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<!--
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UID=9730
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ConceptID=C0023467
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-->
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<!--imgCountBooks = 0--><h1 class="medgenTitle"><div class="MedGenTitleText">Acute myeloid leukemia<span class="h1sub">(AML)</span></div></h1><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>9730</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information."><span class="highlight" style="background-color:">C0023467</span></a></dd><dt><span class="dotprefix"> •</span></dt><dd>Neoplastic Process</dd></dl></div></div><table class="medgenTable"><tbody><tr><td>Synonyms:</td>
|
||
<td>Acute granulocytic leukemia; Acute myelogenous leukemia; Acute myeloid leukemia, adult; Acute non-lymphocytic leukemia; AML; AML adult; Familial Acute Myelocytic Leukemia; Leukemia, acute myelogenous, somatic; Leukemia, acute myeloid, somatic</td></tr>
|
||
<tr><td><span class="bold">SNOMED CT: </span></td>
|
||
<td>Acute myeloid leukemia (91861009); AML - Acute myeloblastic leukemia (91861009); Acute myelocytic leukemia (91861009); Acute non-lymphocytic leukemia (1162928000); Acute myelogenous leukemia (1162928000); Acute granulocytic leukemia (1162928000); Acute myelocytic leukemia (1162928000); Acute myeloid leukemia (1162928000); AML - Acute myeloid leukemia (91861009); Acute myeloid leukemia, disease (91861009)</td></tr>
|
||
<tr><td colspan="2" class="small"> </td></tr><tr><td><a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#target-gene-loc">Genes (locations):<img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a><div class="display-none" id="target-gene-loc">
|
||
Gene(s) directly associated with<br />
|
||
this condition or phenotype.</div></td>
|
||
<td><a target="_blank" title="CEBPA - ID: 1050 - NCBI Gene" href="/gene/1050" class="medgenPMinfo">CEBPA</a> (19q13.11); <a target="_blank" title="CHIC2 - ID: 26511 - NCBI Gene" href="/gene/26511" class="medgenPMinfo">CHIC2</a> (4q12); <a target="_blank" title="DNMT3A - ID: 1788 - NCBI Gene" href="/gene/1788" class="medgenPMinfo">DNMT3A</a> (2p23.3); <a target="_blank" title="ETV6 - ID: 2120 - NCBI Gene" href="/gene/2120" class="medgenPMinfo">ETV6</a> (12p13.2); <a target="_blank" title="FLT3 - ID: 2322 - NCBI Gene" href="/gene/2322" class="medgenPMinfo">FLT3</a> (13q12.2); <a target="_blank" title="GATA2 - ID: 2624 - NCBI Gene" href="/gene/2624" class="medgenPMinfo">GATA2</a> (3q21.3); <a target="_blank" title="JAK2 - ID: 3717 - NCBI Gene" href="/gene/3717" class="medgenPMinfo">JAK2</a> (9p24.1); <a target="_blank" title="KIT - ID: 3815 - NCBI Gene" href="/gene/3815" class="medgenPMinfo">KIT</a> (4q12); <a target="_blank" title="KRAS - ID: 3845 - NCBI Gene" href="/gene/3845" class="medgenPMinfo">KRAS</a> (12p12.1); <a target="_blank" title="LPP - ID: 4026 - NCBI Gene" href="/gene/4026" class="medgenPMinfo">LPP</a> (3q27.3-28); <a target="_blank" title="MLLT10 - ID: 8028 - NCBI Gene" href="/gene/8028" class="medgenPMinfo">MLLT10</a> (10p12.31); <a target="_blank" title="NPM1 - ID: 4869 - NCBI Gene" href="/gene/4869" class="medgenPMinfo">NPM1</a> (5q35.1); <a target="_blank" title="NUP214 - ID: 8021 - NCBI Gene" href="/gene/8021" class="medgenPMinfo">NUP214</a> (9q34.13); <a target="_blank" title="PICALM - ID: 8301 - NCBI Gene" href="/gene/8301" class="medgenPMinfo">PICALM</a> (11q14.2); <a target="_blank" title="RUNX1 - ID: 861 - NCBI Gene" href="/gene/861" class="medgenPMinfo">RUNX1</a> (21q22.12); <a target="_blank" title="SH3GL1 - ID: 6455 - NCBI Gene" href="/gene/6455" class="medgenPMinfo">SH3GL1</a> (19p13.3); <a target="_blank" title="TERT - ID: 7015 - NCBI Gene" href="/gene/7015" class="medgenPMinfo">TERT</a> (5p15.33)</td></tr>
|
||
<tr><td colspan="2" class="small"> </td></tr><tr><td>HPO:</td>
|
||
<td><a target="_blank" title="Human Phenotype Ontology" href="https://hpo.jax.org/app/browse/term/HP:0004808">HP:0004808</a></td></tr>
|
||
<tr><td>Monarch Initiative:</td>
|
||
<td><a href="https://monarchinitiative.org/disease/MONDO:0018874" target="_blank">MONDO:0018874</a></td></tr>
|
||
<tr><td>OMIM<span class="superscript">®</span>:</td>
|
||
<td><a href="https://omim.org/entry/601626" target="_blank">601626</a></td></tr>
|
||
<tr><td>Orphanet:</td>
|
||
<td><a target="_blank" title="Orphanet: The portal for rare diseases and orphan drugs" href="http://www.orpha.net/consor/cgi-bin/OC_Exp.php?lng=EN&Expert=519">ORPHA519</a></td></tr></tbody></table></div><div class="rprt-body jig-ncbiinpagenav" data-jigconfig="smoothScroll: false, gotoTopLink: true, gotoTopLinkText: '', gotoTopLinkAttrs: {'title': 'Go to the top of the page'},allHeadingLevels: ['h1'], topOfPageTOC: true, tocId: 'my-toc'"><div id="rprt-tabs-1" class="rprt-tab"><div id="tb-termsProp-1"><div class="leftCol mgCol"><div>
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<div class="portlet mgSection" id="ID_100">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Definition">Definition</h1><a sid="100" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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||
<div class="portlet_content ln">A form of leukemia characterized by overproduction of an early myeloid cell. [from <a title="Human Phenotype Ontology" href="http://www.human-phenotype-ontology.org" class="defSource" target="_blank">HPO</a>]</div>
|
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</div>
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<div class="portlet mgSection" id="ID_117">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Additional_descriptions">Additional descriptions</h1><a sid="117" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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||
<div class="portlet_content ln"><div class="mgSection"><strong>From GeneReviews</strong><br />CEBPA-associated familial acute myeloid leukemia (AML) is defined as the presence of a heterozygous germline CEBPA pathogenic variant in an individual with AML and/or family in which more than one individual has AML. In contrast, sporadic CEBPA-associated AML is defined as AML in which a CEBPA pathogenic variant(s) is identified in leukemic cells but not in the non-leukemic cells. In the majority of individuals, the age of onset of familial AML appears to be earlier than sporadic AML; disease onset has been reported in persons as young as age 1.8 years and up to age 50 years. The prognosis of CEBPA-associated familial AML appears to be favorable compared with sporadic CEBPA-associated AML. Individuals with CEBPA-associated familial AML who have been cured of their initial disease may be at greater risk of developing additional independent leukemic episodes, in addition to the risk of relapse from preexisting clones.</div><div class="mgSection"><strong>From MedlinePlus Genetics</strong><br />Core binding factor acute myeloid leukemia (CBF-AML) is one form of a cancer of the blood-forming tissue (bone marrow) called acute myeloid leukemia. In normal bone marrow, early blood cells called hematopoietic stem cells develop into several types of blood cells: white blood cells (leukocytes) that protect the body from infection, red blood cells (erythrocytes) that carry oxygen, and platelets (thrombocytes) that are involved in blood clotting. In acute myeloid leukemia, the bone marrow makes large numbers of abnormal, immature white blood cells called myeloid blasts. Instead of developing into normal white blood cells, the myeloid blasts develop into cancerous leukemia cells. The large number of abnormal cells in the bone marrow interferes with the production of functional white blood cells, red blood cells, and platelets.<br /><br />People with CBF-AML have a shortage of all types of mature blood cells: a shortage of white blood cells (leukopenia) leads to increased susceptibility to infections, a low number of red blood cells (anemia) causes fatigue and weakness, and a reduction in the amount of platelets (thrombocytopenia) can result in easy bruising and abnormal bleeding. Other symptoms of CBF-AML may include fever and weight loss.<br /><br />While acute myeloid leukemia is generally a disease of older adults, CBF-AML often begins in young adulthood and can occur in childhood. Compared to other forms of acute myeloid leukemia, CBF-AML has a relatively good prognosis: about 90 percent of individuals with CBF-AML recover from their disease following treatment, compared with 25 to 40 percent of those with other forms of acute myeloid leukemia. However, the disease recurs in approximately half of them after successful treatment of the initial occurrence. <a target="_blank" href="https://medlineplus.gov/genetics/condition/core-binding-factor-acute-myeloid-leukemia">https://medlineplus.gov/genetics/condition/core-binding-factor-acute-myeloid-leukemia</a></div><div class="mgSection"><strong>From MedlinePlus Genetics</strong><br />Familial acute myeloid leukemia with mutated CEBPA is one form of a cancer of the blood-forming tissue (bone marrow) called acute myeloid leukemia. In normal bone marrow, early blood cells called hematopoietic stem cells develop into several types of blood cells: white blood cells (leukocytes) that protect the body from infection; red blood cells (erythrocytes) that carry oxygen; and platelets (thrombocytes), which are involved in blood clotting. In acute myeloid leukemia, the bone marrow makes large numbers of abnormal, immature white blood cells called myeloid blasts. Instead of developing into normal white blood cells, the myeloid blasts develop into cancerous leukemia cells. The large number of abnormal cells in the bone marrow interferes with the production of functional white blood cells, red blood cells, and platelets.<br /><br />People with familial acute myeloid leukemia with mutated CEBPA have a shortage of white blood cells (leukopenia), leading to increased susceptibility to infections. A low number of red blood cells (anemia) also occurs in this disorder, resulting in fatigue and weakness. Affected individuals also have a reduction in the amount of platelets (thrombocytopenia), which can result in easy bruising and abnormal bleeding. Other symptoms of familial acute myeloid leukemia with mutated CEBPA may include fever and weight loss.<br /><br />While acute myeloid leukemia is generally a disease of older adults, familial acute myeloid leukemia with mutated CEBPA often begins earlier in life, and it has been reported to occur as early as age 4. Between 50 and 65 percent of affected individuals survive their disease, compared with 25 to 40 percent of those with other forms of acute myeloid leukemia. However, people with familial acute myeloid leukemia with mutated CEBPA have a higher risk of having a new primary occurrence of this disorder after successful treatment of the initial occurrence. <a target="_blank" href="https://medlineplus.gov/genetics/condition/familial-acute-myeloid-leukemia-with-mutated-cebpa">https://medlineplus.gov/genetics/condition/familial-acute-myeloid-leukemia-with-mutated-cebpa</a></div><div class="mgSection"><strong>From MedlinePlus Genetics</strong><br />Cytogenetically normal acute myeloid leukemia (CN-AML) is one form of a cancer of the blood-forming tissue (bone marrow) called acute myeloid leukemia. In normal bone marrow, early blood cells called hematopoietic stem cells develop into several types of blood cells: white blood cells (leukocytes) that protect the body from infection, red blood cells (erythrocytes) that carry oxygen, and platelets (thrombocytes) that are involved in blood clotting. In acute myeloid leukemia, the bone marrow makes large numbers of abnormal, immature white blood cells called myeloid blasts. Instead of developing into normal white blood cells, the myeloid blasts develop into cancerous leukemia cells. The large number of abnormal cells in the bone marrow interferes with the production of functional white blood cells, red blood cells, and platelets.<br /><br />People with CN-AML have a shortage of all types of mature blood cells: a shortage of white blood cells (leukopenia) leads to increased susceptibility to infections, a low number of red blood cells (anemia) causes fatigue and weakness, and a reduction in the amount of platelets (thrombocytopenia) can result in easy bruising and abnormal bleeding. Other symptoms of CN-AML may include fever and weight loss.<br /><br />The age at which CN-AML begins ranges from childhood to late adulthood. CN-AML is said to be an intermediate-risk cancer because the prognosis varies: some affected individuals respond well to normal treatment while others may require stronger treatments. The age at which the condition begins and the prognosis are affected by the specific genetic factors involved in the condition. <a target="_blank" href="https://medlineplus.gov/genetics/condition/cytogenetically-normal-acute-myeloid-leukemia">https://medlineplus.gov/genetics/condition/cytogenetically-normal-acute-myeloid-leukemia</a></div></div>
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Clinical_features">Clinical features</h1><a sid="102" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="portlet_content ln clinfeat"><strong>From HPO</strong><br />
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<div class="divPopper rprt" id="clin_9730"><div><strong>Acute myeloid leukemia</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>9730</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information."><span class="highlight" style="background-color:">C0023467</span></a></dd><dt><span class="dotprefix"> •</span></dt><dd>Neoplastic Process</dd></dl></div></div></div>
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<div class="spaceAbove">A form of leukemia characterized by overproduction of an early myeloid cell.</div>
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<div class="spaceAbove nowrap">See: <a href="/medgen/9730">Feature record</a> | <a href="/medgen?term=%22Acute%20myeloid%20leukemia%22%5BClinical%20Features%5D%20OR%209730%5Buid%5D">Search on this feature</a></div></div><div class="TreeLite"><ul><li><span class="TLline">Neoplasm</span><ul><li class="TLline">
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<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_9730" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Acute myeloid leukemia</a></span></li></ul></li></ul></div></div>
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Term_Hierarchy">Term Hierarchy</h1><a sid="118" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="portlet_content ln HierarchyGTR"><div class="jig-ncbitabs"><ul><li><a href="#tabGTR">GTR</a></li><li><a href="#tabMGEN">MeSH</a></li><li><a href="#tabORDO">Orphanet</a></li></ul><div id="tabGTR"><div class="search_result"><div class="rprts"><div class="chiclet_legend"><span class="chiclet_list" style="position:static;"><span title="Clinical test" class="chiclet Ccolor round">C</span><span>Clinical test, </span><span title="Research test" class="chiclet Rcolor round">R</span><span>Research test, </span><span title="OMIM" class="chiclet Ocolor ">O</span><span>OMIM, </span><span title="GeneReview" class="chiclet Gcolor">G</span><span><em>GeneReviews</em>, </span><span title="ClinVar" class="chiclet Vcolor">V</span><span>ClinVar </span></span></div><div id="hierarchy" class="margin_t1"><div class="ds_tree"><ul><li class="matched_ds"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C0023467[DISCUI]&test_type=Clinical" ref="ncbi_uid=9730">C</a></span><span class="chiclet Rcolor round" title="Research test"><a target="_blank" href="/gtr/tests/?term=C0023467[DISCUI]&test_type=Research&redirect=true" ref="ncbi_uid=9730">R</a></span><span class="chiclet Ocolor" title="OMIM"><a ref="ncbi_uid=9730" target="_blank" href="/omim/116897">O</a></span><span class="chiclet Gcolor" title="GeneReviews"><a target="_blank" href="/books/?term=(NBK47457%20OR%20NBK564234%20OR%20NBK568319%20OR%20NBK574843)%20AND%20gene%5Bbook%5D&showtype=onebook" ref="ncbi_uid=9730">G</a></span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&from_uid=9730" ref="ncbi_uid=9730">V</a></span></span><span class="TLline">Acute myeloid leukemia</span></li></ul></div></div></div></div></div><div id="tabMGEN"><div class="ds_tree"><ul><li><span class="TLline"><a href="/medgen/232130" ref="tree=MeSH" title="MedGen record for Disorder by Site">Disorder by Site</a></span><ul><li><span class="TLline"><a href="/medgen/208860" ref="tree=MeSH" title="MedGen record for Hematopoietic and Lymphatic System Disorder">Hematopoietic and Lymphatic System Disorder</a></span><ul><li><span class="TLline"><a href="/medgen/5483" ref="tree=MeSH" title="MedGen record for Hematologic disorder">Hematologic disorder</a></span><ul><li><span class="TLline"><a href="/medgen/138213" ref="tree=MeSH" title="MedGen record for Hematologic neoplasm">Hematologic neoplasm</a></span><ul><li><span class="TLline"><a href="/medgen/9725" ref="tree=MeSH" title="MedGen record for Leukemia">Leukemia</a></span><ul><li><span class="TLline"><a href="/medgen/43225" ref="tree=MeSH" title="MedGen record for Acute leukemia">Acute leukemia</a></span><ul><li><span class="matched_ds">Acute myeloid leukemia</span><ul><li><span class="TLline"><a href="/medgen/7314" ref="tree=MeSH" title="MedGen record for Acute basophilic leukemia">Acute basophilic leukemia</a></span><ul><li><span class="TLline"><a href="/medgen/124637" ref="tree=MeSH" title="MedGen record for Adult Acute Basophilic Leukemia">Adult Acute Basophilic Leukemia</a></span></li><li><span class="TLline"><a href="/medgen/83536" ref="tree=MeSH" title="MedGen record for Childhood Acute Basophilic Leukemia">Childhood Acute Basophilic Leukemia</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/44121" ref="tree=MeSH" title="MedGen record for Acute Eosinophilic Leukemia">Acute Eosinophilic Leukemia</a></span><ul><li><span class="TLline"><a href="/medgen/76005" ref="tree=MeSH" title="MedGen record for Adult Acute Eosinophilic Leukemia">Adult Acute Eosinophilic Leukemia</a></span></li><li><span class="TLline"><a href="/medgen/79022" ref="tree=MeSH" title="MedGen record for Childhood Acute Eosinophilic Leukemia">Childhood Acute Eosinophilic Leukemia</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/44124" ref="tree=MeSH" title="MedGen record for Acute megakaryoblastic leukemia">Acute megakaryoblastic leukemia</a></span><ul><li><span class="TLline"><a href="/medgen/79016" ref="tree=MeSH" title="MedGen record for Acute megakaryoblastic leukemia in adult">Acute megakaryoblastic leukemia in adult</a></span></li><li><span class="TLline"><a href="/medgen/1863778" ref="tree=MeSH" title="MedGen record for Acute megakaryoblastic leukemia in down syndrome">Acute megakaryoblastic leukemia in down syndrome</a></span></li><li><span class="TLline"><a href="/medgen/1843134" ref="tree=MeSH" title="MedGen record for Acute megakaryoblastic leukemia without down syndrome">Acute megakaryoblastic leukemia without down syndrome</a></span></li><li><span class="TLline"><a href="/medgen/79023" ref="tree=MeSH" title="MedGen record for Childhood acute megakaryoblastic leukemia">Childhood acute megakaryoblastic leukemia</a></span></li><li><span class="TLline"><a href="/medgen/1718677" ref="tree=MeSH" title="MedGen record for Recurrent Acute Megakaryoblastic Leukemia">Recurrent Acute Megakaryoblastic Leukemia</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/824521" ref="tree=MeSH" title="MedGen record for Acute Monoblastic and Monocytic Leukemia">Acute Monoblastic and Monocytic Leukemia</a></span><ul><li><span class="TLline"><a href="/medgen/141597" ref="tree=MeSH" title="MedGen record for Acute monoblastic leukemia">Acute monoblastic leukemia</a></span><ul><li><span class="TLline"><a href="/medgen/76004" ref="tree=MeSH" title="MedGen record for Adult Acute Monoblastic Leukemia">Adult Acute Monoblastic Leukemia</a></span></li><li><span class="TLline"><a href="/medgen/124640" ref="tree=MeSH" title="MedGen record for Childhood Acute Monoblastic Leukemia">Childhood Acute Monoblastic Leukemia</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/272289" ref="tree=MeSH" title="MedGen record for Adult Acute Monoblastic and Monocytic Leukemia">Adult Acute Monoblastic and Monocytic Leukemia</a></span><ul><li><span class="TLline"><a href="/medgen/128856" ref="tree=MeSH" title="MedGen record for Adult acute monocytic leukemia">Adult acute monocytic leukemia</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/272456" ref="tree=MeSH" title="MedGen record for Childhood Acute Monoblastic and Monocytic Leukemia">Childhood Acute Monoblastic and Monocytic Leukemia</a></span><ul><li><span class="TLline"><a href="/medgen/79021" ref="tree=MeSH" title="MedGen record for Childhood Acute Monocytic Leukemia">Childhood Acute Monocytic Leukemia</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/1719565" ref="tree=MeSH" title="MedGen record for Recurrent Acute Monoblastic and Monocytic Leukemia">Recurrent Acute Monoblastic and Monocytic Leukemia</a></span></li><li><span class="TLline"><a href="/medgen/1734713" ref="tree=MeSH" title="MedGen record for Refractory Acute Monoblastic and Monocytic Leukemia">Refractory Acute Monoblastic and Monocytic Leukemia</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/7319" ref="tree=MeSH" title="MedGen record for Acute monocytic leukemia">Acute monocytic leukemia</a></span></li><li><span class="TLline"><a href="/medgen/361829" ref="tree=MeSH" title="MedGen record for Acute myeloblastic leukemia with maturation">Acute myeloblastic leukemia with maturation</a></span><ul><li><span class="TLline"><a href="/medgen/83534" ref="tree=MeSH" title="MedGen record for Adult Acute Myeloid Leukemia with Maturation">Adult Acute Myeloid Leukemia with Maturation</a></span></li><li><span class="TLline"><a href="/medgen/124638" ref="tree=MeSH" title="MedGen record for Childhood Acute Myeloid Leukemia with Maturation">Childhood Acute Myeloid Leukemia with Maturation</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/10232" ref="tree=MeSH" title="MedGen record for Acute myeloblastic leukemia without maturation">Acute myeloblastic leukemia without maturation</a></span><ul><li><span class="TLline"><a href="/medgen/83533" ref="tree=MeSH" title="MedGen record for Adult Acute Myeloid Leukemia without Maturation">Adult Acute Myeloid Leukemia without Maturation</a></span></li><li><span class="TLline"><a href="/medgen/79018" ref="tree=MeSH" title="MedGen record for Childhood Acute Myeloid Leukemia without Maturation">Childhood Acute Myeloid Leukemia without Maturation</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/101100" ref="tree=MeSH" title="MedGen record for Acute myeloid leukemia with minimal differentiation">Acute myeloid leukemia with minimal differentiation</a></span><ul><li><span class="TLline"><a href="/medgen/76319" ref="tree=MeSH" title="MedGen record for Adult Acute Myeloid Leukemia with Minimal Differentiation">Adult Acute Myeloid Leukemia with Minimal Differentiation</a></span></li><li><span class="TLline"><a href="/medgen/129065" ref="tree=MeSH" title="MedGen record for Childhood Acute Myeloid Leukemia with Minimal Differentiation">Childhood Acute Myeloid Leukemia with Minimal Differentiation</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/224861" ref="tree=MeSH" title="MedGen record for Acute myeloid leukemia with multilineage dysplasia">Acute myeloid leukemia with multilineage dysplasia</a></span><ul><li><span class="TLline"><a href="/medgen/1649394" ref="tree=MeSH" title="MedGen record for Recurrent Acute Myeloid Leukemia with Multilineage Dysplasia">Recurrent Acute Myeloid Leukemia with Multilineage Dysplasia</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/220899" ref="tree=MeSH" title="MedGen record for Acute myeloid leukemia with recurrent genetic anomaly">Acute myeloid leukemia with recurrent genetic anomaly</a></span><ul><li><span class="TLline"><a href="/medgen/414840" ref="tree=MeSH" title="MedGen record for Acute Myeloid Leukemia (Megakaryoblastic) with t(1;22)(p13.3;q13.1); RBM15-MKL1">Acute Myeloid Leukemia (Megakaryoblastic) with t(1;22)(p13.3;q13.1); RBM15-MKL1</a></span></li><li><span class="TLline"><a href="/medgen/266234" ref="tree=MeSH" title="MedGen record for Acute myeloid leukemia with 11q23 abnormalities">Acute myeloid leukemia with 11q23 abnormalities</a></span><ul><li><span class="TLline"><a href="/medgen/1385022" ref="tree=MeSH" title="MedGen record for Acute Myeloid Leukemia with t(6;11)(q27;q23.3); MLLT4-KMT2A">Acute Myeloid Leukemia with t(6;11)(q27;q23.3); MLLT4-KMT2A</a></span></li><li><span class="TLline"><a href="/medgen/753997" ref="tree=MeSH" title="MedGen record for Acute myeloid leukemia with t(9;11)(p22;q23)">Acute myeloid leukemia with t(9;11)(p22;q23)</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/442905" ref="tree=MeSH" title="MedGen record for Acute Myeloid Leukemia with a Variant RARA Rearrangement">Acute Myeloid Leukemia with a Variant RARA Rearrangement</a></span><ul><li><span class="TLline"><a href="/medgen/442907" ref="tree=MeSH" title="MedGen record for Acute Myeloid Leukemia with t(11;17)(q13;q21); NUMA1-RARA">Acute Myeloid Leukemia with t(11;17)(q13;q21); NUMA1-RARA</a></span></li><li><span class="TLline"><a href="/medgen/442906" ref="tree=MeSH" title="MedGen record for Acute Myeloid Leukemia with t(11;17)(q23;q21); ZBTB16-RARA">Acute Myeloid Leukemia with t(11;17)(q23;q21); ZBTB16-RARA</a></span></li><li><span class="TLline"><a href="/medgen/888782" ref="tree=MeSH" title="MedGen record for Acute Myeloid Leukemia with t(5;17)(q35;q21); NPM1-RARA">Acute Myeloid Leukemia with t(5;17)(q35;q21); NPM1-RARA</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/1716406" ref="tree=MeSH" title="MedGen record for Acute myeloid leukemia with abnormal bone marrow eosinophils inv(16)(p13q22) or t(16;16)(p13;q22)">Acute myeloid leukemia with abnormal bone marrow eosinophils inv(16)(p13q22) or t(16;16)(p13;q22)</a></span><ul><li><span class="TLline"><a href="/medgen/323471" ref="tree=MeSH" title="MedGen record for Acute Myeloid Leukemia with inv(16)(p13.1q22); CBFB-MYH11">Acute Myeloid Leukemia with inv(16)(p13.1q22); CBFB-MYH11</a></span></li><li><span class="TLline"><a href="/medgen/231354" ref="tree=MeSH" title="MedGen record for Acute Myeloid Leukemia with t(16;16)(p13.1;q22); CBFB-MYH11">Acute Myeloid Leukemia with t(16;16)(p13.1;q22); CBFB-MYH11</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/1377153" ref="tree=MeSH" title="MedGen record for Acute myeloid leukemia with BCR-ABL1">Acute myeloid leukemia with BCR-ABL1</a></span></li><li><span class="TLline"><a href="/medgen/1640289" ref="tree=MeSH" title="MedGen record for Acute myeloid leukemia with CEBPA somatic mutations">Acute myeloid leukemia with CEBPA somatic mutations</a></span><ul><li><span class="TLline"><a href="/medgen/1381306" ref="tree=MeSH" title="MedGen record for Acute Myeloid Leukemia with Monoallelic CEBPA Mutation">Acute Myeloid Leukemia with Monoallelic CEBPA Mutation</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/414839" ref="tree=MeSH" title="MedGen record for Acute myeloid leukemia with DEK::NUP214 fusion">Acute myeloid leukemia with DEK::NUP214 fusion</a></span></li><li><span class="TLline"><a href="/medgen/415269" ref="tree=MeSH" title="MedGen record for Acute myeloid leukemia with inv3(p21;q26.2) or t(3;3)(p21;q26.2)">Acute myeloid leukemia with inv3(p21;q26.2) or t(3;3)(p21;q26.2)</a></span><ul><li><span class="TLline"><a href="/medgen/887633" ref="tree=MeSH" title="MedGen record for Acute Myeloid Leukemia with inv(3) (q21.3;q26.2); GATA2, MECOM">Acute Myeloid Leukemia with inv(3) (q21.3;q26.2); GATA2, MECOM</a></span></li><li><span class="TLline"><a href="/medgen/884781" ref="tree=MeSH" title="MedGen record for Acute Myeloid Leukemia with t(3;3) (q21.3;q26.2); GATA2, MECOM">Acute Myeloid Leukemia with t(3;3) (q21.3;q26.2); GATA2, MECOM</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/1376688" ref="tree=MeSH" title="MedGen record for Acute myeloid leukemia with t(8;16)(p11;p13) translocation">Acute myeloid leukemia with t(8;16)(p11;p13) translocation</a></span></li><li><span class="TLline"><a href="/medgen/224862" ref="tree=MeSH" title="MedGen record for Acute myeloid leukemia with t(8;21)(q22;q22) translocation">Acute myeloid leukemia with t(8;21)(q22;q22) translocation</a></span><ul><li><span class="TLline"><a href="/medgen/417002" ref="tree=MeSH" title="MedGen record for Adult Acute Myeloid Leukemia with t(8;21); (q22; q22.1); RUNX1-RUNX1T1">Adult Acute Myeloid Leukemia with t(8;21); (q22; q22.1); RUNX1-RUNX1T1</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/1696774" ref="tree=MeSH" title="MedGen record for Acute Myeloid Leukemia with Trisomy 8">Acute Myeloid Leukemia with Trisomy 8</a></span></li><li><span class="TLline"><a href="/medgen/44127" ref="tree=MeSH" title="MedGen record for Acute promyelocytic leukemia">Acute promyelocytic leukemia</a></span><ul><li><span class="TLline"><a href="/medgen/83535" ref="tree=MeSH" title="MedGen record for Adult Acute Promyelocytic Leukemia with t(15;17)(q24.1;q21.2); PML-RARA">Adult Acute Promyelocytic Leukemia with t(15;17)(q24.1;q21.2); PML-RARA</a></span></li><li><span class="TLline"><a href="/medgen/79020" ref="tree=MeSH" title="MedGen record for Childhood Acute Promyelocytic Leukemia with t(15;17)(q24.1;q21.2); PML-RARA">Childhood Acute Promyelocytic Leukemia with t(15;17)(q24.1;q21.2); PML-RARA</a></span></li><li><span class="TLline"><a href="/medgen/108266" ref="tree=MeSH" title="MedGen record for Microgranular Acute Promyelocytic Leukemia">Microgranular Acute Promyelocytic Leukemia</a></span></li><li><span class="TLline"><a href="/medgen/1741304" ref="tree=MeSH" title="MedGen record for Recurrent Acute Promyelocytic Leukemia with t(15;17)(q24.1;q21.2); PML-RARA">Recurrent Acute Promyelocytic Leukemia with t(15;17)(q24.1;q21.2); PML-RARA</a></span></li><li><span class="TLline"><a href="/medgen/578867" ref="tree=MeSH" title="MedGen record for Typical Acute Promyelocytic Leukemia">Typical Acute Promyelocytic Leukemia</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/389485" ref="tree=MeSH" title="MedGen record for Adult Acute Myeloid Leukemia with Recurrent Genetic Abnormalities">Adult Acute Myeloid Leukemia with Recurrent Genetic Abnormalities</a></span><ul><li><span class="TLline"><a href="/medgen/414571" ref="tree=MeSH" title="MedGen record for Adult Acute Myeloid Leukemia with inv(16)(p13.1q22); CBFB-MYH11">Adult Acute Myeloid Leukemia with inv(16)(p13.1q22); CBFB-MYH11</a></span></li><li><span class="TLline"><a href="/medgen/323797" ref="tree=MeSH" title="MedGen record for Adult Acute Myeloid Leukemia with t(16;16)(p13.1;q22); CBFB-MYH11">Adult Acute Myeloid Leukemia with t(16;16)(p13.1;q22); CBFB-MYH11</a></span></li><li><span class="TLline"><a href="/medgen/280999" ref="tree=MeSH" title="MedGen record for Adult Acute Myeloid Leukemia with t(9;11)(p21.3;q23.3); MLLT3-KMT2A">Adult Acute Myeloid Leukemia with t(9;11)(p21.3;q23.3); MLLT3-KMT2A</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/825586" ref="tree=MeSH" title="MedGen record for Core binding factor acute myeloid leukemia">Core binding factor acute myeloid leukemia</a></span></li><li><span class="TLline"><a href="/medgen/1638466" ref="tree=MeSH" title="MedGen record for Megakaryoblastic acute myeloid leukemia with t(1;22)(p13;q13)">Megakaryoblastic acute myeloid leukemia with t(1;22)(p13;q13)</a></span></li><li><span class="TLline"><a href="/medgen/1665215" ref="tree=MeSH" title="MedGen record for Recurrent Acute Myeloid Leukemia with Recurrent Genetic Abnormalities">Recurrent Acute Myeloid Leukemia with Recurrent Genetic Abnormalities</a></span><ul><li><span class="TLline"><a href="/medgen/1654885" ref="tree=MeSH" title="MedGen record for Recurrent Acute Myeloid Leukemia with t(9;11)(p21.3;q23.3); MLLT3-KMT2A">Recurrent Acute Myeloid Leukemia with t(9;11)(p21.3;q23.3); MLLT3-KMT2A</a></span></li></ul></li></ul></li><li><span class="TLline"><a href="/medgen/7316" ref="tree=MeSH" title="MedGen record for Acute myeloid leukemia, M6 type">Acute myeloid leukemia, M6 type</a></span><ul><li><span class="TLline"><a href="/medgen/79015" ref="tree=MeSH" title="MedGen record for Adult Acute Erythroid Leukemia">Adult Acute Erythroid Leukemia</a></span><ul><li><span class="TLline"><a href="/medgen/389533" ref="tree=MeSH" title="MedGen record for Adult Erythroleukemia">Adult Erythroleukemia</a></span></li><li><span class="TLline"><a href="/medgen/417053" ref="tree=MeSH" title="MedGen record for Adult Pure Erythroid Leukemia">Adult Pure Erythroid Leukemia</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/232341" ref="tree=MeSH" title="MedGen record for Childhood Acute Erythroid Leukemia">Childhood Acute Erythroid Leukemia</a></span></li><li><span class="TLline"><a href="/medgen/1614281" ref="tree=MeSH" title="MedGen record for Erythroleukemia">Erythroleukemia</a></span></li><li><span class="TLline"><a href="/medgen/1790819" ref="tree=MeSH" title="MedGen record for Erythroleukemia, familial, susceptibility to">Erythroleukemia, familial, susceptibility to</a></span></li><li><span class="TLline"><a href="/medgen/1626382" ref="tree=MeSH" title="MedGen record for Pure Erythroid Leukemia">Pure Erythroid Leukemia</a></span></li><li><span class="TLline"><a href="/medgen/1669222" ref="tree=MeSH" title="MedGen record for Recurrent Acute Erythroid Leukemia">Recurrent Acute Erythroid Leukemia</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/414578" ref="tree=MeSH" title="MedGen record for Acute Myeloid Leukemia, Myelodysplasia-Related">Acute Myeloid Leukemia, Myelodysplasia-Related</a></span><ul><li><span class="TLline"><a href="/medgen/231352" ref="tree=MeSH" title="MedGen record for Acute Myeloid Leukemia Arising from Previous Myelodysplastic Syndrome">Acute Myeloid Leukemia Arising from Previous Myelodysplastic Syndrome</a></span></li><li><span class="TLline"><a href="/medgen/902081" ref="tree=MeSH" title="MedGen record for Recurrent Acute Myeloid Leukemia, Myelodysplasia-Related">Recurrent Acute Myeloid Leukemia, Myelodysplasia-Related</a></span></li><li><span class="TLline"><a href="/medgen/1793142" ref="tree=MeSH" title="MedGen record for Refractory Acute Myeloid Leukemia, Myelodysplasia-Related">Refractory Acute Myeloid Leukemia, Myelodysplasia-Related</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/9732" ref="tree=MeSH" title="MedGen record for Acute myelomonocytic leukemia M4">Acute myelomonocytic leukemia M4</a></span><ul><li><span class="TLline"><a href="/medgen/272281" ref="tree=MeSH" title="MedGen record for Acute Myelomonocytic Leukemia with Abnormal Eosinophils">Acute Myelomonocytic Leukemia with Abnormal Eosinophils</a></span></li><li><span class="TLline"><a href="/medgen/310448" ref="tree=MeSH" title="MedGen record for Acute Myelomonocytic Leukemia without Abnormal Eosinophils">Acute Myelomonocytic Leukemia without Abnormal Eosinophils</a></span></li><li><span class="TLline"><a href="/medgen/76003" ref="tree=MeSH" title="MedGen record for Adult Acute Myelomonocytic Leukemia">Adult Acute Myelomonocytic Leukemia</a></span></li><li><span class="TLline"><a href="/medgen/124639" ref="tree=MeSH" title="MedGen record for Childhood Acute Myelomonocytic Leukemia">Childhood Acute Myelomonocytic Leukemia</a></span></li><li><span class="TLline"><a href="/medgen/1712090" ref="tree=MeSH" title="MedGen record for Recurrent Acute Myelomonocytic Leukemia">Recurrent Acute Myelomonocytic Leukemia</a></span></li><li><span class="TLline"><a href="/medgen/1758507" ref="tree=MeSH" title="MedGen record for Refractory Acute Myelomonocytic Leukemia">Refractory Acute Myelomonocytic Leukemia</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/87279" ref="tree=MeSH" title="MedGen record for Acute panmyelosis with myelofibrosis">Acute panmyelosis with myelofibrosis</a></span></li><li><span class="TLline"><a href="/medgen/113092" ref="tree=MeSH" title="MedGen record for Adult Acute Myeloid Leukemia">Adult Acute Myeloid Leukemia</a></span><ul><li><span class="TLline"><a href="/medgen/82982" ref="tree=MeSH" title="MedGen record for Recurrent Adult Acute Myeloid Leukemia">Recurrent Adult Acute Myeloid Leukemia</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/65075" ref="tree=MeSH" title="MedGen record for Childhood acute myeloid leukemia">Childhood acute myeloid leukemia</a></span><ul><li><span class="TLline"><a href="/medgen/1389170" ref="tree=MeSH" title="MedGen record for Acute Megakaryoblastic Leukemia with CBFA2T3-GLIS2">Acute Megakaryoblastic Leukemia with CBFA2T3-GLIS2</a></span></li><li><span class="TLline"><a href="/medgen/1714533" ref="tree=MeSH" title="MedGen record for Acute Myeloid Leukemia with RAM Immunophenotype">Acute Myeloid Leukemia with RAM Immunophenotype</a></span></li><li><span class="TLline"><a href="/medgen/888328" ref="tree=MeSH" title="MedGen record for Acute Myeloid Leukemia with t(7;12)(q36;p13); HLXB9-ETV6">Acute Myeloid Leukemia with t(7;12)(q36;p13); HLXB9-ETV6</a></span></li><li><span class="TLline"><a href="/medgen/889446" ref="tree=MeSH" title="MedGen record for Childhood Acute Myeloid Leukemia Not Otherwise Specified">Childhood Acute Myeloid Leukemia Not Otherwise Specified</a></span></li><li><span class="TLline"><a href="/medgen/881978" ref="tree=MeSH" title="MedGen record for Childhood Acute Myeloid Leukemia with Abnormalities of Chromosome 7">Childhood Acute Myeloid Leukemia with Abnormalities of Chromosome 7</a></span></li><li><span class="TLline"><a href="/medgen/888150" ref="tree=MeSH" title="MedGen record for Childhood Acute Myeloid Leukemia with Abnormalities of Chromosome 5q">Childhood Acute Myeloid Leukemia with Abnormalities of Chromosome 5q</a></span></li><li><span class="TLline"><a href="/medgen/884951" ref="tree=MeSH" title="MedGen record for Childhood Acute Myeloid Leukemia with NUP98 Rearrangement">Childhood Acute Myeloid Leukemia with NUP98 Rearrangement</a></span></li><li><span class="TLline"><a href="/medgen/82981" ref="tree=MeSH" title="MedGen record for Recurrent Childhood Acute Myeloid Leukemia">Recurrent Childhood Acute Myeloid Leukemia</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/825713" ref="tree=MeSH" title="MedGen record for Cytogenetically Normal Acute Myeloid Leukemia">Cytogenetically Normal Acute Myeloid Leukemia</a></span></li><li><span class="TLline"><a href="/medgen/1634915" ref="tree=MeSH" title="MedGen record for Inherited acute myeloid leukemia">Inherited acute myeloid leukemia</a></span></li><li><span class="TLline"><a href="/medgen/44123" ref="tree=MeSH" title="MedGen record for Mast cell leukemia">Mast cell leukemia</a></span><ul><li><span class="TLline"><a href="/medgen/1843106" ref="tree=MeSH" title="MedGen record for Acute mast cell leukemia">Acute mast cell leukemia</a></span></li><li><span class="TLline"><a href="/medgen/1843226" ref="tree=MeSH" title="MedGen record for Chronic mast cell leukemia">Chronic mast cell leukemia</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/1661148" ref="tree=MeSH" title="MedGen record for Recurrent Acute Myeloid Leukemia">Recurrent Acute Myeloid Leukemia</a></span><ul><li><span class="TLline"><a href="/medgen/1656787" ref="tree=MeSH" title="MedGen record for Recurrent Acute Myeloid Leukemia Not Otherwise Specified">Recurrent Acute Myeloid Leukemia Not Otherwise Specified</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/1627534" ref="tree=MeSH" title="MedGen record for Refractory Acute Myeloid Leukemia">Refractory Acute Myeloid Leukemia</a></span><ul><li><span class="TLline"><a href="/medgen/1773485" ref="tree=MeSH" title="MedGen record for Refractory Acute Myeloid Leukemia Not Otherwise Specified">Refractory Acute Myeloid Leukemia Not Otherwise Specified</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/76113" ref="tree=MeSH" title="MedGen record for Secondary Acute Myeloid Leukemia">Secondary Acute Myeloid Leukemia</a></span><ul><li><span class="TLline"><a href="/medgen/1760542" ref="tree=MeSH" title="MedGen record for Acute Myeloid Leukemia Arising from Previous Myelodysplastic/Myeloproliferative Neoplasm">Acute Myeloid Leukemia Arising from Previous Myelodysplastic/Myeloproliferative Neoplasm</a></span></li><li><span class="TLline"><a href="/medgen/1766651" ref="tree=MeSH" title="MedGen record for Acute Myeloid Leukemia Arising from Previous Myeloproliferative Neoplasm">Acute Myeloid Leukemia Arising from Previous Myeloproliferative Neoplasm</a></span></li><li><span class="TLline"><a href="/medgen/237008" ref="tree=MeSH" title="MedGen record for Acute Myeloid Leukemia Post Cytotoxic Therapy">Acute Myeloid Leukemia Post Cytotoxic Therapy</a></span><ul><li><span class="TLline"><a href="/medgen/730170" ref="tree=MeSH" title="MedGen record for Alkylating Agent-Related Acute Myeloid Leukemia">Alkylating Agent-Related Acute Myeloid Leukemia</a></span></li><li><span class="TLline"><a href="/medgen/237013" ref="tree=MeSH" title="MedGen record for Topoisomerase II Inhibitor-Related Acute Myeloid Leukemia">Topoisomerase II Inhibitor-Related Acute Myeloid Leukemia</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/234037" ref="tree=MeSH" title="MedGen record for Benzene-Related Acute Myeloid Leukemia">Benzene-Related Acute Myeloid Leukemia</a></span></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></div></div><div id="tabORDO">Follow <a target="_blank" href="http://www.orpha.net/consor/cgi-bin/Disease_Classif.php?lng=EN&data_id=156&PatId=3586&search=Disease_Classif_Simple&new=1" class="ital bold">this link</a> to review classifications for <span class="ital">Acute myeloid leukemia</span> in Orphanet.</div></div></div>
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Conditions_with_this_feature">Conditions with this feature</h1><a sid="112" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="divPopper rprt" id="rdis_9730"><div><strong>Acute myeloid leukemia</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>9730</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information."><span class="highlight" style="background-color:">C0023467</span></a></dd><dt><span class="dotprefix"> •</span></dt><dd>Neoplastic Process</dd></dl></div></div></div>
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<div class="spaceAbove">A form of leukemia characterized by overproduction of an early myeloid cell.</div>
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<div class="spaceAbove nowrap">See: <a href="/medgen/9730">Condition Record</a></div></div>
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<div class="divPopper rprt" id="rdis_216941"><div><strong>Dyskeratosis congenita, X-linked</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>216941</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1148551</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
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<div class="spaceAbove">Dyskeratosis congenita and related telomere biology disorders (DC/TBD) are caused by impaired telomere maintenance resulting in short or very short telomeres. The phenotypic spectrum of telomere biology disorders is broad and includes individuals with classic dyskeratosis congenita (DC) as well as those with very short telomeres and an isolated physical finding. Classic DC is characterized by a triad of dysplastic nails, lacy reticular pigmentation of the upper chest and/or neck, and oral leukoplakia, although this may not be present in all individuals. People with DC/TBD are at increased risk for progressive bone marrow failure (BMF), myelodysplastic syndrome or acute myelogenous leukemia, solid tumors (usually squamous cell carcinoma of the head/neck or anogenital cancer), and pulmonary fibrosis. Other findings can include eye abnormalities (epiphora, blepharitis, sparse eyelashes, ectropion, entropion, trichiasis), taurodontism, liver disease, gastrointestinal telangiectasias, and avascular necrosis of the hips or shoulders. Although most persons with DC/TBD have normal psychomotor development and normal neurologic function, significant developmental delay is present in both forms; additional findings include cerebellar hypoplasia (Hoyeraal Hreidarsson syndrome) and bilateral exudative retinopathy and intracranial calcifications (Revesz syndrome and Coats plus syndrome). Onset and progression of manifestations of DC/TBD vary: at the mild end of the spectrum are those who have only minimal physical findings with normal bone marrow function, and at the severe end are those who have the diagnostic triad and early-onset BMF.</div>
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<div class="spaceAbove nowrap">See: <a href="/medgen/216941">Condition Record</a></div></div>
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<div class="divPopper rprt" id="rdis_321945"><div><strong>Hereditary thrombocytopenia and hematological cancer predisposition syndrome associated with RUNX1</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>321945</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1832388</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
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<div class="spaceAbove">RUNX1 familial platelet disorder with associated myeloid malignancies (RUNX1-FPDMM) is characterized by prolonged bleeding and/or easy bruising and an increased risk of developing a hematologic malignancy. RUNX1-FPDMM is characterized by thrombocytopenia with normal platelet size; bleeding is often greater than expected due to qualitative platelet dysfunction. Myeloid malignancies are the most common, including acute myelogenous leukemia and myelodysplastic syndrome. T- and B-cell acute lymphoblastic leukemias and lymphomas have also been reported, as well as skin manifestations (e.g., eczema, psoriasis).</div>
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<div class="spaceAbove nowrap">See: <a href="/medgen/321945">Condition Record</a></div></div>
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<div class="divPopper rprt" id="rdis_372133"><div><strong>Fanconi anemia complementation group N</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>372133</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1835817</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
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<div class="spaceAbove">Fanconi anemia (FA) is characterized by physical abnormalities, bone marrow failure, and increased risk for malignancy. Physical abnormalities, present in approximately 75% of affected individuals, include one or more of the following: short stature, abnormal skin pigmentation, skeletal malformations of the upper and/or lower limbs, microcephaly, and ophthalmic and genitourinary tract anomalies. Progressive bone marrow failure with pancytopenia typically presents in the first decade, often initially with thrombocytopenia or leukopenia. The incidence of acute myeloid leukemia is 13% by age 50 years. Solid tumors – particularly of the head and neck, skin, and genitourinary tract – are more common in individuals with FA.</div>
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<div class="spaceAbove nowrap">See: <a href="/medgen/372133">Condition Record</a></div></div>
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<div class="divPopper rprt" id="rdis_325420"><div><strong>Fanconi anemia complementation group D1</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>325420</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1838457</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
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<div class="spaceAbove">Fanconi anemia (FA) is characterized by physical abnormalities, bone marrow failure, and increased risk for malignancy. Physical abnormalities, present in approximately 75% of affected individuals, include one or more of the following: short stature, abnormal skin pigmentation, skeletal malformations of the upper and/or lower limbs, microcephaly, and ophthalmic and genitourinary tract anomalies. Progressive bone marrow failure with pancytopenia typically presents in the first decade, often initially with thrombocytopenia or leukopenia. The incidence of acute myeloid leukemia is 13% by age 50 years. Solid tumors – particularly of the head and neck, skin, and genitourinary tract – are more common in individuals with FA.</div>
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<div class="spaceAbove nowrap">See: <a href="/medgen/325420">Condition Record</a></div></div>
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<div class="divPopper rprt" id="rdis_375050"><div><strong>Nonimmune chronic idiopathic neutropenia of adults</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>375050</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1842930</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
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<div class="spaceAbove">Nonimmune chronic idiopathic neutropenia of adults (NI-CINA) is a relatively mild form of neutropenia diagnosed in adults but predisposing to leukemia in a subset of patients (Papadaki et al., 2002).</div>
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<div class="spaceAbove nowrap">See: <a href="/medgen/375050">Condition Record</a></div></div>
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<div class="divPopper rprt" id="rdis_381529"><div><strong>Monosomy 7 myelodysplasia and leukemia syndrome 1</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>381529</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1854978</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
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<div class="spaceAbove">Monosomy 7 myelodysplasia and leukemia syndrome-1 (M7MLS1) is an autosomal dominant hematologic disorder with highly variable manifestations. Most patients present in early childhood with pancytopenia and dyspoietic or dysplastic changes in the bone marrow. These abnormalities are almost always associated with monosomy 7 in the bone marrow. In severely affected individuals, the phenotype progresses to frank myelodysplastic syndrome (MDS) or acute myelogenous leukemia (AML). Less severely affected individuals may have transient thrombocytopenia or anemia, or have normal peripheral blood counts with transient bone marrow abnormalities or transient monosomy 7. Germline mutations in the SAMD9L gene, located on chromosome 7q, have a gain-of-function suppressive effect on the cell cycle, resulting in decreased cellular proliferation. It is hypothesized that this germline defect leads to selective pressure favoring somatic loss of the chromosome 7 harboring the mutant allele (adaptation by aneuploidy) (summary by Wong et al., 2018). Monosomy 7 or partial deletion of the long arm of chromosome 7 (7q-) is a frequent cytogenetic finding in the bone marrow of patients with myelodysplasia and acute myelogenous leukemia. Furthermore, monosomy 7 or 7q- is the most frequent abnormality of karyotype in cases of AML that occur after cytotoxic cancer therapy or occupational exposure to mutagens. The age distribution of de novo cases shows peaks in the first and fifth decades. Monosomy 7 is found in about 5% of de novo and 40% of secondary cases of AML. These findings suggest that loss of certain genes at this region is an important event in the development of myelodysplasia (summary by Shannon et al., 1989). Genetic Heterogeneity of Monosomy 7 Myelodysplastic and Leukemia Syndrome See also M7MLS2 (619041), caused by germline mutation in the SAMD9 gene (610457) on chromosome 7q21.</div>
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<div class="spaceAbove nowrap">See: <a href="/medgen/381529">Condition Record</a></div></div>
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<div class="divPopper rprt" id="rdis_383699"><div><strong>Leukemia, acute myelocytic, with polyposis coli and colon cancer</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>383699</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1855505</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Neoplastic Process</dd></dl></div></div></div>
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<div class="spaceAbove nowrap">See: <a href="/medgen/383699">Condition Record</a></div></div>
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<div class="divPopper rprt" id="rdis_346548"><div><strong>Dohle bodies and leukemia</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>346548</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1857225</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Neoplastic Process</dd></dl></div></div></div>
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<div class="spaceAbove nowrap">See: <a href="/medgen/346548">Condition Record</a></div></div>
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<div class="divPopper rprt" id="rdis_442777"><div><strong>Glioma susceptibility 3</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>442777</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C2751641</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Finding</dd></dl></div></div></div>
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<div class="spaceAbove">Any malignant glioma in which the cause of the disease is a mutation in the BRCA2 gene.</div>
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<div class="spaceAbove nowrap">See: <a href="/medgen/442777">Condition Record</a></div></div>
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<div class="divPopper rprt" id="rdis_481294"><div><strong>Deafness-lymphedema-leukemia syndrome</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>481294</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C3279664</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
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<div class="spaceAbove">Primary lymphedema with myelodysplasia, also known as Emberger syndrome, is a rare disorder characterized by childhood-onset lymphedema of the lower limbs, with lymphoscintigraphy suggestive of lymphatic vessel hypoplasia, and genital lymphatic abnormalities. Myelodysplasia is usually with monosomy 7. Multiple warts, deafness, and minor anomalies (mild hypotelorism, neck webbing, and slender fingers) may also be present (summary by Mansour et al., 2010).</div>
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<div class="spaceAbove nowrap">See: <a href="/medgen/481294">Condition Record</a></div></div>
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<div class="divPopper rprt" id="rdis_896157"><div><strong>Fanconi anemia complementation group T</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>896157</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C4084840</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
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<div class="spaceAbove">Fanconi anemia (FA) is characterized by physical abnormalities, bone marrow failure, and increased risk for malignancy. Physical abnormalities, present in approximately 75% of affected individuals, include one or more of the following: short stature, abnormal skin pigmentation, skeletal malformations of the upper and/or lower limbs, microcephaly, and ophthalmic and genitourinary tract anomalies. Progressive bone marrow failure with pancytopenia typically presents in the first decade, often initially with thrombocytopenia or leukopenia. The incidence of acute myeloid leukemia is 13% by age 50 years. Solid tumors – particularly of the head and neck, skin, and genitourinary tract – are more common in individuals with FA.</div>
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<div class="spaceAbove nowrap">See: <a href="/medgen/896157">Condition Record</a></div></div>
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<div class="divPopper rprt" id="rdis_895780"><div><strong>DDX41-related hematologic malignancy predisposition syndrome</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>895780</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C4225174</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Finding</dd></dl></div></div></div>
|
||
<div class="spaceAbove">DDX41-associated familial myelodysplastic syndrome and acute myeloid leukemia (MDS/AML) is characterized by an increased risk of myeloid neoplasms, lymphoid neoplasms, adult-onset single- or multiple-lineage cytopenias (including aplastic anemia), and red blood cell macrocytosis. The most common myeloid neoplasms include MDS, AML, and therapy-related myeloid neoplasms. Chronic myelomonocytic leukemia, chronic myeloid leukemia, and myeloproliferative neoplasms are less common. Lymphoid neoplasms include non-Hodgkin lymphoma, Hodgkin lymphoma, multiple myeloma, chronic lymphocytic leukemia, and acute lymphoblastic leukemia.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/895780">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_896239"><div><strong>14q32 duplication syndrome</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>896239</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C4225449</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">A rare chromosomal anomaly syndrome resulting from the partial duplication of the long arm of chromosome 14 that results in a predisposition to a number of adult-onset myeloproliferative neoplasms, including acute myeloid leukaemia, chronic myelomonocytic leukaemia and myeloproliferative neoplasms especially essential thrombocythemia. Progression to myelofibrosis and secondary acute myeloid leukaemia can be observed.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/896239">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_934711"><div><strong>Bone marrow failure syndrome 3</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>934711</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C4310744</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Bone marrow failure syndrome-3 is an autosomal recessive disorder characterized by onset of pancytopenia in early childhood. Patients may have additional variable nonspecific somatic abnormalities, including poor growth, microcephaly, and skin anomalies (summary by Tummala et al., 2016). BMFS3 has a distinct phenotype and may include features that overlap with Shwachman-Diamond syndrome (SDS1; 260400), such as pancreatic insufficiency and short stature, and with dyskeratosis congenita (see, e.g., DKCA1, 127550), such as dental and hair abnormalities and shortened telomeres. In addition, some patients may have joint and skeletal abnormalities, impaired development, and retinal dysplasia (summary by D'Amours et al., 2018). For a discussion of genetic heterogeneity of BMFS, see BMFS1 (614675).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/934711">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_1640046"><div><strong>Shwachman-Diamond syndrome 1</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1640046</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C4692625</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Shwachman-Diamond syndrome (SDS) is characterized by exocrine pancreatic dysfunction with malabsorption, malnutrition, and growth failure; hematologic abnormalities with single- or multilineage cytopenias and susceptibility to myelodysplastic syndrome (MDS) and acute myelogenous leukemia (AML); and bone abnormalities. In almost all affected children, persistent or intermittent neutropenia is an early finding. Short stature and recurrent infections are common.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1640046">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_1762901"><div><strong>Monosomy 7 myelodysplasia and leukemia syndrome 2</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1762901</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C5436668</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Monosomy 7 myelodysplasia and leukemia syndrome-2 (M7MLS2) is an autosomal dominant hematologic disorder characterized by onset of pancytopenia, acute myelogenous leukemia (AML), and variable features of myelodysplastic syndrome (MDS) usually in the first decades of life. Bone marrow cells show monosomy 7. Germline mutations in the SAMD9 gene, located on chromosome 7q, have a gain-of-function suppressive effect on the cell cycle, resulting in decreased cellular proliferation. It is hypothesized that this germline defect leads to selective pressure favoring somatic loss of the chromosome 7 harboring the mutant allele (adaptation by aneuploidy) (summary by Wong et al., 2018). For a discussion of genetic heterogeneity of monosomy 7 myelodysplasia and leukemia syndrome, see 252270.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1762901">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_1754257"><div><strong>AMED syndrome, digenic</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1754257</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C5436906</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">AMED syndrome (AMEDS) is an autosomal recessive digenic multisystem disorder characterized by global developmental delay with impaired intellectual development, onset of bone marrow failure and myelodysplastic syndrome (MDS) in childhood, and poor overall growth with short stature (summary by Oka et al., 2020). For a discussion of genetic heterogeneity of bone marrow failure syndrome (BMFS), see BMFS1 (614675).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1754257">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_1790819"><div><strong>Erythroleukemia, familial, susceptibility to</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1790819</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C5552985</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Finding</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Familial erythroleukemia (FERLK) is a leukemic or preleukemic state in which red cell proliferation is the predominant feature. Hematologic characteristics include particularly ineffective and hyperplastic erythropoiesis with megaloblastic components accompanied by myeloblastic proliferation of varying degree (Park et al., 2002). Park et al. (2002) discussed the evolution of the definition of 'erythroleukemia,' which is considered by most to be a subtype of acute myelogenous leukemia (AML; 601626). Controversy about the precise definition of erythroleukemia revolves around the number or percentage of erythroblasts and myeloblasts found in the bone marrow and peripheral circulation. In the French-American-British (FAB) classification system (Bennett et al., 1985), it is known as AML-M6, whereas in the revised World Health Organization (WHO) classification system (Harris et al., 1999), it is known as 'AML, not otherwise categorized' (Zini and D'Onofrio, 2004).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1790819">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_1823959"><div><strong>Tumor predisposition syndrome 2</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1823959</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C5774186</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Tumor predisposition syndrome-2 (TPDS2) is an autosomal recessive cancer predisposition syndrome characterized by the onset of various types of tumors or malignancies in young adulthood. The most common clinical manifestations include acute myeloid leukemia (AML), myelodysplastic syndrome, colorectal adenomatous polyposis and carcinoma, and uveal melanoma, although other tumors and malignancies have been reported (summary by Palles et al., 2022). For a discussion of genetic heterogeneity of TPDS, see TPDS1 (614327).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1823959">Condition Record</a></div></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_896239" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">14q32 duplication syndrome</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_9730" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Acute myeloid leukemia</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1754257" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">AMED syndrome, digenic</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_934711" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Bone marrow failure syndrome 3</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_895780" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">DDX41-related hematologic malignancy predisposition syndrome</a></div><div class="jig-moreless" data-jigconfig="class: 'moveDown', moreText: 'See full list (20)', lessText: 'Show less', nodeBefore: 0"><span id="clinMore">
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_481294" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Deafness-lymphedema-leukemia syndrome</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_346548" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Dohle bodies and leukemia</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_216941" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Dyskeratosis congenita, X-linked</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1790819" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Erythroleukemia, familial, susceptibility to</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_325420" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Fanconi anemia complementation group D1</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_372133" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Fanconi anemia complementation group N</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_896157" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Fanconi anemia complementation group T</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_442777" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Glioma susceptibility 3</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_321945" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Hereditary thrombocytopenia and hematological cancer predisposition syndrome associated with RUNX1</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_383699" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Leukemia, acute myelocytic, with polyposis coli and colon cancer</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_381529" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Monosomy 7 myelodysplasia and leukemia syndrome 1</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1762901" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Monosomy 7 myelodysplasia and leukemia syndrome 2</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_375050" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Nonimmune chronic idiopathic neutropenia of adults</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1640046" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Shwachman-Diamond syndrome 1</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1823959" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Tumor predisposition syndrome 2</a></div></span></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_105">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Professional_guidelines">Professional guidelines</h1><a sid="105" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">PubMed<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpPM"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/38269572">Essential thrombocythemia: 2024 update on diagnosis, risk stratification, and management.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Tefferi A,
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||
Vannucchi AM,
|
||
Barbui T</span><br />
|
||
<span class="medgenPMjournal">Am J Hematol</span>
|
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2024 Apr;99(4):697-718.
|
||
Epub 2024 Jan 25
|
||
doi: 10.1002/ajh.27216.
|
||
<span class="bold">PMID: </span><a href="/pubmed/38269572" target="_blank">38269572</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/37357958">Polycythemia vera: 2024 update on diagnosis, risk-stratification, and management.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Tefferi A,
|
||
Barbui T</span><br />
|
||
<span class="medgenPMjournal">Am J Hematol</span>
|
||
2023 Sep;98(9):1465-1487.
|
||
Epub 2023 Jun 26
|
||
doi: 10.1002/ajh.27002.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37357958" target="_blank">37357958</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/36594187">Acute myeloid leukemia: 2023 update on diagnosis, risk-stratification, and management.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Shimony S,
|
||
Stahl M,
|
||
Stone RM</span><br />
|
||
<span class="medgenPMjournal">Am J Hematol</span>
|
||
2023 Mar;98(3):502-526.
|
||
Epub 2023 Jan 13
|
||
doi: 10.1002/ajh.26822.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36594187" target="_blank">36594187</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(%22acute%20myeloid%20leukemia%22%5Btiab%3A~0%5D)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">See all (2041)</a></div><h3 class="subhead">Curated<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpCurated"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/22138009">NCCN Task Force report: Evaluating the clinical utility of tumor markers in oncology.</a></div>
|
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<div class="portlet_content ln"><span class="medgenPMauthor">Febbo PG,
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||
Ladanyi M,
|
||
Aldape KD,
|
||
De Marzo AM,
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||
Hammond ME,
|
||
Hayes DF,
|
||
Iafrate AJ,
|
||
Kelley RK,
|
||
Marcucci G,
|
||
Ogino S,
|
||
Pao W,
|
||
Sgroi DC,
|
||
Birkeland ML</span><br />
|
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<span class="medgenPMjournal">J Natl Compr Canc Netw</span>
|
||
2011 Nov;9 Suppl 5:S1-32; quiz S33.
|
||
doi: 10.6004/jnccn.2011.0137.
|
||
<span class="bold">PMID: </span><a href="/pubmed/22138009" target="_blank">22138009</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=" title="PubMed search"></a></div><h3 class="nl vspace"><a href="https://www.nccn.org/professionals/physician_gls/pdf/all.pdf" target="_blank">NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) Acute Lymphoblastic Leukemia, 2024</a></h3>
|
||
<h3 class="nl vspace"><a href="https://www.nccn.org/professionals/physician_gls/pdf/aml.pdf" target="_blank">NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) Acute Myeloid Leukemia, 2023</a></h3>
|
||
</div>
|
||
</div>
|
||
<div class="display-none help-popup" id="guidelinesHelpPM">These guidelines are articles in PubMed that match specific search criteria developed by MedGen to capture the most relevant practice guidelines. This list may not be comprehensive and may include broader topics as well. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div><div class="display-none help-popup" id="guidelinesHelpCurated">These guidelines are manually curated by the MedGen team
|
||
to supplement articles available in PubMed. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div>
|
||
<div class="portlet mgSection" id="ID_103">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_clinical_studies">Recent clinical studies</h1><a sid="103" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">Etiology</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/36722402">The clinical impact of the molecular landscape of acute myeloid leukemia.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Kayser S,
|
||
Levis MJ</span><br />
|
||
<span class="medgenPMjournal">Haematologica</span>
|
||
2023 Feb 1;108(2):308-320.
|
||
doi: 10.3324/haematol.2022.280801.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36722402" target="_blank">36722402</a><a href="/pmc/articles/PMC9890016" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/36135060">Management of Acute Myeloid Leukemia: A Review for General Practitioners in Oncology.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Stubbins RJ,
|
||
Francis A,
|
||
Kuchenbauer F,
|
||
Sanford D</span><br />
|
||
<span class="medgenPMjournal">Curr Oncol</span>
|
||
2022 Aug 30;29(9):6245-6259.
|
||
doi: 10.3390/curroncol29090491.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36135060" target="_blank">36135060</a><a href="/pmc/articles/PMC9498246" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/35050458">Acute Myeloid Leukemia Stem Cells: Origin, Characteristics, and Clinical Implications.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Long NA,
|
||
Golla U,
|
||
Sharma A,
|
||
Claxton DF</span><br />
|
||
<span class="medgenPMjournal">Stem Cell Rev Rep</span>
|
||
2022 Apr;18(4):1211-1226.
|
||
Epub 2022 Jan 20
|
||
doi: 10.1007/s12015-021-10308-6.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35050458" target="_blank">35050458</a><a href="/pmc/articles/PMC10942736" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/27367478">'Acute myeloid leukemia: a comprehensive review and 2016 update'.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">De Kouchkovsky I,
|
||
Abdul-Hay M</span><br />
|
||
<span class="medgenPMjournal">Blood Cancer J</span>
|
||
2016 Jul 1;6(7):e441.
|
||
doi: 10.1038/bcj.2016.50.
|
||
<span class="bold">PMID: </span><a href="/pubmed/27367478" target="_blank">27367478</a><a href="/pmc/articles/PMC5030376" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/20113895">Acute myeloid leukemia.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Rubnitz JE,
|
||
Gibson B,
|
||
Smith FO</span><br />
|
||
<span class="medgenPMjournal">Hematol Oncol Clin North Am</span>
|
||
2010 Feb;24(1):35-63.
|
||
doi: 10.1016/j.hoc.2009.11.008.
|
||
<span class="bold">PMID: </span><a href="/pubmed/20113895" target="_blank">20113895</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Acute%20myeloid%20leukemia%22%20AND%20Etiology%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (18154)</a></div><h3 class="subhead">Diagnosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/35101585">Diagnosis and treatment of therapy-related acute myeloid leukemia.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Strickland SA,
|
||
Vey N</span><br />
|
||
<span class="medgenPMjournal">Crit Rev Oncol Hematol</span>
|
||
2022 Mar;171:103607.
|
||
Epub 2022 Jan 31
|
||
doi: 10.1016/j.critrevonc.2022.103607.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35101585" target="_blank">35101585</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/32236160">Acute Myeloid Leukemia: A Review.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Pelcovits A,
|
||
Niroula R</span><br />
|
||
<span class="medgenPMjournal">R I Med J (2013)</span>
|
||
2020 Apr 1;103(3):38-40.
|
||
<span class="bold">PMID: </span><a href="/pubmed/32236160" target="_blank">32236160</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/31101526">Epidemiology of acute myeloid leukemia: Recent progress and enduring challenges.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Shallis RM,
|
||
Wang R,
|
||
Davidoff A,
|
||
Ma X,
|
||
Zeidan AM</span><br />
|
||
<span class="medgenPMjournal">Blood Rev</span>
|
||
2019 Jul;36:70-87.
|
||
Epub 2019 Apr 29
|
||
doi: 10.1016/j.blre.2019.04.005.
|
||
<span class="bold">PMID: </span><a href="/pubmed/31101526" target="_blank">31101526</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/27367478">'Acute myeloid leukemia: a comprehensive review and 2016 update'.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">De Kouchkovsky I,
|
||
Abdul-Hay M</span><br />
|
||
<span class="medgenPMjournal">Blood Cancer J</span>
|
||
2016 Jul 1;6(7):e441.
|
||
doi: 10.1038/bcj.2016.50.
|
||
<span class="bold">PMID: </span><a href="/pubmed/27367478" target="_blank">27367478</a><a href="/pmc/articles/PMC5030376" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/20113895">Acute myeloid leukemia.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Rubnitz JE,
|
||
Gibson B,
|
||
Smith FO</span><br />
|
||
<span class="medgenPMjournal">Hematol Oncol Clin North Am</span>
|
||
2010 Feb;24(1):35-63.
|
||
doi: 10.1016/j.hoc.2009.11.008.
|
||
<span class="bold">PMID: </span><a href="/pubmed/20113895" target="_blank">20113895</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Acute%20myeloid%20leukemia%22%20AND%20Diagnosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (17905)</a></div><h3 class="subhead">Therapy</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/36517123">Improving clinical trials in higher-risk myelodysplastic syndromes.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Sekeres MA</span><br />
|
||
<span class="medgenPMjournal">Best Pract Res Clin Haematol</span>
|
||
2022 Dec;35(4):101406.
|
||
Epub 2022 Oct 28
|
||
doi: 10.1016/j.beha.2022.101406.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36517123" target="_blank">36517123</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/35852098">Design of the VIALE-M phase III trial of venetoclax and oral azacitidine maintenance therapy in acute myeloid leukemia.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Ivanov V,
|
||
Yeh SP,
|
||
Mayer J,
|
||
Saini L,
|
||
Unal A,
|
||
Boyiadzis M,
|
||
Hoffman DM,
|
||
Kang K,
|
||
Addo SN,
|
||
Mendes WL,
|
||
Fathi AT</span><br />
|
||
<span class="medgenPMjournal">Future Oncol</span>
|
||
2022 Aug;18(26):2879-2889.
|
||
Epub 2022 Jul 19
|
||
doi: 10.2217/fon-2022-0450.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35852098" target="_blank">35852098</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/33434043">Immune Biology of Acute Myeloid Leukemia: Implications for Immunotherapy.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Khaldoyanidi S,
|
||
Nagorsen D,
|
||
Stein A,
|
||
Ossenkoppele G,
|
||
Subklewe M</span><br />
|
||
<span class="medgenPMjournal">J Clin Oncol</span>
|
||
2021 Feb 10;39(5):419-432.
|
||
Epub 2021 Jan 12
|
||
doi: 10.1200/JCO.20.00475.
|
||
<span class="bold">PMID: </span><a href="/pubmed/33434043" target="_blank">33434043</a><a href="/pmc/articles/PMC8078464" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/31547736">CPX-351 (vyxeos) in AML.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Alfayez M,
|
||
Kantarjian H,
|
||
Kadia T,
|
||
Ravandi-Kashani F,
|
||
Daver N</span><br />
|
||
<span class="medgenPMjournal">Leuk Lymphoma</span>
|
||
2020 Feb;61(2):288-297.
|
||
Epub 2019 Sep 24
|
||
doi: 10.1080/10428194.2019.1660970.
|
||
<span class="bold">PMID: </span><a href="/pubmed/31547736" target="_blank">31547736</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/27354720">Maintenance therapy in acute myeloid leukemia: an evidence-based review of randomized trials.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Rashidi A,
|
||
Walter RB,
|
||
Tallman MS,
|
||
Appelbaum FR,
|
||
DiPersio JF</span><br />
|
||
<span class="medgenPMjournal">Blood</span>
|
||
2016 Aug 11;128(6):763-73.
|
||
Epub 2016 Jun 27
|
||
doi: 10.1182/blood-2016-03-674127.
|
||
<span class="bold">PMID: </span><a href="/pubmed/27354720" target="_blank">27354720</a><a href="/pmc/articles/PMC4982451" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Acute%20myeloid%20leukemia%22%20AND%20Therapy%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (19347)</a></div><h3 class="subhead">Prognosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/32929488">Flotetuzumab as salvage immunotherapy for refractory acute myeloid leukemia.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Uy GL,
|
||
Aldoss I,
|
||
Foster MC,
|
||
Sayre PH,
|
||
Wieduwilt MJ,
|
||
Advani AS,
|
||
Godwin JE,
|
||
Arellano ML,
|
||
Sweet KL,
|
||
Emadi A,
|
||
Ravandi F,
|
||
Erba HP,
|
||
Byrne M,
|
||
Michaelis L,
|
||
Topp MS,
|
||
Vey N,
|
||
Ciceri F,
|
||
Carrabba MG,
|
||
Paolini S,
|
||
Huls GA,
|
||
Jongen-Lavrencic M,
|
||
Wermke M,
|
||
Chevallier P,
|
||
Gyan E,
|
||
Récher C,
|
||
Stiff PJ,
|
||
Pettit KM,
|
||
Löwenberg B,
|
||
Church SE,
|
||
Anderson E,
|
||
Vadakekolathu J,
|
||
Santaguida M,
|
||
Rettig MP,
|
||
Muth J,
|
||
Curtis T,
|
||
Fehr E,
|
||
Guo K,
|
||
Zhao J,
|
||
Bakkacha O,
|
||
Jacobs K,
|
||
Tran K,
|
||
Kaminker P,
|
||
Kostova M,
|
||
Bonvini E,
|
||
Walter RB,
|
||
Davidson-Moncada JK,
|
||
Rutella S,
|
||
DiPersio JF</span><br />
|
||
<span class="medgenPMjournal">Blood</span>
|
||
2021 Feb 11;137(6):751-762.
|
||
doi: 10.1182/blood.2020007732.
|
||
<span class="bold">PMID: </span><a href="/pubmed/32929488" target="_blank">32929488</a><a href="/pmc/articles/PMC7885824" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/30361262">Venetoclax combined with decitabine or azacitidine in treatment-naive, elderly patients with acute myeloid leukemia.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">DiNardo CD,
|
||
Pratz K,
|
||
Pullarkat V,
|
||
Jonas BA,
|
||
Arellano M,
|
||
Becker PS,
|
||
Frankfurt O,
|
||
Konopleva M,
|
||
Wei AH,
|
||
Kantarjian HM,
|
||
Xu T,
|
||
Hong WJ,
|
||
Chyla B,
|
||
Potluri J,
|
||
Pollyea DA,
|
||
Letai A</span><br />
|
||
<span class="medgenPMjournal">Blood</span>
|
||
2019 Jan 3;133(1):7-17.
|
||
Epub 2018 Oct 25
|
||
doi: 10.1182/blood-2018-08-868752.
|
||
<span class="bold">PMID: </span><a href="/pubmed/30361262" target="_blank">30361262</a><a href="/pmc/articles/PMC6318429" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/29107678">Carcinogenicity of benzene.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Loomis D,
|
||
Guyton KZ,
|
||
Grosse Y,
|
||
El Ghissassi F,
|
||
Bouvard V,
|
||
Benbrahim-Tallaa L,
|
||
Guha N,
|
||
Vilahur N,
|
||
Mattock H,
|
||
Straif K;
|
||
International Agency for Research on Cancer Monograph Working Group</span><br />
|
||
<span class="medgenPMjournal">Lancet Oncol</span>
|
||
2017 Dec;18(12):1574-1575.
|
||
Epub 2017 Oct 26
|
||
doi: 10.1016/S1470-2045(17)30832-X.
|
||
<span class="bold">PMID: </span><a href="/pubmed/29107678" target="_blank">29107678</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/17019734">Acute myeloid leukemia: epidemiology and etiology.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Deschler B,
|
||
Lübbert M</span><br />
|
||
<span class="medgenPMjournal">Cancer</span>
|
||
2006 Nov 1;107(9):2099-107.
|
||
doi: 10.1002/cncr.22233.
|
||
<span class="bold">PMID: </span><a href="/pubmed/17019734" target="_blank">17019734</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/16319675">Neutropenic enterocolitis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Davila ML</span><br />
|
||
<span class="medgenPMjournal">Curr Opin Gastroenterol</span>
|
||
2006 Jan;22(1):44-7.
|
||
doi: 10.1097/01.mog.0000198073.14169.3b.
|
||
<span class="bold">PMID: </span><a href="/pubmed/16319675" target="_blank">16319675</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Acute%20myeloid%20leukemia%22%20AND%20Prognosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (17915)</a></div><h3 class="subhead">Clinical prediction guides</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/36517128">How can we incorporate molecular data into the IPSS?</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Bejar R</span><br />
|
||
<span class="medgenPMjournal">Best Pract Res Clin Haematol</span>
|
||
2022 Dec;35(4):101410.
|
||
Epub 2022 Nov 1
|
||
doi: 10.1016/j.beha.2022.101410.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36517128" target="_blank">36517128</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/34135913">Prognosis and Characterization of Immune Microenvironment in Acute Myeloid Leukemia Through Identification of an Autophagy-Related Signature.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Fu D,
|
||
Zhang B,
|
||
Wu S,
|
||
Zhang Y,
|
||
Xie J,
|
||
Ning W,
|
||
Jiang H</span><br />
|
||
<span class="medgenPMjournal">Front Immunol</span>
|
||
2021;12:695865.
|
||
Epub 2021 May 31
|
||
doi: 10.3389/fimmu.2021.695865.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34135913" target="_blank">34135913</a><a href="/pmc/articles/PMC8200670" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/32744763">Myelodysplastic syndromes: 2021 update on diagnosis, risk stratification and management.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Garcia-Manero G,
|
||
Chien KS,
|
||
Montalban-Bravo G</span><br />
|
||
<span class="medgenPMjournal">Am J Hematol</span>
|
||
2020 Nov;95(11):1399-1420.
|
||
doi: 10.1002/ajh.25950.
|
||
<span class="bold">PMID: </span><a href="/pubmed/32744763" target="_blank">32744763</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/28612456">Day 14 bone marrow examination in the management of acute myeloid leukemia.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Terry CM,
|
||
Shallis RM,
|
||
Estey E,
|
||
Lim SH</span><br />
|
||
<span class="medgenPMjournal">Am J Hematol</span>
|
||
2017 Oct;92(10):1079-1084.
|
||
Epub 2017 Jul 19
|
||
doi: 10.1002/ajh.24818.
|
||
<span class="bold">PMID: </span><a href="/pubmed/28612456" target="_blank">28612456</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/10521349">Molecular classification of cancer: class discovery and class prediction by gene expression monitoring.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Golub TR,
|
||
Slonim DK,
|
||
Tamayo P,
|
||
Huard C,
|
||
Gaasenbeek M,
|
||
Mesirov JP,
|
||
Coller H,
|
||
Loh ML,
|
||
Downing JR,
|
||
Caligiuri MA,
|
||
Bloomfield CD,
|
||
Lander ES</span><br />
|
||
<span class="medgenPMjournal">Science</span>
|
||
1999 Oct 15;286(5439):531-7.
|
||
doi: 10.1126/science.286.5439.531.
|
||
<span class="bold">PMID: </span><a href="/pubmed/10521349" target="_blank">10521349</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Acute%20myeloid%20leukemia%22%20AND%20Clinical%20prediction%20guides%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (13046)</a></div></div>
|
||
</div>
|
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|
||
<div class="portlet mgSection" id="ID_104">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_systematic_reviews">Recent systematic reviews</h1><a sid="104" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln">
|
||
<div class="nl"><a target="_blank" href="/pubmed/37686807">Early Life Nutrition Factors and Risk of Acute Leukemia in Children: Systematic Review and Meta-Analysis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Kintossou AK,
|
||
Blanco-Lopez J,
|
||
Iguacel I,
|
||
Pisanu S,
|
||
Almeida CCB,
|
||
Steliarova-Foucher E,
|
||
Sierens C,
|
||
Gunter MJ,
|
||
Ladas EJ,
|
||
Barr RD,
|
||
Van Herck K,
|
||
Kozlakidis Z,
|
||
Huybrechts I</span><br />
|
||
<span class="medgenPMjournal">Nutrients</span>
|
||
2023 Aug 29;15(17)
|
||
doi: 10.3390/nu15173775.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37686807" target="_blank">37686807</a><a href="/pmc/articles/PMC10489830" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/37170899">Therapies for acute myeloid leukemia in patients ineligible for standard induction chemotherapy: a systematic review.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Heuser M,
|
||
Fernandez C,
|
||
Hauch O,
|
||
Klibanov OM,
|
||
Chaudhary T,
|
||
Rives V</span><br />
|
||
<span class="medgenPMjournal">Future Oncol</span>
|
||
2023 Apr;19(11):789-810.
|
||
Epub 2023 May 12
|
||
doi: 10.2217/fon-2022-1286.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37170899" target="_blank">37170899</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/35483397">Antifungal prophylaxis in adult patients with acute myeloid leukaemia treated with novel targeted therapies: a systematic review and expert consensus recommendation from the European Hematology Association.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Stemler J,
|
||
de Jonge N,
|
||
Skoetz N,
|
||
Sinkó J,
|
||
Brüggemann RJ,
|
||
Busca A,
|
||
Ben-Ami R,
|
||
Ráčil Z,
|
||
Piechotta V,
|
||
Lewis R,
|
||
Cornely OA</span><br />
|
||
<span class="medgenPMjournal">Lancet Haematol</span>
|
||
2022 May;9(5):e361-e373.
|
||
doi: 10.1016/S2352-3026(22)00073-4.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35483397" target="_blank">35483397</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/33030517">Association of Measurable Residual Disease With Survival Outcomes in Patients With Acute Myeloid Leukemia: A Systematic Review and Meta-analysis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Short NJ,
|
||
Zhou S,
|
||
Fu C,
|
||
Berry DA,
|
||
Walter RB,
|
||
Freeman SD,
|
||
Hourigan CS,
|
||
Huang X,
|
||
Nogueras Gonzalez G,
|
||
Hwang H,
|
||
Qi X,
|
||
Kantarjian H,
|
||
Ravandi F</span><br />
|
||
<span class="medgenPMjournal">JAMA Oncol</span>
|
||
2020 Dec 1;6(12):1890-1899.
|
||
doi: 10.1001/jamaoncol.2020.4600.
|
||
<span class="bold">PMID: </span><a href="/pubmed/33030517" target="_blank">33030517</a><a href="/pmc/articles/PMC7545346" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/26169616">Recommendations for the Use of WBC Growth Factors: American Society of Clinical Oncology Clinical Practice Guideline Update.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Smith TJ,
|
||
Bohlke K,
|
||
Lyman GH,
|
||
Carson KR,
|
||
Crawford J,
|
||
Cross SJ,
|
||
Goldberg JM,
|
||
Khatcheressian JL,
|
||
Leighl NB,
|
||
Perkins CL,
|
||
Somlo G,
|
||
Wade JL,
|
||
Wozniak AJ,
|
||
Armitage JO;
|
||
American Society of Clinical Oncology</span><br />
|
||
<span class="medgenPMjournal">J Clin Oncol</span>
|
||
2015 Oct 1;33(28):3199-212.
|
||
Epub 2015 Jul 13
|
||
doi: 10.1200/JCO.2015.62.3488.
|
||
<span class="bold">PMID: </span><a href="/pubmed/26169616" target="_blank">26169616</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Acute%20myeloid%20leukemia%22%20AND%20systematic%5Bsb%5D%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (271)</a></div></div>
|
||
</div>
|
||
</div></div></div></div></div></div></div>
|
||
<div id="messagearea_bottom">
|
||
|
||
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|
||
<div class=" bottom">
|
||
|
||
</div>
|
||
|
||
</div>
|
||
</div>
|
||
<div class="supplemental col three_col last">
|
||
<h2 class="offscreen_noflow">Supplemental Content</h2>
|
||
|
||
<div>
|
||
|
||
<!-- MedGen supplemental column starts here -->
|
||
<div class="rightCol mgCol">
|
||
<div class="portlet mgSection" id="ID_113">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Table_of_contents">Table of contents</h1><a sid="113" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="portlet_content ln"><ul id="my-toc"></ul></div>
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|
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|
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<div class="portlet mgSection" id="ID_106">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Genetic_Testing_Registry">Genetic Testing Registry</h1><a sid="106" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><ul><li><a href="/gtr/tests?term=C0023467%5bDISCUI%5d&filter=method%3A2%5F8" target="_blank">Deletion/duplication analysis (98)</a></li>
|
||
<li><a href="/gtr/tests?term=C0023467%5bDISCUI%5d&filter=method%3A2%5F29" target="_blank">Detection of homozygosity (2)</a></li>
|
||
<li><a href="/gtr/tests?term=C0023467%5bDISCUI%5d&filter=method%3A3%5F23" target="_blank">FISH-interphase (22)</a></li>
|
||
<li><a href="/gtr/tests?term=C0023467%5bDISCUI%5d&filter=method%3A3%5F31" target="_blank">Fluorescence in situ hybridization (FISH) (9)</a></li>
|
||
<li><a href="/gtr/tests?term=C0023467%5bDISCUI%5d&filter=method%3A3%5F32" target="_blank">Karyotyping (4)</a></li>
|
||
<li><a href="/gtr/tests?term=C0023467%5bDISCUI%5d&filter=method%3A2%5F12" target="_blank">Microsatellite instability testing (MSI) (1)</a></li>
|
||
<li><a href="/gtr/tests?term=C0023467%5bDISCUI%5d&filter=method%3A2%5F18" target="_blank">Mutation scanning of select exons (7)</a></li>
|
||
<li><a href="/gtr/tests?term=C0023467%5bDISCUI%5d&test_type=Research" target="_blank">Research (1)</a></li>
|
||
<li><a href="/gtr/tests?term=C0023467%5bDISCUI%5d&filter=method%3A2%5F30" target="_blank">RNA analysis (16)</a></li>
|
||
<li><a href="/gtr/tests?term=C0023467%5bDISCUI%5d&filter=method%3A2%5F9" target="_blank">Sequence analysis of select exons (31)</a></li>
|
||
<li><a href="/gtr/tests?term=C0023467%5bDISCUI%5d&filter=method%3A2%5F7" target="_blank">Sequence analysis of the entire coding region (131)</a></li>
|
||
<li><a href="/gtr/tests?term=C0023467%5bDISCUI%5d&filter=method%3A2%5F19" target="_blank">Targeted variant analysis (91)</a></li>
|
||
<li><a href="/gtr/tests?term=C0023467%5bDISCUI%5d&filter=method%3A2%5F20" target="_blank">Uniparental disomy study (UPD) (1)</a></li>
|
||
<li class="portletSeeAll portletSeeAllPad"><total><a href="/gtr/tests?term=C0023467%5bDISCUI%5d" target="_blank">See all (315)</a></total></li>
|
||
</ul></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_119">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Clinical_resources">Clinical resources</h1><a sid="119" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="portlet_content ln"><ul><li><a href="https://www.omim.org/search?index=entry&start=1&limit=10&sort=score%20desc&field=number&search=601626" target="_blank">OMIM</a></li><li><a href="http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Expert=519" target="_blank">Orphanet</a></li><li><a href="https://clinicaltrials.gov/search?cond=Acute%20myeloid%20leukemia" target="_blank">ClinicalTrials.gov</a></li></ul></div>
|
||
</div>
|
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|
||
<div class="portlet mgSection" id="ID_121">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Practice_guidelines">Practice guidelines</h1><a sid="121" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><ul class="a_poppers"><li><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(%22acute%20myeloid%20leukemia%22%5Btiab%3A~0%5D)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">PubMed</a><div class="help-popup">See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div></li><li><a target="_blank" href="/books/?term=((%22clinical%20guidelines%22%5BResource%20Type%5D)%20OR%20%22practice%20guideline%22%5BPublication%20Type%5D)%20AND%20(%22Acute%20myeloid%20leukemia%22)">Bookshelf</a><div class="help-popup">See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div></li></ul><h3 class="subhead">Curated</h3><ul class="a_poppers"><li><a target="_blank" href="https://www.nccn.org/professionals/physician_gls/pdf/all.pdf">NCCN, 2024</a><div>NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) Acute Lymphoblastic Leukemia, 2024</div></li><li><a target="_blank" href="https://www.nccn.org/professionals/physician_gls/pdf/aml.pdf">NCCN, 2023</a><div>NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) Acute Myeloid Leukemia, 2023</div></li><li><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov//22138009/">NCCN, 2011</a><div>NCCN Task Force report: Evaluating the clinical utility of tumor markers in oncology.</div></li></ul></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_115">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Molecular_resources">Molecular resources</h1><a sid="115" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><ul><li><a href="http://www.omim.org/search?index=entry&start=1&limit=10&sort=score%20desc&field=number&search=114350%20116897%20136351%20137295%20147796%20151385%20164040%20164920%20187270%20190070%20600618%20600700%20601768%20602409%20602769%20603025%20604332" target="_blank">OMIM</a></li><li><a href="/clinvar/?term=861[geneid]" target="_blank">View RUNX1 variations in ClinVar</a></li><li><a href="/clinvar/?term=1050[geneid]" target="_blank">View CEBPA variations in ClinVar</a></li><li><a href="/clinvar/?term=1788[geneid]" target="_blank">View DNMT3A variations in ClinVar</a></li><li><a href="/clinvar/?term=2120[geneid]" target="_blank">View ETV6 variations in ClinVar</a></li><li><a href="/clinvar/?term=2322[geneid]" target="_blank">View FLT3 variations in ClinVar</a></li><li><a href="/clinvar/?term=2624[geneid]" target="_blank">View GATA2 variations in ClinVar</a></li><li><a href="/clinvar/?term=3717[geneid]" target="_blank">View JAK2 variations in ClinVar</a></li><li><a href="/clinvar/?term=3815[geneid]" target="_blank">View KIT variations in ClinVar</a></li><li><a href="/clinvar/?term=3845[geneid]" target="_blank">View KRAS variations in ClinVar</a></li><li><a href="/clinvar/?term=4026[geneid]" target="_blank">View LPP variations in ClinVar</a></li><li><a href="/clinvar/?term=4869[geneid]" target="_blank">View NPM1 variations in ClinVar</a></li><li><a href="/clinvar/?term=6455[geneid]" target="_blank">View SH3GL1 variations in ClinVar</a></li><li><a href="/clinvar/?term=7015[geneid]" target="_blank">View TERT variations in ClinVar</a></li><li><a href="/clinvar/?term=8021[geneid]" target="_blank">View NUP214 variations in ClinVar</a></li><li><a href="/clinvar/?term=8028[geneid]" target="_blank">View MLLT10 variations in ClinVar</a></li><li><a href="/clinvar/?term=8301[geneid]" target="_blank">View PICALM variations in ClinVar</a></li><li><a href="/clinvar/?term=26511[geneid]" target="_blank">View CHIC2 variations in ClinVar</a></li><li><a href="/nuccore/160358346,170014706,176866166,219801765,224451097,224586926,224809238,237649061,269954735,293336035,300796208,308522741,319655733,332634979,333360883" target="_blank">RefSeqGene</a></li><li><a href="https://catalog.coriell.org/Search?q=601626" target="_blank">Coriell Institute for Medical Research</a></li></ul></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_116">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Consumer_resources">Consumer resources</h1><a sid="116" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><ul><li><a href="http://www.diseaseinfosearch.org/Acute+Myelocytic+Leukemia/203" target="_blank">Genetic Alliance</a></li><li><a href="http://www.diseaseinfosearch.org/Acute+Myeloid+Leukemia%2C+Adult/204" target="_blank">Genetic Alliance</a></li><li><a href="https://www.malacards.org/card/leukemia_acute_myeloid" target="_blank">MalaCards</a></li><li><a href="https://vsearch.nlm.nih.gov/vivisimo/cgi-bin/query-meta?v:project=medlineplus&query=Acute%20myeloid%20leukemia" target="_blank">MedlinePlus</a></li><li><a href="#" class="jig-ncbipopper results_settings" role="button" aria-expanded="false" aria-haspopup="true" data-jigconfig="triggerPosition : 'bottom center',destPosition : 'top center', hasArrow : false,openEvent : 'click',closeEvent : 'click',isTriggerElementCloseClick: false, addCloseButton : false, groupName: 'entrez_pg',destSelector : '#ghrPopup'">MedlinePlusGenetics (GHR)<span class="tgt_dark"></span></a></li><li><a href="https://rarediseases.info.nih.gov/diseases/12757/disease" target="_blank">NCATS Office of Rare Diseases Research (GARD)</a></li></ul><div id="ghrPopup" aria-live="assertive" aria-hidden="true" style="display: none;" class="portlet_popup tabPopper ui-helper-reset ui-ncbipopper-wrapper ui-ncbipopper-basic"><ul class="column_list"><li><a target="_blank" href="https://medlineplus.gov/genetics/condition/core-binding-factor-acute-myeloid-leukemia">Core binding factor acute myeloid leukemia</a></li><li><a target="_blank" href="https://medlineplus.gov/genetics/condition/cytogenetically-normal-acute-myeloid-leukemia">Cytogenetically normal acute myeloid leukemia</a></li><li><a target="_blank" href="https://medlineplus.gov/genetics/condition/familial-acute-myeloid-leukemia-with-mutated-cebpa">Familial acute myeloid leukemia with mutated cebpa</a></li></ul></div></div>
|
||
</div>
|
||
</div>
|
||
<div class="portlet brieflink">
|
||
<div class="portlet_head">
|
||
<div class="portlet_title">
|
||
<h3>Reviews</h3>
|
||
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<div class="portlet_content">
|
||
<ul>
|
||
<li>
|
||
<a href="/pubmed/20963938" ref="ncbi_uid=&discoId=gtr_reviews&linkpos=1&linkpostotal=6" target="_blank"><span class="gene_reviews">GeneReviews</span></a>
|
||
</li>
|
||
<li>
|
||
<a href="/pubmed/33661592" ref="ncbi_uid=&discoId=gtr_reviews&linkpos=2&linkpostotal=6" target="_blank"><span class="gene_reviews">GeneReviews</span></a>
|
||
</li>
|
||
<li>
|
||
<a href="/pubmed/33226740" ref="ncbi_uid=&discoId=gtr_reviews&linkpos=3&linkpostotal=6" target="_blank"><span class="gene_reviews">GeneReviews</span></a>
|
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|
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<li>
|
||
<a href="/pubmed/34723452" ref="ncbi_uid=&discoId=gtr_reviews&linkpos=4&linkpostotal=6" target="_blank"><span class="gene_reviews">GeneReviews</span></a>
|
||
</li>
|
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<li>
|
||
<a href="/pubmed/clinical?term=Acute%20myeloid%20leukemia" ref="ncbi_uid=&discoId=gtr_reviews&linkpos=5&linkpostotal=6" target="_blank">PubMed Clinical Queries</a>
|
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<li>
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<a href="/pubmed?term=Acute%20myeloid%20leukemia%20AND%20humans[mesh]%20AND%20review[publication%20type]" ref="ncbi_uid=&discoId=gtr_reviews&linkpos=6&linkpostotal=6" target="_blank">Reviews in PubMed</a>
|
||
</li>
|
||
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|
||
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|
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|
||
|
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<!-- MedGen supplemental column ends here -->
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<h3>Related information</h3>
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<div class="portlet_content DiscoveryDbLinks">
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<ul>
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<li class="brieflinkpopper">
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<a class="brieflinkpopperctrl" href="/clinvar?LinkName=medgen_clinvar&from_uid=9730" ref="log$=recordlinks">ClinVar</a>
|
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<div class="brieflinkpop offscreen_noflow">Related medical variations</div>
|
||
</li>
|
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<a class="brieflinkpopperctrl" href="/gene?LinkName=medgen_gene_diseases&from_uid=9730" ref="log$=recordlinks">Gene</a>
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<div class="brieflinkpop offscreen_noflow">Related information in NCBI Gene</div>
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</li>
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<li class="brieflinkpopper">
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<a class="brieflinkpopperctrl" href="/gtr/tests?term=C0023467[DISCUI]" ref="log$=recordlinks">GTR</a>
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<div class="brieflinkpop offscreen_noflow">Related information in GTR</div>
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<a class="brieflinkpopperctrl" href="/gtr/tests?term=C0023467[DISCUI]&test_type=Clinical" ref="log$=recordlinks">GTR(Clinical)</a>
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<div class="brieflinkpop offscreen_noflow">Clinical tests in GTR</div>
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<a class="brieflinkpopperctrl" href="/gtr/tests?term=C0023467[DISCUI]&test_type=Research" ref="log$=recordlinks">GTR(Research)</a>
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<div class="brieflinkpop offscreen_noflow">Research tests in GTR</div>
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<a class="brieflinkpopperctrl" href="/mesh?LinkName=medgen_mesh&from_uid=9730" ref="log$=recordlinks">MeSH</a>
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<a class="brieflinkpopperctrl" href="/books?LinkName=medgen_books&from_uid=9730" ref="log$=recordlinks">NCBI Bookshelf</a>
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<div class="brieflinkpop offscreen_noflow">Related information in NCBI Bookshelf</div>
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<div class="brieflinkpop offscreen_noflow">Related records in OMIM</div>
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<a class="brieflinkpopperctrl" href="/pmc?LinkName=medgen_pmc&from_uid=9730" ref="log$=recordlinks">PMC Articles</a>
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<a class="brieflinkpopperctrl" href="/pubmed?LinkName=medgen_pubmed&from_uid=9730" ref="log$=recordlinks">PubMed</a>
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<a class="brieflinkpopperctrl" href="/pubmed?LinkName=medgen_pubmed_bookshelf_cited&from_uid=9730" ref="log$=recordlinks">PubMed (Bookshelf cited)</a>
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<div class="brieflinkpop offscreen_noflow">Links to PubMed based on citations in GeneReviews and Medical Genetics Summaries</div>
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<li class="brieflinkpopper">
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<a class="brieflinkpopperctrl" href="/pubmed?LinkName=medgen_pubmed_genereviews&from_uid=9730" ref="log$=recordlinks">PubMed (GeneReviews)</a>
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<div class="brieflinkpop offscreen_noflow">GeneReviews in PubMed</div>
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<li class="brieflinkpopper">
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<a class="brieflinkpopperctrl" href="/pubmed?LinkName=medgen_pubmed_omim&from_uid=9730" ref="log$=recordlinks">PubMed (OMIM)</a>
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<div class="brieflinkpop offscreen_noflow">Related literature resources in PubMed</div>
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Turn On
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<a class="htb ralinkpopperctrl" ref="log$=activity&linkpos=1" href="/portal/utils/pageresolver.fcgi?recordid=67d343cc2f30673f7bdcadff">Acute myeloid leukemia</a>
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<div class="ralinkpop offscreen_noflow">Acute myeloid leukemia<div class="brieflinkpopdesc"></div></div>
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<div class="tertiary">MedGen</div>
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<a class="htb ralinkpopperctrl" ref="log$=activity&linkpos=2" href="/portal/utils/pageresolver.fcgi?recordid=67d343c82f30673f7bdc8f53">SH3GL1 SH3 domain containing GRB2 like 1, endophilin A2 [Homo sapiens]</a>
|
||
<div class="ralinkpop offscreen_noflow">SH3GL1 SH3 domain containing GRB2 like 1, endophilin A2 [Homo sapiens]<div class="brieflinkpopdesc">Gene ID:6455</div></div>
|
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<div class="tertiary">Gene</div>
|
||
</li>
|
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<li class="ra_rcd ralinkpopper two_line">
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<a class="htb ralinkpopperctrl" ref="log$=activity&linkpos=3" href="/portal/utils/pageresolver.fcgi?recordid=67d343c62f30673f7bdc8284">PICALM phosphatidylinositol binding clathrin assembly protein [Homo sapiens]</a>
|
||
<div class="ralinkpop offscreen_noflow">PICALM phosphatidylinositol binding clathrin assembly protein [Homo sapiens]<div class="brieflinkpopdesc">Gene ID:8301</div></div>
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<div class="tertiary">Gene</div>
|
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</li>
|
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<li class="ra_rcd ralinkpopper two_line">
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<a class="htb ralinkpopperctrl" ref="log$=activity&linkpos=4" href="/portal/utils/pageresolver.fcgi?recordid=67d343c4cde49f3df7ba3bab">NUP214 nucleoporin 214 [Homo sapiens]</a>
|
||
<div class="ralinkpop offscreen_noflow">NUP214 nucleoporin 214 [Homo sapiens]<div class="brieflinkpopdesc">Gene ID:8021</div></div>
|
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<div class="tertiary">Gene</div>
|
||
</li>
|
||
<li class="ra_rcd ralinkpopper two_line">
|
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<a class="htb ralinkpopperctrl" ref="log$=activity&linkpos=5" href="/portal/utils/pageresolver.fcgi?recordid=67d343c2cde49f3df7ba2de6">MLLT10 MLLT10 histone lysine methyltransferase DOT1L cofactor [Homo sapiens]</a>
|
||
<div class="ralinkpop offscreen_noflow">MLLT10 MLLT10 histone lysine methyltransferase DOT1L cofactor [Homo sapiens]<div class="brieflinkpopdesc">Gene ID:8028</div></div>
|
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<div class="tertiary">Gene</div>
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</li>
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