection and may be life-threatening.\n\nThe signs and symptoms of Behçet disease usually begin in a person's twenties or thirties, although they can appear at any age. Some affected people have relatively mild symptoms that are limited to sores in the mouth and on the genitals. Others have more severe symptoms affecting various parts of the body, including the eyes and the vital organs. The features of Behçet disease typically come and go over a period of months or years. In most affected individuals, the health problems associated with this disorder improve with age." /><meta name="robots" content="index,nofollow,noarchive" />
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<!--
UID=2568
ConceptID=C0004943
-->
<!--imgCountBooks = 0--><h1 class="medgenTitle"><div class="MedGenTitleText">Behcet disease<span class="h1sub">(BD)</span></div></h1><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>2568</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information."><span class="highlight" style="background-color:">C0004943</span></a></dd><dt><span class="dotprefix"></span></dt><dd>Disease or Syndrome</dd></dl></div></div><table class="medgenTable"><tbody><tr><td>Synonyms:</td>
<td>BD; Behcet Syndrome; Behcet's disease; Behcet's syndrome</td></tr>
<tr><td><span class="bold">SNOMED CT: </span></td>
<td>Adamantiades-Behcet disease (310701003); Behcet syndrome (310701003); Behcet's syndrome (310701003); Behcet's disease (310701003)</td></tr>
<tr><td>Modes of inheritance:</td>
<td>
<div class="divPopper rprt" id="moi_109109"><div><strong>Non-Mendelian inheritance</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>109109</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C0600599</a></dd><dt><span class="dotprefix"></span></dt><dd>Genetic Function</dd></dl></div></div></div>
<div class="spaceAbove">Source: Orphanet</div>
<div class="spaceAbove">A mode of inheritance that depends on genetic determinants in more than one gene.</div></div>
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#moi_109109" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Non-Mendelian inheritance</a><span> (Orphanet)</span></div></td></tr>
<tr><td colspan="2" class="small"> </td></tr><tr><td>Monarch Initiative:</td>
<td><a href="https://monarchinitiative.org/disease/MONDO:0007191" target="_blank">MONDO:0007191</a></td></tr>
<tr><td>OMIM<span class="superscript">®</span>:</td>
<td><a href="https://omim.org/entry/109650" target="_blank">109650</a></td></tr>
<tr><td>Orphanet:</td>
<td><a target="_blank" title="Orphanet: The portal for rare diseases and orphan drugs" href="http://www.orpha.net/consor/cgi-bin/OC_Exp.php?lng=EN&amp;Expert=117">ORPHA117</a></td></tr></tbody></table></div><div class="rprt-body jig-ncbiinpagenav" data-jigconfig="smoothScroll: false, gotoTopLink: true, gotoTopLinkText: '', gotoTopLinkAttrs: {'title': 'Go to the top of the page'},allHeadingLevels: ['h1'], topOfPageTOC: true, tocId: 'my-toc'"><div id="rprt-tabs-1" class="rprt-tab"><div id="tb-termsProp-1"><div class="leftCol mgCol"><div>
<div class="portlet mgSection" id="ID_100">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Definition">Definition</h1><a sid="100" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln">Behçet disease is an inflammatory condition that affects many parts of the body. The health problems associated with Behçet disease result from widespread inflammation of blood vessels (vasculitis). This inflammation most commonly affects small blood vessels in the mouth, genitals, skin, and eyes.<br /><br />Painful mouth sores called aphthous ulcers are usually the first sign of Behçet disease. These sores can occur on the lips, tongue, inside the cheeks, the roof of the mouth, the throat, and the tonsils. The ulcers look like common canker sores, and they typically heal within one to two weeks. About 75 percent of all people with Behçet disease develop similar ulcers on the genitals. These ulcers occur most frequently on the scrotum in men and on the labia in women.<br /><br />Behçet disease can also cause painful bumps and sores on the skin. Most affected individuals develop pus-filled bumps that resemble acne. These bumps can occur anywhere on the body. Some affected people also have red, tender nodules called erythema nodosum. These nodules usually develop on the legs but can also occur on the arms, face, and neck.<br /><br />An inflammation of the eye called uveitis is found in more than half of people with Behçet disease. Eye problems are more common in younger people with the disease and affect men more often than women. Uveitis can result in blurry vision and an extreme sensitivity to light (photophobia). Rarely, inflammation can also cause eye pain and redness. If untreated, the eye problems associated with Behçet disease can lead to blindness.<br /><br />Joint involvement is also common in Behçet disease. Often this affects one joint at a time, with each affected joint becoming swollen and painful and then getting better.<br /><br />Less commonly, Behçet disease can affect the brain and spinal cord (central nervous system), gastrointestinal tract, large blood vessels, heart, lungs, and kidneys. Central nervous system abnormalities can lead to headaches, confusion, personality changes, memory loss, impaired speech, and problems with balance and movement. Involvement of the gastrointestinal tract can lead to a hole in the wall of the intestine (intestinal perforation), which can cause serious infection and may be life-threatening.<br /><br />The signs and symptoms of Behçet disease usually begin in a person's twenties or thirties, although they can appear at any age. Some affected people have relatively mild symptoms that are limited to sores in the mouth and on the genitals. Others have more severe symptoms affecting various parts of the body, including the eyes and the vital organs. The features of Behçet disease typically come and go over a period of months or years. In most affected individuals, the health problems associated with this disorder improve with age. [from <a title="MedlinePlus Genetics" href="https://medlineplus.gov/genetics/" class="defSource" target="_blank">MedlinePlus Genetics</a>]</div>
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Clinical_features">Clinical features</h1><a sid="102" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln clinfeat"><strong>From HPO</strong><br />
<div class="divPopper rprt" id="clin_57716"><div><strong>Genital ulcers</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>57716</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C0151281</a></dd><dt><span class="dotprefix"></span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
<div class="spaceAbove nowrap">See: <a href="/medgen/57716">Feature record</a> | <a href="/medgen?term=%22Genital%20ulcers%22%5BClinical%20Features%5D%20OR%2057716%5Buid%5D">Search on this feature</a></div></div>
<div class="divPopper rprt" id="clin_1636806"><div><strong>Decreased level of D-mannose in urine</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1636806</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C4703626</a></dd><dt><span class="dotprefix"></span></dt><dd>Finding</dd></dl></div></div></div>
<div class="spaceAbove">A decrease in the level of D-mannose in the urine.</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/1636806">Feature record</a> | <a href="/medgen?term=%22Decreased%20level%20of%20D-mannose%20in%20urine%22%5BClinical%20Features%5D%20OR%201636806%5Buid%5D">Search on this feature</a></div></div>
<div class="divPopper rprt" id="clin_20474"><div><strong>Raynaud phenomenon</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>20474</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C0034735</a></dd><dt><span class="dotprefix"></span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
<div class="spaceAbove">An episodic vasoconstriction resulting in discoloration of the skin and pain in the affected areas, often involving fingers or toes. Classically associated with triphasic color changes (white, blue, red) but may be biphasic. Often occurs in response to cold temperatures or emotional stress. May be primary or secondary to an underlying autoimmune disease.</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/20474">Feature record</a> | <a href="/medgen?term=%22Raynaud%20phenomenon%22%5BClinical%20Features%5D%20OR%2020474%5Buid%5D">Search on this feature</a></div></div>
<div class="divPopper rprt" id="clin_397841"><div><strong>Irritability</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>397841</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C2700617</a></dd><dt><span class="dotprefix"></span></dt><dd>Mental Process</dd></dl></div></div></div>
<div class="spaceAbove">A proneness to anger, i.e., a tendency to become easily bothered or annoyed.</div>
<div class="spaceAbove nowrap">See: <a href="/medgen?term=%22Irritability%22%5BClinical%20Features%5D%20OR%20397841%5Buid%5D">Search on this feature</a></div></div>
<div class="divPopper rprt" id="clin_266934"><div><strong>Superficial thrombophlebitis</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>266934</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C1510431</a></dd><dt><span class="dotprefix"></span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
<div class="spaceAbove">Inflammation of a superficial vein associated with venous thrombosis (blood clot formation within the vein).</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/266934">Feature record</a> | <a href="/medgen?term=%22Superficial%20thrombophlebitis%22%5BClinical%20Features%5D%20OR%20266934%5Buid%5D">Search on this feature</a></div></div>
<div class="divPopper rprt" id="clin_2043"><div><strong>Arthritis</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>2043</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C0003864</a></dd><dt><span class="dotprefix"></span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
<div class="spaceAbove">Inflammation of a joint.</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/2043">Feature record</a> | <a href="/medgen?term=%22Arthritis%22%5BClinical%20Features%5D%20OR%202043%5Buid%5D">Search on this feature</a></div></div>
<div class="divPopper rprt" id="clin_4986"><div><strong>Epididymitis</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>4986</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C0014534</a></dd><dt><span class="dotprefix"></span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
<div class="spaceAbove">The presence of inflammation of the epididymis.</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/4986">Feature record</a> | <a href="/medgen?term=%22Epididymitis%22%5BClinical%20Features%5D%20OR%204986%5Buid%5D">Search on this feature</a></div></div>
<div class="divPopper rprt" id="clin_41858"><div><strong>Erythema nodosum</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>41858</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C0014743</a></dd><dt><span class="dotprefix"></span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
<div class="spaceAbove">An erythematous eruption commonly associated with drug reactions or infection and characterized by inflammatory nodules that are usually tender, multiple, and bilateral.</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/41858">Feature record</a> | <a href="/medgen?term=%22Erythema%20nodosum%22%5BClinical%20Features%5D%20OR%2041858%5Buid%5D">Search on this feature</a></div></div>
<div class="divPopper rprt" id="clin_43961"><div><strong>Iridocyclitis</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>43961</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C0022073</a></dd><dt><span class="dotprefix"></span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
<div class="spaceAbove">A type of anterior uveitis, in which there is Inflammation of the iris and the ciliary body.</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/43961">Feature record</a> | <a href="/medgen?term=%22Iridocyclitis%22%5BClinical%20Features%5D%20OR%2043961%5Buid%5D">Search on this feature</a></div></div>
<div class="divPopper rprt" id="clin_57699"><div><strong>Oral ulcer</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>57699</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C0149745</a></dd><dt><span class="dotprefix"></span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
<div class="spaceAbove">Erosion of the mucous mebrane of the mouth with local excavation of the surface, resulting from the sloughing of inflammatory necrotic tissue.</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/57699">Feature record</a> | <a href="/medgen?term=%22Oral%20ulcer%22%5BClinical%20Features%5D%20OR%2057699%5Buid%5D">Search on this feature</a></div></div>
<div class="divPopper rprt" id="clin_11999"><div><strong>Erythema</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>11999</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C0041834</a></dd><dt><span class="dotprefix"></span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
<div class="spaceAbove">Redness of the skin, caused by hyperemia of the capillaries in the lower layers of the skin.</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/11999">Feature record</a> | <a href="/medgen?term=%22Erythema%22%5BClinical%20Features%5D%20OR%2011999%5Buid%5D">Search on this feature</a></div></div>
<div class="divPopper rprt" id="clin_350774"><div><strong>Patchy alopecia</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>350774</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C1862862</a></dd><dt><span class="dotprefix"></span></dt><dd>Finding</dd></dl></div></div></div>
<div class="spaceAbove">Transient, non-scarring hair loss and preservation of the hair follicle located in in well-defined patches.</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/350774">Feature record</a> | <a href="/medgen?term=%22Patchy%20alopecia%22%5BClinical%20Features%5D%20OR%20350774%5Buid%5D">Search on this feature</a></div></div>
<div class="divPopper rprt" id="clin_942"><div><strong>Chorioretinitis</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>942</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C0008513</a></dd><dt><span class="dotprefix"></span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
<div class="spaceAbove">An inflammation of the choroid and retina.</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/942">Feature record</a> | <a href="/medgen?term=%22Chorioretinitis%22%5BClinical%20Features%5D%20OR%20942%5Buid%5D">Search on this feature</a></div></div>
<div class="divPopper rprt" id="clin_43802"><div><strong>Hypopyon</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>43802</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C0020641</a></dd><dt><span class="dotprefix"></span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
<div class="spaceAbove">Presence of pus (appears as a white fluid) producing a fluid level in the inferior part of the anterior chamber.</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/43802">Feature record</a> | <a href="/medgen?term=%22Hypopyon%22%5BClinical%20Features%5D%20OR%2043802%5Buid%5D">Search on this feature</a></div></div>
<div class="divPopper rprt" id="clin_7160"><div><strong>Iritis</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>7160</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C0022081</a></dd><dt><span class="dotprefix"></span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
<div class="spaceAbove">Inflammation of the iris.</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/7160">Feature record</a> | <a href="/medgen?term=%22Iritis%22%5BClinical%20Features%5D%20OR%207160%5Buid%5D">Search on this feature</a></div></div><div class="TreeLite" data-jigconfig="closed: 1"><div class="concept-def"><a class="small" href="#" onclick="jQuery(&quot;.TreeLite&quot;,&quot;#ID_102&quot;).TreeLite().openAll(); return false;">Show all</a><a class="small" href="#" onclick="jQuery(&quot;.TreeLite&quot;,&quot;#ID_102&quot;).TreeLite().closeAll(); return false;">Hide all</a></div><ul><li><span class="TLline">Abnormality of blood and blood-forming tissues</span><ul><li class="TLline">
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_266934" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Superficial thrombophlebitis</a></span></li></ul></li><li><span class="TLline">Abnormality of head or neck</span><ul><li class="TLline">
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_57699" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Oral ulcer</a></span></li></ul></li><li><span class="TLline">Abnormality of the cardiovascular system</span><ul><li class="TLline">
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_20474" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Raynaud phenomenon</a></span></li></ul></li><li><span class="TLline">Abnormality of the eye</span><ul><li class="TLline">
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_942" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Chorioretinitis</a></span></li><li class="TLline">
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_43802" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Hypopyon</a></span></li><li class="TLline">
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_7160" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Iritis</a></span></li></ul></li><li><span class="TLline">Abnormality of the genitourinary system</span><ul><li class="TLline">
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_1636806" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Decreased level of D-mannose in urine</a></span></li><li class="TLline">
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_57716" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Genital ulcers</a></span></li></ul></li><li><span class="TLline">Abnormality of the immune system</span><ul><li class="TLline">
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_4986" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Epididymitis</a></span></li><li class="TLline">
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_41858" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Erythema nodosum</a></span></li><li class="TLline">
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_43961" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Iridocyclitis</a></span></li></ul></li><li><span class="TLline">Abnormality of the integument</span><ul><li class="TLline">
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_11999" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Erythema</a></span></li><li class="TLline">
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_350774" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Patchy alopecia</a></span></li></ul></li><li><span class="TLline">Abnormality of the musculoskeletal system</span><ul><li class="TLline">
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_2043" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Arthritis</a></span></li></ul></li><li><span class="TLline">Abnormality of the nervous system</span><ul><li class="TLline">
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_397841" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Irritability</a></span></li></ul></li></ul></div></div>
</div>
<div class="portlet mgSection" id="ID_118">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Term_Hierarchy">Term Hierarchy</h1><a sid="118" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln HierarchyGTR"><div class="jig-ncbitabs"><ul><li><a href="#tabGTR">GTR</a></li><li><a href="#tabMGEN">MeSH</a></li><li><a href="#tabORDO">Orphanet</a></li></ul><div id="tabGTR"><div class="search_result"><div class="rprts"><div class="chiclet_legend"><span class="chiclet_list" style="position:static;"><span title="Clinical test" class="chiclet Ccolor round">C</span><span>Clinical test,  </span><span title="Research test" class="chiclet Rcolor round">R</span><span>Research test,  </span><span title="OMIM" class="chiclet Ocolor ">O</span><span>OMIM,  </span><span title="GeneReview" class="chiclet Gcolor">G</span><span><em>GeneReviews</em>,  </span><span title="ClinVar" class="chiclet Vcolor">V</span><span>ClinVar  </span></span></div><div id="hierarchy" class="margin_t1"><div class="ds_tree"><ul><li class="matched_ds"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C0004943[DISCUI]&amp;test_type=Clinical" ref="ncbi_uid=2568">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet Ocolor" title="OMIM"><a ref="ncbi_uid=2568" target="_blank" href="/omim/109650">O</a></span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&amp;from_uid=2568" ref="ncbi_uid=2568">V</a></span></span><span class="TLline">Behcet disease</span></li></ul></div></div></div></div></div><div id="tabMGEN"><div class="ds_tree"><ul><li><span class="TLline"><a href="/medgen/4347" ref="tree=MeSH" title="MedGen record for Disease">Disease</a></span><ul><li><span class="TLline"><a href="/medgen/311052" ref="tree=MeSH" title="MedGen record for Non-Neoplastic Disorder">Non-Neoplastic Disorder</a></span><ul><li><span class="TLline"><a href="/medgen/317955" ref="tree=MeSH" title="MedGen record for Non-Neoplastic Disorder by Special Category">Non-Neoplastic Disorder by Special Category</a></span><ul><li><span class="TLline"><a href="/medgen/354119" ref="tree=MeSH" title="MedGen record for Rare Non-Neoplastic Disorder">Rare Non-Neoplastic Disorder</a></span><ul><li><span class="TLline"><a href="/medgen/45303" ref="tree=MeSH" title="MedGen record for Panuveitis">Panuveitis</a></span><ul><li><span class="TLline"><a href="/medgen/22595" ref="tree=MeSH" title="MedGen record for Anterior uveitis">Anterior uveitis</a></span><ul><li><span class="matched_ds">Behcet disease</span></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></div></div><div id="tabORDO">Follow <a target="_blank" href="http://www.orpha.net/consor/cgi-bin/Disease_Classif.php?lng=EN&amp;data_id=156&amp;PatId=703&amp;search=Disease_Classif_Simple&amp;new=1" class="ital bold">this link</a> to review classifications for <span class="ital">Behcet disease</span> in Orphanet.</div></div></div>
</div>
<div class="portlet mgSection" id="ID_105">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Professional_guidelines">Professional guidelines</h1><a sid="105" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln"><h3 class="subhead">PubMed<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpPM"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3>
<div class="nl"><a target="_blank" href="/pubmed/34715076">Comment on "Classification Criteria for Behçet Disease Uveitis".</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Tugal-Tutkun I,
Onal S,
Gül A</span><br />
<span class="medgenPMjournal">Am J Ophthalmol</span>
2022 Mar;235:336-338.
Epub 2021 Oct 27
doi: 10.1016/j.ajo.2021.07.036.
<span class="bold">PMID: </span><a href="/pubmed/34715076" target="_blank">34715076</a></div>
<div class="nl"><a target="_blank" href="/pubmed/33845008">Classification Criteria for Behçet Disease Uveitis.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Standardization of Uveitis Nomenclature (SUN) Working Group</span><br />
<span class="medgenPMjournal">Am J Ophthalmol</span>
2021 Aug;228:80-88.
Epub 2021 May 11
doi: 10.1016/j.ajo.2021.03.058.
<span class="bold">PMID: </span><a href="/pubmed/33845008" target="_blank">33845008</a><a href="/pmc/articles/PMC8545705" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/29977929">Autoimmune Diseases and Their Manifestations on Oral Cavity: Diagnosis and Clinical Management.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Saccucci M,
Di Carlo G,
Bossù M,
Giovarruscio F,
Salucci A,
Polimeni A</span><br />
<span class="medgenPMjournal">J Immunol Res</span>
2018;2018:6061825.
Epub 2018 May 27
doi: 10.1155/2018/6061825.
<span class="bold">PMID: </span><a href="/pubmed/29977929" target="_blank">29977929</a><a href="/pmc/articles/PMC5994274" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(%22behcet%20disease%22%5Btiab%3A~0%5D)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">See all (76)</a></div></div>
</div>
<div class="display-none help-popup" id="guidelinesHelpPM">These guidelines are articles in PubMed that match specific search criteria developed by MedGen to capture the most relevant practice guidelines. This list may not be comprehensive and may include broader topics as well. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div><div class="display-none help-popup" id="guidelinesHelpCurated">These guidelines are manually curated by the MedGen team
to supplement articles available in PubMed. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div>
<div class="portlet mgSection" id="ID_103">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_clinical_studies">Recent clinical studies</h1><a sid="103" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln"><h3 class="subhead">Etiology</h3>
<div class="nl"><a target="_blank" href="/pubmed/33683567">Erythema Nodosum: A Practical Approach and Diagnostic Algorithm.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Pérez-Garza DM,
Chavez-Alvarez S,
Ocampo-Candiani J,
Gomez-Flores M</span><br />
<span class="medgenPMjournal">Am J Clin Dermatol</span>
2021 May;22(3):367-378.
Epub 2021 Mar 8
doi: 10.1007/s40257-021-00592-w.
<span class="bold">PMID: </span><a href="/pubmed/33683567" target="_blank">33683567</a><a href="/pmc/articles/PMC7938036" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/31375286">Aseptic meningitis.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Tattevin P,
Tchamgoué S,
Belem A,
Bénézit F,
Pronier C,
Revest M</span><br />
<span class="medgenPMjournal">Rev Neurol (Paris)</span>
2019 Sep-Oct;175(7-8):475-480.
Epub 2019 Jul 30
doi: 10.1016/j.neurol.2019.07.005.
<span class="bold">PMID: </span><a href="/pubmed/31375286" target="_blank">31375286</a></div>
<div class="nl"><a target="_blank" href="/pubmed/28390566">Vasculitis and Pregnancy.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Machen L,
Clowse ME</span><br />
<span class="medgenPMjournal">Rheum Dis Clin North Am</span>
2017 May;43(2):239-247.
Epub 2017 Mar 15
doi: 10.1016/j.rdc.2016.12.005.
<span class="bold">PMID: </span><a href="/pubmed/28390566" target="_blank">28390566</a></div>
<div class="nl"><a target="_blank" href="/pubmed/25852265">Gastrointestinal Behçet's disease: a review.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Skef W,
Hamilton MJ,
Arayssi T</span><br />
<span class="medgenPMjournal">World J Gastroenterol</span>
2015 Apr 7;21(13):3801-12.
doi: 10.3748/wjg.v21.i13.3801.
<span class="bold">PMID: </span><a href="/pubmed/25852265" target="_blank">25852265</a><a href="/pmc/articles/PMC4385527" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/24655523">Recurrent aphthous stomatitis.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Akintoye SO,
Greenberg MS</span><br />
<span class="medgenPMjournal">Dent Clin North Am</span>
2014 Apr;58(2):281-97.
Epub 2014 Jan 21
doi: 10.1016/j.cden.2013.12.002.
<span class="bold">PMID: </span><a href="/pubmed/24655523" target="_blank">24655523</a><a href="/pmc/articles/PMC3964366" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Behcet%20disease%22%20AND%20Etiology%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (547)</a></div><h3 class="subhead">Diagnosis</h3>
<div class="nl"><a target="_blank" href="/pubmed/38955656">Genetics of vasculitis.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">González-Gay MÁ,
Heras-Recuero E,
Blázquez-Sánchez T,
Caraballo-Salazar C,
Rengifo-García F,
Castañeda S,
Martín J,
Marquez A,
Largo R</span><br />
<span class="medgenPMjournal">Best Pract Res Clin Rheumatol</span>
2024 Dec;38(4):101969.
Epub 2024 Jul 2
doi: 10.1016/j.berh.2024.101969.
<span class="bold">PMID: </span><a href="/pubmed/38955656" target="_blank">38955656</a></div>
<div class="nl"><a target="_blank" href="/pubmed/31375286">Aseptic meningitis.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Tattevin P,
Tchamgoué S,
Belem A,
Bénézit F,
Pronier C,
Revest M</span><br />
<span class="medgenPMjournal">Rev Neurol (Paris)</span>
2019 Sep-Oct;175(7-8):475-480.
Epub 2019 Jul 30
doi: 10.1016/j.neurol.2019.07.005.
<span class="bold">PMID: </span><a href="/pubmed/31375286" target="_blank">31375286</a></div>
<div class="nl"><a target="_blank" href="/pubmed/29977929">Autoimmune Diseases and Their Manifestations on Oral Cavity: Diagnosis and Clinical Management.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Saccucci M,
Di Carlo G,
Bossù M,
Giovarruscio F,
Salucci A,
Polimeni A</span><br />
<span class="medgenPMjournal">J Immunol Res</span>
2018;2018:6061825.
Epub 2018 May 27
doi: 10.1155/2018/6061825.
<span class="bold">PMID: </span><a href="/pubmed/29977929" target="_blank">29977929</a><a href="/pmc/articles/PMC5994274" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/28916023">Behçet disease: New aspects.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Bulur I,
Onder M</span><br />
<span class="medgenPMjournal">Clin Dermatol</span>
2017 Sep-Oct;35(5):421-434.
Epub 2017 Jun 27
doi: 10.1016/j.clindermatol.2017.06.004.
<span class="bold">PMID: </span><a href="/pubmed/28916023" target="_blank">28916023</a></div>
<div class="nl"><a target="_blank" href="/pubmed/28129926">Panniculitis: A summary.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Wick MR</span><br />
<span class="medgenPMjournal">Semin Diagn Pathol</span>
2017 May;34(3):261-272.
Epub 2016 Dec 27
doi: 10.1053/j.semdp.2016.12.004.
<span class="bold">PMID: </span><a href="/pubmed/28129926" target="_blank">28129926</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Behcet%20disease%22%20AND%20Diagnosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (668)</a></div><h3 class="subhead">Therapy</h3>
<div class="nl"><a target="_blank" href="/pubmed/38937151">Neuro-Behçet's disease: A review.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Belfeki N,
Ghriss N,
Fourati M,
Leclercq D,
Saadoun D</span><br />
<span class="medgenPMjournal">Rev Med Interne</span>
2024 Oct;45(10):624-633.
Epub 2024 Jun 26
doi: 10.1016/j.revmed.2024.06.007.
<span class="bold">PMID: </span><a href="/pubmed/38937151" target="_blank">38937151</a></div>
<div class="nl"><a target="_blank" href="/pubmed/38402885">Behçet's syndrome.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Emmi G,
Bettiol A,
Hatemi G,
Prisco D</span><br />
<span class="medgenPMjournal">Lancet</span>
2024 Mar 16;403(10431):1093-1108.
Epub 2024 Feb 22
doi: 10.1016/S0140-6736(23)02629-6.
<span class="bold">PMID: </span><a href="/pubmed/38402885" target="_blank">38402885</a></div>
<div class="nl"><a target="_blank" href="/pubmed/33683567">Erythema Nodosum: A Practical Approach and Diagnostic Algorithm.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Pérez-Garza DM,
Chavez-Alvarez S,
Ocampo-Candiani J,
Gomez-Flores M</span><br />
<span class="medgenPMjournal">Am J Clin Dermatol</span>
2021 May;22(3):367-378.
Epub 2021 Mar 8
doi: 10.1007/s40257-021-00592-w.
<span class="bold">PMID: </span><a href="/pubmed/33683567" target="_blank">33683567</a><a href="/pmc/articles/PMC7938036" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/28390566">Vasculitis and Pregnancy.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Machen L,
Clowse ME</span><br />
<span class="medgenPMjournal">Rheum Dis Clin North Am</span>
2017 May;43(2):239-247.
Epub 2017 Mar 15
doi: 10.1016/j.rdc.2016.12.005.
<span class="bold">PMID: </span><a href="/pubmed/28390566" target="_blank">28390566</a></div>
<div class="nl"><a target="_blank" href="/pubmed/18793988">Subcutaneous sweet syndrome.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Guhl G,
García-Díez A</span><br />
<span class="medgenPMjournal">Dermatol Clin</span>
2008 Oct;26(4):541-51, viii-ix.
doi: 10.1016/j.det.2008.06.003.
<span class="bold">PMID: </span><a href="/pubmed/18793988" target="_blank">18793988</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Behcet%20disease%22%20AND%20Therapy%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (381)</a></div><h3 class="subhead">Prognosis</h3>
<div class="nl"><a target="_blank" href="/pubmed/38955656">Genetics of vasculitis.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">González-Gay MÁ,
Heras-Recuero E,
Blázquez-Sánchez T,
Caraballo-Salazar C,
Rengifo-García F,
Castañeda S,
Martín J,
Marquez A,
Largo R</span><br />
<span class="medgenPMjournal">Best Pract Res Clin Rheumatol</span>
2024 Dec;38(4):101969.
Epub 2024 Jul 2
doi: 10.1016/j.berh.2024.101969.
<span class="bold">PMID: </span><a href="/pubmed/38955656" target="_blank">38955656</a></div>
<div class="nl"><a target="_blank" href="/pubmed/38402885">Behçet's syndrome.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Emmi G,
Bettiol A,
Hatemi G,
Prisco D</span><br />
<span class="medgenPMjournal">Lancet</span>
2024 Mar 16;403(10431):1093-1108.
Epub 2024 Feb 22
doi: 10.1016/S0140-6736(23)02629-6.
<span class="bold">PMID: </span><a href="/pubmed/38402885" target="_blank">38402885</a></div>
<div class="nl"><a target="_blank" href="/pubmed/33683567">Erythema Nodosum: A Practical Approach and Diagnostic Algorithm.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Pérez-Garza DM,
Chavez-Alvarez S,
Ocampo-Candiani J,
Gomez-Flores M</span><br />
<span class="medgenPMjournal">Am J Clin Dermatol</span>
2021 May;22(3):367-378.
Epub 2021 Mar 8
doi: 10.1007/s40257-021-00592-w.
<span class="bold">PMID: </span><a href="/pubmed/33683567" target="_blank">33683567</a><a href="/pmc/articles/PMC7938036" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/29977929">Autoimmune Diseases and Their Manifestations on Oral Cavity: Diagnosis and Clinical Management.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Saccucci M,
Di Carlo G,
Bossù M,
Giovarruscio F,
Salucci A,
Polimeni A</span><br />
<span class="medgenPMjournal">J Immunol Res</span>
2018;2018:6061825.
Epub 2018 May 27
doi: 10.1155/2018/6061825.
<span class="bold">PMID: </span><a href="/pubmed/29977929" target="_blank">29977929</a><a href="/pmc/articles/PMC5994274" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/25852265">Gastrointestinal Behçet's disease: a review.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Skef W,
Hamilton MJ,
Arayssi T</span><br />
<span class="medgenPMjournal">World J Gastroenterol</span>
2015 Apr 7;21(13):3801-12.
doi: 10.3748/wjg.v21.i13.3801.
<span class="bold">PMID: </span><a href="/pubmed/25852265" target="_blank">25852265</a><a href="/pmc/articles/PMC4385527" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Behcet%20disease%22%20AND%20Prognosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (303)</a></div><h3 class="subhead">Clinical prediction guides</h3>
<div class="nl"><a target="_blank" href="/pubmed/38402885">Behçet's syndrome.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Emmi G,
Bettiol A,
Hatemi G,
Prisco D</span><br />
<span class="medgenPMjournal">Lancet</span>
2024 Mar 16;403(10431):1093-1108.
Epub 2024 Feb 22
doi: 10.1016/S0140-6736(23)02629-6.
<span class="bold">PMID: </span><a href="/pubmed/38402885" target="_blank">38402885</a></div>
<div class="nl"><a target="_blank" href="/pubmed/35082168">Progranulin Suppressed Autoimmune Uveitis and Autoimmune Neuroinflammation by Inhibiting Th1/Th17 Cells and Promoting Treg Cells and M2 Macrophages.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Wang C,
Zhou W,
Su G,
Hu J,
Yang P</span><br />
<span class="medgenPMjournal">Neurol Neuroimmunol Neuroinflamm</span>
2022 Mar;9(2)
Epub 2022 Jan 26
doi: 10.1212/NXI.0000000000001133.
<span class="bold">PMID: </span><a href="/pubmed/35082168" target="_blank">35082168</a><a href="/pmc/articles/PMC8791655" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/31689818">Risk of malignancy in Behcet disease: A meta-analysis with systematic review.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Wang X,
Peng Y,
Gao J,
Han S,
Li Y</span><br />
<span class="medgenPMjournal">Medicine (Baltimore)</span>
2019 Nov;98(44):e17735.
doi: 10.1097/MD.0000000000017735.
<span class="bold">PMID: </span><a href="/pubmed/31689818" target="_blank">31689818</a><a href="/pmc/articles/PMC6946361" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/30809980">The Platelet-to-Lymphocyte Ratio as an Inflammatory Marker in Rheumatic Diseases.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Gasparyan AY,
Ayvazyan L,
Mukanova U,
Yessirkepov M,
Kitas GD</span><br />
<span class="medgenPMjournal">Ann Lab Med</span>
2019 Jul;39(4):345-357.
doi: 10.3343/alm.2019.39.4.345.
<span class="bold">PMID: </span><a href="/pubmed/30809980" target="_blank">30809980</a><a href="/pmc/articles/PMC6400713" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/25852265">Gastrointestinal Behçet's disease: a review.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Skef W,
Hamilton MJ,
Arayssi T</span><br />
<span class="medgenPMjournal">World J Gastroenterol</span>
2015 Apr 7;21(13):3801-12.
doi: 10.3748/wjg.v21.i13.3801.
<span class="bold">PMID: </span><a href="/pubmed/25852265" target="_blank">25852265</a><a href="/pmc/articles/PMC4385527" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Behcet%20disease%22%20AND%20Clinical%20prediction%20guides%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (283)</a></div></div>
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_systematic_reviews">Recent systematic reviews</h1><a sid="104" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln">
<div class="nl"><a target="_blank" href="/pubmed/37661116">Behçet disease in Latin American countries: A systematic literature review of demographic and clinical features, and HLA-B*51 allele frequency.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Muñoz SA,
Kostianovsky A,
Allievi A,
Orden AO</span><br />
<span class="medgenPMjournal">Reumatol Clin (Engl Ed)</span>
2023 Aug-Sep;19(7):386-391.
doi: 10.1016/j.reumae.2022.12.005.
<span class="bold">PMID: </span><a href="/pubmed/37661116" target="_blank">37661116</a></div>
<div class="nl"><a target="_blank" href="/pubmed/35342952">Risk of ischaemic heart diseases and stroke in behçet disease: A systematic review and meta-analysis.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Chuang KW,
Chang HC</span><br />
<span class="medgenPMjournal">Eur J Clin Invest</span>
2022 Aug;52(8):e13778.
Epub 2022 Apr 5
doi: 10.1111/eci.13778.
<span class="bold">PMID: </span><a href="/pubmed/35342952" target="_blank">35342952</a></div>
<div class="nl"><a target="_blank" href="/pubmed/31689818">Risk of malignancy in Behcet disease: A meta-analysis with systematic review.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Wang X,
Peng Y,
Gao J,
Han S,
Li Y</span><br />
<span class="medgenPMjournal">Medicine (Baltimore)</span>
2019 Nov;98(44):e17735.
doi: 10.1097/MD.0000000000017735.
<span class="bold">PMID: </span><a href="/pubmed/31689818" target="_blank">31689818</a><a href="/pmc/articles/PMC6946361" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/29890348">Autosomic dominant familial Behçet disease and haploinsufficiency A20: A review of the literature.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Berteau F,
Rouviere B,
Delluc A,
Nau A,
Le Berre R,
Sarrabay G,
Touitou I,
de Moreuil C</span><br />
<span class="medgenPMjournal">Autoimmun Rev</span>
2018 Aug;17(8):809-815.
Epub 2018 Jun 8
doi: 10.1016/j.autrev.2018.02.012.
<span class="bold">PMID: </span><a href="/pubmed/29890348" target="_blank">29890348</a></div>
<div class="nl"><a target="_blank" href="/pubmed/26239908">Subclinical atherosclerosis in Behcet's disease: A systematic review and meta-analysis.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Merashli M,
Ster IC,
Ames PR</span><br />
<span class="medgenPMjournal">Semin Arthritis Rheum</span>
2016 Feb;45(4):502-10.
Epub 2015 Jul 4
doi: 10.1016/j.semarthrit.2015.06.018.
<span class="bold">PMID: </span><a href="/pubmed/26239908" target="_blank">26239908</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Behcet%20disease%22%20AND%20systematic%5Bsb%5D%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (17)</a></div></div>
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Table_of_contents">Table of contents</h1><a sid="113" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln"><ul id="my-toc"></ul></div>
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<div class="portlet_content ln"><ul><li><a href="/gtr/tests?term=C0004943%5bDISCUI%5d&amp;filter=method%3A2%5F7" target="_blank">Sequence analysis of the entire coding region (1)</a></li>
<li><a href="/gtr/tests?term=C0004943%5bDISCUI%5d&amp;filter=method%3A2%5F19" target="_blank">Targeted variant analysis (2)</a></li>
<li class="portletSeeAll portletSeeAllPad"><total><a href="/gtr/tests?term=C0004943%5bDISCUI%5d" target="_blank">See all (3)</a></total></li>
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<div class="portlet_content ln"><ul><li><a href="https://www.omim.org/search?index=entry&amp;start=1&amp;limit=10&amp;sort=score%20desc&amp;field=number&amp;search=109650" target="_blank">OMIM</a></li><li><a href="http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Expert=117" target="_blank">Orphanet</a></li><li><a href="https://clinicaltrials.gov/search?cond=Behcet%20disease" target="_blank">ClinicalTrials.gov</a></li></ul></div>
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