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<meta name="keywords" content="C1829460, finding, tongue thrust, tongue thrusting, tt - tongue thrust, autosomal dominant, autosomal recessive, birth defects, chromosomal disease, chromosome, clinical features, clinical findings, clinical genetics, clinical recommendations, clinvar, congenital chromosomal disease, consumer genetic resources, cytogenetic location, disease characteristics, disease definitions, disease descriptions, disease ontology, disease synonyms, disease vocabulary, dysmorphology, entrez, familial disease, gene, gene-disease relationship, genereviews, genetic disease, genetic disorder, genetic terminology, genetic testing registry, genetics home reference, genomic disease, gtr, hereditary disease, heritable disease, hpo, human phenotype ontology, inherited disease, management guidelines, maternal inheritance, medgen, medical genetics, medical subject headings, mesh, mitochondrial inheritance, mode of inheritance, national center for biotechnology information, national institutes of health, national library of medicine, ncbi, nih, nlm, omim, ordo, orphanet, paternal inheritance, phenome, position statements, professional practice guidelines, rare disease, reference sequence, refseq, snomed ct, syndrome, undiagnosed diseases, x-linked recessive" /><meta name="description" content="Pressing forward of the tongue in the mouth, a retained motoric habit from infantile swallowing patterns" /><meta name="robots" content="index,nofollow,noarchive" />
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<!--
UID=473491
ConceptID=C1829460
-->
<!--imgCountBooks = 0--><h1 class="medgenTitle"><div class="MedGenTitleText">Tongue thrusting</div></h1><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>473491</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C1829460</a></dd><dt><span class="dotprefix"></span></dt><dd>Finding</dd></dl></div></div><table class="medgenTable"><tbody><tr><td>Synonyms:</td>
<td>Tongue thrust; TT - Tongue thrust</td></tr>
<tr><td><span class="bold">SNOMED CT: </span></td>
<td>TT - Tongue thrust (110343009); Tongue thrust (110343009); Tongue thrusting (424583005)</td></tr>
<tr><td colspan="2" class="small"> </td></tr><tr><td>HPO:</td>
<td><a target="_blank" title="Human Phenotype Ontology" href="https://hpo.jax.org/app/browse/term/HP:0100703">HP:0100703</a></td></tr>
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<div class="portlet mgSection" id="ID_100">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Definition">Definition</h1><a sid="100" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln">Pressing forward of the tongue in the mouth, a retained motoric habit from infantile swallowing patterns [from <a title="Human Phenotype Ontology" href="http://www.human-phenotype-ontology.org" class="defSource" target="_blank">HPO</a>]</div>
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<div class="portlet mgSection" id="ID_118">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Term_Hierarchy">Term Hierarchy</h1><a sid="118" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln HierarchyGTR"><div class="jig-ncbitabs"><ul><li><a href="#tabGTR">GTR</a></li><li><a href="#tabMGEN">MeSH</a></li></ul><div id="tabGTR"><div class="search_result"><div class="rprts"><div class="chiclet_legend"><span class="chiclet_list" style="position:static;"><span title="Clinical test" class="chiclet Ccolor round">C</span><span>Clinical test,  </span><span title="Research test" class="chiclet Rcolor round">R</span><span>Research test,  </span><span title="OMIM" class="chiclet Ocolor ">O</span><span>OMIM,  </span><span title="GeneReview" class="chiclet Gcolor">G</span><span><em>GeneReviews</em>,  </span><span title="ClinVar" class="chiclet Vcolor">V</span><span>ClinVar  </span></span></div><div id="hierarchy" class="margin_t1"><div class="ds_tree"><ul><li class="matched_ds"><span class="chiclet_list"><span class="chiclet unavailable round" title="Clinical test">C</span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet unavailable" title="OMIM">O</span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet unavailable" title="ClinVar">V</span></span><span class="TLline">Tongue thrusting</span></li></ul></div></div></div></div></div><div id="tabMGEN"><div class="ds_tree"><ul><li><span class="TLline"><a href="/medgen/21047" ref="tree=MeSH" title="MedGen record for Pathological Conditions, Signs and Symptoms">Pathological Conditions, Signs and Symptoms</a></span><ul><li><span class="TLline"><a href="/medgen/19974" ref="tree=MeSH" title="MedGen record for Clinical finding">Clinical finding</a></span><ul><li><span class="TLline"><a href="/medgen/272632" ref="tree=MeSH" title="MedGen record for Finding by Site or System">Finding by Site or System</a></span><ul><li><span class="TLline"><a href="/medgen/98386" ref="tree=MeSH" title="MedGen record for Neurological finding">Neurological finding</a></span><ul><li><span class="TLline"><a href="/medgen/21318" ref="tree=MeSH" title="MedGen record for Motor stereotypies">Motor stereotypies</a></span><ul><li><span class="TLline"><a href="/medgen/1841974" ref="tree=MeSH" title="MedGen record for Stereotypic movements of face and head">Stereotypic movements of face and head</a></span><ul><li><span class="matched_ds">Tongue thrusting</span></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></div></div></div></div>
</div>
<div class="portlet mgSection" id="ID_112">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Conditions_with_this_feature">Conditions with this feature</h1><a sid="112" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln clinfeat">
<div class="divPopper rprt" id="rdis_452447"><div><strong>D-Glyceric aciduria</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>452447</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C0342765</a></dd><dt><span class="dotprefix"></span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
<div class="spaceAbove">D-glyceric aciduria is a rare autosomal recessive metabolic disorder with a highly variable phenotype. Some patients have an encephalopathic presentation, with severely impaired intellectual development, seizures, microcephaly, and sometimes early death, whereas others have a mild phenotype with only mild speech delay or even normal development (summary by Sass et al., 2010).</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/452447">Condition Record</a></div></div>
<div class="divPopper rprt" id="rdis_266149"><div><strong>Cardio-facio-cutaneous syndrome</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>266149</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C1275081</a></dd><dt><span class="dotprefix"></span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
<div class="spaceAbove">Cardiofaciocutaneous (CFC) syndrome is characterized by cardiac abnormalities (pulmonic stenosis and other valve dysplasias, septal defects, hypertrophic cardiomyopathy, rhythm disturbances), distinctive craniofacial appearance, and cutaneous abnormalities (including xerosis, hyperkeratosis, ichthyosis, keratosis pilaris, ulerythema ophryogenes, eczema, pigmented moles, hemangiomas, and palmoplantar hyperkeratosis). The hair is typically sparse, curly, fine or thick, and woolly or brittle; eyelashes and eyebrows may be absent or sparse. Nails may be dystrophic or fast growing. Affected individuals typically have some form of neurologic and/or cognitive delay (ranging from mild to severe). Most individuals have severe feeding issues, which can contribute to poor growth, and many require nasogastric or gastrostomy tube feeding. Many affected individuals have eye findings, including strabismus, nystagmus, refractive errors, and optic nerve hypoplasia. Seizures may be present and can be refractory to therapy.</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/266149">Condition Record</a></div></div>
<div class="divPopper rprt" id="rdis_220945"><div><strong>Deficiency of aromatic-L-amino-acid decarboxylase</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>220945</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C1291564</a></dd><dt><span class="dotprefix"></span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
<div class="spaceAbove">Individuals with aromatic L-amino acid decarboxylase (AADC) deficiency typically have complex symptoms, including motor, behavioral, cognitive, and autonomic findings. Symptom onset is in early infancy, typically within the first six months of life. The most common initial symptoms are often nonspecific, and include feeding difficulties, hypotonia, and developmental delay. More specific symptoms include oculogyric crises (which occur in the vast majority of affected individuals, typically starting in infancy), movement disorders (especially dystonia), and autonomic dysfunction (excessive sweating, temperature instability, ptosis, nasal congestion, hypoglycemic episodes). Sleep disturbance is present in a majority of affected individuals and can include insomnia, hypersomnia, or both. Mood disturbance, including irritability and anxiety, are also common. Brain MRI is typically either normal or may demonstrate nonspecific abnormalities, such as mild diffuse cerebral atrophy or delayed myelination. Seizures are an uncommon finding, occurring in fewer than 5% of affected individuals.</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/220945">Condition Record</a></div></div>
<div class="divPopper rprt" id="rdis_339994"><div><strong>Phelan-McDermid syndrome</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>339994</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C1853490</a></dd><dt><span class="dotprefix"></span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
<div class="spaceAbove">Phelan-McDermid syndrome-SHANK3 related (PMS-SHANK3 related) is characterized by neonatal hypotonia, absent to severely delayed speech, developmental delay, and minor dysmorphic facial features. Most affected individuals have moderate-to-profound intellectual disability. Other features include relatively large fleshy hands, dysplastic toenails, and decreased perspiration that results in a tendency to overheat. Normal stature and normal head size distinguish PMS-SHANK3 related from other autosomal chromosome disorders. Neurobehavioral characteristics include mouthing or chewing non-food items, decreased perception of pain, and autism spectrum disorder or autistic-like affect and behavior. Some individuals experience regression / loss of skills, epilepsy, ataxic/abnormal gait, and sleep disturbance (difficulty falling asleep and staying asleep, hypersomnia, and parasomnias). Less commonly, affected individuals may have strabismus, vision problems (hyperopia or myopia), cardiac anomalies, renal anomalies, and lymphedema. Those who have PMS-SHANK3 related due to a ring chromosome 22 also have a high risk of developing features of NF2-related schwannomatosis (NF2).</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/339994">Condition Record</a></div></div>
<div class="divPopper rprt" id="rdis_462055"><div><strong>Rett syndrome, congenital variant</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>462055</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C3150705</a></dd><dt><span class="dotprefix"></span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
<div class="spaceAbove">FOXG1 syndrome is characterized by moderate-to-profound developmental delay and intellectual disability, postnatal growth deficiency, congenital or postnatal microcephaly, hyperkinetic/dyskinetic movement disorder, hypotonia, neurobehavioral/psychiatric manifestations (motor stereotypies, impairment of social interaction, abnormal sleep patterns, unexplained episodes of crying, restlessness, and bruxism), feeding difficulties with poor weight gain, strabismus, seizures, spasticity, gastroesophageal reflux, and aspiration. Some individuals have cortical visual impairment, kyphosis, scoliosis, and/or abnormal breathing. Characteristic neuroimaging findings include corpus callosum anomalies (especially a marked, filiform thinning of the rostrum of the corpus callosum), a simplified gyral pattern, and hyperplasia of the fornices.</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/462055">Condition Record</a></div></div>
<div class="divPopper rprt" id="rdis_1647077"><div><strong>Neurodevelopmental disorder with movement abnormalities, abnormal gait, and autistic features</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1647077</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C4693405</a></dd><dt><span class="dotprefix"></span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
<div class="spaceAbove">Neurodevelopmental disorder with movement abnormalities, abnormal gait, and autistic features (NEDMAGA) is characterized by infantile-onset global developmental delay with severe to profound intellectual disability, mildly delayed walking with broad-based and unsteady gait, and absence of meaningful language. Patients have features of autism, with repetitive behaviors and poor communication, but usually are socially reactive and have a happy demeanor. More variable neurologic features include mild seizures, spasticity, and peripheral neuropathy (summary by Palmer et al., 2017).</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/1647077">Condition Record</a></div></div>
<div class="divPopper rprt" id="rdis_1794216"><div><strong>Neurodevelopmental disorder with impaired language and ataxia and with or without seizures</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1794216</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C5562006</a></dd><dt><span class="dotprefix"></span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
<div class="spaceAbove">Neurodevelopmental disorder with impaired language and ataxia and with or without seizures (NEDLAS) is characterized by axial hypotonia and global developmental delay apparent in early infancy. Affected individuals have delayed walking with gait ataxia and poor language development. Behavioral abnormalities also commonly occur. The severity is highly variable: a subset of patients have a more severe phenotype with early-onset seizures resembling epileptic encephalopathy, inability to walk or speak, and hypomyelination on brain imaging (summary by Stolz et al., 2021).</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/1794216">Condition Record</a></div></div>
<div class="divPopper rprt" id="rdis_1799566"><div><strong>DYRK1A-related intellectual disability syndrome</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1799566</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C5568143</a></dd><dt><span class="dotprefix"></span></dt><dd>Mental or Behavioral Dysfunction</dd></dl></div></div></div>
<div class="spaceAbove">DYRK1A syndrome is characterized by intellectual disability including impaired speech development, autism spectrum disorder including anxious and/or stereotypic behavior problems, and microcephaly. Affected individuals often have a clinically recognizable phenotype including a typical facial gestalt, feeding problems, seizures, hypertonia, gait disturbances, and foot anomalies. The majority of affected individuals function in the moderate-to-severe range of intellectual disability; however, individuals with mild intellectual disability have also been reported. Other medical concerns relate to febrile seizures in infancy; the development of epilepsy with seizures of the atonic, absence, and generalized myoclonic types; short stature; and gastrointestinal problems. Ophthalmologic, urogenital, cardiac, and/or dental anomalies have been reported.</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/1799566">Condition Record</a></div></div>
<div class="divPopper rprt" id="rdis_1841189"><div><strong>Intellectual developmental disorder, autosomal recessive 79</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1841189</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C5830553</a></dd><dt><span class="dotprefix"></span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
<div class="spaceAbove">Autosomal recessive intellectual developmental disorder-79 (MRT79) is characterized by global developmental delay apparent from infancy. Affected individuals have mildly delayed walking with an ataxic gait and severely impaired intellectual development with poor or absent speech. Additional features may include postnatal microcephaly and dysmorphic features (Van Bergen et al., 2022).</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/1841189">Condition Record</a></div></div>
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_266149" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Cardio-facio-cutaneous syndrome</a></div>
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_452447" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">D-Glyceric aciduria</a></div>
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_220945" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Deficiency of aromatic-L-amino-acid decarboxylase</a></div>
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1799566" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">DYRK1A-related intellectual disability syndrome</a></div>
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1841189" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Intellectual developmental disorder, autosomal recessive 79</a></div><div class="jig-moreless" data-jigconfig="class: 'moveDown', moreText: 'See full list (9)', lessText: 'Show less', nodeBefore: 0"><span id="clinMore">
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1794216" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Neurodevelopmental disorder with impaired language and ataxia and with or without seizures</a></div>
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1647077" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Neurodevelopmental disorder with movement abnormalities, abnormal gait, and autistic features</a></div>
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_339994" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Phelan-McDermid syndrome</a></div>
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_462055" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Rett syndrome, congenital variant</a></div></span></div></div>
</div>
<div class="portlet mgSection" id="ID_105">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Professional_guidelines">Professional guidelines</h1><a sid="105" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln"><h3 class="subhead">PubMed<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpPM"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3>
<div class="nl"><a target="_blank" href="/pubmed/27295847">THE ESSENTIAL ROLE OF THE COM IN THE MANAGEMENT OF SLEEP-DISORDERED BREATHING: A LITERATURE REVIEW AND DISCUSSION.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Frey L,
Green S,
Fabbie P,
Hockenbury D,
Foran M,
Elder K</span><br />
<span class="medgenPMjournal">Int J Orofacial Myology</span>
2014 Nov;40:42-55.
<span class="bold">PMID: </span><a href="/pubmed/27295847" target="_blank">27295847</a></div>
<div class="nl"><a target="_blank" href="/pubmed/7923510">Changes in oral functions and muscular behavior due to surgical orthodontic treatment.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Yamaguchi H,
Tanaka Y,
Sueishi K,
Sebata M,
Uchiyama T,
Saito C,
Sigematsu T</span><br />
<span class="medgenPMjournal">Bull Tokyo Dent Coll</span>
1994 Feb;35(1):41-9.
<span class="bold">PMID: </span><a href="/pubmed/7923510" target="_blank">7923510</a></div>
<div class="nl"><a target="_blank" href="/pubmed/5240768">Management of digital sucking and tongue thrusting in children.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Norton LA,
Gellin ME</span><br />
<span class="medgenPMjournal">Dent Clin North Am</span>
1968 Jul:363-82.
<span class="bold">PMID: </span><a href="/pubmed/5240768" target="_blank">5240768</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(%22tongue%20thrusting%22%5Btiab%3A~0%5D)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">See all (4)</a></div></div>
</div>
<div class="display-none help-popup" id="guidelinesHelpPM">These guidelines are articles in PubMed that match specific search criteria developed by MedGen to capture the most relevant practice guidelines. This list may not be comprehensive and may include broader topics as well. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div><div class="display-none help-popup" id="guidelinesHelpCurated">These guidelines are manually curated by the MedGen team
to supplement articles available in PubMed. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div>
<div class="portlet mgSection" id="ID_103">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_clinical_studies">Recent clinical studies</h1><a sid="103" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln"><h3 class="subhead">Etiology</h3>
<div class="nl"><a target="_blank" href="/pubmed/30889292">Voice and swallowing dysfunction in X-linked dystonia parkinsonism.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Song PC,
Le H,
Acuna P,
De Guzman JKP,
Sharma N,
Francouer TN,
Dy ME,
Go CL</span><br />
<span class="medgenPMjournal">Laryngoscope</span>
2020 Jan;130(1):171-177.
Epub 2019 Mar 19
doi: 10.1002/lary.27897.
<span class="bold">PMID: </span><a href="/pubmed/30889292" target="_blank">30889292</a></div>
<div class="nl"><a target="_blank" href="/pubmed/31081951">The effect of tongue thrusting on tongue pressure production during swallowing in adult anterior open bite cases.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Kurihara K,
Fukui T,
Sakaue K,
Hori K,
Ono T,
Saito I</span><br />
<span class="medgenPMjournal">J Oral Rehabil</span>
2019 Oct;46(10):895-902.
Epub 2019 May 25
doi: 10.1111/joor.12820.
<span class="bold">PMID: </span><a href="/pubmed/31081951" target="_blank">31081951</a></div>
<div class="nl"><a target="_blank" href="/pubmed/25514258">Oral habits--part 2: beyond nutritive and non-nutritive sucking.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Silva M,
Manton D</span><br />
<span class="medgenPMjournal">J Dent Child (Chic)</span>
2014 Sep-Dec;81(3):140-6.
<span class="bold">PMID: </span><a href="/pubmed/25514258" target="_blank">25514258</a></div>
<div class="nl"><a target="_blank" href="/pubmed/24812738">NTRDC retainer: a novel approach for both retention and habit control--a follow up of 2 years.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Mathur A,
Thakur A,
Toshniwal NG,
Misal A,
Kharbanda OP</span><br />
<span class="medgenPMjournal">Int J Orthod Milwaukee</span>
2014 Spring;25(1):27-9.
<span class="bold">PMID: </span><a href="/pubmed/24812738" target="_blank">24812738</a></div>
<div class="nl"><a target="_blank" href="/pubmed/18271768">Dental treatment of children with Angelman syndrome: a case report.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Murakami C,
Nahás Pires Corrêa MS,
Nahás Pires Corrêa F,
Nahás Pires Corrêa JP</span><br />
<span class="medgenPMjournal">Spec Care Dentist</span>
2008 Jan-Feb;28(1):8-11.
doi: 10.1111/j.1754-4505.2008.00003.x.
<span class="bold">PMID: </span><a href="/pubmed/18271768" target="_blank">18271768</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Tongue%20thrusting%22%20AND%20Etiology%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (33)</a></div><h3 class="subhead">Diagnosis</h3>
<div class="nl"><a target="_blank" href="/pubmed/29040795">Case Presentation of Anti-NMDA Receptor Encephalitis in a 4-Year-Old Boy.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Gbadero DA,
Adegbite EO,
LePichon JB,
Slusher TM</span><br />
<span class="medgenPMjournal">J Trop Pediatr</span>
2018 Aug 1;64(4):352-354.
doi: 10.1093/tropej/fmx070.
<span class="bold">PMID: </span><a href="/pubmed/29040795" target="_blank">29040795</a></div>
<div class="nl"><a target="_blank" href="/pubmed/25514258">Oral habits--part 2: beyond nutritive and non-nutritive sucking.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Silva M,
Manton D</span><br />
<span class="medgenPMjournal">J Dent Child (Chic)</span>
2014 Sep-Dec;81(3):140-6.
<span class="bold">PMID: </span><a href="/pubmed/25514258" target="_blank">25514258</a></div>
<div class="nl"><a target="_blank" href="/pubmed/15055637">Burning mouth syndrome: a guide for the general practitioner.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Pinto A,
Stoopler ET,
DeRossi SS,
Sollecito TP,
Popovic R</span><br />
<span class="medgenPMjournal">Gen Dent</span>
2003 Sep-Oct;51(5):458-61; quiz 462.
<span class="bold">PMID: </span><a href="/pubmed/15055637" target="_blank">15055637</a></div>
<div class="nl"><a target="_blank" href="/pubmed/9260231">Oral manifestations in Rett syndrome: a study of 17 cases.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Ribeiro RA,
Romano AR,
Birman EG,
Mayer MP</span><br />
<span class="medgenPMjournal">Pediatr Dent</span>
1997 Jul-Aug;19(5):349-52.
<span class="bold">PMID: </span><a href="/pubmed/9260231" target="_blank">9260231</a></div>
<div class="nl"><a target="_blank" href="/pubmed/4528829">Tongue-thrusting patterns and the lower incisors.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Massengill R Jr,
Quinn G,
Hall AS,
Boyd D</span><br />
<span class="medgenPMjournal">Am J Orthod</span>
1974 Sep;66(3):287-93.
doi: 10.1016/0002-9416(74)90293-0.
<span class="bold">PMID: </span><a href="/pubmed/4528829" target="_blank">4528829</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Tongue%20thrusting%22%20AND%20Diagnosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (25)</a></div><h3 class="subhead">Therapy</h3>
<div class="nl"><a target="_blank" href="/pubmed/29040795">Case Presentation of Anti-NMDA Receptor Encephalitis in a 4-Year-Old Boy.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Gbadero DA,
Adegbite EO,
LePichon JB,
Slusher TM</span><br />
<span class="medgenPMjournal">J Trop Pediatr</span>
2018 Aug 1;64(4):352-354.
doi: 10.1093/tropej/fmx070.
<span class="bold">PMID: </span><a href="/pubmed/29040795" target="_blank">29040795</a></div>
<div class="nl"><a target="_blank" href="/pubmed/28057843">Diphenhydramine for Acute Extrapyramidal Symptoms After Propofol Administration.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Sherer J,
Salazar T,
Schesing KB,
McPartland S,
Kornitzer J</span><br />
<span class="medgenPMjournal">Pediatrics</span>
2017 Feb;139(2)
Epub 2017 Jan 5
doi: 10.1542/peds.2016-1135.
<span class="bold">PMID: </span><a href="/pubmed/28057843" target="_blank">28057843</a></div>
<div class="nl"><a target="_blank" href="/pubmed/25514258">Oral habits--part 2: beyond nutritive and non-nutritive sucking.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Silva M,
Manton D</span><br />
<span class="medgenPMjournal">J Dent Child (Chic)</span>
2014 Sep-Dec;81(3):140-6.
<span class="bold">PMID: </span><a href="/pubmed/25514258" target="_blank">25514258</a></div>
<div class="nl"><a target="_blank" href="/pubmed/24851391">Rigo-Fede disease: case report.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Lee J,
Mandel L</span><br />
<span class="medgenPMjournal">N Y State Dent J</span>
2014 Mar;80(2):36-7.
<span class="bold">PMID: </span><a href="/pubmed/24851391" target="_blank">24851391</a></div>
<div class="nl"><a target="_blank" href="/pubmed/18797376">An infant with obtundation and tongue thrusting. Phencyclidine poisoning.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Seiden JA,
Mittal MK</span><br />
<span class="medgenPMjournal">Pediatr Emerg Care</span>
2008 Sep;24(9):629-31.
doi: 10.1097/PEC.0b013e3181852248.
<span class="bold">PMID: </span><a href="/pubmed/18797376" target="_blank">18797376</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Tongue%20thrusting%22%20AND%20Therapy%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (29)</a></div><h3 class="subhead">Prognosis</h3>
<div class="nl"><a target="_blank" href="/pubmed/30777516">Association between buccal mucosa ridging and oral feature/symptom and its effects on occlusal function among dentate young adults in a cross-sectional study of Japan.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Morita K,
Tsuka H,
Kuremoto KI,
Kimura H,
Kawano H,
Yokoi M,
Yasuda K,
Yoshida M,
Tsuga K</span><br />
<span class="medgenPMjournal">Cranio</span>
2021 Jan;39(1):24-28.
Epub 2019 Feb 19
doi: 10.1080/08869634.2019.1581471.
<span class="bold">PMID: </span><a href="/pubmed/30777516" target="_blank">30777516</a></div>
<div class="nl"><a target="_blank" href="/pubmed/27310290">Clinical variability of neuroacanthocytosis syndromes-a series of six patients with long follow-up.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Dulski J,
Sołtan W,
Schinwelski M,
Rudzińska M,
Wójcik-Pędziwiatr M,
Wictor L,
Schön F,
Puschmann A,
Klempíř J,
Tilley L,
Roth J,
Tacik P,
Fujioka S,
Drozdowski W,
Sitek EJ,
Wszolek Z,
Sławek J</span><br />
<span class="medgenPMjournal">Clin Neurol Neurosurg</span>
2016 Aug;147:78-83.
Epub 2016 Jun 1
doi: 10.1016/j.clineuro.2016.05.028.
<span class="bold">PMID: </span><a href="/pubmed/27310290" target="_blank">27310290</a></div>
<div class="nl"><a target="_blank" href="/pubmed/26126836">Narcolepsy in a three-year-old girl: A case report.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Park EG,
Lee J,
Joo EY,
Lee M,
Lee J</span><br />
<span class="medgenPMjournal">Brain Dev</span>
2016 Jan;38(1):139-41.
Epub 2015 Jun 28
doi: 10.1016/j.braindev.2015.06.003.
<span class="bold">PMID: </span><a href="/pubmed/26126836" target="_blank">26126836</a></div>
<div class="nl"><a target="_blank" href="/pubmed/24812738">NTRDC retainer: a novel approach for both retention and habit control--a follow up of 2 years.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Mathur A,
Thakur A,
Toshniwal NG,
Misal A,
Kharbanda OP</span><br />
<span class="medgenPMjournal">Int J Orthod Milwaukee</span>
2014 Spring;25(1):27-9.
<span class="bold">PMID: </span><a href="/pubmed/24812738" target="_blank">24812738</a></div>
<div class="nl"><a target="_blank" href="/pubmed/18271768">Dental treatment of children with Angelman syndrome: a case report.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Murakami C,
Nahás Pires Corrêa MS,
Nahás Pires Corrêa F,
Nahás Pires Corrêa JP</span><br />
<span class="medgenPMjournal">Spec Care Dentist</span>
2008 Jan-Feb;28(1):8-11.
doi: 10.1111/j.1754-4505.2008.00003.x.
<span class="bold">PMID: </span><a href="/pubmed/18271768" target="_blank">18271768</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Tongue%20thrusting%22%20AND%20Prognosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (10)</a></div><h3 class="subhead">Clinical prediction guides</h3>
<div class="nl"><a target="_blank" href="/pubmed/33525609">Oral Manifestations of Rett Syndrome-A Systematic Review.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Mahdi SS,
Jafri HA,
Allana R,
Amenta F,
Khawaja M,
Qasim SSB</span><br />
<span class="medgenPMjournal">Int J Environ Res Public Health</span>
2021 Jan 28;18(3)
doi: 10.3390/ijerph18031162.
<span class="bold">PMID: </span><a href="/pubmed/33525609" target="_blank">33525609</a><a href="/pmc/articles/PMC7908587" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/30889292">Voice and swallowing dysfunction in X-linked dystonia parkinsonism.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Song PC,
Le H,
Acuna P,
De Guzman JKP,
Sharma N,
Francouer TN,
Dy ME,
Go CL</span><br />
<span class="medgenPMjournal">Laryngoscope</span>
2020 Jan;130(1):171-177.
Epub 2019 Mar 19
doi: 10.1002/lary.27897.
<span class="bold">PMID: </span><a href="/pubmed/30889292" target="_blank">30889292</a></div>
<div class="nl"><a target="_blank" href="/pubmed/27475682">Impact of rare diseases in oral health.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Molina-García A,
Castellanos-Cosano L,
Machuca-Portillo G,
Posada-de la Paz M</span><br />
<span class="medgenPMjournal">Med Oral Patol Oral Cir Bucal</span>
2016 Sep 1;21(5):e587-94.
doi: 10.4317/medoral.20972.
<span class="bold">PMID: </span><a href="/pubmed/27475682" target="_blank">27475682</a><a href="/pmc/articles/PMC5005096" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/9260231">Oral manifestations in Rett syndrome: a study of 17 cases.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Ribeiro RA,
Romano AR,
Birman EG,
Mayer MP</span><br />
<span class="medgenPMjournal">Pediatr Dent</span>
1997 Jul-Aug;19(5):349-52.
<span class="bold">PMID: </span><a href="/pubmed/9260231" target="_blank">9260231</a></div>
<div class="nl"><a target="_blank" href="/pubmed/5573267">Tongue thrusting: some clinical observations.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Wood JM</span><br />
<span class="medgenPMjournal">J Speech Hear Disord</span>
1971 Feb;36(1):82-9.
doi: 10.1044/jshd.3601.82.
<span class="bold">PMID: </span><a href="/pubmed/5573267" target="_blank">5573267</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Tongue%20thrusting%22%20AND%20Clinical%20prediction%20guides%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (29)</a></div></div>
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Jafri HA,
Allana R,
Amenta F,
Khawaja M,
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<span class="medgenPMjournal">Int J Environ Res Public Health</span>
2021 Jan 28;18(3)
doi: 10.3390/ijerph18031162.
<span class="bold">PMID: </span><a href="/pubmed/33525609" target="_blank">33525609</a><a href="/pmc/articles/PMC7908587" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/27475682">Impact of rare diseases in oral health.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Molina-García A,
Castellanos-Cosano L,
Machuca-Portillo G,
Posada-de la Paz M</span><br />
<span class="medgenPMjournal">Med Oral Patol Oral Cir Bucal</span>
2016 Sep 1;21(5):e587-94.
doi: 10.4317/medoral.20972.
<span class="bold">PMID: </span><a href="/pubmed/27475682" target="_blank">27475682</a><a href="/pmc/articles/PMC5005096" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Tongue%20thrusting%22%20AND%20systematic%5Bsb%5D%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (2)</a></div></div>
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