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<meta name="keywords" content="C0575170, cervical kyphosis, finding, kyphosis deformity of cervical spine, rounded neck, autosomal dominant, autosomal recessive, birth defects, chromosomal disease, chromosome, clinical features, clinical findings, clinical genetics, clinical recommendations, clinvar, congenital chromosomal disease, consumer genetic resources, cytogenetic location, disease characteristics, disease definitions, disease descriptions, disease ontology, disease synonyms, disease vocabulary, dysmorphology, entrez, familial disease, gene, gene-disease relationship, genereviews, genetic disease, genetic disorder, genetic terminology, genetic testing registry, genetics home reference, genomic disease, gtr, hereditary disease, heritable disease, hpo, human phenotype ontology, inherited disease, management guidelines, maternal inheritance, medgen, medical genetics, medical subject headings, mesh, mitochondrial inheritance, mode of inheritance, national center for biotechnology information, national institutes of health, national library of medicine, ncbi, nih, nlm, omim, ordo, orphanet, paternal inheritance, phenome, position statements, professional practice guidelines, rare disease, reference sequence, refseq, snomed ct, syndrome, undiagnosed diseases, x-linked recessive" /><meta name="description" content="Exaggerated convexity of the cervical vertebral column, causing the cervical spine to bow outwards and take on a rounded appearance." /><meta name="robots" content="index,nofollow,noarchive" />
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<!--
UID=107898
ConceptID=C0575170
-->
<!--imgCountBooks = 0--><h1 class="medgenTitle"><div class="MedGenTitleText">Cervical kyphosis</div></h1><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>107898</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C0575170</a></dd><dt><span class="dotprefix"></span></dt><dd>Finding</dd></dl></div></div><table class="medgenTable"><tbody><tr><td>Synonyms:</td>
<td>Kyphosis deformity of cervical spine; Rounded neck</td></tr>
<tr><td><span class="bold">SNOMED CT: </span></td>
<td>Kyphosis deformity of cervical spine (298393001); Cervical kyphosis (298393001)</td></tr>
<tr><td colspan="2" class="small"> </td></tr><tr><td>HPO:</td>
<td><a target="_blank" title="Human Phenotype Ontology" href="https://hpo.jax.org/app/browse/term/HP:0002947">HP:0002947</a></td></tr>
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<div class="portlet mgSection" id="ID_100">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Definition">Definition</h1><a sid="100" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln">Exaggerated convexity of the cervical vertebral column, causing the cervical spine to bow outwards and take on a rounded appearance. [from <a title="Human Phenotype Ontology" href="http://www.human-phenotype-ontology.org" class="defSource" target="_blank">HPO</a>]</div>
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<div class="portlet mgSection" id="ID_118">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Term_Hierarchy">Term Hierarchy</h1><a sid="118" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln HierarchyGTR"><div class="jig-ncbitabs"><ul><li><a href="#tabGTR">GTR</a></li><li><a href="#tabMGEN">MeSH</a></li></ul><div id="tabGTR"><div class="search_result"><div class="rprts"><div class="chiclet_legend"><span class="chiclet_list" style="position:static;"><span title="Clinical test" class="chiclet Ccolor round">C</span><span>Clinical test,  </span><span title="Research test" class="chiclet Rcolor round">R</span><span>Research test,  </span><span title="OMIM" class="chiclet Ocolor ">O</span><span>OMIM,  </span><span title="GeneReview" class="chiclet Gcolor">G</span><span><em>GeneReviews</em>,  </span><span title="ClinVar" class="chiclet Vcolor">V</span><span>ClinVar  </span></span></div><div id="hierarchy" class="margin_t1"><div class="ds_tree"><ul><li class="matched_ds"><span class="chiclet_list"><span class="chiclet unavailable round" title="Clinical test">C</span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet unavailable" title="OMIM">O</span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet unavailable" title="ClinVar">V</span></span><span class="TLline">Cervical kyphosis</span></li></ul></div></div></div></div></div><div id="tabMGEN"><div class="ds_tree"><ul><li><span class="TLline"><a href="/medgen/868760" ref="tree=MeSH" title="MedGen record for Abnormal skeletal morphology">Abnormal skeletal morphology</a></span><ul><li><span class="TLline"><a href="/medgen/892434" ref="tree=MeSH" title="MedGen record for Abnormal axial skeleton morphology">Abnormal axial skeleton morphology</a></span><ul><li><span class="TLline"><a href="/medgen/892426" ref="tree=MeSH" title="MedGen record for Abnormality of the vertebral column">Abnormality of the vertebral column</a></span><ul><li><span class="TLline"><a href="/medgen/371742" ref="tree=MeSH" title="MedGen record for Abnormal vertebral morphology">Abnormal vertebral morphology</a></span><ul><li><span class="TLline"><a href="/medgen/1716336" ref="tree=MeSH" title="MedGen record for Abnormal cervical spine morphology">Abnormal cervical spine morphology</a></span><ul><li><span class="TLline"><a href="/medgen/462873" ref="tree=MeSH" title="MedGen record for Abnormal cervical curvature">Abnormal cervical curvature</a></span><ul><li><span class="matched_ds">Cervical kyphosis</span></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></div></div></div></div>
</div>
<div class="portlet mgSection" id="ID_112">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Conditions_with_this_feature">Conditions with this feature</h1><a sid="112" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln clinfeat">
<div class="divPopper rprt" id="rdis_104500"><div><strong>Larsen syndrome</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>104500</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C0175778</a></dd><dt><span class="dotprefix"></span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
<div class="spaceAbove">The FLNB disorders include a spectrum of phenotypes ranging from mild to severe. At the mild end are spondylocarpotarsal synostosis (SCT) syndrome and Larsen syndrome; at the severe end are the phenotypic continuum of atelosteogenesis types I (AOI) and III (AOIII) and Piepkorn osteochondrodysplasia (POCD). SCT syndrome is characterized by postnatal disproportionate short stature, scoliosis and lordosis, clubfeet, hearing loss, dental enamel hypoplasia, carpal and tarsal synostosis, and vertebral fusions. Larsen syndrome is characterized by congenital dislocations of the hip, knee, and elbow; clubfeet (equinovarus or equinovalgus foot deformities); scoliosis and cervical kyphosis, which can be associated with a cervical myelopathy; short, broad, spatulate distal phalanges; distinctive craniofacies (prominent forehead, depressed nasal bridge, malar flattening, and widely spaced eyes); vertebral anomalies; and supernumerary carpal and tarsal bone ossification centers. Individuals with SCT syndrome and Larsen syndrome can have midline cleft palate and hearing loss. AOI and AOIII are characterized by severe short-limbed dwarfism; dislocated hips, knees, and elbows; and clubfeet. AOI is lethal in the perinatal period. In individuals with AOIII, survival beyond the neonatal period is possible with intensive and invasive respiratory support. Piepkorn osteochondrodysplasia (POCD) is a perinatal-lethal micromelic dwarfism characterized by flipper-like limbs (polysyndactyly with complete syndactyly of all fingers and toes, hypoplastic or absent first digits, and duplicated intermediate and distal phalanges), macrobrachycephaly, prominant forehead, hypertelorism, and exophthalmos. Occasional features include cleft palate, omphalocele, and cardiac and genitourinary anomalies. The radiographic features at mid-gestation are characteristic.</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/104500">Condition Record</a></div></div>
<div class="divPopper rprt" id="rdis_113103"><div><strong>Diastrophic dysplasia</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>113103</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C0220726</a></dd><dt><span class="dotprefix"></span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
<div class="spaceAbove">Diastrophic dysplasia (DTD) is characterized by limb shortening, normal-sized head, hitchhiker thumbs, spinal deformities (scoliosis, exaggerated lumbar lordosis, cervical kyphosis), and contractures of the large joints with deformities and early-onset osteoarthritis. Other typical findings are ulnar deviation of the fingers, gap between the first and second toes, and clubfoot. On occasion, the disease can be lethal at birth, but most affected individuals survive the neonatal period and develop physical limitations with normal intelligence.</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/113103">Condition Record</a></div></div>
<div class="divPopper rprt" id="rdis_338072"><div><strong>Atelosteogenesis type II</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>338072</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C1850554</a></dd><dt><span class="dotprefix"></span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
<div class="spaceAbove">Clinical features of SLC26A2-related atelosteogenesis include rhizomelic limb shortening with normal-sized skull, hitchhiker thumbs, small chest, protuberant abdomen, cleft palate, and distinctive facial features (midface retrusion, depressed nasal bridge, epicanthus, micrognathia). Other typical findings are ulnar deviation of the fingers, gap between the first and second toes, and clubfoot. SLC26A2-related atelosteogenesis is usually lethal at birth or shortly thereafter due to pulmonary hypoplasia and tracheobronchomalacia. However, it exists in a continuous phenotypic spectrum with SLC26A2-related diastrophic dysplasia, and long-term survivors have been reported.</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/338072">Condition Record</a></div></div>
<div class="divPopper rprt" id="rdis_354620"><div><strong>Camptomelic dysplasia</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>354620</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information."><span class="highlight" style="background-color:">C1861922</span></a></dd><dt><span class="dotprefix"></span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
<div class="spaceAbove">Campomelic dysplasia (CD) is a skeletal dysplasia characterized by distinctive facies, Pierre Robin sequence with cleft palate, shortening and bowing of long bones, and clubfeet. Other findings include laryngotracheomalacia with respiratory compromise and ambiguous genitalia or normal female external genitalia in most individuals with a 46,XY karyotype. Many affected infants die in the neonatal period; additional findings identified in long-term survivors include short stature, cervical spine instability with cord compression, progressive scoliosis, and hearing impairment.</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/354620">Condition Record</a></div></div>
<div class="divPopper rprt" id="rdis_777149"><div><strong>Atelosteogenesis type III</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>777149</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C3668942</a></dd><dt><span class="dotprefix"></span></dt><dd>Congenital Abnormality</dd></dl></div></div></div>
<div class="spaceAbove">The FLNB disorders include a spectrum of phenotypes ranging from mild to severe. At the mild end are spondylocarpotarsal synostosis (SCT) syndrome and Larsen syndrome; at the severe end are the phenotypic continuum of atelosteogenesis types I (AOI) and III (AOIII) and Piepkorn osteochondrodysplasia (POCD). SCT syndrome is characterized by postnatal disproportionate short stature, scoliosis and lordosis, clubfeet, hearing loss, dental enamel hypoplasia, carpal and tarsal synostosis, and vertebral fusions. Larsen syndrome is characterized by congenital dislocations of the hip, knee, and elbow; clubfeet (equinovarus or equinovalgus foot deformities); scoliosis and cervical kyphosis, which can be associated with a cervical myelopathy; short, broad, spatulate distal phalanges; distinctive craniofacies (prominent forehead, depressed nasal bridge, malar flattening, and widely spaced eyes); vertebral anomalies; and supernumerary carpal and tarsal bone ossification centers. Individuals with SCT syndrome and Larsen syndrome can have midline cleft palate and hearing loss. AOI and AOIII are characterized by severe short-limbed dwarfism; dislocated hips, knees, and elbows; and clubfeet. AOI is lethal in the perinatal period. In individuals with AOIII, survival beyond the neonatal period is possible with intensive and invasive respiratory support. Piepkorn osteochondrodysplasia (POCD) is a perinatal-lethal micromelic dwarfism characterized by flipper-like limbs (polysyndactyly with complete syndactyly of all fingers and toes, hypoplastic or absent first digits, and duplicated intermediate and distal phalanges), macrobrachycephaly, prominant forehead, hypertelorism, and exophthalmos. Occasional features include cleft palate, omphalocele, and cardiac and genitourinary anomalies. The radiographic features at mid-gestation are characteristic.</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/777149">Condition Record</a></div></div>
<div class="divPopper rprt" id="rdis_899713"><div><strong>Spondylocostal dysostosis 6, autosomal recessive</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>899713</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C4225279</a></dd><dt><span class="dotprefix"></span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
<div class="spaceAbove">Spondylocostal dysostosis (SCDO), defined radiographically as multiple segmentation defects of the vertebrae in combination with abnormalities of the ribs, is characterized clinically by a short trunk in proportion to height; short neck; and non-progressive mild scoliosis in most affected individuals rarely, more significant scoliosis occurs. Respiratory function in neonates with severe disease may be compromised by reduced size of the thorax. By age two years lung growth may improve sufficiently to support relatively normal growth and development. In severely affected individuals with restricted pulmonary capacity, there is a possibility that pulmonary hypertension may eventually impact cardiac function. Males with SCDO appear to be at increased risk for inguinal hernia.</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/899713">Condition Record</a></div></div>
<div class="divPopper rprt" id="rdis_1621331"><div><strong>Joint laxity, short stature, and myopia</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1621331</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C4540020</a></dd><dt><span class="dotprefix"></span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
<div class="spaceAbove">A rare developmental defect with connective tissue involvement and characteristics of joint hyperextensibility and multiple dislocations of large joints, severe myopia and short stature. Other common features include retinal detachment, iris and chorioretinal coloboma, kyphoscoliosis and other spine deformities, pectus carinatum, talipes equinovarus and progressive hearing loss.</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/1621331">Condition Record</a></div></div>
<div class="divPopper rprt" id="rdis_1647990"><div><strong>Schwartz-Jampel syndrome type 1</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1647990</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C4551479</a></dd><dt><span class="dotprefix"></span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
<div class="spaceAbove">Schwartz-Jampel syndrome type 1 (SJS1) is a rare autosomal recessive disorder characterized by muscle stiffness (myotonia) and chondrodysplasia. Affected individuals usually present in childhood with permanent muscle stiffness or bone deformities. Common clinical features include mask-like facies (narrow palpebral fissures, blepharospasm, and pursed lips); permanent muscle stiffness with continuous skeletal muscle activity recorded on electromyography; dwarfism; pectus carinatum; kyphoscoliosis; bowing of long bones; and epiphyseal, metaphyseal, and hip dysplasia. The disorder is slowly progressive but does not appear to alter life span (summary by Stum et al., 2006).</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/1647990">Condition Record</a></div></div>
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_338072" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Atelosteogenesis type II</a></div>
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_777149" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Atelosteogenesis type III</a></div>
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_354620" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Camptomelic dysplasia</a></div>
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_113103" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Diastrophic dysplasia</a></div>
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1621331" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Joint laxity, short stature, and myopia</a></div>
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_104500" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Larsen syndrome</a></div>
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1647990" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Schwartz-Jampel syndrome type 1</a></div>
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_899713" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Spondylocostal dysostosis 6, autosomal recessive</a></div></div>
</div>
<div class="portlet mgSection" id="ID_105">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Professional_guidelines">Professional guidelines</h1><a sid="105" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln"><h3 class="subhead">PubMed<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpPM"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3>
<div class="nl"><a target="_blank" href="/pubmed/37597042">Conservative treatment for dropped head syndrome.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Miyamoto H,
Ikeda T,
Akagi M</span><br />
<span class="medgenPMjournal">Eur Spine J</span>
2023 Oct;32(10):3505-3510.
Epub 2023 Aug 19
doi: 10.1007/s00586-023-07890-3.
<span class="bold">PMID: </span><a href="/pubmed/37597042" target="_blank">37597042</a></div>
<div class="nl"><a target="_blank" href="/pubmed/30971275">Progression of local kyphosis after conservative treatment for compressive cervical spine fracture with spinal cord injury.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Yokota K,
Maeda T,
Kawano O,
Mori E,
Takao T,
Sakai H,
Masuda M,
Morishita Y,
Hayashi T,
Kubota K,
Nakashima Y</span><br />
<span class="medgenPMjournal">J Orthop Surg Res</span>
2019 Apr 11;14(1):98.
doi: 10.1186/s13018-019-1115-z.
<span class="bold">PMID: </span><a href="/pubmed/30971275" target="_blank">30971275</a><a href="/pmc/articles/PMC6458645" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/22955408">Surgical management of congenital cervical kyphosis.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">He Z,
Liu Y,
Xue F,
Xiao H,
Yuan W,
Chen D</span><br />
<span class="medgenPMjournal">Orthopedics</span>
2012 Sep;35(9):e1396-401.
doi: 10.3928/01477447-20120822-28.
<span class="bold">PMID: </span><a href="/pubmed/22955408" target="_blank">22955408</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(%22cervical%20kyphosis%22%5Btiab%3A~0%5D)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">See all (8)</a></div></div>
</div>
<div class="display-none help-popup" id="guidelinesHelpPM">These guidelines are articles in PubMed that match specific search criteria developed by MedGen to capture the most relevant practice guidelines. This list may not be comprehensive and may include broader topics as well. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div><div class="display-none help-popup" id="guidelinesHelpCurated">These guidelines are manually curated by the MedGen team
to supplement articles available in PubMed. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div>
<div class="portlet mgSection" id="ID_103">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_clinical_studies">Recent clinical studies</h1><a sid="103" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln"><h3 class="subhead">Etiology</h3>
<div class="nl"><a target="_blank" href="/pubmed/38825607">Cervical kyphosis after posterior cervical laminectomy with and without fusion.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Jentzsch T,
Wetzel OT,
Malhotra AK,
Lozano CS,
Massicotte EM,
Spirig JM,
Fehlings MG,
Farshad M</span><br />
<span class="medgenPMjournal">Eur Spine J</span>
2024 Aug;33(8):3109-3116.
Epub 2024 Jun 2
doi: 10.1007/s00586-024-08260-3.
<span class="bold">PMID: </span><a href="/pubmed/38825607" target="_blank">38825607</a></div>
<div class="nl"><a target="_blank" href="/pubmed/35385788">Cervical foraminal stenosis as a risk factor for cervical kyphosis following cervical laminoplasty.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Seo J,
Suk KS,
Kwon JW,
Kim N,
Lee BH,
Moon SH,
Kim HS,
Lee HM</span><br />
<span class="medgenPMjournal">Spine J</span>
2022 Aug;22(8):1271-1280.
Epub 2022 Apr 3
doi: 10.1016/j.spinee.2022.03.017.
<span class="bold">PMID: </span><a href="/pubmed/35385788" target="_blank">35385788</a></div>
<div class="nl"><a target="_blank" href="/pubmed/34190114">Cervical kyphosis in patients with thoracic idiopathic scoliosis.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Janusz P,
Stepniak Ł,
Kotwicki T</span><br />
<span class="medgenPMjournal">Stud Health Technol Inform</span>
2021 Jun 28;280:278-279.
doi: 10.3233/SHTI210498.
<span class="bold">PMID: </span><a href="/pubmed/34190114" target="_blank">34190114</a></div>
<div class="nl"><a target="_blank" href="/pubmed/23732179">Complications and Outcomes for Surgical Approaches to Cervical Kyphosis.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Grosso MJ,
Hwang R,
Krishnaney AA,
Mroz TE,
Benzel EC,
Steinmetz MP</span><br />
<span class="medgenPMjournal">J Spinal Disord Tech</span>
2015 Aug;28(7):E385-93.
doi: 10.1097/BSD.0b013e318299953f.
<span class="bold">PMID: </span><a href="/pubmed/23732179" target="_blank">23732179</a></div>
<div class="nl"><a target="_blank" href="/pubmed/20515348">Hirayama disease.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Lin MS,
Kung WM,
Chiu WT,
Lyu RK,
Chen CJ,
Chen TY</span><br />
<span class="medgenPMjournal">J Neurosurg Spine</span>
2010 Jun;12(6):629-34.
doi: 10.3171/2009.12.SPINE09431.
<span class="bold">PMID: </span><a href="/pubmed/20515348" target="_blank">20515348</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Cervical%20kyphosis%22%20AND%20Etiology%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (247)</a></div><h3 class="subhead">Diagnosis</h3>
<div class="nl"><a target="_blank" href="/pubmed/37391518">Cervical kyphosis correction in Marfan syndrome: our experience and literature review.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Kumarasamy S,
Sawarkar DP,
Singh PK,
Kumar R,
Chandra PS,
Kale SS</span><br />
<span class="medgenPMjournal">Childs Nerv Syst</span>
2024 Feb;40(2):495-502.
Epub 2023 Jul 1
doi: 10.1007/s00381-023-06046-4.
<span class="bold">PMID: </span><a href="/pubmed/37391518" target="_blank">37391518</a></div>
<div class="nl"><a target="_blank" href="/pubmed/37757942">Risk Factors for Postoperative Loss of Lordosis, Cervical Kyphosis, and Sagittal Imbalance After Cervical Laminoplasty.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Lee DH,
Park S,
Cho JH,
Hwang CJ,
Yang JJ,
Lee CS</span><br />
<span class="medgenPMjournal">World Neurosurg</span>
2023 Dec;180:e324-e333.
Epub 2023 Sep 25
doi: 10.1016/j.wneu.2023.09.068.
<span class="bold">PMID: </span><a href="/pubmed/37757942" target="_blank">37757942</a></div>
<div class="nl"><a target="_blank" href="/pubmed/36115686">Dysplasias in the Child's Spine.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Campbell JW</span><br />
<span class="medgenPMjournal">Neurosurg Clin N Am</span>
2022 Jan;33(1S):e1-e10.
Epub 2022 Aug 6
doi: 10.1016/j.nec.2022.02.001.
<span class="bold">PMID: </span><a href="/pubmed/36115686" target="_blank">36115686</a></div>
<div class="nl"><a target="_blank" href="/pubmed/20515348">Hirayama disease.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Lin MS,
Kung WM,
Chiu WT,
Lyu RK,
Chen CJ,
Chen TY</span><br />
<span class="medgenPMjournal">J Neurosurg Spine</span>
2010 Jun;12(6):629-34.
doi: 10.3171/2009.12.SPINE09431.
<span class="bold">PMID: </span><a href="/pubmed/20515348" target="_blank">20515348</a></div>
<div class="nl"><a target="_blank" href="/pubmed/2644305">Spinal abnormalities in camptomelic dysplasia.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Coscia MF,
Bassett GS,
Bowen JR,
Ogilvie JW,
Winter RB,
Simonton SC</span><br />
<span class="medgenPMjournal">J Pediatr Orthop</span>
1989 Jan-Feb;9(1):6-14.
doi: 10.1097/01241398-198901000-00002.
<span class="bold">PMID: </span><a href="/pubmed/2644305" target="_blank">2644305</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Cervical%20kyphosis%22%20AND%20Diagnosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (96)</a></div><h3 class="subhead">Therapy</h3>
<div class="nl"><a target="_blank" href="/pubmed/38825607">Cervical kyphosis after posterior cervical laminectomy with and without fusion.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Jentzsch T,
Wetzel OT,
Malhotra AK,
Lozano CS,
Massicotte EM,
Spirig JM,
Fehlings MG,
Farshad M</span><br />
<span class="medgenPMjournal">Eur Spine J</span>
2024 Aug;33(8):3109-3116.
Epub 2024 Jun 2
doi: 10.1007/s00586-024-08260-3.
<span class="bold">PMID: </span><a href="/pubmed/38825607" target="_blank">38825607</a></div>
<div class="nl"><a target="_blank" href="/pubmed/35385788">Cervical foraminal stenosis as a risk factor for cervical kyphosis following cervical laminoplasty.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Seo J,
Suk KS,
Kwon JW,
Kim N,
Lee BH,
Moon SH,
Kim HS,
Lee HM</span><br />
<span class="medgenPMjournal">Spine J</span>
2022 Aug;22(8):1271-1280.
Epub 2022 Apr 3
doi: 10.1016/j.spinee.2022.03.017.
<span class="bold">PMID: </span><a href="/pubmed/35385788" target="_blank">35385788</a></div>
<div class="nl"><a target="_blank" href="/pubmed/29096033">Cervical Spine Deformity-Part 3: Posterior Techniques, Clinical Outcome, and Complications.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Tan LA,
Riew KD,
Traynelis VC</span><br />
<span class="medgenPMjournal">Neurosurgery</span>
2017 Dec 1;81(6):893-898.
doi: 10.1093/neuros/nyx477.
<span class="bold">PMID: </span><a href="/pubmed/29096033" target="_blank">29096033</a></div>
<div class="nl"><a target="_blank" href="/pubmed/25613637">Serious and long-term adverse events associated with the therapeutic and cosmetic use of botulinum toxin.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Yiannakopoulou E</span><br />
<span class="medgenPMjournal">Pharmacology</span>
2015;95(1-2):65-9.
Epub 2015 Jan 21
doi: 10.1159/000370245.
<span class="bold">PMID: </span><a href="/pubmed/25613637" target="_blank">25613637</a></div>
<div class="nl"><a target="_blank" href="/pubmed/23732179">Complications and Outcomes for Surgical Approaches to Cervical Kyphosis.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Grosso MJ,
Hwang R,
Krishnaney AA,
Mroz TE,
Benzel EC,
Steinmetz MP</span><br />
<span class="medgenPMjournal">J Spinal Disord Tech</span>
2015 Aug;28(7):E385-93.
doi: 10.1097/BSD.0b013e318299953f.
<span class="bold">PMID: </span><a href="/pubmed/23732179" target="_blank">23732179</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Cervical%20kyphosis%22%20AND%20Therapy%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (92)</a></div><h3 class="subhead">Prognosis</h3>
<div class="nl"><a target="_blank" href="/pubmed/37757942">Risk Factors for Postoperative Loss of Lordosis, Cervical Kyphosis, and Sagittal Imbalance After Cervical Laminoplasty.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Lee DH,
Park S,
Cho JH,
Hwang CJ,
Yang JJ,
Lee CS</span><br />
<span class="medgenPMjournal">World Neurosurg</span>
2023 Dec;180:e324-e333.
Epub 2023 Sep 25
doi: 10.1016/j.wneu.2023.09.068.
<span class="bold">PMID: </span><a href="/pubmed/37757942" target="_blank">37757942</a></div>
<div class="nl"><a target="_blank" href="/pubmed/28760029">Keyhole approaches to intradural pathologies.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Mende KC,
Krätzig T,
Mohme M,
Westphal M,
Eicker SO</span><br />
<span class="medgenPMjournal">Neurosurg Focus</span>
2017 Aug;43(2):E5.
doi: 10.3171/2017.5.FOCUS17198.
<span class="bold">PMID: </span><a href="/pubmed/28760029" target="_blank">28760029</a></div>
<div class="nl"><a target="_blank" href="/pubmed/20515348">Hirayama disease.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Lin MS,
Kung WM,
Chiu WT,
Lyu RK,
Chen CJ,
Chen TY</span><br />
<span class="medgenPMjournal">J Neurosurg Spine</span>
2010 Jun;12(6):629-34.
doi: 10.3171/2009.12.SPINE09431.
<span class="bold">PMID: </span><a href="/pubmed/20515348" target="_blank">20515348</a></div>
<div class="nl"><a target="_blank" href="/pubmed/8168889">Post-traumatic cervical kyphosis in children cannot be prevented by non-operative methods.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Schwarz N,
Genelin F,
Schwarz AF</span><br />
<span class="medgenPMjournal">Injury</span>
1994 Apr;25(3):173-5.
doi: 10.1016/0020-1383(94)90156-2.
<span class="bold">PMID: </span><a href="/pubmed/8168889" target="_blank">8168889</a></div>
<div class="nl"><a target="_blank" href="/pubmed/3187709">Treatment of cervical kyphosis in children.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Francis WR Jr,
Noble DP</span><br />
<span class="medgenPMjournal">Spine (Phila Pa 1976)</span>
1988 Aug;13(8):883-7.
doi: 10.1097/00007632-198808000-00001.
<span class="bold">PMID: </span><a href="/pubmed/3187709" target="_blank">3187709</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Cervical%20kyphosis%22%20AND%20Prognosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (116)</a></div><h3 class="subhead">Clinical prediction guides</h3>
<div class="nl"><a target="_blank" href="/pubmed/38252256">Correction of pediatric cervical kyphosis: our experience and systematic-literature review.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Kumarasamy S,
Sawarkar DP,
Singh PK,
Kumar R,
Chandra PS,
Kale SS</span><br />
<span class="medgenPMjournal">Spine Deform</span>
2024 May;12(3):603-620.
Epub 2024 Jan 22
doi: 10.1007/s43390-023-00809-4.
<span class="bold">PMID: </span><a href="/pubmed/38252256" target="_blank">38252256</a></div>
<div class="nl"><a target="_blank" href="/pubmed/35385788">Cervical foraminal stenosis as a risk factor for cervical kyphosis following cervical laminoplasty.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Seo J,
Suk KS,
Kwon JW,
Kim N,
Lee BH,
Moon SH,
Kim HS,
Lee HM</span><br />
<span class="medgenPMjournal">Spine J</span>
2022 Aug;22(8):1271-1280.
Epub 2022 Apr 3
doi: 10.1016/j.spinee.2022.03.017.
<span class="bold">PMID: </span><a href="/pubmed/35385788" target="_blank">35385788</a></div>
<div class="nl"><a target="_blank" href="/pubmed/29330570">Open-door laminoplasty : What can the unilateral approach offer?</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Kothe R,
Schmeiser G,
Papavero L</span><br />
<span class="medgenPMjournal">Oper Orthop Traumatol</span>
2018 Feb;30(1):3-12.
Epub 2018 Jan 12
doi: 10.1007/s00064-017-0527-3.
<span class="bold">PMID: </span><a href="/pubmed/29330570" target="_blank">29330570</a></div>
<div class="nl"><a target="_blank" href="/pubmed/23732179">Complications and Outcomes for Surgical Approaches to Cervical Kyphosis.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Grosso MJ,
Hwang R,
Krishnaney AA,
Mroz TE,
Benzel EC,
Steinmetz MP</span><br />
<span class="medgenPMjournal">J Spinal Disord Tech</span>
2015 Aug;28(7):E385-93.
doi: 10.1097/BSD.0b013e318299953f.
<span class="bold">PMID: </span><a href="/pubmed/23732179" target="_blank">23732179</a></div>
<div class="nl"><a target="_blank" href="/pubmed/24113358">Cervical radiographical alignment: comprehensive assessment techniques and potential importance in cervical myelopathy.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Ames CP,
Blondel B,
Scheer JK,
Schwab FJ,
Le Huec JC,
Massicotte EM,
Patel AA,
Traynelis VC,
Kim HJ,
Shaffrey CI,
Smith JS,
Lafage V</span><br />
<span class="medgenPMjournal">Spine (Phila Pa 1976)</span>
2013 Oct 15;38(22 Suppl 1):S149-60.
doi: 10.1097/BRS.0b013e3182a7f449.
<span class="bold">PMID: </span><a href="/pubmed/24113358" target="_blank">24113358</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Cervical%20kyphosis%22%20AND%20Clinical%20prediction%20guides%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (166)</a></div></div>
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Sawarkar DP,
Singh PK,
Kumar R,
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<span class="medgenPMjournal">Spine Deform</span>
2024 May;12(3):603-620.
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<div class="nl"><a target="_blank" href="/pubmed/35472680">Postoperative spinal deformity and instability after cervical spinal cord tumor resection in adults: A systematic review and meta-analysis.</a></div>
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Takahashi T,
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Ha Y</span><br />
<span class="medgenPMjournal">J Clin Neurosci</span>
2022 Jun;100:148-154.
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<div class="nl"><a target="_blank" href="/pubmed/35132000">Spinal screening, malignancy, medical therapy, and surgical correction of deformity in pediatric patients with neurofibromatosis type 1: a systematic review.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Suresh KV,
Xu AL,
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2022 Nov 1;31(6):572-582.
Epub 2022 Feb 7
doi: 10.1097/BPB.0000000000000961.
<span class="bold">PMID: </span><a href="/pubmed/35132000" target="_blank">35132000</a></div>
<div class="nl"><a target="_blank" href="/pubmed/23657624">Anterior approach versus posterior approach for the treatment of multilevel cervical spondylotic myelopathy: a systemic review and meta-analysis.</a></div>
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Xu Y,
Liu X,
Liu Z,
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<span class="medgenPMjournal">Eur Spine J</span>
2013 Jul;22(7):1583-93.
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doi: 10.1007/s00586-013-2817-2.
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<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Cervical%20kyphosis%22%20AND%20systematic%5Bsb%5D%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (4)</a></div></div>
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