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103 KiB
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<!--
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UID=21294
|
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ConceptID=C0038018
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<!--imgCountBooks = 0--><h1 class="medgenTitle"><div class="MedGenTitleText">Spondylolysis</div></h1><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>21294</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0038018</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div><table class="medgenTable"><tbody><tr><td>Synonym:</td>
|
||
<td>Spondylolyses</td></tr>
|
||
<tr><td><span class="bold">SNOMED CT: </span></td>
|
||
<td>Spondylolysis (240221008)</td></tr>
|
||
<tr><td colspan="2" class="small"> </td></tr><tr><td>HPO:</td>
|
||
<td><a target="_blank" title="Human Phenotype Ontology" href="https://hpo.jax.org/app/browse/term/HP:0003304">HP:0003304</a></td></tr>
|
||
<tr><td>Monarch Initiative:</td>
|
||
<td><a href="https://monarchinitiative.org/disease/MONDO:0005541" target="_blank">MONDO:0005541</a></td></tr>
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Definition">Definition</h1><a sid="100" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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||
<div class="portlet_content ln">Spondylolysis is an osseous defect of the pars interarticularis, thought to be a developmental or acquired stress fracture secondary to chronic low-grade trauma. [from <a title="Human Phenotype Ontology" href="http://www.human-phenotype-ontology.org" class="defSource" target="_blank">HPO</a>]</div>
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Term_Hierarchy">Term Hierarchy</h1><a sid="118" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="portlet_content ln HierarchyGTR"><div class="jig-ncbitabs"><ul><li><a href="#tabGTR">GTR</a></li><li><a href="#tabMGEN">MeSH</a></li></ul><div id="tabGTR"><div class="search_result"><div class="rprts"><div class="chiclet_legend"><span class="chiclet_list" style="position:static;"><span title="Clinical test" class="chiclet Ccolor round">C</span><span>Clinical test, </span><span title="Research test" class="chiclet Rcolor round">R</span><span>Research test, </span><span title="OMIM" class="chiclet Ocolor ">O</span><span>OMIM, </span><span title="GeneReview" class="chiclet Gcolor">G</span><span><em>GeneReviews</em>, </span><span title="ClinVar" class="chiclet Vcolor">V</span><span>ClinVar </span></span></div><div id="hierarchy" class="margin_t1"><div class="ds_tree"><ul><li class="matched_ds"><span class="chiclet_list"><span class="chiclet unavailable round" title="Clinical test">C</span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet unavailable" title="OMIM">O</span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet unavailable" title="ClinVar">V</span></span><span class="TLline">Spondylolysis</span></li></ul></div></div></div></div></div><div id="tabMGEN"><div class="ds_tree"><ul><li><span class="TLline"><a href="/medgen/867443" ref="tree=MeSH" title="MedGen record for Phenotypic abnormality">Phenotypic abnormality</a></span><ul><li><span class="TLline"><a href="/medgen/1763488" ref="tree=MeSH" title="MedGen record for Abnormality of the musculoskeletal system">Abnormality of the musculoskeletal system</a></span><ul><li><span class="TLline"><a href="/medgen/867418" ref="tree=MeSH" title="MedGen record for Abnormality of the skeletal system">Abnormality of the skeletal system</a></span><ul><li><span class="TLline"><a href="/medgen/868760" ref="tree=MeSH" title="MedGen record for Abnormal skeletal morphology">Abnormal skeletal morphology</a></span><ul><li><span class="TLline"><a href="/medgen/892434" ref="tree=MeSH" title="MedGen record for Abnormal axial skeleton morphology">Abnormal axial skeleton morphology</a></span><ul><li><span class="TLline"><a href="/medgen/892426" ref="tree=MeSH" title="MedGen record for Abnormality of the vertebral column">Abnormality of the vertebral column</a></span><ul><li><span class="matched_ds">Spondylolysis</span><ul><li><span class="TLline"><a href="/medgen/163399" ref="tree=MeSH" title="MedGen record for Congenital spondylolysis">Congenital spondylolysis</a></span><ul><li><span class="TLline"><a href="/medgen/96576" ref="tree=MeSH" title="MedGen record for Congenital spondylolysis of lumbosacral region">Congenital spondylolysis of lumbosacral region</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/52470" ref="tree=MeSH" title="MedGen record for Spondylolisthesis">Spondylolisthesis</a></span><ul><li><span class="TLline"><a href="/medgen/477430" ref="tree=MeSH" title="MedGen record for Spondylolisthesis at L5-S1">Spondylolisthesis at L5-S1</a></span></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></div></div></div></div>
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<div class="portlet mgSection" id="ID_112">
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||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Conditions_with_this_feature">Conditions with this feature</h1><a sid="112" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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||
<div class="portlet_content ln clinfeat">
|
||
<div class="divPopper rprt" id="rdis_3486"><div><strong>Cleidocranial dysostosis</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>3486</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0008928</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Cleidocranial dysplasia (CCD) spectrum disorder is a skeletal dysplasia that represents a clinical continuum ranging from classic CCD (triad of delayed closure of the cranial sutures, hypoplastic or aplastic clavicles, and dental abnormalities), to mild CCD, to isolated dental anomalies without other skeletal features. Individuals with classic CCD spectrum disorder typically have abnormally large, wide-open fontanelles at birth that may remain open throughout life. Clavicular hypoplasia can result in narrow, sloping shoulders that can be opposed at the midline. Moderate short stature may be observed, with most affected individuals being shorter than their unaffected sibs. Dental anomalies may include delayed eruption of secondary dentition, failure to shed the primary teeth, and supernumerary teeth. Individuals with CCD spectrum disorder are at increased risk of developing recurrent sinus infections, recurrent ear infections leading to conductive hearing loss, and upper airway obstruction. Intelligence is typically normal.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/3486">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_52470"><div><strong>Spondylolisthesis</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>52470</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0038016</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Spondylolisthesis is defined as forward slipping of a vertebral body on the one below it. Spondylolysis is defined as a defect in the pars interarticularis without vertebral slipping (summary by Wiltse et al., 1975).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/52470">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_104500"><div><strong>Larsen syndrome</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>104500</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0175778</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">The FLNB disorders include a spectrum of phenotypes ranging from mild to severe. At the mild end are spondylocarpotarsal synostosis (SCT) syndrome and Larsen syndrome; at the severe end are the phenotypic continuum of atelosteogenesis types I (AOI) and III (AOIII) and Piepkorn osteochondrodysplasia (POCD). SCT syndrome is characterized by postnatal disproportionate short stature, scoliosis and lordosis, clubfeet, hearing loss, dental enamel hypoplasia, carpal and tarsal synostosis, and vertebral fusions. Larsen syndrome is characterized by congenital dislocations of the hip, knee, and elbow; clubfeet (equinovarus or equinovalgus foot deformities); scoliosis and cervical kyphosis, which can be associated with a cervical myelopathy; short, broad, spatulate distal phalanges; distinctive craniofacies (prominent forehead, depressed nasal bridge, malar flattening, and widely spaced eyes); vertebral anomalies; and supernumerary carpal and tarsal bone ossification centers. Individuals with SCT syndrome and Larsen syndrome can have midline cleft palate and hearing loss. AOI and AOIII are characterized by severe short-limbed dwarfism; dislocated hips, knees, and elbows; and clubfeet. AOI is lethal in the perinatal period. In individuals with AOIII, survival beyond the neonatal period is possible with intensive and invasive respiratory support. Piepkorn osteochondrodysplasia (POCD) is a perinatal-lethal micromelic dwarfism characterized by flipper-like limbs (polysyndactyly with complete syndactyly of all fingers and toes, hypoplastic or absent first digits, and duplicated intermediate and distal phalanges), macrobrachycephaly, prominant forehead, hypertelorism, and exophthalmos. Occasional features include cleft palate, omphalocele, and cardiac and genitourinary anomalies. The radiographic features at mid-gestation are characteristic.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/104500">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_116061"><div><strong>Pyknodysostosis</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>116061</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0238402</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Pycnodysostosis is characterized by short-limbed short stature, typical facial appearance (convex nasal ridge and small jaw with obtuse mandibular angle), osteosclerosis with increased bone fragility, acroosteolysis of the distal phalanges, delayed closure of the cranial sutures, and dysplasia of the clavicle. In affected individuals, the facial features become more prominent with age, likely due to progressive acroosteolysis of the facial bones, but can usually be appreciated from early childhood, particularly the small jaw and convex nasal ridge. Additional features include dental and nail anomalies. Intelligence is typically normal with mild psychomotor difficulties reported in some individuals.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/116061">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_78649"><div><strong>Aspartylglucosaminuria</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>78649</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0268225</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Aspartylglucosaminuria is a lysosomal storage disorder characterized by developmental delay, intellectual disability, behavioral manifestations (hyperactivity in young children, anxiety and restlessness in adolescence, and apathy in adulthood), recurrent infections, musculoskeletal features, and characteristic craniofacial features (prominent supraorbital ridges, hypertelorism, periorbital fullness, short nose with broad nasal bridge, thick vermilion of the upper and lower lips, and macroglossia) that become more prominent with age. Additional neurologic manifestations can include seizures, poor balance and coordination, and progressive cerebral atrophy in adulthood. Macrocephaly is common. Musculoskeletal features include lordosis, scoliosis, and arthritis in adolescents and young adults; vertebral dysplasia and/or rib cage abnormalities; and progressive muscle wasting, joint contractures, bursitis, and osteoporosis in adulthood. Skin manifestations (facial seborrhea, rosacea, and angiofibromas), gastrointestinal manifestations, neutropenia, and thrombocytopenia occur in some individuals. The clinical manifestations of aspartylglucosaminuria worsen with age, and adults have progressive psychomotor decline.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/78649">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_235174"><div><strong>Cervical spondylosis</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>235174</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1384641</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Arthrosis, i.e., of degenerative joint disease, affecting the cervical vertebral column.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/235174">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_322238"><div><strong>Spondyloepiphyseal dysplasia, Reardon type</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>322238</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1833603</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Spondyloepiphyseal dysplasia, Reardon type is an extremely rare type of spondyloepiphyseal dysplasia (see this term) described in several members of a single family to date and characterized by short stature, vertebral and femoral abnormalities, cervical instability and neurologic manifestations secondary to anomalies of the odontoid process.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/322238">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_337064"><div><strong>Oto-palato-digital syndrome, type II</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>337064</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1844696</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">The X-linked otopalatodigital (X-OPD) spectrum disorders, characterized primarily by skeletal dysplasia, include the following: Otopalatodigital syndrome type 1 (OPD1). Otopalatodigital syndrome type 2 (OPD2). Frontometaphyseal dysplasia type 1 (FMD1). Melnick-Needles syndrome (MNS). Terminal osseous dysplasia with pigmentary skin defects (TODPD). In OPD1, most manifestations are present at birth; females can present with severity similar to affected males, although some have only mild manifestations. In OPD2, females are less severely affected than related affected males. Most males with OPD2 die during the first year of life, usually from thoracic hypoplasia resulting in pulmonary insufficiency. Males who live beyond the first year of life are usually developmentally delayed and require respiratory support and assistance with feeding. In FMD1, females are less severely affected than related affected males. Males do not experience a progressive skeletal dysplasia but may have joint contractures and hand and foot malformations. Progressive scoliosis is observed in both affected males and females. In MNS, wide phenotypic variability is observed; some individuals are diagnosed in adulthood, while others require respiratory support and have reduced longevity. MNS in males results in perinatal lethality in all recorded cases. TODPD, seen only in females, is characterized by a skeletal dysplasia that is most prominent in the digits, pigmentary defects of the skin, and recurrent digital fibromata.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/337064">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_1854940"><div><strong>Intellectual developmental disorder, x-linked, syndromic 37</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1854940</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C5935567</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">X-linked syndromic intellectual developmental disorder-37 (MRXS37) is a developmental disorder showing phenotypic variability and variable severity. Male mutation carriers tend to be more severely affected than female mutation carriers, some of whom may even be asymptomatic. In general, the disorder is characterized by global developmental delay with delayed walking, speech delay, impaired intellectual development that ranges from borderline low to moderate, and behavioral abnormalities, such as autism and sleeping difficulties. Many patients are able to attend mainstream schools with assistance and work under supervision. Additional more variable features include sensorineural hearing loss, ocular anomalies, feeding difficulties, dysmorphic facial features, inguinal and umbilical hernia, genitourinary defects, congenital heart defects, musculoskeletal anomalies, and endocrine dysfunction, such as hypogonadism or hyperparathyroidism (Shepherdson et al., 2024).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1854940">Condition Record</a></div></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_78649" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Aspartylglucosaminuria</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_235174" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Cervical spondylosis</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_3486" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Cleidocranial dysostosis</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1854940" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Intellectual developmental disorder, x-linked, syndromic 37</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_104500" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Larsen syndrome</a></div><div class="jig-moreless" data-jigconfig="class: 'moveDown', moreText: 'See full list (9)', lessText: 'Show less', nodeBefore: 0"><span id="clinMore">
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_337064" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Oto-palato-digital syndrome, type II</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_116061" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Pyknodysostosis</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_322238" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Spondyloepiphyseal dysplasia, Reardon type</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_52470" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Spondylolisthesis</a></div></span></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_105">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Professional_guidelines">Professional guidelines</h1><a sid="105" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">PubMed<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpPM"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/36526328">Spondylolysis and Isthmic Spondylolisthesis: A Guide to Diagnosis and Management.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Mohile NV,
|
||
Kuczmarski AS,
|
||
Lee D,
|
||
Warburton C,
|
||
Rakoczy K,
|
||
Butler AJ</span><br />
|
||
<span class="medgenPMjournal">J Am Board Fam Med</span>
|
||
2022 Dec 23;35(6):1204-1216.
|
||
Epub 2022 Dec 16
|
||
doi: 10.3122/jabfm.2022.220130R1.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36526328" target="_blank">36526328</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/35504566">Management of lumbar spondylolysis in the adolescent athlete: a review of over 200 cases.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Choi JH,
|
||
Ochoa JK,
|
||
Lubinus A,
|
||
Timon S,
|
||
Lee YP,
|
||
Bhatia NN</span><br />
|
||
<span class="medgenPMjournal">Spine J</span>
|
||
2022 Oct;22(10):1628-1633.
|
||
Epub 2022 Apr 30
|
||
doi: 10.1016/j.spinee.2022.04.011.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35504566" target="_blank">35504566</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/31232791">Artistic Gymnastics Injuries; Epidemiology, Evaluation, and Treatment.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Desai N,
|
||
Vance DD,
|
||
Rosenwasser MP,
|
||
Ahmad CS</span><br />
|
||
<span class="medgenPMjournal">J Am Acad Orthop Surg</span>
|
||
2019 Jul 1;27(13):459-467.
|
||
doi: 10.5435/JAAOS-D-18-00147.
|
||
<span class="bold">PMID: </span><a href="/pubmed/31232791" target="_blank">31232791</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(%22spondylolysis%22%5Btiab%3A~0%5D)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">See all (77)</a></div></div>
|
||
</div>
|
||
<div class="display-none help-popup" id="guidelinesHelpPM">These guidelines are articles in PubMed that match specific search criteria developed by MedGen to capture the most relevant practice guidelines. This list may not be comprehensive and may include broader topics as well. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div><div class="display-none help-popup" id="guidelinesHelpCurated">These guidelines are manually curated by the MedGen team
|
||
to supplement articles available in PubMed. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div>
|
||
<div class="portlet mgSection" id="ID_103">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_clinical_studies">Recent clinical studies</h1><a sid="103" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">Etiology</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/36526328">Spondylolysis and Isthmic Spondylolisthesis: A Guide to Diagnosis and Management.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Mohile NV,
|
||
Kuczmarski AS,
|
||
Lee D,
|
||
Warburton C,
|
||
Rakoczy K,
|
||
Butler AJ</span><br />
|
||
<span class="medgenPMjournal">J Am Board Fam Med</span>
|
||
2022 Dec 23;35(6):1204-1216.
|
||
Epub 2022 Dec 16
|
||
doi: 10.3122/jabfm.2022.220130R1.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36526328" target="_blank">36526328</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/35504566">Management of lumbar spondylolysis in the adolescent athlete: a review of over 200 cases.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Choi JH,
|
||
Ochoa JK,
|
||
Lubinus A,
|
||
Timon S,
|
||
Lee YP,
|
||
Bhatia NN</span><br />
|
||
<span class="medgenPMjournal">Spine J</span>
|
||
2022 Oct;22(10):1628-1633.
|
||
Epub 2022 Apr 30
|
||
doi: 10.1016/j.spinee.2022.04.011.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35504566" target="_blank">35504566</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/34051941">Lumbosacral Spondylolysis and Spondylolisthesis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Chung CC,
|
||
Shimer AL</span><br />
|
||
<span class="medgenPMjournal">Clin Sports Med</span>
|
||
2021 Jul;40(3):471-490.
|
||
doi: 10.1016/j.csm.2021.03.004.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34051941" target="_blank">34051941</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/12890435">A systematic review of physiotherapy for spondylolysis and spondylolisthesis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">McNeely ML,
|
||
Torrance G,
|
||
Magee DJ</span><br />
|
||
<span class="medgenPMjournal">Man Ther</span>
|
||
2003 May;8(2):80-91.
|
||
doi: 10.1016/s1356-689x(02)00066-8.
|
||
<span class="bold">PMID: </span><a href="/pubmed/12890435" target="_blank">12890435</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/8451998">Spondylolysis and spondylolisthesis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Saraste H</span><br />
|
||
<span class="medgenPMjournal">Acta Orthop Scand Suppl</span>
|
||
1993;251:84-6.
|
||
doi: 10.3109/17453679309160129.
|
||
<span class="bold">PMID: </span><a href="/pubmed/8451998" target="_blank">8451998</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Spondylolysis%22%20AND%20Etiology%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (642)</a></div><h3 class="subhead">Diagnosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/36526328">Spondylolysis and Isthmic Spondylolisthesis: A Guide to Diagnosis and Management.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Mohile NV,
|
||
Kuczmarski AS,
|
||
Lee D,
|
||
Warburton C,
|
||
Rakoczy K,
|
||
Butler AJ</span><br />
|
||
<span class="medgenPMjournal">J Am Board Fam Med</span>
|
||
2022 Dec 23;35(6):1204-1216.
|
||
Epub 2022 Dec 16
|
||
doi: 10.3122/jabfm.2022.220130R1.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36526328" target="_blank">36526328</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/34051941">Lumbosacral Spondylolysis and Spondylolisthesis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Chung CC,
|
||
Shimer AL</span><br />
|
||
<span class="medgenPMjournal">Clin Sports Med</span>
|
||
2021 Jul;40(3):471-490.
|
||
doi: 10.1016/j.csm.2021.03.004.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34051941" target="_blank">34051941</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/32014131">Back Injuries.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Daniels JM,
|
||
Arguelles C,
|
||
Gleason C,
|
||
Dixon WH</span><br />
|
||
<span class="medgenPMjournal">Prim Care</span>
|
||
2020 Mar;47(1):147-164.
|
||
Epub 2019 Oct 17
|
||
doi: 10.1016/j.pop.2019.10.008.
|
||
<span class="bold">PMID: </span><a href="/pubmed/32014131" target="_blank">32014131</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/31232791">Artistic Gymnastics Injuries; Epidemiology, Evaluation, and Treatment.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Desai N,
|
||
Vance DD,
|
||
Rosenwasser MP,
|
||
Ahmad CS</span><br />
|
||
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<div class="nl"><a target="_blank" href="/pubmed/18326106">Spondylolisthesis and spondylolysis.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Hu SS,
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<div class="nl"><a target="_blank" href="/pubmed/36245007">Facets of facet joint interventions.</a></div>
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Jarvik JG,
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<div class="nl"><a target="_blank" href="/pubmed/12890435">A systematic review of physiotherapy for spondylolysis and spondylolisthesis.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">McNeely ML,
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Torrance G,
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<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Spondylolysis%22%20AND%20Therapy%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (193)</a></div><h3 class="subhead">Prognosis</h3>
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<div class="nl"><a target="_blank" href="/pubmed/36245007">Facets of facet joint interventions.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Said N,
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Amrhein TJ,
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Joshi AB,
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N NCN,
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Kranz PG</span><br />
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<span class="medgenPMjournal">Skeletal Radiol</span>
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2023 Oct;52(10):1873-1886.
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Epub 2022 Oct 17
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doi: 10.1007/s00256-022-04184-5.
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<span class="bold">PMID: </span><a href="/pubmed/36245007" target="_blank">36245007</a></div>
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<div class="nl"><a target="_blank" href="/pubmed/36526328">Spondylolysis and Isthmic Spondylolisthesis: A Guide to Diagnosis and Management.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Mohile NV,
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Kuczmarski AS,
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Lee D,
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Warburton C,
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<div class="nl"><a target="_blank" href="/pubmed/28574940">Management of Lumbar Conditions in the Elite Athlete.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Hsu WK,
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<div class="nl"><a target="_blank" href="/pubmed/18399601">Spondylolisthesis and spondylolysis.</a></div>
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Tribus CB,
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<div class="portlet_content ln"><span class="medgenPMauthor">Hosea TM,
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<div class="nl"><a target="_blank" href="/pubmed/38027141">Total body bone mineral density and various spinal disorders: a Mendelian randomization study.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Jiang Q,
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Gao H,
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Shi X,
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Wu Y,
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Ni W,
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||
|
||
<div class="nl"><a target="_blank" href="/pubmed/36245007">Facets of facet joint interventions.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Said N,
|
||
Amrhein TJ,
|
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Joshi AB,
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N NCN,
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Kranz PG</span><br />
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<span class="medgenPMjournal">Skeletal Radiol</span>
|
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2023 Oct;52(10):1873-1886.
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Epub 2022 Oct 17
|
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doi: 10.1007/s00256-022-04184-5.
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||
<span class="bold">PMID: </span><a href="/pubmed/36245007" target="_blank">36245007</a></div>
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<div class="nl"><a target="_blank" href="/pubmed/35504566">Management of lumbar spondylolysis in the adolescent athlete: a review of over 200 cases.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Choi JH,
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Ochoa JK,
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Lubinus A,
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<span class="bold">PMID: </span><a href="/pubmed/35504566" target="_blank">35504566</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Cook RW,
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<div class="nl"><a target="_blank" href="/pubmed/6346204">The pathophysiology of degenerative disease of the lumbar spine.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Yong-Hing K,
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|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_104">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_systematic_reviews">Recent systematic reviews</h1><a sid="104" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln">
|
||
<div class="nl"><a target="_blank" href="/pubmed/36150752">Incidence, prevalence and risk factors for low back pain in adolescent athletes: a systematic review and meta-analysis.</a></div>
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||
<div class="portlet_content ln"><span class="medgenPMauthor">Wall J,
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Meehan WP 3rd,
|
||
Trompeter K,
|
||
Gissane C,
|
||
Mockler D,
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||
van Dyk N,
|
||
Wilson F</span><br />
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<span class="medgenPMjournal">Br J Sports Med</span>
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||
2022 Nov;56(22):1299-1306.
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||
Epub 2022 Sep 23
|
||
doi: 10.1136/bjsports-2021-104749.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36150752" target="_blank">36150752</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/27669047">Imaging Pediatric Spondylolysis: A Systematic Review.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Tofte JN,
|
||
CarlLee TL,
|
||
Holte AJ,
|
||
Sitton SE,
|
||
Weinstein SL</span><br />
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||
<span class="medgenPMjournal">Spine (Phila Pa 1976)</span>
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||
2017 May 15;42(10):777-782.
|
||
doi: 10.1097/BRS.0000000000001912.
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||
<span class="bold">PMID: </span><a href="/pubmed/27669047" target="_blank">27669047</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/26359154">MRI Findings of Disc Degeneration are More Prevalent in Adults with Low Back Pain than in Asymptomatic Controls: A Systematic Review and Meta-Analysis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Brinjikji W,
|
||
Diehn FE,
|
||
Jarvik JG,
|
||
Carr CM,
|
||
Kallmes DF,
|
||
Murad MH,
|
||
Luetmer PH</span><br />
|
||
<span class="medgenPMjournal">AJNR Am J Neuroradiol</span>
|
||
2015 Dec;36(12):2394-9.
|
||
Epub 2015 Sep 10
|
||
doi: 10.3174/ajnr.A4498.
|
||
<span class="bold">PMID: </span><a href="/pubmed/26359154" target="_blank">26359154</a><a href="/pmc/articles/PMC7964277" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/22668574">Functional outcome following direct repair or intervertebral fusion for adolescent spondylolysis: a systematic review.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Westacott DJ,
|
||
Cooke SJ</span><br />
|
||
<span class="medgenPMjournal">J Pediatr Orthop B</span>
|
||
2012 Nov;21(6):596-601.
|
||
doi: 10.1097/BPB.0b013e328355393d.
|
||
<span class="bold">PMID: </span><a href="/pubmed/22668574" target="_blank">22668574</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/12890435">A systematic review of physiotherapy for spondylolysis and spondylolisthesis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">McNeely ML,
|
||
Torrance G,
|
||
Magee DJ</span><br />
|
||
<span class="medgenPMjournal">Man Ther</span>
|
||
2003 May;8(2):80-91.
|
||
doi: 10.1016/s1356-689x(02)00066-8.
|
||
<span class="bold">PMID: </span><a href="/pubmed/12890435" target="_blank">12890435</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Spondylolysis%22%20AND%20systematic%5Bsb%5D%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (33)</a></div></div>
|
||
</div>
|
||
</div></div></div></div></div></div></div>
|
||
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|
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|
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|
||
<div class="supplemental col three_col last">
|
||
<h2 class="offscreen_noflow">Supplemental Content</h2>
|
||
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<div>
|
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|
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<div class="portlet mgSection" id="ID_113">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Table_of_contents">Table of contents</h1><a sid="113" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Clinical_resources">Clinical resources</h1><a sid="119" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="portlet_content ln"><ul><li><a href="https://clinicaltrials.gov/search?cond=Spondylolysis" target="_blank">ClinicalTrials.gov</a></li></ul></div>
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|
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<div class="portlet mgSection" id="ID_121">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Practice_guidelines">Practice guidelines</h1><a sid="121" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="portlet_content ln"><ul class="a_poppers"><li><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(%22spondylolysis%22%5Btiab%3A~0%5D)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">PubMed</a><div class="help-popup">See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div></li><li><a target="_blank" href="/books/?term=((%22clinical%20guidelines%22%5BResource%20Type%5D)%20OR%20%22practice%20guideline%22%5BPublication%20Type%5D)%20AND%20(%22Spondylolysis%22)">Bookshelf</a><div class="help-popup">See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div></li></ul></div>
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