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<meta name="keywords" content="C0235988, decreased circulating iron concentration, decreased serum iron, finding, hypoferremia, low serum iron, serum iron below reference range, serum iron low, autosomal dominant, autosomal recessive, birth defects, chromosomal disease, chromosome, clinical features, clinical findings, clinical genetics, clinical recommendations, clinvar, congenital chromosomal disease, consumer genetic resources, cytogenetic location, disease characteristics, disease definitions, disease descriptions, disease ontology, disease synonyms, disease vocabulary, dysmorphology, entrez, familial disease, gene, gene-disease relationship, genereviews, genetic disease, genetic disorder, genetic terminology, genetic testing registry, genetics home reference, genomic disease, gtr, hereditary disease, heritable disease, hpo, human phenotype ontology, inherited disease, management guidelines, maternal inheritance, medgen, medical genetics, medical subject headings, mesh, mitochondrial inheritance, mode of inheritance, national center for biotechnology information, national institutes of health, national library of medicine, ncbi, nih, nlm, omim, ordo, orphanet, paternal inheritance, phenome, position statements, professional practice guidelines, rare disease, reference sequence, refseq, snomed ct, syndrome, undiagnosed diseases, x-linked recessive" /><meta name="description" content="The concentration of iron in the blood circulation is below the lower limit of normal." /><meta name="robots" content="index,nofollow,noarchive" />
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<title>Decreased circulating iron concentration (Concept Id: C0235988)
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<!--
UID=65918
ConceptID=C0235988
-->
<!--imgCountBooks = 0--><h1 class="medgenTitle"><div class="MedGenTitleText">Decreased circulating iron concentration</div></h1><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>65918</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C0235988</a></dd><dt><span class="dotprefix"></span></dt><dd>Finding</dd></dl></div></div><table class="medgenTable"><tbody><tr><td>Synonyms:</td>
<td>Decreased serum iron; Low serum iron</td></tr>
<tr><td><span class="bold">SNOMED CT: </span></td>
<td>Serum iron low (165623008); Serum iron below reference range (165623008)</td></tr>
<tr><td colspan="2" class="small"> </td></tr><tr><td>HPO:</td>
<td><a target="_blank" title="Human Phenotype Ontology" href="https://hpo.jax.org/app/browse/term/HP:0040303">HP:0040303</a></td></tr>
</tbody></table></div><div class="rprt-body jig-ncbiinpagenav" data-jigconfig="smoothScroll: false, gotoTopLink: true, gotoTopLinkText: '', gotoTopLinkAttrs: {'title': 'Go to the top of the page'},allHeadingLevels: ['h1'], topOfPageTOC: true, tocId: 'my-toc'"><div id="rprt-tabs-1" class="rprt-tab"><div id="tb-termsProp-1"><div class="leftCol mgCol"><div>
<div class="portlet mgSection" id="ID_100">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Definition">Definition</h1><a sid="100" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln">The concentration of iron in the blood circulation is below the lower limit of normal. [from <a title="Human Phenotype Ontology" href="http://www.human-phenotype-ontology.org" class="defSource" target="_blank">HPO</a>]</div>
</div>
<div class="portlet mgSection" id="ID_118">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Term_Hierarchy">Term Hierarchy</h1><a sid="118" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln HierarchyGTR"><div class="jig-ncbitabs"><ul><li><a href="#tabGTR">GTR</a></li><li><a href="#tabMGEN">MeSH</a></li></ul><div id="tabGTR"><div class="search_result"><div class="rprts"><div class="chiclet_legend"><span class="chiclet_list" style="position:static;"><span title="Clinical test" class="chiclet Ccolor round">C</span><span>Clinical test,  </span><span title="Research test" class="chiclet Rcolor round">R</span><span>Research test,  </span><span title="OMIM" class="chiclet Ocolor ">O</span><span>OMIM,  </span><span title="GeneReview" class="chiclet Gcolor">G</span><span><em>GeneReviews</em>,  </span><span title="ClinVar" class="chiclet Vcolor">V</span><span>ClinVar  </span></span></div><div id="hierarchy" class="margin_t1"><div class="ds_tree"><ul><li class="matched_ds"><span class="chiclet_list"><span class="chiclet unavailable round" title="Clinical test">C</span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet unavailable" title="OMIM">O</span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet unavailable" title="ClinVar">V</span></span><span class="TLline">Decreased circulating iron concentration</span></li></ul></div></div></div></div></div><div id="tabMGEN"><div class="ds_tree"><ul><li><span class="TLline"><a href="/medgen/1701080" ref="tree=MeSH" title="MedGen record for Abnormal circulating metabolite concentration">Abnormal circulating metabolite concentration</a></span><ul><li><span class="TLline"><a href="/medgen/312393" ref="tree=MeSH" title="MedGen record for Abnormal blood ion concentration">Abnormal blood ion concentration</a></span><ul><li><span class="TLline"><a href="/medgen/869223" ref="tree=MeSH" title="MedGen record for Abnormal blood cation concentration">Abnormal blood cation concentration</a></span><ul><li><span class="TLline"><a href="/medgen/869164" ref="tree=MeSH" title="MedGen record for Abnormal blood transition element cation concentration">Abnormal blood transition element cation concentration</a></span><ul><li><span class="TLline"><a href="/medgen/869163" ref="tree=MeSH" title="MedGen record for Abnormality of iron homeostasis">Abnormality of iron homeostasis</a></span><ul><li><span class="TLline"><a href="/medgen/808235" ref="tree=MeSH" title="MedGen record for Abnormal circulating iron concentration">Abnormal circulating iron concentration</a></span><ul><li><span class="matched_ds">Decreased circulating iron concentration</span></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></div></div></div></div>
</div>
<div class="portlet mgSection" id="ID_112">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Conditions_with_this_feature">Conditions with this feature</h1><a sid="112" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln clinfeat">
<div class="divPopper rprt" id="rdis_168057"><div><strong>Deficiency of ferroxidase</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>168057</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information."><span class="highlight" style="background-color:">C0878682</span></a></dd><dt><span class="dotprefix"></span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
<div class="spaceAbove">Aceruloplasminemia is characterized by iron accumulation in the brain and viscera. The clinical triad of retinal degeneration, diabetes mellitus (DM), and neurologic disease is seen in individuals ranging from age 30 years to older than 70 years. The neurologic findings of movement disorder (blepharospasm, grimacing, facial and neck dystonia, tremors, chorea) and ataxia (gait ataxia, dysarthria) correspond to regions of iron deposition in the brain. Individuals with aceruloplasminemia often present with anemia prior to onset of DM or obvious neurologic problems. Cognitive dysfunction including apathy and forgetfulness occurs in more than half of individuals with this condition.</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/168057">Condition Record</a></div></div>
<div class="divPopper rprt" id="rdis_347128"><div><strong>Predisposition to invasive fungal disease due to CARD9 deficiency</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>347128</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C1859353</a></dd><dt><span class="dotprefix"></span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
<div class="spaceAbove">A rare genetic primary immunodeficiency with characteristics of increased susceptibility to fungal infections that typically manifest as recurrent, chronic mucocutaneous candidiasis, systemic candidiasis with meningoencephalitis and deep dermatophytosis. Dermatophytes invade skin, hair, nails, lymph nodes and brain, resulting in erythematosquamous lesions, nodular subcutaneous or ulcerative infiltrations, severe onychomycosis and lymphadenopathy.</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/347128">Condition Record</a></div></div>
<div class="divPopper rprt" id="rdis_482919"><div><strong>Trichohepatoenteric syndrome 2</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>482919</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C3281289</a></dd><dt><span class="dotprefix"></span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
<div class="spaceAbove">Trichohepatoenteric syndrome (THES), generally considered to be a neonatal enteropathy, is characterized by intractable diarrhea (seen in almost all affected children), woolly hair (seen in all), intrauterine growth restriction, facial dysmorphism, and short stature. Additional findings include poorly characterized immunodeficiency, recurrent infections, skin abnormalities, and liver disease. Mild intellectual disability (ID) is seen in about 50% of affected individuals. Less common findings include congenital heart defects and platelet anomalies. To date 52 affected individuals have been reported.</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/482919">Condition Record</a></div></div>
<div class="divPopper rprt" id="rdis_934743"><div><strong>Retinitis pigmentosa and erythrocytic microcytosis</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>934743</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C4310776</a></dd><dt><span class="dotprefix"></span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
<div class="spaceAbove">TRNT1 deficiency encompasses what was first thought to be two separate disorders, a severe disorder called sideroblastic anemia with B-cell immunodeficiency, periodic fevers, and developmental delay (SIFD) and a milder disorder called retinitis pigmentosa with erythrocytic microcytosis (RPEM), each named for its most common features. SIFD begins in infancy, and affected individuals usually do not survive past childhood. RPEM, on the other hand, is recognized in early adulthood, and the microcytosis usually does not cause any health problems. However, it has since been recognized that some individuals have a combination of features that fall between these two ends of the severity spectrum. All of these cases are now considered part of TRNT1 deficiency.\n\nEye abnormalities, often involving the light-sensing tissue at the back of the eye (the retina), can occur in people with TRNT1 deficiency. Some of these individuals have a condition called retinitis pigmentosa, in which the light-sensing cells of the retina gradually deteriorate. Eye problems in TRNT1 deficiency can lead to vision loss.\n\nIn addition, many individuals with TRNT1 deficiency have recurrent fevers that are not caused by an infection. These fever episodes are often one of the earliest recognized symptoms of TRNT1 deficiency, usually beginning in infancy. The fever episodes are typically accompanied by poor feeding, vomiting, and diarrhea, and can lead to hospitalization. In many affected individuals, the episodes occur regularly, arising approximately every 2 to 4 weeks and lasting 5 to 7 days, although the frequency can decrease with age.\n\nMany people with TRNT1 deficiency have an immune system disorder (immunodeficiency) that can lead to recurrent bacterial infections. Repeated infections can cause life-threatening damage to internal organs. The immunodeficiency is characterized by low numbers of immune system cells called B cells, which normally help fight infections by producing immune proteins called antibodies (or immunoglobulins). These proteins target foreign invaders such as bacteria and viruses and mark them for destruction. In many individuals with TRNT1 deficiency, the amount of immunoglobulins is also low (hypogammaglobulinemia).\n\nA common feature of TRNT1 deficiency is a blood condition called sideroblastic anemia, which is characterized by a shortage of red blood cells (anemia). In TRNT1 deficiency, the red blood cells that are present are unusually small (erythrocytic microcytosis). In addition, developing red blood cells in the bone marrow (erythroblasts) can have an abnormal buildup of iron that appears as a ring of blue staining in the cell after treatment in the lab with certain dyes. These abnormal cells are called ring sideroblasts.\n\nFeatures that occur less commonly in people with TRNT1 deficiency include hearing loss caused by abnormalities of the inner ear (sensorineural hearing loss), recurrent seizures (epilepsy), and problems with the kidneys or heart.\n\nNeurological problems are also frequent in TRNT1 deficiency. Many affected individuals have delayed development of speech and motor skills, such as sitting, standing, and walking, and some have low muscle tone (hypotonia).\n\nTRNT1 deficiency is a condition that affects many body systems. Its signs and symptoms can involve blood cells, the immune system, the eyes, and the nervous system. The severity of the signs and symptoms vary widely.</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/934743">Condition Record</a></div></div>
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_168057" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Deficiency of ferroxidase</a></div>
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_347128" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Predisposition to invasive fungal disease due to CARD9 deficiency</a></div>
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_934743" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Retinitis pigmentosa and erythrocytic microcytosis</a></div>
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_482919" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Trichohepatoenteric syndrome 2</a></div></div>
</div>
<div class="portlet mgSection" id="ID_105">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Professional_guidelines">Professional guidelines</h1><a sid="105" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln"><h3 class="subhead">PubMed<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpPM"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3>
<div class="nl"><a target="_blank" href="/pubmed/37164495">Umbilical cord pH, blood gases, and lactate at birth: normal values, interpretation, and clinical utility.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Olofsson P</span><br />
<span class="medgenPMjournal">Am J Obstet Gynecol</span>
2023 May;228(5S):S1222-S1240.
Epub 2023 Mar 19
doi: 10.1016/j.ajog.2022.07.001.
<span class="bold">PMID: </span><a href="/pubmed/37164495" target="_blank">37164495</a></div>
<div class="nl"><a target="_blank" href="/pubmed/30991224">Circulating essential metals and lung cancer: Risk assessment and potential molecular effects.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Bai Y,
Wang G,
Fu W,
Lu Y,
Wei W,
Chen W,
Wu X,
Meng H,
Feng Y,
Liu Y,
Li G,
Wang S,
Wang K,
Dai J,
Li H,
Li M,
Huang J,
Li Y,
Wei S,
Yuan J,
Yao P,
Miao X,
He M,
Zhang X,
Yang H,
Wu T,
Guo H</span><br />
<span class="medgenPMjournal">Environ Int</span>
2019 Jun;127:685-693.
Epub 2019 Apr 13
doi: 10.1016/j.envint.2019.04.021.
<span class="bold">PMID: </span><a href="/pubmed/30991224" target="_blank">30991224</a></div>
<div class="nl"><a target="_blank" href="/pubmed/10869897">Changes in micronutrient concentrations following anti-inflammatory treatment in patients with gastrointestinal cancer.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">McMillan DC,
Sattar N,
Talwar D,
O'Reilly DS,
McArdle CS</span><br />
<span class="medgenPMjournal">Nutrition</span>
2000 Jun;16(6):425-8.
doi: 10.1016/s0899-9007(00)00270-7.
<span class="bold">PMID: </span><a href="/pubmed/10869897" target="_blank">10869897</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(decreased%20circulating%20iron%20concentration)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">See all (3)</a></div></div>
</div>
<div class="display-none help-popup" id="guidelinesHelpPM">These guidelines are articles in PubMed that match specific search criteria developed by MedGen to capture the most relevant practice guidelines. This list may not be comprehensive and may include broader topics as well. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div><div class="display-none help-popup" id="guidelinesHelpCurated">These guidelines are manually curated by the MedGen team
to supplement articles available in PubMed. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div>
<div class="portlet mgSection" id="ID_103">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_clinical_studies">Recent clinical studies</h1><a sid="103" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln"><h3 class="subhead">Etiology</h3>
<div class="nl"><a target="_blank" href="/pubmed/38711412">Determination of the levels and possible associations of alpha2-macroglobulin with autoantibodies in the serum of patients with various forms of autoimmune thyroiditis.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Rahimova RR,
Efendiyev AM,
Shahverdiyeva IJ,
Dashdamirova GS,
Kerimova IA</span><br />
<span class="medgenPMjournal">Biomed Khim</span>
2024 Apr;70(2):125-129.
doi: 10.18097/PBMC20247002125.
<span class="bold">PMID: </span><a href="/pubmed/38711412" target="_blank">38711412</a></div>
<div class="nl"><a target="_blank" href="/pubmed/37164495">Umbilical cord pH, blood gases, and lactate at birth: normal values, interpretation, and clinical utility.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Olofsson P</span><br />
<span class="medgenPMjournal">Am J Obstet Gynecol</span>
2023 May;228(5S):S1222-S1240.
Epub 2023 Mar 19
doi: 10.1016/j.ajog.2022.07.001.
<span class="bold">PMID: </span><a href="/pubmed/37164495" target="_blank">37164495</a></div>
<div class="nl"><a target="_blank" href="/pubmed/32044999">Dapagliflozin Suppresses Hepcidin And Increases Erythropoiesis.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Ghanim H,
Abuaysheh S,
Hejna J,
Green K,
Batra M,
Makdissi A,
Chaudhuri A,
Dandona P</span><br />
<span class="medgenPMjournal">J Clin Endocrinol Metab</span>
2020 Apr 1;105(4)
doi: 10.1210/clinem/dgaa057.
<span class="bold">PMID: </span><a href="/pubmed/32044999" target="_blank">32044999</a></div>
<div class="nl"><a target="_blank" href="/pubmed/31668584">Modifiable pathways for colorectal cancer: a mendelian randomisation analysis.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Cornish AJ,
Law PJ,
Timofeeva M,
Palin K,
Farrington SM,
Palles C,
Jenkins MA,
Casey G,
Brenner H,
Chang-Claude J,
Hoffmeister M,
Kirac I,
Maughan T,
Brezina S,
Gsur A,
Cheadle JP,
Aaltonen LA,
Tomlinson I,
Dunlop MG,
Houlston RS</span><br />
<span class="medgenPMjournal">Lancet Gastroenterol Hepatol</span>
2020 Jan;5(1):55-62.
Epub 2019 Oct 24
doi: 10.1016/S2468-1253(19)30294-8.
<span class="bold">PMID: </span><a href="/pubmed/31668584" target="_blank">31668584</a><a href="/pmc/articles/PMC7026696" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/27941640">Fibroblast Growth Factor-23-A Potential Uremic Toxin.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Kuczera P,
Adamczak M,
Wiecek A</span><br />
<span class="medgenPMjournal">Toxins (Basel)</span>
2016 Dec 8;8(12)
doi: 10.3390/toxins8120369.
<span class="bold">PMID: </span><a href="/pubmed/27941640" target="_blank">27941640</a><a href="/pmc/articles/PMC5198563" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Decreased%20circulating%20iron%20concentration%22%20AND%20Etiology%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (76)</a></div><h3 class="subhead">Diagnosis</h3>
<div class="nl"><a target="_blank" href="/pubmed/37391133">Decreased levels of perfluoroalkyl substances in patients receiving hemodialysis treatment.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Huang JK,
Chuang YS,
Wu PH,
Tai CJ,
Lin JR,
Kuo MC,
Chiu YW,
Hsu PC,
Wu MT,
Salihovic S,
Lin YT</span><br />
<span class="medgenPMjournal">Sci Total Environ</span>
2023 Oct 20;896:165184.
Epub 2023 Jun 28
doi: 10.1016/j.scitotenv.2023.165184.
<span class="bold">PMID: </span><a href="/pubmed/37391133" target="_blank">37391133</a></div>
<div class="nl"><a target="_blank" href="/pubmed/37164495">Umbilical cord pH, blood gases, and lactate at birth: normal values, interpretation, and clinical utility.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Olofsson P</span><br />
<span class="medgenPMjournal">Am J Obstet Gynecol</span>
2023 May;228(5S):S1222-S1240.
Epub 2023 Mar 19
doi: 10.1016/j.ajog.2022.07.001.
<span class="bold">PMID: </span><a href="/pubmed/37164495" target="_blank">37164495</a></div>
<div class="nl"><a target="_blank" href="/pubmed/36335431">Pitfalls in the interpretation of blood tests used to assess and monitor micronutrient nutrition status.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Berger MM,
Talwar D,
Shenkin A</span><br />
<span class="medgenPMjournal">Nutr Clin Pract</span>
2023 Feb;38(1):56-69.
Epub 2022 Nov 5
doi: 10.1002/ncp.10924.
<span class="bold">PMID: </span><a href="/pubmed/36335431" target="_blank">36335431</a></div>
<div class="nl"><a target="_blank" href="/pubmed/33040077">Morbidly obese subjects show increased serum sulfide in proportion to fat mass.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Comas F,
Latorre J,
Ortega F,
Arnoriaga Rodríguez M,
Lluch A,
Sabater M,
Rius F,
Ribas X,
Costas M,
Ricart W,
Lecube A,
Fernández-Real JM,
Moreno-Navarrete JM</span><br />
<span class="medgenPMjournal">Int J Obes (Lond)</span>
2021 Feb;45(2):415-426.
Epub 2020 Oct 10
doi: 10.1038/s41366-020-00696-z.
<span class="bold">PMID: </span><a href="/pubmed/33040077" target="_blank">33040077</a></div>
<div class="nl"><a target="_blank" href="/pubmed/23555610">Iron and obesity status-associated insulin resistance influence circulating fibroblast-growth factor-23 concentrations.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Fernández-Real JM,
Puig J,
Serrano M,
Sabater M,
Rubió A,
Moreno-Navarrete JM,
Fontan M,
Casamitjana R,
Xifra G,
Ortega FJ,
Salvador J,
Frühbeck G,
Ricart W</span><br />
<span class="medgenPMjournal">PLoS One</span>
2013;8(3):e58961.
Epub 2013 Mar 21
doi: 10.1371/journal.pone.0058961.
<span class="bold">PMID: </span><a href="/pubmed/23555610" target="_blank">23555610</a><a href="/pmc/articles/PMC3605441" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Decreased%20circulating%20iron%20concentration%22%20AND%20Diagnosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (33)</a></div><h3 class="subhead">Therapy</h3>
<div class="nl"><a target="_blank" href="/pubmed/36335431">Pitfalls in the interpretation of blood tests used to assess and monitor micronutrient nutrition status.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Berger MM,
Talwar D,
Shenkin A</span><br />
<span class="medgenPMjournal">Nutr Clin Pract</span>
2023 Feb;38(1):56-69.
Epub 2022 Nov 5
doi: 10.1002/ncp.10924.
<span class="bold">PMID: </span><a href="/pubmed/36335431" target="_blank">36335431</a></div>
<div class="nl"><a target="_blank" href="/pubmed/33918997">Iron Deficiency in Obesity and after Bariatric Surgery.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Bjørklund G,
Peana M,
Pivina L,
Dosa A,
Aaseth J,
Semenova Y,
Chirumbolo S,
Medici S,
Dadar M,
Costea DO</span><br />
<span class="medgenPMjournal">Biomolecules</span>
2021 Apr 21;11(5)
doi: 10.3390/biom11050613.
<span class="bold">PMID: </span><a href="/pubmed/33918997" target="_blank">33918997</a><a href="/pmc/articles/PMC8142987" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/32044999">Dapagliflozin Suppresses Hepcidin And Increases Erythropoiesis.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Ghanim H,
Abuaysheh S,
Hejna J,
Green K,
Batra M,
Makdissi A,
Chaudhuri A,
Dandona P</span><br />
<span class="medgenPMjournal">J Clin Endocrinol Metab</span>
2020 Apr 1;105(4)
doi: 10.1210/clinem/dgaa057.
<span class="bold">PMID: </span><a href="/pubmed/32044999" target="_blank">32044999</a></div>
<div class="nl"><a target="_blank" href="/pubmed/31668584">Modifiable pathways for colorectal cancer: a mendelian randomisation analysis.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Cornish AJ,
Law PJ,
Timofeeva M,
Palin K,
Farrington SM,
Palles C,
Jenkins MA,
Casey G,
Brenner H,
Chang-Claude J,
Hoffmeister M,
Kirac I,
Maughan T,
Brezina S,
Gsur A,
Cheadle JP,
Aaltonen LA,
Tomlinson I,
Dunlop MG,
Houlston RS</span><br />
<span class="medgenPMjournal">Lancet Gastroenterol Hepatol</span>
2020 Jan;5(1):55-62.
Epub 2019 Oct 24
doi: 10.1016/S2468-1253(19)30294-8.
<span class="bold">PMID: </span><a href="/pubmed/31668584" target="_blank">31668584</a><a href="/pmc/articles/PMC7026696" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/23124094">Defected red blood cell membranes and direct correlation with the uraemic milieu: the connection with the decreased red blood cell lifespan observed in haemodialysis patients.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Stamopoulos D,
Grapsa E,
Manios E,
Gogola V,
Bakirtzi N</span><br />
<span class="medgenPMjournal">Nanotechnology</span>
2012 Dec 7;23(48):485101.
Epub 2012 Nov 2
doi: 10.1088/0957-4484/23/48/485101.
<span class="bold">PMID: </span><a href="/pubmed/23124094" target="_blank">23124094</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Decreased%20circulating%20iron%20concentration%22%20AND%20Therapy%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (65)</a></div><h3 class="subhead">Prognosis</h3>
<div class="nl"><a target="_blank" href="/pubmed/34099582">Role of hepcidin in physiology and pathophysiology. Emerging experimental and clinical evidence.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Wojciechowska M,
Wisniewski OW,
Kolodziejski P,
Krauss H</span><br />
<span class="medgenPMjournal">J Physiol Pharmacol</span>
2021 Feb;72(1)
Epub 2021 Jun 3
doi: 10.26402/jpp.2021.1.03.
<span class="bold">PMID: </span><a href="/pubmed/34099582" target="_blank">34099582</a></div>
<div class="nl"><a target="_blank" href="/pubmed/32044999">Dapagliflozin Suppresses Hepcidin And Increases Erythropoiesis.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Ghanim H,
Abuaysheh S,
Hejna J,
Green K,
Batra M,
Makdissi A,
Chaudhuri A,
Dandona P</span><br />
<span class="medgenPMjournal">J Clin Endocrinol Metab</span>
2020 Apr 1;105(4)
doi: 10.1210/clinem/dgaa057.
<span class="bold">PMID: </span><a href="/pubmed/32044999" target="_blank">32044999</a></div>
<div class="nl"><a target="_blank" href="/pubmed/31668584">Modifiable pathways for colorectal cancer: a mendelian randomisation analysis.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Cornish AJ,
Law PJ,
Timofeeva M,
Palin K,
Farrington SM,
Palles C,
Jenkins MA,
Casey G,
Brenner H,
Chang-Claude J,
Hoffmeister M,
Kirac I,
Maughan T,
Brezina S,
Gsur A,
Cheadle JP,
Aaltonen LA,
Tomlinson I,
Dunlop MG,
Houlston RS</span><br />
<span class="medgenPMjournal">Lancet Gastroenterol Hepatol</span>
2020 Jan;5(1):55-62.
Epub 2019 Oct 24
doi: 10.1016/S2468-1253(19)30294-8.
<span class="bold">PMID: </span><a href="/pubmed/31668584" target="_blank">31668584</a><a href="/pmc/articles/PMC7026696" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/30991224">Circulating essential metals and lung cancer: Risk assessment and potential molecular effects.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Bai Y,
Wang G,
Fu W,
Lu Y,
Wei W,
Chen W,
Wu X,
Meng H,
Feng Y,
Liu Y,
Li G,
Wang S,
Wang K,
Dai J,
Li H,
Li M,
Huang J,
Li Y,
Wei S,
Yuan J,
Yao P,
Miao X,
He M,
Zhang X,
Yang H,
Wu T,
Guo H</span><br />
<span class="medgenPMjournal">Environ Int</span>
2019 Jun;127:685-693.
Epub 2019 Apr 13
doi: 10.1016/j.envint.2019.04.021.
<span class="bold">PMID: </span><a href="/pubmed/30991224" target="_blank">30991224</a></div>
<div class="nl"><a target="_blank" href="/pubmed/27941640">Fibroblast Growth Factor-23-A Potential Uremic Toxin.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Kuczera P,
Adamczak M,
Wiecek A</span><br />
<span class="medgenPMjournal">Toxins (Basel)</span>
2016 Dec 8;8(12)
doi: 10.3390/toxins8120369.
<span class="bold">PMID: </span><a href="/pubmed/27941640" target="_blank">27941640</a><a href="/pmc/articles/PMC5198563" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Decreased%20circulating%20iron%20concentration%22%20AND%20Prognosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (35)</a></div><h3 class="subhead">Clinical prediction guides</h3>
<div class="nl"><a target="_blank" href="/pubmed/37164495">Umbilical cord pH, blood gases, and lactate at birth: normal values, interpretation, and clinical utility.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Olofsson P</span><br />
<span class="medgenPMjournal">Am J Obstet Gynecol</span>
2023 May;228(5S):S1222-S1240.
Epub 2023 Mar 19
doi: 10.1016/j.ajog.2022.07.001.
<span class="bold">PMID: </span><a href="/pubmed/37164495" target="_blank">37164495</a></div>
<div class="nl"><a target="_blank" href="/pubmed/34099582">Role of hepcidin in physiology and pathophysiology. Emerging experimental and clinical evidence.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Wojciechowska M,
Wisniewski OW,
Kolodziejski P,
Krauss H</span><br />
<span class="medgenPMjournal">J Physiol Pharmacol</span>
2021 Feb;72(1)
Epub 2021 Jun 3
doi: 10.26402/jpp.2021.1.03.
<span class="bold">PMID: </span><a href="/pubmed/34099582" target="_blank">34099582</a></div>
<div class="nl"><a target="_blank" href="/pubmed/31668584">Modifiable pathways for colorectal cancer: a mendelian randomisation analysis.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Cornish AJ,
Law PJ,
Timofeeva M,
Palin K,
Farrington SM,
Palles C,
Jenkins MA,
Casey G,
Brenner H,
Chang-Claude J,
Hoffmeister M,
Kirac I,
Maughan T,
Brezina S,
Gsur A,
Cheadle JP,
Aaltonen LA,
Tomlinson I,
Dunlop MG,
Houlston RS</span><br />
<span class="medgenPMjournal">Lancet Gastroenterol Hepatol</span>
2020 Jan;5(1):55-62.
Epub 2019 Oct 24
doi: 10.1016/S2468-1253(19)30294-8.
<span class="bold">PMID: </span><a href="/pubmed/31668584" target="_blank">31668584</a><a href="/pmc/articles/PMC7026696" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/23124094">Defected red blood cell membranes and direct correlation with the uraemic milieu: the connection with the decreased red blood cell lifespan observed in haemodialysis patients.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Stamopoulos D,
Grapsa E,
Manios E,
Gogola V,
Bakirtzi N</span><br />
<span class="medgenPMjournal">Nanotechnology</span>
2012 Dec 7;23(48):485101.
Epub 2012 Nov 2
doi: 10.1088/0957-4484/23/48/485101.
<span class="bold">PMID: </span><a href="/pubmed/23124094" target="_blank">23124094</a></div>
<div class="nl"><a target="_blank" href="/pubmed/12553165">Brain iron homeostasis.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Moos T</span><br />
<span class="medgenPMjournal">Dan Med Bull</span>
2002 Nov;49(4):279-301.
<span class="bold">PMID: </span><a href="/pubmed/12553165" target="_blank">12553165</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Decreased%20circulating%20iron%20concentration%22%20AND%20Clinical%20prediction%20guides%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (53)</a></div></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Adani G,
Filippini T,
Michalke B,
Vinceti M</span><br />
<span class="medgenPMjournal">Neuroepidemiology</span>
2020;54(1):1-23.
Epub 2019 Aug 27
doi: 10.1159/000502357.
<span class="bold">PMID: </span><a href="/pubmed/31454800" target="_blank">31454800</a></div>
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