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<!--
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UID=39324
|
||
ConceptID=C0085661
|
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<!--imgCountBooks = 0--><h1 class="medgenTitle"><div class="MedGenTitleText">Onycholysis</div></h1><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>39324</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0085661</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div><table class="medgenTable"><tbody><tr><td>Synonym:</td>
|
||
<td>Onycholyses</td></tr>
|
||
<tr><td><span class="bold">SNOMED CT: </span></td>
|
||
<td>Onycholysis (75789001); Separation of nail plate (75789001); Detachment of nail plate (75789001)</td></tr>
|
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<tr><td colspan="2" class="small"> </td></tr><tr><td>HPO:</td>
|
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<td><a target="_blank" title="Human Phenotype Ontology" href="https://hpo.jax.org/app/browse/term/HP:0001806">HP:0001806</a></td></tr>
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Definition">Definition</h1><a sid="100" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="portlet_content ln">Detachment of the nail from the nail bed. [from <a title="Human Phenotype Ontology" href="http://www.human-phenotype-ontology.org" class="defSource" target="_blank">HPO</a>]</div>
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<div class="portlet mgSection" id="ID_118">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Term_Hierarchy">Term Hierarchy</h1><a sid="118" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="portlet_content ln HierarchyGTR"><div class="jig-ncbitabs"><ul><li><a href="#tabGTR">GTR</a></li><li><a href="#tabMGEN">MeSH</a></li></ul><div id="tabGTR"><div class="search_result"><div class="rprts"><div class="chiclet_legend"><span class="chiclet_list" style="position:static;"><span title="Clinical test" class="chiclet Ccolor round">C</span><span>Clinical test, </span><span title="Research test" class="chiclet Rcolor round">R</span><span>Research test, </span><span title="OMIM" class="chiclet Ocolor ">O</span><span>OMIM, </span><span title="GeneReview" class="chiclet Gcolor">G</span><span><em>GeneReviews</em>, </span><span title="ClinVar" class="chiclet Vcolor">V</span><span>ClinVar </span></span></div><div id="hierarchy" class="margin_t1"><div class="ds_tree"><ul><li class="matched_ds"><span class="chiclet_list"><span class="chiclet unavailable round" title="Clinical test">C</span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet unavailable" title="OMIM">O</span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet unavailable" title="ClinVar">V</span></span><span class="TLline">Onycholysis</span></li></ul></div></div></div></div></div><div id="tabMGEN"><div class="ds_tree"><ul><li><span class="TLline"><a href="/medgen/867443" ref="tree=MeSH" title="MedGen record for Phenotypic abnormality">Phenotypic abnormality</a></span><ul><li><span class="TLline"><a href="/medgen/871273" ref="tree=MeSH" title="MedGen record for Abnormality of the integument">Abnormality of the integument</a></span><ul><li><span class="TLline"><a href="/medgen/869100" ref="tree=MeSH" title="MedGen record for Abnormal skin adnexa morphology">Abnormal skin adnexa morphology</a></span><ul><li><span class="TLline"><a href="/medgen/163115" ref="tree=MeSH" title="MedGen record for Abnormal nail morphology">Abnormal nail morphology</a></span><ul><li><span class="TLline"><a href="/medgen/1054580" ref="tree=MeSH" title="MedGen record for Abnormal nail attachment">Abnormal nail attachment</a></span><ul><li><span class="matched_ds">Onycholysis</span><ul><li><span class="TLline"><a href="/medgen/765958" ref="tree=MeSH" title="MedGen record for Onycholysis of fingernails">Onycholysis of fingernails</a></span><ul><li><span class="TLline"><a href="/medgen/870242" ref="tree=MeSH" title="MedGen record for Onycholysis of distal fingernails">Onycholysis of distal fingernails</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/120483" ref="tree=MeSH" title="MedGen record for Onychomadesis">Onychomadesis</a></span></li><li><span class="TLline"><a href="/medgen/867184" ref="tree=MeSH" title="MedGen record for Recurrent loss of toenails and fingernails">Recurrent loss of toenails and fingernails</a></span></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></div></div></div></div>
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||
</div>
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||
<div class="portlet mgSection" id="ID_112">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Conditions_with_this_feature">Conditions with this feature</h1><a sid="112" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="portlet_content ln clinfeat">
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||
<div class="divPopper rprt" id="rdis_56416"><div><strong>Hidrotic ectodermal dysplasia syndrome</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>56416</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information."><span class="highlight" style="background-color:">C0162361</span></a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Hidrotic ectodermal dysplasia 2, or Clouston syndrome (referred to as HED2 throughout this GeneReview) is characterized by a triad of major clinical features including partial-to-complete alopecia, nail dystrophy, and palmoplantar hyperkeratosis. Sweating is preserved and there are usually no dental anomalies. Sparse scalp hair and dysplastic nails are seen early in life. In infancy, scalp hair is fine, sparse, and brittle. Progressive hair loss may lead to total alopecia by puberty. The nails may be milky white in early childhood; they gradually become dystrophic, thick, and distally separated from the nail bed. Palmoplantar keratoderma may develop during childhood and increases in severity with age. Associated features may include cutaneous hyperpigmentation (particularly over the joints) and finger clubbing. The clinical manifestations are highly variable even within the same family.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/56416">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_75669"><div><strong>Familial porphyria cutanea tarda</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>75669</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0268323</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Familial porphyria cutanea tarda (F-PCT) is characterized by: skin findings including blistering over the dorsal aspects of the hands and other sun-exposed areas of skin, skin friability after minor trauma, facial hypertrichosis and hyperpigmentation, and severe thickening of affected skin areas (pseudoscleroderma); and an increased risk for hepatocellular carcinoma (HCC).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/75669">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_96056"><div><strong>Nonsyndromic congenital nail disorder 1</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>96056</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0406443</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Congenital Abnormality</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Many types of nonsyndromic congenital nail disorders (NDNC) have been described. Twenty-nail dystrophy (TND), also known as trachyonychia (from the Greek for 'rough nails'), is an autosomal dominant nail dystrophy characterized by excessive longitudinal striations and numerous superficial pits on the nails, which have a distinctive rough sandpaper-like appearance. Occasionally some nails are spared. The slowly progressive condition is usually apparent at birth and may be self-limiting, with spontaneous resolution in some patients (summary by Sehgal, 2007). TND is referred to here as nonsyndromic congenital nail disorder-1 (NDNC1). Genetic Heterogeneity of Nonsyndromic Congenital Nail Disorders Other nonsyndromic congenital nail disorders include koilonychia (NDNC2; 149300); leukonychia (NDNC3; 151600) caused by mutation in the PLCD1 gene (602142) on chromosome 3p22; anonychia/hyponychia (NDNC4; 206800) caused by mutation in the RSPO4 gene (610673) on chromosome 20p13; partial onycholysis with scleronychia (NDNC5; 164800); anonychia of thumbs with onychodystrophy of other nails (NDNC6; 107000); onychodystrophy mapping to chromosome 17p13 (NDNC7; 605779); toenail dystrophy (NDNC8; 607523) caused by mutation in the COL7A1 gene (120120) on chromosome 3p21; onychodystrophy mapping to chromosome 17q25.1-q25.3 (NDNC9; 614149).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/96056">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_321991"><div><strong>Naxos disease</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>321991</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1832600</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Naxos disease (NXD) is characterized by arrhythmogenic right ventricular cardiomyopathy associated with abnormalities of the skin, hair, and nails. The ectodermal features are evident from birth or early childhood, whereas the cardiac symptoms develop in young adulthood or later. Clinical variability of ectodermal features has been observed, with hair anomalies ranging from woolly hair to alopecia, and skin abnormalities ranging from mild focal palmoplantar keratoderma to generalized skin fragility or even lethal neonatal epidermolysis bullosa (Protonotarios et al., 1986; Cabral et al., 2010; Pigors et al., 2011; Erken et al., 2011; Sen-Chowdhry and McKenna, 2014). Another syndrome involving cardiomyopathy, woolly hair, and keratoderma (DCWHK; 605676) is caused by mutation in the desmoplakin gene (DSP; 125647). Also see 610476 for a similar disorder caused by homozygous mutation in the DSC2 gene (125645).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/321991">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_341307"><div><strong>Graves disease, susceptibility to, 1</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>341307</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1848795</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Finding</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Graves disease (GRD) is an autoimmune disorder in which antibodies to the thyrotropin receptor (TSHR; 603372) result in constitutive activation of the receptor and increased levels of thyroid hormone. Wilkin (1990) reviewed endocrine disorders of hormone excess and hormone deficiency resulting from receptor autoimmunity. Genetic Heterogeneity of Graves Disease Susceptibility to Graves disease-1 (GRD1) has been mapped to chromosome 14q31. Other susceptibility loci for Graves disease include GRD2 (603388) on chromosome 20q13, GRDX1 (300351) on Xp11, and GRDX2 (see 300351) on Xq21.33-q22. Graves disease has also been mapped to several loci that confer susceptibility to autoimmune thyroid diseases, including Hashimoto thyroiditis (HT; 140300): AITD1 (608173) on 6p11; AITD2 (608174) on 5q31-q33; AITD3 (608175) on 8q24; AITD4 (608176) on 10q, and AITD5 (601941) on 18q21.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/341307">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_336530"><div><strong>Peeling skin syndrome 1</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>336530</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1849193</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">A group of rare autosomal recessive forms of ichthyosis with clinical characteristics of superficial, asymptomatic, spontaneous peeling of the skin and histologically by a shedding of the outer layers of the epidermis. Presents with either an acral or a generalised distribution.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/336530">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_347366"><div><strong>SchC6pf-Schulz-Passarge syndrome</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>347366</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1857069</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Schopf-Schulz-Passarge syndrome (SSPS) is an autosomal recessive disorder characterized by a constellation of multiple eyelid cysts, hypodontia, hypotrichosis, palmoplantar hyperkeratosis, and onychodystrophy (summary by Mallaiah and Dickinson, 2001).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/347366">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_357279"><div><strong>Psoriasis 1, susceptibility to</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>357279</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1867449</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Finding</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Psoriasis (psoriasis vulgaris; PV) is a chronic inflammatory dermatosis that affects approximately 2% of the population. It is characterized by red, scaly skin patches that are usually found on the scalp, elbows, and knees, and may be associated with severe arthritis. The lesions are caused by abnormal keratinocyte proliferation and infiltration of inflammatory cells into the dermis and epidermis. The usual age of onset of psoriasis is between 15 and 30 years, although it can present at any age (summary by Matthews et al., 1996). Generalized pustular psoriasis (GPP) is a life-threatening disease characterized by sudden, repeated episodes of high-grade fever, generalized rash, and disseminated pustules, with hyperleukocytosis and elevated serum levels of C-reactive protein (123260) (summary by Marrakchi et al., 2011). GPP often presents in patients with existing or prior psoriasis vulgaris; however, GPP can develop without a history of PV (Sugiura et al., 2013). Palmoplantar pustulosis and acrodermatitis continua of Hallopeau represent acral forms of pustular psoriasis that have historically been grouped with GPP (summary by Setta-Kaffetzi et al., 2013). Nestle et al. (2009) provided a detailed review of the pathogenesis and genetics of psoriasis. Genetic Heterogeneity of Psoriasis and Psoriasis Susceptibility PSORS2 (602723) is caused by mutation in the CARD14 gene (607211) on chromosome 17q25, and PSORS14 (614204) is caused by mutation in the IL36RN gene (605507) on chromosome 2q14. Psoriasis susceptibility loci include PSORS1 on 6p21.3; PSORS3 (601454) on 4q; PSORS4 on 1q21; PSORS5 (604316) on 3q21; PSORS6 (605364) on 19p; PSORS7 (605606) on 1p; PSORS8 (610707) on 16q; PSORS9 (607857) on 4q31; PSORS10 (612410) on 18p11; PSORS11 (612599) on 5q31-q33; PSORS12 (612950) on 20q13; PSORS13 (614070), conferred by variation in the TRAF3IP2 gene (607043) on 6q21; and PSORS15 (616106), conferred by variation in the AP1S3 gene (615781) on 2q36. An additional putative psoriasis candidate locus has been reported on 20p (Nair et al., 1997).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/357279">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_419717"><div><strong>Palmoplantar keratoderma i, striate, focal, or diffuse</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>419717</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C2931122</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Striate palmoplantar keratoderma belongs to a group of skin diseases in which there is thickening of the skin on the palms and soles. The striate form is characterized by longitudinal hyperkeratotic lesions extending the length of each finger to the palm, and hyperkeratotic lesions are restricted to regions of the body where pressure and abrasion are greatest (summary by Hunt et al., 2001). Patients with diffuse or focal forms of keratoderma associated with mutation in the DSG1 gene have also been reported (Keren et al., 2005; Milingou et al., 2006). Genetic Heterogeneity of Keratosis Palmoplantaris Striata Type II PPKS (PPKS2; 612908) is caused by mutation in the DSP gene (125647) on chromosome 6. Type III PPKS (PPKS3; 607654) is caused by mutation in the keratin-1 gene (KRT1; 139350) on chromosome 12q. For a general phenotypic description and a discussion of genetic heterogeneity of palmoplantar keratoderma (PPK), see epidermolytic PPK (144200). Nitoiu et al. (2014) reviewed desmosome biology in cardiocutaneous syndromes and inherited skin disease, including discussion of the involvement of the DSG1 and DSP genes.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/419717">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_482833"><div><strong>Familial cutaneous telangiectasia and oropharyngeal predisposition cancer syndrome</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>482833</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C3281203</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Neoplastic Process</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Patients with familial cutaneous telangiectasia and cancer syndrome (FCTCS) develop cutaneous telangiectases in infancy with patchy alopecia over areas of affected skin, thinning of the lateral eyebrows, and mild dental and nail anomalies. Affected individuals are at increased risk of developing oropharyngeal cancer, and other malignancies have been reported as well (Tanaka et al., 2012).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/482833">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_767031"><div><strong>Ectodermal dysplasia 7, hair/nail type</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>767031</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C3554117</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Some ectodermal dysplasias are here classified as congenital disorders characterized by abnormal development in 2 or more ectodermal structures (hair, nails, teeth, and sweat glands) without other systemic findings. Ectodermal dysplasia of the hair/nail type is a rare congenital condition characterized by hypotrichosis and nail dystrophy without nonectodermal or other ectodermal manifestations.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/767031">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_870434"><div><strong>Ectodermal dysplasia 4, hair/nail type</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>870434</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C4024880</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Some ectodermal dysplasias are here classified as congenital disorders characterized by abnormal development in 2 or more ectodermal structures (hair, nails, teeth, and sweat glands) without other systemic findings. Ectodermal dysplasia of the hair/nail type is a rare congenital condition characterized by hypotrichosis and nail dystrophy without nonectodermal or other ectodermal manifestations.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/870434">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_902464"><div><strong>Peeling skin-leukonuchia-acral punctate keratoses-cheilitis-knuckle pads syndrome</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>902464</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C4225381</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">A rare genetic skin disease characterized by generalized skin peeling, leukonychia, acral punctate keratoses coalescing into focal keratoderma on the weight-bearing areas, angular cheilitis and knuckle pads with multiple hyperkeratotic micropapules. The skin appears dry and scaly with superficial exfoliation and underlying erythema. Histopathologic examination of affected skin areas shows hyperkeratosis, acanthosis and intraepidermal clefting with irregular acantholysis. Additional systemic abnormalities are absent.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/902464">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_899946"><div><strong>Singleton-Merten syndrome 1</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>899946</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C4225427</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Singleton-Merten syndrome (SGMRT) is an uncommon autosomal dominant disorder characterized by abnormalities of blood vessels, teeth, and bone. Calcifications of the aorta and aortic and mitral valves occur in childhood or puberty and can lead to early death. Dental findings include delayed primary tooth exfoliation and permanent tooth eruption, truncated tooth root formation, early-onset periodontal disease, and severe root and alveolar bone resorption associated with dysregulated mineralization, leading to tooth loss. Osseous features consist of osteoporosis, either generalized or limited to distal extremities, distal limb osteolysis, widened medullary cavities, and easy tearing of tendons from bone. Less common features are mild facial dysmorphism (high anterior hair line, broad forehead, smooth philtrum, thin upper vermilion border), generalized muscle weakness, psoriasis, early-onset glaucoma, and recurrent infections. The disorder manifests with variable inter- and intrafamilial phenotypes (summary by Rutsch et al., 2015). Genetic Heterogeneity of Singleton-Merten Syndrome An atypical form of Singleton-Merten syndrome (SGMRT2; 616298) is caused by mutation in the DDX58 gene (609631) on chromosome 9p21.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/899946">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_1388385"><div><strong>Epidermolysis bullosa, junctional 7, with interstitial lung disease and nephrotic syndrome</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1388385</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C4518785</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Junctional epidermolysis bullosa-7 with interstitial lung disease and nephrotic syndrome (JEB7), also known as ILNEB, is an autosomal recessive multiorgan disorder that includes congenital interstitial lung disease, nephrotic syndrome, and epidermolysis bullosa. The respiratory and renal features predominate, and lung involvement accounts for the lethal course of the disease (summary by Has et al., 2012).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1388385">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_1847702"><div><strong>Arrhythmogenic cardiomyopathy with variable ectodermal abnormalities</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1847702</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C5882696</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Arrhythmogenic cardiomyopathy with variable ectodermal abnormalities (ARCME) is characterized by severe dilated cardiomyopathy resulting in death or cardiac transplantation in childhood. Ventricular tachycardia, sustained or nonsustained, has been reported. In addition, some patients exhibit ectodermal manifestations including woolly or wiry hair, dental anomalies, dry skin, and/or dystrophic nails. Cleft lip and palate and corneal abnormalities have also been observed (Robinson et al., 2020; Henry et al., 2022).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1847702">Condition Record</a></div></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1847702" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Arrhythmogenic cardiomyopathy with variable ectodermal abnormalities</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_870434" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Ectodermal dysplasia 4, hair/nail type</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_767031" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Ectodermal dysplasia 7, hair/nail type</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1388385" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Epidermolysis bullosa, junctional 7, with interstitial lung disease and nephrotic syndrome</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_482833" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Familial cutaneous telangiectasia and oropharyngeal predisposition cancer syndrome</a></div><div class="jig-moreless" data-jigconfig="class: 'moveDown', moreText: 'See full list (16)', lessText: 'Show less', nodeBefore: 0"><span id="clinMore">
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_75669" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Familial porphyria cutanea tarda</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_341307" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Graves disease, susceptibility to, 1</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_56416" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Hidrotic ectodermal dysplasia syndrome</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_321991" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Naxos disease</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_96056" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Nonsyndromic congenital nail disorder 1</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_419717" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Palmoplantar keratoderma i, striate, focal, or diffuse</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_336530" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Peeling skin syndrome 1</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_902464" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Peeling skin-leukonuchia-acral punctate keratoses-cheilitis-knuckle pads syndrome</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_357279" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Psoriasis 1, susceptibility to</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_347366" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">SchC6pf-Schulz-Passarge syndrome</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_899946" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Singleton-Merten syndrome 1</a></div></span></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_105">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Professional_guidelines">Professional guidelines</h1><a sid="105" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">PubMed<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpPM"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/35238267">Optimal diagnosis and management of common nail disorders.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Lee DK,
|
||
Lipner SR</span><br />
|
||
<span class="medgenPMjournal">Ann Med</span>
|
||
2022 Dec;54(1):694-712.
|
||
doi: 10.1080/07853890.2022.2044511.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35238267" target="_blank">35238267</a><a href="/pmc/articles/PMC8896184" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/32783318">Management of nail psoriasis with a single injection of abobotulinum toxin.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Botsali A,
|
||
Erbil H</span><br />
|
||
<span class="medgenPMjournal">J Cosmet Dermatol</span>
|
||
2021 May;20(5):1418-1420.
|
||
Epub 2020 Aug 11
|
||
doi: 10.1111/jocd.13633.
|
||
<span class="bold">PMID: </span><a href="/pubmed/32783318" target="_blank">32783318</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/27226341">Laser and light therapies for the treatment of nail psoriasis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Maranda EL,
|
||
Nguyen AH,
|
||
Lim VM,
|
||
Hafeez F,
|
||
Jimenez JJ</span><br />
|
||
<span class="medgenPMjournal">J Eur Acad Dermatol Venereol</span>
|
||
2016 Aug;30(8):1278-84.
|
||
Epub 2016 May 26
|
||
doi: 10.1111/jdv.13678.
|
||
<span class="bold">PMID: </span><a href="/pubmed/27226341" target="_blank">27226341</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(%22onycholysis%22%5Btiab%3A~0%5D)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">See all (25)</a></div></div>
|
||
</div>
|
||
<div class="display-none help-popup" id="guidelinesHelpPM">These guidelines are articles in PubMed that match specific search criteria developed by MedGen to capture the most relevant practice guidelines. This list may not be comprehensive and may include broader topics as well. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div><div class="display-none help-popup" id="guidelinesHelpCurated">These guidelines are manually curated by the MedGen team
|
||
to supplement articles available in PubMed. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div>
|
||
<div class="portlet mgSection" id="ID_103">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_clinical_studies">Recent clinical studies</h1><a sid="103" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">Etiology</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/35697407">Nail Psoriasis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Canal-García E,
|
||
Bosch-Amate X,
|
||
Belinchón I,
|
||
Puig L</span><br />
|
||
<span class="medgenPMjournal">Actas Dermosifiliogr</span>
|
||
2022 May;113(5):481-490.
|
||
Epub 2022 Feb 2
|
||
doi: 10.1016/j.ad.2022.01.006.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35697407" target="_blank">35697407</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/33745632">Nail Psoriasis in Older Adults: Epidemiology, Diagnosis, and Topical Therapy.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Ricardo JW,
|
||
Lipner SR</span><br />
|
||
<span class="medgenPMjournal">Dermatol Clin</span>
|
||
2021 Apr;39(2):183-193.
|
||
Epub 2021 Feb 11
|
||
doi: 10.1016/j.det.2020.12.011.
|
||
<span class="bold">PMID: </span><a href="/pubmed/33745632" target="_blank">33745632</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/30793352">Nail cosmetics: a dermatological perspective.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Dinani N,
|
||
George S</span><br />
|
||
<span class="medgenPMjournal">Clin Exp Dermatol</span>
|
||
2019 Aug;44(6):599-605.
|
||
Epub 2019 Feb 21
|
||
doi: 10.1111/ced.13929.
|
||
<span class="bold">PMID: </span><a href="/pubmed/30793352" target="_blank">30793352</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/29077504">Point-of-Care Diagnosis of Onychomycosis by Dermoscopy.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Bodman MA</span><br />
|
||
<span class="medgenPMjournal">J Am Podiatr Med Assoc</span>
|
||
2017 Sep;107(5):413-418.
|
||
doi: 10.7547/16-183.
|
||
<span class="bold">PMID: </span><a href="/pubmed/29077504" target="_blank">29077504</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/24079587">Common nail disorders.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Shemer A,
|
||
Daniel CR 3rd</span><br />
|
||
<span class="medgenPMjournal">Clin Dermatol</span>
|
||
2013 Sep-Oct;31(5):578-86.
|
||
doi: 10.1016/j.clindermatol.2013.06.015.
|
||
<span class="bold">PMID: </span><a href="/pubmed/24079587" target="_blank">24079587</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Onycholysis%22%20AND%20Etiology%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (134)</a></div><h3 class="subhead">Diagnosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/35697407">Nail Psoriasis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Canal-García E,
|
||
Bosch-Amate X,
|
||
Belinchón I,
|
||
Puig L</span><br />
|
||
<span class="medgenPMjournal">Actas Dermosifiliogr</span>
|
||
2022 May;113(5):481-490.
|
||
Epub 2022 Feb 2
|
||
doi: 10.1016/j.ad.2022.01.006.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35697407" target="_blank">35697407</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/35238267">Optimal diagnosis and management of common nail disorders.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Lee DK,
|
||
Lipner SR</span><br />
|
||
<span class="medgenPMjournal">Ann Med</span>
|
||
2022 Dec;54(1):694-712.
|
||
doi: 10.1080/07853890.2022.2044511.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35238267" target="_blank">35238267</a><a href="/pmc/articles/PMC8896184" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/31738146">Onychomycosis: An Updated Review.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Leung AKC,
|
||
Lam JM,
|
||
Leong KF,
|
||
Hon KL,
|
||
Barankin B,
|
||
Leung AAM,
|
||
Wong AHC</span><br />
|
||
<span class="medgenPMjournal">Recent Pat Inflamm Allergy Drug Discov</span>
|
||
2020;14(1):32-45.
|
||
doi: 10.2174/1872213X13666191026090713.
|
||
<span class="bold">PMID: </span><a href="/pubmed/31738146" target="_blank">31738146</a><a href="/pmc/articles/PMC7509699" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/30156621">Retronychia.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Mello CDBF,
|
||
Souza MDRE,
|
||
Noriega LF,
|
||
Chiacchio ND</span><br />
|
||
<span class="medgenPMjournal">An Bras Dermatol</span>
|
||
2018 Sep-Oct;93(5):707-711.
|
||
doi: 10.1590/abd1806-4841.20187908.
|
||
<span class="bold">PMID: </span><a href="/pubmed/30156621" target="_blank">30156621</a><a href="/pmc/articles/PMC6106670" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/15450905">Nail dystrophies.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Bodman MA</span><br />
|
||
<span class="medgenPMjournal">Clin Podiatr Med Surg</span>
|
||
2004 Oct;21(4):663-87, viii.
|
||
doi: 10.1016/j.cpm.2004.05.005.
|
||
<span class="bold">PMID: </span><a href="/pubmed/15450905" target="_blank">15450905</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Onycholysis%22%20AND%20Diagnosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (230)</a></div><h3 class="subhead">Therapy</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/31738146">Onychomycosis: An Updated Review.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Leung AKC,
|
||
Lam JM,
|
||
Leong KF,
|
||
Hon KL,
|
||
Barankin B,
|
||
Leung AAM,
|
||
Wong AHC</span><br />
|
||
<span class="medgenPMjournal">Recent Pat Inflamm Allergy Drug Discov</span>
|
||
2020;14(1):32-45.
|
||
doi: 10.2174/1872213X13666191026090713.
|
||
<span class="bold">PMID: </span><a href="/pubmed/31738146" target="_blank">31738146</a><a href="/pmc/articles/PMC7509699" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/29953667">Photoonycholysis: new findings.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Baran R,
|
||
Mascaro JM,
|
||
Aguilera P</span><br />
|
||
<span class="medgenPMjournal">J Eur Acad Dermatol Venereol</span>
|
||
2019 Jan;33(1):56-62.
|
||
Epub 2018 Jul 20
|
||
doi: 10.1111/jdv.15151.
|
||
<span class="bold">PMID: </span><a href="/pubmed/29953667" target="_blank">29953667</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/16798438">Drug-induced nail diseases.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Piraccini BM,
|
||
Iorizzo M,
|
||
Starace M,
|
||
Tosti A</span><br />
|
||
<span class="medgenPMjournal">Dermatol Clin</span>
|
||
2006 Jul;24(3):387-91.
|
||
doi: 10.1016/j.det.2006.03.004.
|
||
<span class="bold">PMID: </span><a href="/pubmed/16798438" target="_blank">16798438</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/12390677">Photoonycholysis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Baran R,
|
||
Juhlin L</span><br />
|
||
<span class="medgenPMjournal">Photodermatol Photoimmunol Photomed</span>
|
||
2002 Aug;18(4):202-7.
|
||
doi: 10.1034/j.1600-0781.2002.00760.x.
|
||
<span class="bold">PMID: </span><a href="/pubmed/12390677" target="_blank">12390677</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/4063194">Spontaneous photo-onycholysis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Logan RA,
|
||
Hawk JL</span><br />
|
||
<span class="medgenPMjournal">Br J Dermatol</span>
|
||
1985 Nov;113(5):605-10.
|
||
doi: 10.1111/j.1365-2133.1985.tb02386.x.
|
||
<span class="bold">PMID: </span><a href="/pubmed/4063194" target="_blank">4063194</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Onycholysis%22%20AND%20Therapy%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (271)</a></div><h3 class="subhead">Prognosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/33336579">Nail Changes in Lichen Planus: A Single-Center Study.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Żychowska M,
|
||
Żychowska M</span><br />
|
||
<span class="medgenPMjournal">J Cutan Med Surg</span>
|
||
2021 May-Jun;25(3):281-285.
|
||
Epub 2020 Dec 18
|
||
doi: 10.1177/1203475420982554.
|
||
<span class="bold">PMID: </span><a href="/pubmed/33336579" target="_blank">33336579</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/29077504">Point-of-Care Diagnosis of Onychomycosis by Dermoscopy.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Bodman MA</span><br />
|
||
<span class="medgenPMjournal">J Am Podiatr Med Assoc</span>
|
||
2017 Sep;107(5):413-418.
|
||
doi: 10.7547/16-183.
|
||
<span class="bold">PMID: </span><a href="/pubmed/29077504" target="_blank">29077504</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/12823307">Prediction of outcome in the treatment of onychomycosis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Sommer S,
|
||
Sheehan-Dare RA,
|
||
Goodfield MJ,
|
||
Evans EG</span><br />
|
||
<span class="medgenPMjournal">Clin Exp Dermatol</span>
|
||
2003 Jul;28(4):425-8.
|
||
doi: 10.1046/j.1365-2230.2003.01308.x.
|
||
<span class="bold">PMID: </span><a href="/pubmed/12823307" target="_blank">12823307</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/12423438">Docetaxel-induced nail dystrophy.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Nicolopoulos J,
|
||
Howard A</span><br />
|
||
<span class="medgenPMjournal">Australas J Dermatol</span>
|
||
2002 Nov;43(4):293-6.
|
||
doi: 10.1046/j.1440-0960.2002.00616.x.
|
||
<span class="bold">PMID: </span><a href="/pubmed/12423438" target="_blank">12423438</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/11193280">Critical illness onychomadesis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Wester JP,
|
||
van Eps RS,
|
||
Stouthamer A,
|
||
Girbes AR</span><br />
|
||
<span class="medgenPMjournal">Intensive Care Med</span>
|
||
2000 Nov;26(11):1698-700.
|
||
doi: 10.1007/s001340000679.
|
||
<span class="bold">PMID: </span><a href="/pubmed/11193280" target="_blank">11193280</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Onycholysis%22%20AND%20Prognosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (79)</a></div><h3 class="subhead">Clinical prediction guides</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/31738146">Onychomycosis: An Updated Review.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Leung AKC,
|
||
Lam JM,
|
||
Leong KF,
|
||
Hon KL,
|
||
Barankin B,
|
||
Leung AAM,
|
||
Wong AHC</span><br />
|
||
<span class="medgenPMjournal">Recent Pat Inflamm Allergy Drug Discov</span>
|
||
2020;14(1):32-45.
|
||
doi: 10.2174/1872213X13666191026090713.
|
||
<span class="bold">PMID: </span><a href="/pubmed/31738146" target="_blank">31738146</a><a href="/pmc/articles/PMC7509699" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/30374901">Toxic Side Effects of Targeted Therapies and Immunotherapies Affecting the Skin, Oral Mucosa, Hair, and Nails.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Lacouture M,
|
||
Sibaud V</span><br />
|
||
<span class="medgenPMjournal">Am J Clin Dermatol</span>
|
||
2018 Nov;19(Suppl 1):31-39.
|
||
doi: 10.1007/s40257-018-0384-3.
|
||
<span class="bold">PMID: </span><a href="/pubmed/30374901" target="_blank">30374901</a><a href="/pmc/articles/PMC6244569" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/27824223">Onychomycosis by Paecilomyces lilacinus.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Pontini P,
|
||
Gorani A,
|
||
Veraldi S</span><br />
|
||
<span class="medgenPMjournal">G Ital Dermatol Venereol</span>
|
||
2016 Dec;151(6):706-709.
|
||
<span class="bold">PMID: </span><a href="/pubmed/27824223" target="_blank">27824223</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/12477371">Drug-induced nail abnormalities.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Piraccini BM,
|
||
Iorizzo M,
|
||
Tosti A</span><br />
|
||
<span class="medgenPMjournal">Am J Clin Dermatol</span>
|
||
2003;4(1):31-7.
|
||
doi: 10.2165/00128071-200304010-00004.
|
||
<span class="bold">PMID: </span><a href="/pubmed/12477371" target="_blank">12477371</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/12390677">Photoonycholysis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Baran R,
|
||
Juhlin L</span><br />
|
||
<span class="medgenPMjournal">Photodermatol Photoimmunol Photomed</span>
|
||
2002 Aug;18(4):202-7.
|
||
doi: 10.1034/j.1600-0781.2002.00760.x.
|
||
<span class="bold">PMID: </span><a href="/pubmed/12390677" target="_blank">12390677</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Onycholysis%22%20AND%20Clinical%20prediction%20guides%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (124)</a></div></div>
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_systematic_reviews">Recent systematic reviews</h1><a sid="104" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="nl"><a target="_blank" href="/pubmed/38520074">Dermoscopic features of nail psoriasis: a systematic review.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Rachadi H,
|
||
Chiheb S</span><br />
|
||
<span class="medgenPMjournal">Int J Dermatol</span>
|
||
2024 Aug;63(8):1013-1019.
|
||
Epub 2024 Mar 22
|
||
doi: 10.1111/ijd.17138.
|
||
<span class="bold">PMID: </span><a href="/pubmed/38520074" target="_blank">38520074</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/35078455">The influence of docetaxel schedule on treatment tolerability and efficacy in patients with metastatic breast cancer: a systematic review and meta-analysis of randomized controlled trials.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">van Eijk M,
|
||
Vermunt MAC,
|
||
van Werkhoven E,
|
||
Wilthagen EA,
|
||
Huitema ADR,
|
||
Beijnen JH</span><br />
|
||
<span class="medgenPMjournal">BMC Cancer</span>
|
||
2022 Jan 25;22(1):104.
|
||
doi: 10.1186/s12885-022-09196-x.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35078455" target="_blank">35078455</a><a href="/pmc/articles/PMC8788086" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/31184794">Prophylactic management for taxane-induced nail toxicity: A systematic review and meta-analysis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Huang KL,
|
||
Lin KY,
|
||
Huang TW,
|
||
Loh EW,
|
||
Hua YM,
|
||
Su HC,
|
||
Tam KW</span><br />
|
||
<span class="medgenPMjournal">Eur J Cancer Care (Engl)</span>
|
||
2019 Sep;28(5):e13118.
|
||
Epub 2019 Jun 11
|
||
doi: 10.1111/ecc.13118.
|
||
<span class="bold">PMID: </span><a href="/pubmed/31184794" target="_blank">31184794</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/30422349">Dermoscopic features of psoriasis of the skin, scalp and nails - a systematic review.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Golińska J,
|
||
Sar-Pomian M,
|
||
Rudnicka L</span><br />
|
||
<span class="medgenPMjournal">J Eur Acad Dermatol Venereol</span>
|
||
2019 Apr;33(4):648-660.
|
||
doi: 10.1111/jdv.15344.
|
||
<span class="bold">PMID: </span><a href="/pubmed/30422349" target="_blank">30422349</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/30383138">Evaluation of Prevention Interventions for Taxane-Induced Dermatologic Adverse Events: A Systematic Review.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Marks DH,
|
||
Qureshi A,
|
||
Friedman A</span><br />
|
||
<span class="medgenPMjournal">JAMA Dermatol</span>
|
||
2018 Dec 1;154(12):1465-1472.
|
||
doi: 10.1001/jamadermatol.2018.3465.
|
||
<span class="bold">PMID: </span><a href="/pubmed/30383138" target="_blank">30383138</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Onycholysis%22%20AND%20systematic%5Bsb%5D%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (7)</a></div></div>
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<h2 class="offscreen_noflow">Supplemental Content</h2>
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<div class="portlet_content ln"><ul class="a_poppers"><li><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(%22onycholysis%22%5Btiab%3A~0%5D)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">PubMed</a><div class="help-popup">See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div></li><li><a target="_blank" href="/books/?term=((%22clinical%20guidelines%22%5BResource%20Type%5D)%20OR%20%22practice%20guideline%22%5BPublication%20Type%5D)%20AND%20(%22Onycholysis%22)">Bookshelf</a><div class="help-popup">See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div></li></ul></div>
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