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<!--
|
||
UID=451035
|
||
ConceptID=C0332573
|
||
-->
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||
<!--imgCountBooks = 0--><h1 class="medgenTitle"><div class="MedGenTitleText">Macule</div></h1><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>451035</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0332573</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Finding; Sign or Symptom</dd></dl></div></div><table class="medgenTable"><tbody><tr><td>Synonyms:</td>
|
||
<td>Flat, discolored area of skin; Flat, discoloured area of skin; Macula; Maculae; Macular Lesion</td></tr>
|
||
<tr><td><span class="bold">SNOMED CT: </span></td>
|
||
<td>Macule (112629002); Macula (112629002); Maculae (112629002)</td></tr>
|
||
<tr><td colspan="2" class="small"> </td></tr><tr><td>HPO:</td>
|
||
<td><a target="_blank" title="Human Phenotype Ontology" href="https://hpo.jax.org/app/browse/term/HP:0012733">HP:0012733</a></td></tr>
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</tbody></table></div><div class="rprt-body jig-ncbiinpagenav" data-jigconfig="smoothScroll: false, gotoTopLink: true, gotoTopLinkText: '', gotoTopLinkAttrs: {'title': 'Go to the top of the page'},allHeadingLevels: ['h1'], topOfPageTOC: true, tocId: 'my-toc'"><div id="rprt-tabs-1" class="rprt-tab"><div id="tb-termsProp-1"><div class="leftCol mgCol"><div>
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<div class="portlet mgSection" id="ID_100">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Definition">Definition</h1><a sid="100" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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||
<div class="portlet_content ln">A flat, distinct, discolored area of skin less than 1 cm wide that does not involve any change in the thickness or texture of the skin. [from <a title="Human Phenotype Ontology" href="http://www.human-phenotype-ontology.org" class="defSource" target="_blank">HPO</a>]</div>
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</div>
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<div class="portlet mgSection" id="ID_118">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Term_Hierarchy">Term Hierarchy</h1><a sid="118" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln HierarchyGTR"><div class="jig-ncbitabs"><ul><li><a href="#tabGTR">GTR</a></li><li><a href="#tabMGEN">MeSH</a></li></ul><div id="tabGTR"><div class="search_result"><div class="rprts"><div class="chiclet_legend"><span class="chiclet_list" style="position:static;"><span title="Clinical test" class="chiclet Ccolor round">C</span><span>Clinical test, </span><span title="Research test" class="chiclet Rcolor round">R</span><span>Research test, </span><span title="OMIM" class="chiclet Ocolor ">O</span><span>OMIM, </span><span title="GeneReview" class="chiclet Gcolor">G</span><span><em>GeneReviews</em>, </span><span title="ClinVar" class="chiclet Vcolor">V</span><span>ClinVar </span></span></div><div id="hierarchy" class="margin_t1"><div class="ds_tree"><ul><li class="matched_ds"><span class="TLline">Macule</span></li></ul></div></div></div></div></div><div id="tabMGEN"><div class="ds_tree"><ul><li><span class="TLline"><a href="/medgen/21047" ref="tree=MeSH" title="MedGen record for Pathological Conditions, Signs and Symptoms">Pathological Conditions, Signs and Symptoms</a></span><ul><li><span class="TLline"><a href="/medgen/19974" ref="tree=MeSH" title="MedGen record for Clinical finding">Clinical finding</a></span><ul><li><span class="TLline"><a href="/medgen/761917" ref="tree=MeSH" title="MedGen record for Sign or Symptom">Sign or Symptom</a></span><ul><li><span class="TLline"><a href="/medgen/232646" ref="tree=MeSH" title="MedGen record for Integumentary System Signs and Symptoms">Integumentary System Signs and Symptoms</a></span><ul><li><span class="matched_ds">Macule</span><ul><li><span class="TLline"><a href="/medgen/1390597" ref="tree=MeSH" title="MedGen record for Erythematous macule">Erythematous macule</a></span></li><li><span class="TLline"><a href="/medgen/1864369" ref="tree=MeSH" title="MedGen record for Gottron sign">Gottron sign</a></span></li><li><span class="TLline"><a href="/medgen/375013" ref="tree=MeSH" title="MedGen record for Hypermelanotic macule">Hypermelanotic macule</a></span><ul><li><span class="TLline"><a href="/medgen/113157" ref="tree=MeSH" title="MedGen record for Cafe-au-lait spot">Cafe-au-lait spot</a></span><ul><li><span class="TLline"><a href="/medgen/396266" ref="tree=MeSH" title="MedGen record for Cafe au lait spots, multiple">Cafe au lait spots, multiple</a></span></li><li><span class="TLline"><a href="/medgen/870435" ref="tree=MeSH" title="MedGen record for Few cafe-au-lait spots">Few cafe-au-lait spots</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/870720" ref="tree=MeSH" title="MedGen record for Large cafe-au-lait macules with irregular margins">Large cafe-au-lait macules with irregular margins</a></span></li><li><span class="TLline"><a href="/medgen/870439" ref="tree=MeSH" title="MedGen record for Macular hyperpigmented dermopathy">Macular hyperpigmented dermopathy</a></span></li><li><span class="TLline"><a href="/medgen/75591" ref="tree=MeSH" title="MedGen record for Mongolian blue spot">Mongolian blue spot</a></span></li><li><span class="TLline"><a href="/medgen/272242" ref="tree=MeSH" title="MedGen record for Multiple lentigines">Multiple lentigines</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/870431" ref="tree=MeSH" title="MedGen record for Hyperpigmented/hypopigmented macules">Hyperpigmented/hypopigmented macules</a></span><ul><li><span class="TLline"><a href="/medgen/342032" ref="tree=MeSH" title="MedGen record for Discrete 2 to 5-mm hyper- and hypopigmented macules">Discrete 2 to 5-mm hyper- and hypopigmented macules</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/760487" ref="tree=MeSH" title="MedGen record for Hypopigmented macule">Hypopigmented macule</a></span><ul><li><span class="TLline"><a href="/medgen/377093" ref="tree=MeSH" title="MedGen record for Confetti-like hypopigmented macules">Confetti-like hypopigmented macules</a></span></li><li><span class="TLline"><a href="/medgen/869790" ref="tree=MeSH" title="MedGen record for Hypomelanotic macule">Hypomelanotic macule</a></span><ul><li><span class="TLline"><a href="/medgen/892949" ref="tree=MeSH" title="MedGen record for Ash-leaf spot">Ash-leaf spot</a></span></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></div></div></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_112">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Conditions_with_this_feature">Conditions with this feature</h1><a sid="112" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln clinfeat">
|
||
<div class="divPopper rprt" id="rdis_98363"><div><strong>Reticulate acropigmentation of Kitamura</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>98363</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0406811</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">A rare, genetic, hyperpigmentation of the skin disease characterized by childhood to adulthood-onset of reticulate, slightly depressed, sharply demarcated, brown, macular skin lesions without hypopigmentation, affecting the dorsa of the hands and feet, and, occasionally, progressing to involve limbs, neck, forehead and/or trunk. Interrupted dermatoglyphics and palmoplantar pits may be additionally observed. Histologically, hyperpigmented lesions show slightly elongated and thinned rete ridges, mild hyperkeratosis without parakeratosis and absence of incontinentia pigmenti.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/98363">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_164078"><div><strong>Schimke immuno-osseous dysplasia</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>164078</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information."><span class="highlight" style="background-color:">C0877024</span></a></dd><dt><span class="dotprefix"> •</span></dt><dd>Congenital Abnormality</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Schimke immunoosseous dysplasia (SIOD) is characterized by spondyloepiphyseal dysplasia (SED) resulting in short stature, nephropathy, and T cell deficiency. Radiographic manifestations of SED include ovoid and mildly flattened vertebral bodies, small ilia with shallow dysplastic acetabular fossae, and small deformed capital femoral epiphyses. Nearly all affected individuals have progressive steroid-resistant nephropathy, usually developing within five years of the diagnosis of growth failure and terminating with end-stage renal disease. The majority of tested individuals have T cell deficiency and an associated risk for opportunistic infection, a common cause of death. SIOD involves a spectrum that ranges from an infantile or severe early-onset form with a greater risk of death during childhood to a juvenile or milder later-onset form with likely survival into adulthood if renal disease is appropriately treated.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/164078">Condition Record</a></div></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_98363" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Reticulate acropigmentation of Kitamura</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_164078" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Schimke immuno-osseous dysplasia</a></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_105">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Professional_guidelines">Professional guidelines</h1><a sid="105" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">PubMed<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpPM"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/38610078">Janus kinase inhibitors and the changing landscape of vitiligo management: a scoping review.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Utama A,
|
||
Wijesinghe R,
|
||
Thng S</span><br />
|
||
<span class="medgenPMjournal">Int J Dermatol</span>
|
||
2024 Aug;63(8):1020-1035.
|
||
Epub 2024 Apr 12
|
||
doi: 10.1111/ijd.17157.
|
||
<span class="bold">PMID: </span><a href="/pubmed/38610078" target="_blank">38610078</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/29683288">Lentigo maligna: diagnosis and treatment.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">De Luca EV,
|
||
Perino F,
|
||
Di Stefani A,
|
||
Coco V,
|
||
Fossati B,
|
||
Peris K</span><br />
|
||
<span class="medgenPMjournal">G Ital Dermatol Venereol</span>
|
||
2020 Apr;155(2):179-189.
|
||
Epub 2018 Apr 19
|
||
doi: 10.23736/S0392-0488.18.06003-0.
|
||
<span class="bold">PMID: </span><a href="/pubmed/29683288" target="_blank">29683288</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/26724277">Vitiligo: Pathogenesis, clinical variants and treatment approaches.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Iannella G,
|
||
Greco A,
|
||
Didona D,
|
||
Didona B,
|
||
Granata G,
|
||
Manno A,
|
||
Pasquariello B,
|
||
Magliulo G</span><br />
|
||
<span class="medgenPMjournal">Autoimmun Rev</span>
|
||
2016 Apr;15(4):335-43.
|
||
Epub 2015 Dec 23
|
||
doi: 10.1016/j.autrev.2015.12.006.
|
||
<span class="bold">PMID: </span><a href="/pubmed/26724277" target="_blank">26724277</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(%22macule%22%5Btiab%3A~0%5D)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">See all (20)</a></div></div>
|
||
</div>
|
||
<div class="display-none help-popup" id="guidelinesHelpPM">These guidelines are articles in PubMed that match specific search criteria developed by MedGen to capture the most relevant practice guidelines. This list may not be comprehensive and may include broader topics as well. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div><div class="display-none help-popup" id="guidelinesHelpCurated">These guidelines are manually curated by the MedGen team
|
||
to supplement articles available in PubMed. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div>
|
||
<div class="portlet mgSection" id="ID_103">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_clinical_studies">Recent clinical studies</h1><a sid="103" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">Etiology</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/38610078">Janus kinase inhibitors and the changing landscape of vitiligo management: a scoping review.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Utama A,
|
||
Wijesinghe R,
|
||
Thng S</span><br />
|
||
<span class="medgenPMjournal">Int J Dermatol</span>
|
||
2024 Aug;63(8):1020-1035.
|
||
Epub 2024 Apr 12
|
||
doi: 10.1111/ijd.17157.
|
||
<span class="bold">PMID: </span><a href="/pubmed/38610078" target="_blank">38610078</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/29243804">Notalgia paresthetica: a review for dermatologists.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Howard M,
|
||
Sahhar L,
|
||
Andrews F,
|
||
Bergman R,
|
||
Gin D</span><br />
|
||
<span class="medgenPMjournal">Int J Dermatol</span>
|
||
2018 Apr;57(4):388-392.
|
||
Epub 2017 Dec 15
|
||
doi: 10.1111/ijd.13853.
|
||
<span class="bold">PMID: </span><a href="/pubmed/29243804" target="_blank">29243804</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/28225967">Synchronous melanomas arising within nevus spilus.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Brito MH,
|
||
Dionísio CS,
|
||
Fernandes CM,
|
||
Ferreira JC,
|
||
Rosa MJ,
|
||
Garcia MM</span><br />
|
||
<span class="medgenPMjournal">An Bras Dermatol</span>
|
||
2017 Jan-Feb;92(1):107-109.
|
||
doi: 10.1590/abd1806-4841.20175230.
|
||
<span class="bold">PMID: </span><a href="/pubmed/28225967" target="_blank">28225967</a><a href="/pmc/articles/PMC5312189" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/8420497">Clinical classification of cases of toxic epidermal necrolysis, Stevens-Johnson syndrome, and erythema multiforme.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Bastuji-Garin S,
|
||
Rzany B,
|
||
Stern RS,
|
||
Shear NH,
|
||
Naldi L,
|
||
Roujeau JC</span><br />
|
||
<span class="medgenPMjournal">Arch Dermatol</span>
|
||
1993 Jan;129(1):92-6.
|
||
<span class="bold">PMID: </span><a href="/pubmed/8420497" target="_blank">8420497</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/1066601">The labial melanotic macule.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Weathers DR,
|
||
Corio RL,
|
||
Crawford BE,
|
||
Giansanti JS,
|
||
Page LR</span><br />
|
||
<span class="medgenPMjournal">Oral Surg Oral Med Oral Pathol</span>
|
||
1976 Aug;42(2):196-205.
|
||
doi: 10.1016/0030-4220(76)90124-9.
|
||
<span class="bold">PMID: </span><a href="/pubmed/1066601" target="_blank">1066601</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Macule%22%20AND%20Etiology%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (114)</a></div><h3 class="subhead">Diagnosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/37239810">McCune-Albright Syndrome: A Case Report and Review of Literature.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Nicolaides NC,
|
||
Kontou M,
|
||
Vasilakis IA,
|
||
Binou M,
|
||
Lykopoulou E,
|
||
Kanaka-Gantenbein C</span><br />
|
||
<span class="medgenPMjournal">Int J Mol Sci</span>
|
||
2023 May 9;24(10)
|
||
doi: 10.3390/ijms24108464.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37239810" target="_blank">37239810</a><a href="/pmc/articles/PMC10218573" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/33236823">Oral manifestations of COVID-19 disease: A review article.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Iranmanesh B,
|
||
Khalili M,
|
||
Amiri R,
|
||
Zartab H,
|
||
Aflatoonian M</span><br />
|
||
<span class="medgenPMjournal">Dermatol Ther</span>
|
||
2021 Jan;34(1):e14578.
|
||
Epub 2020 Dec 13
|
||
doi: 10.1111/dth.14578.
|
||
<span class="bold">PMID: </span><a href="/pubmed/33236823" target="_blank">33236823</a><a href="/pmc/articles/PMC7744903" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/31880637">A Blue-Gray Macule on the Back: Answer.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Aderibigbe O,
|
||
Groft-MacFarlane C,
|
||
Chu EY</span><br />
|
||
<span class="medgenPMjournal">Am J Dermatopathol</span>
|
||
2020 Jan;42(1):65.
|
||
doi: 10.1097/DAD.0000000000001267.
|
||
<span class="bold">PMID: </span><a href="/pubmed/31880637" target="_blank">31880637</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/31831114">Café au Lait Macules and Associated Genetic Syndromes.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Anderson S</span><br />
|
||
<span class="medgenPMjournal">J Pediatr Health Care</span>
|
||
2020 Jan-Feb;34(1):71-81.
|
||
doi: 10.1016/j.pedhc.2019.05.001.
|
||
<span class="bold">PMID: </span><a href="/pubmed/31831114" target="_blank">31831114</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/30671761">Black and Brown: Non-neoplastic Pigmentation of the Oral Mucosa.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Rosebush MS,
|
||
Briody AN,
|
||
Cordell KG</span><br />
|
||
<span class="medgenPMjournal">Head Neck Pathol</span>
|
||
2019 Mar;13(1):47-55.
|
||
Epub 2019 Jan 22
|
||
doi: 10.1007/s12105-018-0980-9.
|
||
<span class="bold">PMID: </span><a href="/pubmed/30671761" target="_blank">30671761</a><a href="/pmc/articles/PMC6405786" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Macule%22%20AND%20Diagnosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (307)</a></div><h3 class="subhead">Therapy</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/38816329">Fixed drug eruption secondary to etoricoxib.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Rawlings N,
|
||
Joshi S,
|
||
Sandison A,
|
||
Carey B</span><br />
|
||
<span class="medgenPMjournal">Br J Oral Maxillofac Surg</span>
|
||
2024 Jul;62(6):571-574.
|
||
Epub 2024 May 15
|
||
doi: 10.1016/j.bjoms.2024.05.001.
|
||
<span class="bold">PMID: </span><a href="/pubmed/38816329" target="_blank">38816329</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/24464902">Prosthesis selection.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Diaz-Ledezma C,
|
||
Parvizi J,
|
||
Zhou Y,
|
||
Antoci V,
|
||
Ducheyne P,
|
||
Freiberg A,
|
||
Rangel GG,
|
||
Han SB,
|
||
Hickok N,
|
||
Higuera C,
|
||
Ketonis C,
|
||
Korkusuz F,
|
||
Kruczynski J,
|
||
Macule F,
|
||
Markuszewski J,
|
||
Marín-Peña O,
|
||
Nathwani D,
|
||
Noble P,
|
||
Ong K,
|
||
Ono N,
|
||
Parvizi MS,
|
||
Post Z,
|
||
Rivero-Boschert S,
|
||
Schaer T,
|
||
Shapiro I</span><br />
|
||
<span class="medgenPMjournal">J Orthop Res</span>
|
||
2014 Jan;32 Suppl 1:S90-7.
|
||
doi: 10.1002/jor.22552.
|
||
<span class="bold">PMID: </span><a href="/pubmed/24464902" target="_blank">24464902</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/24360496">Prosthesis selection.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Diaz-Ledezma C,
|
||
Parvizi J,
|
||
Zhou Y,
|
||
Antoci V,
|
||
Ducheyne P,
|
||
Freiberg A,
|
||
Garcia Rangel G,
|
||
Han SB,
|
||
Hickok N,
|
||
Higuera C,
|
||
Ketonis C,
|
||
Korkusuz F,
|
||
Kruczynski J,
|
||
Macule F,
|
||
Markuszewski J,
|
||
Marín-Peña O,
|
||
Nathwani D,
|
||
Noble P,
|
||
Ong K,
|
||
Ono N,
|
||
Parvizi MS,
|
||
Post Z,
|
||
Rivero-Boschert S,
|
||
Schaer T,
|
||
Shapiro I</span><br />
|
||
<span class="medgenPMjournal">J Arthroplasty</span>
|
||
2014 Feb;29(2 Suppl):71-6.
|
||
Epub 2013 Dec 17
|
||
doi: 10.1016/j.arth.2013.09.039.
|
||
<span class="bold">PMID: </span><a href="/pubmed/24360496" target="_blank">24360496</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/20695869">PlayStation purpura.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Robertson SJ,
|
||
Leonard J,
|
||
Chamberlain AJ</span><br />
|
||
<span class="medgenPMjournal">Australas J Dermatol</span>
|
||
2010 Aug;51(3):220-2.
|
||
doi: 10.1111/j.1440-0960.2010.00652.x.
|
||
<span class="bold">PMID: </span><a href="/pubmed/20695869" target="_blank">20695869</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/15999870">Tick-borne disease.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Bratton RL,
|
||
Corey R</span><br />
|
||
<span class="medgenPMjournal">Am Fam Physician</span>
|
||
2005 Jun 15;71(12):2323-30.
|
||
<span class="bold">PMID: </span><a href="/pubmed/15999870" target="_blank">15999870</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Macule%22%20AND%20Therapy%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (127)</a></div><h3 class="subhead">Prognosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/30942103">Notalgia paresthetica: treatment review and algorithmic approach.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Ansari A,
|
||
Weinstein D,
|
||
Sami N</span><br />
|
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<span class="medgenPMjournal">J Dermatolog Treat</span>
|
||
2020 Jun;31(4):424-432.
|
||
Epub 2019 Apr 25
|
||
doi: 10.1080/09546634.2019.1603360.
|
||
<span class="bold">PMID: </span><a href="/pubmed/30942103" target="_blank">30942103</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/29450847">Laugier-Hunziker Syndrome Presenting with Metachronous Melanoacanthomas.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Zaki H,
|
||
Sabharwal A,
|
||
Kramer J,
|
||
Aguirre A</span><br />
|
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<span class="medgenPMjournal">Head Neck Pathol</span>
|
||
2019 Jun;13(2):257-263.
|
||
Epub 2018 Feb 15
|
||
doi: 10.1007/s12105-018-0897-3.
|
||
<span class="bold">PMID: </span><a href="/pubmed/29450847" target="_blank">29450847</a><a href="/pmc/articles/PMC6514033" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/29454601">Cross-linked polyethylene does not reduce wear in total knee arthroplasty.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Lasurt-Bachs S,
|
||
Torner P,
|
||
Maculé F,
|
||
Prats E,
|
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Menéndez-García F,
|
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Ríos-Guillermo J,
|
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Torrents A</span><br />
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<span class="medgenPMjournal">Rev Esp Cir Ortop Traumatol (Engl Ed)</span>
|
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2018 May-Jun;62(3):197-203.
|
||
Epub 2018 Feb 14
|
||
doi: 10.1016/j.recot.2017.11.004.
|
||
<span class="bold">PMID: </span><a href="/pubmed/29454601" target="_blank">29454601</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/15097945">Persistent blue nevus simulating melanoma.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Muñoz C,
|
||
Quintero A,
|
||
Sánchez JL,
|
||
Ruiz-Santiago H</span><br />
|
||
<span class="medgenPMjournal">J Am Acad Dermatol</span>
|
||
2004 May;50(5 Suppl):S118-20.
|
||
doi: 10.1016/j.jaad.2003.09.022.
|
||
<span class="bold">PMID: </span><a href="/pubmed/15097945" target="_blank">15097945</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/1066601">The labial melanotic macule.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Weathers DR,
|
||
Corio RL,
|
||
Crawford BE,
|
||
Giansanti JS,
|
||
Page LR</span><br />
|
||
<span class="medgenPMjournal">Oral Surg Oral Med Oral Pathol</span>
|
||
1976 Aug;42(2):196-205.
|
||
doi: 10.1016/0030-4220(76)90124-9.
|
||
<span class="bold">PMID: </span><a href="/pubmed/1066601" target="_blank">1066601</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Macule%22%20AND%20Prognosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (72)</a></div><h3 class="subhead">Clinical prediction guides</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/36048560">Melanin accumulation in dermal stem cells deteriorates their exosome-mediated skin basement membrane construction in solar lentigo.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Miyachi K,
|
||
Yamada T,
|
||
Sanada A,
|
||
Inoue Y,
|
||
Hasebe Y,
|
||
Arima M,
|
||
Iwata Y,
|
||
Hasegawa S,
|
||
Sugiura K,
|
||
Akamatsu H</span><br />
|
||
<span class="medgenPMjournal">Exp Dermatol</span>
|
||
2022 Dec;31(12):1881-1890.
|
||
Epub 2022 Sep 1
|
||
doi: 10.1111/exd.14667.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36048560" target="_blank">36048560</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/20695869">PlayStation purpura.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Robertson SJ,
|
||
Leonard J,
|
||
Chamberlain AJ</span><br />
|
||
<span class="medgenPMjournal">Australas J Dermatol</span>
|
||
2010 Aug;51(3):220-2.
|
||
doi: 10.1111/j.1440-0960.2010.00652.x.
|
||
<span class="bold">PMID: </span><a href="/pubmed/20695869" target="_blank">20695869</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/7971559">Agminated lentiginosis: case report and review of the literature.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Micali G,
|
||
Nasca MR,
|
||
Innocenzi D,
|
||
Lembo D</span><br />
|
||
<span class="medgenPMjournal">Pediatr Dermatol</span>
|
||
1994 Sep;11(3):241-5.
|
||
doi: 10.1111/j.1525-1470.1994.tb00594.x.
|
||
<span class="bold">PMID: </span><a href="/pubmed/7971559" target="_blank">7971559</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/7059225">The involuting lichenoid plaque.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Berman A,
|
||
Herszenson S,
|
||
Winkelmann RK</span><br />
|
||
<span class="medgenPMjournal">Arch Dermatol</span>
|
||
1982 Feb;118(2):93-6.
|
||
<span class="bold">PMID: </span><a href="/pubmed/7059225" target="_blank">7059225</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/1271148">Transient neonatal pustular melanosis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Ramamurthy RS,
|
||
Reveri M,
|
||
Esterly NB,
|
||
Fretzin DF,
|
||
Pildes RS</span><br />
|
||
<span class="medgenPMjournal">J Pediatr</span>
|
||
1976 May;88(5):831-5.
|
||
doi: 10.1016/s0022-3476(76)81126-2.
|
||
<span class="bold">PMID: </span><a href="/pubmed/1271148" target="_blank">1271148</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Macule%22%20AND%20Clinical%20prediction%20guides%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (110)</a></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_104">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_systematic_reviews">Recent systematic reviews</h1><a sid="104" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln">
|
||
<div class="nl"><a target="_blank" href="/pubmed/36877453">Autonomous growth hormone secretion due to McCune Albright syndrome in paediatric age group: an ominous triad.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Jayant SS,
|
||
Walia R,
|
||
Gupta R,
|
||
Pal R,
|
||
Chaudhary S,
|
||
Agrawal K,
|
||
Rastogi A,
|
||
Bhattacharya A,
|
||
Dutta P,
|
||
Bhadada SK,
|
||
Bhansali A</span><br />
|
||
<span class="medgenPMjournal">Endocrine</span>
|
||
2023 Jul;81(1):149-159.
|
||
Epub 2023 Mar 6
|
||
doi: 10.1007/s12020-023-03333-7.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36877453" target="_blank">36877453</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/34551420">Skin Eruptions in Acute Hemorrhagic Edema of Young Children: Systematic Review of the Literature.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Bronz G,
|
||
Rinoldi PO,
|
||
Lavagno C,
|
||
Bianchetti MG,
|
||
Lava SAG,
|
||
Vanoni F,
|
||
Milani GP,
|
||
Terrani I,
|
||
Ferrarini A</span><br />
|
||
<span class="medgenPMjournal">Dermatology</span>
|
||
2022;238(3):397-403.
|
||
Epub 2021 Sep 22
|
||
doi: 10.1159/000519009.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34551420" target="_blank">34551420</a><a href="/pmc/articles/PMC9153327" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Macule%22%20AND%20systematic%5Bsb%5D%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (2)</a></div></div>
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|
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|
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<div class="supplemental col three_col last">
|
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<h2 class="offscreen_noflow">Supplemental Content</h2>
|
||
|
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|
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Table_of_contents">Table of contents</h1><a sid="113" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="portlet_content ln"><ul><li><a href="https://clinicaltrials.gov/search?cond=Macule" target="_blank">ClinicalTrials.gov</a></li></ul></div>
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Practice_guidelines">Practice guidelines</h1><a sid="121" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="portlet_content ln"><ul class="a_poppers"><li><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(%22macule%22%5Btiab%3A~0%5D)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">PubMed</a><div class="help-popup">See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div></li><li><a target="_blank" href="/books/?term=((%22clinical%20guidelines%22%5BResource%20Type%5D)%20OR%20%22practice%20guideline%22%5BPublication%20Type%5D)%20AND%20(%22Macule%22)">Bookshelf</a><div class="help-popup">See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div></li></ul></div>
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<a href="/pubmed/clinical?term=Macule" ref="ncbi_uid=&discoId=gtr_reviews&linkpos=1&linkpostotal=2" target="_blank">PubMed Clinical Queries</a>
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