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<!--
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||
UID=412612
|
||
ConceptID=C2748698
|
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-->
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<!--imgCountBooks = 0--><h1 class="medgenTitle"><div class="MedGenTitleText">Portal inflammation</div></h1><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>412612</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C2748698</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Pathologic Function</dd></dl></div></div><table class="medgenTable"><tbody><tr><td>Synonym:</td>
|
||
<td>Hepatic portal inflammation</td></tr>
|
||
<tr><td colspan="2" class="small"> </td></tr><tr><td>HPO:</td>
|
||
<td><a target="_blank" title="Human Phenotype Ontology" href="https://hpo.jax.org/app/browse/term/HP:0033196">HP:0033196</a></td></tr>
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<div class="portlet mgSection" id="ID_100">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Definition">Definition</h1><a sid="100" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln">Infiltration of portal fields by inflammatory cells. [from <a title="Human Phenotype Ontology" href="http://www.human-phenotype-ontology.org" class="defSource" target="_blank">HPO</a>]</div>
|
||
</div>
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<div class="portlet mgSection" id="ID_118">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Term_Hierarchy">Term Hierarchy</h1><a sid="118" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
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<div class="portlet_content ln HierarchyGTR"><div class="jig-ncbitabs"><ul><li><a href="#tabGTR">GTR</a></li><li><a href="#tabMGEN">MeSH</a></li></ul><div id="tabGTR"><div class="search_result"><div class="rprts"><div class="chiclet_legend"><span class="chiclet_list" style="position:static;"><span title="Clinical test" class="chiclet Ccolor round">C</span><span>Clinical test, </span><span title="Research test" class="chiclet Rcolor round">R</span><span>Research test, </span><span title="OMIM" class="chiclet Ocolor ">O</span><span>OMIM, </span><span title="GeneReview" class="chiclet Gcolor">G</span><span><em>GeneReviews</em>, </span><span title="ClinVar" class="chiclet Vcolor">V</span><span>ClinVar </span></span></div><div id="hierarchy" class="margin_t1"><div class="ds_tree"><ul><li class="matched_ds"><span class="chiclet_list"><span class="chiclet unavailable round" title="Clinical test">C</span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet unavailable" title="OMIM">O</span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet unavailable" title="ClinVar">V</span></span><span class="TLline">Portal inflammation</span></li></ul></div></div></div></div></div><div id="tabMGEN"><div class="ds_tree"><ul><li><span class="TLline"><a href="/medgen/3828" ref="tree=MeSH" title="MedGen record for Disorder of digestive system">Disorder of digestive system</a></span><ul><li><span class="TLline"><a href="/medgen/78584" ref="tree=MeSH" title="MedGen record for Abnormality of the digestive system">Abnormality of the digestive system</a></span><ul><li><span class="TLline"><a href="/medgen/867396" ref="tree=MeSH" title="MedGen record for Abnormality of the abdominal organs">Abnormality of the abdominal organs</a></span><ul><li><span class="TLline"><a href="/medgen/893061" ref="tree=MeSH" title="MedGen record for Abnormality of the liver">Abnormality of the liver</a></span><ul><li><span class="TLline"><a href="/medgen/184895" ref="tree=MeSH" title="MedGen record for Abnormality of the biliary system">Abnormality of the biliary system</a></span><ul><li><span class="matched_ds">Portal inflammation</span></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></div></div></div></div>
|
||
</div>
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||
|
||
<div class="portlet mgSection" id="ID_112">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Conditions_with_this_feature">Conditions with this feature</h1><a sid="112" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="portlet_content ln clinfeat">
|
||
<div class="divPopper rprt" id="rdis_208652"><div><strong>Cholestasis-pigmentary retinopathy-cleft palate syndrome</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>208652</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0795969</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">MED12-related disorders include the phenotypes of FG syndrome type 1 (FGS1), Lujan syndrome (LS), X-linked Ohdo syndrome (XLOS), Hardikar syndrome (HS), and nonspecific intellectual disability (NSID). FGS1 and LS share the clinical findings of cognitive impairment, hypotonia, and abnormalities of the corpus callosum. FGS1 is further characterized by absolute or relative macrocephaly, tall forehead, downslanted palpebral fissures, small and simple ears, constipation and/or anal anomalies, broad thumbs and halluces, and characteristic behavior. LS is further characterized by large head, tall thin body habitus, long thin face, prominent nasal bridge, high narrow palate, and short philtrum. Carrier females in families with FGS1 and LS are typically unaffected. XLOS is characterized by intellectual disability, blepharophimosis, and facial coarsening. HS has been described in females with cleft lip and/or cleft palate, biliary and liver anomalies, intestinal malrotation, pigmentary retinopathy, and coarctation of the aorta. Developmental and cognitive concerns have not been reported in females with HS. Pathogenic variants in MED12 have been reported in an increasing number of males and females with NSID, with affected individuals often having clinical features identified in other MED12-related disorders.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/208652">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_350276"><div><strong>Citrullinemia type II</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>350276</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1863844</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Citrin deficiency can manifest in newborns or infants as neonatal intrahepatic cholestasis caused by citrin deficiency (NICCD), in older children as failure to thrive and dyslipidemia caused by citrin deficiency (FTTDCD), and in adults as recurrent hyperammonemia with neuropsychiatric symptoms in citrullinemia type II (CTLN2). Often citrin deficiency is characterized by strong preference for protein-rich and/or lipid-rich foods and aversion to carbohydrate-rich foods. NICCD. Children younger than age one year have a history of low birth weight with growth restriction and transient intrahepatic cholestasis, hepatomegaly, diffuse fatty liver, and parenchymal cellular infiltration associated with hepatic fibrosis, variable liver dysfunction, hypoproteinemia, decreased coagulation factors, hemolytic anemia, and/or hypoglycemia. NICCD is generally not severe and symptoms often resolve by age one year with appropriate treatment, although liver transplantation has been required in rare instances. FTTDCD. Beyond age one year, many children with citrin deficiency develop a protein-rich and/or lipid-rich food preference and aversion to carbohydrate-rich foods. Clinical abnormalities may include growth restriction, hypoglycemia, pancreatitis, severe fatigue, anorexia, and impaired quality of life. Laboratory changes are dyslipidemia, increased lactate-to-pyruvate ratio, higher levels of urinary oxidative stress markers, and considerable deviation in tricarboxylic acid (TCA) cycle metabolites. One or more decades later, some individuals with NICCD or FTTDCD develop CTLN2. CTLN2. Presentation is sudden and usually between ages 20 and 50 years. Manifestations are recurrent hyperammonemia with neuropsychiatric symptoms including nocturnal delirium, aggression, irritability, hyperactivity, delusions, disorientation, restlessness, drowsiness, loss of memory, flapping tremor, convulsive seizures, and coma. Symptoms are often provoked by alcohol and sugar intake, medication, and/or surgery. Affected individuals may or may not have a prior history of NICCD or FTTDCD.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/350276">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_356333"><div><strong>Progressive familial intrahepatic cholestasis type 3</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>356333</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1865643</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">The signs and symptoms of PFIC2 are typically related to liver disease only; however, these signs and symptoms tend to be more severe than those experienced by people with PFIC1. People with PFIC2 often develop liver failure within the first few years of life. Additionally, affected individuals are at increased risk of developing a type of liver cancer called hepatocellular carcinoma.\n\nIn addition to signs and symptoms related to liver disease, people with PFIC1 may have short stature, deafness, diarrhea, inflammation of the pancreas (pancreatitis), and low levels of fat-soluble vitamins (vitamins A, D, E, and K) in the blood. Affected individuals typically develop liver failure before adulthood.\n\nThere are three known types of PFIC: PFIC1, PFIC2, and PFIC3. The types are also sometimes described as shortages of particular proteins needed for normal liver function. Each type has a different genetic cause.\n\nMost people with PFIC3 have signs and symptoms related to liver disease only. Signs and symptoms of PFIC3 usually do not appear until later in infancy or early childhood; rarely, people are diagnosed in early adulthood. Liver failure can occur in childhood or adulthood in people with PFIC3.\n\nSigns and symptoms of PFIC typically begin in infancy and are related to bile buildup and liver disease. Specifically, affected individuals experience severe itching, yellowing of the skin and whites of the eyes (jaundice), failure to gain weight and grow at the expected rate (failure to thrive), high blood pressure in the vein that supplies blood to the liver (portal hypertension), and an enlarged liver and spleen (hepatosplenomegaly).\n\nProgressive familial intrahepatic cholestasis (PFIC) is a disorder that causes progressive liver disease, which typically leads to liver failure. In people with PFIC, liver cells are less able to secrete a digestive fluid called bile. The buildup of bile in liver cells causes liver disease in affected individuals.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/356333">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_760527"><div><strong>Low phospholipid associated cholelithiasis</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>760527</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C2609268</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">In general, gallbladder disease (GBD) is one of the major digestive diseases. GBD prevalence is particularly high in some minority populations in the United States, including Native and Mexican Americans. Gallstones composed of cholesterol (cholelithiasis) are the common manifestations of GBD in western countries, including the United States. Most people with gallstones remain asymptomatic through their lifetimes; however, it is estimated that approximately 10 to 50% of individuals eventually develop symptoms. Significant risk factors associated with GBD are age, female sex, obesity (especially central obesity), lipids, diet, parity, type 2 diabetes (125853), medications, and Mexican American ethnicity. GBD appears to be strongly related to the metabolic syndrome (605552) and/or its major components, such as hyperinsulinism, dyslipidemia, and abdominal adiposity (Boland et al., 2002; Tsai et al., 2004). Infection, specifically by Helicobacter, has been implicated in cholelithiasis and cholecystitis (Silva et al., 2003; Maurer et al., 2005). Low phospholipid-associated cholelithiasis is a specific form of gallbladder disease characterized by young-adult onset of chronic cholestasis with intrahepatic sludge and cholesterol cholelithiasis. Affected individuals have recurrence of the disorder after cholecystectomy and show a favorable response to treatment with ursodeoxycholic acid (UDCA) (summary by Pasmant et al., 2012). Mutation in the ABCB4 gene can cause a spectrum of related diseases, including the more severe progressive familial intrahepatic cholestasis-3 (PFIC3; 602347), intrahepatic cholestasis of pregnancy-3 (ICP3; 614972), andoral contraceptive-induced cholestasis (OCIC; see 614972). Genetic Heterogeneity of Gallbladder Disease Two major susceptibility loci for symptomatic gallbladder disease have been identified on chromosome 1p in Mexican Americans (GBD2, 609918; GBD3, 609919). In addition, variations in the ABCG8 gene (605460) on chromosome 2p21 confer susceptibility to gallbladder disease (GBD4; 611465).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/760527">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_462412"><div><strong>FADD-related immunodeficiency</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>462412</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C3151062</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Immunodeficiency-90 with encephalopathy, functional hyposplenia, and hepatic dysfunction (IMD90) is a autosomal recessive complex immunologic disorder with systemic manifestations in addition to primary immunodeficiency. Affected individuals usually present in infancy or early childhood with recurrent fevers and bacterial or viral infections associated with central nervous system symptoms, including irritability, drowsiness, variable seizures, and white matter abnormalities on brain imaging. There is also liver involvement and functional hyposplenism, causing increased susceptibility to invasive pneumococcal infection, which may be fatal. Susceptibility to viral infections likely results from impaired interferon immunity, and bacterial infections likely result from splenic dysfunction. A subset of patients have congenital cardiac malformations. Most individuals demonstrate developmental delay and speech delay. Laboratory findings in affected individuals are similar to those seen in autoimmune lymphoproliferative syndrome (ALPS; 601859), including high-circulating CD4-/CD8-/TCR-alpha-beta+ (double-negative) T-cell (DNT) counts, and elevated IL10 (124092) and FASL (TNFSF6; 134638) levels, but the clinical features are somewhat different from ALPS: massive lymphadenopathy and autoimmune features are not observed in IMD90 (summary by Bolze et al., 2010, Savic et al., 2015 and Kohn et al., 2020).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/462412">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_1823968"><div><strong>Liver disease, severe congenital</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1823968</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C5774195</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Severe congenital liver disease (SCOLIV) is an autosomal recessive disorder characterized by the onset of progressive hepatic dysfunction usually in the first years of life. Affected individuals show feeding difficulties with failure to thrive and features such as jaundice, hepatomegaly, and abdominal distension. Laboratory workup is consistent with hepatic insufficiency and may also show coagulation defects, anemia, or metabolic disturbances. Cirrhosis and hypernodularity are commonly observed on liver biopsy. Many patients die of liver failure in early childhood (Moreno Traspas et al., 2022).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1823968">Condition Record</a></div></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_208652" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Cholestasis-pigmentary retinopathy-cleft palate syndrome</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_350276" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Citrullinemia type II</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_462412" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">FADD-related immunodeficiency</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1823968" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Liver disease, severe congenital</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_760527" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Low phospholipid associated cholelithiasis</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_356333" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Progressive familial intrahepatic cholestasis type 3</a></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_105">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Professional_guidelines">Professional guidelines</h1><a sid="105" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">PubMed<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpPM"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/34482313">Immune-related cholangitis induced by immune checkpoint inhibitors: a systematic review of clinical features and management.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Pi B,
|
||
Wang J,
|
||
Tong Y,
|
||
Yang Q,
|
||
Lv F,
|
||
Yu Y</span><br />
|
||
<span class="medgenPMjournal">Eur J Gastroenterol Hepatol</span>
|
||
2021 Dec 1;33(1S Suppl 1):e858-e867.
|
||
doi: 10.1097/MEG.0000000000002280.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34482313" target="_blank">34482313</a><a href="/pmc/articles/PMC8734631" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/33492001">Primary biliary cholangitis: treatment.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Cazzagon N,
|
||
Floreani A</span><br />
|
||
<span class="medgenPMjournal">Curr Opin Gastroenterol</span>
|
||
2021 Mar 1;37(2):99-104.
|
||
doi: 10.1097/MOG.0000000000000708.
|
||
<span class="bold">PMID: </span><a href="/pubmed/33492001" target="_blank">33492001</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/17143938">Concept on the pathogenesis and treatment of primary biliary cirrhosis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Reshetnyak VI</span><br />
|
||
<span class="medgenPMjournal">World J Gastroenterol</span>
|
||
2006 Dec 7;12(45):7250-62.
|
||
doi: 10.3748/wjg.v12.i45.7250.
|
||
<span class="bold">PMID: </span><a href="/pubmed/17143938" target="_blank">17143938</a><a href="/pmc/articles/PMC4087480" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(%22portal%20inflammation%22%5Btiab%3A~0%5D)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">See all (36)</a></div></div>
|
||
</div>
|
||
<div class="display-none help-popup" id="guidelinesHelpPM">These guidelines are articles in PubMed that match specific search criteria developed by MedGen to capture the most relevant practice guidelines. This list may not be comprehensive and may include broader topics as well. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div><div class="display-none help-popup" id="guidelinesHelpCurated">These guidelines are manually curated by the MedGen team
|
||
to supplement articles available in PubMed. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div>
|
||
<div class="portlet mgSection" id="ID_103">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_clinical_studies">Recent clinical studies</h1><a sid="103" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">Etiology</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/39461995">Circulating thrombospondin 2 as a predictor of hepatocellular carcinoma in hepatitis B patients undergoing nucleos(t)ide analog therapy.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Okumura T,
|
||
Kimura T,
|
||
Ichikawa Y,
|
||
Iwadare T,
|
||
Wakabayashi SI,
|
||
Kobayashi H,
|
||
Yamashita Y,
|
||
Uchida T,
|
||
Pydi SP,
|
||
Tanaka N,
|
||
Umemura T</span><br />
|
||
<span class="medgenPMjournal">Sci Rep</span>
|
||
2024 Oct 26;14(1):25584.
|
||
doi: 10.1038/s41598-024-76532-5.
|
||
<span class="bold">PMID: </span><a href="/pubmed/39461995" target="_blank">39461995</a><a href="/pmc/articles/PMC11513038" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/35948927">Clinicopathologic features of de novo non-alcoholic steatohepatitis in the post-transplant setting.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Balitzer D,
|
||
Tsai JH,
|
||
Gill RM</span><br />
|
||
<span class="medgenPMjournal">Diagn Pathol</span>
|
||
2022 Aug 10;17(1):65.
|
||
doi: 10.1186/s13000-022-01247-y.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35948927" target="_blank">35948927</a><a href="/pmc/articles/PMC9367095" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/33492001">Primary biliary cholangitis: treatment.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Cazzagon N,
|
||
Floreani A</span><br />
|
||
<span class="medgenPMjournal">Curr Opin Gastroenterol</span>
|
||
2021 Mar 1;37(2):99-104.
|
||
doi: 10.1097/MOG.0000000000000708.
|
||
<span class="bold">PMID: </span><a href="/pubmed/33492001" target="_blank">33492001</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/18242499">Cholestasis induced by total parenteral nutrition.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Guglielmi FW,
|
||
Regano N,
|
||
Mazzuoli S,
|
||
Fregnan S,
|
||
Leogrande G,
|
||
Guglielmi A,
|
||
Merli M,
|
||
Pironi L,
|
||
Penco JM,
|
||
Francavilla A</span><br />
|
||
<span class="medgenPMjournal">Clin Liver Dis</span>
|
||
2008 Feb;12(1):97-110, viii.
|
||
doi: 10.1016/j.cld.2007.11.004.
|
||
<span class="bold">PMID: </span><a href="/pubmed/18242499" target="_blank">18242499</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/10484010">Nonalcoholic steatohepatitis: a proposal for grading and staging the histological lesions.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Brunt EM,
|
||
Janney CG,
|
||
Di Bisceglie AM,
|
||
Neuschwander-Tetri BA,
|
||
Bacon BR</span><br />
|
||
<span class="medgenPMjournal">Am J Gastroenterol</span>
|
||
1999 Sep;94(9):2467-74.
|
||
doi: 10.1111/j.1572-0241.1999.01377.x.
|
||
<span class="bold">PMID: </span><a href="/pubmed/10484010" target="_blank">10484010</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Portal%20inflammation%22%20AND%20Etiology%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (288)</a></div><h3 class="subhead">Diagnosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/33660295">Diagnostic and therapeutic caveats in Griscelli syndrome.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Castaño-Jaramillo LM,
|
||
Lugo-Reyes SO,
|
||
Cruz Muñoz ME,
|
||
Scheffler-Mendoza SC,
|
||
Duran McKinster C,
|
||
Yamazaki-Nakashimada MA,
|
||
Espinosa-Padilla SE,
|
||
Saez-de-Ocariz Gutierrez MDM</span><br />
|
||
<span class="medgenPMjournal">Scand J Immunol</span>
|
||
2021 Jun;93(6):e13034.
|
||
Epub 2021 Mar 20
|
||
doi: 10.1111/sji.13034.
|
||
<span class="bold">PMID: </span><a href="/pubmed/33660295" target="_blank">33660295</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/32536769">Significance of progressive liver fibrosis in pediatric liver transplants: A review of current evidence.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">George M,
|
||
Paci P,
|
||
Taner T</span><br />
|
||
<span class="medgenPMjournal">World J Gastroenterol</span>
|
||
2020 May 7;26(17):1987-1992.
|
||
doi: 10.3748/wjg.v26.i17.1987.
|
||
<span class="bold">PMID: </span><a href="/pubmed/32536769" target="_blank">32536769</a><a href="/pmc/articles/PMC7267692" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/25400438">Histopathology of nonalcoholic fatty liver disease/nonalcoholic steatohepatitis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Takahashi Y,
|
||
Fukusato T</span><br />
|
||
<span class="medgenPMjournal">World J Gastroenterol</span>
|
||
2014 Nov 14;20(42):15539-48.
|
||
doi: 10.3748/wjg.v20.i42.15539.
|
||
<span class="bold">PMID: </span><a href="/pubmed/25400438" target="_blank">25400438</a><a href="/pmc/articles/PMC4229519" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/21609162">Alpha-1-antitrypsin deficiency in early childhood.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Topic A,
|
||
Prokic D,
|
||
Stankovic I</span><br />
|
||
<span class="medgenPMjournal">Fetal Pediatr Pathol</span>
|
||
2011;30(5):312-9.
|
||
Epub 2011 May 24
|
||
doi: 10.3109/15513815.2011.572961.
|
||
<span class="bold">PMID: </span><a href="/pubmed/21609162" target="_blank">21609162</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/18603711">Sickle cell hepatopathy.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Bandyopadhyay R,
|
||
Bandyopadhyay SK,
|
||
Dutta A</span><br />
|
||
<span class="medgenPMjournal">Indian J Pathol Microbiol</span>
|
||
2008 Apr-Jun;51(2):284-5.
|
||
doi: 10.4103/0377-4929.41698.
|
||
<span class="bold">PMID: </span><a href="/pubmed/18603711" target="_blank">18603711</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Portal%20inflammation%22%20AND%20Diagnosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (212)</a></div><h3 class="subhead">Therapy</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/35948927">Clinicopathologic features of de novo non-alcoholic steatohepatitis in the post-transplant setting.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Balitzer D,
|
||
Tsai JH,
|
||
Gill RM</span><br />
|
||
<span class="medgenPMjournal">Diagn Pathol</span>
|
||
2022 Aug 10;17(1):65.
|
||
doi: 10.1186/s13000-022-01247-y.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35948927" target="_blank">35948927</a><a href="/pmc/articles/PMC9367095" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/33492001">Primary biliary cholangitis: treatment.</a></div>
|
||
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<div class="nl"><a target="_blank" href="/pubmed/33660295">Diagnostic and therapeutic caveats in Griscelli syndrome.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Castaño-Jaramillo LM,
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Cruz Muñoz ME,
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Duran McKinster C,
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Yamazaki-Nakashimada MA,
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<div class="nl"><a target="_blank" href="/pubmed/33492001">Primary biliary cholangitis: treatment.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Cazzagon N,
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Floreani A</span><br />
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<span class="medgenPMjournal">Curr Opin Gastroenterol</span>
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2021 Mar 1;37(2):99-104.
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doi: 10.1097/MOG.0000000000000708.
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<span class="bold">PMID: </span><a href="/pubmed/33492001" target="_blank">33492001</a></div>
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<div class="nl"><a target="_blank" href="/pubmed/25400438">Histopathology of nonalcoholic fatty liver disease/nonalcoholic steatohepatitis.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Takahashi Y,
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Fukusato T</span><br />
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|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/18242499">Cholestasis induced by total parenteral nutrition.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Guglielmi FW,
|
||
Regano N,
|
||
Mazzuoli S,
|
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Fregnan S,
|
||
Leogrande G,
|
||
Guglielmi A,
|
||
Merli M,
|
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Pironi L,
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Penco JM,
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Francavilla A</span><br />
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<span class="medgenPMjournal">Clin Liver Dis</span>
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2008 Feb;12(1):97-110, viii.
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doi: 10.1016/j.cld.2007.11.004.
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<span class="bold">PMID: </span><a href="/pubmed/18242499" target="_blank">18242499</a></div>
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<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Portal%20inflammation%22%20AND%20Prognosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (196)</a></div><h3 class="subhead">Clinical prediction guides</h3>
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<div class="nl"><a target="_blank" href="/pubmed/39461995">Circulating thrombospondin 2 as a predictor of hepatocellular carcinoma in hepatitis B patients undergoing nucleos(t)ide analog therapy.</a></div>
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||
<div class="portlet_content ln"><span class="medgenPMauthor">Okumura T,
|
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Kimura T,
|
||
Ichikawa Y,
|
||
Iwadare T,
|
||
Wakabayashi SI,
|
||
Kobayashi H,
|
||
Yamashita Y,
|
||
Uchida T,
|
||
Pydi SP,
|
||
Tanaka N,
|
||
Umemura T</span><br />
|
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<span class="medgenPMjournal">Sci Rep</span>
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2024 Oct 26;14(1):25584.
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doi: 10.1038/s41598-024-76532-5.
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<span class="bold">PMID: </span><a href="/pubmed/39461995" target="_blank">39461995</a><a href="/pmc/articles/PMC11513038" target="_blank" class="PubMedFree">Free PMC Article</a></div>
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<div class="nl"><a target="_blank" href="/pubmed/35023684">Liver Injury and Dysfunction Associated with COVID-19: a Review Article.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Yahia AIO</span><br />
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<span class="medgenPMjournal">Clin Lab</span>
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<div class="nl"><a target="_blank" href="/pubmed/25400438">Histopathology of nonalcoholic fatty liver disease/nonalcoholic steatohepatitis.</a></div>
|
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<div class="portlet_content ln"><span class="medgenPMauthor">Takahashi Y,
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Fukusato T</span><br />
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<span class="medgenPMjournal">World J Gastroenterol</span>
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2014 Nov 14;20(42):15539-48.
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<div class="nl"><a target="_blank" href="/pubmed/19067230">Long-standing mild hypertransaminasaemia caused by congenital disorder of glycosylation (CDG) type IIx.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Calvo PL,
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Pagliardini S,
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Baldi M,
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<div class="nl"><a target="_blank" href="/pubmed/10484010">Nonalcoholic steatohepatitis: a proposal for grading and staging the histological lesions.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Brunt EM,
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Janney CG,
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Di Bisceglie AM,
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<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Portal%20inflammation%22%20AND%20Clinical%20prediction%20guides%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (321)</a></div></div>
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</div>
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||
<div class="portlet mgSection" id="ID_104">
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||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_systematic_reviews">Recent systematic reviews</h1><a sid="104" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="portlet_content ln">
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<div class="nl"><a target="_blank" href="/pubmed/39053026">Histopathological features of idiopathic portal hypertension: A systematic review and meta-analysis.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Malik A,
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Malik S,
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Farooq A,
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Malik MI,
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Javaid S</span><br />
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<span class="bold">PMID: </span><a href="/pubmed/39053026" target="_blank">39053026</a><a href="/pmc/articles/PMC11282518" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/35990246">Prevalence and Significance of Antinuclear Antibodies in Biopsy-Proven Nonalcoholic Fatty Liver Disease: A Systematic Review and Meta-Analysis.</a></div>
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||
<div class="portlet_content ln"><span class="medgenPMauthor">Luo L,
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Ma Q,
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Lin L,
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Wang H,
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Ye J,
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Zhong B</span><br />
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<span class="medgenPMjournal">Dis Markers</span>
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Epub 2022 Aug 12
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doi: 10.1155/2022/8446170.
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<span class="bold">PMID: </span><a href="/pubmed/35990246" target="_blank">35990246</a><a href="/pmc/articles/PMC9391168" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/35236351">Circulating chemerin levels in metabolic-associated fatty liver disease: a systematic review and meta-analysis.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Ren Q,
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Wang H,
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Zeng Y,
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Fang X,
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Wang M,
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Li D,
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Huang W,
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Xu Y</span><br />
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<span class="medgenPMjournal">Lipids Health Dis</span>
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<span class="bold">PMID: </span><a href="/pubmed/35236351" target="_blank">35236351</a><a href="/pmc/articles/PMC8889738" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/33505145">High prevalence of hepatic steatosis and vascular thrombosis in COVID-19: A systematic review and meta-analysis of autopsy data.</a></div>
|
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<div class="portlet_content ln"><span class="medgenPMauthor">Díaz LA,
|
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Idalsoaga F,
|
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Cannistra M,
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Candia R,
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Cabrera D,
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Barrera F,
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Soza A,
|
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Graham R,
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Riquelme A,
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Arrese M,
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Leise MD,
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||
Arab JP</span><br />
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<span class="medgenPMjournal">World J Gastroenterol</span>
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||
2020 Dec 28;26(48):7693-7706.
|
||
doi: 10.3748/wjg.v26.i48.7693.
|
||
<span class="bold">PMID: </span><a href="/pubmed/33505145" target="_blank">33505145</a><a href="/pmc/articles/PMC7789052" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/27775791">Association between irisin and major chronic diseases: a review.</a></div>
|
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<div class="portlet_content ln"><span class="medgenPMauthor">Gouveia MC,
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Vella JP,
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Cafeo FR,
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Affonso Fonseca FL,
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Bacci MR</span><br />
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<span class="medgenPMjournal">Eur Rev Med Pharmacol Sci</span>
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<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Portal%20inflammation%22%20AND%20systematic%5Bsb%5D%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (6)</a></div></div>
|
||
</div>
|
||
</div></div></div></div></div></div></div>
|
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<h2 class="offscreen_noflow">Supplemental Content</h2>
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