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<!--
|
||
UID=812551
|
||
ConceptID=C3806221
|
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-->
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<!--imgCountBooks = 0--><h1 class="medgenTitle"><div class="MedGenTitleText">Giant melanosomes in melanocytes</div></h1><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>812551</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C3806221</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Finding</dd></dl></div></div><table class="medgenTable"><tbody><tr><td>Synonym:</td>
|
||
<td>Macromelanosomes</td></tr>
|
||
<tr><td colspan="2" class="small"> </td></tr><tr><td>HPO:</td>
|
||
<td><a target="_blank" title="Human Phenotype Ontology" href="https://hpo.jax.org/app/browse/term/HP:0005592">HP:0005592</a></td></tr>
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</tbody></table></div><div class="rprt-body jig-ncbiinpagenav" data-jigconfig="smoothScroll: false, gotoTopLink: true, gotoTopLinkText: '', gotoTopLinkAttrs: {'title': 'Go to the top of the page'},allHeadingLevels: ['h1'], topOfPageTOC: true, tocId: 'my-toc'"><div id="rprt-tabs-1" class="rprt-tab"><div id="tb-termsProp-1"><div class="leftCol mgCol"><div>
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<div class="portlet mgSection" id="ID_100">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Definition">Definition</h1><a sid="100" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln">The presence of large spherical melanosomes (1 to 6 micrometer in diameter) in the cytoplasm of melanocytes. [from <a title="Human Phenotype Ontology" href="http://www.human-phenotype-ontology.org" class="defSource" target="_blank">HPO</a>]</div>
|
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</div>
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||
<div class="portlet mgSection" id="ID_118">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Term_Hierarchy">Term Hierarchy</h1><a sid="118" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln HierarchyGTR"><div class="jig-ncbitabs"><ul><li><a href="#tabGTR">GTR</a></li><li><a href="#tabMGEN">MeSH</a></li></ul><div id="tabGTR"><div class="search_result"><div class="rprts"><div class="chiclet_legend"><span class="chiclet_list" style="position:static;"><span title="Clinical test" class="chiclet Ccolor round">C</span><span>Clinical test, </span><span title="Research test" class="chiclet Rcolor round">R</span><span>Research test, </span><span title="OMIM" class="chiclet Ocolor ">O</span><span>OMIM, </span><span title="GeneReview" class="chiclet Gcolor">G</span><span><em>GeneReviews</em>, </span><span title="ClinVar" class="chiclet Vcolor">V</span><span>ClinVar </span></span></div><div id="hierarchy" class="margin_t1"><div class="ds_tree"><ul><li class="matched_ds"><span class="chiclet_list"><span class="chiclet unavailable round" title="Clinical test">C</span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet unavailable" title="OMIM">O</span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet unavailable" title="ClinVar">V</span></span><span class="TLline">Giant melanosomes in melanocytes</span></li></ul></div></div></div></div></div><div id="tabMGEN"><div class="ds_tree"><ul><li><span class="TLline"><a href="/medgen/867443" ref="tree=MeSH" title="MedGen record for Phenotypic abnormality">Phenotypic abnormality</a></span><ul><li><span class="TLline"><a href="/medgen/871273" ref="tree=MeSH" title="MedGen record for Abnormality of the integument">Abnormality of the integument</a></span><ul><li><span class="TLline"><a href="/medgen/1845238" ref="tree=MeSH" title="MedGen record for Abnormality of the skin">Abnormality of the skin</a></span><ul><li><span class="TLline"><a href="/medgen/869110" ref="tree=MeSH" title="MedGen record for Abnormal skin morphology">Abnormal skin morphology</a></span><ul><li><span class="TLline"><a href="/medgen/224697" ref="tree=MeSH" title="MedGen record for Abnormality of skin pigmentation">Abnormality of skin pigmentation</a></span><ul><li><span class="TLline"><a href="/medgen/869107" ref="tree=MeSH" title="MedGen record for Abnormality of dermal melanosomes">Abnormality of dermal melanosomes</a></span><ul><li><span class="matched_ds">Giant melanosomes in melanocytes</span></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></div></div></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_112">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Conditions_with_this_feature">Conditions with this feature</h1><a sid="112" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln clinfeat">
|
||
<div class="divPopper rprt" id="rdis_3347"><div><strong>Chédiak-Higashi syndrome</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>3347</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information."><span class="highlight" style="background-color:">C0007965</span></a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Chediak-Higashi syndrome (CHS) is characterized by partial oculocutaneous albinism (OCA), immunodeficiency, a mild bleeding tendency, and late adolescent- to adult-onset neurologic manifestations (e.g., learning difficulties, peripheral neuropathy, ataxia, and parkinsonism). While present in nearly all individuals with CHS, these clinical findings vary in severity. Of note, all individuals with CHS are at risk of developing neurologic manifestations and hemophagocytic lymphohistiocytosis (HLH). Individuals with severe childhood-onset presentations are considered to have "classic" CHS, whereas individuals with milder adolescent- to adult-onset presentations are considered to have "atypical" CHS. Because of the considerable overlap between classic CHS and atypical CHS, the disorder is best understood as a continuum of severe to milder phenotypes, with the universal feature being the pathognomonic giant granules within leukocytes observed on peripheral blood smear.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/3347">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_120643"><div><strong>Aland island eye disease</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>120643</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0268505</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Aland Island eye disease (AIED) is an X-linked recessive retinal disease characterized by fundus hypopigmentation, decreased visual acuity, nystagmus, astigmatism, protan color vision defect (303900), progressive myopia, and defective dark adaptation. Although AIED has been referred to as a form of albinism, there is no misrouting of the optic nerves, which excludes it from the formal diagnosis of classic albinism (King et al., 2001).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/120643">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_90991"><div><strong>Ocular albinism, type I</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>90991</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0342684</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Ocular albinism type I (OA1) is the most common form of ocular albinism. Clinical presentation of OA1 in Caucasians is characterized by nystagmus, impaired visual acuity, iris hypopigmentation with translucency, albinotic fundus, macular hypoplasia, and normally pigmented skin and hair. Carrier females usually have punctate iris translucency and a mottled pattern of fundus pigmentation. In contrast to Caucasian patients, black or Japanese patients with OA1 often have brown irides with little or no translucency and varying degrees of fundus hypopigmentation, the so-called 'nonalbinotic fundus' (summary by Xiao and Zhang, 2009).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/90991">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_337149"><div><strong>Ocular albinism with late-onset sensorineural deafness</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>337149</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1845069</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Congenital Abnormality</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Ocular albinism is a genetic condition that primarily affects the eyes. This condition reduces the coloring (pigmentation) of the iris, which is the colored part of the eye, and the retina, which is the light-sensitive tissue at the back of the eye. Pigmentation in the eye is essential for normal vision.\n\nThe most common form of ocular albinism is known as the Nettleship-Falls type or type 1. Other forms of ocular albinism are much rarer and may be associated with additional signs and symptoms, such as hearing loss.\n\nOcular albinism is characterized by severely impaired sharpness of vision (visual acuity) and problems with combining vision from both eyes to perceive depth (stereoscopic vision). Although the vision loss is permanent, it does not worsen over time. Other eye abnormalities associated with this condition include rapid, involuntary eye movements (nystagmus); eyes that do not look in the same direction (strabismus); and increased sensitivity to light (photophobia). Many affected individuals also have abnormalities involving the optic nerves, which carry visual information from the eye to the brain.\n\nUnlike some other forms of albinism, ocular albinism does not significantly affect the color of the skin and hair. People with this condition may have a somewhat lighter complexion than other members of their family, but these differences are usually minor.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/337149">Condition Record</a></div></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_120643" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Aland island eye disease</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_3347" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Chédiak-Higashi syndrome</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_337149" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Ocular albinism with late-onset sensorineural deafness</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_90991" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Ocular albinism, type I</a></div></div>
|
||
</div>
|
||
<div class="display-none help-popup" id="guidelinesHelpPM">These guidelines are articles in PubMed that match specific search criteria developed by MedGen to capture the most relevant practice guidelines. This list may not be comprehensive and may include broader topics as well. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div><div class="display-none help-popup" id="guidelinesHelpCurated">These guidelines are manually curated by the MedGen team
|
||
to supplement articles available in PubMed. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div>
|
||
<div class="portlet mgSection" id="ID_103">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_clinical_studies">Recent clinical studies</h1><a sid="103" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">Etiology</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/27011171">Melanocytes Affect Nodal Expression and Signaling in Melanoma Cells: A Lesson from Pediatric Large Congenital Melanocytic Nevi.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Margaryan NV,
|
||
Gilgur A,
|
||
Seftor EA,
|
||
Purnell C,
|
||
Arva NC,
|
||
Gosain AK,
|
||
Hendrix MJ,
|
||
Strizzi L</span><br />
|
||
<span class="medgenPMjournal">Int J Mol Sci</span>
|
||
2016 Mar 22;17(3):418.
|
||
doi: 10.3390/ijms17030418.
|
||
<span class="bold">PMID: </span><a href="/pubmed/27011171" target="_blank">27011171</a><a href="/pmc/articles/PMC4813269" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/16115049">Melanocytic nevi are associated with neurofibromas in neurofibromatosis, type I, but not sporadic neurofibromas: a study of 226 cases.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Ball NJ,
|
||
Kho GT</span><br />
|
||
<span class="medgenPMjournal">J Cutan Pathol</span>
|
||
2005 Sep;32(8):523-32.
|
||
doi: 10.1111/j.0303-6987.2005.00376.x.
|
||
<span class="bold">PMID: </span><a href="/pubmed/16115049" target="_blank">16115049</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/9187835">Superficial spreading melanoma and blue naevus within naevus spilus--ultrastructural assessment of giant pigment granules.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Cox NH,
|
||
Malcolm A,
|
||
Long ED</span><br />
|
||
<span class="medgenPMjournal">Dermatology</span>
|
||
1997;194(3):213-6.
|
||
doi: 10.1159/000246104.
|
||
<span class="bold">PMID: </span><a href="/pubmed/9187835" target="_blank">9187835</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/1801653">The ultrastructure of congenital naevocytic naevi. III. Morphological variability of melanosomes.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Schneider BV,
|
||
Schnyder UW</span><br />
|
||
<span class="medgenPMjournal">Arch Dermatol Res</span>
|
||
1991;283(7):438-44.
|
||
doi: 10.1007/BF00371779.
|
||
<span class="bold">PMID: </span><a href="/pubmed/1801653" target="_blank">1801653</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/4078071">PUVA-induced melanocytic atypia: is it confined to PUVA lentigines?</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Abel EA,
|
||
Reid H,
|
||
Wood C,
|
||
Hu CH</span><br />
|
||
<span class="medgenPMjournal">J Am Acad Dermatol</span>
|
||
1985 Nov;13(5 Pt 1):761-8.
|
||
doi: 10.1016/s0190-9622(85)70219-8.
|
||
<span class="bold">PMID: </span><a href="/pubmed/4078071" target="_blank">4078071</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Giant%20melanosomes%20in%20melanocytes%22%20AND%20Etiology%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (7)</a></div><h3 class="subhead">Diagnosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/27011171">Melanocytes Affect Nodal Expression and Signaling in Melanoma Cells: A Lesson from Pediatric Large Congenital Melanocytic Nevi.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Margaryan NV,
|
||
Gilgur A,
|
||
Seftor EA,
|
||
Purnell C,
|
||
Arva NC,
|
||
Gosain AK,
|
||
Hendrix MJ,
|
||
Strizzi L</span><br />
|
||
<span class="medgenPMjournal">Int J Mol Sci</span>
|
||
2016 Mar 22;17(3):418.
|
||
doi: 10.3390/ijms17030418.
|
||
<span class="bold">PMID: </span><a href="/pubmed/27011171" target="_blank">27011171</a><a href="/pmc/articles/PMC4813269" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/10527680">Clinical, molecular, and cell biological aspects of Chediak-Higashi syndrome.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Introne W,
|
||
Boissy RE,
|
||
Gahl WA</span><br />
|
||
<span class="medgenPMjournal">Mol Genet Metab</span>
|
||
1999 Oct;68(2):283-303.
|
||
doi: 10.1006/mgme.1999.2927.
|
||
<span class="bold">PMID: </span><a href="/pubmed/10527680" target="_blank">10527680</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/8274781">Hermansky-Pudlak syndrome in a Swiss population.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Schallreuter KU,
|
||
Frenk E,
|
||
Wolfe LS,
|
||
Witkop CJ,
|
||
Wood JM</span><br />
|
||
<span class="medgenPMjournal">Dermatology</span>
|
||
1993;187(4):248-56.
|
||
doi: 10.1159/000247258.
|
||
<span class="bold">PMID: </span><a href="/pubmed/8274781" target="_blank">8274781</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/6816084">The nature and significance of macromelanosomes in pigmented skin lesions: their morphological characteristics, specificity for their occurrence, and possible mechanisms for their formation.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Jimbow K,
|
||
Horikoshi T</span><br />
|
||
<span class="medgenPMjournal">Am J Dermatopathol</span>
|
||
1982 Oct;4(5):413-20.
|
||
doi: 10.1097/00000372-198210000-00006.
|
||
<span class="bold">PMID: </span><a href="/pubmed/6816084" target="_blank">6816084</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/815911">Naevoid pigmentation with giant melanosomes (two cases).</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Eady RA,
|
||
Sparrow GP,
|
||
Grice K</span><br />
|
||
<span class="medgenPMjournal">Proc R Soc Med</span>
|
||
1975 Dec;68(12):759-61.
|
||
<span class="bold">PMID: </span><a href="/pubmed/815911" target="_blank">815911</a><a href="/pmc/articles/PMC1864367" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Giant%20melanosomes%20in%20melanocytes%22%20AND%20Diagnosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (15)</a></div><h3 class="subhead">Therapy</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/2948977">Melanosome macrocomplex: an ultrastructural component of patterned and nonpatterned seborrheic keratoses.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Shelley WB,
|
||
Shelley ED,
|
||
Burmeister V</span><br />
|
||
<span class="medgenPMjournal">J Am Acad Dermatol</span>
|
||
1987 Jan;16(1 Pt 1):124-8.
|
||
doi: 10.1016/s0190-9622(87)80175-5.
|
||
<span class="bold">PMID: </span><a href="/pubmed/2948977" target="_blank">2948977</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/4078071">PUVA-induced melanocytic atypia: is it confined to PUVA lentigines?</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Abel EA,
|
||
Reid H,
|
||
Wood C,
|
||
Hu CH</span><br />
|
||
<span class="medgenPMjournal">J Am Acad Dermatol</span>
|
||
1985 Nov;13(5 Pt 1):761-8.
|
||
doi: 10.1016/s0190-9622(85)70219-8.
|
||
<span class="bold">PMID: </span><a href="/pubmed/4078071" target="_blank">4078071</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/6703775">A semiquantitative light and electron microscopic analysis of histopathologic changes in photochemotherapy-induced freckles.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Kanerva L,
|
||
Niemi KM,
|
||
Lauharanta J</span><br />
|
||
<span class="medgenPMjournal">Arch Dermatol Res</span>
|
||
1984;276(1):2-11.
|
||
doi: 10.1007/BF00412555.
|
||
<span class="bold">PMID: </span><a href="/pubmed/6703775" target="_blank">6703775</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/624428">Alterations of the clinically noninvolved skin in patients with malignant melanoma. An electron microscopic study before and after repeated application of BCG.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Szekeres L,
|
||
Orfanos CE</span><br />
|
||
<span class="medgenPMjournal">Dermatologica</span>
|
||
1978;156(3):142-54.
|
||
doi: 10.1159/000250911.
|
||
<span class="bold">PMID: </span><a href="/pubmed/624428" target="_blank">624428</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Giant%20melanosomes%20in%20melanocytes%22%20AND%20Therapy%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (4)</a></div><h3 class="subhead">Prognosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/27011171">Melanocytes Affect Nodal Expression and Signaling in Melanoma Cells: A Lesson from Pediatric Large Congenital Melanocytic Nevi.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Margaryan NV,
|
||
Gilgur A,
|
||
Seftor EA,
|
||
Purnell C,
|
||
Arva NC,
|
||
Gosain AK,
|
||
Hendrix MJ,
|
||
Strizzi L</span><br />
|
||
<span class="medgenPMjournal">Int J Mol Sci</span>
|
||
2016 Mar 22;17(3):418.
|
||
doi: 10.3390/ijms17030418.
|
||
<span class="bold">PMID: </span><a href="/pubmed/27011171" target="_blank">27011171</a><a href="/pmc/articles/PMC4813269" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/9187835">Superficial spreading melanoma and blue naevus within naevus spilus--ultrastructural assessment of giant pigment granules.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Cox NH,
|
||
Malcolm A,
|
||
Long ED</span><br />
|
||
<span class="medgenPMjournal">Dermatology</span>
|
||
1997;194(3):213-6.
|
||
doi: 10.1159/000246104.
|
||
<span class="bold">PMID: </span><a href="/pubmed/9187835" target="_blank">9187835</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/8251363">Amelanotic malignant melanoma presenting as malignant schwannoma.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Schadendorf D,
|
||
Haas N,
|
||
Worm M,
|
||
Ostmeier H,
|
||
Kohlmus C,
|
||
Gottschalk J,
|
||
Algermissen B,
|
||
Jautzke G,
|
||
Czarnetzki BM</span><br />
|
||
<span class="medgenPMjournal">Br J Dermatol</span>
|
||
1993 Nov;129(5):609-14.
|
||
doi: 10.1111/j.1365-2133.1993.tb00496.x.
|
||
<span class="bold">PMID: </span><a href="/pubmed/8251363" target="_blank">8251363</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/8249191">Griscelli's syndrome: clinical features of three siblings.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Sanal O,
|
||
Küçükali T,
|
||
Ersoy F,
|
||
Tinaztepe K,
|
||
Göğüş S</span><br />
|
||
<span class="medgenPMjournal">Turk J Pediatr</span>
|
||
1993 Apr-Jun;35(2):115-9.
|
||
<span class="bold">PMID: </span><a href="/pubmed/8249191" target="_blank">8249191</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/921897">Eruptive naevi: report of two cases, with enzyme histochemical, light and electron microscopical findings.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Eady RA,
|
||
Gilkes JJ,
|
||
Jones EW</span><br />
|
||
<span class="medgenPMjournal">Br J Dermatol</span>
|
||
1977 Sep;97(3):267-78.
|
||
doi: 10.1111/j.1365-2133.1977.tb15182.x.
|
||
<span class="bold">PMID: </span><a href="/pubmed/921897" target="_blank">921897</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Giant%20melanosomes%20in%20melanocytes%22%20AND%20Prognosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (5)</a></div><h3 class="subhead">Clinical prediction guides</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/27011171">Melanocytes Affect Nodal Expression and Signaling in Melanoma Cells: A Lesson from Pediatric Large Congenital Melanocytic Nevi.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Margaryan NV,
|
||
Gilgur A,
|
||
Seftor EA,
|
||
Purnell C,
|
||
Arva NC,
|
||
Gosain AK,
|
||
Hendrix MJ,
|
||
Strizzi L</span><br />
|
||
<span class="medgenPMjournal">Int J Mol Sci</span>
|
||
2016 Mar 22;17(3):418.
|
||
doi: 10.3390/ijms17030418.
|
||
<span class="bold">PMID: </span><a href="/pubmed/27011171" target="_blank">27011171</a><a href="/pmc/articles/PMC4813269" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/25917897">Pathogenesis of multiple lentigines in LEOPARD syndrome with PTPN11 gene mutation.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Motegi S,
|
||
Yokoyama Y,
|
||
Ogino S,
|
||
Yamada K,
|
||
Uchiyama A,
|
||
Perera B,
|
||
Takeuchi Y,
|
||
Ohnishi H,
|
||
Ishikawa O</span><br />
|
||
<span class="medgenPMjournal">Acta Derm Venereol</span>
|
||
2015 Nov;95(8):978-84.
|
||
doi: 10.2340/00015555-2123.
|
||
<span class="bold">PMID: </span><a href="/pubmed/25917897" target="_blank">25917897</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/11092754">Oa1 knock-out: new insights on the pathogenesis of ocular albinism type 1.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Incerti B,
|
||
Cortese K,
|
||
Pizzigoni A,
|
||
Surace EM,
|
||
Varani S,
|
||
Coppola M,
|
||
Jeffery G,
|
||
Seeliger M,
|
||
Jaissle G,
|
||
Bennett DC,
|
||
Marigo V,
|
||
Schiaffino MV,
|
||
Tacchetti C,
|
||
Ballabio A</span><br />
|
||
<span class="medgenPMjournal">Hum Mol Genet</span>
|
||
2000 Nov 22;9(19):2781-8.
|
||
doi: 10.1093/hmg/9.19.2781.
|
||
<span class="bold">PMID: </span><a href="/pubmed/11092754" target="_blank">11092754</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/2355182">Ultrastructural observations on the hair bulb melanocytes and melanosomes in acute alopecia areata.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Tobin DJ,
|
||
Fenton DA,
|
||
Kendall MD</span><br />
|
||
<span class="medgenPMjournal">J Invest Dermatol</span>
|
||
1990 Jun;94(6):803-7.
|
||
doi: 10.1111/1523-1747.ep12874660.
|
||
<span class="bold">PMID: </span><a href="/pubmed/2355182" target="_blank">2355182</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/7223721">The ocular pigmentary disturbance of human Chédiak-Higashi syndrome. A comparative light- and electron-microscopic study and review of the literature.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Valenzuela R,
|
||
Morningstar WA</span><br />
|
||
<span class="medgenPMjournal">Am J Clin Pathol</span>
|
||
1981 Apr;75(4):591-6.
|
||
doi: 10.1093/ajcp/75.4.591.
|
||
<span class="bold">PMID: </span><a href="/pubmed/7223721" target="_blank">7223721</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Giant%20melanosomes%20in%20melanocytes%22%20AND%20Clinical%20prediction%20guides%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (15)</a></div></div>
|
||
</div>
|
||
</div></div></div></div></div></div></div>
|
||
<div id="messagearea_bottom">
|
||
|
||
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|
||
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||
|
||
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||
|
||
</div>
|
||
</div>
|
||
<div class="supplemental col three_col last">
|
||
<h2 class="offscreen_noflow">Supplemental Content</h2>
|
||
|
||
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|
||
|
||
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||
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<div class="portlet mgSection" id="ID_113">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Table_of_contents">Table of contents</h1><a sid="113" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Clinical_resources">Clinical resources</h1><a sid="119" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="portlet_content ln"><ul><li><a href="https://clinicaltrials.gov/search?cond=Giant%20melanosomes%20in%20melanocytes" target="_blank">ClinicalTrials.gov</a></li></ul></div>
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Consumer_resources">Consumer resources</h1><a sid="116" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="portlet_content ln"><ul><li><a href="https://vsearch.nlm.nih.gov/vivisimo/cgi-bin/query-meta?v:project=medlineplus&query=Giant%20melanosomes%20in%20melanocytes" target="_blank">MedlinePlus</a></li></ul></div>
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<div class="portlet brieflink">
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<div class="portlet_head">
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<div class="portlet_title">
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<h3>Reviews</h3>
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