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<meta name="keywords" content="C4476767, diffuse alveolar haemorrhage, diffuse alveolar haemorrhage (disease), diffuse alveolar hemorrhage, diffuse alveolar hemorrhage (disease), diffuse hemorrhage of pulmonary alveolar, pathologic function, autosomal dominant, autosomal recessive, birth defects, chromosomal disease, chromosome, clinical features, clinical findings, clinical genetics, clinical recommendations, clinvar, congenital chromosomal disease, consumer genetic resources, cytogenetic location, disease characteristics, disease definitions, disease descriptions, disease ontology, disease synonyms, disease vocabulary, dysmorphology, entrez, familial disease, gene, gene-disease relationship, genereviews, genetic disease, genetic disorder, genetic terminology, genetic testing registry, genetics home reference, genomic disease, gtr, hereditary disease, heritable disease, hpo, human phenotype ontology, inherited disease, management guidelines, maternal inheritance, medgen, medical genetics, medical subject headings, mesh, mitochondrial inheritance, mode of inheritance, national center for biotechnology information, national institutes of health, national library of medicine, ncbi, nih, nlm, omim, ordo, orphanet, paternal inheritance, phenome, position statements, professional practice guidelines, rare disease, reference sequence, refseq, snomed ct, syndrome, undiagnosed diseases, x-linked recessive" /><meta name="description" content="A type of of pulmonary hemorrhage that originates from the pulmonary microcirculation, including the alveolar capillaries, arterioles, and venules. It presents with hemoptysis, anemia, diffuse lung infiltration, and acute respiratory failure. The diagnosis is confirmed by the observation of the accumulation of red blood cells, fibrin, or hemosiderin-laden macrophage in the alveolar space on pathologic biopsy. Hemosiderin, a product of hemoglobin degradation, appears at least 48-72 hours after bleeding and is helpful in distinguishing diffuse alveolar hemorrhage from surgical trauma. Mild interstitial thickening, organizing pneumonia, or diffuse alveolar damage can also be seen." /><meta name="robots" content="index,nofollow,noarchive" />
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<!--
UID=1381751
ConceptID=C4476767
-->
<!--imgCountBooks = 0--><h1 class="medgenTitle"><div class="MedGenTitleText">Diffuse alveolar hemorrhage</div></h1><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1381751</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C4476767</a></dd><dt><span class="dotprefix"></span></dt><dd>Pathologic Function</dd></dl></div></div><table class="medgenTable"><tbody><tr><td>Synonyms:</td>
<td>Diffuse alveolar haemorrhage; diffuse alveolar haemorrhage (disease); diffuse alveolar hemorrhage; diffuse alveolar hemorrhage (disease); Diffuse hemorrhage of pulmonary alveolar</td></tr>
<tr><td><span class="bold">SNOMED CT: </span></td>
<td>Diffuse alveolar hemorrhage (829972004); Diffuse hemorrhage of pulmonary alveolar (829972004)</td></tr>
<tr><td>Modes of inheritance:</td>
<td>
<div class="divPopper rprt" id="moi_988794"><div><strong>Not genetically inherited</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>988794</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier assigned by MedGen (starting with CN) for terms&#10;that cannot be identified in NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">CN307044</a></dd><dt><span class="dotprefix"></span></dt><dd>Finding</dd></dl></div></div></div>
<div class="spaceAbove">Source: Orphanet</div>
<div class="spaceAbove">clinical entity without genetic inheritance.</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/988794">This record</a></div></div>
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#moi_988794" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Not genetically inherited</a><span> (Orphanet)</span></div></td></tr>
<tr><td colspan="2" class="small"> </td></tr><tr><td>HPO:</td>
<td><a target="_blank" title="Human Phenotype Ontology" href="https://hpo.jax.org/app/browse/term/HP:0025420">HP:0025420</a></td></tr>
<tr><td>Monarch Initiative:</td>
<td><a href="https://monarchinitiative.org/disease/MONDO:0019540" target="_blank">MONDO:0019540</a></td></tr>
<tr><td>Orphanet:</td>
<td><a target="_blank" title="Orphanet: The portal for rare diseases and orphan drugs" href="http://www.orpha.net/consor/cgi-bin/OC_Exp.php?lng=EN&amp;Expert=90060">ORPHA90060</a></td></tr></tbody></table></div><div class="rprt-body jig-ncbiinpagenav" data-jigconfig="smoothScroll: false, gotoTopLink: true, gotoTopLinkText: '', gotoTopLinkAttrs: {'title': 'Go to the top of the page'},allHeadingLevels: ['h1'], topOfPageTOC: true, tocId: 'my-toc'"><div id="rprt-tabs-1" class="rprt-tab"><div id="tb-termsProp-1"><div class="leftCol mgCol"><div>
<div class="portlet mgSection" id="ID_100">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Definition">Definition</h1><a sid="100" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln">A type of of pulmonary hemorrhage that originates from the pulmonary microcirculation, including the alveolar capillaries, arterioles, and venules. It presents with hemoptysis, anemia, diffuse lung infiltration, and acute respiratory failure. The diagnosis is confirmed by the observation of the accumulation of red blood cells, fibrin, or hemosiderin-laden macrophage in the alveolar space on pathologic biopsy. Hemosiderin, a product of hemoglobin degradation, appears at least 48-72 hours after bleeding and is helpful in distinguishing diffuse alveolar hemorrhage from surgical trauma. Mild interstitial thickening, organizing pneumonia, or diffuse alveolar damage can also be seen. [from <a title="Human Phenotype Ontology" href="http://www.human-phenotype-ontology.org" class="defSource" target="_blank">HPO</a>]</div>
</div>
<div class="portlet mgSection" id="ID_118">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Term_Hierarchy">Term Hierarchy</h1><a sid="118" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln HierarchyGTR"><div class="jig-ncbitabs"><ul><li><a href="#tabGTR">GTR</a></li><li><a href="#tabMGEN">MeSH</a></li></ul><div id="tabGTR"><div class="search_result"><div class="rprts"><div class="chiclet_legend"><span class="chiclet_list" style="position:static;"><span title="Clinical test" class="chiclet Ccolor round">C</span><span>Clinical test,  </span><span title="Research test" class="chiclet Rcolor round">R</span><span>Research test,  </span><span title="OMIM" class="chiclet Ocolor ">O</span><span>OMIM,  </span><span title="GeneReview" class="chiclet Gcolor">G</span><span><em>GeneReviews</em>,  </span><span title="ClinVar" class="chiclet Vcolor">V</span><span>ClinVar  </span></span></div><div id="hierarchy" class="margin_t1"><div class="ds_tree"><ul><li class="matched_ds"><span class="chiclet_list"><span class="chiclet unavailable round" title="Clinical test">C</span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet unavailable" title="OMIM">O</span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet unavailable" title="ClinVar">V</span></span><span class="TLline">Diffuse alveolar hemorrhage</span></li></ul></div></div></div></div></div><div id="tabMGEN"><div class="ds_tree"><ul><li><span class="TLline"><a href="/medgen/19750" ref="tree=MeSH" title="MedGen record for Disease, Respiratory Tract">Disease, Respiratory Tract</a></span><ul><li><span class="TLline"><a href="/medgen/7399" ref="tree=MeSH" title="MedGen record for Disorder of lung">Disorder of lung</a></span><ul><li><span class="matched_ds">Diffuse alveolar hemorrhage</span></li></ul></li></ul></li></ul></div></div></div></div>
</div>
<div class="portlet mgSection" id="ID_112">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Conditions_with_this_feature">Conditions with this feature</h1><a sid="112" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln clinfeat">
<div class="divPopper rprt" id="rdis_82790"><div><strong>Ehlers-Danlos syndrome, type 4</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>82790</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C0268338</a></dd><dt><span class="dotprefix"></span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
<div class="spaceAbove">Vascular Ehlers-Danlos syndrome (vEDS) is characterized by arterial, intestinal, and/or uterine fragility; thin, translucent skin; easy bruising; characteristic facial appearance (thin vermilion of the lips, micrognathia, narrow nose, prominent eyes); and an aged appearance to the extremities, particularly the hands. Vascular dissection or rupture, gastrointestinal perforation, or organ rupture are the presenting signs in most adults with vEDS. Arterial rupture may be preceded by aneurysm, arteriovenous fistulae, or dissection but also may occur spontaneously. The majority (60%) of individuals with vEDS who are diagnosed before age 18 years are identified because of a positive family history. Neonates may present with clubfoot, hip dislocation, limb deficiency, and/or amniotic bands. Approximately half of children tested for vEDS in the absence of a positive family history present with a major complication at an average age of 11 years. Four minor diagnostic features distal joint hypermobility, easy bruising, thin skin, and clubfeet are most often present in those children ascertained without a major complication.</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/82790">Condition Record</a></div></div>
<div class="divPopper rprt" id="rdis_333882"><div><strong>Heme oxygenase 1 deficiency</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>333882</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C1841651</a></dd><dt><span class="dotprefix"></span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
<div class="spaceAbove">Heme oxygenase-1 deficiency (HMOX1D) is a rare autosomal recessive disorder with a complex clinical presentation including direct antibody negative hemolytic anemia, low bilirubin, and hyperinflammation (summary by Chau et al., 2020). Other features may include asplenia and nephritis (Radhakrishnan et al., 2011).</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/333882">Condition Record</a></div></div>
<div class="divPopper rprt" id="rdis_811223"><div><strong>Granulomatosis with polyangiitis</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>811223</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C3495801</a></dd><dt><span class="dotprefix"></span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
<div class="spaceAbove">Granulomatosis with polyangiitis, formerly termed Wegener granulomatosis, is a systemic disease with a complex genetic background. It is characterized by necrotizing granulomatous inflammation of the upper and lower respiratory tract, glomerulonephritis, vasculitis, and the presence of antineutrophil cytoplasmatic autoantibodies (ANCAs) in patient sera. These ANCAs are antibodies to a defined target antigen, proteinase-3 (PR3, PRTN3; 177020), which is present within primary azurophil granules of neutrophils (PMNs) and lysozymes of monocytes. On cytokine priming of PMNs, PR3 translocates to the cell surface, where PR3-ANCAs can interact with their antigens and activate PMNs. PMNs from patients with active GPA express PR3 on their surface, produce respiratory burst, and release proteolytic enzymes after activation with PR3-ANCAs. The consequence is a self-sustaining inflammatory process (Jagiello et al., 2004).</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/811223">Condition Record</a></div></div>
<div class="divPopper rprt" id="rdis_863504"><div><strong>Periodic fever-infantile enterocolitis-autoinflammatory syndrome</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>863504</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C4015067</a></dd><dt><span class="dotprefix"></span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
<div class="spaceAbove">Autoinflammation with infantile enterocolitis is an autosomal dominant disorder characterized by onset of recurrent flares of autoinflammation in early infancy. Affected individuals tend to have poor overall growth and gastrointestinal symptoms in infancy associated with laboratory evidence of activated inflammation. This initial presentation is followed by recurrent febrile episodes with splenomegaly and sometimes hematologic disturbances, arthralgias, or myalgias. The disorder results from overactivation of an arm of the immune response system (Romberg et al., 2014; Canna et al., 2014).</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/863504">Condition Record</a></div></div>
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_82790" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Ehlers-Danlos syndrome, type 4</a></div>
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_811223" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Granulomatosis with polyangiitis</a></div>
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_333882" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Heme oxygenase 1 deficiency</a></div>
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_863504" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Periodic fever-infantile enterocolitis-autoinflammatory syndrome</a></div></div>
</div>
<div class="portlet mgSection" id="ID_105">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Professional_guidelines">Professional guidelines</h1><a sid="105" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln"><h3 class="subhead">PubMed<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpPM"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3>
<div class="nl"><a target="_blank" href="/pubmed/33466873">Treatment of Diffuse Alveolar Hemorrhage: Controlling Inflammation and Obtaining Rapid and Effective Hemostasis.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Park JA</span><br />
<span class="medgenPMjournal">Int J Mol Sci</span>
2021 Jan 14;22(2)
doi: 10.3390/ijms22020793.
<span class="bold">PMID: </span><a href="/pubmed/33466873" target="_blank">33466873</a><a href="/pmc/articles/PMC7830514" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/32324122">Epidemiology and management of interstitial lung disease in ANCA-associated vasculitis.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Sebastiani M,
Manfredi A,
Vacchi C,
Cassone G,
Faverio P,
Cavazza A,
Sverzellati N,
Salvarani C,
Luppi F</span><br />
<span class="medgenPMjournal">Clin Exp Rheumatol</span>
2020 Mar-Apr;38 Suppl 124(2):221-231.
Epub 2020 Apr 22
<span class="bold">PMID: </span><a href="/pubmed/32324122" target="_blank">32324122</a></div>
<div class="nl"><a target="_blank" href="/pubmed/32036761">Systemic lupus erythematosus and diffuse alveolar hemorrhage, etiology and novel treatment strategies.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Al-Adhoubi NK,
Bystrom J</span><br />
<span class="medgenPMjournal">Lupus</span>
2020 Apr;29(4):355-363.
Epub 2020 Feb 9
doi: 10.1177/0961203320903798.
<span class="bold">PMID: </span><a href="/pubmed/32036761" target="_blank">32036761</a><a href="/pmc/articles/PMC7436451" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(%22diffuse%20alveolar%20hemorrhage%22%5Btiab%3A~0%5D)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">See all (22)</a></div></div>
</div>
<div class="display-none help-popup" id="guidelinesHelpPM">These guidelines are articles in PubMed that match specific search criteria developed by MedGen to capture the most relevant practice guidelines. This list may not be comprehensive and may include broader topics as well. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div><div class="display-none help-popup" id="guidelinesHelpCurated">These guidelines are manually curated by the MedGen team
to supplement articles available in PubMed. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div>
<div class="portlet mgSection" id="ID_103">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_clinical_studies">Recent clinical studies</h1><a sid="103" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln"><h3 class="subhead">Etiology</h3>
<div class="nl"><a target="_blank" href="/pubmed/33466873">Treatment of Diffuse Alveolar Hemorrhage: Controlling Inflammation and Obtaining Rapid and Effective Hemostasis.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Park JA</span><br />
<span class="medgenPMjournal">Int J Mol Sci</span>
2021 Jan 14;22(2)
doi: 10.3390/ijms22020793.
<span class="bold">PMID: </span><a href="/pubmed/33466873" target="_blank">33466873</a><a href="/pmc/articles/PMC7830514" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/33246295">Idiopathic pulmonary hemosiderosis: A state of the art review.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Saha BK</span><br />
<span class="medgenPMjournal">Respir Med</span>
2021 Jan;176:106234.
Epub 2020 Nov 17
doi: 10.1016/j.rmed.2020.106234.
<span class="bold">PMID: </span><a href="/pubmed/33246295" target="_blank">33246295</a></div>
<div class="nl"><a target="_blank" href="/pubmed/32476936">Diffuse alveolar hemorrhage: how relevant is etiology?</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Alexandre AT,
Vale A,
Gomes T</span><br />
<span class="medgenPMjournal">Sarcoidosis Vasc Diffuse Lung Dis</span>
2019;36(1):47-52.
Epub 2019 May 1
doi: 10.36141/svdld.v36i1.7160.
<span class="bold">PMID: </span><a href="/pubmed/32476936" target="_blank">32476936</a><a href="/pmc/articles/PMC7247111" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/28675998">Cardiovascular and Pulmonary Manifestations of Systemic Lupus Erythematosus.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Tselios K,
Urowitz MB</span><br />
<span class="medgenPMjournal">Curr Rheumatol Rev</span>
2017;13(3):206-218.
doi: 10.2174/1573397113666170704102444.
<span class="bold">PMID: </span><a href="/pubmed/28675998" target="_blank">28675998</a></div>
<div class="nl"><a target="_blank" href="/pubmed/28397125">Diffuse Alveolar Hemorrhage in Autoimmune Diseases.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Martínez-Martínez MU,
Oostdam DAH,
Abud-Mendoza C</span><br />
<span class="medgenPMjournal">Curr Rheumatol Rep</span>
2017 May;19(5):27.
doi: 10.1007/s11926-017-0651-y.
<span class="bold">PMID: </span><a href="/pubmed/28397125" target="_blank">28397125</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Diffuse%20alveolar%20hemorrhage%22%20AND%20Etiology%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (234)</a></div><h3 class="subhead">Diagnosis</h3>
<div class="nl"><a target="_blank" href="/pubmed/33466873">Treatment of Diffuse Alveolar Hemorrhage: Controlling Inflammation and Obtaining Rapid and Effective Hemostasis.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Park JA</span><br />
<span class="medgenPMjournal">Int J Mol Sci</span>
2021 Jan 14;22(2)
doi: 10.3390/ijms22020793.
<span class="bold">PMID: </span><a href="/pubmed/33466873" target="_blank">33466873</a><a href="/pmc/articles/PMC7830514" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/32036761">Systemic lupus erythematosus and diffuse alveolar hemorrhage, etiology and novel treatment strategies.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Al-Adhoubi NK,
Bystrom J</span><br />
<span class="medgenPMjournal">Lupus</span>
2020 Apr;29(4):355-363.
Epub 2020 Feb 9
doi: 10.1177/0961203320903798.
<span class="bold">PMID: </span><a href="/pubmed/32036761" target="_blank">32036761</a><a href="/pmc/articles/PMC7436451" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/28397125">Diffuse Alveolar Hemorrhage in Autoimmune Diseases.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Martínez-Martínez MU,
Oostdam DAH,
Abud-Mendoza C</span><br />
<span class="medgenPMjournal">Curr Rheumatol Rep</span>
2017 May;19(5):27.
doi: 10.1007/s11926-017-0651-y.
<span class="bold">PMID: </span><a href="/pubmed/28397125" target="_blank">28397125</a></div>
<div class="nl"><a target="_blank" href="/pubmed/25836645">Pulmonary vasculitis.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Lally L,
Spiera RF</span><br />
<span class="medgenPMjournal">Rheum Dis Clin North Am</span>
2015 May;41(2):315-31.
Epub 2015 Feb 27
doi: 10.1016/j.rdc.2015.01.004.
<span class="bold">PMID: </span><a href="/pubmed/25836645" target="_blank">25836645</a></div>
<div class="nl"><a target="_blank" href="/pubmed/20442117">Diffuse alveolar hemorrhage.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Lara AR,
Schwarz MI</span><br />
<span class="medgenPMjournal">Chest</span>
2010 May;137(5):1164-71.
doi: 10.1378/chest.08-2084.
<span class="bold">PMID: </span><a href="/pubmed/20442117" target="_blank">20442117</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Diffuse%20alveolar%20hemorrhage%22%20AND%20Diagnosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (420)</a></div><h3 class="subhead">Therapy</h3>
<div class="nl"><a target="_blank" href="/pubmed/37080799">Alectinib-Induced Diffuse Alveolar Hemorrhage.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Fukuda Y,
Sagara H</span><br />
<span class="medgenPMjournal">Arch Bronconeumol</span>
2023 Jun;59(6):396.
Epub 2023 Mar 21
doi: 10.1016/j.arbres.2023.03.013.
<span class="bold">PMID: </span><a href="/pubmed/37080799" target="_blank">37080799</a></div>
<div class="nl"><a target="_blank" href="/pubmed/33466873">Treatment of Diffuse Alveolar Hemorrhage: Controlling Inflammation and Obtaining Rapid and Effective Hemostasis.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Park JA</span><br />
<span class="medgenPMjournal">Int J Mol Sci</span>
2021 Jan 14;22(2)
doi: 10.3390/ijms22020793.
<span class="bold">PMID: </span><a href="/pubmed/33466873" target="_blank">33466873</a><a href="/pmc/articles/PMC7830514" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/32036761">Systemic lupus erythematosus and diffuse alveolar hemorrhage, etiology and novel treatment strategies.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Al-Adhoubi NK,
Bystrom J</span><br />
<span class="medgenPMjournal">Lupus</span>
2020 Apr;29(4):355-363.
Epub 2020 Feb 9
doi: 10.1177/0961203320903798.
<span class="bold">PMID: </span><a href="/pubmed/32036761" target="_blank">32036761</a><a href="/pmc/articles/PMC7436451" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/31567139">Dabigatran-Associated Diffuse Alveolar Hemorrhage.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Shankar S,
Saxena A,
Saverimuthu A,
Perez A,
Chandar P,
Shenoy MA,
Seneviratne C,
Kupfer Y</span><br />
<span class="medgenPMjournal">Am J Ther</span>
2020 May/Jun;27(3):e301-e303.
doi: 10.1097/MJT.0000000000000816.
<span class="bold">PMID: </span><a href="/pubmed/31567139" target="_blank">31567139</a></div>
<div class="nl"><a target="_blank" href="/pubmed/20442117">Diffuse alveolar hemorrhage.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Lara AR,
Schwarz MI</span><br />
<span class="medgenPMjournal">Chest</span>
2010 May;137(5):1164-71.
doi: 10.1378/chest.08-2084.
<span class="bold">PMID: </span><a href="/pubmed/20442117" target="_blank">20442117</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Diffuse%20alveolar%20hemorrhage%22%20AND%20Therapy%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (368)</a></div><h3 class="subhead">Prognosis</h3>
<div class="nl"><a target="_blank" href="/pubmed/38547915">Systemic Lupus Erythematosus-related Lung Disease.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Bendstrup E,
Lynn E,
Troldborg A</span><br />
<span class="medgenPMjournal">Semin Respir Crit Care Med</span>
2024 Jun;45(3):386-396.
Epub 2024 Mar 28
doi: 10.1055/s-0044-1782653.
<span class="bold">PMID: </span><a href="/pubmed/38547915" target="_blank">38547915</a></div>
<div class="nl"><a target="_blank" href="/pubmed/33246295">Idiopathic pulmonary hemosiderosis: A state of the art review.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Saha BK</span><br />
<span class="medgenPMjournal">Respir Med</span>
2021 Jan;176:106234.
Epub 2020 Nov 17
doi: 10.1016/j.rmed.2020.106234.
<span class="bold">PMID: </span><a href="/pubmed/33246295" target="_blank">33246295</a></div>
<div class="nl"><a target="_blank" href="/pubmed/31137062">Pulmonary Complications of Systemic Lupus Erythematosus.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Hannah JR,
D'Cruz DP</span><br />
<span class="medgenPMjournal">Semin Respir Crit Care Med</span>
2019 Apr;40(2):227-234.
Epub 2019 May 28
doi: 10.1055/s-0039-1685537.
<span class="bold">PMID: </span><a href="/pubmed/31137062" target="_blank">31137062</a></div>
<div class="nl"><a target="_blank" href="/pubmed/28675998">Cardiovascular and Pulmonary Manifestations of Systemic Lupus Erythematosus.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Tselios K,
Urowitz MB</span><br />
<span class="medgenPMjournal">Curr Rheumatol Rev</span>
2017;13(3):206-218.
doi: 10.2174/1573397113666170704102444.
<span class="bold">PMID: </span><a href="/pubmed/28675998" target="_blank">28675998</a></div>
<div class="nl"><a target="_blank" href="/pubmed/28397125">Diffuse Alveolar Hemorrhage in Autoimmune Diseases.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Martínez-Martínez MU,
Oostdam DAH,
Abud-Mendoza C</span><br />
<span class="medgenPMjournal">Curr Rheumatol Rep</span>
2017 May;19(5):27.
doi: 10.1007/s11926-017-0651-y.
<span class="bold">PMID: </span><a href="/pubmed/28397125" target="_blank">28397125</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Diffuse%20alveolar%20hemorrhage%22%20AND%20Prognosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (229)</a></div><h3 class="subhead">Clinical prediction guides</h3>
<div class="nl"><a target="_blank" href="/pubmed/33246295">Idiopathic pulmonary hemosiderosis: A state of the art review.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Saha BK</span><br />
<span class="medgenPMjournal">Respir Med</span>
2021 Jan;176:106234.
Epub 2020 Nov 17
doi: 10.1016/j.rmed.2020.106234.
<span class="bold">PMID: </span><a href="/pubmed/33246295" target="_blank">33246295</a></div>
<div class="nl"><a target="_blank" href="/pubmed/32324122">Epidemiology and management of interstitial lung disease in ANCA-associated vasculitis.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Sebastiani M,
Manfredi A,
Vacchi C,
Cassone G,
Faverio P,
Cavazza A,
Sverzellati N,
Salvarani C,
Luppi F</span><br />
<span class="medgenPMjournal">Clin Exp Rheumatol</span>
2020 Mar-Apr;38 Suppl 124(2):221-231.
Epub 2020 Apr 22
<span class="bold">PMID: </span><a href="/pubmed/32324122" target="_blank">32324122</a></div>
<div class="nl"><a target="_blank" href="/pubmed/32476936">Diffuse alveolar hemorrhage: how relevant is etiology?</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Alexandre AT,
Vale A,
Gomes T</span><br />
<span class="medgenPMjournal">Sarcoidosis Vasc Diffuse Lung Dis</span>
2019;36(1):47-52.
Epub 2019 May 1
doi: 10.36141/svdld.v36i1.7160.
<span class="bold">PMID: </span><a href="/pubmed/32476936" target="_blank">32476936</a><a href="/pmc/articles/PMC7247111" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/29128012">Noninfectious Acute Lung Injury Syndromes Early After Hematopoietic Stem Cell Transplantation.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Ahya VN</span><br />
<span class="medgenPMjournal">Clin Chest Med</span>
2017 Dec;38(4):595-606.
Epub 2017 Sep 19
doi: 10.1016/j.ccm.2017.07.002.
<span class="bold">PMID: </span><a href="/pubmed/29128012" target="_blank">29128012</a><a href="/pmc/articles/PMC7131710" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/25836645">Pulmonary vasculitis.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Lally L,
Spiera RF</span><br />
<span class="medgenPMjournal">Rheum Dis Clin North Am</span>
2015 May;41(2):315-31.
Epub 2015 Feb 27
doi: 10.1016/j.rdc.2015.01.004.
<span class="bold">PMID: </span><a href="/pubmed/25836645" target="_blank">25836645</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Diffuse%20alveolar%20hemorrhage%22%20AND%20Clinical%20prediction%20guides%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (117)</a></div></div>
</div>
<div class="portlet mgSection" id="ID_104">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_systematic_reviews">Recent systematic reviews</h1><a sid="104" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln">
<div class="nl"><a target="_blank" href="/pubmed/37722463">Clinical features, risk factors, and outcomes of diffuse alveolar hemorrhage in antiphospholipid syndrome: A mixed-method approach combining a multicenter cohort with a systematic literature review.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Figueroa-Parra G,
Meade-Aguilar JA,
Langenfeld HE,
González-Treviño M,
Hocaoglu M,
Hanson AC,
Prokop LJ,
Murad MH,
Cartin-Ceba R,
Specks U,
Majithia V,
Crowson CS,
Duarte-García A</span><br />
<span class="medgenPMjournal">Clin Immunol</span>
2023 Nov;256:109775.
Epub 2023 Sep 16
doi: 10.1016/j.clim.2023.109775.
<span class="bold">PMID: </span><a href="/pubmed/37722463" target="_blank">37722463</a></div>
<div class="nl"><a target="_blank" href="/pubmed/34618944">Management of diffuse alveolar hemorrhage in the hematopoietic stem cell transplantation population: A systematic review.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Loecher AM,
West K,
Quinn TD,
Defayette AA</span><br />
<span class="medgenPMjournal">Pharmacotherapy</span>
2021 Nov;41(11):943-952.
Epub 2021 Oct 20
doi: 10.1002/phar.2630.
<span class="bold">PMID: </span><a href="/pubmed/34618944" target="_blank">34618944</a></div>
<div class="nl"><a target="_blank" href="/pubmed/33593433">Risk factors for mortality of diffuse alveolar hemorrhage in systemic lupus erythematosus: a systematic review and meta-analysis.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Jiang M,
Chen R,
Zhao L,
Zhang X</span><br />
<span class="medgenPMjournal">Arthritis Res Ther</span>
2021 Feb 16;23(1):57.
doi: 10.1186/s13075-021-02435-9.
<span class="bold">PMID: </span><a href="/pubmed/33593433" target="_blank">33593433</a><a href="/pmc/articles/PMC7885396" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/33190331">Utilization of extracorporeal life support for diffuse alveolar damage and diffuse alveolar hemorrhage: A systematic review.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Reddy HG,
Maynes EJ,
Saxena A,
Austin MA,
O'Malley TJ,
Gadda MN,
Al-Rawas NN,
Baram M,
Awsare BK,
Massey HT,
Tchantchaleishvili V</span><br />
<span class="medgenPMjournal">Artif Organs</span>
2021 Jun;45(6):559-568.
Epub 2021 Jan 25
doi: 10.1111/aor.13861.
<span class="bold">PMID: </span><a href="/pubmed/33190331" target="_blank">33190331</a></div>
<div class="nl"><a target="_blank" href="/pubmed/26308350">Systematic Review of Diffuse Alveolar Hemorrhage in Systemic Lupus Erythematosus: Focus on Outcome and Therapy.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Ednalino C,
Yip J,
Carsons SE</span><br />
<span class="medgenPMjournal">J Clin Rheumatol</span>
2015 Sep;21(6):305-10.
doi: 10.1097/RHU.0000000000000291.
<span class="bold">PMID: </span><a href="/pubmed/26308350" target="_blank">26308350</a></div>
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