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<!--
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||
UID=76094
|
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ConceptID=C0280313
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-->
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<!--imgCountBooks = 0--><h1 class="medgenTitle"><div class="MedGenTitleText">Oropharyngeal squamous cell carcinoma</div></h1><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>76094</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0280313</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Neoplastic Process</dd></dl></div></div><table class="medgenTable"><tbody><tr><td>Synonym:</td>
|
||
<td>Oropharynx squamous cell carcinoma</td></tr>
|
||
<tr><td><span class="bold">SNOMED CT: </span></td>
|
||
<td>Squamous cell carcinoma of oropharynx (423464009); Primary squamous cell carcinoma of oropharynx (707585008); Cancer of oropharynx, squamous cell (423464009)</td></tr>
|
||
<tr><td colspan="2" class="small"> </td></tr><tr><td>HPO:</td>
|
||
<td><a target="_blank" title="Human Phenotype Ontology" href="https://hpo.jax.org/app/browse/term/HP:0012182">HP:0012182</a></td></tr>
|
||
<tr><td>Monarch Initiative:</td>
|
||
<td><a href="https://monarchinitiative.org/disease/MONDO:0044704" target="_blank">MONDO:0044704</a></td></tr>
|
||
<tr><td>Orphanet:</td>
|
||
<td><a target="_blank" title="Orphanet: The portal for rare diseases and orphan drugs" href="http://www.orpha.net/consor/cgi-bin/OC_Exp.php?lng=EN&Expert=500478">ORPHA500478</a></td></tr></tbody></table></div><div class="rprt-body jig-ncbiinpagenav" data-jigconfig="smoothScroll: false, gotoTopLink: true, gotoTopLinkText: '', gotoTopLinkAttrs: {'title': 'Go to the top of the page'},allHeadingLevels: ['h1'], topOfPageTOC: true, tocId: 'my-toc'"><div id="rprt-tabs-1" class="rprt-tab"><div id="tb-termsProp-1"><div class="leftCol mgCol"><div>
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<div class="portlet mgSection" id="ID_100">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Definition">Definition</h1><a sid="100" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln">A squamous cell carcinoma that originates in the oropharnyx. [from <a title="Human Phenotype Ontology" href="http://www.human-phenotype-ontology.org" class="defSource" target="_blank">HPO</a>]</div>
|
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</div>
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<div class="portlet mgSection" id="ID_118">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Term_Hierarchy">Term Hierarchy</h1><a sid="118" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
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<div class="portlet_content ln HierarchyGTR"><div class="jig-ncbitabs"><ul><li><a href="#tabGTR">GTR</a></li><li><a href="#tabMGEN">MeSH</a></li></ul><div id="tabGTR"><div class="search_result"><div class="rprts"><div class="chiclet_legend"><span class="chiclet_list" style="position:static;"><span title="Clinical test" class="chiclet Ccolor round">C</span><span>Clinical test, </span><span title="Research test" class="chiclet Rcolor round">R</span><span>Research test, </span><span title="OMIM" class="chiclet Ocolor ">O</span><span>OMIM, </span><span title="GeneReview" class="chiclet Gcolor">G</span><span><em>GeneReviews</em>, </span><span title="ClinVar" class="chiclet Vcolor">V</span><span>ClinVar </span></span></div><div id="hierarchy" class="margin_t1"><div class="ds_tree"><ul><li class="matched_ds"><span class="chiclet_list"><span class="chiclet unavailable round" title="Clinical test">C</span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet unavailable" title="OMIM">O</span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet unavailable" title="ClinVar">V</span></span><span class="TLline">Oropharyngeal squamous cell carcinoma</span></li></ul></div></div></div></div></div><div id="tabMGEN"><div class="ds_tree"><ul><li><span class="TLline"><a href="/medgen/21047" ref="tree=MeSH" title="MedGen record for Pathological Conditions, Signs and Symptoms">Pathological Conditions, Signs and Symptoms</a></span><ul><li><span class="TLline"><a href="/medgen/18325" ref="tree=MeSH" title="MedGen record for Pathological process">Pathological process</a></span><ul><li><span class="TLline"><a href="/medgen/4347" ref="tree=MeSH" title="MedGen record for Disease">Disease</a></span><ul><li><span class="TLline"><a href="/medgen/10294" ref="tree=MeSH" title="MedGen record for Neoplasm">Neoplasm</a></span><ul><li><span class="matched_ds">Oropharyngeal squamous cell carcinoma</span><ul><li><span class="TLline"><a href="/medgen/124732" ref="tree=MeSH" title="MedGen record for Metastatic Oropharyngeal Squamous Cell Carcinoma">Metastatic Oropharyngeal Squamous Cell Carcinoma</a></span><ul><li><span class="TLline"><a href="/medgen/1661808" ref="tree=MeSH" title="MedGen record for Advanced Oropharyngeal Squamous Cell Carcinoma">Advanced Oropharyngeal Squamous Cell Carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/1693245" ref="tree=MeSH" title="MedGen record for Locally Advanced Oropharyngeal Squamous Cell Carcinoma">Locally Advanced Oropharyngeal Squamous Cell Carcinoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/926083" ref="tree=MeSH" title="MedGen record for Oropharyngeal Basaloid Squamous Cell Carcinoma">Oropharyngeal Basaloid Squamous Cell Carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/1755712" ref="tree=MeSH" title="MedGen record for Oropharyngeal Human Papillomavirus-Independent Squamous Cell Carcinoma">Oropharyngeal Human Papillomavirus-Independent Squamous Cell Carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/415751" ref="tree=MeSH" title="MedGen record for Oropharyngeal Human Papillomavirus-Related Squamous Cell Carcinoma">Oropharyngeal Human Papillomavirus-Related Squamous Cell Carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/1636921" ref="tree=MeSH" title="MedGen record for Oropharyngeal p16INK4a-Negative Squamous Cell Carcinoma">Oropharyngeal p16INK4a-Negative Squamous Cell Carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/926082" ref="tree=MeSH" title="MedGen record for Oropharyngeal Poorly Differentiated Carcinoma">Oropharyngeal Poorly Differentiated Carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/76095" ref="tree=MeSH" title="MedGen record for Oropharyngeal Undifferentiated Carcinoma">Oropharyngeal Undifferentiated Carcinoma</a></span><ul><li><span class="TLline"><a href="/medgen/857327" ref="tree=MeSH" title="MedGen record for Recurrent Oropharyngeal Undifferentiated Carcinoma">Recurrent Oropharyngeal Undifferentiated Carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/852487" ref="tree=MeSH" title="MedGen record for Stage I Oropharyngeal Undifferentiated Carcinoma AJCC v6 and v7">Stage I Oropharyngeal Undifferentiated Carcinoma AJCC v6 and v7</a></span></li><li><span class="TLline"><a href="/medgen/857132" ref="tree=MeSH" title="MedGen record for Stage II Oropharyngeal Undifferentiated Carcinoma AJCC v6 and v7">Stage II Oropharyngeal Undifferentiated Carcinoma AJCC v6 and v7</a></span></li><li><span class="TLline"><a href="/medgen/852488" ref="tree=MeSH" title="MedGen record for Stage III Oropharyngeal Undifferentiated Carcinoma AJCC v7">Stage III Oropharyngeal Undifferentiated Carcinoma AJCC v7</a></span></li><li><span class="TLline"><a href="/medgen/852489" ref="tree=MeSH" title="MedGen record for Stage IV Oropharyngeal Undifferentiated Carcinoma AJCC v7">Stage IV Oropharyngeal Undifferentiated Carcinoma AJCC v7</a></span><ul><li><span class="TLline"><a href="/medgen/857115" ref="tree=MeSH" title="MedGen record for Stage IVA Oropharyngeal Undifferentiated Carcinoma AJCC v7">Stage IVA Oropharyngeal Undifferentiated Carcinoma AJCC v7</a></span></li><li><span class="TLline"><a href="/medgen/857108" ref="tree=MeSH" title="MedGen record for Stage IVB Oropharyngeal Undifferentiated Carcinoma AJCC v7">Stage IVB Oropharyngeal Undifferentiated Carcinoma AJCC v7</a></span></li><li><span class="TLline"><a href="/medgen/857102" ref="tree=MeSH" title="MedGen record for Stage IVC Oropharyngeal Undifferentiated Carcinoma AJCC v7">Stage IVC Oropharyngeal Undifferentiated Carcinoma AJCC v7</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/277822" ref="tree=MeSH" title="MedGen record for Tonsillar Undifferentiated Carcinoma">Tonsillar Undifferentiated Carcinoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/79109" ref="tree=MeSH" title="MedGen record for Recurrent Oropharyngeal Squamous Cell Carcinoma">Recurrent Oropharyngeal Squamous Cell Carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/1669285" ref="tree=MeSH" title="MedGen record for Refractory Oropharyngeal Squamous Cell Carcinoma">Refractory Oropharyngeal Squamous Cell Carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/1694101" ref="tree=MeSH" title="MedGen record for Resectable Oropharyngeal Squamous Cell Carcinoma">Resectable Oropharyngeal Squamous Cell Carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/148181" ref="tree=MeSH" title="MedGen record for Soft Palate Squamous Cell Carcinoma">Soft Palate Squamous Cell Carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/163662" ref="tree=MeSH" title="MedGen record for Stage 0 Oropharyngeal Squamous Cell Carcinoma AJCC v6 and v7">Stage 0 Oropharyngeal Squamous Cell Carcinoma AJCC v6 and v7</a></span></li><li><span class="TLline"><a href="/medgen/76103" ref="tree=MeSH" title="MedGen record for Stage I Oropharyngeal Squamous Cell Carcinoma AJCC v6 and v7">Stage I Oropharyngeal Squamous Cell Carcinoma AJCC v6 and v7</a></span></li><li><span class="TLline"><a href="/medgen/83640" ref="tree=MeSH" title="MedGen record for Stage II Oropharyngeal Squamous Cell Carcinoma AJCC v6 and v7">Stage II Oropharyngeal Squamous Cell Carcinoma AJCC v6 and v7</a></span></li><li><span class="TLline"><a href="/medgen/124731" ref="tree=MeSH" title="MedGen record for Stage III Oropharyngeal Squamous Cell Carcinoma AJCC v7">Stage III Oropharyngeal Squamous Cell Carcinoma AJCC v7</a></span></li><li><span class="TLline"><a href="/medgen/1669998" ref="tree=MeSH" title="MedGen record for Stage IV Oropharyngeal Squamous Cell Carcinoma AJCC v7">Stage IV Oropharyngeal Squamous Cell Carcinoma AJCC v7</a></span><ul><li><span class="TLline"><a href="/medgen/234870" ref="tree=MeSH" title="MedGen record for Stage IVA Oropharyngeal Squamous Cell Carcinoma AJCC v7">Stage IVA Oropharyngeal Squamous Cell Carcinoma AJCC v7</a></span></li><li><span class="TLline"><a href="/medgen/234875" ref="tree=MeSH" title="MedGen record for Stage IVB Oropharyngeal Squamous Cell Carcinoma AJCC v7">Stage IVB Oropharyngeal Squamous Cell Carcinoma AJCC v7</a></span></li><li><span class="TLline"><a href="/medgen/233529" ref="tree=MeSH" title="MedGen record for Stage IVC Oropharyngeal Squamous Cell Carcinoma AJCC v7">Stage IVC Oropharyngeal Squamous Cell Carcinoma AJCC v7</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/79101" ref="tree=MeSH" title="MedGen record for Tonsillar squamous cell carcinoma">Tonsillar squamous cell carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/1704184" ref="tree=MeSH" title="MedGen record for Unresectable Oropharyngeal Squamous Cell Carcinoma">Unresectable Oropharyngeal Squamous Cell Carcinoma</a></span></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></div></div></div></div>
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|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Conditions_with_this_feature">Conditions with this feature</h1><a sid="112" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln clinfeat">
|
||
<div class="divPopper rprt" id="rdis_216941"><div><strong>Dyskeratosis congenita, X-linked</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>216941</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1148551</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Dyskeratosis congenita and related telomere biology disorders (DC/TBD) are caused by impaired telomere maintenance resulting in short or very short telomeres. The phenotypic spectrum of telomere biology disorders is broad and includes individuals with classic dyskeratosis congenita (DC) as well as those with very short telomeres and an isolated physical finding. Classic DC is characterized by a triad of dysplastic nails, lacy reticular pigmentation of the upper chest and/or neck, and oral leukoplakia, although this may not be present in all individuals. People with DC/TBD are at increased risk for progressive bone marrow failure (BMF), myelodysplastic syndrome or acute myelogenous leukemia, solid tumors (usually squamous cell carcinoma of the head/neck or anogenital cancer), and pulmonary fibrosis. Other findings can include eye abnormalities (epiphora, blepharitis, sparse eyelashes, ectropion, entropion, trichiasis), taurodontism, liver disease, gastrointestinal telangiectasias, and avascular necrosis of the hips or shoulders. Although most persons with DC/TBD have normal psychomotor development and normal neurologic function, significant developmental delay is present in both forms; additional findings include cerebellar hypoplasia (Hoyeraal Hreidarsson syndrome) and bilateral exudative retinopathy and intracranial calcifications (Revesz syndrome and Coats plus syndrome). Onset and progression of manifestations of DC/TBD vary: at the mild end of the spectrum are those who have only minimal physical findings with normal bone marrow function, and at the severe end are those who have the diagnostic triad and early-onset BMF.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/216941">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_325450"><div><strong>Melanoma-pancreatic cancer syndrome</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>325450</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1838547</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Melanoma-pancreatic cancer syndrome is an inherited cancer predisposition syndrome in which mutation carriers have an increased risk of developing malignant melanoma and/or pancreatic cancer. Mutation carriers within families may develop either or both types of cancer (summary by Harinck et al., 2012). For background and phenotypic information on malignant melanoma and pancreatic cancer, see 155600 and 260350, respectively.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/325450">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_482833"><div><strong>Familial cutaneous telangiectasia and oropharyngeal predisposition cancer syndrome</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>482833</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C3281203</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Neoplastic Process</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Patients with familial cutaneous telangiectasia and cancer syndrome (FCTCS) develop cutaneous telangiectases in infancy with patchy alopecia over areas of affected skin, thinning of the lateral eyebrows, and mild dental and nail anomalies. Affected individuals are at increased risk of developing oropharyngeal cancer, and other malignancies have been reported as well (Tanaka et al., 2012).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/482833">Condition Record</a></div></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_216941" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Dyskeratosis congenita, X-linked</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_482833" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Familial cutaneous telangiectasia and oropharyngeal predisposition cancer syndrome</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_325450" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Melanoma-pancreatic cancer syndrome</a></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_105">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Professional_guidelines">Professional guidelines</h1><a sid="105" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">PubMed<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpPM"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/39078350">Radiation Therapy for HPV-Positive Oropharyngeal Squamous Cell Carcinoma: An ASTRO Clinical Practice Guideline.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Margalit DN,
|
||
Anker CJ,
|
||
Aristophanous M,
|
||
Awan M,
|
||
Bajaj GK,
|
||
Bradfield L,
|
||
Califano J,
|
||
Caudell JJ,
|
||
Chapman CH,
|
||
Garden AS,
|
||
Harari PM,
|
||
Helms A,
|
||
Lin A,
|
||
Maghami E,
|
||
Mehra R,
|
||
Parker L,
|
||
Shnayder Y,
|
||
Spencer S,
|
||
Swiecicki PL,
|
||
Tsai JC,
|
||
Sher DJ</span><br />
|
||
<span class="medgenPMjournal">Pract Radiat Oncol</span>
|
||
2024 Sep-Oct;14(5):398-425.
|
||
Epub 2024 Jun 18
|
||
doi: 10.1016/j.prro.2024.05.007.
|
||
<span class="bold">PMID: </span><a href="/pubmed/39078350" target="_blank">39078350</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/35105976">HPV-associated oropharyngeal cancer: epidemiology, molecular biology and clinical management.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Lechner M,
|
||
Liu J,
|
||
Masterson L,
|
||
Fenton TR</span><br />
|
||
<span class="medgenPMjournal">Nat Rev Clin Oncol</span>
|
||
2022 May;19(5):306-327.
|
||
Epub 2022 Feb 1
|
||
doi: 10.1038/s41571-022-00603-7.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35105976" target="_blank">35105976</a><a href="/pmc/articles/PMC8805140" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/34929047">Interventions for the treatment of oral cavity and oropharyngeal cancer: chemotherapy.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Parmar A,
|
||
Macluskey M,
|
||
Mc Goldrick N,
|
||
Conway DI,
|
||
Glenny AM,
|
||
Clarkson JE,
|
||
Worthington HV,
|
||
Chan KK</span><br />
|
||
<span class="medgenPMjournal">Cochrane Database Syst Rev</span>
|
||
2021 Dec 20;12(12):CD006386.
|
||
doi: 10.1002/14651858.CD006386.pub4.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34929047" target="_blank">34929047</a><a href="/pmc/articles/PMC8687638" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(%22oropharyngeal%20squamous%20cell%20carcinoma%22%5Btiab%3A~0%5D)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">See all (244)</a></div><h3 class="subhead">Curated<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpCurated"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3><h3 class="nl vspace"><a href="https://www.nccn.org/professionals/physician_gls/pdf/head-and-neck.pdf" target="_blank">NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®), Head and Neck Cancers, 2024</a></h3>
|
||
</div>
|
||
</div>
|
||
<div class="display-none help-popup" id="guidelinesHelpPM">These guidelines are articles in PubMed that match specific search criteria developed by MedGen to capture the most relevant practice guidelines. This list may not be comprehensive and may include broader topics as well. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div><div class="display-none help-popup" id="guidelinesHelpCurated">These guidelines are manually curated by the MedGen team
|
||
to supplement articles available in PubMed. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div>
|
||
<div class="portlet mgSection" id="ID_103">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_clinical_studies">Recent clinical studies</h1><a sid="103" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">Etiology</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/36306202">Distant metastases in human papillomavirus-related oropharyngeal squamous cell carcinoma: Systematic review and meta-analysis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Crossley JR,
|
||
Nelson LL,
|
||
Chou J,
|
||
Maxwell JH</span><br />
|
||
<span class="medgenPMjournal">Head Neck</span>
|
||
2023 Jan;45(1):275-282.
|
||
Epub 2022 Oct 28
|
||
doi: 10.1002/hed.27230.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36306202" target="_blank">36306202</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/34379804">A proposal for risk-based and strategy-adapted de-escalation in human papillomavirus-positive oropharyngeal squamous cell carcinoma.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Wotman MT,
|
||
Miles BA,
|
||
Bakst RL,
|
||
Posner MR</span><br />
|
||
<span class="medgenPMjournal">Cancer</span>
|
||
2021 Dec 1;127(23):4330-4338.
|
||
Epub 2021 Aug 11
|
||
doi: 10.1002/cncr.33851.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34379804" target="_blank">34379804</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/32247987">Deintensification of treatment for human papillomavirus-related oropharyngeal cancer: Current state and future directions.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Bigelow EO,
|
||
Seiwert TY,
|
||
Fakhry C</span><br />
|
||
<span class="medgenPMjournal">Oral Oncol</span>
|
||
2020 Jun;105:104652.
|
||
Epub 2020 Apr 2
|
||
doi: 10.1016/j.oraloncology.2020.104652.
|
||
<span class="bold">PMID: </span><a href="/pubmed/32247987" target="_blank">32247987</a><a href="/pmc/articles/PMC8035753" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/29710071">Age Profile of Patients With Oropharyngeal Squamous Cell Carcinoma.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Rettig EM,
|
||
Fakhry C,
|
||
Khararjian A,
|
||
Westra WH</span><br />
|
||
<span class="medgenPMjournal">JAMA Otolaryngol Head Neck Surg</span>
|
||
2018 Jun 1;144(6):538-539.
|
||
doi: 10.1001/jamaoto.2018.0310.
|
||
<span class="bold">PMID: </span><a href="/pubmed/29710071" target="_blank">29710071</a><a href="/pmc/articles/PMC5933458" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/25654476">HPV and cancer of the oral cavity.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Hübbers CU,
|
||
Akgül B</span><br />
|
||
<span class="medgenPMjournal">Virulence</span>
|
||
2015;6(3):244-8.
|
||
doi: 10.1080/21505594.2014.999570.
|
||
<span class="bold">PMID: </span><a href="/pubmed/25654476" target="_blank">25654476</a><a href="/pmc/articles/PMC4601238" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Oropharyngeal%20squamous%20cell%20carcinoma%22%20AND%20Etiology%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (1631)</a></div><h3 class="subhead">Diagnosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/38729119">MRI-based deep learning and radiomics for prediction of occult cervical lymph node metastasis and prognosis in early-stage oral and oropharyngeal squamous cell carcinoma: a diagnostic study.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Lan T,
|
||
Kuang S,
|
||
Liang P,
|
||
Ning C,
|
||
Li Q,
|
||
Wang L,
|
||
Wang Y,
|
||
Lin Z,
|
||
Hu H,
|
||
Yang L,
|
||
Li J,
|
||
Liu J,
|
||
Li Y,
|
||
Wu F,
|
||
Chai H,
|
||
Song X,
|
||
Huang Y,
|
||
Duan X,
|
||
Zeng D,
|
||
Li J,
|
||
Cao H</span><br />
|
||
<span class="medgenPMjournal">Int J Surg</span>
|
||
2024 Aug 1;110(8):4648-4659.
|
||
doi: 10.1097/JS9.0000000000001578.
|
||
<span class="bold">PMID: </span><a href="/pubmed/38729119" target="_blank">38729119</a><a href="/pmc/articles/PMC11325978" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/37070629">Novel HPV Associated Oropharyngeal Squamous Cell Carcinoma Surveillance DNA Assay Cost Analysis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Lin MG,
|
||
Zhu A,
|
||
Read PW,
|
||
Garneau J,
|
||
McLaughlin C</span><br />
|
||
<span class="medgenPMjournal">Laryngoscope</span>
|
||
2023 Nov;133(11):3006-3012.
|
||
Epub 2023 Apr 18
|
||
doi: 10.1002/lary.30701.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37070629" target="_blank">37070629</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/36420924">Role of oral microbiome in oral oncogenesis, tumor progression, and metastasis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Li R,
|
||
Xiao L,
|
||
Gong T,
|
||
Liu J,
|
||
Li Y,
|
||
Zhou X,
|
||
Li Y,
|
||
Zheng X</span><br />
|
||
<span class="medgenPMjournal">Mol Oral Microbiol</span>
|
||
2023 Feb;38(1):9-22.
|
||
Epub 2022 Dec 10
|
||
doi: 10.1111/omi.12403.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36420924" target="_blank">36420924</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/32077795">Improving Oral Cancer Outcomes with Imaging and Artificial Intelligence.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Ilhan B,
|
||
Lin K,
|
||
Guneri P,
|
||
Wilder-Smith P</span><br />
|
||
<span class="medgenPMjournal">J Dent Res</span>
|
||
2020 Mar;99(3):241-248.
|
||
doi: 10.1177/0022034520902128.
|
||
<span class="bold">PMID: </span><a href="/pubmed/32077795" target="_blank">32077795</a><a href="/pmc/articles/PMC7036512" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/18820604">Oropharyngeal cancer.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Psyrri A,
|
||
Prezas L,
|
||
Burtness B</span><br />
|
||
<span class="medgenPMjournal">Clin Adv Hematol Oncol</span>
|
||
2008 Aug;6(8):604-12.
|
||
<span class="bold">PMID: </span><a href="/pubmed/18820604" target="_blank">18820604</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Oropharyngeal%20squamous%20cell%20carcinoma%22%20AND%20Diagnosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (969)</a></div><h3 class="subhead">Therapy</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/38857913">Single-cell analysis reveals cellular and molecular factors counteracting HPV-positive oropharyngeal cancer immunotherapy outcomes.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Cha J,
|
||
Kim DH,
|
||
Kim G,
|
||
Cho JW,
|
||
Sung E,
|
||
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2019 Feb;19(2):105-119.
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<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Oropharyngeal%20squamous%20cell%20carcinoma%22%20AND%20Clinical%20prediction%20guides%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (968)</a></div></div>
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<div class="portlet mgSection" id="ID_104">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_systematic_reviews">Recent systematic reviews</h1><a sid="104" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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Macluskey M,
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||
Epub 2017 Feb 24
|
||
doi: 10.1016/j.jormas.2017.02.004.
|
||
<span class="bold">PMID: </span><a href="/pubmed/28345518" target="_blank">28345518</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Oropharyngeal%20squamous%20cell%20carcinoma%22%20AND%20systematic%5Bsb%5D%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (86)</a></div></div>
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