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<meta name="keywords" content="C0239941, elevated fetal hemoglobin, finding, hemoglobin f increased, increased fetal hemoglobin, increased haemoglobin f, increased hemoglobin f, persistence of haemoglobin f, persistence of hbf, persistence of hemoglobin f, autosomal dominant, autosomal recessive, birth defects, chromosomal disease, chromosome, clinical features, clinical findings, clinical genetics, clinical recommendations, clinvar, congenital chromosomal disease, consumer genetic resources, cytogenetic location, disease characteristics, disease definitions, disease descriptions, disease ontology, disease synonyms, disease vocabulary, dysmorphology, entrez, familial disease, gene, gene-disease relationship, genereviews, genetic disease, genetic disorder, genetic terminology, genetic testing registry, genetics home reference, genomic disease, gtr, hereditary disease, heritable disease, hpo, human phenotype ontology, inherited disease, management guidelines, maternal inheritance, medgen, medical genetics, medical subject headings, mesh, mitochondrial inheritance, mode of inheritance, national center for biotechnology information, national institutes of health, national library of medicine, ncbi, nih, nlm, omim, ordo, orphanet, paternal inheritance, phenome, position statements, professional practice guidelines, rare disease, reference sequence, refseq, snomed ct, syndrome, undiagnosed diseases, x-linked recessive" /><meta name="description" content="Hemoglobin F (HbF) contains two globin alpha chains and two globin gamma chains. It is the main form of hemoglobin in the fetus during the last seven months of intrauterine development and in the half year of postnatal life. In adults it normally makes up less than one percent of all hemoglobin. This term refers to an increase in HbF above this limit. In beta thalassemia major, it may represent over 90 percent of all hemoglobin, and in beta thalassemia minor it may make up between 0.5 to 4 percent." /><meta name="robots" content="index,nofollow,noarchive" />
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<!--
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||
UID=68693
|
||
ConceptID=C0239941
|
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-->
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<!--imgCountBooks = 0--><h1 class="medgenTitle"><div class="MedGenTitleText">Persistence of hemoglobin F</div></h1><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>68693</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0239941</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Finding</dd></dl></div></div><table class="medgenTable"><tbody><tr><td>Synonyms:</td>
|
||
<td>Elevated fetal hemoglobin; Increased fetal hemoglobin; Increased hemoglobin F</td></tr>
|
||
<tr><td colspan="2" class="small"> </td></tr><tr><td>HPO:</td>
|
||
<td><a target="_blank" title="Human Phenotype Ontology" href="https://hpo.jax.org/app/browse/term/HP:0011904">HP:0011904</a></td></tr>
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Definition">Definition</h1><a sid="100" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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||
<div class="portlet_content ln">Hemoglobin F (HbF) contains two globin alpha chains and two globin gamma chains. It is the main form of hemoglobin in the fetus during the last seven months of intrauterine development and in the half year of postnatal life. In adults it normally makes up less than one percent of all hemoglobin. This term refers to an increase in HbF above this limit. In beta thalassemia major, it may represent over 90 percent of all hemoglobin, and in beta thalassemia minor it may make up between 0.5 to 4 percent. [from <a title="Human Phenotype Ontology" href="http://www.human-phenotype-ontology.org" class="defSource" target="_blank">HPO</a>]</div>
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<div class="portlet_content ln HierarchyGTR"><div class="jig-ncbitabs"><ul><li><a href="#tabGTR">GTR</a></li><li><a href="#tabMGEN">MeSH</a></li></ul><div id="tabGTR"><div class="search_result"><div class="rprts"><div class="chiclet_legend"><span class="chiclet_list" style="position:static;"><span title="Clinical test" class="chiclet Ccolor round">C</span><span>Clinical test, </span><span title="Research test" class="chiclet Rcolor round">R</span><span>Research test, </span><span title="OMIM" class="chiclet Ocolor ">O</span><span>OMIM, </span><span title="GeneReview" class="chiclet Gcolor">G</span><span><em>GeneReviews</em>, </span><span title="ClinVar" class="chiclet Vcolor">V</span><span>ClinVar </span></span></div><div id="hierarchy" class="margin_t1"><div class="ds_tree"><ul><li class="matched_ds"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C0239941[DISCUI]&test_type=Clinical&redirect=true" ref="ncbi_uid=68693">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet unavailable" title="OMIM">O</span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&from_uid=68693" ref="ncbi_uid=68693">V</a></span></span><span class="TLline">Persistence of hemoglobin F</span></li></ul></div></div></div></div></div><div id="tabMGEN"><div class="ds_tree"><ul><li><span class="TLline"><a href="/medgen/867443" ref="tree=MeSH" title="MedGen record for Phenotypic abnormality">Phenotypic abnormality</a></span><ul><li><span class="TLline"><a href="/medgen/163092" ref="tree=MeSH" title="MedGen record for Abnormality of blood and blood-forming tissues">Abnormality of blood and blood-forming tissues</a></span><ul><li><span class="TLline"><a href="/medgen/488883" ref="tree=MeSH" title="MedGen record for Abnormal erythrocyte morphology">Abnormal erythrocyte morphology</a></span><ul><li><span class="TLline"><a href="/medgen/776552" ref="tree=MeSH" title="MedGen record for Abnormal hemoglobin">Abnormal hemoglobin</a></span><ul><li><span class="matched_ds">Persistence of hemoglobin F</span></li></ul></li></ul></li></ul></li></ul></li></ul></div></div></div></div>
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</div>
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<div class="portlet mgSection" id="ID_112">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Conditions_with_this_feature">Conditions with this feature</h1><a sid="112" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="portlet_content ln clinfeat">
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||
<div class="divPopper rprt" id="rdis_5495"><div><strong>Hereditary persistence of fetal hemoglobin</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>5495</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0019025</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">The persistence of substantial fetal hemoglobin production into adulthood, usually associated with hemoglobinopathies due to mutations in the alpha and/or beta chain of hemoglobin.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/5495">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_387892"><div><strong>Diamond-Blackfan anemia 3</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>387892</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1857719</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Diamond-Blackfan anemia (DBA) is characterized by a profound normochromic and usually macrocytic anemia with normal leukocytes and platelets, congenital malformations in up to 50%, and growth deficiency in 30% of affected individuals. The hematologic complications occur in 90% of affected individuals during the first year of life. The phenotypic spectrum ranges from a mild form (e.g., mild anemia or no anemia with only subtle erythroid abnormalities, physical malformations without anemia) to a severe form of fetal anemia resulting in nonimmune hydrops fetalis. DBA is associated with an increased risk for acute myelogenous leukemia (AML), myelodysplastic syndrome (MDS), and solid tumors including osteogenic sarcoma.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/387892">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_347036"><div><strong>Dominant beta-thalassemia</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>347036</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1858990</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Dominantly inherited inclusion body beta-thalassemia is characterized by the presence of inclusion bodies in red blood cell precursors, moderately severe anemia, jaundice, and splenomegaly (summary by Ropero et al., 2005).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/347036">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_390966"><div><strong>Diamond-Blackfan anemia 1</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>390966</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C2676137</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Diamond-Blackfan anemia (DBA) is characterized by a profound normochromic and usually macrocytic anemia with normal leukocytes and platelets, congenital malformations in up to 50%, and growth deficiency in 30% of affected individuals. The hematologic complications occur in 90% of affected individuals during the first year of life. The phenotypic spectrum ranges from a mild form (e.g., mild anemia or no anemia with only subtle erythroid abnormalities, physical malformations without anemia) to a severe form of fetal anemia resulting in nonimmune hydrops fetalis. DBA is associated with an increased risk for acute myelogenous leukemia (AML), myelodysplastic syndrome (MDS), and solid tumors including osteogenic sarcoma.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/390966">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_419918"><div><strong>Diamond-Blackfan anemia 6</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>419918</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C2931850</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Diamond-Blackfan anemia (DBA) is characterized by a profound normochromic and usually macrocytic anemia with normal leukocytes and platelets, congenital malformations in up to 50%, and growth deficiency in 30% of affected individuals. The hematologic complications occur in 90% of affected individuals during the first year of life. The phenotypic spectrum ranges from a mild form (e.g., mild anemia or no anemia with only subtle erythroid abnormalities, physical malformations without anemia) to a severe form of fetal anemia resulting in nonimmune hydrops fetalis. DBA is associated with an increased risk for acute myelogenous leukemia (AML), myelodysplastic syndrome (MDS), and solid tumors including osteogenic sarcoma.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/419918">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_462276"><div><strong>Congenital dyserythropoietic anemia type 4</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>462276</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C3150926</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Congenital dyserythropoietic anemia type IVa (CDAN4A) is an autosomal dominant red blood cell disorder characterized by ineffective erythropoiesis and hemolysis resulting in anemia. Circulating erythroblasts and erythroblasts in the bone marrow show various morphologic abnormalities. Affected individuals with CDAN4A also have increased levels of fetal hemoglobin (summary by Arnaud et al., 2010). For a discussion of genetic heterogeneity of congenital dyserythropoietic anemia, see CDAN1 (224120).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/462276">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_895657"><div><strong>Diamond-Blackfan anemia 14 with mandibulofacial dysostosis</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>895657</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C4225422</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Diamond-Blackfan anemia (DBA) is characterized by a profound normochromic and usually macrocytic anemia with normal leukocytes and platelets, congenital malformations in up to 50%, and growth deficiency in 30% of affected individuals. The hematologic complications occur in 90% of affected individuals during the first year of life. The phenotypic spectrum ranges from a mild form (e.g., mild anemia or no anemia with only subtle erythroid abnormalities, physical malformations without anemia) to a severe form of fetal anemia resulting in nonimmune hydrops fetalis. DBA is associated with an increased risk for acute myelogenous leukemia (AML), myelodysplastic syndrome (MDS), and solid tumors including osteogenic sarcoma.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/895657">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_934711"><div><strong>Bone marrow failure syndrome 3</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>934711</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C4310744</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Bone marrow failure syndrome-3 is an autosomal recessive disorder characterized by onset of pancytopenia in early childhood. Patients may have additional variable nonspecific somatic abnormalities, including poor growth, microcephaly, and skin anomalies (summary by Tummala et al., 2016). BMFS3 has a distinct phenotype and may include features that overlap with Shwachman-Diamond syndrome (SDS1; 260400), such as pancreatic insufficiency and short stature, and with dyskeratosis congenita (see, e.g., DKCA1, 127550), such as dental and hair abnormalities and shortened telomeres. In addition, some patients may have joint and skeletal abnormalities, impaired development, and retinal dysplasia (summary by D'Amours et al., 2018). For a discussion of genetic heterogeneity of BMFS, see BMFS1 (614675).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/934711">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_934800"><div><strong>Dias-Logan syndrome</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>934800</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C4310833</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">BCL11A-related intellectual disability (BCL11A-ID) is characterized by developmental delay / intellectual disability of variable degree, neonatal hypotonia, microcephaly, distinctive but variable facial characteristics, behavior problems, and asymptomatic persistence of fetal hemoglobin. Growth delay, seizures, and autism spectrum disorder have also been reported in some affected individuals.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/934800">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_1640046"><div><strong>Shwachman-Diamond syndrome 1</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1640046</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C4692625</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Shwachman-Diamond syndrome (SDS) is characterized by exocrine pancreatic dysfunction with malabsorption, malnutrition, and growth failure; hematologic abnormalities with single- or multilineage cytopenias and susceptibility to myelodysplastic syndrome (MDS) and acute myelogenous leukemia (AML); and bone abnormalities. In almost all affected children, persistent or intermittent neutropenia is an early finding. Short stature and recurrent infections are common.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1640046">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_1717739"><div><strong>Bone marrow failure syndrome 6</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1717739</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C5394274</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Bone marrow failure syndrome-6 (BMFS6) is an autosomal dominant disorder characterized by variable features of hypocellular bone marrow, anemia, neutropenia, lymphopenia, and increased incidence of cancer (Toufektchan et al., 2020). For a discussion of genetic heterogeneity of BMFS, see BMFS1 (614675).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1717739">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_1802903"><div><strong>Macrocephaly, neurodevelopmental delay, lymphoid hyperplasia, and persistent fetal hemoglobin</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1802903</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C5676928</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Macrocephaly, neurodevelopmental delay, lymphoid hyperplasia, and persistent fetal hemoglobin (MNDLFH) is characterized by clinically significant pharyngeal lymphoid hypertrophy, with adenoid overgrowth, frequent upper airway infections, and sleep apnea. Macrocephaly without structural brain abnormalities is present, and patients exhibit increased weight for height as well as delayed gross motor and impaired intellectual development; autistic features and attention-deficit hyperactivity disorder have also been reported. An increased fraction of fetal hemoglobin has been observed in some patients (Ohishi et al., 2020; von der Lippe et al., 2022).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1802903">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_1844409"><div><strong>Ziegler-Huang syndrome</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1844409</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C5882688</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Ziegler-Huang syndrome (ZHS) is a bone marrow failure syndrome characterized by severe growth retardation responsive to growth hormone (GH1; 139250) treatment, testicular hypoplasia, and progressive bone marrow failure, with thrombocytopenia and macrocytosis developing in childhood (Huang et al., 2023). For a general phenotypic description and discussion of genetic heterogeneity of bone marrow failure syndromes, see BMFS1 (614675).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1844409">Condition Record</a></div></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_934711" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Bone marrow failure syndrome 3</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1717739" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Bone marrow failure syndrome 6</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_462276" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Congenital dyserythropoietic anemia type 4</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_390966" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Diamond-Blackfan anemia 1</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_895657" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Diamond-Blackfan anemia 14 with mandibulofacial dysostosis</a></div><div class="jig-moreless" data-jigconfig="class: 'moveDown', moreText: 'See full list (13)', lessText: 'Show less', nodeBefore: 0"><span id="clinMore">
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_387892" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Diamond-Blackfan anemia 3</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_419918" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Diamond-Blackfan anemia 6</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_934800" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Dias-Logan syndrome</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_347036" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Dominant beta-thalassemia</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_5495" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Hereditary persistence of fetal hemoglobin</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1802903" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Macrocephaly, neurodevelopmental delay, lymphoid hyperplasia, and persistent fetal hemoglobin</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1640046" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Shwachman-Diamond syndrome 1</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1844409" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Ziegler-Huang syndrome</a></div></span></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_105">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Professional_guidelines">Professional guidelines</h1><a sid="105" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">PubMed<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpPM"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/39448799">BCL11A intellectual developmental disorder: defining the clinical spectrum and genotype-phenotype correlations.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Peron A,
|
||
D'Arco F,
|
||
Aldinger KA,
|
||
Smith-Hicks C,
|
||
Zweier C,
|
||
Gradek GA,
|
||
Bradbury K,
|
||
Accogli A,
|
||
Andersen EF,
|
||
Au PYB,
|
||
Battini R,
|
||
Beleford D,
|
||
Bird LM,
|
||
Bouman A,
|
||
Bruel AL,
|
||
Busk ØL,
|
||
Campeau PM,
|
||
Capra V,
|
||
Carlston C,
|
||
Carmichael J,
|
||
Chassevent A,
|
||
Clayton-Smith J,
|
||
Bamshad MJ,
|
||
Earl DL,
|
||
Faivre L,
|
||
Philippe C,
|
||
Ferreira P,
|
||
Graul-Neumann L,
|
||
Green MJ,
|
||
Haffner D,
|
||
Haldipur P,
|
||
Hanna S,
|
||
Houge G,
|
||
Jones WD,
|
||
Kraus C,
|
||
Kristiansen BE,
|
||
Lespinasse J,
|
||
Low KJ,
|
||
Lynch SA,
|
||
Maia S,
|
||
Mao R,
|
||
Kalinauskiene R,
|
||
Melver C,
|
||
McDonald K,
|
||
Montgomery T,
|
||
Morleo M,
|
||
Motter C,
|
||
Openshaw AS,
|
||
Palumbos JC,
|
||
Parikh AS,
|
||
Perilla-Young Y,
|
||
Powell CM,
|
||
Person R,
|
||
Desai M,
|
||
Piard J,
|
||
Pfundt R,
|
||
Scala M,
|
||
Serey-Gaut M,
|
||
Shears D,
|
||
Slavotinek A,
|
||
Suri M,
|
||
Turner C,
|
||
Tvrdik T,
|
||
Weiss K,
|
||
Wentzensen IM,
|
||
Zollino M,
|
||
Hsieh TC;
|
||
C4RCD Research Group;
|
||
Telethon Undiagnosed Disease Program (TUDP);
|
||
University of Washington Center for Mendelian Genomics (UW-CMG),
|
||
de Vries BBA,
|
||
Guillemot F,
|
||
Dobyns WB,
|
||
Viskochil D,
|
||
Dias C</span><br />
|
||
<span class="medgenPMjournal">Eur J Hum Genet</span>
|
||
2025 Mar;33(3):312-324.
|
||
Epub 2024 Oct 24
|
||
doi: 10.1038/s41431-024-01701-z.
|
||
<span class="bold">PMID: </span><a href="/pubmed/39448799" target="_blank">39448799</a><a href="/pmc/articles/PMC11893779" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/34192341">Diagnosis and Management of Gestational Diabetes Mellitus: An Overview of National and International Guidelines.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Tsakiridis I,
|
||
Giouleka S,
|
||
Mamopoulos A,
|
||
Kourtis A,
|
||
Athanasiadis A,
|
||
Filopoulou D,
|
||
Dagklis T</span><br />
|
||
<span class="medgenPMjournal">Obstet Gynecol Surv</span>
|
||
2021 Jun;76(6):367-381.
|
||
doi: 10.1097/OGX.0000000000000899.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34192341" target="_blank">34192341</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/28870138">A Plea for the Newborn Diagnosis of Hb S-Hereditary Persistence of Fetal Hemoglobin.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Serjeant GR,
|
||
Serjeant BE,
|
||
Hambleton IR,
|
||
Oakley M,
|
||
Thein SL,
|
||
Clark B</span><br />
|
||
<span class="medgenPMjournal">Hemoglobin</span>
|
||
2017 May;41(3):216-217.
|
||
Epub 2017 Sep 5
|
||
doi: 10.1080/03630269.2017.1360336.
|
||
<span class="bold">PMID: </span><a href="/pubmed/28870138" target="_blank">28870138</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(persistence%20of%20hemoglobin%20f)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">See all (25)</a></div></div>
|
||
</div>
|
||
<div class="display-none help-popup" id="guidelinesHelpPM">These guidelines are articles in PubMed that match specific search criteria developed by MedGen to capture the most relevant practice guidelines. This list may not be comprehensive and may include broader topics as well. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div><div class="display-none help-popup" id="guidelinesHelpCurated">These guidelines are manually curated by the MedGen team
|
||
to supplement articles available in PubMed. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div>
|
||
<div class="portlet mgSection" id="ID_103">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_clinical_studies">Recent clinical studies</h1><a sid="103" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">Etiology</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/34192341">Diagnosis and Management of Gestational Diabetes Mellitus: An Overview of National and International Guidelines.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Tsakiridis I,
|
||
Giouleka S,
|
||
Mamopoulos A,
|
||
Kourtis A,
|
||
Athanasiadis A,
|
||
Filopoulou D,
|
||
Dagklis T</span><br />
|
||
<span class="medgenPMjournal">Obstet Gynecol Surv</span>
|
||
2021 Jun;76(6):367-381.
|
||
doi: 10.1097/OGX.0000000000000899.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34192341" target="_blank">34192341</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/33734896">Molecular and Hematological Analysis of Alpha- and Beta-Thalassemia in a Cohort of Mexican Patients.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Rizo-de la Torre LDC,
|
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Rentería-López VM,
|
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Sánchez-López JY,
|
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Magaña-Torres MT,
|
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Ibarra-Cortés B,
|
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Perea-Díaz FJ</span><br />
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|
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<div class="nl"><a target="_blank" href="/pubmed/32184147">Iron deficiency in pregnancy.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Georgieff MK</span><br />
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<span class="bold">PMID: </span><a href="/pubmed/32184147" target="_blank">32184147</a><a href="/pmc/articles/PMC7492370" target="_blank" class="PubMedFree">Free PMC Article</a></div>
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<div class="nl"><a target="_blank" href="/pubmed/93487">Hereditary persistence of fetal haemoglobin (HPFH) and delta beta thalassaemia.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Wood WG,
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<div class="nl"><a target="_blank" href="/pubmed/5682897">A case of multople chromosomal rearrangements with persistence of foetal haemoglobin.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Nuzzo F,
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Marini A,
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<div class="nl"><a target="_blank" href="/pubmed/38084559">Compound heterozygous beta thalassaemia and hereditary persistence of foetal haemoglobin presenting as thalassemia intermedia.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Tsakiridis I,
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<div class="nl"><a target="_blank" href="/pubmed/32184147">Iron deficiency in pregnancy.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Georgieff MK</span><br />
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<span class="medgenPMjournal">Am J Obstet Gynecol</span>
|
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2020 Oct;223(4):516-524.
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Epub 2020 Mar 14
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doi: 10.1016/j.ajog.2020.03.006.
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<span class="bold">PMID: </span><a href="/pubmed/32184147" target="_blank">32184147</a><a href="/pmc/articles/PMC7492370" target="_blank" class="PubMedFree">Free PMC Article</a></div>
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<div class="nl"><a target="_blank" href="/pubmed/28870138">A Plea for the Newborn Diagnosis of Hb S-Hereditary Persistence of Fetal Hemoglobin.</a></div>
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<span class="bold">PMID: </span><a href="/pubmed/28870138" target="_blank">28870138</a></div>
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<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Persistence%20of%20hemoglobin%20F%22%20AND%20Diagnosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (169)</a></div><h3 class="subhead">Therapy</h3>
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<div class="nl"><a target="_blank" href="/pubmed/35843392">Hydroxyurea Decouples Persistent F-Cell Elevation and Induction of γ-Globin.</a></div>
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<span class="bold">PMID: </span><a href="/pubmed/35843392" target="_blank">35843392</a></div>
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<div class="nl"><a target="_blank" href="/pubmed/32892201">The Genetic and Clinical Significance of Fetal Hemoglobin Expression in Sickle Cell Disease.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Adekile A</span><br />
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<span class="medgenPMjournal">Med Princ Pract</span>
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Epub 2020 Sep 4
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<span class="bold">PMID: </span><a href="/pubmed/32892201" target="_blank">32892201</a><a href="/pmc/articles/PMC8280415" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/32184147">Iron deficiency in pregnancy.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Georgieff MK</span><br />
|
||
<span class="medgenPMjournal">Am J Obstet Gynecol</span>
|
||
2020 Oct;223(4):516-524.
|
||
Epub 2020 Mar 14
|
||
doi: 10.1016/j.ajog.2020.03.006.
|
||
<span class="bold">PMID: </span><a href="/pubmed/32184147" target="_blank">32184147</a><a href="/pmc/articles/PMC7492370" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/30287096">Wake-up Sleepy Gene: Reactivating Fetal Globin for β-Hemoglobinopathies.</a></div>
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Martyn GE,
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Funnell APW,
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<span class="bold">PMID: </span><a href="/pubmed/30287096" target="_blank">30287096</a></div>
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<div class="nl"><a target="_blank" href="/pubmed/773132">Congenital hypoplastic anemia.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Diamond LK,
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<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Persistence%20of%20hemoglobin%20F%22%20AND%20Therapy%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (71)</a></div><h3 class="subhead">Prognosis</h3>
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<div class="nl"><a target="_blank" href="/pubmed/28689691">Variability of homozygous sickle cell disease: The role of alpha and beta globin chain variation and other factors.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Serjeant GR,
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<div class="portlet_content ln"><span class="medgenPMauthor">Saraf SL,
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Molokie RE,
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Nouraie M,
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Sable CA,
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Luchtman-Jones L,
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Ensing GJ,
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Campbell AD,
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Rana SR,
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Niu XM,
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Machado RF,
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Gladwin MT,
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|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/9668525">Molecular basis of hereditary persistence of fetal hemoglobin.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Forget BG</span><br />
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<div class="nl"><a target="_blank" href="/pubmed/9371979">Natural history and determinants of clinical severity of sickle cell disease.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Serjeant GR</span><br />
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<div class="nl"><a target="_blank" href="/pubmed/773132">Congenital hypoplastic anemia.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Diamond LK,
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Wang WC,
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Alter BP</span><br />
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<span class="medgenPMjournal">Adv Pediatr</span>
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<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Persistence%20of%20hemoglobin%20F%22%20AND%20Prognosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (80)</a></div><h3 class="subhead">Clinical prediction guides</h3>
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<div class="nl"><a target="_blank" href="/pubmed/33734896">Molecular and Hematological Analysis of Alpha- and Beta-Thalassemia in a Cohort of Mexican Patients.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Rizo-de la Torre LDC,
|
||
Rentería-López VM,
|
||
Sánchez-López JY,
|
||
Magaña-Torres MT,
|
||
Ibarra-Cortés B,
|
||
Perea-Díaz FJ</span><br />
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<span class="medgenPMjournal">Genet Test Mol Biomarkers</span>
|
||
2021 Mar;25(3):247-252.
|
||
doi: 10.1089/gtmb.2020.0276.
|
||
<span class="bold">PMID: </span><a href="/pubmed/33734896" target="_blank">33734896</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/28689691">Variability of homozygous sickle cell disease: The role of alpha and beta globin chain variation and other factors.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Serjeant GR,
|
||
Vichinsky E</span><br />
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<span class="medgenPMjournal">Blood Cells Mol Dis</span>
|
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2018 May;70:66-77.
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||
Epub 2017 Jun 21
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||
doi: 10.1016/j.bcmd.2017.06.004.
|
||
<span class="bold">PMID: </span><a href="/pubmed/28689691" target="_blank">28689691</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/24361300">Differences in the clinical and genotypic presentation of sickle cell disease around the world.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Saraf SL,
|
||
Molokie RE,
|
||
Nouraie M,
|
||
Sable CA,
|
||
Luchtman-Jones L,
|
||
Ensing GJ,
|
||
Campbell AD,
|
||
Rana SR,
|
||
Niu XM,
|
||
Machado RF,
|
||
Gladwin MT,
|
||
Gordeuk VR</span><br />
|
||
<span class="medgenPMjournal">Paediatr Respir Rev</span>
|
||
2014 Mar;15(1):4-12.
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Epub 2013 Nov 15
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||
doi: 10.1016/j.prrv.2013.11.003.
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<span class="bold">PMID: </span><a href="/pubmed/24361300" target="_blank">24361300</a><a href="/pmc/articles/PMC3944316" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/2454217">Genetic heterogeneity of thalassemias in Mexican mestizo patients with hemolytic anemia.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Ibarra B,
|
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Vaca G,
|
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de la Mora E,
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||
Romero F,
|
||
Aguilar-Luna C,
|
||
Mejía A,
|
||
Esparza MA,
|
||
Pérez G,
|
||
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<span class="medgenPMjournal">Hum Hered</span>
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1988;38(2):95-100.
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||
doi: 10.1159/000153765.
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<span class="bold">PMID: </span><a href="/pubmed/2454217" target="_blank">2454217</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/6166591">The first homozygote for the hereditary persistence of fetal hemoglobin observed in the southeastern United States.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Huisman TH</span><br />
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<span class="medgenPMjournal">Hemoglobin</span>
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|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Persistence%20of%20hemoglobin%20F%22%20AND%20Clinical%20prediction%20guides%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (162)</a></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_104">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_systematic_reviews">Recent systematic reviews</h1><a sid="104" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln">
|
||
<div class="nl"><a target="_blank" href="/pubmed/30783211">A systematic literature review of the relation between iron status/anemia in pregnancy and offspring neurodevelopment.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Janbek J,
|
||
Sarki M,
|
||
Specht IO,
|
||
Heitmann BL</span><br />
|
||
<span class="medgenPMjournal">Eur J Clin Nutr</span>
|
||
2019 Dec;73(12):1561-1578.
|
||
Epub 2019 Feb 19
|
||
doi: 10.1038/s41430-019-0400-6.
|
||
<span class="bold">PMID: </span><a href="/pubmed/30783211" target="_blank">30783211</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Persistence%20of%20hemoglobin%20F%22%20AND%20systematic%5Bsb%5D%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (1)</a></div></div>
|
||
</div>
|
||
</div></div></div></div></div></div></div>
|
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|
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|
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|
||
<div class="supplemental col three_col last">
|
||
<h2 class="offscreen_noflow">Supplemental Content</h2>
|
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|
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|
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|
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<div class="portlet mgSection" id="ID_113">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Table_of_contents">Table of contents</h1><a sid="113" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="portlet_content ln"><ul><li><a href="/gtr/tests?term=C0239941%5bDISCUI%5d&filter=method%3A2%5F19" target="_blank">Targeted variant analysis (1)</a></li>
|
||
<li class="portletSeeAll portletSeeAllPad"><total><a href="/gtr/tests?term=C0239941%5bDISCUI%5d" target="_blank">See all (1)</a></total></li>
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|
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Clinical_resources">Clinical resources</h1><a sid="119" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="portlet_content ln"><ul><li><a href="https://clinicaltrials.gov/search?cond=Persistence%20of%20hemoglobin%20F" target="_blank">ClinicalTrials.gov</a></li></ul></div>
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