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<meta name="keywords" content="C0015944, fetal membranes, premature rupture, finding, membrane premature rupture (pregnancy), membrane premature ruptures (pregnancy), pathologic function, prelabor rupture of membranes, premature rupture of fetal membranes, premature rupture of membrane, premature rupture of membrane (pregnancy), premature rupture of membranes, prom (pregnancy), prom - premature rupture of membranes, rupture of amniotic sac under 24 hours before onset of labor, rupture of membranes prior to onset of labor, term premature rupture of membranes, autosomal dominant, autosomal recessive, birth defects, chromosomal disease, chromosome, clinical features, clinical findings, clinical genetics, clinical recommendations, clinvar, congenital chromosomal disease, consumer genetic resources, cytogenetic location, disease characteristics, disease definitions, disease descriptions, disease ontology, disease synonyms, disease vocabulary, dysmorphology, entrez, familial disease, gene, gene-disease relationship, genereviews, genetic disease, genetic disorder, genetic terminology, genetic testing registry, genetics home reference, genomic disease, gtr, hereditary disease, heritable disease, hpo, human phenotype ontology, inherited disease, management guidelines, maternal inheritance, medgen, medical genetics, medical subject headings, mesh, mitochondrial inheritance, mode of inheritance, national center for biotechnology information, national institutes of health, national library of medicine, ncbi, nih, nlm, omim, ordo, orphanet, paternal inheritance, phenome, position statements, professional practice guidelines, rare disease, reference sequence, refseq, snomed ct, syndrome, undiagnosed diseases, x-linked recessive" /><meta name="description" content="Premature rupture of membranes (PROM) is a condition which occurs in pregnancy when the amniotic sac ruptures more than an hour before the onset of labor." /><meta name="robots" content="index,nofollow,noarchive" />
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<!--
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<!--imgCountBooks = 0--><h1 class="medgenTitle"><div class="MedGenTitleText">Premature rupture of membranes</div></h1><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>8826</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C0015944</a></dd><dt><span class="dotprefix"></span></dt><dd>Finding; Pathologic Function</dd></dl></div></div><table class="medgenTable"><tbody><tr><td>Synonyms:</td>
<td>Fetal Membranes, Premature Rupture; Membrane Premature Rupture (Pregnancy); Membrane Premature Ruptures (Pregnancy); Premature Rupture of Fetal Membranes; Premature Rupture of Membrane (Pregnancy); PROM (Pregnancy)</td></tr>
<tr><td><span class="bold">SNOMED CT: </span></td>
<td>PROM - Premature rupture of membranes (44223004); Rupture of membranes prior to onset of labor (44223004); Premature rupture of membranes (44223004); Rupture of amniotic sac under 24 hours before onset of labor (44223004)</td></tr>
<tr><td colspan="2" class="small"> </td></tr><tr><td>HPO:</td>
<td><a target="_blank" title="Human Phenotype Ontology" href="https://hpo.jax.org/app/browse/term/HP:0001788">HP:0001788</a></td></tr>
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Definition">Definition</h1><a sid="100" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln">Premature rupture of membranes (PROM) is a condition which occurs in pregnancy when the amniotic sac ruptures more than an hour before the onset of labor. [from <a title="Human Phenotype Ontology" href="http://www.human-phenotype-ontology.org" class="defSource" target="_blank">HPO</a>]</div>
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Term_Hierarchy">Term Hierarchy</h1><a sid="118" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln HierarchyGTR"><div class="jig-ncbitabs"><ul><li><a href="#tabGTR">GTR</a></li><li><a href="#tabMGEN">MeSH</a></li></ul><div id="tabGTR"><div class="search_result"><div class="rprts"><div class="chiclet_legend"><span class="chiclet_list" style="position:static;"><span title="Clinical test" class="chiclet Ccolor round">C</span><span>Clinical test,  </span><span title="Research test" class="chiclet Rcolor round">R</span><span>Research test,  </span><span title="OMIM" class="chiclet Ocolor ">O</span><span>OMIM,  </span><span title="GeneReview" class="chiclet Gcolor">G</span><span><em>GeneReviews</em>,  </span><span title="ClinVar" class="chiclet Vcolor">V</span><span>ClinVar  </span></span></div><div id="hierarchy" class="margin_t1"><div class="ds_tree"><ul><li class="matched_ds"><span class="chiclet_list"><span class="chiclet unavailable round" title="Clinical test">C</span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet unavailable" title="OMIM">O</span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet unavailable" title="ClinVar">V</span></span><span class="TLline">Premature rupture of membranes</span></li></ul></div></div></div></div></div><div id="tabMGEN"><div class="ds_tree"><ul><li><span class="TLline"><a href="/medgen/867443" ref="tree=MeSH" title="MedGen record for Phenotypic abnormality">Phenotypic abnormality</a></span><ul><li><span class="TLline"><a href="/medgen/871309" ref="tree=MeSH" title="MedGen record for Abnormality of prenatal development or birth">Abnormality of prenatal development or birth</a></span><ul><li><span class="TLline"><a href="/medgen/108202" ref="tree=MeSH" title="MedGen record for Abnormal delivery">Abnormal delivery</a></span><ul><li><span class="matched_ds">Premature rupture of membranes</span><ul><li><span class="TLline"><a href="/medgen/3056" ref="tree=MeSH" title="MedGen record for Chorioamnionitis">Chorioamnionitis</a></span><ul><li><span class="TLline"><a href="/medgen/823826" ref="tree=MeSH" title="MedGen record for Clinical Chorioamnionitis">Clinical Chorioamnionitis</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/342103" ref="tree=MeSH" title="MedGen record for Premature birth following premature rupture of fetal membranes">Premature birth following premature rupture of fetal membranes</a></span></li><li><span class="TLline"><a href="/medgen/147582" ref="tree=MeSH" title="MedGen record for Preterm premature rupture of membranes">Preterm premature rupture of membranes</a></span></li></ul></li></ul></li></ul></li></ul></li></ul></div></div></div></div>
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<div class="portlet mgSection" id="ID_112">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Conditions_with_this_feature">Conditions with this feature</h1><a sid="112" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln clinfeat">
<div class="divPopper rprt" id="rdis_1289"><div><strong>Achondroplasia</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1289</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C0001080</a></dd><dt><span class="dotprefix"></span></dt><dd>Congenital Abnormality</dd></dl></div></div></div>
<div class="spaceAbove">Achondroplasia is the most common cause of disproportionate short stature. Affected individuals have rhizomelic shortening of the limbs, macrocephaly, and characteristic facial features with frontal bossing and midface retrusion. In infancy, hypotonia is typical, and acquisition of developmental motor milestones is often both aberrant in pattern and delayed. Intelligence and life span are usually near normal, although craniocervical junction compression increases the risk of death in infancy. Additional complications include obstructive sleep apnea, middle ear dysfunction, kyphosis, and spinal stenosis.</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/1289">Condition Record</a></div></div>
<div class="divPopper rprt" id="rdis_120540"><div><strong>Pallister-Killian syndrome</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>120540</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C0265449</a></dd><dt><span class="dotprefix"></span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
<div class="spaceAbove">Pallister-Killian syndrome (PKS) is a dysmorphic condition involving most organ systems, but is also characterized by a tissue-limited mosaicism; most fibroblasts have 47 chromosomes with an extra small metacentric chromosome, whereas the karyotype of lymphocytes is normal. The extra metacentric chromosome is an isochromosome for part of the short arm of chromosome 12: i(12)(p10) (Peltomaki et al., 1987; Warburton et al., 1987).</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/120540">Condition Record</a></div></div>
<div class="divPopper rprt" id="rdis_75672"><div><strong>Ehlers-Danlos syndrome, kyphoscoliotic type 1</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>75672</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C0268342</a></dd><dt><span class="dotprefix"></span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
<div class="spaceAbove">PLOD1-related kyphoscoliotic Ehlers-Danlos syndrome (PLOD1-kEDS) is characterized by hypotonia, generalized joint hypermobility, early-onset kyphoscoliosis, skin fragility, and ocular abnormality. Intelligence is normal. Life span may be normal, but affected individuals are at risk of life-threatening arterial ruptures and spontaneous dissections of medium-sized arteries. Adults with severe kyphoscoliosis are at risk for complications from restrictive lung disease, recurrent pneumonia, and cardiac failure.</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/75672">Condition Record</a></div></div>
<div class="divPopper rprt" id="rdis_98030"><div><strong>Wrinkly skin syndrome</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>98030</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C0406587</a></dd><dt><span class="dotprefix"></span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
<div class="spaceAbove">ATP6V0A2-related cutis laxa is characterized by generalized cutis laxa, findings associated with generalized connective tissue disorder, developmental delays, and a variety of neurologic findings including abnormality on brain MRI. At birth, hypotonia, overfolded skin, and distinctive facial features are present and enlarged fontanelles are often observed. During childhood, the characteristic facial features and thick or coarse hair may become quite pronounced. The skin findings decrease with age, although easy bruising and Ehlers-Danlos-like scars have been described in some. In most (not all) affected individuals, cortical and cerebellar malformations are observed on brain MRI. Nearly all affected individuals have developmental delays, seizures, and neurologic regression.</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/98030">Condition Record</a></div></div>
<div class="divPopper rprt" id="rdis_147582"><div><strong>Preterm premature rupture of membranes</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>147582</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C0729264</a></dd><dt><span class="dotprefix"></span></dt><dd>Pathologic Function</dd></dl></div></div></div>
<div class="spaceAbove">Preterm premature rupture of the membranes (PPROM) is defined as rupture of membranes before 37 weeks of gestation, which occurs in approximately 3% of all pregnancies and accounts for about one-third of spontaneous preterm births (ACOG Practice Bulletin, 1998). Srinivas and Macones (2005) reviewed the pathophysiology of PPROM and noted that familial clustering and ethnic differences in the incidence of PPROM suggest possible genetic influences.</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/147582">Condition Record</a></div></div>
<div class="divPopper rprt" id="rdis_208652"><div><strong>Cholestasis-pigmentary retinopathy-cleft palate syndrome</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>208652</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C0795969</a></dd><dt><span class="dotprefix"></span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
<div class="spaceAbove">MED12-related disorders include the phenotypes of FG syndrome type 1 (FGS1), Lujan syndrome (LS), X-linked Ohdo syndrome (XLOS), Hardikar syndrome (HS), and nonspecific intellectual disability (NSID). FGS1 and LS share the clinical findings of cognitive impairment, hypotonia, and abnormalities of the corpus callosum. FGS1 is further characterized by absolute or relative macrocephaly, tall forehead, downslanted palpebral fissures, small and simple ears, constipation and/or anal anomalies, broad thumbs and halluces, and characteristic behavior. LS is further characterized by large head, tall thin body habitus, long thin face, prominent nasal bridge, high narrow palate, and short philtrum. Carrier females in families with FGS1 and LS are typically unaffected. XLOS is characterized by intellectual disability, blepharophimosis, and facial coarsening. HS has been described in females with cleft lip and/or cleft palate, biliary and liver anomalies, intestinal malrotation, pigmentary retinopathy, and coarctation of the aorta. Developmental and cognitive concerns have not been reported in females with HS. Pathogenic variants in MED12 have been reported in an increasing number of males and females with NSID, with affected individuals often having clinical features identified in other MED12-related disorders.</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/208652">Condition Record</a></div></div>
<div class="divPopper rprt" id="rdis_333324"><div><strong>TARP syndrome</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>333324</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C1839463</a></dd><dt><span class="dotprefix"></span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
<div class="spaceAbove">The classic features of TARP syndrome are talipes equinovarus, atrial septal defect, Robin sequence (micrognathia, cleft palate, and glossoptosis), and persistent left superior vena cava. Not all patients have all classic features. Some patients have the additional features of central nervous system dysfunction, renal abnormalities, variable cardiac anomalies including hypertrophic obstructive cardiomyopathy, and variable distal limb defects including syndactyly. Most patients die in late prenatal or early postnatal stages (summary by Kaeppler et al., 2018).</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/333324">Condition Record</a></div></div>
<div class="divPopper rprt" id="rdis_397792"><div><strong>Ehlers-Danlos syndrome, dermatosparaxis type</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>397792</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C2700425</a></dd><dt><span class="dotprefix"></span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
<div class="spaceAbove">Dermatosparaxis (meaning 'tearing of skin') is an autosomal recessive disorder of connective tissue resulting from deficiency of procollagen peptidase, an enzyme that aids in the processing of type I procollagen. The disorder and the responsible biochemical defect was first observed in cattle (Lapiere et al., 1971). Lapiere and Nusgens (1993) reviewed the discovery of dermatosparaxis in cattle, the elucidation of the disorder, its occurrence in other animals, and the delayed recognition of the disorder in the human.</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/397792">Condition Record</a></div></div>
<div class="divPopper rprt" id="rdis_862975"><div><strong>ADNP-related multiple congenital anomalies - intellectual disability - autism spectrum disorder</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>862975</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C4014538</a></dd><dt><span class="dotprefix"></span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
<div class="spaceAbove">ADNP-related disorder is characterized by hypotonia, severe speech and motor delay, mild-to-severe intellectual disability, and characteristic facial features (prominent forehead, high anterior hairline, wide and depressed nasal bridge, and short nose with full, upturned nasal tip) based on a cohort of 78 individuals. Features of autism spectrum disorder are common (stereotypic behavior, impaired social interaction). Other common findings include additional behavioral problems, sleep disturbance, brain abnormalities, seizures, feeding issues, gastrointestinal problems, visual dysfunction (hypermetropia, strabismus, cortical visual impairment), musculoskeletal anomalies, endocrine issues including short stature and hormonal deficiencies, cardiac and urinary tract anomalies, and hearing loss.</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/862975">Condition Record</a></div></div>
<div class="divPopper rprt" id="rdis_1675672"><div><strong>Polymicrogyria with or without vascular-type Ehlers-Danlos syndrome</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1675672</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C5193040</a></dd><dt><span class="dotprefix"></span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
<div class="spaceAbove">Polymicrogyria with or without vascular-type Ehlers-Danlos syndrome is an autosomal recessive disorder with a highly variable phenotype. Although all patients have polymicrogyria and other variable structural brain anomalies on imaging, only some show developmental delay and/or seizures. Similarly, only some patients have connective tissue defects that particularly affect the vascular system and can result in early death (summary by Vandervore et al., 2017).</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/1675672">Condition Record</a></div></div>
<div class="divPopper rprt" id="rdis_1784907"><div><strong>Marbach-Rustad progeroid syndrome</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1784907</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C5543388</a></dd><dt><span class="dotprefix"></span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
<div class="spaceAbove">Marbach-Rustad progeroid syndrome (MARUPS) is characterized by progeroid appearance with little subcutaneous fat and triangular facies, growth retardation with short stature, hypoplastic mandible crowded with unerupted supernumerary teeth, and cerebellar intention tremor. Psychomotor development is normal. Although features are reminiscent of Hutchinson-Gilford progeria syndrome (HGPS; 176670), MARUPS is less severe, with a relatively good prognosis. Two patients have been reported (Marbach et al., 2019).</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/1784907">Condition Record</a></div></div>
<div class="divPopper rprt" id="rdis_1794280"><div><strong>Immunodeficiency 87 and autoimmunity</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1794280</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C5562070</a></dd><dt><span class="dotprefix"></span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
<div class="spaceAbove">Immunodeficiency-87 and autoimmunity (IMD87) is an autosomal recessive immunologic disorder with wide phenotypic variation and severity. Affected individuals usually present in infancy or early childhood with increased susceptibility to infections, often Epstein-Barr virus (EBV), as well as with lymphadenopathy or autoimmune manifestations, predominantly hemolytic anemia. Laboratory studies may show low or normal lymphocyte numbers, often with skewed T-cell subset ratios. The disorder results primarily from defects in T-cell function, which causes both immunodeficiency and overall immune dysregulation (summary by Serwas et al., 2019 and Fournier et al., 2021).</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/1794280">Condition Record</a></div></div>
<div class="divPopper rprt" id="rdis_1800305"><div><strong>Progressive spondyloepimetaphyseal dysplasia-short stature-short fourth metatarsals-intellectual disability syndrome</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1800305</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C5568882</a></dd><dt><span class="dotprefix"></span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
<div class="spaceAbove">A rare genetic multiple congenital anomalies/dysmorphic syndrome with characteristics of global developmental delay and intellectual disability, progressive spondyloepimetaphyseal dysplasia, short stature, short fourth metatarsals and dysmorphic craniofacial features (including microcephaly, hypertelorism, epicanthal folds, mild ptosis, strabismus, malar hypoplasia, short nose, depressed nasal bridge, full lips, small, low-set ears and short neck). Craniosynostosis, generalized hypotonia, as well as asymmetry of the cerebral hemispheres and mild thinning of the corpus callosum on brain imaging have also been described.</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/1800305">Condition Record</a></div></div>
<div class="divPopper rprt" id="rdis_1812447"><div><strong>Restrictive dermopathy 1</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1812447</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C5676878</a></dd><dt><span class="dotprefix"></span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
<div class="spaceAbove">A restrictive dermopathy that has material basis in homozygous or compound heterozygous mutation in the ZMPSTE24 gene on chromosome 1p34.</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/1812447">Condition Record</a></div></div>
<div class="divPopper rprt" id="rdis_1847052"><div><strong>Long-Olsen-Distelmaier syndrome</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1847052</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C5882721</a></dd><dt><span class="dotprefix"></span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
<div class="spaceAbove">Long-Olsen-Distelmaier syndrome (LNGODS) is a severe, early-onset disease with multiple system involvement and lethal dilated cardiomyopathy (DCM) as a core clinical feature (summary by Reijnders et al., 2023).</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/1847052">Condition Record</a></div></div>
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1289" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Achondroplasia</a></div>
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_862975" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">ADNP-related multiple congenital anomalies - intellectual disability - autism spectrum disorder</a></div>
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_208652" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Cholestasis-pigmentary retinopathy-cleft palate syndrome</a></div>
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_397792" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Ehlers-Danlos syndrome, dermatosparaxis type</a></div>
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_75672" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Ehlers-Danlos syndrome, kyphoscoliotic type 1</a></div><div class="jig-moreless" data-jigconfig="class: 'moveDown', moreText: 'See full list (15)', lessText: 'Show less', nodeBefore: 0"><span id="clinMore">
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1794280" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Immunodeficiency 87 and autoimmunity</a></div>
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1847052" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Long-Olsen-Distelmaier syndrome</a></div>
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1784907" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Marbach-Rustad progeroid syndrome</a></div>
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_120540" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Pallister-Killian syndrome</a></div>
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1675672" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Polymicrogyria with or without vascular-type Ehlers-Danlos syndrome</a></div>
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_147582" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Preterm premature rupture of membranes</a></div>
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1800305" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Progressive spondyloepimetaphyseal dysplasia-short stature-short fourth metatarsals-intellectual disability syndrome</a></div>
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1812447" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Restrictive dermopathy 1</a></div>
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_333324" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">TARP syndrome</a></div>
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_98030" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Wrinkly skin syndrome</a></div></span></div></div>
</div>
<div class="portlet mgSection" id="ID_105">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Professional_guidelines">Professional guidelines</h1><a sid="105" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln"><h3 class="subhead">PubMed<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpPM"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3>
<div class="nl"><a target="_blank" href="/pubmed/36410937">Guideline No. 430: Diagnosis and management of preterm prelabour rupture of membranes.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Ronzoni S,
Boucoiran I,
Yudin MH,
Coolen J,
Pylypjuk C,
Melamed N,
Holden AC,
Smith G,
Barrett J</span><br />
<span class="medgenPMjournal">J Obstet Gynaecol Can</span>
2022 Nov;44(11):1193-1208.e1.
Epub 2022 Oct 2
doi: 10.1016/j.jogc.2022.08.014.
<span class="bold">PMID: </span><a href="/pubmed/36410937" target="_blank">36410937</a></div>
<div class="nl"><a target="_blank" href="/pubmed/34860784">Anemia in Pregnancy: Screening and Clinical Management Strategies.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Stanley AY,
Wallace JB,
Hernandez AM,
Spell JL</span><br />
<span class="medgenPMjournal">MCN Am J Matern Child Nurs</span>
2022 Jan-Feb 01;47(1):25-32.
doi: 10.1097/NMC.0000000000000787.
<span class="bold">PMID: </span><a href="/pubmed/34860784" target="_blank">34860784</a></div>
<div class="nl"><a target="_blank" href="/pubmed/29266075">ACOG Practice Bulletin No. 188: Prelabor Rupture of Membranes.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Committee on Practice Bulletins-Obstetrics</span><br />
<span class="medgenPMjournal">Obstet Gynecol</span>
2018 Jan;131(1):e1-e14.
doi: 10.1097/AOG.0000000000002455.
<span class="bold">PMID: </span><a href="/pubmed/29266075" target="_blank">29266075</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(%22premature%20rupture%20of%20membranes%22%5Btiab%3A~0%5D)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">See all (230)</a></div></div>
</div>
<div class="display-none help-popup" id="guidelinesHelpPM">These guidelines are articles in PubMed that match specific search criteria developed by MedGen to capture the most relevant practice guidelines. This list may not be comprehensive and may include broader topics as well. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div><div class="display-none help-popup" id="guidelinesHelpCurated">These guidelines are manually curated by the MedGen team
to supplement articles available in PubMed. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div>
<div class="portlet mgSection" id="ID_103">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_clinical_studies">Recent clinical studies</h1><a sid="103" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln"><h3 class="subhead">Etiology</h3>
<div class="nl"><a target="_blank" href="/pubmed/37094635">Efficacy of prophylactic antibiotics for preterm premature rupture of membranes: a systematic review and network meta-analysis.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Lin LL,
Hung JN,
Shiu SI,
Su YH,
Chen WC,
Tseng JJ</span><br />
<span class="medgenPMjournal">Am J Obstet Gynecol MFM</span>
2023 Jul;5(7):100978.
Epub 2023 Apr 23
doi: 10.1016/j.ajogmf.2023.100978.
<span class="bold">PMID: </span><a href="/pubmed/37094635" target="_blank">37094635</a></div>
<div class="nl"><a target="_blank" href="/pubmed/34954867">Antibiotic prophylaxis in preterm premature rupture of membranes at 24-31 weeks' gestation: Perinatal and 2-year outcomes in the EPIPAGE-2 cohort.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Lorthe E,
Letouzey M,
Torchin H,
Foix L'Helias L,
Gras-Le Guen C,
Benhammou V,
Boileau P,
Charlier C,
Kayem G;
EPIPAGE-2 Obstetric Writing Group</span><br />
<span class="medgenPMjournal">BJOG</span>
2022 Aug;129(9):1560-1573.
Epub 2022 Jan 13
doi: 10.1111/1471-0528.17081.
<span class="bold">PMID: </span><a href="/pubmed/34954867" target="_blank">34954867</a><a href="/pmc/articles/PMC9546066" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/33121653">Premature Rupture of Membranes: The Most Common Factor Leading to Preterm Birth.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Rayburn WF</span><br />
<span class="medgenPMjournal">Obstet Gynecol Clin North Am</span>
2020 Dec;47(4):xi-xii.
doi: 10.1016/j.ogc.2020.09.003.
<span class="bold">PMID: </span><a href="/pubmed/33121653" target="_blank">33121653</a></div>
<div class="nl"><a target="_blank" href="/pubmed/31112509">Preterm premature rupture of membranes (PPROM).</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Skupski D</span><br />
<span class="medgenPMjournal">J Perinat Med</span>
2019 Jul 26;47(5):491-492.
doi: 10.1515/jpm-2019-0163.
<span class="bold">PMID: </span><a href="/pubmed/31112509" target="_blank">31112509</a></div>
<div class="nl"><a target="_blank" href="/pubmed/27661655">Practice Bulletin No. 172: Premature Rupture of Membranes.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">American College of Obstetricians and Gynecologists Committee on Practice Bulletins—Obstetrics</span><br />
<span class="medgenPMjournal">Obstet Gynecol</span>
2016 Oct;128(4):e165-77.
doi: 10.1097/AOG.0000000000001712.
<span class="bold">PMID: </span><a href="/pubmed/27661655" target="_blank">27661655</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Premature%20rupture%20of%20membranes%22%20AND%20Etiology%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (2974)</a></div><h3 class="subhead">Diagnosis</h3>
<div class="nl"><a target="_blank" href="/pubmed/37175733">Biomarkers for Pregnancy Latency Prediction after Preterm Premature Rupture of Membranes-A Systematic Review.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Feduniw S,
Pruc M,
Ciebiera M,
Zeber-Lubecka N,
Massalska D,
Zgliczynska M,
Pawlowska A,
Szarpak L</span><br />
<span class="medgenPMjournal">Int J Mol Sci</span>
2023 Apr 28;24(9)
doi: 10.3390/ijms24098027.
<span class="bold">PMID: </span><a href="/pubmed/37175733" target="_blank">37175733</a><a href="/pmc/articles/PMC10178250" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/37094635">Efficacy of prophylactic antibiotics for preterm premature rupture of membranes: a systematic review and network meta-analysis.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Lin LL,
Hung JN,
Shiu SI,
Su YH,
Chen WC,
Tseng JJ</span><br />
<span class="medgenPMjournal">Am J Obstet Gynecol MFM</span>
2023 Jul;5(7):100978.
Epub 2023 Apr 23
doi: 10.1016/j.ajogmf.2023.100978.
<span class="bold">PMID: </span><a href="/pubmed/37094635" target="_blank">37094635</a></div>
<div class="nl"><a target="_blank" href="/pubmed/34860784">Anemia in Pregnancy: Screening and Clinical Management Strategies.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Stanley AY,
Wallace JB,
Hernandez AM,
Spell JL</span><br />
<span class="medgenPMjournal">MCN Am J Matern Child Nurs</span>
2022 Jan-Feb 01;47(1):25-32.
doi: 10.1097/NMC.0000000000000787.
<span class="bold">PMID: </span><a href="/pubmed/34860784" target="_blank">34860784</a></div>
<div class="nl"><a target="_blank" href="/pubmed/33121650">Periviable Premature Rupture of Membranes.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Gibson KS,
Brackney K</span><br />
<span class="medgenPMjournal">Obstet Gynecol Clin North Am</span>
2020 Dec;47(4):633-651.
Epub 2020 Oct 7
doi: 10.1016/j.ogc.2020.08.007.
<span class="bold">PMID: </span><a href="/pubmed/33121650" target="_blank">33121650</a></div>
<div class="nl"><a target="_blank" href="/pubmed/27661655">Practice Bulletin No. 172: Premature Rupture of Membranes.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">American College of Obstetricians and Gynecologists Committee on Practice Bulletins—Obstetrics</span><br />
<span class="medgenPMjournal">Obstet Gynecol</span>
2016 Oct;128(4):e165-77.
doi: 10.1097/AOG.0000000000001712.
<span class="bold">PMID: </span><a href="/pubmed/27661655" target="_blank">27661655</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Premature%20rupture%20of%20membranes%22%20AND%20Diagnosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (1290)</a></div><h3 class="subhead">Therapy</h3>
<div class="nl"><a target="_blank" href="/pubmed/33121650">Periviable Premature Rupture of Membranes.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Gibson KS,
Brackney K</span><br />
<span class="medgenPMjournal">Obstet Gynecol Clin North Am</span>
2020 Dec;47(4):633-651.
Epub 2020 Oct 7
doi: 10.1016/j.ogc.2020.08.007.
<span class="bold">PMID: </span><a href="/pubmed/33121650" target="_blank">33121650</a></div>
<div class="nl"><a target="_blank" href="/pubmed/30309793">Predictors of preterm birth.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Ville Y,
Rozenberg P</span><br />
<span class="medgenPMjournal">Best Pract Res Clin Obstet Gynaecol</span>
2018 Oct;52:23-32.
Epub 2018 Jul 7
doi: 10.1016/j.bpobgyn.2018.05.002.
<span class="bold">PMID: </span><a href="/pubmed/30309793" target="_blank">30309793</a></div>
<div class="nl"><a target="_blank" href="/pubmed/30016035">Preterm premature rupture of membranes.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Meller CH,
Carducci ME,
Ceriani Cernadas JM,
Otaño L</span><br />
<span class="medgenPMjournal">Arch Argent Pediatr</span>
2018 Aug 1;116(4):e575-e581.
doi: 10.5546/aap.2018.eng.e575.
<span class="bold">PMID: </span><a href="/pubmed/30016035" target="_blank">30016035</a></div>
<div class="nl"><a target="_blank" href="/pubmed/29266075">ACOG Practice Bulletin No. 188: Prelabor Rupture of Membranes.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Committee on Practice Bulletins-Obstetrics</span><br />
<span class="medgenPMjournal">Obstet Gynecol</span>
2018 Jan;131(1):e1-e14.
doi: 10.1097/AOG.0000000000002455.
<span class="bold">PMID: </span><a href="/pubmed/29266075" target="_blank">29266075</a></div>
<div class="nl"><a target="_blank" href="/pubmed/27661655">Practice Bulletin No. 172: Premature Rupture of Membranes.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">American College of Obstetricians and Gynecologists Committee on Practice Bulletins—Obstetrics</span><br />
<span class="medgenPMjournal">Obstet Gynecol</span>
2016 Oct;128(4):e165-77.
doi: 10.1097/AOG.0000000000001712.
<span class="bold">PMID: </span><a href="/pubmed/27661655" target="_blank">27661655</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Premature%20rupture%20of%20membranes%22%20AND%20Therapy%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (1246)</a></div><h3 class="subhead">Prognosis</h3>
<div class="nl"><a target="_blank" href="/pubmed/32295061">Risk Factors for Neonatal/Maternal Morbidity and Mortality in African American Women with Placental Abruption.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Elkafrawi D,
Sisti G,
Araji S,
Khoury A,
Miller J,
Rodriguez Echevarria B</span><br />
<span class="medgenPMjournal">Medicina (Kaunas)</span>
2020 Apr 13;56(4)
doi: 10.3390/medicina56040174.
<span class="bold">PMID: </span><a href="/pubmed/32295061" target="_blank">32295061</a><a href="/pmc/articles/PMC7230772" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/21890016">Abruption-associated prematurity.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Han CS,
Schatz F,
Lockwood CJ</span><br />
<span class="medgenPMjournal">Clin Perinatol</span>
2011 Sep;38(3):407-21.
doi: 10.1016/j.clp.2011.06.001.
<span class="bold">PMID: </span><a href="/pubmed/21890016" target="_blank">21890016</a><a href="/pmc/articles/PMC3175371" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/629062">Management of premature rupture of membranes.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Curet LB</span><br />
<span class="medgenPMjournal">Wis Med J</span>
1978 Jan;77(1):S13-S14.
<span class="bold">PMID: </span><a href="/pubmed/629062" target="_blank">629062</a></div>
<div class="nl"><a target="_blank" href="/pubmed/331207">Premature rupture of membranes and its effect on the newborn.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Bada HS,
Alojipan LC,
Andrews BF</span><br />
<span class="medgenPMjournal">Pediatr Clin North Am</span>
1977 Aug;24(3):491-500.
doi: 10.1016/s0031-3955(16)33459-9.
<span class="bold">PMID: </span><a href="/pubmed/331207" target="_blank">331207</a></div>
<div class="nl"><a target="_blank" href="/pubmed/6065981">Premature rupture of membranes and maternal death.</a></div>
<div class="portlet_content ln"><span class="medgenPMjournal">Br Med J</span>
1967 Dec 2;4(5578):504.
doi: 10.1136/bmj.4.5578.504.
<span class="bold">PMID: </span><a href="/pubmed/6065981" target="_blank">6065981</a><a href="/pmc/articles/PMC1749159" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Premature%20rupture%20of%20membranes%22%20AND%20Prognosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (1229)</a></div><h3 class="subhead">Clinical prediction guides</h3>
<div class="nl"><a target="_blank" href="/pubmed/38805904">Premature rupture of membranes and changes in the vaginal microbiome - Probiotics.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Gorczyca K,
Kozioł MM,
Kimber-Trojnar Ż,
Kępa J,
Satora M,
Rekowska AK,
Leszczyńska-Gorzelak B</span><br />
<span class="medgenPMjournal">Reprod Biol</span>
2024 Sep;24(3):100899.
Epub 2024 May 27
doi: 10.1016/j.repbio.2024.100899.
<span class="bold">PMID: </span><a href="/pubmed/38805904" target="_blank">38805904</a></div>
<div class="nl"><a target="_blank" href="/pubmed/38558850">Causal associations between Helicobacter pylori infection and pregnancy and neonatal outcomes: a two-sample Mendelian randomization study.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Huang J,
Liu Y,
Xu D,
Chen M,
Xie Q,
Chen J,
Xia L,
Yu L,
Wu Q,
Li Z,
Wang J,
Tian L</span><br />
<span class="medgenPMjournal">Front Cell Infect Microbiol</span>
2024;14:1343499.
Epub 2024 Mar 14
doi: 10.3389/fcimb.2024.1343499.
<span class="bold">PMID: </span><a href="/pubmed/38558850" target="_blank">38558850</a><a href="/pmc/articles/PMC10979540" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/38134338">Management and Interventions in Previable and Periviable Preterm Premature Rupture of Membranes: A Review.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Phillips A,
Pagan M,
Smith A,
Whitham M,
Magann EF</span><br />
<span class="medgenPMjournal">Obstet Gynecol Surv</span>
2023 Nov;78(11):682-689.
doi: 10.1097/OGX.0000000000001198.
<span class="bold">PMID: </span><a href="/pubmed/38134338" target="_blank">38134338</a></div>
<div class="nl"><a target="_blank" href="/pubmed/37175733">Biomarkers for Pregnancy Latency Prediction after Preterm Premature Rupture of Membranes-A Systematic Review.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Feduniw S,
Pruc M,
Ciebiera M,
Zeber-Lubecka N,
Massalska D,
Zgliczynska M,
Pawlowska A,
Szarpak L</span><br />
<span class="medgenPMjournal">Int J Mol Sci</span>
2023 Apr 28;24(9)
doi: 10.3390/ijms24098027.
<span class="bold">PMID: </span><a href="/pubmed/37175733" target="_blank">37175733</a><a href="/pmc/articles/PMC10178250" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/11914686">Preterm labour.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Terzidou V,
Bennett PR</span><br />
<span class="medgenPMjournal">Curr Opin Obstet Gynecol</span>
2002 Apr;14(2):105-13.
doi: 10.1097/00001703-200204000-00002.
<span class="bold">PMID: </span><a href="/pubmed/11914686" target="_blank">11914686</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Premature%20rupture%20of%20membranes%22%20AND%20Clinical%20prediction%20guides%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (1365)</a></div></div>
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<div class="nl"><a target="_blank" href="/pubmed/38553068">Risk factors for premature rupture of membranes in pregnant women: a systematic review and meta-analysis.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Lin D,
Hu B,
Xiu Y,
Ji R,
Zeng H,
Chen H,
Wu Y</span><br />
<span class="medgenPMjournal">BMJ Open</span>
2024 Mar 29;14(3):e077727.
doi: 10.1136/bmjopen-2023-077727.
<span class="bold">PMID: </span><a href="/pubmed/38553068" target="_blank">38553068</a><a href="/pmc/articles/PMC10982755" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/37175733">Biomarkers for Pregnancy Latency Prediction after Preterm Premature Rupture of Membranes-A Systematic Review.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Feduniw S,
Pruc M,
Ciebiera M,
Zeber-Lubecka N,
Massalska D,
Zgliczynska M,
Pawlowska A,
Szarpak L</span><br />
<span class="medgenPMjournal">Int J Mol Sci</span>
2023 Apr 28;24(9)
doi: 10.3390/ijms24098027.
<span class="bold">PMID: </span><a href="/pubmed/37175733" target="_blank">37175733</a><a href="/pmc/articles/PMC10178250" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/37094635">Efficacy of prophylactic antibiotics for preterm premature rupture of membranes: a systematic review and network meta-analysis.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Lin LL,
Hung JN,
Shiu SI,
Su YH,
Chen WC,
Tseng JJ</span><br />
<span class="medgenPMjournal">Am J Obstet Gynecol MFM</span>
2023 Jul;5(7):100978.
Epub 2023 Apr 23
doi: 10.1016/j.ajogmf.2023.100978.
<span class="bold">PMID: </span><a href="/pubmed/37094635" target="_blank">37094635</a></div>
<div class="nl"><a target="_blank" href="/pubmed/28407219">Multiple-micronutrient supplementation for women during pregnancy.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Haider BA,
Bhutta ZA</span><br />
<span class="medgenPMjournal">Cochrane Database Syst Rev</span>
2017 Apr 13;4(4):CD004905.
doi: 10.1002/14651858.CD004905.pub5.
<span class="bold">PMID: </span><a href="/pubmed/28407219" target="_blank">28407219</a><a href="/pmc/articles/PMC6478115" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/26837268">Subclinical Hypothyroidism in Pregnancy: A Systematic Review and Meta-Analysis.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Maraka S,
Ospina NM,
O'Keeffe DT,
Espinosa De Ycaza AE,
Gionfriddo MR,
Erwin PJ,
Coddington CC 3rd,
Stan MN,
Murad MH,
Montori VM</span><br />
<span class="medgenPMjournal">Thyroid</span>
2016 Apr;26(4):580-90.
Epub 2016 Mar 3
doi: 10.1089/thy.2015.0418.
<span class="bold">PMID: </span><a href="/pubmed/26837268" target="_blank">26837268</a><a href="/pmc/articles/PMC4827301" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Premature%20rupture%20of%20membranes%22%20AND%20systematic%5Bsb%5D%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (149)</a></div></div>
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<div class="portlet_content ln"><ul class="a_poppers"><li><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(%22premature%20rupture%20of%20membranes%22%5Btiab%3A~0%5D)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">PubMed</a><div class="help-popup">See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div></li><li><a target="_blank" href="/books/?term=((%22clinical%20guidelines%22%5BResource%20Type%5D)%20OR%20%22practice%20guideline%22%5BPublication%20Type%5D)%20AND%20(%22Premature%20rupture%20of%20membranes%22)">Bookshelf</a><div class="help-popup">See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div></li></ul></div>
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