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<!--
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UID=375841
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ConceptID=C1846228
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<!--imgCountBooks = 0--><h1 class="medgenTitle"><div class="MedGenTitleText">Absence of pubertal development</div></h1><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>375841</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1846228</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Finding</dd></dl></div></div><table class="medgenTable"><tbody><tr><td>HPO:</td>
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<td><a target="_blank" title="Human Phenotype Ontology" href="https://hpo.jax.org/app/browse/term/HP:0008197">HP:0008197</a></td></tr>
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<div class="portlet_content ln HierarchyGTR"><div class="jig-ncbitabs"><ul><li><a href="#tabGTR">GTR</a></li><li><a href="#tabMGEN">MeSH</a></li></ul><div id="tabGTR"><div class="search_result"><div class="rprts"><div class="chiclet_legend"><span class="chiclet_list" style="position:static;"><span title="Clinical test" class="chiclet Ccolor round">C</span><span>Clinical test, </span><span title="Research test" class="chiclet Rcolor round">R</span><span>Research test, </span><span title="OMIM" class="chiclet Ocolor ">O</span><span>OMIM, </span><span title="GeneReview" class="chiclet Gcolor">G</span><span><em>GeneReviews</em>, </span><span title="ClinVar" class="chiclet Vcolor">V</span><span>ClinVar </span></span></div><div id="hierarchy" class="margin_t1"><div class="ds_tree"><ul><li class="matched_ds"><span class="chiclet_list"><span class="chiclet unavailable round" title="Clinical test">C</span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet unavailable" title="OMIM">O</span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet unavailable" title="ClinVar">V</span></span><span class="TLline">Absence of pubertal development</span></li></ul></div></div></div></div></div><div id="tabMGEN"><div class="ds_tree"><ul><li><span class="TLline"><a href="/medgen/867443" ref="tree=MeSH" title="MedGen record for Phenotypic abnormality">Phenotypic abnormality</a></span><ul><li><span class="TLline"><a href="/medgen/893021" ref="tree=MeSH" title="MedGen record for Abnormality of the endocrine system">Abnormality of the endocrine system</a></span><ul><li><span class="TLline"><a href="/medgen/870247" ref="tree=MeSH" title="MedGen record for Puberty and gonadal disorders">Puberty and gonadal disorders</a></span><ul><li><span class="matched_ds">Absence of pubertal development</span><ul><li><span class="TLline"><a href="/medgen/870212" ref="tree=MeSH" title="MedGen record for Pubertal developmental failure in females">Pubertal developmental failure in females</a></span></li></ul></li></ul></li></ul></li></ul></li></ul></div></div></div></div>
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Conditions_with_this_feature">Conditions with this feature</h1><a sid="112" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="portlet_content ln clinfeat">
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<div class="divPopper rprt" id="rdis_78602"><div><strong>46,XY sex reversal 11</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>78602</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0266427</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">SRXY11 is characterized by a genital phenotype that may range from predominantly female to predominantly male, including marked sex ambiguity depending on the duration of normal testicular function prior to the loss of testicular tissue. Approximately half of patients present with micropenis and bilateral cryptorchidism, and half present with female-appearing or ambiguous external genitalia (da Silva et al., 2019; McElreavey et al., 2020). The testicular regression syndrome (TRS) was delineated by Sarto and Opitz (1973), who called it the XY gonadal dysgenesis syndrome. It is characterized primarily by the absence of gonads in an XY person. In most cases, uterus and fallopian tubes are absent but small tubular structures interpreted as mullerian or wolffian rudiments (or both) are present. The range of virilizing effects due to early testicular tissue extends from none in phenotypic females with only slightly hypoplastic normal external genitalia, well-formed but hypoplastic uterus, and well-formed tubes (De Marchi et al., 1981) to the anorchic phenotypic male (Edman et al., 1977). Most affected individuals lack a vagina but a urogenital sinus or pseudovaginal urethral outpouching is found. Partial labioscrotal fusion and clitoris enlargement are common, breast development is absent, and postpubertal eunuchoid habitus is the rule. Sometimes nongenital anomalies are present (summary by Rosenberg et al., 1984).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/78602">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_87442"><div><strong>Congenital adrenal hypoplasia, X-linked</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>87442</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information."><span class="highlight" style="background-color:">C0342482</span></a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">NR0B1-related adrenal hypoplasia congenita includes both X-linked adrenal hypoplasia congenita (X-linked AHC) and Xp21 deletion (previously called complex glycerol kinase deficiency). X-linked AHC is characterized by primary adrenal insufficiency and/or hypogonadotropic hypogonadism (HH). Adrenal insufficiency is acute infantile onset (average age 3 weeks) in approximately 60% of affected males and childhood onset (ages 1-9 years) in approximately 40%. HH typically manifests in a male with adrenal insufficiency as delayed puberty (i.e., onset age >14 years) and less commonly as arrested puberty at about Tanner Stage 3. Rarely, X-linked AHC manifests initially in early adulthood as delayed-onset adrenal insufficiency, partial HH, and/or infertility. Heterozygous females very occasionally have manifestations of adrenal insufficiency or hypogonadotropic hypogonadism. Xp21 deletion includes deletion of NR0B1 (causing X-linked AHC) and GK (causing glycerol kinase deficiency), and in some cases deletion of DMD (causing Duchenne muscular dystrophy). Developmental delay has been reported in males with Xp21 deletion when the deletion extends proximally to include DMD or when larger deletions extend distally to include IL1RAPL1 and DMD.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/87442">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_349137"><div><strong>Cerebellar ataxia-hypogonadism syndrome</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>349137</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1859305</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">PNPLA6 disorders span a phenotypic continuum characterized by variable combinations of cerebellar ataxia; upper motor neuron involvement manifesting as spasticity and/or brisk reflexes; chorioretinal dystrophy associated with variable degrees of reduced visual function; and hypogonadotropic hypogonadism (delayed puberty and lack of secondary sex characteristics). The hypogonadotropic hypogonadism occurs either in isolation or as part of anterior hypopituitarism (growth hormone, thyroid hormone, or gonadotropin deficiencies). Common but less frequent features are peripheral neuropathy (usually of axonal type manifesting as reduced distal reflexes, diminished vibratory sensation, and/or distal muscle wasting); hair anomalies (long eyelashes, bushy eyebrows, or scalp alopecia); short stature; and impaired cognitive functioning (learning disabilities in children; deficits in attention, visuospatial abilities, and recall in adults). Some of these features can occur in distinct clusters on the phenotypic continuum: Boucher-Neuhäuser syndrome (cerebellar ataxia, chorioretinal dystrophy, and hypogonadotropic hypogonadism); Gordon Holmes syndrome (cerebellar ataxia, hypogonadotropic hypogonadism, and – to a variable degree – brisk reflexes); Oliver-McFarlane syndrome (trichomegaly, chorioretinal dystrophy, short stature, intellectual disability, and hypopituitarism); Laurence-Moon syndrome; and spastic paraplegia type 39 (SPG39) (upper motor neuron involvement, peripheral neuropathy, and sometimes reduced cognitive functioning and/or cerebellar ataxia).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/349137">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_765257"><div><strong>Hypogonadotropic hypogonadism 4 with or without anosmia</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>765257</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C3552343</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Isolated gonadotropin-releasing hormone (GnRH) deficiency (IGD) is characterized by inappropriately low serum concentrations of the gonadotropins LH (luteinizing hormone) and FSH (follicle-stimulating hormone) in the presence of low circulating concentrations of sex steroids. IGD is associated with a normal sense of smell (normosmic IGD) in approximately 40% of affected individuals and an impaired sense of smell (Kallmann syndrome) in approximately 60%. IGD can first become apparent in infancy, adolescence, or adulthood. Infant boys with congenital IGD often have micropenis and cryptorchidism. Adolescents and adults with IGD have clinical evidence of hypogonadism and incomplete sexual maturation on physical examination. Adult males with IGD tend to have prepubertal testicular volume (i.e., <4 mL), absence of secondary sexual features (e.g., facial and axillary hair growth, deepening of the voice), decreased muscle mass, diminished libido, erectile dysfunction, and infertility. Adult females have little or no breast development and primary amenorrhea. Although skeletal maturation is delayed, the rate of linear growth is usually normal except for the absence of a distinct pubertal growth spurt.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/765257">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_766755"><div><strong>Hypogonadotropic hypogonadism 8 with or without anosmia</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>766755</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C3553841</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Isolated gonadotropin-releasing hormone (GnRH) deficiency (IGD) is characterized by inappropriately low serum concentrations of the gonadotropins LH (luteinizing hormone) and FSH (follicle-stimulating hormone) in the presence of low circulating concentrations of sex steroids. IGD is associated with a normal sense of smell (normosmic IGD) in approximately 40% of affected individuals and an impaired sense of smell (Kallmann syndrome) in approximately 60%. IGD can first become apparent in infancy, adolescence, or adulthood. Infant boys with congenital IGD often have micropenis and cryptorchidism. Adolescents and adults with IGD have clinical evidence of hypogonadism and incomplete sexual maturation on physical examination. Adult males with IGD tend to have prepubertal testicular volume (i.e., <4 mL), absence of secondary sexual features (e.g., facial and axillary hair growth, deepening of the voice), decreased muscle mass, diminished libido, erectile dysfunction, and infertility. Adult females have little or no breast development and primary amenorrhea. Although skeletal maturation is delayed, the rate of linear growth is usually normal except for the absence of a distinct pubertal growth spurt.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/766755">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_766758"><div><strong>Hypogonadotropic hypogonadism 11 with or without anosmia</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>766758</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C3553844</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Isolated gonadotropin-releasing hormone (GnRH) deficiency (IGD) is characterized by inappropriately low serum concentrations of the gonadotropins LH (luteinizing hormone) and FSH (follicle-stimulating hormone) in the presence of low circulating concentrations of sex steroids. IGD is associated with a normal sense of smell (normosmic IGD) in approximately 40% of affected individuals and an impaired sense of smell (Kallmann syndrome) in approximately 60%. IGD can first become apparent in infancy, adolescence, or adulthood. Infant boys with congenital IGD often have micropenis and cryptorchidism. Adolescents and adults with IGD have clinical evidence of hypogonadism and incomplete sexual maturation on physical examination. Adult males with IGD tend to have prepubertal testicular volume (i.e., <4 mL), absence of secondary sexual features (e.g., facial and axillary hair growth, deepening of the voice), decreased muscle mass, diminished libido, erectile dysfunction, and infertility. Adult females have little or no breast development and primary amenorrhea. Although skeletal maturation is delayed, the rate of linear growth is usually normal except for the absence of a distinct pubertal growth spurt.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/766758">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_815305"><div><strong>Hypogonadotropic hypogonadism 18 with or without anosmia</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>815305</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C3808975</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Isolated gonadotropin-releasing hormone (GnRH) deficiency (IGD) is characterized by inappropriately low serum concentrations of the gonadotropins LH (luteinizing hormone) and FSH (follicle-stimulating hormone) in the presence of low circulating concentrations of sex steroids. IGD is associated with a normal sense of smell (normosmic IGD) in approximately 40% of affected individuals and an impaired sense of smell (Kallmann syndrome) in approximately 60%. IGD can first become apparent in infancy, adolescence, or adulthood. Infant boys with congenital IGD often have micropenis and cryptorchidism. Adolescents and adults with IGD have clinical evidence of hypogonadism and incomplete sexual maturation on physical examination. Adult males with IGD tend to have prepubertal testicular volume (i.e., <4 mL), absence of secondary sexual features (e.g., facial and axillary hair growth, deepening of the voice), decreased muscle mass, diminished libido, erectile dysfunction, and infertility. Adult females have little or no breast development and primary amenorrhea. Although skeletal maturation is delayed, the rate of linear growth is usually normal except for the absence of a distinct pubertal growth spurt.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/815305">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_1648307"><div><strong>Ovarian dysgenesis 6</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1648307</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C4748084</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Ovarian dysgenesis-6 (ODG6) is characterized by absence of spontaneous pubertal development in females with elevated gonadotropin levels, small uterus, and small or absent ovaries on imaging studies. Males appear to be unaffected (Weinberg-Shukron et al., 2015; Tucker et al., 2022). For a discussion of genetic heterogeneity of ovarian dysgenesis, see ODG1 (233300).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1648307">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_1810165"><div><strong>Hypogonadotropic hypogonadism 27 without anosmia</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1810165</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C5676921</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Hypogonadotropic hypogonadism-27 without anosmia (HH27) is characterized by lack of pubertal development associated with onset of obesity in early adolescence (Topaloglu et al., 2022). Congenital idiopathic hypogonadotropic hypogonadism (IHH) is a disorder characterized by absent or incomplete sexual maturation by the age of 18 years, in conjunction with low levels of circulating gonadotropins and testosterone and no other abnormalities of the hypothalamic-pituitary axis. Idiopathic hypogonadotropic hypogonadism can be caused by an isolated defect in gonadotropin-releasing hormone (GNRH; 152760) release, action, or both. Other associated nonreproductive phenotypes, such as anosmia, cleft palate, and sensorineural hearing loss, occur with variable frequency. In the presence of anosmia, idiopathic hypogonadotropic hypogonadism has been called 'Kallmann syndrome (KS),' whereas in the presence of a normal sense of smell, it has been termed 'normosmic idiopathic hypogonadotropic hypogonadism (nIHH)' (summary by Raivio et al., 2007). Because families have been found to segregate both KS and nIHH, the disorder is here referred to as 'hypogonadotropic hypogonadism with or without anosmia (HH).'</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1810165">Condition Record</a></div></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_78602" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">46,XY sex reversal 11</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_349137" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Cerebellar ataxia-hypogonadism syndrome</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_87442" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Congenital adrenal hypoplasia, X-linked</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_766758" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Hypogonadotropic hypogonadism 11 with or without anosmia</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_815305" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Hypogonadotropic hypogonadism 18 with or without anosmia</a></div><div class="jig-moreless" data-jigconfig="class: 'moveDown', moreText: 'See full list (9)', lessText: 'Show less', nodeBefore: 0"><span id="clinMore">
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1810165" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Hypogonadotropic hypogonadism 27 without anosmia</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_765257" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Hypogonadotropic hypogonadism 4 with or without anosmia</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_766755" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Hypogonadotropic hypogonadism 8 with or without anosmia</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1648307" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Ovarian dysgenesis 6</a></div></span></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_105">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Professional_guidelines">Professional guidelines</h1><a sid="105" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">PubMed<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpPM"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/14671394">Ascertainment and treatment of delayed puberty.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Pozo J,
|
||
Argente J</span><br />
|
||
<span class="medgenPMjournal">Horm Res</span>
|
||
2003;60 Suppl 3:35-48.
|
||
doi: 10.1159/000074498.
|
||
<span class="bold">PMID: </span><a href="/pubmed/14671394" target="_blank">14671394</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(%22absence%20of%20pubertal%20development%22%5Btiab%3A~0%5D)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">See all (1)</a></div></div>
|
||
</div>
|
||
<div class="display-none help-popup" id="guidelinesHelpPM">These guidelines are articles in PubMed that match specific search criteria developed by MedGen to capture the most relevant practice guidelines. This list may not be comprehensive and may include broader topics as well. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div><div class="display-none help-popup" id="guidelinesHelpCurated">These guidelines are manually curated by the MedGen team
|
||
to supplement articles available in PubMed. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div>
|
||
<div class="portlet mgSection" id="ID_103">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_clinical_studies">Recent clinical studies</h1><a sid="103" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">Etiology</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/38532895">Cryptorchidism and puberty.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Rodprasert W,
|
||
Virtanen HE,
|
||
Toppari J</span><br />
|
||
<span class="medgenPMjournal">Front Endocrinol (Lausanne)</span>
|
||
2024;15:1347435.
|
||
Epub 2024 Mar 12
|
||
doi: 10.3389/fendo.2024.1347435.
|
||
<span class="bold">PMID: </span><a href="/pubmed/38532895" target="_blank">38532895</a><a href="/pmc/articles/PMC10963523" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/38116311">Reproductive health in Turner's syndrome: from puberty to pregnancy.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Porcu E,
|
||
Cipriani L,
|
||
Damiano G</span><br />
|
||
<span class="medgenPMjournal">Front Endocrinol (Lausanne)</span>
|
||
2023;14:1269009.
|
||
Epub 2023 Dec 5
|
||
doi: 10.3389/fendo.2023.1269009.
|
||
<span class="bold">PMID: </span><a href="/pubmed/38116311" target="_blank">38116311</a><a href="/pmc/articles/PMC10728473" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/36545774">Pediatric Inflammatory Bowel Disease.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Bouhuys M,
|
||
Lexmond WS,
|
||
van Rheenen PF</span><br />
|
||
<span class="medgenPMjournal">Pediatrics</span>
|
||
2023 Jan 1;151(1)
|
||
doi: 10.1542/peds.2022-058037.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36545774" target="_blank">36545774</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/31259490">Amenorrhea: A Systematic Approach to Diagnosis and Management.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Klein DA,
|
||
Paradise SL,
|
||
Reeder RM</span><br />
|
||
<span class="medgenPMjournal">Am Fam Physician</span>
|
||
2019 Jul 1;100(1):39-48.
|
||
<span class="bold">PMID: </span><a href="/pubmed/31259490" target="_blank">31259490</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/17708142">Turner syndrome: diagnosis and management.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Morgan T</span><br />
|
||
<span class="medgenPMjournal">Am Fam Physician</span>
|
||
2007 Aug 1;76(3):405-10.
|
||
<span class="bold">PMID: </span><a href="/pubmed/17708142" target="_blank">17708142</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Absence%20of%20pubertal%20development%22%20AND%20Etiology%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (165)</a></div><h3 class="subhead">Diagnosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/37300628">Androgen insensitivity syndrome: a review.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Delli Paoli E,
|
||
Di Chiano S,
|
||
Paoli D,
|
||
Lenzi A,
|
||
Lombardo F,
|
||
Pallotti F</span><br />
|
||
<span class="medgenPMjournal">J Endocrinol Invest</span>
|
||
2023 Nov;46(11):2237-2245.
|
||
Epub 2023 Jun 10
|
||
doi: 10.1007/s40618-023-02127-y.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37300628" target="_blank">37300628</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/37127825">Delayed Puberty.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Mohanraj S,
|
||
Prasad HK</span><br />
|
||
<span class="medgenPMjournal">Indian J Pediatr</span>
|
||
2023 Jun;90(6):590-597.
|
||
Epub 2023 May 2
|
||
doi: 10.1007/s12098-023-04577-x.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37127825" target="_blank">37127825</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/36545774">Pediatric Inflammatory Bowel Disease.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Bouhuys M,
|
||
Lexmond WS,
|
||
van Rheenen PF</span><br />
|
||
<span class="medgenPMjournal">Pediatrics</span>
|
||
2023 Jan 1;151(1)
|
||
doi: 10.1542/peds.2022-058037.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36545774" target="_blank">36545774</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/32748610">Delayed puberty.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Butler G,
|
||
Purushothaman P</span><br />
|
||
<span class="medgenPMjournal">Minerva Pediatr</span>
|
||
2020 Dec;72(6):484-490.
|
||
Epub 2020 Aug 4
|
||
doi: 10.23736/S0026-4946.20.05968-X.
|
||
<span class="bold">PMID: </span><a href="/pubmed/32748610" target="_blank">32748610</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/31259490">Amenorrhea: A Systematic Approach to Diagnosis and Management.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Klein DA,
|
||
Paradise SL,
|
||
Reeder RM</span><br />
|
||
<span class="medgenPMjournal">Am Fam Physician</span>
|
||
2019 Jul 1;100(1):39-48.
|
||
<span class="bold">PMID: </span><a href="/pubmed/31259490" target="_blank">31259490</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Absence%20of%20pubertal%20development%22%20AND%20Diagnosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (119)</a></div><h3 class="subhead">Therapy</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/35623621">Polycystic Ovary Syndrome in Adolescence: Challenges in Diagnosis and Management.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Manique MES,
|
||
Ferreira AMAP</span><br />
|
||
<span class="medgenPMjournal">Rev Bras Ginecol Obstet</span>
|
||
2022 Apr;44(4):425-433.
|
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Epub 2022 May 27
|
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|
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<span class="bold">PMID: </span><a href="/pubmed/35623621" target="_blank">35623621</a><a href="/pmc/articles/PMC9948137" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/34975773">Should Skeletal Maturation Be Manipulated for Extra Height Gain?</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Wit JM</span><br />
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<span class="medgenPMjournal">Front Endocrinol (Lausanne)</span>
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2021;12:812196.
|
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Epub 2021 Dec 16
|
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doi: 10.3389/fendo.2021.812196.
|
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<span class="bold">PMID: </span><a href="/pubmed/34975773" target="_blank">34975773</a><a href="/pmc/articles/PMC8716689" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
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|
||
<div class="nl"><a target="_blank" href="/pubmed/29779582">Animal models of endocrine disruption.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Patisaul HB,
|
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Fenton SE,
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Aylor D</span><br />
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<span class="medgenPMjournal">Best Pract Res Clin Endocrinol Metab</span>
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2018 Jun;32(3):283-297.
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|
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<span class="bold">PMID: </span><a href="/pubmed/29779582" target="_blank">29779582</a><a href="/pmc/articles/PMC6029710" target="_blank" class="PubMedFree">Free PMC Article</a></div>
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<div class="nl"><a target="_blank" href="/pubmed/17708142">Turner syndrome: diagnosis and management.</a></div>
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<span class="medgenPMjournal">Am Fam Physician</span>
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<div class="nl"><a target="_blank" href="/pubmed/6379175">Adolescent menstrual irregularity.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Mansfield MJ,
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<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Absence%20of%20pubertal%20development%22%20AND%20Therapy%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (73)</a></div><h3 class="subhead">Prognosis</h3>
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<div class="nl"><a target="_blank" href="/pubmed/37127825">Delayed Puberty.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Mohanraj S,
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Prasad HK</span><br />
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2023 Jun;90(6):590-597.
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Epub 2023 May 2
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doi: 10.1007/s12098-023-04577-x.
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<span class="bold">PMID: </span><a href="/pubmed/37127825" target="_blank">37127825</a></div>
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<div class="nl"><a target="_blank" href="/pubmed/36545774">Pediatric Inflammatory Bowel Disease.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Bouhuys M,
|
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Lexmond WS,
|
||
van Rheenen PF</span><br />
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||
<span class="medgenPMjournal">Pediatrics</span>
|
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2023 Jan 1;151(1)
|
||
doi: 10.1542/peds.2022-058037.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36545774" target="_blank">36545774</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/36339428">Precocious puberty and microbiota: The role of the sex hormone-gut microbiome axis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Calcaterra V,
|
||
Rossi V,
|
||
Massini G,
|
||
Regalbuto C,
|
||
Hruby C,
|
||
Panelli S,
|
||
Bandi C,
|
||
Zuccotti G</span><br />
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<span class="medgenPMjournal">Front Endocrinol (Lausanne)</span>
|
||
2022;13:1000919.
|
||
Epub 2022 Oct 21
|
||
doi: 10.3389/fendo.2022.1000919.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36339428" target="_blank">36339428</a><a href="/pmc/articles/PMC9634744" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/34975773">Should Skeletal Maturation Be Manipulated for Extra Height Gain?</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Wit JM</span><br />
|
||
<span class="medgenPMjournal">Front Endocrinol (Lausanne)</span>
|
||
2021;12:812196.
|
||
Epub 2021 Dec 16
|
||
doi: 10.3389/fendo.2021.812196.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34975773" target="_blank">34975773</a><a href="/pmc/articles/PMC8716689" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/32748610">Delayed puberty.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Butler G,
|
||
Purushothaman P</span><br />
|
||
<span class="medgenPMjournal">Minerva Pediatr</span>
|
||
2020 Dec;72(6):484-490.
|
||
Epub 2020 Aug 4
|
||
doi: 10.23736/S0026-4946.20.05968-X.
|
||
<span class="bold">PMID: </span><a href="/pubmed/32748610" target="_blank">32748610</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Absence%20of%20pubertal%20development%22%20AND%20Prognosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (79)</a></div><h3 class="subhead">Clinical prediction guides</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/36545774">Pediatric Inflammatory Bowel Disease.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Bouhuys M,
|
||
Lexmond WS,
|
||
van Rheenen PF</span><br />
|
||
<span class="medgenPMjournal">Pediatrics</span>
|
||
2023 Jan 1;151(1)
|
||
doi: 10.1542/peds.2022-058037.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36545774" target="_blank">36545774</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/36339428">Precocious puberty and microbiota: The role of the sex hormone-gut microbiome axis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Calcaterra V,
|
||
Rossi V,
|
||
Massini G,
|
||
Regalbuto C,
|
||
Hruby C,
|
||
Panelli S,
|
||
Bandi C,
|
||
Zuccotti G</span><br />
|
||
<span class="medgenPMjournal">Front Endocrinol (Lausanne)</span>
|
||
2022;13:1000919.
|
||
Epub 2022 Oct 21
|
||
doi: 10.3389/fendo.2022.1000919.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36339428" target="_blank">36339428</a><a href="/pmc/articles/PMC9634744" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/36187104">MKRN3 role in regulating pubertal onset: the state of art of functional studies.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Palumbo S,
|
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Cirillo G,
|
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Aiello F,
|
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Papparella A,
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Miraglia Del Giudice E,
|
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Grandone A</span><br />
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<span class="medgenPMjournal">Front Endocrinol (Lausanne)</span>
|
||
2022;13:991322.
|
||
Epub 2022 Sep 16
|
||
doi: 10.3389/fendo.2022.991322.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36187104" target="_blank">36187104</a><a href="/pmc/articles/PMC9523110" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/34975773">Should Skeletal Maturation Be Manipulated for Extra Height Gain?</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Wit JM</span><br />
|
||
<span class="medgenPMjournal">Front Endocrinol (Lausanne)</span>
|
||
2021;12:812196.
|
||
Epub 2021 Dec 16
|
||
doi: 10.3389/fendo.2021.812196.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34975773" target="_blank">34975773</a><a href="/pmc/articles/PMC8716689" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/32748610">Delayed puberty.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Butler G,
|
||
Purushothaman P</span><br />
|
||
<span class="medgenPMjournal">Minerva Pediatr</span>
|
||
2020 Dec;72(6):484-490.
|
||
Epub 2020 Aug 4
|
||
doi: 10.23736/S0026-4946.20.05968-X.
|
||
<span class="bold">PMID: </span><a href="/pubmed/32748610" target="_blank">32748610</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Absence%20of%20pubertal%20development%22%20AND%20Clinical%20prediction%20guides%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (130)</a></div></div>
|
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|
||
|
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<div class="portlet mgSection" id="ID_104">
|
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_systematic_reviews">Recent systematic reviews</h1><a sid="104" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln">
|
||
<div class="nl"><a target="_blank" href="/pubmed/38716247">Determinants of central obesity in children and adolescents and associated complications in South Africa: a systematic review.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Ntimana CB,
|
||
Seakamela KP,
|
||
Mashaba RG,
|
||
Maimela E</span><br />
|
||
<span class="medgenPMjournal">Front Public Health</span>
|
||
2024;12:1324855.
|
||
Epub 2024 Apr 23
|
||
doi: 10.3389/fpubh.2024.1324855.
|
||
<span class="bold">PMID: </span><a href="/pubmed/38716247" target="_blank">38716247</a><a href="/pmc/articles/PMC11075369" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/37576960">Abnormalities of pubertal development and gonadal function in Noonan syndrome.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Patti G,
|
||
Scaglione M,
|
||
Maiorano NG,
|
||
Rosti G,
|
||
Divizia MT,
|
||
Camia T,
|
||
De Rose EL,
|
||
Zucconi A,
|
||
Casalini E,
|
||
Napoli F,
|
||
Di Iorgi N,
|
||
Maghnie M</span><br />
|
||
<span class="medgenPMjournal">Front Endocrinol (Lausanne)</span>
|
||
2023;14:1213098.
|
||
Epub 2023 Jul 28
|
||
doi: 10.3389/fendo.2023.1213098.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37576960" target="_blank">37576960</a><a href="/pmc/articles/PMC10422880" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/36506059">Secular trends in age at pubertal onset assessed by breast development among Chinese girls: A systematic review.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Shu W,
|
||
Zong X,
|
||
Li H</span><br />
|
||
<span class="medgenPMjournal">Front Endocrinol (Lausanne)</span>
|
||
2022;13:1042122.
|
||
Epub 2022 Nov 24
|
||
doi: 10.3389/fendo.2022.1042122.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36506059" target="_blank">36506059</a><a href="/pmc/articles/PMC9729541" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/34566884">Early-Life Exposure to Per- and Poly-Fluorinated Alkyl Substances and Growth, Adiposity, and Puberty in Children: A Systematic Review.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Lee YJ,
|
||
Jung HW,
|
||
Kim HY,
|
||
Choi YJ,
|
||
Lee YA</span><br />
|
||
<span class="medgenPMjournal">Front Endocrinol (Lausanne)</span>
|
||
2021;12:683297.
|
||
Epub 2021 Sep 9
|
||
doi: 10.3389/fendo.2021.683297.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34566884" target="_blank">34566884</a><a href="/pmc/articles/PMC8458955" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/26542164">Sex Differences in Landing Biomechanics and Postural Stability During Adolescence: A Systematic Review with Meta-Analyses.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Holden S,
|
||
Boreham C,
|
||
Delahunt E</span><br />
|
||
<span class="medgenPMjournal">Sports Med</span>
|
||
2016 Feb;46(2):241-53.
|
||
doi: 10.1007/s40279-015-0416-6.
|
||
<span class="bold">PMID: </span><a href="/pubmed/26542164" target="_blank">26542164</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Absence%20of%20pubertal%20development%22%20AND%20systematic%5Bsb%5D%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (5)</a></div></div>
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|
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<div class="portlet_content ln"><ul class="a_poppers"><li><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(%22absence%20of%20pubertal%20development%22%5Btiab%3A~0%5D)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">PubMed</a><div class="help-popup">See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div></li><li><a target="_blank" href="/books/?term=((%22clinical%20guidelines%22%5BResource%20Type%5D)%20OR%20%22practice%20guideline%22%5BPublication%20Type%5D)%20AND%20(%22Absence%20of%20pubertal%20development%22)">Bookshelf</a><div class="help-popup">See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div></li></ul></div>
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