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<meta name="keywords" content="C1846868, disease or syndrome, favorable response to levodopa, favourable response to levodopa, finding, parkinsonism with favorable response to dopaminergic medication, parkinsonism with favourable response to dopaminergic medication, autosomal dominant, autosomal recessive, birth defects, chromosomal disease, chromosome, clinical features, clinical findings, clinical genetics, clinical recommendations, clinvar, congenital chromosomal disease, consumer genetic resources, cytogenetic location, disease characteristics, disease definitions, disease descriptions, disease ontology, disease synonyms, disease vocabulary, dysmorphology, entrez, familial disease, gene, gene-disease relationship, genereviews, genetic disease, genetic disorder, genetic terminology, genetic testing registry, genetics home reference, genomic disease, gtr, hereditary disease, heritable disease, hpo, human phenotype ontology, inherited disease, management guidelines, maternal inheritance, medgen, medical genetics, medical subject headings, mesh, mitochondrial inheritance, mode of inheritance, national center for biotechnology information, national institutes of health, national library of medicine, ncbi, nih, nlm, omim, ordo, orphanet, paternal inheritance, phenome, position statements, professional practice guidelines, rare disease, reference sequence, refseq, snomed ct, syndrome, undiagnosed diseases, x-linked recessive" /><meta name="description" content="Parkinsonism is a clinical syndrome that is a feature of a number of different diseases, including Parkinson disease itself, other neurodegenerative diseases such as progressive supranuclear palsy, and as a side-effect of some neuroleptic medications. Some but not all individuals with Parkinsonism show responsiveness to dopaminergic medication defined as a substantial reduction of amelioration of the component signs of Parkinsonism (including mainly tremor, bradykinesia, rigidity, and postural instability) upon administration of dopaminergic medication." /><meta name="robots" content="index,nofollow,noarchive" />
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<!--
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UID=375989
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ConceptID=C1846868
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<!--imgCountBooks = 0--><h1 class="medgenTitle"><div class="MedGenTitleText">Parkinsonism with favorable response to dopaminergic medication</div></h1><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>375989</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1846868</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome; Finding</dd></dl></div></div><table class="medgenTable"><tbody><tr><td>Synonyms:</td>
|
||
<td>Favorable response to levodopa; Favourable response to levodopa; Parkinsonism with favourable response to dopaminergic medication</td></tr>
|
||
<tr><td colspan="2" class="small"> </td></tr><tr><td>HPO:</td>
|
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<td><a target="_blank" title="Human Phenotype Ontology" href="https://hpo.jax.org/app/browse/term/HP:0002548">HP:0002548</a></td></tr>
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Definition">Definition</h1><a sid="100" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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||
<div class="portlet_content ln">Parkinsonism is a clinical syndrome that is a feature of a number of different diseases, including Parkinson disease itself, other neurodegenerative diseases such as progressive supranuclear palsy, and as a side-effect of some neuroleptic medications. Some but not all individuals with Parkinsonism show responsiveness to dopaminergic medication defined as a substantial reduction of amelioration of the component signs of Parkinsonism (including mainly tremor, bradykinesia, rigidity, and postural instability) upon administration of dopaminergic medication. [from <a title="Human Phenotype Ontology" href="http://www.human-phenotype-ontology.org" class="defSource" target="_blank">HPO</a>]</div>
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Term_Hierarchy">Term Hierarchy</h1><a sid="118" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
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<div class="portlet_content ln HierarchyGTR"><div class="jig-ncbitabs"><ul><li><a href="#tabGTR">GTR</a></li><li><a href="#tabMGEN">MeSH</a></li></ul><div id="tabGTR"><div class="search_result"><div class="rprts"><div class="chiclet_legend"><span class="chiclet_list" style="position:static;"><span title="Clinical test" class="chiclet Ccolor round">C</span><span>Clinical test, </span><span title="Research test" class="chiclet Rcolor round">R</span><span>Research test, </span><span title="OMIM" class="chiclet Ocolor ">O</span><span>OMIM, </span><span title="GeneReview" class="chiclet Gcolor">G</span><span><em>GeneReviews</em>, </span><span title="ClinVar" class="chiclet Vcolor">V</span><span>ClinVar </span></span></div><div id="hierarchy" class="margin_t1"><div class="ds_tree"><ul><li class="matched_ds"><span class="chiclet_list"><span class="chiclet unavailable round" title="Clinical test">C</span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet unavailable" title="OMIM">O</span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet unavailable" title="ClinVar">V</span></span><span class="TLline">Parkinsonism with favorable response to dopaminergic medication</span></li></ul></div></div></div></div></div><div id="tabMGEN"><div class="ds_tree"><ul><li><span class="TLline"><a href="/medgen/474891" ref="tree=MeSH" title="MedGen record for Congenital Systemic Disorder">Congenital Systemic Disorder</a></span><ul><li><span class="TLline"><a href="/medgen/105425" ref="tree=MeSH" title="MedGen record for Abnormality of the nervous system">Abnormality of the nervous system</a></span><ul><li><span class="TLline"><a href="/medgen/868417" ref="tree=MeSH" title="MedGen record for Abnormal nervous system physiology">Abnormal nervous system physiology</a></span><ul><li><span class="TLline"><a href="/medgen/868940" ref="tree=MeSH" title="MedGen record for Abnormal central motor function">Abnormal central motor function</a></span><ul><li><span class="TLline"><a href="/medgen/115941" ref="tree=MeSH" title="MedGen record for Abnormality of extrapyramidal motor function">Abnormality of extrapyramidal motor function</a></span><ul><li><span class="TLline"><a href="/medgen/66079" ref="tree=MeSH" title="MedGen record for Parkinsonian disorder">Parkinsonian disorder</a></span><ul><li><span class="matched_ds">Parkinsonism with favorable response to dopaminergic medication</span></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></div></div></div></div>
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||
</div>
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||
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<div class="portlet mgSection" id="ID_112">
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||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Conditions_with_this_feature">Conditions with this feature</h1><a sid="112" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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||
<div class="portlet_content ln clinfeat">
|
||
<div class="divPopper rprt" id="rdis_42426"><div><strong>Wilson disease</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>42426</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0019202</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Wilson disease is a disorder of copper metabolism that, when untreated, can present with hepatic, neurologic, or psychiatric disturbances – or a combination of these – in individuals ages three years to older than 70 years. Manifestations in untreated individuals vary among and within families. Liver disease can include recurrent jaundice, simple acute self-limited hepatitis-like illness, autoimmune-type hepatitis, fulminant hepatic failure, or chronic liver disease. Neurologic presentations can include dysarthria, movement disorders (tremors, involuntary movements, chorea, choreoathetosis), dystonia (mask-like facies, rigidity, gait disturbance, pseudobulbar involvement), dysautonomia, seizures, sleep disorders, or insomnia. Psychiatric disturbances can include depression, bipolar disorder / bipolar spectrum disorder, neurotic behaviors, personality changes, or psychosis. Other multisystem involvement can include the eye (Kayser-Fleischer rings), hemolytic anemia, the kidneys, the endocrine glands, and the heart.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/42426">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_208674"><div><strong>Early-onset parkinsonism-intellectual disability syndrome</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>208674</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0796195</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Waisman syndrome (WSMN) is an X-linked neurologic disorder characterized by delayed psychomotor development, impaired intellectual development, and early-onset Parkinson disease (summary by Wilson et al., 2014).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/208674">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_371919"><div><strong>Progressive external ophthalmoplegia with mitochondrial DNA deletions, autosomal dominant 1</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>371919</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1834846</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">POLG-related disorders comprise a continuum of overlapping phenotypes that were clinically defined before the molecular basis was known. POLG-related disorders can therefore be considered an overlapping spectrum of disease presenting from early childhood to late adulthood. The age of onset broadly correlates with the clinical phenotype. In individuals with early-onset disease (prior to age 12 years), liver involvement, feeding difficulties, seizures, hypotonia, and muscle weakness are the most common clinical features. This group has the worst prognosis. In the juvenile/adult-onset form (age 12-40 years), disease is typically characterized by peripheral neuropathy, ataxia, seizures, stroke-like episodes, and, in individuals with longer survival, progressive external ophthalmoplegia (PEO). This group generally has a better prognosis than the early-onset group. Late-onset disease (after age 40 years) is characterized by ptosis and PEO, with additional features such as peripheral neuropathy, ataxia, and muscle weakness. This group overall has the best prognosis.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/371919">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_326820"><div><strong>X-linked dystonia-parkinsonism</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>326820</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1839130</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Individuals with X-linked dystonia-parkinsonism (XDP) have dystonia of varying severity and parkinsonism. XDP afflicts primarily Filipino men and, rarely, women. The mean age of onset in men is 39 years; the clinical course is highly variable with parkinsonism as the initial presenting sign, overshadowed by dystonia as the disease progresses. Features of parkinsonism include resting tremor, bradykinesia, rigidity, postural instability, and severe shuffling gait. The dystonia develops focally, most commonly in the jaw, neck, trunk, and eyes, and less commonly in the limbs, tongue, pharynx, and larynx, the most characteristic being jaw dystonia often progressing to neck dystonia. Individuals with pure parkinsonism have non-disabling symptoms that are only slowly progressive; those who develop a combination of parkinsonism and dystonia can develop multifocal or generalized symptoms within a few years and die prematurely from pneumonia or intercurrent infections. Female carriers are mostly asymptomatic, though a small minority may manifest dystonia, parkinsonism, or chorea.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/326820">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_339628"><div><strong>Autosomal dominant Parkinson disease 8</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>339628</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1846862</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">LRRK2 Parkinson disease (PD) is characterized by features consistent with idiopathic PD: initial motor features of slowly progressive asymmetric tremor at rest and/or bradykinesia, cogwheel muscle rigidity, postural instability, and gait abnormalities that may include festination and freezing. Certain nonmotor symptoms in LRRK2-PD, especially REM sleep behavior disorder and cognitive decline, may occur at similar or slightly reduced frequency compared to typical idiopathic* PD. Onset is generally after age 50, although early-onset (in the 20s) and late-onset (in the 90s) disease has been described. * Idiopathic PD refers to the presence of signs and symptoms of PD for which the etiology is currently unknown and in which there is no known family history of PD.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/339628">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_338281"><div><strong>Kufor-Rakeb syndrome</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>338281</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1847640</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Kufor-Rakeb syndrome is a rare autosomal recessive form of juvenile-onset atypical Parkinson disease (PARK9) associated with supranuclear gaze palsy, spasticity, and dementia. Some patients have neuroradiologic evidence of iron deposition in the basal ganglia, indicating that the pathogenesis of PARK9 can be considered among the syndromes of neurodegeneration with brain iron accumulation (NBIA; see 234200) (summary by Bruggemann et al., 2010). For a phenotypic description and a discussion of genetic heterogeneity of Parkinson disease (PD), see 168600. Biallelic mutation in the ATP13A2 gene also causes autosomal recessive spastic paraplegia-78 (SPG78; 617225), an adult-onset neurodegenerative disorder with overlapping features. Patients with SPG78 have later onset and prominent spasticity, but rarely parkinsonism. Loss of ATP13A2 function results in a multidimensional spectrum of neurologic features reflecting various regions of the brain and nervous system, including cortical, pyramidal, extrapyramidal, brainstem, cerebellar, and peripheral (summary by Estrada-Cuzcano et al., 2017).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/338281">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_337969"><div><strong>Parkinsonian-pyramidal syndrome</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>337969</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1850100</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Parkinson's disease is a progressive disorder of the nervous system. The disorder affects several regions of the brain, especially an area called the substantia nigra that controls balance and movement.\n\nGenerally, Parkinson's disease that begins after age 50 is called late-onset disease. The condition is described as early-onset disease if signs and symptoms begin before age 50. Early-onset cases that begin before age 20 are sometimes referred to as juvenile-onset Parkinson's disease.\n\nOften the first symptom of Parkinson's disease is trembling or shaking (tremor) of a limb, especially when the body is at rest. Typically, the tremor begins on one side of the body, usually in one hand. Tremors can also affect the arms, legs, feet, and face. Other characteristic symptoms of Parkinson's disease include rigidity or stiffness of the limbs and torso, slow movement (bradykinesia) or an inability to move (akinesia), and impaired balance and coordination (postural instability). These symptoms worsen slowly over time.\n\nParkinson's disease can also affect emotions and thinking ability (cognition). Some affected individuals develop psychiatric conditions such as depression and visual hallucinations. People with Parkinson's disease also have an increased risk of developing dementia, which is a decline in intellectual functions including judgment and memory.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/337969">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_342121"><div><strong>Dystonia 5</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>342121</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1851920</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">GTP cyclohydrolase 1-deficient dopa-responsive dystonia (GTPCH1-deficient DRD) is characterized by childhood-onset dystonia and a dramatic and sustained response to low doses of oral administration of levodopa. This disorder typically presents with gait disturbance caused by foot dystonia, later development of parkinsonism, and diurnal fluctuation of symptoms (aggravation of symptoms toward the evening and alleviation of symptoms in the morning after sleep). Initial symptoms are often gait difficulties attributable to flexion-inversion (equinovarus posture) of the foot. Occasionally, initial symptoms are arm dystonia, postural tremor of the hand, or slowness of movements. Brisk deep-tendon reflexes in the legs, ankle clonus, and/or the striatal toe (dystonic extension of the big toe) are present in many affected individuals. In general, gradual progression to generalized dystonia is observed. Intellectual, cerebellar, sensory, and autonomic disturbances generally do not occur.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/342121">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_343992"><div><strong>Parkinson disease 13, autosomal dominant, susceptibility to</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>343992</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1853202</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Finding</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Parkinson's disease can also affect emotions and thinking ability (cognition). Some affected individuals develop psychiatric conditions such as depression and visual hallucinations. People with Parkinson's disease also have an increased risk of developing dementia, which is a decline in intellectual functions including judgment and memory.\n\nOften the first symptom of Parkinson's disease is trembling or shaking (tremor) of a limb, especially when the body is at rest. Typically, the tremor begins on one side of the body, usually in one hand. Tremors can also affect the arms, legs, feet, and face. Other characteristic symptoms of Parkinson's disease include rigidity or stiffness of the limbs and torso, slow movement (bradykinesia) or an inability to move (akinesia), and impaired balance and coordination (postural instability). These symptoms worsen slowly over time.\n\nGenerally, Parkinson's disease that begins after age 50 is called late-onset disease. The condition is described as early-onset disease if signs and symptoms begin before age 50. Early-onset cases that begin before age 20 are sometimes referred to as juvenile-onset Parkinson's disease.\n\nParkinson's disease is a progressive disorder of the nervous system. The disorder affects several regions of the brain, especially an area called the substantia nigra that controls balance and movement.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/343992">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_344049"><div><strong>Autosomal recessive early-onset Parkinson disease 7</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>344049</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1853445</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Parkinson's disease is a progressive disorder of the nervous system. The disorder affects several regions of the brain, especially an area called the substantia nigra that controls balance and movement.\n\nGenerally, Parkinson's disease that begins after age 50 is called late-onset disease. The condition is described as early-onset disease if signs and symptoms begin before age 50. Early-onset cases that begin before age 20 are sometimes referred to as juvenile-onset Parkinson's disease.\n\nOften the first symptom of Parkinson's disease is trembling or shaking (tremor) of a limb, especially when the body is at rest. Typically, the tremor begins on one side of the body, usually in one hand. Tremors can also affect the arms, legs, feet, and face. Other characteristic symptoms of Parkinson's disease include rigidity or stiffness of the limbs and torso, slow movement (bradykinesia) or an inability to move (akinesia), and impaired balance and coordination (postural instability). These symptoms worsen slowly over time.\n\nParkinson's disease can also affect emotions and thinking ability (cognition). Some affected individuals develop psychiatric conditions such as depression and visual hallucinations. People with Parkinson's disease also have an increased risk of developing dementia, which is a decline in intellectual functions including judgment and memory.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/344049">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_382128"><div><strong>Autosomal recessive DOPA responsive dystonia</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>382128</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C2673535</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Tyrosine hydroxylase (TH) deficiency is associated with a broad phenotypic spectrum. Based on severity of symptoms/signs as well as responsiveness to levodopa therapy, clinical phenotypes caused by pathogenic variants in TH are divided into (1) TH-deficient dopa-responsive dystonia (the mild form of TH deficiency), (2) TH-deficient infantile parkinsonism with motor delay (the severe form), and (3) TH-deficient progressive infantile encephalopathy (the very severe form). In individuals with TH-deficient dopa-responsive dystonia (DYT5b, DYT-TH), onset is between age 12 months and 12 years; initial symptoms are typically lower-limb dystonia and/or difficulty in walking. Diurnal fluctuation of symptoms (worsening of the symptoms toward the evening and their alleviation in the morning after sleep) may be present. In most individuals with TH-deficient infantile parkinsonism with motor delay, onset is between age three and 12 months. In contrast to TH-deficient DRD, motor milestones are overtly delayed in this severe form. Affected infants demonstrate truncal hypotonia and parkinsonian symptoms and signs (hypokinesia, rigidity of extremities, and/or tremor). In individuals with TH-deficient progressive infantile encephalopathy, onset is before age three to six months. Fetal distress is reported in most. Affected individuals have marked delay in motor development, truncal hypotonia, severe hypokinesia, limb hypertonia (rigidity and/or spasticity), hyperreflexia, oculogyric crises, ptosis, intellectual disability, and paroxysmal periods of lethargy (with increased sweating and drooling) alternating with irritability.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/382128">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_462249"><div><strong>Parkinson disease 5, autosomal dominant, susceptibility to</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>462249</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C3150899</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Finding</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Parkinson's disease is a progressive disorder of the nervous system. The disorder affects several regions of the brain, especially an area called the substantia nigra that controls balance and movement.\n\nGenerally, Parkinson's disease that begins after age 50 is called late-onset disease. The condition is described as early-onset disease if signs and symptoms begin before age 50. Early-onset cases that begin before age 20 are sometimes referred to as juvenile-onset Parkinson's disease.\n\nOften the first symptom of Parkinson's disease is trembling or shaking (tremor) of a limb, especially when the body is at rest. Typically, the tremor begins on one side of the body, usually in one hand. Tremors can also affect the arms, legs, feet, and face. Other characteristic symptoms of Parkinson's disease include rigidity or stiffness of the limbs and torso, slow movement (bradykinesia) or an inability to move (akinesia), and impaired balance and coordination (postural instability). These symptoms worsen slowly over time.\n\nParkinson's disease can also affect emotions and thinking ability (cognition). Some affected individuals develop psychiatric conditions such as depression and visual hallucinations. People with Parkinson's disease also have an increased risk of developing dementia, which is a decline in intellectual functions including judgment and memory.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/462249">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_896658"><div><strong>Parkinson disease 11, autosomal dominant, susceptibility to</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>896658</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C4083045</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Finding</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Parkinson's disease is a progressive disorder of the nervous system. The disorder affects several regions of the brain, especially an area called the substantia nigra that controls balance and movement.\n\nGenerally, Parkinson's disease that begins after age 50 is called late-onset disease. The condition is described as early-onset disease if signs and symptoms begin before age 50. Early-onset cases that begin before age 20 are sometimes referred to as juvenile-onset Parkinson's disease.\n\nOften the first symptom of Parkinson's disease is trembling or shaking (tremor) of a limb, especially when the body is at rest. Typically, the tremor begins on one side of the body, usually in one hand. Tremors can also affect the arms, legs, feet, and face. Other characteristic symptoms of Parkinson's disease include rigidity or stiffness of the limbs and torso, slow movement (bradykinesia) or an inability to move (akinesia), and impaired balance and coordination (postural instability). These symptoms worsen slowly over time.\n\nParkinson's disease can also affect emotions and thinking ability (cognition). Some affected individuals develop psychiatric conditions such as depression and visual hallucinations. People with Parkinson's disease also have an increased risk of developing dementia, which is a decline in intellectual functions including judgment and memory.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/896658">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_896607"><div><strong>Autosomal recessive early-onset Parkinson disease 23</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>896607</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C4225186</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Parkinson disease-23 (PARK23) is a progressive neurodegenerative disorder characterized by young-adult onset of parkinsonism associated with progressive cognitive impairment leading to dementia and dysautonomia. Some individuals have additional motor abnormalities. Affected individuals become severely disabled within a few decades (summary by Lesage et al., 2016).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/896607">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_907886"><div><strong>Parkinson disease 22, autosomal dominant</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>907886</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C4225238</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Any Parkinson disease in which the cause of the disease is a mutation in the CHCHD2 gene.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/907886">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_1783451"><div><strong>Parkinsonism with polyneuropathy</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1783451</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C5543299</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Parkinsonism with polyneuropathy (PKNPY) is an autosomal dominant disorder characterized by asymmetrical tremor-dependent parkinsonism. The age of onset ranges from the late forties to mid-sixties, and patients have a good response to levodopa (summary by Lin et al., 2020).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1783451">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_1794179"><div><strong>Parkinson disease 24, autosomal dominant, susceptibility to</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1794179</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C5561969</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Finding</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Parkinson disease-24 (PARK24) is an autosomal dominant disorder characterized by classic Parkinson disease features, including adult onset, asymmetric limb involvement initially, and slowly progressive motor dysfunction. PARK24 shows incomplete penetrance, consistent with the presence of the PSAP mutation being a susceptibility factor for development of the disease (Oji et al., 2020). For a phenotypic description and a discussion of genetic heterogeneity of Parkinson disease, see 168600.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1794179">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_1845571"><div><strong>Parkinson disease 25, autosomal recessive early-onset, with impaired intellectual development</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1845571</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C5882680</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Parkinson disease-25 (PARK25) is a progressive neurodegenerative disorder characterized by onset of parkinsonism in late childhood/adolescence and developmental delay/impaired intellectual development. Cognitive impairment is mild to moderate and nonprogressive (Fevga et al., 2023). For a general phenotypic description and a discussion of genetic heterogeneity of Parkinson disease, see 168600.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1845571">Condition Record</a></div></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_339628" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Autosomal dominant Parkinson disease 8</a></div>
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<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_382128" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Autosomal recessive DOPA responsive dystonia</a></div>
|
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<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_896607" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Autosomal recessive early-onset Parkinson disease 23</a></div>
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||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_344049" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Autosomal recessive early-onset Parkinson disease 7</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_342121" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Dystonia 5</a></div><div class="jig-moreless" data-jigconfig="class: 'moveDown', moreText: 'See full list (18)', lessText: 'Show less', nodeBefore: 0"><span id="clinMore">
|
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<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_208674" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Early-onset parkinsonism-intellectual disability syndrome</a></div>
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||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_338281" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Kufor-Rakeb syndrome</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_896658" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Parkinson disease 11, autosomal dominant, susceptibility to</a></div>
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||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_343992" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Parkinson disease 13, autosomal dominant, susceptibility to</a></div>
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<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_907886" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Parkinson disease 22, autosomal dominant</a></div>
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<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1794179" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Parkinson disease 24, autosomal dominant, susceptibility to</a></div>
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<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1845571" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Parkinson disease 25, autosomal recessive early-onset, with impaired intellectual development</a></div>
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||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_462249" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Parkinson disease 5, autosomal dominant, susceptibility to</a></div>
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<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_337969" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Parkinsonian-pyramidal syndrome</a></div>
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<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1783451" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Parkinsonism with polyneuropathy</a></div>
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||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_371919" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Progressive external ophthalmoplegia with mitochondrial DNA deletions, autosomal dominant 1</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_42426" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Wilson disease</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_326820" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">X-linked dystonia-parkinsonism</a></div></span></div></div>
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</div>
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<div class="portlet mgSection" id="ID_105">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Professional_guidelines">Professional guidelines</h1><a sid="105" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">PubMed<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpPM"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/39905399">Astaxanthin-loaded brain-permeable liposomes for Parkinson's disease treatment via antioxidant and anti-inflammatory responses.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Nguyen TD,
|
||
Khanal S,
|
||
Lee E,
|
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Choi J,
|
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Bohara G,
|
||
Rimal N,
|
||
Choi DY,
|
||
Park S</span><br />
|
||
<span class="medgenPMjournal">J Nanobiotechnology</span>
|
||
2025 Feb 4;23(1):78.
|
||
doi: 10.1186/s12951-025-03104-8.
|
||
<span class="bold">PMID: </span><a href="/pubmed/39905399" target="_blank">39905399</a><a href="/pmc/articles/PMC11792324" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/29458074">Subthalamic nucleus stimulation, dopaminergic treatment and impulsivity in Parkinson's disease.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Fluchère F,
|
||
Burle B,
|
||
Vidal F,
|
||
van den Wildenberg W,
|
||
Witjas T,
|
||
Eusebio A,
|
||
Azulay JP,
|
||
Hasbroucq T</span><br />
|
||
<span class="medgenPMjournal">Neuropsychologia</span>
|
||
2018 Aug;117:167-177.
|
||
Epub 2018 Feb 16
|
||
doi: 10.1016/j.neuropsychologia.2018.02.016.
|
||
<span class="bold">PMID: </span><a href="/pubmed/29458074" target="_blank">29458074</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/11346021">Catechol-O-methyltransferase inhibitors in the management of Parkinson's disease.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Hanson MR,
|
||
Gálvez-Jiménez N</span><br />
|
||
<span class="medgenPMjournal">Semin Neurol</span>
|
||
2001;21(1):15-22.
|
||
doi: 10.1055/s-2001-13115.
|
||
<span class="bold">PMID: </span><a href="/pubmed/11346021" target="_blank">11346021</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(parkinsonism%20with%20favorable%20response%20to%20dopaminergic%20medication)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">See all (4)</a></div></div>
|
||
</div>
|
||
<div class="display-none help-popup" id="guidelinesHelpPM">These guidelines are articles in PubMed that match specific search criteria developed by MedGen to capture the most relevant practice guidelines. This list may not be comprehensive and may include broader topics as well. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div><div class="display-none help-popup" id="guidelinesHelpCurated">These guidelines are manually curated by the MedGen team
|
||
to supplement articles available in PubMed. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div>
|
||
<div class="portlet mgSection" id="ID_103">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_clinical_studies">Recent clinical studies</h1><a sid="103" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">Etiology</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/38967882">Radiosurgical thalamotomy for the management of tremors: a systematic review and meta-analysis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Larcipretti ALL,
|
||
Gomes FC,
|
||
Udoma-Udofa OC,
|
||
Jannotti JBN,
|
||
Bannach MA</span><br />
|
||
<span class="medgenPMjournal">Neurol Sci</span>
|
||
2025 Jan;46(1):79-88.
|
||
Epub 2024 Jul 5
|
||
doi: 10.1007/s10072-024-07670-x.
|
||
<span class="bold">PMID: </span><a href="/pubmed/38967882" target="_blank">38967882</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/38070039">The Effects of Safinamide in Chinese and Non-Chinese Patients with Parkinson's Disease.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Cattaneo C,
|
||
Kulisevsky J</span><br />
|
||
<span class="medgenPMjournal">Adv Ther</span>
|
||
2024 Feb;41(2):638-648.
|
||
Epub 2023 Dec 9
|
||
doi: 10.1007/s12325-023-02736-2.
|
||
<span class="bold">PMID: </span><a href="/pubmed/38070039" target="_blank">38070039</a><a href="/pmc/articles/PMC10838837" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/36402160">Safety and efficacy of continuous subcutaneous foslevodopa-foscarbidopa in patients with advanced Parkinson's disease: a randomised, double-blind, active-controlled, phase 3 trial.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Soileau MJ,
|
||
Aldred J,
|
||
Budur K,
|
||
Fisseha N,
|
||
Fung VS,
|
||
Jeong A,
|
||
Kimber TE,
|
||
Klos K,
|
||
Litvan I,
|
||
O'Neill D,
|
||
Robieson WZ,
|
||
Spindler MA,
|
||
Standaert DG,
|
||
Talapala S,
|
||
Vaou EO,
|
||
Zheng H,
|
||
Facheris MF,
|
||
Hauser RA</span><br />
|
||
<span class="medgenPMjournal">Lancet Neurol</span>
|
||
2022 Dec;21(12):1099-1109.
|
||
doi: 10.1016/S1474-4422(22)00400-8.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36402160" target="_blank">36402160</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/32568108">Carbidopa and Levodopa Extended Release Capsules in Patients with and without Troublesome and Non-Troublesome Dyskinesia.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Hauser RA,
|
||
Zeitlin L,
|
||
Fisher S,
|
||
D'Souza R</span><br />
|
||
<span class="medgenPMjournal">J Parkinsons Dis</span>
|
||
2020;10(3):915-925.
|
||
doi: 10.3233/JPD-202010.
|
||
<span class="bold">PMID: </span><a href="/pubmed/32568108" target="_blank">32568108</a><a href="/pmc/articles/PMC7458518" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/28668671">Deutetrabenazine for treatment of involuntary movements in patients with tardive dyskinesia (AIM-TD): a double-blind, randomised, placebo-controlled, phase 3 trial.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Anderson KE,
|
||
Stamler D,
|
||
Davis MD,
|
||
Factor SA,
|
||
Hauser RA,
|
||
Isojärvi J,
|
||
Jarskog LF,
|
||
Jimenez-Shahed J,
|
||
Kumar R,
|
||
McEvoy JP,
|
||
Ochudlo S,
|
||
Ondo WG,
|
||
Fernandez HH</span><br />
|
||
<span class="medgenPMjournal">Lancet Psychiatry</span>
|
||
2017 Aug;4(8):595-604.
|
||
Epub 2017 Jun 28
|
||
doi: 10.1016/S2215-0366(17)30236-5.
|
||
<span class="bold">PMID: </span><a href="/pubmed/28668671" target="_blank">28668671</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Parkinsonism%20with%20favorable%20response%20to%20dopaminergic%20medication%22%20AND%20Etiology%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (23)</a></div><h3 class="subhead">Diagnosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/38967882">Radiosurgical thalamotomy for the management of tremors: a systematic review and meta-analysis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Larcipretti ALL,
|
||
Gomes FC,
|
||
Udoma-Udofa OC,
|
||
Jannotti JBN,
|
||
Bannach MA</span><br />
|
||
<span class="medgenPMjournal">Neurol Sci</span>
|
||
2025 Jan;46(1):79-88.
|
||
Epub 2024 Jul 5
|
||
doi: 10.1007/s10072-024-07670-x.
|
||
<span class="bold">PMID: </span><a href="/pubmed/38967882" target="_blank">38967882</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/29458074">Subthalamic nucleus stimulation, dopaminergic treatment and impulsivity in Parkinson's disease.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Fluchère F,
|
||
Burle B,
|
||
Vidal F,
|
||
van den Wildenberg W,
|
||
Witjas T,
|
||
Eusebio A,
|
||
Azulay JP,
|
||
Hasbroucq T</span><br />
|
||
<span class="medgenPMjournal">Neuropsychologia</span>
|
||
2018 Aug;117:167-177.
|
||
Epub 2018 Feb 16
|
||
doi: 10.1016/j.neuropsychologia.2018.02.016.
|
||
<span class="bold">PMID: </span><a href="/pubmed/29458074" target="_blank">29458074</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/25937616">[(18)F] FP-CIT PET study in parkinsonian patients with leukoaraiosis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Lee MJ,
|
||
Kim SL,
|
||
Kim HI,
|
||
Oh YJ,
|
||
Lee SH,
|
||
Kim HK,
|
||
Han CS,
|
||
Lyoo CH,
|
||
Ryu YH,
|
||
Lee MS</span><br />
|
||
<span class="medgenPMjournal">Parkinsonism Relat Disord</span>
|
||
2015 Jul;21(7):704-8.
|
||
Epub 2015 Apr 20
|
||
doi: 10.1016/j.parkreldis.2015.04.007.
|
||
<span class="bold">PMID: </span><a href="/pubmed/25937616" target="_blank">25937616</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/25659287">Should we irradiate a brain tumor in a patient with parkinsonism? A case report and literature review.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Engelman A,
|
||
Perumal K,
|
||
Mehta M</span><br />
|
||
<span class="medgenPMjournal">Pract Radiat Oncol</span>
|
||
2015 Jul-Aug;5(4):e327-35.
|
||
Epub 2015 Feb 4
|
||
doi: 10.1016/j.prro.2014.12.001.
|
||
<span class="bold">PMID: </span><a href="/pubmed/25659287" target="_blank">25659287</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/11890979">Transcranial magnetic stimulation and Parkinson's disease.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Cantello R,
|
||
Tarletti R,
|
||
Civardi C</span><br />
|
||
<span class="medgenPMjournal">Brain Res Brain Res Rev</span>
|
||
2002 Feb;38(3):309-27.
|
||
doi: 10.1016/s0165-0173(01)00158-8.
|
||
<span class="bold">PMID: </span><a href="/pubmed/11890979" target="_blank">11890979</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Parkinsonism%20with%20favorable%20response%20to%20dopaminergic%20medication%22%20AND%20Diagnosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (7)</a></div><h3 class="subhead">Therapy</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/38070039">The Effects of Safinamide in Chinese and Non-Chinese Patients with Parkinson's Disease.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Cattaneo C,
|
||
Kulisevsky J</span><br />
|
||
<span class="medgenPMjournal">Adv Ther</span>
|
||
2024 Feb;41(2):638-648.
|
||
Epub 2023 Dec 9
|
||
doi: 10.1007/s12325-023-02736-2.
|
||
<span class="bold">PMID: </span><a href="/pubmed/38070039" target="_blank">38070039</a><a href="/pmc/articles/PMC10838837" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/37599424">An update on the pharmacogenetic considerations when prescribing dopamine receptor agonists for Parkinson's disease.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Ayuso P,
|
||
Jiménez-Jiménez FJ,
|
||
Gómez-Tabales J,
|
||
Alonso-Navarro H,
|
||
García-Martín E,
|
||
Agúndez JAG</span><br />
|
||
<span class="medgenPMjournal">Expert Opin Drug Metab Toxicol</span>
|
||
2023 Jul-Dec;19(7):447-460.
|
||
Epub 2023 Aug 24
|
||
doi: 10.1080/17425255.2023.2249404.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37599424" target="_blank">37599424</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/37092235">Structural-Functional Correlates of Response to Pedunculopontine Stimulation in a Randomized Clinical Trial for Axial Symptoms of Parkinson's Disease.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Breit S,
|
||
Milosevic L,
|
||
Naros G,
|
||
Cebi I,
|
||
Weiss D,
|
||
Gharabaghi A</span><br />
|
||
<span class="medgenPMjournal">J Parkinsons Dis</span>
|
||
2023;13(4):563-573.
|
||
doi: 10.3233/JPD-225031.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37092235" target="_blank">37092235</a><a href="/pmc/articles/PMC10357146" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/36402160">Safety and efficacy of continuous subcutaneous foslevodopa-foscarbidopa in patients with advanced Parkinson's disease: a randomised, double-blind, active-controlled, phase 3 trial.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Soileau MJ,
|
||
Aldred J,
|
||
Budur K,
|
||
Fisseha N,
|
||
Fung VS,
|
||
Jeong A,
|
||
Kimber TE,
|
||
Klos K,
|
||
Litvan I,
|
||
O'Neill D,
|
||
Robieson WZ,
|
||
Spindler MA,
|
||
Standaert DG,
|
||
Talapala S,
|
||
Vaou EO,
|
||
Zheng H,
|
||
Facheris MF,
|
||
Hauser RA</span><br />
|
||
<span class="medgenPMjournal">Lancet Neurol</span>
|
||
2022 Dec;21(12):1099-1109.
|
||
doi: 10.1016/S1474-4422(22)00400-8.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36402160" target="_blank">36402160</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/28668671">Deutetrabenazine for treatment of involuntary movements in patients with tardive dyskinesia (AIM-TD): a double-blind, randomised, placebo-controlled, phase 3 trial.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Anderson KE,
|
||
Stamler D,
|
||
Davis MD,
|
||
Factor SA,
|
||
Hauser RA,
|
||
Isojärvi J,
|
||
Jarskog LF,
|
||
Jimenez-Shahed J,
|
||
Kumar R,
|
||
McEvoy JP,
|
||
Ochudlo S,
|
||
Ondo WG,
|
||
Fernandez HH</span><br />
|
||
<span class="medgenPMjournal">Lancet Psychiatry</span>
|
||
2017 Aug;4(8):595-604.
|
||
Epub 2017 Jun 28
|
||
doi: 10.1016/S2215-0366(17)30236-5.
|
||
<span class="bold">PMID: </span><a href="/pubmed/28668671" target="_blank">28668671</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Parkinsonism%20with%20favorable%20response%20to%20dopaminergic%20medication%22%20AND%20Therapy%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (32)</a></div><h3 class="subhead">Prognosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/27190009">Dopamine D2 receptor gene variants and response to rasagiline in early Parkinson's disease: a pharmacogenetic study.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Masellis M,
|
||
Collinson S,
|
||
Freeman N,
|
||
Tampakeras M,
|
||
Levy J,
|
||
Tchelet A,
|
||
Eyal E,
|
||
Berkovich E,
|
||
Eliaz RE,
|
||
Abler V,
|
||
Grossman I,
|
||
Fitzer-Attas C,
|
||
Tiwari A,
|
||
Hayden MR,
|
||
Kennedy JL,
|
||
Lang AE,
|
||
Knight J;
|
||
ADAGIO investigators</span><br />
|
||
<span class="medgenPMjournal">Brain</span>
|
||
2016 Jul;139(Pt 7):2050-62.
|
||
Epub 2016 May 13
|
||
doi: 10.1093/brain/aww109.
|
||
<span class="bold">PMID: </span><a href="/pubmed/27190009" target="_blank">27190009</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/26432343">Intact action segmentation in Parkinson's disease: Hypothesis testing using a novel computational approach.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Schiffer AM,
|
||
Nevado-Holgado AJ,
|
||
Johnen A,
|
||
Schönberger AR,
|
||
Fink GR,
|
||
Schubotz RI</span><br />
|
||
<span class="medgenPMjournal">Neuropsychologia</span>
|
||
2015 Nov;78:29-40.
|
||
Epub 2015 Sep 30
|
||
doi: 10.1016/j.neuropsychologia.2015.09.034.
|
||
<span class="bold">PMID: </span><a href="/pubmed/26432343" target="_blank">26432343</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/25937616">[(18)F] FP-CIT PET study in parkinsonian patients with leukoaraiosis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Lee MJ,
|
||
Kim SL,
|
||
Kim HI,
|
||
Oh YJ,
|
||
Lee SH,
|
||
Kim HK,
|
||
Han CS,
|
||
Lyoo CH,
|
||
Ryu YH,
|
||
Lee MS</span><br />
|
||
<span class="medgenPMjournal">Parkinsonism Relat Disord</span>
|
||
2015 Jul;21(7):704-8.
|
||
Epub 2015 Apr 20
|
||
doi: 10.1016/j.parkreldis.2015.04.007.
|
||
<span class="bold">PMID: </span><a href="/pubmed/25937616" target="_blank">25937616</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/25239603">Randomized, placebo-controlled trial of trimethobenzamide to control nausea and vomiting during initiation and continued treatment with subcutaneous apomorphine injection.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Hauser RA,
|
||
Isaacson S,
|
||
Clinch T;
|
||
Tigan/Apokyn Study Investigators</span><br />
|
||
<span class="medgenPMjournal">Parkinsonism Relat Disord</span>
|
||
2014 Nov;20(11):1171-6.
|
||
Epub 2014 Aug 27
|
||
doi: 10.1016/j.parkreldis.2014.08.010.
|
||
<span class="bold">PMID: </span><a href="/pubmed/25239603" target="_blank">25239603</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/1571080">Comparative efficacy of two oral sustained-release preparations of L-dopa in fluctuating Parkinson's disease. Preliminary findings in 20 patients.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Kleedorfer B,
|
||
Poewe W</span><br />
|
||
<span class="medgenPMjournal">J Neural Transm Park Dis Dement Sect</span>
|
||
1992;4(2):173-8.
|
||
doi: 10.1007/BF02251480.
|
||
<span class="bold">PMID: </span><a href="/pubmed/1571080" target="_blank">1571080</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Parkinsonism%20with%20favorable%20response%20to%20dopaminergic%20medication%22%20AND%20Prognosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (5)</a></div><h3 class="subhead">Clinical prediction guides</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/38967882">Radiosurgical thalamotomy for the management of tremors: a systematic review and meta-analysis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Larcipretti ALL,
|
||
Gomes FC,
|
||
Udoma-Udofa OC,
|
||
Jannotti JBN,
|
||
Bannach MA</span><br />
|
||
<span class="medgenPMjournal">Neurol Sci</span>
|
||
2025 Jan;46(1):79-88.
|
||
Epub 2024 Jul 5
|
||
doi: 10.1007/s10072-024-07670-x.
|
||
<span class="bold">PMID: </span><a href="/pubmed/38967882" target="_blank">38967882</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/32568108">Carbidopa and Levodopa Extended Release Capsules in Patients with and without Troublesome and Non-Troublesome Dyskinesia.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Hauser RA,
|
||
Zeitlin L,
|
||
Fisher S,
|
||
D'Souza R</span><br />
|
||
<span class="medgenPMjournal">J Parkinsons Dis</span>
|
||
2020;10(3):915-925.
|
||
doi: 10.3233/JPD-202010.
|
||
<span class="bold">PMID: </span><a href="/pubmed/32568108" target="_blank">32568108</a><a href="/pmc/articles/PMC7458518" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/28668671">Deutetrabenazine for treatment of involuntary movements in patients with tardive dyskinesia (AIM-TD): a double-blind, randomised, placebo-controlled, phase 3 trial.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Anderson KE,
|
||
Stamler D,
|
||
Davis MD,
|
||
Factor SA,
|
||
Hauser RA,
|
||
Isojärvi J,
|
||
Jarskog LF,
|
||
Jimenez-Shahed J,
|
||
Kumar R,
|
||
McEvoy JP,
|
||
Ochudlo S,
|
||
Ondo WG,
|
||
Fernandez HH</span><br />
|
||
<span class="medgenPMjournal">Lancet Psychiatry</span>
|
||
2017 Aug;4(8):595-604.
|
||
Epub 2017 Jun 28
|
||
doi: 10.1016/S2215-0366(17)30236-5.
|
||
<span class="bold">PMID: </span><a href="/pubmed/28668671" target="_blank">28668671</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/26184442">Different effects of dopaminergic medication on perceptual decision-making in Parkinson's disease as a function of task difficulty and speed-accuracy instructions.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Huang YT,
|
||
Georgiev D,
|
||
Foltynie T,
|
||
Limousin P,
|
||
Speekenbrink M,
|
||
Jahanshahi M</span><br />
|
||
<span class="medgenPMjournal">Neuropsychologia</span>
|
||
2015 Aug;75:577-87.
|
||
Epub 2015 Jul 13
|
||
doi: 10.1016/j.neuropsychologia.2015.07.012.
|
||
<span class="bold">PMID: </span><a href="/pubmed/26184442" target="_blank">26184442</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/25659287">Should we irradiate a brain tumor in a patient with parkinsonism? A case report and literature review.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Engelman A,
|
||
Perumal K,
|
||
Mehta M</span><br />
|
||
<span class="medgenPMjournal">Pract Radiat Oncol</span>
|
||
2015 Jul-Aug;5(4):e327-35.
|
||
Epub 2015 Feb 4
|
||
doi: 10.1016/j.prro.2014.12.001.
|
||
<span class="bold">PMID: </span><a href="/pubmed/25659287" target="_blank">25659287</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Parkinsonism%20with%20favorable%20response%20to%20dopaminergic%20medication%22%20AND%20Clinical%20prediction%20guides%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (17)</a></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_104">
|
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_systematic_reviews">Recent systematic reviews</h1><a sid="104" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln">
|
||
<div class="nl"><a target="_blank" href="/pubmed/38967882">Radiosurgical thalamotomy for the management of tremors: a systematic review and meta-analysis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Larcipretti ALL,
|
||
Gomes FC,
|
||
Udoma-Udofa OC,
|
||
Jannotti JBN,
|
||
Bannach MA</span><br />
|
||
<span class="medgenPMjournal">Neurol Sci</span>
|
||
2025 Jan;46(1):79-88.
|
||
Epub 2024 Jul 5
|
||
doi: 10.1007/s10072-024-07670-x.
|
||
<span class="bold">PMID: </span><a href="/pubmed/38967882" target="_blank">38967882</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/17943771">Bromocriptine versus levodopa in early Parkinson's disease.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">van Hilten JJ,
|
||
Ramaker CC,
|
||
Stowe R,
|
||
Ives NJ</span><br />
|
||
<span class="medgenPMjournal">Cochrane Database Syst Rev</span>
|
||
2007 Oct 17;2007(4):CD002258.
|
||
doi: 10.1002/14651858.CD002258.pub2.
|
||
<span class="bold">PMID: </span><a href="/pubmed/17943771" target="_blank">17943771</a><a href="/pmc/articles/PMC8436728" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/10908538">Bromocriptine versus levodopa in early Parkinson's disease.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Ramaker C,
|
||
van Hilten JJ</span><br />
|
||
<span class="medgenPMjournal">Cochrane Database Syst Rev</span>
|
||
2000;(3):CD002258.
|
||
doi: 10.1002/14651858.CD002258.
|
||
<span class="bold">PMID: </span><a href="/pubmed/10908538" target="_blank">10908538</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Parkinsonism%20with%20favorable%20response%20to%20dopaminergic%20medication%22%20AND%20systematic%5Bsb%5D%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (3)</a></div></div>
|
||
</div>
|
||
</div></div></div></div></div></div></div>
|
||
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<h2 class="offscreen_noflow">Supplemental Content</h2>
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<div class="portlet_content ln"><ul><li><a href="https://clinicaltrials.gov/search?cond=Parkinsonism%20with%20favorable%20response%20to%20dopaminergic%20medication" target="_blank">ClinicalTrials.gov</a></li></ul></div>
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<div class="portlet_content ln"><ul class="a_poppers"><li><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(parkinsonism%20with%20favorable%20response%20to%20dopaminergic%20medication)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">PubMed</a><div class="help-popup">See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div></li></ul></div>
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<a href="/pubmed?term=Parkinsonism%20with%20favorable%20response%20to%20dopaminergic%20medication%20AND%20humans[mesh]%20AND%20review[publication%20type]" ref="ncbi_uid=&discoId=gtr_reviews&linkpos=2&linkpostotal=2" target="_blank">Reviews in PubMed</a>
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<a name="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.HistoryDisplay.ClearHistory" sid="1" realname="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.HistoryDisplay.ClearHistory" cmd="ClearHT" href="?cmd=ClearHT&" onclick="return false;" id="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.HistoryDisplay.ClearHistory">
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