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<meta name="keywords" content="C0004245, atrioventricular block, atrioventricular block (disease), atrioventricular block by ecg finding, atrioventricular block by ekg finding, atrioventricular blocks, atrioventricular conduction block, atrioventricular conduction blocks, atrioventricular nodal disease, av block, av blocks, av nodal block, avb, avb - atrioventricular block, block, av, blocks, av, conduction block, atrioventricular, conduction blocks, atrioventricular, disease or syndrome, interruption of electrical communication between upper and lower chambers of heart, autosomal dominant, autosomal recessive, birth defects, chromosomal disease, chromosome, clinical features, clinical findings, clinical genetics, clinical recommendations, clinvar, congenital chromosomal disease, consumer genetic resources, cytogenetic location, disease characteristics, disease definitions, disease descriptions, disease ontology, disease synonyms, disease vocabulary, dysmorphology, entrez, familial disease, gene, gene-disease relationship, genereviews, genetic disease, genetic disorder, genetic terminology, genetic testing registry, genetics home reference, genomic disease, gtr, hereditary disease, heritable disease, hpo, human phenotype ontology, inherited disease, management guidelines, maternal inheritance, medgen, medical genetics, medical subject headings, mesh, mitochondrial inheritance, mode of inheritance, national center for biotechnology information, national institutes of health, national library of medicine, ncbi, nih, nlm, omim, ordo, orphanet, paternal inheritance, phenome, position statements, professional practice guidelines, rare disease, reference sequence, refseq, snomed ct, syndrome, undiagnosed diseases, x-linked recessive" /><meta name="description" content="Delayed or lack of conduction of atrial depolarizations through the atrioventricular node to the ventricles." /><meta name="robots" content="index,nofollow,noarchive" />
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<!--
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||
UID=13956
|
||
ConceptID=C0004245
|
||
-->
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||
<!--imgCountBooks = 0--><h1 class="medgenTitle"><div class="MedGenTitleText">Atrioventricular block</div></h1><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>13956</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information."><span class="highlight" style="background-color:">C0004245</span></a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div><table class="medgenTable"><tbody><tr><td>Synonyms:</td>
|
||
<td>Atrioventricular conduction block; AV block</td></tr>
|
||
<tr><td><span class="bold">SNOMED CT: </span></td>
|
||
<td>AVB - Atrioventricular block (233917008); AV block (233917008); Atrioventricular block (233917008)</td></tr>
|
||
<tr><td colspan="2" class="small"> </td></tr><tr><td>HPO:</td>
|
||
<td><a target="_blank" title="Human Phenotype Ontology" href="https://hpo.jax.org/app/browse/term/HP:0001678">HP:0001678</a></td></tr>
|
||
<tr><td>Monarch Initiative:</td>
|
||
<td><a href="https://monarchinitiative.org/disease/MONDO:0000465" target="_blank">MONDO:0000465</a></td></tr>
|
||
</tbody></table></div><div class="rprt-body jig-ncbiinpagenav" data-jigconfig="smoothScroll: false, gotoTopLink: true, gotoTopLinkText: '', gotoTopLinkAttrs: {'title': 'Go to the top of the page'},allHeadingLevels: ['h1'], topOfPageTOC: true, tocId: 'my-toc'"><div id="rprt-tabs-1" class="rprt-tab"><div id="tb-termsProp-1"><div class="leftCol mgCol"><div>
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<div class="portlet mgSection" id="ID_100">
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||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Definition">Definition</h1><a sid="100" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln">Delayed or lack of conduction of atrial depolarizations through the atrioventricular node to the ventricles. [from <a title="Human Phenotype Ontology" href="http://www.human-phenotype-ontology.org" class="defSource" target="_blank">HPO</a>]</div>
|
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</div>
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<div class="portlet mgSection" id="ID_118">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Term_Hierarchy">Term Hierarchy</h1><a sid="118" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln HierarchyGTR"><div class="jig-ncbitabs"><ul><li><a href="#tabGTR">GTR</a></li><li><a href="#tabMGEN">MeSH</a></li></ul><div id="tabGTR"><div class="search_result"><div class="rprts"><div class="chiclet_legend"><span class="chiclet_list" style="position:static;"><span title="Clinical test" class="chiclet Ccolor round">C</span><span>Clinical test, </span><span title="Research test" class="chiclet Rcolor round">R</span><span>Research test, </span><span title="OMIM" class="chiclet Ocolor ">O</span><span>OMIM, </span><span title="GeneReview" class="chiclet Gcolor">G</span><span><em>GeneReviews</em>, </span><span title="ClinVar" class="chiclet Vcolor">V</span><span>ClinVar </span></span></div><div id="hierarchy" class="margin_t1"><div class="ds_tree"><ul><li class="matched_ds"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C0004245[DISCUI]&test_type=Clinical" ref="ncbi_uid=13956">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet unavailable" title="OMIM">O</span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&from_uid=13956" ref="ncbi_uid=13956">V</a></span></span><span class="TLline">Atrioventricular block</span></li></ul></div></div></div></div></div><div id="tabMGEN"><div class="ds_tree"><ul><li><span class="TLline"><a href="/medgen/2848" ref="tree=MeSH" title="MedGen record for Disorder of cardiovascular system">Disorder of cardiovascular system</a></span><ul><li><span class="TLline"><a href="/medgen/116727" ref="tree=MeSH" title="MedGen record for Abnormality of the cardiovascular system">Abnormality of the cardiovascular system</a></span><ul><li><span class="TLline"><a href="/medgen/869166" ref="tree=MeSH" title="MedGen record for Abnormal cardiovascular system physiology">Abnormal cardiovascular system physiology</a></span><ul><li><span class="TLline"><a href="/medgen/1393551" ref="tree=MeSH" title="MedGen record for Abnormality of cardiovascular system electrophysiology">Abnormality of cardiovascular system electrophysiology</a></span><ul><li><span class="TLline"><a href="/medgen/2039" ref="tree=MeSH" title="MedGen record for Cardiac arrhythmia">Cardiac arrhythmia</a></span><ul><li><span class="TLline"><a href="/medgen/42363" ref="tree=MeSH" title="MedGen record for Heart block">Heart block</a></span><ul><li><span class="matched_ds">Atrioventricular block</span><ul><li><span class="TLline"><a href="/medgen/384561" ref="tree=MeSH" title="MedGen record for 2:1 Atrioventricular Block by ECG Finding">2:1 Atrioventricular Block by ECG Finding</a></span></li><li><span class="TLline"><a href="/medgen/870558" ref="tree=MeSH" title="MedGen record for Absent atrioventricular node">Absent atrioventricular node</a></span></li><li><span class="TLline"><a href="/medgen/811633" ref="tree=MeSH" title="MedGen record for AV Block First Degree by ECG Finding">AV Block First Degree by ECG Finding</a></span></li><li><span class="TLline"><a href="/medgen/811441" ref="tree=MeSH" title="MedGen record for AV Block Second Degree by ECG Finding">AV Block Second Degree by ECG Finding</a></span><ul><li><span class="TLline"><a href="/medgen/817654" ref="tree=MeSH" title="MedGen record for AV Block Second Degree Mobitz Type I by ECG Finding">AV Block Second Degree Mobitz Type I by ECG Finding</a></span></li><li><span class="TLline"><a href="/medgen/817655" ref="tree=MeSH" title="MedGen record for AV Block Second Degree Mobitz Type II by ECG Finding">AV Block Second Degree Mobitz Type II by ECG Finding</a></span></li><li><span class="TLline"><a href="/medgen/760522" ref="tree=MeSH" title="MedGen record for High Grade Atrioventricular Block by ECG Finding">High Grade Atrioventricular Block by ECG Finding</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/776576" ref="tree=MeSH" title="MedGen record for AV Block Third Degree by ECG Finding">AV Block Third Degree by ECG Finding</a></span></li><li><span class="TLline"><a href="/medgen/43215" ref="tree=MeSH" title="MedGen record for First degree atrioventricular block">First degree atrioventricular block</a></span></li><li><span class="TLline"><a href="/medgen/364173" ref="tree=MeSH" title="MedGen record for Paroxysmal Atrioventricular Block by ECG Finding">Paroxysmal Atrioventricular Block by ECG Finding</a></span></li><li><span class="TLline"><a href="/medgen/75546" ref="tree=MeSH" title="MedGen record for Second degree atrioventricular block">Second degree atrioventricular block</a></span><ul><li><span class="TLline"><a href="/medgen/1716161" ref="tree=MeSH" title="MedGen record for 2:1 atrioventricular block">2:1 atrioventricular block</a></span></li><li><span class="TLline"><a href="/medgen/82687" ref="tree=MeSH" title="MedGen record for Mobitz I atrioventricular block">Mobitz I atrioventricular block</a></span></li><li><span class="TLline"><a href="/medgen/102340" ref="tree=MeSH" title="MedGen record for Mobitz II atrioventricular block">Mobitz II atrioventricular block</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/56230" ref="tree=MeSH" title="MedGen record for Third degree atrioventricular block">Third degree atrioventricular block</a></span><ul><li><span class="TLline"><a href="/medgen/1391206" ref="tree=MeSH" title="MedGen record for Complete heart block with broad QRS complexes">Complete heart block with broad QRS complexes</a></span></li><li><span class="TLline"><a href="/medgen/331099" ref="tree=MeSH" title="MedGen record for Complete heart block with narrow QRS complexes">Complete heart block with narrow QRS complexes</a></span></li><li><span class="TLline"><a href="/medgen/473062" ref="tree=MeSH" title="MedGen record for Congenital complete atrioventricular heart block">Congenital complete atrioventricular heart block</a></span></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></div></div></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_112">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Conditions_with_this_feature">Conditions with this feature</h1><a sid="112" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln clinfeat">
|
||
<div class="divPopper rprt" id="rdis_57432"><div><strong>Congenital heart block</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>57432</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0149530</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Congenital heart block (CHB) is a rare disorder of atrioventricular conduction, characterized by absence of conduction of atrial impulses to the ventricles with slower ventricular rhythm (atrioventricular dissociation). CHB can occur in association with immunological evidence of maternal connective disease (autoimmune CHD), fetal structural CHD or can be idiopathic.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/57432">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_75658"><div><strong>Primary hyperoxaluria, type I</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>75658</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0268164</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Primary hyperoxaluria type 1 (PH1) is caused by deficiency of the liver peroxisomal enzyme alanine-glyoxylate aminotransferase (AGT), which catalyzes the conversion of glyoxylate to glycine. When AGT activity is reduced or absent, glyoxylate is converted to oxalate, which cannot be metabolized and must be excreted by the kidneys. Insoluble calcium oxalate crystals form due to high urinary oxalate concentration. Urinary crystals aggregate, leading to nephrolithiasis (i.e., calcium oxalate kidney stones) in the renal pelvis / urinary tract; often the crystals deposit in kidney parenchyma (nephrocalcinosis). The age at presentation of PH1 ranges from infancy (age <12 months) in 10% of individuals, childhood/adolescence (age 1-17 years) in 70%, and adulthood (age =18 years) in 20%. The natural history of untreated PH1 is (1) progressive decline in kidney function due to complications of nephrolithiasis (e.g., urinary obstruction, infection) and nephrocalcinosis, and (2) in persons with advanced chronic kidney disease (CKD), high plasma oxalate concentrations result in other organ and tissue damage from calcium oxalate deposition (i.e., "oxalosis"), most commonly in the bones, heart, and retina. In the absence of treatment, progression of oxalosis results in death from kidney failure and/or other organ involvement.</div>
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<div class="spaceAbove nowrap">See: <a href="/medgen/75658">Condition Record</a></div></div>
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||
<div class="divPopper rprt" id="rdis_91000"><div><strong>Carnitine acylcarnitine translocase deficiency</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>91000</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0342791</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
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<div class="spaceAbove">Carnitine-acylcarnitine translocase (CACT) is a critical component of the carnitine shuttle, which facilitates the transfer of long-chain fatty acylcarnitines across the inner mitochondrial membrane. CACT deficiency causes a defect in mitochondrial long-chain fatty acid ß-oxidation, with variable clinical severity. Severe neonatal-onset disease is most common, with symptoms evident within two days after birth; attenuated cases may present in the first months of life. Hyperammonemia and cardiac arrhythmia are prominent in early-onset disease, with high rates of cardiac arrest. Other clinical features are typical for disorders of long-chain fatty acid oxidation: poor feeding, lethargy, hypoketotic hypoglycemia, hypotonia, transaminitis, liver dysfunction with hepatomegaly, and rhabdomyolysis. Univentricular or biventricular hypertrophic cardiomyopathy, ranging from mild to severe, may respond to appropriate dietary and medical therapies. Hyperammonemia is difficult to treat and is an important determinant of long-term neurocognitive outcome. Affected individuals with early-onset disease typically experience brain injury at presentation, and have recurrent hyperammonemia leading to developmental delay / intellectual disability. Affected individuals with later-onset disease have milder symptoms and are less likely to experience recurrent hyperammonemia, allowing a better developmental outcome. Prompt treatment of the presenting episode to prevent hypoglycemic, hypoxic, or hyperammonemic brain injury may allow normal growth and development.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/91000">Condition Record</a></div></div>
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||
<div class="divPopper rprt" id="rdis_209235"><div><strong>Danon disease</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>209235</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0878677</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Danon disease is a multisystem condition with predominant involvement of the heart, skeletal muscles, and retina, with overlying cognitive dysfunction. Males are typically more severely affected than females. Males usually present with childhood onset concentric hypertrophic cardiomyopathy that is progressive and often requires heart transplantation. Rarely, hypertrophic cardiomyopathy can evolve to resemble dilated cardiomyopathy. Most affected males also have cardiac conduction abnormalities. Skeletal muscle weakness may lead to delayed acquisition of motor milestones. Learning disability and intellectual disability, most often in the mild range, are common. Additionally, affected males can develop retinopathy with subsequent visual impairment. The clinical features in females are broader and more variable. Females are more likely to have dilated cardiomyopathy, with a smaller proportion requiring heart transplantation compared to affected males. Cardiac conduction abnormalities, skeletal muscle weakness, mild cognitive impairment, and pigmentary retinopathy are variably seen in affected females.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/209235">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_351513"><div><strong>Catecholaminergic polymorphic ventricular tachycardia 1</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>351513</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1631597</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Catecholaminergic polymorphic ventricular tachycardia (CPVT) is characterized by episodic syncope occurring during exercise or acute emotion. The underlying cause of these episodes is the onset of fast ventricular tachycardia (bidirectional or polymorphic). Spontaneous recovery may occur when these arrhythmias self-terminate. In other instances, ventricular tachycardia may degenerate into ventricular fibrillation and cause sudden death if cardiopulmonary resuscitation is not readily available. The mean onset of symptoms (usually a syncopal episode) is between age seven and 12 years; onset as late as the fourth decade of life has been reported. If untreated, CPVT is highly lethal, as approximately 30% of affected individuals experience at least one cardiac arrest and up to 80% have one or more syncopal spells. Sudden death may be the first manifestation of the disease.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/351513">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_354526"><div><strong>Familial partial lipodystrophy, Dunnigan type</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>354526</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1720860</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
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||
<div class="spaceAbove">Familial partial lipodystrophy (FPLD) is a metabolic disorder characterized by abnormal subcutaneous adipose tissue distribution beginning in late childhood or early adult life. Affected individuals gradually lose fat from the upper and lower extremities and the gluteal and truncal regions, resulting in a muscular appearance with prominent superficial veins. In some patients, adipose tissue accumulates on the face and neck, causing a double chin, fat neck, or cushingoid appearance. Metabolic abnormalities include insulin-resistant diabetes mellitus with acanthosis nigricans and hypertriglyceridemia; hirsutism and menstrual abnormalities occur infrequently. Familial partial lipodystrophy may also be referred to as lipoatrophic diabetes mellitus, but the essential feature is loss of subcutaneous fat (review by Garg, 2004). The disorder may be misdiagnosed as Cushing disease (see 219080) (Kobberling and Dunnigan, 1986; Garg, 2004). Genetic Heterogeneity of Familial Partial Lipodystrophy Familial partial lipodystrophy is a clinically and genetically heterogeneous disorder. Types 1 and 2 were originally described as clinical subtypes: type 1 (FPLD1; 608600), characterized by loss of subcutaneous fat confined to the limbs (Kobberling et al., 1975), and FPLD2, characterized by loss of subcutaneous fat from the limbs and trunk (Dunnigan et al., 1974; Kobberling and Dunnigan, 1986). No genetic basis for FPLD1 has yet been delineated. FPLD3 (604367) is caused by mutation in the PPARG gene (601487) on chromosome 3p25; FPLD4 (613877) is caused by mutation in the PLIN1 gene (170290) on chromosome 15q26; FPLD5 (615238) is caused by mutation in the CIDEC gene (612120) on chromosome 3p25; FPLD6 (615980) is caused by mutation in the LIPE gene (151750) on chromosome 19q13; FPLD7 (606721) is caused by mutation in the CAV1 gene (601047) on chromosome 7q31; FPLD8 (620679), caused by mutation in the ADRA2A gene (104210) on chromosome 10q25; and FPLD9 (620683), caused by mutation in the PLAAT3 gene (613867) on chromosome 11q12.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/354526">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_331341"><div><strong>Dilated cardiomyopathy 1E</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>331341</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1832680</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
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||
<div class="spaceAbove">Any familial isolated dilated cardiomyopathy in which the cause of the disease is a mutation in the SCN5A gene.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/331341">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_331395"><div><strong>Timothy syndrome</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>331395</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1832916</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">The clinical manifestations of CACNA1C-related disorders include a spectrum of nonsyndromic and syndromic phenotypes, which generally correlate with the impact of the pathogenic variant on calcium current. Phenotypes can include nonsyndromic long QT syndrome (rate-corrected QT [QTc] interval >480 ms); nonsyndromic short QT syndrome (QTc <350 ms), with risk of sudden death; Brugada syndrome (ST segment elevation in right precordial leads [V1-V2]) with short QT interval; classic Timothy syndrome (prolonged QT interval, autism, and congenital heart defect) with or without unilateral or bilateral cutaneous syndactyly variably involving fingers two (index), three (middle), four (ring), and five (little) and bilateral cutaneous syndactyly of toes two and three; and CACNA1C-related neurodevelopmental disorder, in which the features tend to favor one or more of the following: developmental delay / intellectual disability, hypotonia, epilepsy, and/or ataxia.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/331395">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_331466"><div><strong>Hypertrophic cardiomyopathy 6</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>331466</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1833236</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Mutations in the PRKAG2 gene (602743) give rise to a moderate, essentially heart-specific, nonlysosomal glycogenosis with clinical onset typically in late adolescence or in the third decade of life, ventricular pre-excitation predisposing to supraventricular arrhythmias, mild to severe cardiac hypertrophy, enhanced risk of sudden cardiac death in midlife, and autosomal dominant inheritance with full penetrance (summary by Burwinkel et al., 2005).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/331466">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_325270"><div><strong>Sick sinus syndrome 1</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>325270</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1837845</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">The term 'sick sinus syndrome' encompasses a variety of conditions caused by sinus node dysfunction. The most common clinical manifestations are syncope, presyncope, dizziness, and fatigue. Electrocardiogram typically shows sinus bradycardia, sinus arrest, and/or sinoatrial block. Episodes of atrial tachycardias coexisting with sinus bradycardia ('tachycardia-bradycardia syndrome') are also common in this disorder. SSS occurs most often in the elderly associated with underlying heart disease or previous cardiac surgery, but can also occur in the fetus, infant, or child without heart disease or other contributing factors, in which case it is considered to be a congenital disorder (Benson et al., 2003). Genetic Heterogeneity of Sick Sinus Syndrome Sick sinus syndrome-2 (SSS2; 163800) is caused by mutation in the HCN4 gene (605206). Susceptibility to sick sinus syndrome-3 (SSS3; 614090) is influenced by variation in the MYH6 gene (160710). Sick sinus syndrome-4 (SSS4; 619464) is caused by mutation in the GNB2 gene (139390).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/325270">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_333884"><div><strong>Progressive familial heart block type II</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>333884</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1841658</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Progressive familial heart block type II (PFHB2) is an autosomal dominant disorder, similar to type I progressive familial heart block (PFHB1; see 113900). The pattern of PFHB2, however, tends to develop along the lines of a sinus bradycardia with a left posterior hemiblock, presenting clinically as syncopal episodes, Stokes-Adams seizures, or sudden death when complete heart block supervenes (Brink and Torrington, 1977).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/333884">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_347714"><div><strong>Dilated cardiomyopathy 1G</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>347714</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1858763</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Dilated cardiomyopathy-1G (CMD1G) is an autosomal dominant disorder characterized by ventricular dilatation and systolic contractile dysfunction (Siu et al., 1999). For a general phenotypic description and a discussion of genetic heterogeneity of dilated cardiomyopathy (CMD), see CMD1A (115200).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/347714">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_350526"><div><strong>Hypertrophic cardiomyopathy 4</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>350526</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1861862</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">While most people with familial hypertrophic cardiomyopathy are symptom-free or have only mild symptoms, this condition can have serious consequences. It can cause abnormal heart rhythms (arrhythmias) that may be life threatening. People with familial hypertrophic cardiomyopathy have an increased risk of sudden death, even if they have no other symptoms of the condition. A small number of affected individuals develop potentially fatal heart failure, which may require heart transplantation.\n\nNonfamilial hypertrophic cardiomyopathy tends to be milder. This form typically begins later in life than familial hypertrophic cardiomyopathy, and affected individuals have a lower risk of serious cardiac events and sudden death than people with the familial form.\n\nThe symptoms of familial hypertrophic cardiomyopathy are variable, even within the same family. Many affected individuals have no symptoms. Other people with familial hypertrophic cardiomyopathy may experience chest pain; shortness of breath, especially with physical exertion; a sensation of fluttering or pounding in the chest (palpitations); lightheadedness; dizziness; and fainting.\n\nIn familial hypertrophic cardiomyopathy, cardiac thickening usually occurs in the interventricular septum, which is the muscular wall that separates the lower left chamber of the heart (the left ventricle) from the lower right chamber (the right ventricle). In some people, thickening of the interventricular septum impedes the flow of oxygen-rich blood from the heart, which may lead to an abnormal heart sound during a heartbeat (heart murmur) and other signs and symptoms of the condition. Other affected individuals do not have physical obstruction of blood flow, but the pumping of blood is less efficient, which can also lead to symptoms of the condition. Familial hypertrophic cardiomyopathy often begins in adolescence or young adulthood, although it can develop at any time throughout life.\n\nHypertrophic cardiomyopathy is a heart condition characterized by thickening (hypertrophy) of the heart (cardiac) muscle. When multiple members of a family have the condition, it is known as familial hypertrophic cardiomyopathy. Hypertrophic cardiomyopathy also occurs in people with no family history; these cases are considered nonfamilial hypertrophic cardiomyopathy. </div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/350526">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_370220"><div><strong>Progressive familial heart block type IB</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>370220</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1970298</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Progressive familial heart block can be divided into type I and type II, with type I being further divided into types IA and IB. These types differ in where in the heart signaling is interrupted and the genetic cause. In types IA and IB, the heart block originates in the bundle branch, and in type II, the heart block originates in the atrioventricular node. The different types of progressive familial heart block have similar signs and symptoms.\n\nHeart block occurs when the electrical signaling is obstructed anywhere from the atria to the ventricles. In people with progressive familial heart block, the condition worsens over time: early in the disorder, the electrical signals are partially blocked, but the block eventually becomes complete, preventing any signals from passing through the heart. Partial heart block causes a slow or irregular heartbeat (bradycardia or arrhythmia, respectively), and can lead to the buildup of scar tissue (fibrosis) in the cells that carry electrical impulses. Fibrosis contributes to the development of complete heart block, resulting in uncoordinated electrical signaling between the atria and the ventricles and inefficient pumping of blood in the heart. Complete heart block can cause a sensation of fluttering or pounding in the chest (palpitations), shortness of breath, fainting (syncope), or sudden cardiac arrest and death.\n\nMost cases of heart block are not genetic and are not considered progressive familial heart block. The most common cause of heart block is fibrosis of the heart, which occurs as a normal process of aging. Other causes of heart block can include the use of certain medications or an infection of the heart tissue.\n\nProgressive familial heart block is a genetic condition that alters the normal beating of the heart. A normal heartbeat is controlled by electrical signals that move through the heart in a highly coordinated way. These signals begin in a specialized cluster of cells called the sinoatrial node (the heart's natural pacemaker) located in the heart's upper chambers (the atria). From there, a group of cells called the atrioventricular node carries the electrical signals to another cluster of cells called the bundle of His. This bundle separates into multiple thin spindles called bundle branches, which carry electrical signals into the heart's lower chambers (the ventricles). Electrical impulses move from the sinoatrial node down to the bundle branches, stimulating a normal heartbeat in which the ventricles contract slightly later than the atria.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/370220">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_435983"><div><strong>Early-onset myopathy with fatal cardiomyopathy</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>435983</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C2673677</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Salih myopathy is characterized by muscle weakness (manifest during the neonatal period or in early infancy) and delayed motor development; children acquire independent walking between ages 20 months and four years. In the first decade of life, global motor performance is stable or tends to improve. Moderate joint and neck contractures and spinal rigidity may manifest in the first decade but become more obvious in the second decade. Scoliosis develops after age 11 years. Cardiac dysfunction manifests between ages five and 16 years, progresses rapidly, and leads to death between ages eight and 20 years, usually from heart rhythm disturbances.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/435983">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_393713"><div><strong>Dilated cardiomyopathy 1AA</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>393713</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C2677338</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Any familial isolated dilated cardiomyopathy in which the cause of the disease is a mutation in the ACTN2 gene.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/393713">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_394836"><div><strong>Long QT syndrome 10</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>394836</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C2678484</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Any long QT syndrome in which the cause of the disease is a mutation in the SCN4B gene.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/394836">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_462083"><div><strong>Long QT syndrome 13</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>462083</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C3150733</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Congenital long QT syndrome is electrocardiographically characterized by a prolonged QT interval and polymorphic ventricular arrhythmias (torsade de pointes). These cardiac arrhythmias may result in recurrent syncope, seizure, or sudden death (Jongbloed et al., 1999). For a discussion of genetic heterogeneity of long QT syndrome, see LQT1 (192500).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/462083">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_482322"><div><strong>Microcephaly-cerebellar hypoplasia-cardiac conduction defect syndrome</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>482322</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C3280692</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">The Zaki-Gleeson syndrome is an autosomal recessive neurodevelopmental disorder characterized by profound mental retardation, severe microcephaly, poor growth, cerebellar hypoplasia, and second-degree cardiac conduction defects (Zaki et al., 2011).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/482322">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_767108"><div><strong>Congenital heart defects, multiple types, 3</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>767108</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C3554194</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Multiple types of congenital heart defects-3 (CHTD3) is an autosomal dominant condition characterized by various types of congenital heart defects and low atrial rhythm (van de Meerakker et al., 2011). For a general phenotypic description and a discussion of genetic heterogeneity of multiple types of congenital heart defects, see 306955.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/767108">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_934716"><div><strong>Hypertrophic cardiomyopathy 26</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>934716</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C4310749</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Familial cardiomyopathy caused by mutation in the FLNC gene has been described as hypertrophic, restrictive, dilated, or arrhythmogenic right ventricular cardiomyopathy. Affected individuals, especially those with dilated cardiomyopathy, are at risk for arrhythmias and sudden death. Arrhythmias without cardiomyopathy, and left ventricular noncompaction, have also been reported (Ortiz-Genga et al., 2016; Verdonschot et al., 2020).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/934716">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_1720295"><div><strong>Emery-Dreifuss muscular dystrophy 1, X-linked</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1720295</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C5243475</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Emery-Dreifuss muscular dystrophy (EDMD) is characterized by the clinical triad of: joint contractures that begin in early childhood; slowly progressive muscle weakness and wasting initially in a humero-peroneal distribution that later extends to the scapular and pelvic girdle muscles; and cardiac involvement that may manifest as palpitations, presyncope and syncope, poor exercise tolerance, and congestive heart failure along with variable cardiac rhythm disturbances. Age of onset, severity, and progression of muscle and cardiac involvement demonstrate both inter- and intrafamilial variability. Clinical variability ranges from early onset with severe presentation in childhood to late onset with slow progression in adulthood. In general, joint contractures appear during the first two decades, followed by muscle weakness and wasting. Cardiac involvement usually occurs after the second decade and respiratory function may be impaired in some individuals.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1720295">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_1794159"><div><strong>Sick sinus syndrome 4</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1794159</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C5561949</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Sick sinus syndrome-4 (SSS4) is characterized by early and progressive sinus node and atrioventricular conduction dysfunction. Patients show bradycardia and chronotropic incompetence, and may experience syncope. Atrioventricular conduction block ranges from mild to severe, and some patients also have intermittent atrial fibrillation. Many require implantation of a pacemaker, but sudden cardiac death has not been reported (Stallmeyer et al., 2017). For a general phenotypic description and discussion of genetic heterogeneity of sick sinus syndrome, see SSS1 (608567).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1794159">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_1863339"><div><strong>Pulmonary hypertension, primary, 6</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1863339</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C5935600</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Primary pulmonary hypertension-6 (PPH6) is characterized by markedly elevated pulmonary arterial hypertension, associated with reduced oxygen saturation and diffuse ground-glass opacities on chest x-ray. Lung biopsy shows thickening of the alveolar septae and abnormally proliferating capillaries (Postma et al., 2023). For a general phenotypic description and a discussion of genetic heterogeneity of primary pulmonary hypertension, see PPH1 (178600).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1863339">Condition Record</a></div></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_91000" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Carnitine acylcarnitine translocase deficiency</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_351513" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Catecholaminergic polymorphic ventricular tachycardia 1</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_57432" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Congenital heart block</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_767108" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Congenital heart defects, multiple types, 3</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_209235" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Danon disease</a></div><div class="jig-moreless" data-jigconfig="class: 'moveDown', moreText: 'See full list (24)', lessText: 'Show less', nodeBefore: 0"><span id="clinMore">
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_393713" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Dilated cardiomyopathy 1AA</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_331341" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Dilated cardiomyopathy 1E</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_347714" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Dilated cardiomyopathy 1G</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_435983" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Early-onset myopathy with fatal cardiomyopathy</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1720295" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Emery-Dreifuss muscular dystrophy 1, X-linked</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_354526" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Familial partial lipodystrophy, Dunnigan type</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_934716" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Hypertrophic cardiomyopathy 26</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_350526" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Hypertrophic cardiomyopathy 4</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_331466" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Hypertrophic cardiomyopathy 6</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_394836" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Long QT syndrome 10</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_462083" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Long QT syndrome 13</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_482322" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Microcephaly-cerebellar hypoplasia-cardiac conduction defect syndrome</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_75658" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Primary hyperoxaluria, type I</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_370220" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Progressive familial heart block type IB</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_333884" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Progressive familial heart block type II</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1863339" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Pulmonary hypertension, primary, 6</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_325270" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Sick sinus syndrome 1</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1794159" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Sick sinus syndrome 4</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_331395" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Timothy syndrome</a></div></span></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_105">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Professional_guidelines">Professional guidelines</h1><a sid="105" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">PubMed<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpPM"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/30412709">2018 ACC/AHA/HRS Guideline on the Evaluation and Management of Patients With Bradycardia and Cardiac Conduction Delay: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines and the Heart Rhythm Society.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Kusumoto FM,
|
||
Schoenfeld MH,
|
||
Barrett C,
|
||
Edgerton JR,
|
||
Ellenbogen KA,
|
||
Gold MR,
|
||
Goldschlager NF,
|
||
Hamilton RM,
|
||
Joglar JA,
|
||
Kim RJ,
|
||
Lee R,
|
||
Marine JE,
|
||
McLeod CJ,
|
||
Oken KR,
|
||
Patton KK,
|
||
Pellegrini CN,
|
||
Selzman KA,
|
||
Thompson A,
|
||
Varosy PD</span><br />
|
||
<span class="medgenPMjournal">J Am Coll Cardiol</span>
|
||
2019 Aug 20;74(7):e51-e156.
|
||
Epub 2018 Nov 6
|
||
doi: 10.1016/j.jacc.2018.10.044.
|
||
<span class="bold">PMID: </span><a href="/pubmed/30412709" target="_blank">30412709</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/27484658">Bradyarrhythmias: Clinical Presentation, Diagnosis, and Management.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Wung SF</span><br />
|
||
<span class="medgenPMjournal">Crit Care Nurs Clin North Am</span>
|
||
2016 Sep;28(3):297-308.
|
||
Epub 2016 Jun 22
|
||
doi: 10.1016/j.cnc.2016.04.003.
|
||
<span class="bold">PMID: </span><a href="/pubmed/27484658" target="_blank">27484658</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/26780751">Evaluation and management of bradycardia in neonates and children.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Baruteau AE,
|
||
Perry JC,
|
||
Sanatani S,
|
||
Horie M,
|
||
Dubin AM</span><br />
|
||
<span class="medgenPMjournal">Eur J Pediatr</span>
|
||
2016 Feb;175(2):151-61.
|
||
Epub 2016 Jan 16
|
||
doi: 10.1007/s00431-015-2689-z.
|
||
<span class="bold">PMID: </span><a href="/pubmed/26780751" target="_blank">26780751</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(%22atrioventricular%20block%22%5Btiab%3A~0%5D)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">See all (200)</a></div></div>
|
||
</div>
|
||
<div class="display-none help-popup" id="guidelinesHelpPM">These guidelines are articles in PubMed that match specific search criteria developed by MedGen to capture the most relevant practice guidelines. This list may not be comprehensive and may include broader topics as well. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div><div class="display-none help-popup" id="guidelinesHelpCurated">These guidelines are manually curated by the MedGen team
|
||
to supplement articles available in PubMed. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div>
|
||
<div class="portlet mgSection" id="ID_103">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_clinical_studies">Recent clinical studies</h1><a sid="103" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">Etiology</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/33167002">Abdominal pain and atrioventricular block: beyond pacemaker implantation.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Irigaray Sierra P,
|
||
Gayán Ordás J,
|
||
Pastor Pueyo P,
|
||
Viles Bertrán D</span><br />
|
||
<span class="medgenPMjournal">Eur Heart J</span>
|
||
2021 Jul 31;42(29):2867.
|
||
doi: 10.1093/eurheartj/ehaa805.
|
||
<span class="bold">PMID: </span><a href="/pubmed/33167002" target="_blank">33167002</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/30738635">Fetal dysrhythmias.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Carvalho JS</span><br />
|
||
<span class="medgenPMjournal">Best Pract Res Clin Obstet Gynaecol</span>
|
||
2019 Jul;58:28-41.
|
||
Epub 2019 Jan 9
|
||
doi: 10.1016/j.bpobgyn.2019.01.002.
|
||
<span class="bold">PMID: </span><a href="/pubmed/30738635" target="_blank">30738635</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/30172280">Pacing-Induced Cardiomyopathy.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Merchant FM,
|
||
Mittal S</span><br />
|
||
<span class="medgenPMjournal">Card Electrophysiol Clin</span>
|
||
2018 Sep;10(3):437-445.
|
||
Epub 2018 Jul 20
|
||
doi: 10.1016/j.ccep.2018.05.005.
|
||
<span class="bold">PMID: </span><a href="/pubmed/30172280" target="_blank">30172280</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/27484658">Bradyarrhythmias: Clinical Presentation, Diagnosis, and Management.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Wung SF</span><br />
|
||
<span class="medgenPMjournal">Crit Care Nurs Clin North Am</span>
|
||
2016 Sep;28(3):297-308.
|
||
Epub 2016 Jun 22
|
||
doi: 10.1016/j.cnc.2016.04.003.
|
||
<span class="bold">PMID: </span><a href="/pubmed/27484658" target="_blank">27484658</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/22897386">A review on advanced atrioventricular block in young or middle-aged adults.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Barra SN,
|
||
Providência R,
|
||
Paiva L,
|
||
Nascimento J,
|
||
Marques AL</span><br />
|
||
<span class="medgenPMjournal">Pacing Clin Electrophysiol</span>
|
||
2012 Nov;35(11):1395-405.
|
||
Epub 2012 Aug 16
|
||
doi: 10.1111/j.1540-8159.2012.03489.x.
|
||
<span class="bold">PMID: </span><a href="/pubmed/22897386" target="_blank">22897386</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Atrioventricular%20block%22%20AND%20Etiology%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (3193)</a></div><h3 class="subhead">Diagnosis</h3>
|
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<div class="nl"><a target="_blank" href="/pubmed/34689889">Electrocardiography of Atrioventricular Block.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Clark BA,
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Prystowsky EN</span><br />
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<span class="medgenPMjournal">Card Electrophysiol Clin</span>
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2021 Dec;13(4):599-605.
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Epub 2021 Sep 25
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doi: 10.1016/j.ccep.2021.07.001.
|
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<span class="bold">PMID: </span><a href="/pubmed/34689889" target="_blank">34689889</a></div>
|
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|
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<div class="nl"><a target="_blank" href="/pubmed/34125143">Paroxysmal Atrioventricular Block.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Hyman MC,
|
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Papireddy M,
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Frankel DS</span><br />
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<span class="bold">PMID: </span><a href="/pubmed/34125143" target="_blank">34125143</a></div>
|
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<div class="nl"><a target="_blank" href="/pubmed/33087679">Exercise-induced Atrioventricular Block.</a></div>
|
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<div class="portlet_content ln"><span class="medgenPMauthor">Aizawa Y,
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Kawamura A</span><br />
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<span class="medgenPMjournal">Intern Med</span>
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2021 Mar 15;60(6):827-828.
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Epub 2020 Oct 21
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<span class="bold">PMID: </span><a href="/pubmed/33087679" target="_blank">33087679</a><a href="/pmc/articles/PMC8024956" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
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|
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<div class="nl"><a target="_blank" href="/pubmed/27484658">Bradyarrhythmias: Clinical Presentation, Diagnosis, and Management.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Wung SF</span><br />
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<span class="medgenPMjournal">Crit Care Nurs Clin North Am</span>
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2016 Sep;28(3):297-308.
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<span class="bold">PMID: </span><a href="/pubmed/27484658" target="_blank">27484658</a></div>
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<div class="nl"><a target="_blank" href="/pubmed/23286970">Vagally mediated atrioventricular block: pathophysiology and diagnosis.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Alboni P,
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Holz A,
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Brignole M</span><br />
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<span class="medgenPMjournal">Heart</span>
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2013 Jul;99(13):904-8.
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Epub 2013 Jan 2
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<span class="bold">PMID: </span><a href="/pubmed/23286970" target="_blank">23286970</a></div>
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<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Atrioventricular%20block%22%20AND%20Diagnosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (3225)</a></div><h3 class="subhead">Therapy</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/39831954">Blood Pressure Control and Incident Left-Ventricular Conduction Disease.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Frimodt-Møller EK,
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Marcus GM</span><br />
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<span class="medgenPMjournal">Curr Cardiol Rep</span>
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2025 Jan 20;27(1):29.
|
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doi: 10.1007/s11886-025-02196-w.
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<span class="bold">PMID: </span><a href="/pubmed/39831954" target="_blank">39831954</a></div>
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<div class="nl"><a target="_blank" href="/pubmed/37321691">Reversible Causes of Atrioventricular Block.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Pavone C,
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Pelargonio G</span><br />
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<span class="medgenPMjournal">Cardiol Clin</span>
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2023 Aug;41(3):411-418.
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doi: 10.1016/j.ccl.2023.03.004.
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<span class="bold">PMID: </span><a href="/pubmed/37321691" target="_blank">37321691</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/35362165">Cardioneuroablation for vasovagal syncope and atrioventricular block: A step-by-step guide.</a></div>
|
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<div class="portlet_content ln"><span class="medgenPMauthor">Aksu T,
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Gupta D,
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D'Avila A,
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Morillo CA</span><br />
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<span class="medgenPMjournal">J Cardiovasc Electrophysiol</span>
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2022 Oct;33(10):2205-2212.
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Epub 2022 Apr 9
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doi: 10.1111/jce.15480.
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<span class="bold">PMID: </span><a href="/pubmed/35362165" target="_blank">35362165</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/29789287">Lyme carditis and atrioventricular block.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Wan D,
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Baranchuk A</span><br />
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<span class="medgenPMjournal">CMAJ</span>
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2018 May 22;190(20):E622.
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doi: 10.1503/cmaj.171452.
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<span class="bold">PMID: </span><a href="/pubmed/29789287" target="_blank">29789287</a><a href="/pmc/articles/PMC5962393" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/29335320">January 15th Question.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Noheria A</span><br />
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<span class="medgenPMjournal">Circ Arrhythm Electrophysiol</span>
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2018 Jan;11(1):e006125.
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doi: 10.1161/CIRCEP.117.006125.
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<span class="bold">PMID: </span><a href="/pubmed/29335320" target="_blank">29335320</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Atrioventricular%20block%22%20AND%20Therapy%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (2603)</a></div><h3 class="subhead">Prognosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/39831954">Blood Pressure Control and Incident Left-Ventricular Conduction Disease.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Frimodt-Møller EK,
|
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Marcus GM</span><br />
|
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<span class="medgenPMjournal">Curr Cardiol Rep</span>
|
||
2025 Jan 20;27(1):29.
|
||
doi: 10.1007/s11886-025-02196-w.
|
||
<span class="bold">PMID: </span><a href="/pubmed/39831954" target="_blank">39831954</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/34465122">Cardioneuroablation for Treatment of Atrioventricular Block.</a></div>
|
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<div class="portlet_content ln"><span class="medgenPMauthor">Aksu T,
|
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Gopinathannair R,
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Bozyel S,
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Yalin K,
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Gupta D</span><br />
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<span class="medgenPMjournal">Circ Arrhythm Electrophysiol</span>
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2021 Sep;14(9):e010018.
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Epub 2021 Sep 1
|
||
doi: 10.1161/CIRCEP.121.010018.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34465122" target="_blank">34465122</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/33478630">Incidence, Predictors, and Implications of Permanent Pacemaker Requirement After Transcatheter Aortic Valve Replacement.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Sammour Y,
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Krishnaswamy A,
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Kumar A,
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Puri R,
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Tarakji KG,
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Bazarbashi N,
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Harb S,
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Griffin B,
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Svensson L,
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Wazni O,
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Kapadia SR</span><br />
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<span class="medgenPMjournal">JACC Cardiovasc Interv</span>
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2021 Jan 25;14(2):115-134.
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doi: 10.1016/j.jcin.2020.09.063.
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<span class="bold">PMID: </span><a href="/pubmed/33478630" target="_blank">33478630</a></div>
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<div class="nl"><a target="_blank" href="/pubmed/30105429">His bundle pacing.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Payne J,
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Garlitski AC,
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Weinstock J,
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Homoud M,
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Madias C,
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Estes NAM</span><br />
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<span class="medgenPMjournal">J Interv Card Electrophysiol</span>
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2018 Aug;52(3):323-334.
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Epub 2018 Aug 13
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<span class="bold">PMID: </span><a href="/pubmed/30105429" target="_blank">30105429</a></div>
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<div class="nl"><a target="_blank" href="/pubmed/29411428">Pacemaker therapy in low-birth-weight infants.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Fuchigami T,
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Nishioka M,
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Akashige T,
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Shimabukuro A,
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Nagata N</span><br />
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<span class="bold">PMID: </span><a href="/pubmed/29411428" target="_blank">29411428</a></div>
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<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Atrioventricular%20block%22%20AND%20Prognosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (2182)</a></div><h3 class="subhead">Clinical prediction guides</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/37321692">Iatrogenic Atrioventricular Block.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Cheung CC,
|
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Mori S,
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Gerstenfeld EP</span><br />
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<span class="medgenPMjournal">Cardiol Clin</span>
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2023 Aug;41(3):419-428.
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doi: 10.1016/j.ccl.2023.03.009.
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<span class="bold">PMID: </span><a href="/pubmed/37321692" target="_blank">37321692</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/34689898">Iatrogenic Atrioventricular Block.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Cheung CC,
|
||
Mori S,
|
||
Gerstenfeld EP</span><br />
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<span class="medgenPMjournal">Card Electrophysiol Clin</span>
|
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2021 Dec;13(4):711-720.
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||
Epub 2021 Sep 25
|
||
doi: 10.1016/j.ccep.2021.06.010.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34689898" target="_blank">34689898</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/31311698">Evaluating and managing bradycardia.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Sidhu S,
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Marine JE</span><br />
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<span class="medgenPMjournal">Trends Cardiovasc Med</span>
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2020 Jul;30(5):265-272.
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Epub 2019 Jul 9
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doi: 10.1016/j.tcm.2019.07.001.
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<span class="bold">PMID: </span><a href="/pubmed/31311698" target="_blank">31311698</a></div>
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<div class="nl"><a target="_blank" href="/pubmed/31180745">Prolonged Ventricular Asystole.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Prasada S,
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Nishtala A,
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Goldschlager N</span><br />
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<span class="medgenPMjournal">Circulation</span>
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2019 Jun 11;139(24):2798-2801.
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Epub 2019 Jun 10
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doi: 10.1161/CIRCULATIONAHA.119.041051.
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<span class="bold">PMID: </span><a href="/pubmed/31180745" target="_blank">31180745</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/23286970">Vagally mediated atrioventricular block: pathophysiology and diagnosis.</a></div>
|
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<div class="portlet_content ln"><span class="medgenPMauthor">Alboni P,
|
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Holz A,
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Brignole M</span><br />
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<span class="medgenPMjournal">Heart</span>
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2013 Jul;99(13):904-8.
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Epub 2013 Jan 2
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doi: 10.1136/heartjnl-2012-303220.
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<span class="bold">PMID: </span><a href="/pubmed/23286970" target="_blank">23286970</a></div>
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<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Atrioventricular%20block%22%20AND%20Clinical%20prediction%20guides%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (1882)</a></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_104">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_systematic_reviews">Recent systematic reviews</h1><a sid="104" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln">
|
||
<div class="nl"><a target="_blank" href="/pubmed/38902995">A systematic review of the clinical characteristics and course of atrioventricular blocks in hyperthyroidism.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Ata F,
|
||
Khan HA,
|
||
Choudry H,
|
||
Khan AA,
|
||
Tahir S,
|
||
Cerqueira TL,
|
||
Illigens B</span><br />
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<span class="medgenPMjournal">Ann Med</span>
|
||
2024 Dec;56(1):2365405.
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||
Epub 2024 Jun 21
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||
doi: 10.1080/07853890.2024.2365405.
|
||
<span class="bold">PMID: </span><a href="/pubmed/38902995" target="_blank">38902995</a><a href="/pmc/articles/PMC11195459" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/34831876">Knowledge Update on the Economic Evaluation of Pacemaker Telemonitoring Systems.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Lopez-Villegas A,
|
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Leal-Costa C,
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||
Perez-Heredia M,
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Villegas-Tripiana I,
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Catalán-Matamoros D</span><br />
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<span class="medgenPMjournal">Int J Environ Res Public Health</span>
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2021 Nov 18;18(22)
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doi: 10.3390/ijerph182212120.
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||
<span class="bold">PMID: </span><a href="/pubmed/34831876" target="_blank">34831876</a><a href="/pmc/articles/PMC8624333" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/32205299">Cardiac radioablation-A systematic review.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">van der Ree MH,
|
||
Blanck O,
|
||
Limpens J,
|
||
Lee CH,
|
||
Balgobind BV,
|
||
Dieleman EMT,
|
||
Wilde AAM,
|
||
Zei PC,
|
||
de Groot JR,
|
||
Slotman BJ,
|
||
Cuculich PS,
|
||
Robinson CG,
|
||
Postema PG</span><br />
|
||
<span class="medgenPMjournal">Heart Rhythm</span>
|
||
2020 Aug;17(8):1381-1392.
|
||
Epub 2020 Mar 20
|
||
doi: 10.1016/j.hrthm.2020.03.013.
|
||
<span class="bold">PMID: </span><a href="/pubmed/32205299" target="_blank">32205299</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/31983240">An International, Multicentered, Evidence-Based Reappraisal of Genes Reported to Cause Congenital Long QT Syndrome.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Adler A,
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||
Novelli V,
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Amin AS,
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Abiusi E,
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Care M,
|
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Nannenberg EA,
|
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Feilotter H,
|
||
Amenta S,
|
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Mazza D,
|
||
Bikker H,
|
||
Sturm AC,
|
||
Garcia J,
|
||
Ackerman MJ,
|
||
Hershberger RE,
|
||
Perez MV,
|
||
Zareba W,
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Ware JS,
|
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Wilde AAM,
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Gollob MH</span><br />
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<span class="medgenPMjournal">Circulation</span>
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||
2020 Feb 11;141(6):418-428.
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Epub 2020 Jan 27
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doi: 10.1161/CIRCULATIONAHA.119.043132.
|
||
<span class="bold">PMID: </span><a href="/pubmed/31983240" target="_blank">31983240</a><a href="/pmc/articles/PMC7017940" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/25540845">Systematic review of cardiac electrical disease in Kearns-Sayre syndrome and mitochondrial cytopathy.</a></div>
|
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<div class="portlet_content ln"><span class="medgenPMauthor">Kabunga P,
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Lau AK,
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Phan K,
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Puranik R,
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Liang C,
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Davis RL,
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Sue CM,
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<span class="medgenPMjournal">Int J Cardiol</span>
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2015 Feb 15;181:303-10.
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Epub 2014 Dec 13
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<span class="bold">PMID: </span><a href="/pubmed/25540845" target="_blank">25540845</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Atrioventricular%20block%22%20AND%20systematic%5Bsb%5D%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (80)</a></div></div>
|
||
</div>
|
||
</div></div></div></div></div></div></div>
|
||
<div id="messagearea_bottom">
|
||
|
||
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|
||
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|
||
|
||
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|
||
|
||
</div>
|
||
</div>
|
||
<div class="supplemental col three_col last">
|
||
<h2 class="offscreen_noflow">Supplemental Content</h2>
|
||
|
||
<div>
|
||
|
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<div class="portlet mgSection" id="ID_113">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Table_of_contents">Table of contents</h1><a sid="113" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="portlet mgSection" id="ID_106">
|
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Genetic_Testing_Registry">Genetic Testing Registry</h1><a sid="106" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><ul><li><a href="/gtr/tests?term=C0004245%5bDISCUI%5d&filter=method%3A2%5F8" target="_blank">Deletion/duplication analysis (5)</a></li>
|
||
<li><a href="/gtr/tests?term=C0004245%5bDISCUI%5d&filter=method%3A2%5F17" target="_blank">Mutation scanning of the entire coding region (1)</a></li>
|
||
<li><a href="/gtr/tests?term=C0004245%5bDISCUI%5d&filter=method%3A2%5F7" target="_blank">Sequence analysis of the entire coding region (7)</a></li>
|
||
<li><a href="/gtr/tests?term=C0004245%5bDISCUI%5d&filter=method%3A2%5F19" target="_blank">Targeted variant analysis (4)</a></li>
|
||
<li class="portletSeeAll portletSeeAllPad"><total><a href="/gtr/tests?term=C0004245%5bDISCUI%5d" target="_blank">See all (8)</a></total></li>
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