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<!--
|
||
UID=10501
|
||
ConceptID=C0029463
|
||
-->
|
||
<!--imgCountBooks = 0--><h1 class="medgenTitle"><div class="MedGenTitleText">Osteosarcoma<span class="h1sub">(OSRC)</span></div></h1><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>10501</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0029463</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Neoplastic Process</dd></dl></div></div><table class="medgenTable"><tbody><tr><td>Synonym:</td>
|
||
<td>Osteosarcoma (disease)</td></tr>
|
||
<tr><td><span class="bold">SNOMED CT: </span></td>
|
||
<td>Osteosarcoma (189878003); Osteoblastic sarcoma (1163405004); Osteogenic sarcoma (1163405004); Osteochondrosarcoma (1163405004); Osteosarcoma (1163405004); Osteoblastic osteosarcoma (1163405004)</td></tr>
|
||
<tr><td colspan="2" class="small"> </td></tr><tr><td>HPO:</td>
|
||
<td><a target="_blank" title="Human Phenotype Ontology" href="https://hpo.jax.org/app/browse/term/HP:0002669">HP:0002669</a></td></tr>
|
||
<tr><td>Monarch Initiative:</td>
|
||
<td><a href="https://monarchinitiative.org/disease/MONDO:0009807" target="_blank">MONDO:0009807</a></td></tr>
|
||
<tr><td>OMIM<span class="superscript">®</span>:</td>
|
||
<td><a href="https://omim.org/entry/191170" target="_blank">191170</a>; <a href="https://omim.org/entry/259500" target="_blank">259500</a></td></tr>
|
||
</tbody></table></div><div class="rprt-body jig-ncbiinpagenav" data-jigconfig="smoothScroll: false, gotoTopLink: true, gotoTopLinkText: '', gotoTopLinkAttrs: {'title': 'Go to the top of the page'},allHeadingLevels: ['h1'], topOfPageTOC: true, tocId: 'my-toc'"><div id="rprt-tabs-1" class="rprt-tab"><div id="tb-termsProp-1"><div class="leftCol mgCol"><div>
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<div class="portlet mgSection" id="ID_100">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Definition">Definition</h1><a sid="100" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln">A malignant bone tumor that usually develops during adolescence and usually affects the long bones including the tibia, femur, and humerus. The typical symptoms of osteosarcoma comprise bone pain, fracture, limitation of motion, and tenderness or swelling at the site of the tumor. [from <a title="Human Phenotype Ontology" href="http://www.human-phenotype-ontology.org" class="defSource" target="_blank">HPO</a>]</div>
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</div>
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<div class="portlet mgSection" id="ID_118">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Term_Hierarchy">Term Hierarchy</h1><a sid="118" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
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<div class="portlet_content ln HierarchyGTR"><div class="jig-ncbitabs"><ul><li><a href="#tabGTR">GTR</a></li><li><a href="#tabMGEN">MeSH</a></li><li><a href="#tabORDO">Orphanet</a></li></ul><div id="tabGTR"><div class="search_result"><div class="rprts"><div class="chiclet_legend"><span class="chiclet_list" style="position:static;"><span title="Clinical test" class="chiclet Ccolor round">C</span><span>Clinical test, </span><span title="Research test" class="chiclet Rcolor round">R</span><span>Research test, </span><span title="OMIM" class="chiclet Ocolor ">O</span><span>OMIM, </span><span title="GeneReview" class="chiclet Gcolor">G</span><span><em>GeneReviews</em>, </span><span title="ClinVar" class="chiclet Vcolor">V</span><span>ClinVar </span></span></div><div id="hierarchy" class="margin_t1"><div class="ds_tree"><ul><li class="matched_ds"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C0029463[DISCUI]&test_type=Clinical" ref="ncbi_uid=10501">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet Ocolor" title="OMIM"><a ref="ncbi_uid=10501" target="_blank" href="/omim/191170">O</a></span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&from_uid=10501" ref="ncbi_uid=10501">V</a></span></span><span class="TLline">Osteosarcoma</span></li></ul></div></div></div></div></div><div id="tabMGEN"><div class="ds_tree"><ul><li><span class="TLline"><a href="/medgen/21047" ref="tree=MeSH" title="MedGen record for Pathological Conditions, Signs and Symptoms">Pathological Conditions, Signs and Symptoms</a></span><ul><li><span class="TLline"><a href="/medgen/18325" ref="tree=MeSH" title="MedGen record for Pathological process">Pathological process</a></span><ul><li><span class="TLline"><a href="/medgen/4347" ref="tree=MeSH" title="MedGen record for Disease">Disease</a></span><ul><li><span class="TLline"><a href="/medgen/10294" ref="tree=MeSH" title="MedGen record for Neoplasm">Neoplasm</a></span><ul><li><span class="matched_ds">Osteosarcoma</span><ul><li><span class="TLline"><a href="/medgen/108437" ref="tree=MeSH" title="MedGen record for Bone osteosarcoma">Bone osteosarcoma</a></span><ul><li><span class="TLline"><a href="/medgen/1734379" ref="tree=MeSH" title="MedGen record for Maxillofacial Osteosarcoma">Maxillofacial Osteosarcoma</a></span></li><li><span class="TLline"><a href="/medgen/233695" ref="tree=MeSH" title="MedGen record for Metachronous osteosarcoma of the bone">Metachronous osteosarcoma of the bone</a></span></li><li><span class="TLline"><a href="/medgen/309945" ref="tree=MeSH" title="MedGen record for Primary Bone Osteosarcoma">Primary Bone Osteosarcoma</a></span><ul><li><span class="TLline"><a href="/medgen/220429" ref="tree=MeSH" title="MedGen record for Conventional central osteosarcoma">Conventional central osteosarcoma</a></span></li><li><span class="TLline"><a href="/medgen/233199" ref="tree=MeSH" title="MedGen record for Multifocal osteogenic sarcoma">Multifocal osteogenic sarcoma</a></span></li><li><span class="TLline"><a href="/medgen/1625155" ref="tree=MeSH" title="MedGen record for Osteosarcoma by AJCC v7 Stage">Osteosarcoma by AJCC v7 Stage</a></span></li><li><span class="TLline"><a href="/medgen/272379" ref="tree=MeSH" title="MedGen record for Peripheral osteosarcoma">Peripheral osteosarcoma</a></span></li><li><span class="TLline"><a href="/medgen/83532" ref="tree=MeSH" title="MedGen record for Small cell osteogenic sarcoma">Small cell osteogenic sarcoma</a></span></li><li><span class="TLline"><a href="/medgen/78059" ref="tree=MeSH" title="MedGen record for Telangiectatic osteogenic sarcoma">Telangiectatic osteogenic sarcoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/313693" ref="tree=MeSH" title="MedGen record for Secondary Osteosarcoma">Secondary Osteosarcoma</a></span><ul><li><span class="TLline"><a href="/medgen/569679" ref="tree=MeSH" title="MedGen record for Osteosarcoma arising in bone Paget disease">Osteosarcoma arising in bone Paget disease</a></span></li><li><span class="TLline"><a href="/medgen/313600" ref="tree=MeSH" title="MedGen record for Radiation-Related Osteosarcoma">Radiation-Related Osteosarcoma</a></span></li></ul></li></ul></li><li><span class="TLline"><a href="/medgen/107816" ref="tree=MeSH" title="MedGen record for Ewing sarcoma">Ewing sarcoma</a></span><ul><li><span class="TLline"><a href="/medgen/785386" ref="tree=MeSH" title="MedGen record for Atypical Ewing Sarcoma">Atypical Ewing Sarcoma</a></span></li><li><span class="TLline"><a href="/medgen/108438" ref="tree=MeSH" title="MedGen record for Ewing sarcoma of bone">Ewing sarcoma of bone</a></span><ul><li><span class="TLline"><a href="/medgen/233615" ref="tree=MeSH" title="MedGen record for Localized Bone Ewing Sarcoma">Localized Bone Ewing Sarcoma</a></span></li><li><span class="TLline"><a href="/medgen/233698" ref="tree=MeSH" title="MedGen record for Metastatic Bone Ewing Sarcoma">Metastatic Bone Ewing Sarcoma</a></span></li><li><span class="TLline"><a href="/medgen/233908" ref="tree=MeSH" title="MedGen record for Recurrent Bone Ewing Sarcoma">Recurrent Bone Ewing Sarcoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/76053" ref="tree=MeSH" title="MedGen record for Extraskeletal Ewing sarcoma">Extraskeletal Ewing sarcoma</a></span><ul><li><span class="TLline"><a href="/medgen/1702234" ref="tree=MeSH" title="MedGen record for Kidney Ewing Sarcoma">Kidney Ewing Sarcoma</a></span></li><li><span class="TLline"><a href="/medgen/163505" ref="tree=MeSH" title="MedGen record for Localized Extraskeletal Ewing Sarcoma">Localized Extraskeletal Ewing Sarcoma</a></span></li><li><span class="TLline"><a href="/medgen/163504" ref="tree=MeSH" title="MedGen record for Metastatic Extraskeletal Ewing Sarcoma">Metastatic Extraskeletal Ewing Sarcoma</a></span></li><li><span class="TLline"><a href="/medgen/208944" ref="tree=MeSH" title="MedGen record for Recurrent Extraskeletal Ewing Sarcoma">Recurrent Extraskeletal Ewing Sarcoma</a></span></li><li><span class="TLline"><a href="/medgen/1762969" ref="tree=MeSH" title="MedGen record for Skin Ewing Sarcoma">Skin Ewing Sarcoma</a></span></li><li><span class="TLline"><a href="/medgen/1793842" ref="tree=MeSH" title="MedGen record for Vulvar Ewing Sarcoma">Vulvar Ewing Sarcoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/167841" ref="tree=MeSH" title="MedGen record for Localized Ewing Sarcoma">Localized Ewing Sarcoma</a></span></li><li><span class="TLline"><a href="/medgen/75839" ref="tree=MeSH" title="MedGen record for Metastatic Ewing Sarcoma">Metastatic Ewing Sarcoma</a></span><ul><li><span class="TLline"><a href="/medgen/1717811" ref="tree=MeSH" title="MedGen record for Locally Advanced Ewing Sarcoma">Locally Advanced Ewing Sarcoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/78850" ref="tree=MeSH" title="MedGen record for Recurrent Ewing Sarcoma">Recurrent Ewing Sarcoma</a></span></li><li><span class="TLline"><a href="/medgen/1631504" ref="tree=MeSH" title="MedGen record for Refractory Ewing Sarcoma">Refractory Ewing Sarcoma</a></span></li><li><span class="TLline"><a href="/medgen/1387874" ref="tree=MeSH" title="MedGen record for Unresectable Ewing Sarcoma">Unresectable Ewing Sarcoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/163186" ref="tree=MeSH" title="MedGen record for Extraosseous osteosarcoma">Extraosseous osteosarcoma</a></span><ul><li><span class="TLline"><a href="/medgen/83016" ref="tree=MeSH" title="MedGen record for Adult extraskeletal osteosarcoma">Adult extraskeletal osteosarcoma</a></span></li><li><span class="TLline"><a href="/medgen/235414" ref="tree=MeSH" title="MedGen record for Breast extraskeletal osteosarcoma">Breast extraskeletal osteosarcoma</a></span></li><li><span class="TLline"><a href="/medgen/1643049" ref="tree=MeSH" title="MedGen record for Cardiac Extraskeletal Osteosarcoma">Cardiac Extraskeletal Osteosarcoma</a></span></li><li><span class="TLline"><a href="/medgen/233803" ref="tree=MeSH" title="MedGen record for Central nervous system extraskeletal osteosarcoma">Central nervous system extraskeletal osteosarcoma</a></span></li><li><span class="TLline"><a href="/medgen/232060" ref="tree=MeSH" title="MedGen record for Childhood extraosseous osteosarcoma">Childhood extraosseous osteosarcoma</a></span></li><li><span class="TLline"><a href="/medgen/415376" ref="tree=MeSH" title="MedGen record for Duodenal Extraskeletal Osteosarcoma">Duodenal Extraskeletal Osteosarcoma</a></span></li><li><span class="TLline"><a href="/medgen/235547" ref="tree=MeSH" title="MedGen record for Kidney osteogenic sarcoma">Kidney osteogenic sarcoma</a></span></li><li><span class="TLline"><a href="/medgen/232597" ref="tree=MeSH" title="MedGen record for Liver extraskeletal osteosarcoma">Liver extraskeletal osteosarcoma</a></span></li><li><span class="TLline"><a href="/medgen/167761" ref="tree=MeSH" title="MedGen record for Localized Extraskeletal Osteosarcoma">Localized Extraskeletal Osteosarcoma</a></span></li><li><span class="TLline"><a href="/medgen/235314" ref="tree=MeSH" title="MedGen record for Mediastinal extraskeletal osteosarcoma">Mediastinal extraskeletal osteosarcoma</a></span></li><li><span class="TLline"><a href="/medgen/167760" ref="tree=MeSH" title="MedGen record for Metastatic Extraskeletal Osteosarcoma">Metastatic Extraskeletal Osteosarcoma</a></span></li><li><span class="TLline"><a href="/medgen/1692247" ref="tree=MeSH" title="MedGen record for Prostate Osteosarcoma">Prostate Osteosarcoma</a></span></li><li><span class="TLline"><a href="/medgen/208945" ref="tree=MeSH" title="MedGen record for Recurrent Extraskeletal Osteosarcoma">Recurrent Extraskeletal Osteosarcoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/60197" ref="tree=MeSH" title="MedGen record for Juxtacortical osteosarcoma">Juxtacortical osteosarcoma</a></span><ul><li><span class="TLline"><a href="/medgen/272467" ref="tree=MeSH" title="MedGen record for Childhood parosteal osteosarcoma">Childhood parosteal osteosarcoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/124467" ref="tree=MeSH" title="MedGen record for Localized osteosarcoma">Localized osteosarcoma</a></span></li><li><span class="TLline"><a href="/medgen/75830" ref="tree=MeSH" title="MedGen record for Metastatic Osteosarcoma">Metastatic Osteosarcoma</a></span><ul><li><span class="TLline"><a href="/medgen/1785161" ref="tree=MeSH" title="MedGen record for Locally Advanced Osteosarcoma">Locally Advanced Osteosarcoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/272464" ref="tree=MeSH" title="MedGen record for Pediatric osteosarcoma">Pediatric osteosarcoma</a></span><ul><li><span class="TLline"><a href="/medgen/232350" ref="tree=MeSH" title="MedGen record for Childhood intracortical osteosarcoma">Childhood intracortical osteosarcoma</a></span></li><li><span class="TLline"><a href="/medgen/886695" ref="tree=MeSH" title="MedGen record for Childhood Periosteal Osteosarcoma">Childhood Periosteal Osteosarcoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/124509" ref="tree=MeSH" title="MedGen record for Recurrent Osteosarcoma">Recurrent Osteosarcoma</a></span></li><li><span class="TLline"><a href="/medgen/1648182" ref="tree=MeSH" title="MedGen record for Refractory Osteosarcoma">Refractory Osteosarcoma</a></span></li><li><span class="TLline"><a href="/medgen/1693492" ref="tree=MeSH" title="MedGen record for Resectable Osteosarcoma">Resectable Osteosarcoma</a></span></li><li><span class="TLline"><a href="/medgen/1379232" ref="tree=MeSH" title="MedGen record for Unresectable Osteosarcoma">Unresectable Osteosarcoma</a></span></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></div></div><div id="tabORDO">Follow <a target="_blank" href="http://www.orpha.net/consor/cgi-bin/Disease_Classif.php?lng=EN&data_id=156&PatId=3758&search=Disease_Classif_Simple&new=1" class="ital bold">this link</a> to review classifications for <span class="ital">Osteosarcoma</span> in Orphanet.</div></div></div>
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</div>
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<div class="portlet mgSection" id="ID_112">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Conditions_with_this_feature">Conditions with this feature</h1><a sid="112" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="portlet_content ln clinfeat">
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<div class="divPopper rprt" id="rdis_20552"><div><strong>Retinoblastoma</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>20552</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0035335</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Neoplastic Process</dd></dl></div></div></div>
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<div class="spaceAbove">Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is associated with susceptibility for retinoblastoma as well as non-ocular tumors.</div>
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<div class="spaceAbove nowrap">See: <a href="/medgen/20552">Condition Record</a></div></div>
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<div class="divPopper rprt" id="rdis_12147"><div><strong>Werner syndrome</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>12147</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0043119</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
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<div class="spaceAbove">Werner syndrome is characterized by the premature appearance of features associated with normal aging and cancer predisposition. Individuals with Werner syndrome develop normally until the end of the first decade. The first sign is the lack of a growth spurt during the early teen years. Early findings (usually observed in the 20s) include loss and graying of hair, hoarseness, and scleroderma-like skin changes, followed by bilateral ocular cataracts, type 2 diabetes mellitus, hypogonadism, skin ulcers, and osteoporosis in the 30s. Myocardial infarction and cancer are the most common causes of death; the mean age of death in individuals with Werner syndrome is 54 years.</div>
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<div class="spaceAbove nowrap">See: <a href="/medgen/12147">Condition Record</a></div></div>
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<div class="divPopper rprt" id="rdis_64439"><div><strong>Choroid plexus papilloma</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>64439</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0205770</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Neoplastic Process</dd></dl></div></div></div>
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<div class="spaceAbove">Choroid plexus tumors are of neuroectodermal origin and range from benign choroid plexus papillomas (CPPs) to malignant choroid carcinomas (CPCs). These rare tumors generally occur in childhood, but have also been reported in adults. Patients typically present with signs and symptoms of increased intracranial pressure including headache, hydrocephalus, papilledema, nausea, vomiting, cranial nerve deficits, gait impairment, and seizures (summary by Safaee et al., 2013).</div>
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<div class="spaceAbove nowrap">See: <a href="/medgen/64439">Condition Record</a></div></div>
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<div class="divPopper rprt" id="rdis_108437"><div><strong>Bone osteosarcoma</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>108437</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0585442</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Neoplastic Process</dd></dl></div></div></div>
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<div class="spaceAbove">Osteosarcoma is a primary malignant tumour of the skeleton characterised by the direct formation of immature bone or osteoid tissue by the tumour cells.</div>
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<div class="spaceAbove nowrap">See: <a href="/medgen/108437">Condition Record</a></div></div>
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<div class="divPopper rprt" id="rdis_331588"><div><strong>OSLAM syndrome</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>331588</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1833792</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
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<div class="spaceAbove">Syndrome characterized by the association of osteosarcoma, limb anomalies (clinodactyly with brachymesophalangia, bilateral radioulnar synostosis and absence of one digital ray of the foot) and red cell macrocytosis without anemia. It has been described in three out of nine children from one family.</div>
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<div class="spaceAbove nowrap">See: <a href="/medgen/331588">Condition Record</a></div></div>
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<div class="divPopper rprt" id="rdis_322656"><div><strong>Li-Fraumeni syndrome 1</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>322656</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1835398</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
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<div class="spaceAbove">Li-Fraumeni syndrome (LFS) is a cancer predisposition syndrome associated with high risks for a broad spectrum of cancers including early-onset cancers. Five cancer types account for the majority of LFS tumors: adrenocortical carcinomas, breast cancer, central nervous system tumors, osteosarcomas, and soft-tissue sarcomas. Other cancers associated with LFS include leukemia, colorectal cancer, stomach cancer, lung cancer, melanoma, pediatric head and neck cancers, pancreatic cancer, and prostate cancer. Cancer survivors are at increased risk for developing additional primary cancers and treatment-related secondary cancers. The lifetime risks of cancer for women and men with classic LFS are 90% and 70%, respectively, and 50% of cancers occur prior to age 40 years.</div>
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<div class="spaceAbove nowrap">See: <a href="/medgen/322656">Condition Record</a></div></div>
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<div class="divPopper rprt" id="rdis_350613"><div><strong>Diaphyseal medullary stenosis-bone malignancy syndrome</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>350613</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1862177</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
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<div class="spaceAbove">Diaphyseal medullary stenosis with malignant fibrous histiocytoma is an autosomal dominant bone dysplasia characterized by pathologic fractures due to abnormal cortical growth and diaphyseal medullary stenosis. The fractures heal poorly, and there is progressive bowing of the lower extremities. In 2 families, affected individuals also showed a limb-girdle myopathy, with muscle weakness and atrophy. Approximately 35% of affected individuals develop an aggressive form of bone sarcoma consistent with malignant fibrous histiocytoma or osteosarcoma. Thus, the disorder may be considered a tumor predisposition syndrome (summary by Camacho-Vanegas et al., 2012).</div>
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<div class="spaceAbove nowrap">See: <a href="/medgen/350613">Condition Record</a></div></div>
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<div class="divPopper rprt" id="rdis_356468"><div><strong>Premature aging syndrome, Okamoto type</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>356468</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1866183</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
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<div class="spaceAbove nowrap">See: <a href="/medgen/356468">Condition Record</a></div></div>
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<div class="divPopper rprt" id="rdis_390966"><div><strong>Diamond-Blackfan anemia 1</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>390966</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C2676137</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
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<div class="spaceAbove">Diamond-Blackfan anemia (DBA) is characterized by a profound normochromic and usually macrocytic anemia with normal leukocytes and platelets, congenital malformations in up to 50%, and growth deficiency in 30% of affected individuals. The hematologic complications occur in 90% of affected individuals during the first year of life. The phenotypic spectrum ranges from a mild form (e.g., mild anemia or no anemia with only subtle erythroid abnormalities, physical malformations without anemia) to a severe form of fetal anemia resulting in nonimmune hydrops fetalis. DBA is associated with an increased risk for acute myelogenous leukemia (AML), myelodysplastic syndrome (MDS), and solid tumors including osteogenic sarcoma.</div>
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<div class="spaceAbove nowrap">See: <a href="/medgen/390966">Condition Record</a></div></div>
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||
<div class="divPopper rprt" id="rdis_895927"><div><strong>Paget disease of bone 3</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>895927</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C4085252</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
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||
<div class="spaceAbove">Paget disease (PDB) is a metabolic bone disease characterized by focal abnormalities of increased bone turnover affecting one or more sites throughout the skeleton, primarily the axial skeleton. Bone lesions in this disorder show evidence of increased osteoclastic bone resorption and disorganized bone structure. See reviews by Ralston et al. (2008) and Ralston and Albagha (2014). Genetic Heterogeneity of Paget Disease of Bone Also see PDB2 (602080), caused by mutation in the TNFRSF11A gene (603499) on chromosome 18q21; PDB4 (606263), mapped to chromosome 5q31; PDB5 (239000), caused by mutation in the TNFRSF11B gene (602643) on chromosome 8q24; and PDB6 (616833), caused by mutation in the ZNF687 gene (610568) on chromosome 1q21. Suggestive linkage of a form of PDB to chromosome 6p (PDB1) was reported by Fotino et al. (1977); however, further studies did not confirm linkage to this site (Moore and Hoffman, 1988; Nance et al., 2000; Good et al., 2001).</div>
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||
<div class="spaceAbove nowrap">See: <a href="/medgen/895927">Condition Record</a></div></div>
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<div class="divPopper rprt" id="rdis_1684753"><div><strong>Rothmund-Thomson syndrome type 2</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1684753</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C5203410</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
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||
<div class="spaceAbove">Rothmund-Thomson syndrome (RTS) is characterized by a rash that progresses to poikiloderma; sparse hair, eyelashes, and/or eyebrows; small size; skeletal and dental abnormalities; juvenile cataracts; and an increased risk for cancer, especially osteosarcoma. A variety of benign and malignant hematologic abnormalities have been reported in affected individuals. The rash of RTS typically develops between ages three and six months (occasionally as late as age two years) as erythema, swelling, and blistering on the face, subsequently spreading to the buttocks and extremities. The rash evolves over months to years into the chronic pattern of reticulated hypo- and hyperpigmentation, telangiectasias, and punctate atrophy (collectively known as poikiloderma) that persist throughout life. Hyperkeratotic lesions occur in approximately one third of individuals. Skeletal abnormalities can include radial ray defects, ulnar defects, absent or hypoplastic patella, and osteopenia.</div>
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<div class="spaceAbove nowrap">See: <a href="/medgen/1684753">Condition Record</a></div></div>
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||
<div class="divPopper rprt" id="rdis_1824003"><div><strong>Diamond-Blackfan anemia 21</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1824003</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C5774230</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
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||
<div class="spaceAbove">Diamond-Blackfan anemia-21 (DBA21) is an autosomal recessive bone marrow failure syndrome that includes selective erythroid hypoplasia, anemia with transient thrombocytopenia, short stature, facial dysmorphism, limb abnormalities, cardiac defects, and intellectual disability (O'Donohue et al., 2022). For a general phenotypic description and discussion of genetic heterogeneity of Diamond-Blackfan anemia, see DBA1 (105650).</div>
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<div class="spaceAbove nowrap">See: <a href="/medgen/1824003">Condition Record</a></div></div>
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<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_108437" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Bone osteosarcoma</a></div>
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<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_64439" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Choroid plexus papilloma</a></div>
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<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_390966" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Diamond-Blackfan anemia 1</a></div>
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||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1824003" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Diamond-Blackfan anemia 21</a></div>
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||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_350613" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Diaphyseal medullary stenosis-bone malignancy syndrome</a></div><div class="jig-moreless" data-jigconfig="class: 'moveDown', moreText: 'See full list (12)', lessText: 'Show less', nodeBefore: 0"><span id="clinMore">
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_322656" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Li-Fraumeni syndrome 1</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_331588" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">OSLAM syndrome</a></div>
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||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_895927" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Paget disease of bone 3</a></div>
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||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_356468" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Premature aging syndrome, Okamoto type</a></div>
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||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_20552" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Retinoblastoma</a></div>
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||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1684753" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Rothmund-Thomson syndrome type 2</a></div>
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||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_12147" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Werner syndrome</a></div></span></div></div>
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</div>
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||
<div class="portlet mgSection" id="ID_105">
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||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Professional_guidelines">Professional guidelines</h1><a sid="105" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="portlet_content ln"><h3 class="subhead">PubMed<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpPM"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3>
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<div class="nl"><a target="_blank" href="/pubmed/34818481">New Horizons in the Treatment of Osteosarcoma.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Meltzer PS,
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Helman LJ</span><br />
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<span class="medgenPMjournal">N Engl J Med</span>
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2021 Nov 25;385(22):2066-2076.
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doi: 10.1056/NEJMra2103423.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34818481" target="_blank">34818481</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/33467756">Future Directions in the Treatment of Osteosarcoma.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Smrke A,
|
||
Anderson PM,
|
||
Gulia A,
|
||
Gennatas S,
|
||
Huang PH,
|
||
Jones RL</span><br />
|
||
<span class="medgenPMjournal">Cells</span>
|
||
2021 Jan 15;10(1)
|
||
doi: 10.3390/cells10010172.
|
||
<span class="bold">PMID: </span><a href="/pubmed/33467756" target="_blank">33467756</a><a href="/pmc/articles/PMC7829872" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/30215968">Bone Cancer: Diagnosis and Treatment Principles.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Ferguson JL,
|
||
Turner SP</span><br />
|
||
<span class="medgenPMjournal">Am Fam Physician</span>
|
||
2018 Aug 15;98(4):205-213.
|
||
<span class="bold">PMID: </span><a href="/pubmed/30215968" target="_blank">30215968</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(%22osteosarcoma%22%5Btiab%3A~0%5D)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">See all (841)</a></div><h3 class="subhead">Curated<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpCurated"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3><h3 class="nl vspace"><a href="https://www.nccn.org/professionals/physician_gls/pdf/bone.pdf" target="_blank">NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) Bone Cancer, 2024</a></h3>
|
||
</div>
|
||
</div>
|
||
<div class="display-none help-popup" id="guidelinesHelpPM">These guidelines are articles in PubMed that match specific search criteria developed by MedGen to capture the most relevant practice guidelines. This list may not be comprehensive and may include broader topics as well. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div><div class="display-none help-popup" id="guidelinesHelpCurated">These guidelines are manually curated by the MedGen team
|
||
to supplement articles available in PubMed. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div>
|
||
<div class="portlet mgSection" id="ID_103">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_clinical_studies">Recent clinical studies</h1><a sid="103" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">Etiology</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/36481668">Osteosarcoma.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Beird HC,
|
||
Bielack SS,
|
||
Flanagan AM,
|
||
Gill J,
|
||
Heymann D,
|
||
Janeway KA,
|
||
Livingston JA,
|
||
Roberts RD,
|
||
Strauss SJ,
|
||
Gorlick R</span><br />
|
||
<span class="medgenPMjournal">Nat Rev Dis Primers</span>
|
||
2022 Dec 8;8(1):77.
|
||
doi: 10.1038/s41572-022-00409-y.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36481668" target="_blank">36481668</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/32779875">Osteosarcoma.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Eaton BR,
|
||
Schwarz R,
|
||
Vatner R,
|
||
Yeh B,
|
||
Claude L,
|
||
Indelicato DJ,
|
||
Laack N</span><br />
|
||
<span class="medgenPMjournal">Pediatr Blood Cancer</span>
|
||
2021 May;68 Suppl 2:e28352.
|
||
Epub 2020 Aug 11
|
||
doi: 10.1002/pbc.28352.
|
||
<span class="bold">PMID: </span><a href="/pubmed/32779875" target="_blank">32779875</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/32400205">Epidemiology and Risk Factors of Osteosarcoma.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Sadykova LR,
|
||
Ntekim AI,
|
||
Muyangwa-Semenova M,
|
||
Rutland CS,
|
||
Jeyapalan JN,
|
||
Blatt N,
|
||
Rizvanov AA</span><br />
|
||
<span class="medgenPMjournal">Cancer Invest</span>
|
||
2020 May;38(5):259-269.
|
||
Epub 2020 Jun 1
|
||
doi: 10.1080/07357907.2020.1768401.
|
||
<span class="bold">PMID: </span><a href="/pubmed/32400205" target="_blank">32400205</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/20213383">The epidemiology of osteosarcoma.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Ottaviani G,
|
||
Jaffe N</span><br />
|
||
<span class="medgenPMjournal">Cancer Treat Res</span>
|
||
2009;152:3-13.
|
||
doi: 10.1007/978-1-4419-0284-9_1.
|
||
<span class="bold">PMID: </span><a href="/pubmed/20213383" target="_blank">20213383</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/7002283">Intracortical osteosarcoma.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Kyriakos M</span><br />
|
||
<span class="medgenPMjournal">Cancer</span>
|
||
1980 Dec 1;46(11):2525-33.
|
||
doi: 10.1002/1097-0142(19801201)46:11<2525::aid-cncr2820461135>3.0.co;2-#.
|
||
<span class="bold">PMID: </span><a href="/pubmed/7002283" target="_blank">7002283</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Osteosarcoma%22%20AND%20Etiology%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (6170)</a></div><h3 class="subhead">Diagnosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/35490205">Osteosarcoma/Ewing Sarcoma.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Self C,
|
||
MacQuarrie KL,
|
||
Cost CR</span><br />
|
||
<span class="medgenPMjournal">Pediatr Rev</span>
|
||
2022 May 1;43(5):256-265.
|
||
doi: 10.1542/pir.2021-005065.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35490205" target="_blank">35490205</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/34742481">Osteosarcoma: Old and New Challenges.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Yoshida A</span><br />
|
||
<span class="medgenPMjournal">Surg Pathol Clin</span>
|
||
2021 Dec;14(4):567-583.
|
||
Epub 2021 Oct 7
|
||
doi: 10.1016/j.path.2021.06.003.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34742481" target="_blank">34742481</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/25070231">Osteosarcoma.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Moore DD,
|
||
Luu HH</span><br />
|
||
<span class="medgenPMjournal">Cancer Treat Res</span>
|
||
2014;162:65-92.
|
||
doi: 10.1007/978-3-319-07323-1_4.
|
||
<span class="bold">PMID: </span><a href="/pubmed/25070231" target="_blank">25070231</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/9286295">Osteosarcoma.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Meyers PA,
|
||
Gorlick R</span><br />
|
||
<span class="medgenPMjournal">Pediatr Clin North Am</span>
|
||
1997 Aug;44(4):973-89.
|
||
doi: 10.1016/s0031-3955(05)70540-x.
|
||
<span class="bold">PMID: </span><a href="/pubmed/9286295" target="_blank">9286295</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/7002283">Intracortical osteosarcoma.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Kyriakos M</span><br />
|
||
<span class="medgenPMjournal">Cancer</span>
|
||
1980 Dec 1;46(11):2525-33.
|
||
doi: 10.1002/1097-0142(19801201)46:11<2525::aid-cncr2820461135>3.0.co;2-#.
|
||
<span class="bold">PMID: </span><a href="/pubmed/7002283" target="_blank">7002283</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Osteosarcoma%22%20AND%20Diagnosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (7681)</a></div><h3 class="subhead">Therapy</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/35190971">Systemic Therapy for Chondrosarcoma.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Rock A,
|
||
Ali S,
|
||
Chow WA</span><br />
|
||
<span class="medgenPMjournal">Curr Treat Options Oncol</span>
|
||
2022 Feb;23(2):199-209.
|
||
Epub 2022 Feb 21
|
||
doi: 10.1007/s11864-022-00951-7.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35190971" target="_blank">35190971</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/34131316">Advancing therapy for osteosarcoma.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Gill J,
|
||
Gorlick R</span><br />
|
||
<span class="medgenPMjournal">Nat Rev Clin Oncol</span>
|
||
2021 Oct;18(10):609-624.
|
||
Epub 2021 Jun 15
|
||
doi: 10.1038/s41571-021-00519-8.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34131316" target="_blank">34131316</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/33467756">Future Directions in the Treatment of Osteosarcoma.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Smrke A,
|
||
Anderson PM,
|
||
Gulia A,
|
||
Gennatas S,
|
||
Huang PH,
|
||
Jones RL</span><br />
|
||
<span class="medgenPMjournal">Cells</span>
|
||
2021 Jan 15;10(1)
|
||
doi: 10.3390/cells10010172.
|
||
<span class="bold">PMID: </span><a href="/pubmed/33467756" target="_blank">33467756</a><a href="/pmc/articles/PMC7829872" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/32016998">Effects of rapamycin on osteosarcoma cell proliferation and apoptosis by inducing autophagy.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Yu WX,
|
||
Lu C,
|
||
Wang B,
|
||
Ren XY,
|
||
Xu K</span><br />
|
||
<span class="medgenPMjournal">Eur Rev Med Pharmacol Sci</span>
|
||
2020 Jan;24(2):915-921.
|
||
doi: 10.26355/eurrev_202001_20076.
|
||
<span class="bold">PMID: </span><a href="/pubmed/32016998" target="_blank">32016998</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/26304877">Osteosarcoma: Current Treatment and a Collaborative Pathway to Success.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Isakoff MS,
|
||
Bielack SS,
|
||
Meltzer P,
|
||
Gorlick R</span><br />
|
||
<span class="medgenPMjournal">J Clin Oncol</span>
|
||
2015 Sep 20;33(27):3029-35.
|
||
Epub 2015 Aug 24
|
||
doi: 10.1200/JCO.2014.59.4895.
|
||
<span class="bold">PMID: </span><a href="/pubmed/26304877" target="_blank">26304877</a><a href="/pmc/articles/PMC4979196" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Osteosarcoma%22%20AND%20Therapy%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (5313)</a></div><h3 class="subhead">Prognosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/32779875">Osteosarcoma.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Eaton BR,
|
||
Schwarz R,
|
||
Vatner R,
|
||
Yeh B,
|
||
Claude L,
|
||
Indelicato DJ,
|
||
Laack N</span><br />
|
||
<span class="medgenPMjournal">Pediatr Blood Cancer</span>
|
||
2021 May;68 Suppl 2:e28352.
|
||
Epub 2020 Aug 11
|
||
doi: 10.1002/pbc.28352.
|
||
<span class="bold">PMID: </span><a href="/pubmed/32779875" target="_blank">32779875</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/32078813">Cabozantinib in patients with advanced Ewing sarcoma or osteosarcoma (CABONE): a multicentre, single-arm, phase 2 trial.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Italiano A,
|
||
Mir O,
|
||
Mathoulin-Pelissier S,
|
||
Penel N,
|
||
Piperno-Neumann S,
|
||
Bompas E,
|
||
Chevreau C,
|
||
Duffaud F,
|
||
Entz-Werlé N,
|
||
Saada E,
|
||
Ray-Coquard I,
|
||
Lervat C,
|
||
Gaspar N,
|
||
Marec-Berard P,
|
||
Pacquement H,
|
||
Wright J,
|
||
Toulmonde M,
|
||
Bessede A,
|
||
Crombe A,
|
||
Kind M,
|
||
Bellera C,
|
||
Blay JY</span><br />
|
||
<span class="medgenPMjournal">Lancet Oncol</span>
|
||
2020 Mar;21(3):446-455.
|
||
Epub 2020 Feb 17
|
||
doi: 10.1016/S1470-2045(19)30825-3.
|
||
<span class="bold">PMID: </span><a href="/pubmed/32078813" target="_blank">32078813</a><a href="/pmc/articles/PMC8763616" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/30685685">Survival and prognosis with osteosarcoma: outcomes in more than 2000 patients in the EURAMOS-1 (European and American Osteosarcoma Study) cohort.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Smeland S,
|
||
Bielack SS,
|
||
Whelan J,
|
||
Bernstein M,
|
||
Hogendoorn P,
|
||
Krailo MD,
|
||
Gorlick R,
|
||
Janeway KA,
|
||
Ingleby FC,
|
||
Anninga J,
|
||
Antal I,
|
||
Arndt C,
|
||
Brown KLB,
|
||
Butterfass-Bahloul T,
|
||
Calaminus G,
|
||
Capra M,
|
||
Dhooge C,
|
||
Eriksson M,
|
||
Flanagan AM,
|
||
Friedel G,
|
||
Gebhardt MC,
|
||
Gelderblom H,
|
||
Goldsby R,
|
||
Grier HE,
|
||
Grimer R,
|
||
Hawkins DS,
|
||
Hecker-Nolting S,
|
||
Sundby Hall K,
|
||
Isakoff MS,
|
||
Jovic G,
|
||
Kühne T,
|
||
Kager L,
|
||
von Kalle T,
|
||
Kabickova E,
|
||
Lang S,
|
||
Lau CC,
|
||
Leavey PJ,
|
||
Lessnick SL,
|
||
Mascarenhas L,
|
||
Mayer-Steinacker R,
|
||
Meyers PA,
|
||
Nagarajan R,
|
||
Randall RL,
|
||
Reichardt P,
|
||
Renard M,
|
||
Rechnitzer C,
|
||
Schwartz CL,
|
||
Strauss S,
|
||
Teot L,
|
||
Timmermann B,
|
||
Sydes MR,
|
||
Marina N</span><br />
|
||
<span class="medgenPMjournal">Eur J Cancer</span>
|
||
2019 Mar;109:36-50.
|
||
Epub 2019 Jan 25
|
||
doi: 10.1016/j.ejca.2018.11.027.
|
||
<span class="bold">PMID: </span><a href="/pubmed/30685685" target="_blank">30685685</a><a href="/pmc/articles/PMC6506906" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/27595362">Sarcomas of Soft Tissue and Bone.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Ferrari A,
|
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Dirksen U,
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Bielack S</span><br />
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<span class="medgenPMjournal">Prog Tumor Res</span>
|
||
2016;43:128-41.
|
||
Epub 2016 Sep 5
|
||
doi: 10.1159/000447083.
|
||
<span class="bold">PMID: </span><a href="/pubmed/27595362" target="_blank">27595362</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/12720206">Solid tumors in children.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Kline NE,
|
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Sevier N</span><br />
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<span class="medgenPMjournal">J Pediatr Nurs</span>
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2003 Apr;18(2):96-102.
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doi: 10.1053/jpdn.2003.12.
|
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<span class="bold">PMID: </span><a href="/pubmed/12720206" target="_blank">12720206</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Osteosarcoma%22%20AND%20Prognosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (7169)</a></div><h3 class="subhead">Clinical prediction guides</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/38629071">Single-cell RNA-seq reveals T cell exhaustion and immune response landscape in osteosarcoma.</a></div>
|
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<div class="portlet_content ln"><span class="medgenPMauthor">Fan Q,
|
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Wang Y,
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||
Cheng J,
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||
Pan B,
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||
Zang X,
|
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Liu R,
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||
Deng Y</span><br />
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<span class="medgenPMjournal">Front Immunol</span>
|
||
2024;15:1362970.
|
||
Epub 2024 Apr 2
|
||
doi: 10.3389/fimmu.2024.1362970.
|
||
<span class="bold">PMID: </span><a href="/pubmed/38629071" target="_blank">38629071</a><a href="/pmc/articles/PMC11018946" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/37055822">A tumor microenvironment-based prognostic index for osteosarcoma.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Wu C,
|
||
Gong S,
|
||
Duan Y,
|
||
Deng C,
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||
Kallendrusch S,
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Berninghausen L,
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Osterhoff G,
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2023 Apr 13;30(1):23.
|
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doi: 10.1186/s12929-023-00917-3.
|
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<span class="bold">PMID: </span><a href="/pubmed/37055822" target="_blank">37055822</a><a href="/pmc/articles/PMC10099847" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/36275664">Identification and characterization of aging/senescence-induced genes in osteosarcoma and predicting clinical prognosis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Lv Y,
|
||
Wu L,
|
||
Jian H,
|
||
Zhang C,
|
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Lou Y,
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Kang Y,
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Hou M,
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Li Z,
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Li X,
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Sun B,
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Zhou H</span><br />
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<span class="medgenPMjournal">Front Immunol</span>
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2022;13:997765.
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Epub 2022 Oct 5
|
||
doi: 10.3389/fimmu.2022.997765.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36275664" target="_blank">36275664</a><a href="/pmc/articles/PMC9579318" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/23466623">Osteosarcoma tumor thrombus: a case report with a review of the literature.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Navalkele P,
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||
Jones SM,
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Jones JK,
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Salazar JD,
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Toy PC,
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Iyer RV,
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Herrington B</span><br />
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<span class="medgenPMjournal">Tex Heart Inst J</span>
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||
2013;40(1):75-8.
|
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<span class="bold">PMID: </span><a href="/pubmed/23466623" target="_blank">23466623</a><a href="/pmc/articles/PMC3568289" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/11822072">Surgery for primary bone sarcomas of the pelvis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Somville J,
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Van Bouwel S</span><br />
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<span class="medgenPMjournal">Acta Orthop Belg</span>
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2001 Dec;67(5):442-7.
|
||
<span class="bold">PMID: </span><a href="/pubmed/11822072" target="_blank">11822072</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Osteosarcoma%22%20AND%20Clinical%20prediction%20guides%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (5952)</a></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_104">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_systematic_reviews">Recent systematic reviews</h1><a sid="104" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln">
|
||
<div class="nl"><a target="_blank" href="/pubmed/37232505">Association between genetically determined telomere length and health-related outcomes: A systematic review and meta-analysis of Mendelian randomization studies.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Chen B,
|
||
Yan Y,
|
||
Wang H,
|
||
Xu J</span><br />
|
||
<span class="medgenPMjournal">Aging Cell</span>
|
||
2023 Jul;22(7):e13874.
|
||
Epub 2023 May 26
|
||
doi: 10.1111/acel.13874.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37232505" target="_blank">37232505</a><a href="/pmc/articles/PMC10352568" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/35954639">Bone Infarcts and Tumorigenesis-Is There a Connection? A Mini-Mapping Review.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Konarski W,
|
||
Poboży T,
|
||
Hordowicz M,
|
||
Śliwczyński A,
|
||
Kotela I,
|
||
Krakowiak J,
|
||
Kotela A</span><br />
|
||
<span class="medgenPMjournal">Int J Environ Res Public Health</span>
|
||
2022 Jul 29;19(15)
|
||
doi: 10.3390/ijerph19159282.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35954639" target="_blank">35954639</a><a href="/pmc/articles/PMC9367991" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/35102626">Wogonin and its analogs for the prevention and treatment of cancer: A systematic review.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Banik K,
|
||
Khatoon E,
|
||
Harsha C,
|
||
Rana V,
|
||
Parama D,
|
||
Thakur KK,
|
||
Bishayee A,
|
||
Kunnumakkara AB</span><br />
|
||
<span class="medgenPMjournal">Phytother Res</span>
|
||
2022 May;36(5):1854-1883.
|
||
Epub 2022 Jan 31
|
||
doi: 10.1002/ptr.7386.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35102626" target="_blank">35102626</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/34981886">The role of toceranib phosphate in dogs with non-mast cell neoplasia: A systematic review.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Frezoulis P,
|
||
Harper A</span><br />
|
||
<span class="medgenPMjournal">Vet Comp Oncol</span>
|
||
2022 Jun;20(2):362-371.
|
||
Epub 2022 Jan 17
|
||
doi: 10.1111/vco.12799.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34981886" target="_blank">34981886</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/30251311">Blood-borne biomarkers of osteosarcoma: A systematic review.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Tan GJS,
|
||
Gerrand CH,
|
||
Rankin KS</span><br />
|
||
<span class="medgenPMjournal">Pediatr Blood Cancer</span>
|
||
2019 Jan;66(1):e27462.
|
||
Epub 2018 Sep 24
|
||
doi: 10.1002/pbc.27462.
|
||
<span class="bold">PMID: </span><a href="/pubmed/30251311" target="_blank">30251311</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Osteosarcoma%22%20AND%20systematic%5Bsb%5D%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (167)</a></div></div>
|
||
</div>
|
||
</div></div></div></div></div></div></div>
|
||
<div id="messagearea_bottom">
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|
||
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|
||
<div class=" bottom">
|
||
|
||
</div>
|
||
|
||
</div>
|
||
</div>
|
||
<div class="supplemental col three_col last">
|
||
<h2 class="offscreen_noflow">Supplemental Content</h2>
|
||
|
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|
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Table_of_contents">Table of contents</h1><a sid="113" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Genetic_Testing_Registry">Genetic Testing Registry</h1><a sid="106" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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||
<div class="portlet_content ln"><ul><li><a href="/gtr/tests?term=C0029463%5bDISCUI%5d&filter=method%3A2%5F8" target="_blank">Deletion/duplication analysis (13)</a></li>
|
||
<li><a href="/gtr/tests?term=C0029463%5bDISCUI%5d&filter=method%3A2%5F30" target="_blank">RNA analysis (2)</a></li>
|
||
<li><a href="/gtr/tests?term=C0029463%5bDISCUI%5d&filter=method%3A2%5F9" target="_blank">Sequence analysis of select exons (1)</a></li>
|
||
<li><a href="/gtr/tests?term=C0029463%5bDISCUI%5d&filter=method%3A2%5F7" target="_blank">Sequence analysis of the entire coding region (15)</a></li>
|
||
<li><a href="/gtr/tests?term=C0029463%5bDISCUI%5d&filter=method%3A2%5F19" target="_blank">Targeted variant analysis (2)</a></li>
|
||
<li class="portletSeeAll portletSeeAllPad"><total><a href="/gtr/tests?term=C0029463%5bDISCUI%5d" target="_blank">See all (17)</a></total></li>
|
||
</ul></div>
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Clinical_resources">Clinical resources</h1><a sid="119" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="portlet_content ln"><ul><li><a href="https://clinicaltrials.gov/search?cond=Osteosarcoma" target="_blank">ClinicalTrials.gov</a></li></ul></div>
|
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|
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Practice_guidelines">Practice guidelines</h1><a sid="121" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="portlet_content ln"><ul class="a_poppers"><li><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(%22osteosarcoma%22%5Btiab%3A~0%5D)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">PubMed</a><div class="help-popup">See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div></li><li><a target="_blank" href="/books/?term=((%22clinical%20guidelines%22%5BResource%20Type%5D)%20OR%20%22practice%20guideline%22%5BPublication%20Type%5D)%20AND%20(%22Osteosarcoma%22)">Bookshelf</a><div class="help-popup">See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div></li></ul><h3 class="subhead">Curated</h3><ul class="a_poppers"><li><a target="_blank" href="https://www.nccn.org/professionals/physician_gls/pdf/bone.pdf">NCCN, 2024</a><div>NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) Bone Cancer, 2024</div></li></ul></div>
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||
<div class="portlet_content ln"><ul><li><a href="http://www.diseaseinfosearch.org/Osteosarcoma/5489" target="_blank">Genetic Alliance</a></li><li><a href="https://www.malacards.org/card/osteogenic_sarcoma" target="_blank">MalaCards</a></li><li><a href="https://vsearch.nlm.nih.gov/vivisimo/cgi-bin/query-meta?v:project=medlineplus&query=Osteosarcoma" target="_blank">MedlinePlus</a></li></ul></div>
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<li>
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<a href="/pubmed/clinical?term=Osteosarcoma" ref="ncbi_uid=&discoId=gtr_reviews&linkpos=1&linkpostotal=2" target="_blank">PubMed Clinical Queries</a>
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</li>
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<li>
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<a href="/pubmed?term=Osteosarcoma%20AND%20humans[mesh]%20AND%20review[publication%20type]" ref="ncbi_uid=&discoId=gtr_reviews&linkpos=2&linkpostotal=2" target="_blank">Reviews in PubMed</a>
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<h3>Related information</h3>
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<a class="brieflinkpopperctrl" href="/clinvar?LinkName=medgen_clinvar&from_uid=10501" ref="log$=recordlinks">ClinVar</a>
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<div class="brieflinkpop offscreen_noflow">Related medical variations</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/gtr/tests?term=C0029463[DISCUI]" ref="log$=recordlinks">GTR</a>
|
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<div class="brieflinkpop offscreen_noflow">Related information in GTR</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/gtr/tests?term=C0029463[DISCUI]&test_type=Clinical" ref="log$=recordlinks">GTR(Clinical)</a>
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<div class="brieflinkpop offscreen_noflow">Clinical tests in GTR</div>
|
||
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|
||
<li class="brieflinkpopper">
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||
<a class="brieflinkpopperctrl" href="/mesh?LinkName=medgen_mesh&from_uid=10501" ref="log$=recordlinks">MeSH</a>
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<div class="brieflinkpop offscreen_noflow">Related Medical Subject Headings</div>
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<li class="brieflinkpopper">
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