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<meta name="keywords" content="C0002768, analgesia, congenital, asymbolia, channelopathy-associated insensitivity to pain, congenital analgesia, congenital indifference to pain, congenital insensitivity to pain, congenital pain asymbolia, congenital pain indifference, congenital pain indifferences, congenital pain insensitivity, disease or syndrome, insensitivity to pain, congenital, insensitivity, congenital pain, pain indifference, congenital, pain insensitivity, congenital, autosomal dominant, autosomal recessive, birth defects, chromosomal disease, chromosome, clinical features, clinical findings, clinical genetics, clinical recommendations, clinvar, congenital chromosomal disease, consumer genetic resources, cytogenetic location, disease characteristics, disease definitions, disease descriptions, disease ontology, disease synonyms, disease vocabulary, dysmorphology, entrez, familial disease, gene, gene-disease relationship, genereviews, genetic disease, genetic disorder, genetic terminology, genetic testing registry, genetics home reference, genomic disease, gtr, hereditary disease, heritable disease, hpo, human phenotype ontology, inherited disease, management guidelines, maternal inheritance, medgen, medical genetics, medical subject headings, mesh, mitochondrial inheritance, mode of inheritance, national center for biotechnology information, national institutes of health, national library of medicine, ncbi, nih, nlm, omim, ordo, orphanet, paternal inheritance, phenome, position statements, professional practice guidelines, rare disease, reference sequence, refseq, snomed ct, syndrome, undiagnosed diseases, x-linked recessive" /><meta name="description" content="A syndrome characterized by indifference to PAIN despite the ability to distinguish noxious from non-noxious stimuli. Absent corneal reflexes and INTELLECTUAL DISABILITY may be associated. Familial forms with autosomal recessive and autosomal dominant patterns of inheritance have been described. (Adams et al., Principles of Neurology, 6th ed, p1343)" /><meta name="robots" content="index,nofollow,noarchive" />
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||
<!--
|
||
UID=1899
|
||
ConceptID=C0002768
|
||
-->
|
||
<!--imgCountBooks = 0--><h1 class="medgenTitle"><div class="MedGenTitleText">Congenital Indifference to Pain</div></h1><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1899</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information."><span class="highlight" style="background-color:">C0002768</span></a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div><table class="medgenTable"><tbody><tr><td>Synonyms:</td>
|
||
<td>Analgesia, Congenital; Channelopathy-Associated Insensitivity To Pain; Congenital Analgesia; Congenital Insensitivity To Pain; Congenital Pain Indifference; Congenital Pain Indifferences; Congenital Pain Insensitivity; Insensitivity To Pain, Congenital; Insensitivity, Congenital Pain; Pain Indifference, Congenital; Pain Insensitivity, Congenital</td></tr>
|
||
<tr><td><span class="bold">SNOMED CT: </span></td>
|
||
<td>Congenital indifference to pain (403605007); Congenital pain asymbolia (403605007); Asymbolia (403605007)</td></tr>
|
||
</tbody></table></div><div class="rprt-body jig-ncbiinpagenav" data-jigconfig="smoothScroll: false, gotoTopLink: true, gotoTopLinkText: '', gotoTopLinkAttrs: {'title': 'Go to the top of the page'},allHeadingLevels: ['h1'], topOfPageTOC: true, tocId: 'my-toc'"><div id="rprt-tabs-1" class="rprt-tab"><div id="tb-termsProp-1"><div class="leftCol mgCol"><div>
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<div class="portlet mgSection" id="ID_100">
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||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Definition">Definition</h1><a sid="100" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln">A syndrome characterized by indifference to PAIN despite the ability to distinguish noxious from non-noxious stimuli. Absent corneal reflexes and INTELLECTUAL DISABILITY may be associated. Familial forms with autosomal recessive and autosomal dominant patterns of inheritance have been described. (Adams et al., Principles of Neurology, 6th ed, p1343) [from <a title="Medical Subject Headings" href="http://www.nlm.nih.gov/pubs/factsheets/mesh.html" class="defSource" target="_blank">MeSH</a>]</div>
|
||
</div>
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||
|
||
<div class="portlet mgSection" id="ID_118">
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||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Term_Hierarchy">Term Hierarchy</h1><a sid="118" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln HierarchyGTR"><div class="jig-ncbitabs"><ul><li><a href="#tabGTR">GTR</a></li><li><a href="#tabMGEN">MeSH</a></li></ul><div id="tabGTR"><div class="search_result"><div class="rprts"><div class="chiclet_legend"><span class="chiclet_list" style="position:static;"><span title="Clinical test" class="chiclet Ccolor round">C</span><span>Clinical test, </span><span title="Research test" class="chiclet Rcolor round">R</span><span>Research test, </span><span title="OMIM" class="chiclet Ocolor ">O</span><span>OMIM, </span><span title="GeneReview" class="chiclet Gcolor">G</span><span><em>GeneReviews</em>, </span><span title="ClinVar" class="chiclet Vcolor">V</span><span>ClinVar </span></span></div><div id="hierarchy" class="margin_t1"><div class="ds_tree"><ul><li class="matched_ds"><span class="TLline">Congenital Indifference to Pain</span></li></ul></div></div></div></div></div><div id="tabMGEN"><div class="ds_tree"><ul><li><span class="TLline"><a href="/medgen/14319" ref="tree=MeSH" title="MedGen record for Congenital, Hereditary, and Neonatal Diseases and Abnormalities">Congenital, Hereditary, and Neonatal Diseases and Abnormalities</a></span><ul><li><span class="TLline"><a href="/medgen/181981" ref="tree=MeSH" title="MedGen record for Inborn genetic diseases">Inborn genetic diseases</a></span><ul><li><span class="matched_ds">Congenital Indifference to Pain</span></li></ul></li></ul></li></ul></div></div></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_105">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Professional_guidelines">Professional guidelines</h1><a sid="105" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">PubMed<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpPM"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/26975306">Clinical features for diagnosis and management of patients with PRDM12 congenital insensitivity to pain.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Zhang S,
|
||
Malik Sharif S,
|
||
Chen YC,
|
||
Valente EM,
|
||
Ahmed M,
|
||
Sheridan E,
|
||
Bennett C,
|
||
Woods G</span><br />
|
||
<span class="medgenPMjournal">J Med Genet</span>
|
||
2016 Aug;53(8):533-5.
|
||
Epub 2016 Mar 14
|
||
doi: 10.1136/jmedgenet-2015-103646.
|
||
<span class="bold">PMID: </span><a href="/pubmed/26975306" target="_blank">26975306</a><a href="/pmc/articles/PMC4975812" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/23157347">Nerve growth factor-mediated regulation of pain signalling and proposed new intervention strategies in clinical pain management.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">McKelvey L,
|
||
Shorten GD,
|
||
O'Keeffe GW</span><br />
|
||
<span class="medgenPMjournal">J Neurochem</span>
|
||
2013 Feb;124(3):276-89.
|
||
doi: 10.1111/jnc.12093.
|
||
<span class="bold">PMID: </span><a href="/pubmed/23157347" target="_blank">23157347</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/21437824">Treatment of congenital malformations.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Brucker SY,
|
||
Rall K,
|
||
Campo R,
|
||
Oppelt P,
|
||
Isaacson K</span><br />
|
||
<span class="medgenPMjournal">Semin Reprod Med</span>
|
||
2011 Mar;29(2):101-12.
|
||
Epub 2011 Mar 24
|
||
doi: 10.1055/s-0031-1272472.
|
||
<span class="bold">PMID: </span><a href="/pubmed/21437824" target="_blank">21437824</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(congenital%20indifference%20to%20pain)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">See all (10)</a></div></div>
|
||
</div>
|
||
<div class="display-none help-popup" id="guidelinesHelpPM">These guidelines are articles in PubMed that match specific search criteria developed by MedGen to capture the most relevant practice guidelines. This list may not be comprehensive and may include broader topics as well. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div><div class="display-none help-popup" id="guidelinesHelpCurated">These guidelines are manually curated by the MedGen team
|
||
to supplement articles available in PubMed. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div>
|
||
<div class="portlet mgSection" id="ID_103">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_clinical_studies">Recent clinical studies</h1><a sid="103" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">Etiology</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/27637569">Orthopaedic manifestations of congenital indifference to pain with anhidrosis (Hereditary Sensory and Autonomic Neuropathy type IV).</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Kayani B,
|
||
Sewell MD,
|
||
Platinum J,
|
||
Olivier A,
|
||
Briggs TWR,
|
||
Eastwood DM</span><br />
|
||
<span class="medgenPMjournal">Eur J Paediatr Neurol</span>
|
||
2017 Mar;21(2):318-326.
|
||
Epub 2016 Sep 6
|
||
doi: 10.1016/j.ejpn.2016.08.009.
|
||
<span class="bold">PMID: </span><a href="/pubmed/27637569" target="_blank">27637569</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/23364568">A single-nucleotide polymorphism in SCN9A may decrease postoperative pain sensitivity in the general population.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Duan G,
|
||
Xiang G,
|
||
Zhang X,
|
||
Yuan R,
|
||
Zhan H,
|
||
Qi D</span><br />
|
||
<span class="medgenPMjournal">Anesthesiology</span>
|
||
2013 Feb;118(2):436-42.
|
||
doi: 10.1097/ALN.0b013e31827dde74.
|
||
<span class="bold">PMID: </span><a href="/pubmed/23364568" target="_blank">23364568</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/16566889">Congenital indifference to pain and deletion of chromosome 10q-: new association.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Joshi C,
|
||
Dawson AJ,
|
||
Sanders SR,
|
||
Prasad C</span><br />
|
||
<span class="medgenPMjournal">J Child Neurol</span>
|
||
2006 Feb;21(2):174-7.
|
||
doi: 10.1177/08830738060210022001.
|
||
<span class="bold">PMID: </span><a href="/pubmed/16566889" target="_blank">16566889</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/7543219">Congenital indifference to pain: long-term follow-up of two cases.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Hirsch E,
|
||
Moye D,
|
||
Dimon JH 3rd</span><br />
|
||
<span class="medgenPMjournal">South Med J</span>
|
||
1995 Aug;88(8):851-7.
|
||
doi: 10.1097/00007611-199508000-00014.
|
||
<span class="bold">PMID: </span><a href="/pubmed/7543219" target="_blank">7543219</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/92193">Congenital insensitivity to pain with anhydrosis. Report of a family and review of literature with reference to immune deficiency.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Vardy PA,
|
||
Greenberg LW,
|
||
Kachel C,
|
||
de Leon GF</span><br />
|
||
<span class="medgenPMjournal">Am J Dis Child</span>
|
||
1979 Nov;133(11):1153-5.
|
||
doi: 10.1001/archpedi.1979.02130110061011.
|
||
<span class="bold">PMID: </span><a href="/pubmed/92193" target="_blank">92193</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Congenital%20Indifference%20to%20Pain%22%20AND%20Etiology%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (5)</a></div><h3 class="subhead">Diagnosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/25426241">Congenital indifference to pain: an illustrated case report and literature review.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Golshani AE,
|
||
Kamdar AA,
|
||
Spence SC,
|
||
Beckmann NM</span><br />
|
||
<span class="medgenPMjournal">J Radiol Case Rep</span>
|
||
2014 Aug;8(8):16-23.
|
||
Epub 2014 Aug 31
|
||
doi: 10.3941/jrcr.v8i8.2194.
|
||
<span class="bold">PMID: </span><a href="/pubmed/25426241" target="_blank">25426241</a><a href="/pmc/articles/PMC4242143" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/10773933">Congenital indifference to pain.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Biswal N,
|
||
Sundaram VM,
|
||
Mathai B,
|
||
Balasubramanian S</span><br />
|
||
<span class="medgenPMjournal">Indian J Pediatr</span>
|
||
1998 Sep-Oct;65(5):755-7.
|
||
doi: 10.1007/BF02731060.
|
||
<span class="bold">PMID: </span><a href="/pubmed/10773933" target="_blank">10773933</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/1693303">Congenital indifference to pain mistaken for non-accidental injury.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Spencer JA,
|
||
Grieve DK</span><br />
|
||
<span class="medgenPMjournal">Br J Radiol</span>
|
||
1990 Apr;63(748):308-10.
|
||
doi: 10.1259/0007-1285-63-748-308.
|
||
<span class="bold">PMID: </span><a href="/pubmed/1693303" target="_blank">1693303</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/4175596">A case of congenital indifference to pain (neurologic and psychiatric findings).</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Kane J Jr,
|
||
Downie AW,
|
||
Marcotte DB,
|
||
Perez-Reyes M</span><br />
|
||
<span class="medgenPMjournal">Dis Nerv Syst</span>
|
||
1968 Jun;29(6):409-12.
|
||
<span class="bold">PMID: </span><a href="/pubmed/4175596" target="_blank">4175596</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/14253625">CONGENITAL INDIFFERENCE TO PAIN: ITS ORTHOPEDIC SIGNIFICANCE.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">MASON JL</span><br />
|
||
<span class="medgenPMjournal">J S C Med Assoc (Columbia)</span>
|
||
1965 Jan;61:5-9.
|
||
<span class="bold">PMID: </span><a href="/pubmed/14253625" target="_blank">14253625</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Congenital%20Indifference%20to%20Pain%22%20AND%20Diagnosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (19)</a></div><h3 class="subhead">Therapy</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/22845492">Human Mendelian pain disorders: a key to discovery and validation of novel analgesics.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Goldberg YP,
|
||
Pimstone SN,
|
||
Namdari R,
|
||
Price N,
|
||
Cohen C,
|
||
Sherrington RP,
|
||
Hayden MR</span><br />
|
||
<span class="medgenPMjournal">Clin Genet</span>
|
||
2012 Oct;82(4):367-73.
|
||
Epub 2012 Aug 13
|
||
doi: 10.1111/j.1399-0004.2012.01942.x.
|
||
<span class="bold">PMID: </span><a href="/pubmed/22845492" target="_blank">22845492</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/22035805">Treatment of Na(v)1.7-mediated pain in inherited erythromelalgia using a novel sodium channel blocker.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Goldberg YP,
|
||
Price N,
|
||
Namdari R,
|
||
Cohen CJ,
|
||
Lamers MH,
|
||
Winters C,
|
||
Price J,
|
||
Young CE,
|
||
Verschoof H,
|
||
Sherrington R,
|
||
Pimstone SN,
|
||
Hayden MR</span><br />
|
||
<span class="medgenPMjournal">Pain</span>
|
||
2012 Jan;153(1):80-85.
|
||
Epub 2011 Oct 28
|
||
doi: 10.1016/j.pain.2011.09.008.
|
||
<span class="bold">PMID: </span><a href="/pubmed/22035805" target="_blank">22035805</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/20529343">Effects of ranolazine on wild-type and mutant hNav1.7 channels and on DRG neuron excitability.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Estacion M,
|
||
Waxman SG,
|
||
Dib-Hajj SD</span><br />
|
||
<span class="medgenPMjournal">Mol Pain</span>
|
||
2010 Jun 8;6:35.
|
||
doi: 10.1186/1744-8069-6-35.
|
||
<span class="bold">PMID: </span><a href="/pubmed/20529343" target="_blank">20529343</a><a href="/pmc/articles/PMC2898769" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/17964852">Sodium channels and nociception: recent concepts and therapeutic opportunities.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Krafte DS,
|
||
Bannon AW</span><br />
|
||
<span class="medgenPMjournal">Curr Opin Pharmacol</span>
|
||
2008 Feb;8(1):50-6.
|
||
Epub 2007 Oct 26
|
||
doi: 10.1016/j.coph.2007.09.007.
|
||
<span class="bold">PMID: </span><a href="/pubmed/17964852" target="_blank">17964852</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/4105312">Congenital indifference to pain associated with a defect in calcium metabolism.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Haaxma R,
|
||
Korver MF,
|
||
Willemse J</span><br />
|
||
<span class="medgenPMjournal">Acta Neurol Scand</span>
|
||
1971;47(2):194-208.
|
||
doi: 10.1111/j.1600-0404.1971.tb07476.x.
|
||
<span class="bold">PMID: </span><a href="/pubmed/4105312" target="_blank">4105312</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Congenital%20Indifference%20to%20Pain%22%20AND%20Therapy%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (6)</a></div><h3 class="subhead">Prognosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/27637569">Orthopaedic manifestations of congenital indifference to pain with anhidrosis (Hereditary Sensory and Autonomic Neuropathy type IV).</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Kayani B,
|
||
Sewell MD,
|
||
Platinum J,
|
||
Olivier A,
|
||
Briggs TWR,
|
||
Eastwood DM</span><br />
|
||
<span class="medgenPMjournal">Eur J Paediatr Neurol</span>
|
||
2017 Mar;21(2):318-326.
|
||
Epub 2016 Sep 6
|
||
doi: 10.1016/j.ejpn.2016.08.009.
|
||
<span class="bold">PMID: </span><a href="/pubmed/27637569" target="_blank">27637569</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/25426241">Congenital indifference to pain: an illustrated case report and literature review.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Golshani AE,
|
||
Kamdar AA,
|
||
Spence SC,
|
||
Beckmann NM</span><br />
|
||
<span class="medgenPMjournal">J Radiol Case Rep</span>
|
||
2014 Aug;8(8):16-23.
|
||
Epub 2014 Aug 31
|
||
doi: 10.3941/jrcr.v8i8.2194.
|
||
<span class="bold">PMID: </span><a href="/pubmed/25426241" target="_blank">25426241</a><a href="/pmc/articles/PMC4242143" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/23364568">A single-nucleotide polymorphism in SCN9A may decrease postoperative pain sensitivity in the general population.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Duan G,
|
||
Xiang G,
|
||
Zhang X,
|
||
Yuan R,
|
||
Zhan H,
|
||
Qi D</span><br />
|
||
<span class="medgenPMjournal">Anesthesiology</span>
|
||
2013 Feb;118(2):436-42.
|
||
doi: 10.1097/ALN.0b013e31827dde74.
|
||
<span class="bold">PMID: </span><a href="/pubmed/23364568" target="_blank">23364568</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/16566889">Congenital indifference to pain and deletion of chromosome 10q-: new association.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Joshi C,
|
||
Dawson AJ,
|
||
Sanders SR,
|
||
Prasad C</span><br />
|
||
<span class="medgenPMjournal">J Child Neurol</span>
|
||
2006 Feb;21(2):174-7.
|
||
doi: 10.1177/08830738060210022001.
|
||
<span class="bold">PMID: </span><a href="/pubmed/16566889" target="_blank">16566889</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/7543219">Congenital indifference to pain: long-term follow-up of two cases.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Hirsch E,
|
||
Moye D,
|
||
Dimon JH 3rd</span><br />
|
||
<span class="medgenPMjournal">South Med J</span>
|
||
1995 Aug;88(8):851-7.
|
||
doi: 10.1097/00007611-199508000-00014.
|
||
<span class="bold">PMID: </span><a href="/pubmed/7543219" target="_blank">7543219</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Congenital%20Indifference%20to%20Pain%22%20AND%20Prognosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (6)</a></div><h3 class="subhead">Clinical prediction guides</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/23364568">A single-nucleotide polymorphism in SCN9A may decrease postoperative pain sensitivity in the general population.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Duan G,
|
||
Xiang G,
|
||
Zhang X,
|
||
Yuan R,
|
||
Zhan H,
|
||
Qi D</span><br />
|
||
<span class="medgenPMjournal">Anesthesiology</span>
|
||
2013 Feb;118(2):436-42.
|
||
doi: 10.1097/ALN.0b013e31827dde74.
|
||
<span class="bold">PMID: </span><a href="/pubmed/23364568" target="_blank">23364568</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/21939494">Two novel SCN9A gene heterozygous mutations may cause partial deletion of pain perception.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Yuan R,
|
||
Zhang X,
|
||
Deng Q,
|
||
Si D,
|
||
Wu Y,
|
||
Gao F,
|
||
Zhou B</span><br />
|
||
<span class="medgenPMjournal">Pain Med</span>
|
||
2011 Oct;12(10):1510-4.
|
||
Epub 2011 Sep 21
|
||
doi: 10.1111/j.1526-4637.2011.01237.x.
|
||
<span class="bold">PMID: </span><a href="/pubmed/21939494" target="_blank">21939494</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Congenital%20Indifference%20to%20Pain%22%20AND%20Clinical%20prediction%20guides%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (2)</a></div></div>
|
||
</div>
|
||
</div></div></div></div></div></div></div>
|
||
<div id="messagearea_bottom">
|
||
|
||
</div>
|
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<div class=" bottom">
|
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<div class="portlet_content ln"><ul class="a_poppers"><li><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(congenital%20indifference%20to%20pain)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">PubMed</a><div class="help-popup">See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div></li><li><a target="_blank" href="/books/?term=((%22clinical%20guidelines%22%5BResource%20Type%5D)%20OR%20%22practice%20guideline%22%5BPublication%20Type%5D)%20AND%20(%22Congenital%20Indifference%20to%20Pain%22)">Bookshelf</a><div class="help-popup">See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div></li></ul></div>
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<a class="htb ralinkpopperctrl" ref="log$=activity&linkpos=1" href="/portal/utils/pageresolver.fcgi?recordid=67cb4c1ea68b6b5afc528cbf">Congenital Indifference to Pain</a>
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