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<meta name="keywords" content="C0014733, disease or syndrome, erysipelas, patch of erysipelas, st. anthony's fire, autosomal dominant, autosomal recessive, birth defects, chromosomal disease, chromosome, clinical features, clinical findings, clinical genetics, clinical recommendations, clinvar, congenital chromosomal disease, consumer genetic resources, cytogenetic location, disease characteristics, disease definitions, disease descriptions, disease ontology, disease synonyms, disease vocabulary, dysmorphology, entrez, familial disease, gene, gene-disease relationship, genereviews, genetic disease, genetic disorder, genetic terminology, genetic testing registry, genetics home reference, genomic disease, gtr, hereditary disease, heritable disease, hpo, human phenotype ontology, inherited disease, management guidelines, maternal inheritance, medgen, medical genetics, medical subject headings, mesh, mitochondrial inheritance, mode of inheritance, national center for biotechnology information, national institutes of health, national library of medicine, ncbi, nih, nlm, omim, ordo, orphanet, paternal inheritance, phenome, position statements, professional practice guidelines, rare disease, reference sequence, refseq, snomed ct, syndrome, undiagnosed diseases, x-linked recessive" /><meta name="description" content="Increased susceptibility to erysipelas, as manifested by a medical history of repeated episodes of erysipelas, which is a superficial infection of the skin, typically involving the lymphatic system." /><meta name="robots" content="index,nofollow,noarchive" />
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<!--
UID=41855
ConceptID=C0014733
-->
<!--imgCountBooks = 0--><h1 class="medgenTitle"><div class="MedGenTitleText">Erysipelas</div></h1><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>41855</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C0014733</a></dd><dt><span class="dotprefix"></span></dt><dd>Disease or Syndrome</dd></dl></div></div><table class="medgenTable"><tbody><tr><td>Synonyms:</td>
<td>erysipelas; Patch of erysipelas; St. Anthony's Fire</td></tr>
<tr><td><span class="bold">SNOMED CT: </span></td>
<td>Erysipelas (44653001); Patch of erysipelas (44653001)</td></tr>
<tr><td colspan="2" class="small"> </td></tr><tr><td>HPO:</td>
<td><a target="_blank" title="Human Phenotype Ontology" href="https://hpo.jax.org/app/browse/term/HP:0001055">HP:0001055</a></td></tr>
<tr><td>Monarch Initiative:</td>
<td><a href="https://monarchinitiative.org/disease/MONDO:0001266" target="_blank">MONDO:0001266</a></td></tr>
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Definition">Definition</h1><a sid="100" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln">Increased susceptibility to erysipelas, as manifested by a medical history of repeated episodes of erysipelas, which is a superficial infection of the skin, typically involving the lymphatic system. [from <a title="Human Phenotype Ontology" href="http://www.human-phenotype-ontology.org" class="defSource" target="_blank">HPO</a>]</div>
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Term_Hierarchy">Term Hierarchy</h1><a sid="118" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln HierarchyGTR"><div class="jig-ncbitabs"><ul><li><a href="#tabGTR">GTR</a></li><li><a href="#tabMGEN">MeSH</a></li></ul><div id="tabGTR"><div class="search_result"><div class="rprts"><div class="chiclet_legend"><span class="chiclet_list" style="position:static;"><span title="Clinical test" class="chiclet Ccolor round">C</span><span>Clinical test,  </span><span title="Research test" class="chiclet Rcolor round">R</span><span>Research test,  </span><span title="OMIM" class="chiclet Ocolor ">O</span><span>OMIM,  </span><span title="GeneReview" class="chiclet Gcolor">G</span><span><em>GeneReviews</em>,  </span><span title="ClinVar" class="chiclet Vcolor">V</span><span>ClinVar  </span></span></div><div id="hierarchy" class="margin_t1"><div class="ds_tree"><ul><li class="matched_ds"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C0014733[DISCUI]&amp;test_type=Clinical" ref="ncbi_uid=41855">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet unavailable" title="OMIM">O</span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet unavailable" title="ClinVar">V</span></span><span class="TLline">Erysipelas</span></li></ul></div></div></div></div></div><div id="tabMGEN"><div class="ds_tree"><ul><li><span class="TLline"><a href="/medgen/19974" ref="tree=MeSH" title="MedGen record for Clinical finding">Clinical finding</a></span><ul><li><span class="TLline"><a href="/medgen/232191" ref="tree=MeSH" title="MedGen record for Finding by Cause">Finding by Cause</a></span><ul><li><span class="TLline"><a href="/medgen/811352" ref="tree=MeSH" title="MedGen record for Infection">Infection</a></span><ul><li><span class="TLline"><a href="/medgen/2161" ref="tree=MeSH" title="MedGen record for Bacterial Infections and Mycoses">Bacterial Infections and Mycoses</a></span><ul><li><span class="TLline"><a href="/medgen/14012" ref="tree=MeSH" title="MedGen record for Bacterial infectious disease">Bacterial infectious disease</a></span><ul><li><span class="TLline"><a href="/medgen/56470" ref="tree=MeSH" title="MedGen record for Bacterial infection of skin">Bacterial infection of skin</a></span><ul><li><span class="matched_ds">Erysipelas</span></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></div></div></div></div>
</div>
<div class="portlet mgSection" id="ID_112">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Conditions_with_this_feature">Conditions with this feature</h1><a sid="112" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln clinfeat">
<div class="divPopper rprt" id="rdis_45811"><div><strong>Familial Mediterranean fever</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>45811</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C0031069</a></dd><dt><span class="dotprefix"></span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
<div class="spaceAbove">Familial Mediterranean fever (FMF) is divided into two phenotypes: type 1 and type 2. FMF type 1 is characterized by recurrent short episodes of inflammation and serositis including fever, peritonitis, synovitis, pleuritis, and, rarely, pericarditis and meningitis. The symptoms and severity vary among affected individuals, sometimes even among members of the same family. Amyloidosis, which can lead to kidney failure, is the most severe complication, if untreated. FMF type 2 is characterized by amyloidosis as the first clinical manifestation of FMF in an otherwise asymptomatic individual.</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/45811">Condition Record</a></div></div>
<div class="divPopper rprt" id="rdis_78658"><div><strong>Cholestasis-edema syndrome, Norwegian type</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>78658</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C0268314</a></dd><dt><span class="dotprefix"></span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
<div class="spaceAbove">Cholestasis-lymphedema syndrome is a rare genetic disorder characterized by neonatal intrahepatic cholestasis, often lessening and becoming intermittent with age, and severe chronic lymphedema which mainly affects the lower limbs. Patients often present with fat malabsorption leading to failure to thrive, fat soluble vitamin deficiency with bleeding, rickets, and neuropathy. In 25% of cases, cirrhosis occurs during childhood or later in life.</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/78658">Condition Record</a></div></div>
<div class="divPopper rprt" id="rdis_226899"><div><strong>TNF receptor-associated periodic fever syndrome (TRAPS)</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>226899</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C1275126</a></dd><dt><span class="dotprefix"></span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
<div class="spaceAbove">TNF receptor-associated periodic fever syndrome (TRAPS) is characterized by episodes of inflammation typically occurring every four to six weeks and lasting between five and 25 days. Flares may be prompted by stress, infection, trauma, hormonal changes, and vaccination. Symptoms may include fever, abdominal pain, arthralgia, myalgia, migratory rash, and eye inflammation, with variable severity. Symptoms often begin in early childhood (median age 4.3 years), though symptom onset can occur later in life. During a flare, acute-phase reactants such as C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), and serum amyloid A are typically elevated. Generally, acute-phase reactants stabilize between flares but may remain somewhat elevated even in the absence of clinical symptoms. AA amyloidosis, the most severe sequela of TRAPS, can largely be avoided with adequate treatment. Proteinuria and kidney failure occur in 80%-90% of affected individuals with amyloidosis, while intestinal, thyroid, myocardium, liver, and spleen deposits are less common.</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/226899">Condition Record</a></div></div>
<div class="divPopper rprt" id="rdis_341987"><div><strong>Familial Mediterranean fever, autosomal dominant</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>341987</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information."><span class="highlight" style="background-color:">C1851347</span></a></dd><dt><span class="dotprefix"></span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
<div class="spaceAbove">Familial Mediterranean fever (FMF) is divided into two phenotypes: type 1 and type 2. FMF type 1 is characterized by recurrent short episodes of inflammation and serositis including fever, peritonitis, synovitis, pleuritis, and, rarely, pericarditis and meningitis. The symptoms and severity vary among affected individuals, sometimes even among members of the same family. Amyloidosis, which can lead to kidney failure, is the most severe complication, if untreated. FMF type 2 is characterized by amyloidosis as the first clinical manifestation of FMF in an otherwise asymptomatic individual.</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/341987">Condition Record</a></div></div>
<div class="divPopper rprt" id="rdis_816655"><div><strong>Hereditary sclerosing poikiloderma with tendon and pulmonary involvement</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>816655</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C3810325</a></dd><dt><span class="dotprefix"></span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
<div class="spaceAbove">Hereditary fibrosing poikiloderma with tendon contractures, myopathy, and pulmonary fibrosis (POIKTMP) is characterized by the skin findings of poikiloderma (typically beginning in the first six months and mainly localized to the face), hypohidrosis with heat intolerance, mild lymphedema of the extremities, chronic erythematous and scaly skin lesions on the extremities, sclerosis of the digits, and mild palmoplantar keratoderma. Scalp hair, eyelashes, and/or eyebrows are typically sparse. Muscle contractures are usually seen in childhood and can be present as early as age two years. The majority of affected individuals develop progressive weakness of the proximal and distal muscles of all four limbs. Some adults develop progressive interstitial pulmonary fibrosis, which can be life threatening within three to four years after respiratory symptoms appear. Other features are exocrine pancreatic insufficiency, liver impairment, hematologic abnormalities, relative short stature, and cataract.</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/816655">Condition Record</a></div></div>
<div class="divPopper rprt" id="rdis_860487"><div><strong>Hennekam lymphangiectasia-lymphedema syndrome 1</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>860487</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C4012050</a></dd><dt><span class="dotprefix"></span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
<div class="spaceAbove">Hennekam lymphangiectasia-lymphedema syndrome (HKLLS1) is an autosomal recessive disorder characterized by generalized lymphatic dysplasia affecting various organs, including the intestinal tract, pericardium, and limbs. Additional features of the disorder include facial dysmorphism and cognitive impairment (summary by Alders et al., 2014).&#13; Genetic Heterogeneity of Hennekam Lymphangiectasia-Lymphedema Syndrome&#13; See also HKLLS2 (616006), caused by mutation in the FAT4 gene (612411) on chromosome 4q28, and HKLLS3 (618154), caused by mutation in the ADAMTS3 gene (605011) on chromosome 4q13.</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/860487">Condition Record</a></div></div>
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_78658" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Cholestasis-edema syndrome, Norwegian type</a></div>
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_45811" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Familial Mediterranean fever</a></div>
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_341987" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Familial Mediterranean fever, autosomal dominant</a></div>
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_860487" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Hennekam lymphangiectasia-lymphedema syndrome 1</a></div>
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_816655" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Hereditary sclerosing poikiloderma with tendon and pulmonary involvement</a></div>
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_226899" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">TNF receptor-associated periodic fever syndrome (TRAPS)</a></div></div>
</div>
<div class="portlet mgSection" id="ID_105">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Professional_guidelines">Professional guidelines</h1><a sid="105" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln"><h3 class="subhead">PubMed<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpPM"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3>
<div class="nl"><a target="_blank" href="/pubmed/32745638">Route and duration of antibiotic therapy in acute cellulitis: A systematic review and meta-analysis of the effectiveness and harms of antibiotic treatment.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Cross ELA,
Jordan H,
Godfrey R,
Onakpoya IJ,
Shears A,
Fidler K,
Peto TEA,
Walker AS,
Llewelyn MJ</span><br />
<span class="medgenPMjournal">J Infect</span>
2020 Oct;81(4):521-531.
Epub 2020 Jul 31
doi: 10.1016/j.jinf.2020.07.030.
<span class="bold">PMID: </span><a href="/pubmed/32745638" target="_blank">32745638</a></div>
<div class="nl"><a target="_blank" href="/pubmed/30777258">Common Community-acquired Bacterial Skin and Soft-tissue Infections in Children: an Intersociety Consensus on Impetigo, Abscess, and Cellulitis Treatment.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Galli L,
Venturini E,
Bassi A,
Gattinara GC,
Chiappini E,
Defilippi C,
Diociaiuti A,
Esposito S,
Garazzino S,
Giannattasio A,
Krzysztofiak A,
Latorre S,
Lo Vecchio A,
Marchisio P,
Montagnani C,
Nicolini G,
Novelli A,
Rossolini GM,
Tersigni C,
Villani A,
El Hachem M,
Neri I;
Italian Pediatric Infectious Diseases Society;
Italian Pediatric Dermatology Society</span><br />
<span class="medgenPMjournal">Clin Ther</span>
2019 Mar;41(3):532-551.e17.
Epub 2019 Feb 15
doi: 10.1016/j.clinthera.2019.01.010.
<span class="bold">PMID: </span><a href="/pubmed/30777258" target="_blank">30777258</a></div>
<div class="nl"><a target="_blank" href="/pubmed/30390916">An Update on the Treatment and Management of Cellulitis.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Ortiz-Lazo E,
Arriagada-Egnen C,
Poehls C,
Concha-Rogazy M</span><br />
<span class="medgenPMjournal">Actas Dermosifiliogr (Engl Ed)</span>
2019 Mar;110(2):124-130.
Epub 2018 Oct 31
doi: 10.1016/j.ad.2018.07.010.
<span class="bold">PMID: </span><a href="/pubmed/30390916" target="_blank">30390916</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(%22erysipelas%22%5Btiab%3A~0%5D)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">See all (80)</a></div></div>
</div>
<div class="display-none help-popup" id="guidelinesHelpPM">These guidelines are articles in PubMed that match specific search criteria developed by MedGen to capture the most relevant practice guidelines. This list may not be comprehensive and may include broader topics as well. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div><div class="display-none help-popup" id="guidelinesHelpCurated">These guidelines are manually curated by the MedGen team
to supplement articles available in PubMed. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div>
<div class="portlet mgSection" id="ID_103">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_clinical_studies">Recent clinical studies</h1><a sid="103" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln"><h3 class="subhead">Etiology</h3>
<div class="nl"><a target="_blank" href="/pubmed/35039323">Cutaneous signs and mechanisms of inflammasomopathies.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Borst C,
Symmank D,
Drach M,
Weninger W</span><br />
<span class="medgenPMjournal">Ann Rheum Dis</span>
2022 Apr;81(4):454-465.
Epub 2022 Jan 17
doi: 10.1136/annrheumdis-2021-220977.
<span class="bold">PMID: </span><a href="/pubmed/35039323" target="_blank">35039323</a></div>
<div class="nl"><a target="_blank" href="/pubmed/33494874">Cellulitis.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Bystritsky RJ</span><br />
<span class="medgenPMjournal">Infect Dis Clin North Am</span>
2021 Mar;35(1):49-60.
doi: 10.1016/j.idc.2020.10.002.
<span class="bold">PMID: </span><a href="/pubmed/33494874" target="_blank">33494874</a></div>
<div class="nl"><a target="_blank" href="/pubmed/26612370">Bacterial Skin Infections.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Ibrahim F,
Khan T,
Pujalte GG</span><br />
<span class="medgenPMjournal">Prim Care</span>
2015 Dec;42(4):485-99.
doi: 10.1016/j.pop.2015.08.001.
<span class="bold">PMID: </span><a href="/pubmed/26612370" target="_blank">26612370</a></div>
<div class="nl"><a target="_blank" href="/pubmed/22570033">Pyodermitis.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Empinotti JC,
Uyeda H,
Ruaro RT,
Galhardo AP,
Bonatto DC</span><br />
<span class="medgenPMjournal">An Bras Dermatol</span>
2012 Mar-Apr;87(2):277-84.
doi: 10.1590/s0365-05962012000200013.
<span class="bold">PMID: </span><a href="/pubmed/22570033" target="_blank">22570033</a></div>
<div class="nl"><a target="_blank" href="/pubmed/12230764">Cellulitis and erysipelas.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Morris A</span><br />
<span class="medgenPMjournal">Clin Evid</span>
2002 Jun;(7):1483-7.
<span class="bold">PMID: </span><a href="/pubmed/12230764" target="_blank">12230764</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Erysipelas%22%20AND%20Etiology%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (406)</a></div><h3 class="subhead">Diagnosis</h3>
<div class="nl"><a target="_blank" href="/pubmed/33494874">Cellulitis.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Bystritsky RJ</span><br />
<span class="medgenPMjournal">Infect Dis Clin North Am</span>
2021 Mar;35(1):49-60.
doi: 10.1016/j.idc.2020.10.002.
<span class="bold">PMID: </span><a href="/pubmed/33494874" target="_blank">33494874</a></div>
<div class="nl"><a target="_blank" href="/pubmed/30304305">Erysipelatoid Carcinoma.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Miguel TS,
Costa DAD,
Almeida APM,
Pino LCM,
Goldemberg DC,
Miguel BS,
Coelho Filho SCH</span><br />
<span class="medgenPMjournal">Rev Assoc Med Bras (1992)</span>
2018 Jun;64(6):492-497.
doi: 10.1590/1806-9282.64.06.492.
<span class="bold">PMID: </span><a href="/pubmed/30304305" target="_blank">30304305</a></div>
<div class="nl"><a target="_blank" href="/pubmed/30115333">Skin Infections.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Clebak KT,
Malone MA</span><br />
<span class="medgenPMjournal">Prim Care</span>
2018 Sep;45(3):433-454.
doi: 10.1016/j.pop.2018.05.004.
<span class="bold">PMID: </span><a href="/pubmed/30115333" target="_blank">30115333</a></div>
<div class="nl"><a target="_blank" href="/pubmed/27767278">Wells syndrome.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Weins AB,
Biedermann T,
Weiss T,
Weiss JM</span><br />
<span class="medgenPMjournal">J Dtsch Dermatol Ges</span>
2016 Oct;14(10):989-993.
doi: 10.1111/ddg.13132.
<span class="bold">PMID: </span><a href="/pubmed/27767278" target="_blank">27767278</a></div>
<div class="nl"><a target="_blank" href="/pubmed/22570033">Pyodermitis.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Empinotti JC,
Uyeda H,
Ruaro RT,
Galhardo AP,
Bonatto DC</span><br />
<span class="medgenPMjournal">An Bras Dermatol</span>
2012 Mar-Apr;87(2):277-84.
doi: 10.1590/s0365-05962012000200013.
<span class="bold">PMID: </span><a href="/pubmed/22570033" target="_blank">22570033</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Erysipelas%22%20AND%20Diagnosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (433)</a></div><h3 class="subhead">Therapy</h3>
<div class="nl"><a target="_blank" href="/pubmed/33494874">Cellulitis.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Bystritsky RJ</span><br />
<span class="medgenPMjournal">Infect Dis Clin North Am</span>
2021 Mar;35(1):49-60.
doi: 10.1016/j.idc.2020.10.002.
<span class="bold">PMID: </span><a href="/pubmed/33494874" target="_blank">33494874</a></div>
<div class="nl"><a target="_blank" href="/pubmed/27767278">Wells syndrome.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Weins AB,
Biedermann T,
Weiss T,
Weiss JM</span><br />
<span class="medgenPMjournal">J Dtsch Dermatol Ges</span>
2016 Oct;14(10):989-993.
doi: 10.1111/ddg.13132.
<span class="bold">PMID: </span><a href="/pubmed/27767278" target="_blank">27767278</a></div>
<div class="nl"><a target="_blank" href="/pubmed/26612370">Bacterial Skin Infections.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Ibrahim F,
Khan T,
Pujalte GG</span><br />
<span class="medgenPMjournal">Prim Care</span>
2015 Dec;42(4):485-99.
doi: 10.1016/j.pop.2015.08.001.
<span class="bold">PMID: </span><a href="/pubmed/26612370" target="_blank">26612370</a></div>
<div class="nl"><a target="_blank" href="/pubmed/15366207">Cellulitis and erysipelas.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Morris A</span><br />
<span class="medgenPMjournal">Clin Evid</span>
2003 Jun;(9):1804-9.
<span class="bold">PMID: </span><a href="/pubmed/15366207" target="_blank">15366207</a></div>
<div class="nl"><a target="_blank" href="/pubmed/12230764">Cellulitis and erysipelas.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Morris A</span><br />
<span class="medgenPMjournal">Clin Evid</span>
2002 Jun;(7):1483-7.
<span class="bold">PMID: </span><a href="/pubmed/12230764" target="_blank">12230764</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Erysipelas%22%20AND%20Therapy%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (358)</a></div><h3 class="subhead">Prognosis</h3>
<div class="nl"><a target="_blank" href="/pubmed/32513395">Cutaneous leishmaniasis: A great imitator.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Gurel MS,
Tekin B,
Uzun S</span><br />
<span class="medgenPMjournal">Clin Dermatol</span>
2020 Mar-Apr;38(2):140-151.
Epub 2019 Oct 24
doi: 10.1016/j.clindermatol.2019.10.008.
<span class="bold">PMID: </span><a href="/pubmed/32513395" target="_blank">32513395</a></div>
<div class="nl"><a target="_blank" href="/pubmed/27767278">Wells syndrome.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Weins AB,
Biedermann T,
Weiss T,
Weiss JM</span><br />
<span class="medgenPMjournal">J Dtsch Dermatol Ges</span>
2016 Oct;14(10):989-993.
doi: 10.1111/ddg.13132.
<span class="bold">PMID: </span><a href="/pubmed/27767278" target="_blank">27767278</a></div>
<div class="nl"><a target="_blank" href="/pubmed/27587513">The Charcot foot: pathophysiology, diagnosis and classification.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Trieb K</span><br />
<span class="medgenPMjournal">Bone Joint J</span>
2016 Sep;98-B(9):1155-9.
doi: 10.1302/0301-620X.98B9.37038.
<span class="bold">PMID: </span><a href="/pubmed/27587513" target="_blank">27587513</a></div>
<div class="nl"><a target="_blank" href="/pubmed/25441467">Rarely seen infections.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Amer M,
Amer A</span><br />
<span class="medgenPMjournal">Clin Dermatol</span>
2014 Nov-Dec;32(6):744-51.
Epub 2014 Mar 2
doi: 10.1016/j.clindermatol.2014.02.013.
<span class="bold">PMID: </span><a href="/pubmed/25441467" target="_blank">25441467</a></div>
<div class="nl"><a target="_blank" href="/pubmed/7046527">Necrotizing fasciitis.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Brenner BE,
Vitullo M,
Simon RR</span><br />
<span class="medgenPMjournal">Ann Emerg Med</span>
1982 Jul;11(7):384-6.
doi: 10.1016/s0196-0644(82)80370-3.
<span class="bold">PMID: </span><a href="/pubmed/7046527" target="_blank">7046527</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Erysipelas%22%20AND%20Prognosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (193)</a></div><h3 class="subhead">Clinical prediction guides</h3>
<div class="nl"><a target="_blank" href="/pubmed/32745638">Route and duration of antibiotic therapy in acute cellulitis: A systematic review and meta-analysis of the effectiveness and harms of antibiotic treatment.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Cross ELA,
Jordan H,
Godfrey R,
Onakpoya IJ,
Shears A,
Fidler K,
Peto TEA,
Walker AS,
Llewelyn MJ</span><br />
<span class="medgenPMjournal">J Infect</span>
2020 Oct;81(4):521-531.
Epub 2020 Jul 31
doi: 10.1016/j.jinf.2020.07.030.
<span class="bold">PMID: </span><a href="/pubmed/32745638" target="_blank">32745638</a></div>
<div class="nl"><a target="_blank" href="/pubmed/30777258">Common Community-acquired Bacterial Skin and Soft-tissue Infections in Children: an Intersociety Consensus on Impetigo, Abscess, and Cellulitis Treatment.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Galli L,
Venturini E,
Bassi A,
Gattinara GC,
Chiappini E,
Defilippi C,
Diociaiuti A,
Esposito S,
Garazzino S,
Giannattasio A,
Krzysztofiak A,
Latorre S,
Lo Vecchio A,
Marchisio P,
Montagnani C,
Nicolini G,
Novelli A,
Rossolini GM,
Tersigni C,
Villani A,
El Hachem M,
Neri I;
Italian Pediatric Infectious Diseases Society;
Italian Pediatric Dermatology Society</span><br />
<span class="medgenPMjournal">Clin Ther</span>
2019 Mar;41(3):532-551.e17.
Epub 2019 Feb 15
doi: 10.1016/j.clinthera.2019.01.010.
<span class="bold">PMID: </span><a href="/pubmed/30777258" target="_blank">30777258</a></div>
<div class="nl"><a target="_blank" href="/pubmed/27767278">Wells syndrome.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Weins AB,
Biedermann T,
Weiss T,
Weiss JM</span><br />
<span class="medgenPMjournal">J Dtsch Dermatol Ges</span>
2016 Oct;14(10):989-993.
doi: 10.1111/ddg.13132.
<span class="bold">PMID: </span><a href="/pubmed/27767278" target="_blank">27767278</a></div>
<div class="nl"><a target="_blank" href="/pubmed/18281661">Sentinel node dissection is safe in the treatment of early-stage vulvar cancer.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Van der Zee AG,
Oonk MH,
De Hullu JA,
Ansink AC,
Vergote I,
Verheijen RH,
Maggioni A,
Gaarenstroom KN,
Baldwin PJ,
Van Dorst EB,
Van der Velden J,
Hermans RH,
van der Putten H,
Drouin P,
Schneider A,
Sluiter WJ</span><br />
<span class="medgenPMjournal">J Clin Oncol</span>
2008 Feb 20;26(6):884-9.
doi: 10.1200/JCO.2007.14.0566.
<span class="bold">PMID: </span><a href="/pubmed/18281661" target="_blank">18281661</a></div>
<div class="nl"><a target="_blank" href="/pubmed/3997339">Erysipelas. Changing faces.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Ronnen M,
Suster S,
Schewach-Millet M,
Modan M</span><br />
<span class="medgenPMjournal">Int J Dermatol</span>
1985 Apr;24(3):169-72.
doi: 10.1111/j.1365-4362.1985.tb05750.x.
<span class="bold">PMID: </span><a href="/pubmed/3997339" target="_blank">3997339</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Erysipelas%22%20AND%20Clinical%20prediction%20guides%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (176)</a></div></div>
</div>
<div class="portlet mgSection" id="ID_104">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_systematic_reviews">Recent systematic reviews</h1><a sid="104" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln">
<div class="nl"><a target="_blank" href="/pubmed/37231210">Misdiagnosis of Uncomplicated Cellulitis: a Systematic Review and Meta-analysis.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Nightingale R,
Yadav K,
Hamill L,
Glasziou P,
Scott AM,
Clark J,
Keijzers G</span><br />
<span class="medgenPMjournal">J Gen Intern Med</span>
2023 Aug;38(10):2396-2404.
Epub 2023 May 25
doi: 10.1007/s11606-023-08229-w.
<span class="bold">PMID: </span><a href="/pubmed/37231210" target="_blank">37231210</a><a href="/pmc/articles/PMC10406744" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/32745638">Route and duration of antibiotic therapy in acute cellulitis: A systematic review and meta-analysis of the effectiveness and harms of antibiotic treatment.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Cross ELA,
Jordan H,
Godfrey R,
Onakpoya IJ,
Shears A,
Fidler K,
Peto TEA,
Walker AS,
Llewelyn MJ</span><br />
<span class="medgenPMjournal">J Infect</span>
2020 Oct;81(4):521-531.
Epub 2020 Jul 31
doi: 10.1016/j.jinf.2020.07.030.
<span class="bold">PMID: </span><a href="/pubmed/32745638" target="_blank">32745638</a></div>
<div class="nl"><a target="_blank" href="/pubmed/28631307">Interventions for the prevention of recurrent erysipelas and cellulitis.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Dalal A,
Eskin-Schwartz M,
Mimouni D,
Ray S,
Days W,
Hodak E,
Leibovici L,
Paul M</span><br />
<span class="medgenPMjournal">Cochrane Database Syst Rev</span>
2017 Jun 20;6(6):CD009758.
doi: 10.1002/14651858.CD009758.pub2.
<span class="bold">PMID: </span><a href="/pubmed/28631307" target="_blank">28631307</a><a href="/pmc/articles/PMC6481501" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/22101078">A systematic review of bacteremias in cellulitis and erysipelas.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Gunderson CG,
Martinello RA</span><br />
<span class="medgenPMjournal">J Infect</span>
2012 Feb;64(2):148-55.
Epub 2011 Nov 11
doi: 10.1016/j.jinf.2011.11.004.
<span class="bold">PMID: </span><a href="/pubmed/22101078" target="_blank">22101078</a></div>
<div class="nl"><a target="_blank" href="/pubmed/19450336">Cellulitis and erysipelas.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Morris AD</span><br />
<span class="medgenPMjournal">BMJ Clin Evid</span>
2008 Jan 2;2008
<span class="bold">PMID: </span><a href="/pubmed/19450336" target="_blank">19450336</a><a href="/pmc/articles/PMC2907977" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Erysipelas%22%20AND%20systematic%5Bsb%5D%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (22)</a></div></div>
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