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<meta name="robots" content="INDEX,FOLLOW,NOARCHIVE" /><meta name="citation_inbook_title" content="Webvision: The Organization of the Retina and Visual System [Internet]" /><meta name="citation_title" content="Age-Related Macular Degeneration (AMD)" /><meta name="citation_publisher" content="University of Utah Health Sciences Center" /><meta name="citation_date" content="2008/01/01" /><meta name="citation_author" content="Gregory S. Hageman" /><meta name="citation_author" content="Karen Gehrs" /><meta name="citation_author" content="Lincoln V. Johnson" /><meta name="citation_author" content="Don Anderson" /><meta name="citation_pmid" content="21413412" /><meta name="citation_fulltext_html_url" content="https://www.ncbi.nlm.nih.gov/books/NBK27323/" /><link rel="schema.DC" href="http://purl.org/DC/elements/1.0/" /><meta name="DC.Title" content="Age-Related Macular Degeneration (AMD)" /><meta name="DC.Type" content="Text" /><meta name="DC.Publisher" content="University of Utah Health Sciences Center" /><meta name="DC.Contributor" content="Gregory S. Hageman" /><meta name="DC.Contributor" content="Karen Gehrs" /><meta name="DC.Contributor" content="Lincoln V. 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Although the macula comprises only four percent of retinal area, it is responsible for the majority of useful photopic vision. The fovea lies at the center of the macula (Fig. 1, asterisk) and is approximately 2mm in diameter. The fovea is particularly well seen in vertical section view using ocular coherence tomography techniques in living eyes (Fig. 2). The fovea contains the highest density of cone photoreceptor cells and is the only region of the retina where 20/20 vision is attainable. The macula accounts for almost 10% of the entire visual field. 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<div class="pre-content"><div><div class="bk_prnt"><p class="small">NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.</p><p>Kolb H, Fernandez E, Jones B, et al., editors. Webvision: The Organization of the Retina and Visual System [Internet]. Salt Lake City (UT): University of Utah Health Sciences Center; 1995-. </p></div><div class="iconblock clearfix whole_rhythm no_top_margin bk_noprnt"><a class="img_link icnblk_img" title="Table of Contents Page" href="/books/n/webvision/"><img class="source-thumb" src="/corehtml/pmc/pmcgifs/bookshelf/thumbs/th-webvision-lrg.png" alt="Cover of Webvision" height="100px" width="80px" /></a><div class="icnblk_cntnt eight_col"><h2>Webvision: The Organization of the Retina and Visual System [Internet].</h2><a data-jig="ncbitoggler" href="#__NBK27323_dtls__">Show details</a><div style="display:none" class="ui-widget" id="__NBK27323_dtls__"><div>Kolb H, Fernandez E, Jones B, et al., editors.</div><div>Salt Lake City (UT): <a href="http://webvision.med.utah.edu/" ref="pagearea=page-banner&targetsite=external&targetcat=link&targettype=publisher">University of Utah Health Sciences Center</a>; 1995-.</div></div><div class="half_rhythm"><ul class="inline_list"><li style="margin-right:1em"><a class="bk_cntns" href="/books/n/webvision/">Contents</a></li></ul></div><div class="bk_noprnt"><form method="get" action="/books/n/webvision/" id="bk_srch"><div class="bk_search"><label for="bk_term" class="offscreen_noflow">Search term</label><input type="text" title="Search this book" id="bk_term" name="term" value="" data-jig="ncbiclearbutton" /> <input type="submit" class="jig-ncbibutton" value="Search this book" submit="false" style="padding: 0.1em 0.4em;" /></div></form></div></div><div class="icnblk_cntnt two_col"><div class="pagination bk_noprnt"><a class="active page_link prev" href="/books/n/webvision/ch37fisher/" title="Previous page in this title">< Prev</a><a class="active page_link next" href="/books/n/webvision/ArdenRetinopathy/" title="Next page in this title">Next ></a></div></div></div></div></div>
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<div class="main-content lit-style" itemscope="itemscope" itemtype="http://schema.org/CreativeWork"><div class="meta-content fm-sec"><h1 id="_NBK27323_"><span class="title" itemprop="name">Age-Related Macular Degeneration (AMD)</span></h1><p class="contrib-group"><span itemprop="author">Gregory S. Hageman</span>, <span itemprop="author">Karen Gehrs</span>, <span itemprop="author">Lincoln V. Johnson</span>, and <span itemprop="author">Don Anderson</span>.</p><p class="small">Created: <span itemprop="datePublished">January 1, 2008</span>.</p></div><div class="jig-ncbiinpagenav body-content whole_rhythm" data-jigconfig="allHeadingLevels: ['h2'],smoothScroll: false" itemprop="text"><div id="ch38macular.Introduction"><h2 id="_ch38macular_Introduction_">Introduction</h2><p>Age-related macular degeneration (AMD), the leading cause of worldwide blindness in the elderly, is a bilateral ocular condition that affects the central area of retina known as the macula. The macula lutea, which derives its name from the deposition of yellow xanthophyll pigments (<a href="/books/n/webvision/A34/">see chapter on simple anatomy</a>), is located temporal to the optic disc and is bounded by the temporal superior and inferior vascular arcades (<a class="figpopup" href="/books/NBK27323/figure/ch38macular.F1/?report=objectonly" target="object" rid-figpopup="figch38macularF1" rid-ob="figobch38macularF1">Fig. 1</a>). Although the macula comprises only four percent of retinal area, it is responsible for the majority of useful photopic vision. The fovea lies at the center of the macula (<a class="figpopup" href="/books/NBK27323/figure/ch38macular.F1/?report=objectonly" target="object" rid-figpopup="figch38macularF1" rid-ob="figobch38macularF1">Fig. 1, asterisk</a>) and is approximately 2mm in diameter. The fovea is particularly well seen in vertical section view using ocular coherence tomography techniques in living eyes (<a class="figpopup" href="/books/NBK27323/figure/ch38macular.F2/?report=objectonly" target="object" rid-figpopup="figch38macularF2" rid-ob="figobch38macularF2">Fig. 2</a>). The fovea contains the highest density of cone photoreceptor cells and is the only region of the retina where 20/20 vision is attainable. The macula accounts for almost 10% of the entire visual field. Thus, lesions developing in this region can have a major impact on visual function.</p><div class="iconblock whole_rhythm clearfix ten_col fig" id="figch38macularF1" co-legend-rid="figlgndch38macularF1"><a href="/books/NBK27323/figure/ch38macular.F1/?report=objectonly" target="object" title="Figure 1. " class="img_link icnblk_img figpopup" rid-figpopup="figch38macularF1" rid-ob="figobch38macularF1"><img class="small-thumb" src="/books/NBK27323/bin/ch38macular-Image002.gif" src-large="/books/NBK27323/bin/ch38macular-Image002.jpg" alt="Figure 1. . Normal macula of an elderly patient." /></a><div class="icnblk_cntnt" id="figlgndch38macularF1"><h4 id="ch38macular.F1"><a href="/books/NBK27323/figure/ch38macular.F1/?report=objectonly" target="object" rid-ob="figobch38macularF1">Figure 1. </a></h4><p class="float-caption no_bottom_margin">Normal macula of an elderly patient. The asterisk represents the location of the fovea, which lies directly in the visual axis. The macula (boxed area), which is adapted for high acuity vision, is located temporal to the optic nerve (arrow). It is approximately <a href="/books/NBK27323/figure/ch38macular.F1/?report=objectonly" target="object" rid-ob="figobch38macularF1">(more...)</a></p></div></div><div class="iconblock whole_rhythm clearfix ten_col fig" id="figch38macularF2" co-legend-rid="figlgndch38macularF2"><a href="/books/NBK27323/figure/ch38macular.F2/?report=objectonly" target="object" title="Figure 2. " class="img_link icnblk_img figpopup" rid-figpopup="figch38macularF2" rid-ob="figobch38macularF2"><img class="small-thumb" src="/books/NBK27323/bin/ch38macular-Image003.gif" src-large="/books/NBK27323/bin/ch38macular-Image003.jpg" alt="Figure 2. . Ocular coherence tomogram (OCT) of a normal macula." /></a><div class="icnblk_cntnt" id="figlgndch38macularF2"><h4 id="ch38macular.F2"><a href="/books/NBK27323/figure/ch38macular.F2/?report=objectonly" target="object" rid-ob="figobch38macularF2">Figure 2. </a></h4><p class="float-caption no_bottom_margin">Ocular coherence tomogram (OCT) of a normal macula. The central area of depression (arrow) represents the fovea, corresponding to the asterisk in Figure 1. Ret, retina. </p></div></div><p>AMD has a tremendous impact on the physical and mental health of the geriatric population and their families. Prior to 1990, AMD of all forms was often referred to as "senile macular degeneration" or SMD, a reflection of the fact that the vision loss associated with AMD manifests late in life when most affected individuals are looking forward to enjoying retirement activities and maintaining independence. Instead, millions with AMD suffer bilateral central vision loss such that they can no longer drive, read a newspaper, prepare meals, or enjoy recreational activities. For many patients, the visual impairment associated with AMD means a loss of independence, depression, increased financial concerns and the need to adapt to vision loss at a time when they are likely suffering from other debilitating conditions (<a class="bk_pop" href="#ch38macular.REF.1" data-bk-pop-others="ch38macular.REF.2 ch38macular.REF.3 ch38macular.REF.4 ch38macular.REF.5">1-5</a>).</p><p>The cost to society is only now being appreciated. A recent analysis of AMD in Australia predicts that the disease costs $2.6 billion per year (<a class="bk_pop" href="#ch38macular.REF.6">6</a>). This is projected to grow to $6.5 billion by 2025, a total cost of $59 billion over the next 20 years. A treatment that reduced the progression by only 10% would save Australia $5.7 billion over that same period of time. Similar analyses for the United States are lacking, but given the demographics and higher cost of medical care in the US, the costs would be projected to as much as twenty-fold higher.</p><p>Clinically, AMD is classified into the nonexudative "dry" or atrophic form and the exudative "wet" or neovascular form. More severe vision loss is typically associated with the "wet" form that occurs in about 15% of all patients with AMD but up to 20% of legal blindness from AMD is due to the "dry" form (<a class="bk_pop" href="#ch38macular.REF.7">7</a>).</p></div><div id="ch38macular.Clinical_Aspects_of_AMD"><h2 id="_ch38macular_Clinical_Aspects_of_AMD_">Clinical Aspects of AMD</h2><div id="ch38macular.Clinical_Presentation_of_AMD"><h3>Clinical Presentation of AMD</h3><p>Although autopsy studies have documented histological and ultrastructural changes associated with AMD in the retina, retinal pigment epithelium (RPE), choriorcapillaris and choroid in middle age, the disease typically does not manifest clinically before age 55 (<a class="bk_pop" href="#ch38macular.REF.10">10</a>). AMD is generally thought to progress along a continuum from atrophic or "dry" AMD (<a class="figpopup" href="/books/NBK27323/figure/ch38macular.F3/?report=objectonly" target="object" rid-figpopup="figch38macularF3" rid-ob="figobch38macularF3">Figs. 3</a> and <a class="figpopup" href="/books/NBK27323/figure/ch38macular.F4/?report=objectonly" target="object" rid-figpopup="figch38macularF4" rid-ob="figobch38macularF4">4</a>) to neovascular "wet" AMD with approximately 10% - 15% of all AMD patients eventually developing the wet form. Occasionally patients with no prior signs of dry AMD present with exudative changes as the first manifestation of the condition. The typical clinical sign of "dry" AMD is pigment disruption and drusen (small yellowish deposits in <a class="figpopup" href="/books/NBK27323/figure/ch38macular.F3/?report=objectonly" target="object" rid-figpopup="figch38macularF3" rid-ob="figobch38macularF3">Figs. 3</a><a class="figpopup" href="/books/NBK27323/figure/ch38macular.F4/?report=objectonly" target="object" rid-figpopup="figch38macularF4" rid-ob="figobch38macularF4">maculardegen.F4</a><a class="figpopup" href="/books/NBK27323/figure/ch38macular.F5/?report=objectonly" target="object" rid-figpopup="figch38macularF5" rid-ob="figobch38macularF5">maculardegen.F5</a>-<a class="figpopup" href="/books/NBK27323/figure/ch38macular.F6/?report=objectonly" target="object" rid-figpopup="figch38macularF6" rid-ob="figobch38macularF6">6</a>) in the retina. Drusen may be small "hard" (small with discrete margins) or "soft" (larger with indistinct edges) (<a class="figpopup" href="/books/NBK27323/figure/ch38macular.F3/?report=objectonly" target="object" rid-figpopup="figch38macularF3" rid-ob="figobch38macularF3">Figs. 3</a>-<a class="figpopup" href="/books/NBK27323/figure/ch38macular.F4/?report=objectonly" target="object" rid-figpopup="figch38macularF4" rid-ob="figobch38macularF4">maculardegen.F4</a><a class="figpopup" href="/books/NBK27323/figure/ch38macular.F5/?report=objectonly" target="object" rid-figpopup="figch38macularF5" rid-ob="figobch38macularF5">maculardegen.F5</a><a class="figpopup" href="/books/NBK27323/figure/ch38macular.F6/?report=objectonly" target="object" rid-figpopup="figch38macularF6" rid-ob="figobch38macularF6">6</a>). They lie between the RPE and an adjacent basement membrane complex known as Bruch's membrane (BM) (See later <a class="figpopup" href="/books/NBK27323/figure/ch38macular.F13/?report=objectonly" target="object" rid-figpopup="figch38macularF13" rid-ob="figobch38macularF13">Figs. 13</a>-<a class="figpopup" href="/books/NBK27323/figure/ch38macular.F14/?report=objectonly" target="object" rid-figpopup="figch38macularF14" rid-ob="figobch38macularF14">maculardegen.F14</a><a class="figpopup" href="/books/NBK27323/figure/ch38macular.F15/?report=objectonly" target="object" rid-figpopup="figch38macularF15" rid-ob="figobch38macularF15">maculardegen.F15</a><a class="figpopup" href="/books/NBK27323/figure/ch38macular.F16/?report=objectonly" target="object" rid-figpopup="figch38macularF16" rid-ob="figobch38macularF16">16</a>). Geographic atrophy (GA) and RPE changes are also observed in dry AMD (<a class="figpopup" href="/books/NBK27323/figure/ch38macular.F7/?report=objectonly" target="object" rid-figpopup="figch38macularF7" rid-ob="figobch38macularF7">Fig. 7</a>). Several classification schemes have been developed that subdivide dry AMD into categories based on the number and size of drusen, amount of GA, and degree of pigmentary changes in the macula (<a class="bk_pop" href="#ch38macular.REF.25" data-bk-pop-others="ch38macular.REF.26 ch38macular.REF.27 ch38macular.REF.28">25-28</a>).</p><div class="iconblock whole_rhythm clearfix ten_col fig" id="figch38macularF3" co-legend-rid="figlgndch38macularF3"><a href="/books/NBK27323/figure/ch38macular.F3/?report=objectonly" target="object" title="Figure 3. " class="img_link icnblk_img figpopup" rid-figpopup="figch38macularF3" rid-ob="figobch38macularF3"><img class="small-thumb" src="/books/NBK27323/bin/ch38macular-Image004.gif" src-large="/books/NBK27323/bin/ch38macular-Image004.jpg" alt="Figure 3. . Color fundus photograph derived from an individual with early, dry AMD." /></a><div class="icnblk_cntnt" id="figlgndch38macularF3"><h4 id="ch38macular.F3"><a href="/books/NBK27323/figure/ch38macular.F3/?report=objectonly" target="object" rid-ob="figobch38macularF3">Figure 3. </a></h4><p class="float-caption no_bottom_margin">Color fundus photograph derived from an individual with early, dry AMD. RPE pigment disruption is present in the macula (arrow) and numerous small (< 63 microns in diameter) hard drusen are present inferior to this region (oval). </p></div></div><div class="iconblock whole_rhythm clearfix ten_col fig" id="figch38macularF4" co-legend-rid="figlgndch38macularF4"><a href="/books/NBK27323/figure/ch38macular.F4/?report=objectonly" target="object" title="Figure 4. " class="img_link icnblk_img figpopup" rid-figpopup="figch38macularF4" rid-ob="figobch38macularF4"><img class="small-thumb" src="/books/NBK27323/bin/ch38macular-Image005.gif" src-large="/books/NBK27323/bin/ch38macular-Image005.jpg" alt="Figure 4. . Color fundus photograph from an individual with dry AMD." /></a><div class="icnblk_cntnt" id="figlgndch38macularF4"><h4 id="ch38macular.F4"><a href="/books/NBK27323/figure/ch38macular.F4/?report=objectonly" target="object" rid-ob="figobch38macularF4">Figure 4. </a></h4><p class="float-caption no_bottom_margin">Color fundus photograph from an individual with dry AMD. Numerous small and intermediate-sized drusen are visible in the macular region (oval). </p></div></div><div class="iconblock whole_rhythm clearfix ten_col fig" id="figch38macularF5" co-legend-rid="figlgndch38macularF5"><a href="/books/NBK27323/figure/ch38macular.F5/?report=objectonly" target="object" title="Figure 5. " class="img_link icnblk_img figpopup" rid-figpopup="figch38macularF5" rid-ob="figobch38macularF5"><img class="small-thumb" src="/books/NBK27323/bin/ch38macular-Image006.gif" src-large="/books/NBK27323/bin/ch38macular-Image006.jpg" alt="Figure 5. . Corresponding fluorescein angiogram (a) and color fundus photograph (b) images from an individual with dry AMD." /></a><div class="icnblk_cntnt" id="figlgndch38macularF5"><h4 id="ch38macular.F5"><a href="/books/NBK27323/figure/ch38macular.F5/?report=objectonly" target="object" rid-ob="figobch38macularF5">Figure 5. </a></h4><p class="float-caption no_bottom_margin">Corresponding fluorescein angiogram (a) and color fundus photograph (b) images from an individual with dry AMD. Although larger and confluent drusen are visible in the color image (circle), the number and extent of drusen distribution is appreciated even <a href="/books/NBK27323/figure/ch38macular.F5/?report=objectonly" target="object" rid-ob="figobch38macularF5">(more...)</a></p></div></div><div class="iconblock whole_rhythm clearfix ten_col fig" id="figch38macularF6" co-legend-rid="figlgndch38macularF6"><a href="/books/NBK27323/figure/ch38macular.F6/?report=objectonly" target="object" title="Figure 6. " class="img_link icnblk_img figpopup" rid-figpopup="figch38macularF6" rid-ob="figobch38macularF6"><img class="small-thumb" src="/books/NBK27323/bin/ch38macular-Image007.gif" src-large="/books/NBK27323/bin/ch38macular-Image007.jpg" alt="Figure 6. . Color fundus photograph from an individual with dry AMD, depicting the presence of numerous large (>125 micron diameter), calcified drusen deposited primarily within the peri- and parafoveal regions." /></a><div class="icnblk_cntnt" id="figlgndch38macularF6"><h4 id="ch38macular.F6"><a href="/books/NBK27323/figure/ch38macular.F6/?report=objectonly" target="object" rid-ob="figobch38macularF6">Figure 6. </a></h4><p class="float-caption no_bottom_margin">Color fundus photograph from an individual with dry AMD, depicting the presence of numerous large (>125 micron diameter), calcified drusen deposited primarily within the peri- and parafoveal regions. Smaller drusen are present in the foveal region <a href="/books/NBK27323/figure/ch38macular.F6/?report=objectonly" target="object" rid-ob="figobch38macularF6">(more...)</a></p></div></div><div class="iconblock whole_rhythm clearfix ten_col fig" id="figch38macularF13" co-legend-rid="figlgndch38macularF13"><a href="/books/NBK27323/figure/ch38macular.F13/?report=objectonly" target="object" title="Figure 13. " class="img_link icnblk_img figpopup" rid-figpopup="figch38macularF13" rid-ob="figobch38macularF13"><img class="small-thumb" src="/books/NBK27323/bin/ch38macular-Image014.gif" src-large="/books/NBK27323/bin/ch38macular-Image014.jpg" alt="Figure 13. . Schematic images depicting the choroid-RPE-retina interface in a normal retina and an AMD interface." /></a><div class="icnblk_cntnt" id="figlgndch38macularF13"><h4 id="ch38macular.F13"><a href="/books/NBK27323/figure/ch38macular.F13/?report=objectonly" target="object" rid-ob="figobch38macularF13">Figure 13. </a></h4><p class="float-caption no_bottom_margin">Schematic images depicting the choroid-RPE-retina interface in a normal retina and an AMD interface. The choriocapillaris-RPE interface in unaffected (top) and affected (bottom). The majority of early AMD-associated extracellular lesions - including drusen, <a href="/books/NBK27323/figure/ch38macular.F13/?report=objectonly" target="object" rid-ob="figobch38macularF13">(more...)</a></p></div></div><div class="iconblock whole_rhythm clearfix ten_col fig" id="figch38macularF14" co-legend-rid="figlgndch38macularF14"><a href="/books/NBK27323/figure/ch38macular.F14/?report=objectonly" target="object" title="Figure 14. " class="img_link icnblk_img figpopup" rid-figpopup="figch38macularF14" rid-ob="figobch38macularF14"><img class="small-thumb" src="/books/NBK27323/bin/ch38macular-Image015.gif" src-large="/books/NBK27323/bin/ch38macular-Image015.jpg" alt="Figure 14. . Histological section shows drusen (asterisks) forming between the RPE and Bruch's membrane in an early AMD case." /></a><div class="icnblk_cntnt" id="figlgndch38macularF14"><h4 id="ch38macular.F14"><a href="/books/NBK27323/figure/ch38macular.F14/?report=objectonly" target="object" rid-ob="figobch38macularF14">Figure 14. </a></h4><p class="float-caption no_bottom_margin">Histological section shows drusen (asterisks) forming between the RPE and Bruch's membrane in an early AMD case. </p></div></div><div class="iconblock whole_rhythm clearfix ten_col fig" id="figch38macularF15" co-legend-rid="figlgndch38macularF15"><a href="/books/NBK27323/figure/ch38macular.F15/?report=objectonly" target="object" title="Figure 15. " class="img_link icnblk_img figpopup" rid-figpopup="figch38macularF15" rid-ob="figobch38macularF15"><img class="small-thumb" src="/books/NBK27323/bin/ch38macular-Image016.gif" src-large="/books/NBK27323/bin/ch38macular-Image016.jpg" alt="Figure 15. . Drusen (asterisks), form between the RPE and Bruch's membrane." /></a><div class="icnblk_cntnt" id="figlgndch38macularF15"><h4 id="ch38macular.F15"><a href="/books/NBK27323/figure/ch38macular.F15/?report=objectonly" target="object" rid-ob="figobch38macularF15">Figure 15. </a></h4><p class="float-caption no_bottom_margin">Drusen (asterisks), form between the RPE and Bruch's membrane. </p></div></div><div class="iconblock whole_rhythm clearfix ten_col fig" id="figch38macularF16" co-legend-rid="figlgndch38macularF16"><a href="/books/NBK27323/figure/ch38macular.F16/?report=objectonly" target="object" title="Figure 16. " class="img_link icnblk_img figpopup" rid-figpopup="figch38macularF16" rid-ob="figobch38macularF16"><img class="small-thumb" src="/books/NBK27323/bin/ch38macular-Image017.gif" src-large="/books/NBK27323/bin/ch38macular-Image017.jpg" alt="Figure 16. . Extensive accumulation of BLamD (asterisks) is also commom between the RPE and Bruch's membrane." /></a><div class="icnblk_cntnt" id="figlgndch38macularF16"><h4 id="ch38macular.F16"><a href="/books/NBK27323/figure/ch38macular.F16/?report=objectonly" target="object" rid-ob="figobch38macularF16">Figure 16. </a></h4><p class="float-caption no_bottom_margin">Extensive accumulation of BLamD (asterisks) is also commom between the RPE and Bruch's membrane. </p></div></div><div class="iconblock whole_rhythm clearfix ten_col fig" id="figch38macularF7" co-legend-rid="figlgndch38macularF7"><a href="/books/NBK27323/figure/ch38macular.F7/?report=objectonly" target="object" title="Figure 7. " class="img_link icnblk_img figpopup" rid-figpopup="figch38macularF7" rid-ob="figobch38macularF7"><img class="small-thumb" src="/books/NBK27323/bin/ch38macular-Image008.gif" src-large="/books/NBK27323/bin/ch38macular-Image008.jpg" alt="Figure 7. . Color fundus photograph from two patients (a and b) with macular geographic atrophy (GA)." /></a><div class="icnblk_cntnt" id="figlgndch38macularF7"><h4 id="ch38macular.F7"><a href="/books/NBK27323/figure/ch38macular.F7/?report=objectonly" target="object" rid-ob="figobch38macularF7">Figure 7. </a></h4><p class="float-caption no_bottom_margin">Color fundus photograph from two patients (a and b) with macular geographic atrophy (GA). The margins of the regions of RPE atrophy are clearly delineated (arrowheads). Choroidal blood vessels (arrows) are more easily visualized in these regions of atrophy <a href="/books/NBK27323/figure/ch38macular.F7/?report=objectonly" target="object" rid-ob="figobch38macularF7">(more...)</a></p></div></div><p>Angiography using sodium fluorescein dye is commonly performed when signs of AMD are observed and and particularly when exudative changes are suspected.</p><p>The natural history of dry AMD is progressive, with gradual loss of visual function that may span over many years time. Many patients with dry AMD are asymptomatic and unaware of the disease. In 10-15% percent of patients with dry AMD the deterioration is more rapid and extensive and they suffer significant vision loss due to geographic atrophy.</p><p>In approximately 10-15% of patients the condition progresses to the "wet" or neovascular form. Left untreated, the natural history of wet AMD advances further to a cicatrical stage referred to as a disciform scar. This process usually takes place over several months and typically results in a 4-8 mm diameter fibrotic scar underlying the macula accompanied by a central scotoma with severe central vision loss in one eye (<a class="figpopup" href="/books/NBK27323/figure/ch38macular.F11/?report=objectonly" target="object" rid-figpopup="figch38macularF11" rid-ob="figobch38macularF11">Fig. 11</a>). Patients with neovascular AMD in one eye have a 4 - 12% per year cumulative risk of developing neovascular AMD in the fellow eye. Thus, the risk of bilateral loss of central vision is high in those with the neovascular form of the disease (<a class="bk_pop" href="#ch38macular.REF.30">30</a>).</p><div class="iconblock whole_rhythm clearfix ten_col fig" id="figch38macularF11" co-legend-rid="figlgndch38macularF11"><a href="/books/NBK27323/figure/ch38macular.F11/?report=objectonly" target="object" title="Figure 11. " class="img_link icnblk_img figpopup" rid-figpopup="figch38macularF11" rid-ob="figobch38macularF11"><img class="small-thumb" src="/books/NBK27323/bin/ch38macular-Image012.gif" src-large="/books/NBK27323/bin/ch38macular-Image012.jpg" alt="Figure 11. . Color fundus photograph from an individual with end stage (cicatricial) exudative AMD." /></a><div class="icnblk_cntnt" id="figlgndch38macularF11"><h4 id="ch38macular.F11"><a href="/books/NBK27323/figure/ch38macular.F11/?report=objectonly" target="object" rid-ob="figobch38macularF11">Figure 11. </a></h4><p class="float-caption no_bottom_margin">Color fundus photograph from an individual with end stage (cicatricial) exudative AMD. A large disciform scar (arrowhead) covering the macular region is distinctly visible. </p></div></div><p>The designation of exudative or "wet" AMD implies that fluid, exudates and/or blood are present in the extracellular space between the neural retina and the RPE (i.e. the subretinal space) and/or, as in the case of RPE detachments, between the RPE and Bruch's membrane (i.e. the sub-RPE space).</p><p>The neovascular tissue associated with exudative AMD is most commonly referred to as choroidal neovascularization (CNV) because it originates from the normal choriorcapillaris and extends through a dehiscence in Bruch's membrane into the subretinal or sub-RPE space. Sometimes multiple soft drusen become confluent and create large pigment epithelial detachments (PED's), which represent an elevation of the retinal pigment epithelium under the retina (<a class="figpopup" href="/books/NBK27323/figure/ch38macular.F10/?report=objectonly" target="object" rid-figpopup="figch38macularF10" rid-ob="figobch38macularF10">Fig.10</a>). Neovascularization associated with PEDs can be difficult to visualize clinically or image using fluorescein angiography; therefore, it is difficult to treat (<a class="bk_pop" href="#ch38macular.REF.29">29</a>).</p><div class="iconblock whole_rhythm clearfix ten_col fig" id="figch38macularF10" co-legend-rid="figlgndch38macularF10"><a href="/books/NBK27323/figure/ch38macular.F10/?report=objectonly" target="object" title="Figure 10. " class="img_link icnblk_img figpopup" rid-figpopup="figch38macularF10" rid-ob="figobch38macularF10"><img class="small-thumb" src="/books/NBK27323/bin/ch38macular-Image011.gif" src-large="/books/NBK27323/bin/ch38macular-Image011.jpg" alt="Figure 10. . Corresponding angiographic (a) and OCT images (b) from an individual with a macular pigment epithelial detachment (PED)." /></a><div class="icnblk_cntnt" id="figlgndch38macularF10"><h4 id="ch38macular.F10"><a href="/books/NBK27323/figure/ch38macular.F10/?report=objectonly" target="object" rid-ob="figobch38macularF10">Figure 10. </a></h4><p class="float-caption no_bottom_margin">Corresponding angiographic (a) and OCT images (b) from an individual with a macular pigment epithelial detachment (PED). A multilobulated, hyperfluorescent lesion with sharply demarcated borders (arrow) is clearly visible in a 16. The blister-like elevation <a href="/books/NBK27323/figure/ch38macular.F10/?report=objectonly" target="object" rid-ob="figobch38macularF10">(more...)</a></p></div></div><p>The following figures show pictures of different patients' retinas with advanced cases of AMD of the wet form. <a class="figpopup" href="/books/NBK27323/figure/ch38macular.F8/?report=objectonly" target="object" rid-figpopup="figch38macularF8" rid-ob="figobch38macularF8">Fig. 8</a> shows a color fundus picture (a) and an early (b) and late fluorescein angiogram (c) from an individual with a classic choroidal neovascularization (CNV). Subretinal blood and fluid (arrowhead depicts edge) is clearly visible within the macular region in (a). The blood vessels have a lacey appearance (asterisk) in the early angiogram. Marked leakage of fluorescein (asterisk), with indistinct edges of hyperfluorescence (white area) is clearly visible in the late angiogram.</p><div class="iconblock whole_rhythm clearfix ten_col fig" id="figch38macularF8" co-legend-rid="figlgndch38macularF8"><a href="/books/NBK27323/figure/ch38macular.F8/?report=objectonly" target="object" title="Figure 8. " class="img_link icnblk_img figpopup" rid-figpopup="figch38macularF8" rid-ob="figobch38macularF8"><img class="small-thumb" src="/books/NBK27323/bin/ch38macular-Image009.gif" src-large="/books/NBK27323/bin/ch38macular-Image009.jpg" alt="Figure 8. . Color fundus photograph (a), early fluorescein angiogram (b) and late fluorescein angiogram (c)." /></a><div class="icnblk_cntnt" id="figlgndch38macularF8"><h4 id="ch38macular.F8"><a href="/books/NBK27323/figure/ch38macular.F8/?report=objectonly" target="object" rid-ob="figobch38macularF8">Figure 8. </a></h4><p class="float-caption no_bottom_margin">Color fundus photograph (a), early fluorescein angiogram (b) and late fluorescein angiogram (c). Arrowhead depicts edge of macular lesion. Note the lacey appearance of vessels (asterisk) in the early angiogram. </p></div></div><p><a class="figpopup" href="/books/NBK27323/figure/ch38macular.F9/?report=objectonly" target="object" rid-figpopup="figch38macularF9" rid-ob="figobch38macularF9">Fig. 9</a> shows a similar set of fundus pictures from an individual with occult choroidal neovascularization. A single, small punctate region of hemorrhage (arrow) and a ring of exudates (arrowhead depicts edge) appear more pronounced than typically occur in classic CNV. This patients had a minimal hyperfluorescence in the early phase of the angiogram, in contrast to that observed in the early stage of classic CNV. Speckled macular hyperfluorescence is visible in the late stage angiogram (<a class="figpopup" href="/books/NBK27323/figure/ch38macular.F9/?report=objectonly" target="object" rid-figpopup="figch38macularF9" rid-ob="figobch38macularF9">Fig. 9c</a>).</p><div class="iconblock whole_rhythm clearfix ten_col fig" id="figch38macularF9" co-legend-rid="figlgndch38macularF9"><a href="/books/NBK27323/figure/ch38macular.F9/?report=objectonly" target="object" title="Figure 9. " class="img_link icnblk_img figpopup" rid-figpopup="figch38macularF9" rid-ob="figobch38macularF9"><img class="small-thumb" src="/books/NBK27323/bin/ch38macular-Image010.gif" src-large="/books/NBK27323/bin/ch38macular-Image010.jpg" alt="Figure 9. . Color fundus photograph (a), early fluorescein angiogram (b) and late fluorescein angiogram (c) from an individual with occult choroidal neovascularization." /></a><div class="icnblk_cntnt" id="figlgndch38macularF9"><h4 id="ch38macular.F9"><a href="/books/NBK27323/figure/ch38macular.F9/?report=objectonly" target="object" rid-ob="figobch38macularF9">Figure 9. </a></h4><p class="float-caption no_bottom_margin">Color fundus photograph (a), early fluorescein angiogram (b) and late fluorescein angiogram (c) from an individual with occult choroidal neovascularization. A single, small punctate region of hemorrhage (asterisk) and a ring of exudates (arrowhead depicts <a href="/books/NBK27323/figure/ch38macular.F9/?report=objectonly" target="object" rid-ob="figobch38macularF9">(more...)</a></p></div></div><p>In the case shown in <a class="figpopup" href="/books/NBK27323/figure/ch38macular.F10/?report=objectonly" target="object" rid-figpopup="figch38macularF10" rid-ob="figobch38macularF10">Fig. 10</a>, the individual had a macular pigment epithelial detachment (PED). A multilobulated, hyperfluorescent lesion with sharply demarcated borders (arrow) is clearly visible in the late stage angiogram of <a class="figpopup" href="/books/NBK27323/figure/ch38macular.F10/?report=objectonly" target="object" rid-figpopup="figch38macularF10" rid-ob="figobch38macularF10">Fig. 10a</a>, arrow. The OCT shown in <a class="figpopup" href="/books/NBK27323/figure/ch38macular.F10/?report=objectonly" target="object" rid-figpopup="figch38macularF10" rid-ob="figobch38macularF10">Fig. 10b</a>, contrasts with a normal OCT of the fovea (<a class="figpopup" href="/books/NBK27323/figure/ch38macular.F2/?report=objectonly" target="object" rid-figpopup="figch38macularF2" rid-ob="figobch38macularF2">Fig. 2</a>) by being a blister-like elevation of the retina and retinal pigment epithelial layer off Bruch's membrane and the choroid.</p><p>The end stage of such lesions of the macula as shown in the three previous patients is illustrated by the last patient (<a class="figpopup" href="/books/NBK27323/figure/ch38macular.F11/?report=objectonly" target="object" rid-figpopup="figch38macularF11" rid-ob="figobch38macularF11">Fig. 11</a>). The color fundus photograph shows that the patient has end stage (cicatricial) exudative AMD. A large disciform scar (arrowhead) covers the whole macular region. Such a patient would be almost totally blind in that eye.</p></div></div><div id="ch38macular.Pathology_of_AMD"><h2 id="_ch38macular_Pathology_of_AMD_">Pathology of AMD</h2><div id="ch38macular.Overview"><h3>Overview</h3><p>Until quite recently, the majority of research on AMD and the development of therapeutics for the disease has focused upon late-stage neovascular events. No clear-cut sequence for the initiation and progression of AMD has been identified that would allow it to be monitored and treated in its earliest stages. Moreover, the pathologic correlates of the different clinical phenotypes of AMD remain poorly understood, and there is a paucity of animal models that accurately mimic the characteristic features of the disease. Nevertheless, recent discoveries are beginning to provide a much clearer picture of the relevant cellular events, genetic factors, and biochemical processes that are associated with early AMD. This new information should hasten significantly the development of clinically effective diagnostics and therapeutics for the treatment of this devastating condition.</p></div><div id="ch38macular.Morphological_Correlates_of"><h3>Morphological Correlates of Early AMD</h3><p>From a histopathologic standpoint, the earliest detectable changes associated with AMD occur at the interface between the macular retina and the underlying layer of connective tissue and blood vessels known as the choroid (<a class="bk_pop" href="#ch38macular.REF.66" data-bk-pop-others="ch38macular.REF.67 ch38macular.REF.68 ch38macular.REF.69 ch38macular.REF.70">66-70</a>). At this location lie the outer segments of rod and cone photoreceptors, the retinal pigment epithelial (RPE) cells, a stratified basement membrane complex termed Bruch's membrane (BM), and the choroidal capillary bed or choriocapillaris (<a class="figpopup" href="/books/NBK27323/figure/ch38macular.Fa/?report=objectonly" target="object" rid-figpopup="figch38macularFa" rid-ob="figobch38macularFa">Figs. 12</a>, <a class="figpopup" href="/books/NBK27323/figure/ch38macular.F13/?report=objectonly" target="object" rid-figpopup="figch38macularF13" rid-ob="figobch38macularF13">13</a>, BV of choroid).</p><div class="iconblock whole_rhythm clearfix ten_col fig" id="figch38macularFa" co-legend-rid="figlgndch38macularFa"><a href="/books/NBK27323/figure/ch38macular.Fa/?report=objectonly" target="object" title="Figure. " class="img_link icnblk_img figpopup" rid-figpopup="figch38macularFa" rid-ob="figobch38macularFa"><img class="small-thumb" src="/books/NBK27323/bin/ch38macular-Image013.gif" src-large="/books/NBK27323/bin/ch38macular-Image013.jpg" alt="Figure. . 12." /></a><div class="icnblk_cntnt" id="figlgndch38macularFa"><h4 id="ch38macular.Fa"><a href="/books/NBK27323/figure/ch38macular.Fa/?report=objectonly" target="object" rid-ob="figobch38macularFa">Figure. </a></h4><p class="float-caption no_bottom_margin">12. Light microscopic image depicting the choroid-RPE-retina interface. A section shows the normal anatomical relationships of the macular choroid (CH) with blood vessels (BV), retinal pigment epithelium (RPE) and neural retina (R); the section passes <a href="/books/NBK27323/figure/ch38macular.Fa/?report=objectonly" target="object" rid-ob="figobch38macularFa">(more...)</a></p></div></div><p>The initial clinical diagnosis of early AMD is based on seeing drusen - the hallmark indicators of disease - and/or pigmentary changes in the macula. Drusen look like yellow-white spots in the retina (<a class="figpopup" href="/books/NBK27323/figure/ch38macular.F3/?report=objectonly" target="object" rid-figpopup="figch38macularF3" rid-ob="figobch38macularF3">Figs. 3</a>-<a class="figpopup" href="/books/NBK27323/figure/ch38macular.F4/?report=objectonly" target="object" rid-figpopup="figch38macularF4" rid-ob="figobch38macularF4">maculardegen.F4</a><a class="figpopup" href="/books/NBK27323/figure/ch38macular.F5/?report=objectonly" target="object" rid-figpopup="figch38macularF5" rid-ob="figobch38macularF5">maculardegen.F5</a><a class="figpopup" href="/books/NBK27323/figure/ch38macular.F6/?report=objectonly" target="object" rid-figpopup="figch38macularF6" rid-ob="figobch38macularF6">maculardegen.F6</a><a class="figpopup" href="/books/NBK27323/figure/ch38macular.F7/?report=objectonly" target="object" rid-figpopup="figch38macularF7" rid-ob="figobch38macularF7">7</a>). They are extracellular deposits located between the retinal pigment epithelial (RPE) basal lamina and the inner collagenous layer of the elastin-containing Bruch's membrane as illustrated in the schematic of <a class="figpopup" href="/books/NBK27323/figure/ch38macular.F13/?report=objectonly" target="object" rid-figpopup="figch38macularF13" rid-ob="figobch38macularF13">Fig. 13</a> (<a class="bk_pop" href="#ch38macular.REF.71">71</a>); The normal retinal choroidal interface is shown in comparison to the drusen bearing abnormal interface. <a class="figpopup" href="/books/NBK27323/figure/ch38macular.F14/?report=objectonly" target="object" rid-figpopup="figch38macularF14" rid-ob="figobch38macularF14">Fig. 14</a> shows an actual histological section of retina where drusen are seen between the choroid and Bruch's membrane.</p><p>Bruch's membrane consists of an elastin core flanked on both sides by a collagenous layer and a basal lamina (see <a class="figpopup" href="/books/NBK27323/figure/ch38macular.F13/?report=objectonly" target="object" rid-figpopup="figch38macularF13" rid-ob="figobch38macularF13">Fig. 13</a>) (<a class="bk_pop" href="#ch38macular.REF.76" data-bk-pop-others="ch38macular.REF.77 ch38macular.REF.78 ch38macular.REF.79">76-79</a>). It is widely believed that the barrier properties of the RPE and Bruch's membrane limit cellular migration, especially the invasion of neovascular tissue from the choroid into the subretinal space. Our understanding of the molecular composition of Bruch's membrane, the molecular traffic that occurs across it, and the homeostatic mechanisms that maintain it, during normal aging as well as in AMD, is still rudimentary (<a class="bk_pop" href="#ch38macular.REF.80">80</a>).</p><p>Links between AMD and structural abnormalities in Bruch's membrane have been documented in numerous histopathologic studies. Classically, these Bruch's membrane defects have been described as fragmentation or fracturing in association with calcification (<a class="bk_pop" href="#ch38macular.REF.81" data-bk-pop-others="ch38macular.REF.82 ch38macular.REF.83 ch38macular.REF.84 ch38macular.REF.85">81-85</a>). Additional age-related changes in Bruch's membrane are typified by; a) Progressive thickening of the two collagenous layers; b) Modification and degeneration of collagen and elastin; c) Increased levels of advanced glycation end products, noncollagenous proteins and lipids; and d) Accumulation of several types of sub-RPE deposits (<a class="figpopup" href="/books/NBK27323/figure/ch38macular.F13/?report=objectonly" target="object" rid-figpopup="figch38macularF13" rid-ob="figobch38macularF13">Fig. 13</a>) (<a class="bk_pop" href="#ch38macular.REF.86" data-bk-pop-others="ch38macular.REF.87 ch38macular.REF.88 ch38macular.REF.89 ch38macular.REF.90 ch38macular.REF.91 ch38macular.REF.92 ch38macular.REF.93 ch38macular.REF.94 ch38macular.REF.95">86-95</a>). It has also been suggested that the age-related abnormalities in Bruch's membrane eventually lead to photoreceptor degeneration as a result of increased hydrophobicity, reduced permeability, and impaired nutrient exchange between the choroid and the RPE. Functionally, such changes result in an exponential reduction in the hydraulic conductivity of Bruch's membrane as a function of age (<a class="bk_pop" href="#ch38macular.REF.96" data-bk-pop-others="ch38macular.REF.97 ch38macular.REF.98 ch38macular.REF.99">96-99</a>). Much less is known about changes in Bruch's membrane hydraulic conductivity in individuals with AMD.</p><p>It has been proposed that topographic variations in Bruch's membrane may render the macula more susceptible to the ingrowth of new blood vessels from the choroidal vasculature that characterizes neovascular AMD. Morphometric data indicate that the elastic lamina of Bruch's membrane in the macula is 3-6 fold thinner and 2-5 fold less dense relative to that in the mid-periphery in individuals of all ages (<a class="bk_pop" href="#ch38macular.REF.100">100</a>). Elastin fiber destruction in the macula could also play a key role in the initiation of neovascular events because elastin degradation peptides are highly angiogenic and possess macrophage recruiting activity (<a class="bk_pop" href="#ch38macular.REF.101">101</a>).</p><p>In addition to drusen, basal laminar deposits (BLamD) and basal linear deposits (BLinD) accumulate within the extracellular environment of the RPE-choroid interface (<a class="figpopup" href="/books/NBK27323/figure/ch38macular.F13/?report=objectonly" target="object" rid-figpopup="figch38macularF13" rid-ob="figobch38macularF13">Figs. 13</a>, <a class="figpopup" href="/books/NBK27323/figure/ch38macular.F15/?report=objectonly" target="object" rid-figpopup="figch38macularF15" rid-ob="figobch38macularF15">15</a>-<a class="figpopup" href="/books/NBK27323/figure/ch38macular.F16/?report=objectonly" target="object" rid-figpopup="figch38macularF16" rid-ob="figobch38macularF16">maculardegen.F16</a><a class="figpopup" href="/books/NBK27323/figure/ch38macular.F17/?report=objectonly" target="object" rid-figpopup="figch38macularF17" rid-ob="figobch38macularF17">17</a>). These are identified based upon their morphological appearance and location. Both types of deposits have been proposed by various investigators to be involved in the pathogenesis of AMD (<a class="bk_pop" href="#ch38macular.REF.103">103</a>). Neutral lipid (including esterified cholesterol) and apolipoproteins B and E are abundant in these basal deposits and in drusen in the eyes of aged donors and donors with a documented history of AMD (<a class="bk_pop" href="#ch38macular.REF.88" data-bk-pop-others="ch38macular.REF.94 ch38macular.REF.104 ch38macular.REF.105 ch38macular.REF.106 ch38macular.REF.107">88, 94, 104-107</a>).</p><div class="iconblock whole_rhythm clearfix ten_col fig" id="figch38macularF17" co-legend-rid="figlgndch38macularF17"><a href="/books/NBK27323/figure/ch38macular.F17/?report=objectonly" target="object" title="Figure 17. " class="img_link icnblk_img figpopup" rid-figpopup="figch38macularF17" rid-ob="figobch38macularF17"><img class="small-thumb" src="/books/NBK27323/bin/ch38macular-Image018.gif" src-large="/books/NBK27323/bin/ch38macular-Image018.jpg" alt="Figure 17. . Light microscopic image depicting the choroid-RPE-retina interface." /></a><div class="icnblk_cntnt" id="figlgndch38macularF17"><h4 id="ch38macular.F17"><a href="/books/NBK27323/figure/ch38macular.F17/?report=objectonly" target="object" rid-ob="figobch38macularF17">Figure 17. </a></h4><p class="float-caption no_bottom_margin">Light microscopic image depicting the choroid-RPE-retina interface. New choroidal blood vessels are located in both the sub-RPE and subretinal spaces (arrows). </p></div></div><p>Basal laminar deposits (BLamD) that accumulate between the RPE basal plasma membrane and its basal lamina (<a class="figpopup" href="/books/NBK27323/figure/ch38macular.F13/?report=objectonly" target="object" rid-figpopup="figch38macularF13" rid-ob="figobch38macularF13">Figs.13</a>, <a class="figpopup" href="/books/NBK27323/figure/ch38macular.F15/?report=objectonly" target="object" rid-figpopup="figch38macularF15" rid-ob="figobch38macularF15">15</a>-<a class="figpopup" href="/books/NBK27323/figure/ch38macular.F16/?report=objectonly" target="object" rid-figpopup="figch38macularF16" rid-ob="figobch38macularF16">maculardegen.F16</a><a class="figpopup" href="/books/NBK27323/figure/ch38macular.F17/?report=objectonly" target="object" rid-figpopup="figch38macularF17" rid-ob="figobch38macularF17">17</a>) do not appear to be specific to or 'diagnostic' for AMD. However, there is a strong relationship between macular BLamD and exudative AMD, disciform scarring, and visual loss (<a class="bk_pop" href="#ch38macular.REF.74" data-bk-pop-others="ch38macular.REF.84 ch38macular.REF.108 ch38macular.REF.109 ch38macular.REF.110 ch38macular.REF.111 ch38macular.REF.112 ch38macular.REF.113 ch38macular.REF.114 ch38macular.REF.115">74, 84, 108-115</a>). BLamD-like deposits are also seen in other macular disorders with a clinical appearance similar to what is observed in AMD. These include Sorsby's fundus dystrophy, Late Onset Retinal Degeneration (LORD), adult foveomacular pigment epithelial dystrophy and Malattia leventinese (<a class="bk_pop" href="#ch38macular.REF.116">116</a>). The molecular composition and origin of BLamD has not yet been identified (<a class="bk_pop" href="#ch38macular.REF.117" data-bk-pop-others="ch38macular.REF.118 ch38macular.REF.119">117-119</a>), but its morphological similarity to long-spacing collagen is striking. Electron microscopy has revealed that its banding pattern matches that of type VI collagen (<a class="bk_pop" href="#ch38macular.REF.120">120</a>).</p><p>Electron microscopy shows the changes that occur at the choroids RPB interface in AMD at a more detailed level. <a class="figpopup" href="/books/NBK27323/figure/ch38macular.F18/?report=objectonly" target="object" rid-figpopup="figch38macularF18" rid-ob="figobch38macularF18">Figures 18</a> and <a class="figpopup" href="/books/NBK27323/figure/ch38macular.F19/?report=objectonly" target="object" rid-figpopup="figch38macularF19" rid-ob="figobch38macularF19">19</a> indicate a normal retinal choroidal interface (<a class="figpopup" href="/books/NBK27323/figure/ch38macular.F18/?report=objectonly" target="object" rid-figpopup="figch38macularF18" rid-ob="figobch38macularF18">Fig. 18</a>) compared with an abnormal AMD-like situation where there are drusen forming at this interface (<a class="figpopup" href="/books/NBK27323/figure/ch38macular.F19/?report=objectonly" target="object" rid-figpopup="figch38macularF19" rid-ob="figobch38macularF19">Fig. 19</a>).</p><div class="iconblock whole_rhythm clearfix ten_col fig" id="figch38macularF18" co-legend-rid="figlgndch38macularF18"><a href="/books/NBK27323/figure/ch38macular.F18/?report=objectonly" target="object" title="Figure 18. " class="img_link icnblk_img figpopup" rid-figpopup="figch38macularF18" rid-ob="figobch38macularF18"><img class="small-thumb" src="/books/NBK27323/bin/ch38macular-Image019.gif" src-large="/books/NBK27323/bin/ch38macular-Image019.jpg" alt="Figure 18. . Transmission electron micrograph of the RPE-choroid interface in a normal human donor eye." /></a><div class="icnblk_cntnt" id="figlgndch38macularF18"><h4 id="ch38macular.F18"><a href="/books/NBK27323/figure/ch38macular.F18/?report=objectonly" target="object" rid-ob="figobch38macularF18">Figure 18. </a></h4><p class="float-caption no_bottom_margin">Transmission electron micrograph of the RPE-choroid interface in a normal human donor eye. </p></div></div><div class="iconblock whole_rhythm clearfix ten_col fig" id="figch38macularF19" co-legend-rid="figlgndch38macularF19"><a href="/books/NBK27323/figure/ch38macular.F19/?report=objectonly" target="object" title="Figure 19. " class="img_link icnblk_img figpopup" rid-figpopup="figch38macularF19" rid-ob="figobch38macularF19"><img class="small-thumb" src="/books/NBK27323/bin/ch38macular-Image020.gif" src-large="/books/NBK27323/bin/ch38macular-Image020.jpg" alt="Figure 19. . Transmission eectron micrograph of a donor eye with AMD." /></a><div class="icnblk_cntnt" id="figlgndch38macularF19"><h4 id="ch38macular.F19"><a href="/books/NBK27323/figure/ch38macular.F19/?report=objectonly" target="object" rid-ob="figobch38macularF19">Figure 19. </a></h4><p class="float-caption no_bottom_margin">Transmission eectron micrograph of a donor eye with AMD. A single drusen (D) is shown to be located between the RPE basal lamina (arrowheads) and Bruch's membrane (BM). </p></div></div><p>BlinD lies between the RPE basal lamina and the elastic layer of Bruch's membrane (<a class="figpopup" href="/books/NBK27323/figure/ch38macular.F20/?report=objectonly" target="object" rid-figpopup="figch38macularF20" rid-ob="figobch38macularF20">Fig. 20</a>). The principal component of BLinD is a distinct form of membranous debris, thought to be comprised primarily of lipoprotein particles containing neutral lipids, including esterified cholesterol. It is likely that BLinD is derived from local ocular sources (e.g. RPE cells) (<a class="bk_pop" href="#ch38macular.REF.121">121</a>). BLinD were initially described by Sarks and colleagues (<a class="bk_pop" href="#ch38macular.REF.122">122</a>) as lipid-like vesicles with varying diameters.</p><div class="iconblock whole_rhythm clearfix ten_col fig" id="figch38macularF20" co-legend-rid="figlgndch38macularF20"><a href="/books/NBK27323/figure/ch38macular.F20/?report=objectonly" target="object" title="Figure 20. " class="img_link icnblk_img figpopup" rid-figpopup="figch38macularF20" rid-ob="figobch38macularF20"><img class="small-thumb" src="/books/NBK27323/bin/ch38macular-Image021.gif" src-large="/books/NBK27323/bin/ch38macular-Image021.jpg" alt="Figure 20. . Electron micrograph shows BLamD (asterisk) accumulates between the basal surface of the RPE and its basal lamina (arrow), whereas BLinD is located within the innermost aspect of Bruch's membrane, in a case of AMD." /></a><div class="icnblk_cntnt" id="figlgndch38macularF20"><h4 id="ch38macular.F20"><a href="/books/NBK27323/figure/ch38macular.F20/?report=objectonly" target="object" rid-ob="figobch38macularF20">Figure 20. </a></h4><p class="float-caption no_bottom_margin">Electron micrograph shows BLamD (asterisk) accumulates between the basal surface of the RPE and its basal lamina (arrow), whereas BLinD is located within the innermost aspect of Bruch's membrane, in a case of AMD. </p></div></div><p>It is believed that the pigmentary changes often observed in the macula of AMD eyes are attributable to degenerative changes in the highly melanized RPE cells (<a class="figpopup" href="/books/NBK27323/figure/ch38macular.F20/?report=objectonly" target="object" rid-figpopup="figch38macularF20" rid-ob="figobch38macularF20">Fig. 20</a>). This notion has gained wide acceptance because most of the early clinical signs and histopathological changes have been localized to this cell layer (<a class="bk_pop" href="#ch38macular.REF.123" data-bk-pop-others="ch38macular.REF.124 ch38macular.REF.125 ch38macular.REF.126">123-126</a>). It has long been recognized that the RPE is essential for the transport of ions, nutrients, and metabolites from the circulation to the neural retina and vice versa (<a class="bk_pop" href="#ch38macular.REF.127">127</a>). If the RPE interface to the Bruch's membrane is broken down, amongst other things, blood vessels from the choroids can grow into this space (<a class="figpopup" href="/books/NBK27323/figure/ch38macular.F21/?report=objectonly" target="object" rid-figpopup="figch38macularF21" rid-ob="figobch38macularF21">Fig. 21</a>).</p><div class="iconblock whole_rhythm clearfix ten_col fig" id="figch38macularF21" co-legend-rid="figlgndch38macularF21"><a href="/books/NBK27323/figure/ch38macular.F21/?report=objectonly" target="object" title="Figure 21. " class="img_link icnblk_img figpopup" rid-figpopup="figch38macularF21" rid-ob="figobch38macularF21"><img class="small-thumb" src="/books/NBK27323/bin/ch38macular-Image022.gif" src-large="/books/NBK27323/bin/ch38macular-Image022.jpg" alt="Figure 21. . Electron micrograph shows a patent choroidal neovessel (asterisk), lying between BM and a layer of BLamD (rectangle) in a case of advanced AMD." /></a><div class="icnblk_cntnt" id="figlgndch38macularF21"><h4 id="ch38macular.F21"><a href="/books/NBK27323/figure/ch38macular.F21/?report=objectonly" target="object" rid-ob="figobch38macularF21">Figure 21. </a></h4><p class="float-caption no_bottom_margin">Electron micrograph shows a patent choroidal neovessel (asterisk), lying between BM and a layer of BLamD (rectangle) in a case of advanced AMD. RPE, retinal pigment epithelium; BM, Bruch's membrane. </p></div></div><p>A viable RPE is also essential for normal photoreceptor cell metabolism and functioning of the visual cycle. Therefore, it is not surprising that RPE degeneration is accompanied by concomitant photoreceptor degeneration. RPE dysfunction in the macula, whether caused by local environmental insults and/or genetic defect(s), would have a profound impact on the overlying photoreceptors and, therefore, on central vision. However, the nature of the insult(s) that causes RPE dysfunction has yet to be ascertained, although a variety of hypotheses have been advanced over the years including genetic factors, ischemia, oxidative stress, phagocytic overload, cigarette smoke, lipofuscin toxicity and, most recently, microbial infection (<a class="bk_pop" href="#ch38macular.REF.128" data-bk-pop-others="ch38macular.REF.129 ch38macular.REF.130 ch38macular.REF.131 ch38macular.REF.132 ch38macular.REF.133 ch38macular.REF.134">128-134</a>).</p><p>The choriocapillaris has also been suspected to play a role in the etiology of AMD. The density and diameters of the choriocapillaris capillaries decreases with age, and this decrease is even greater in patients with AMD. The overall loss appears most marked in regions of geographic atrophy (<a class="bk_pop" href="#ch38macular.REF.135" data-bk-pop-others="ch38macular.REF.136">135, 136</a>).</p></div></div><div id="ch38macular.Physiology_of_early_AMD"><h2 id="_ch38macular_Physiology_of_early_AMD_">Physiology of early AMD</h2><p>There is substantial evidence of photoreceptor involvement in early AMD, particularly in those patients with soft or large drusen in the macula (<a class="bk_pop" href="#ch38macular.REF.137" data-bk-pop-others="ch38macular.REF.138 ch38macular.REF.139 ch38macular.REF.140 ch38macular.REF.141 ch38macular.REF.142 ch38macular.REF.143 ch38macular.REF.144 ch38macular.REF.145">137-145</a>). Contrast sensitivity, the rate of recovery after photostress, the amplitude and latency of the foveal electroretinogram (ERG) response, and dark adaptation are all affected adversely in early AMD patients, including those with normal visual acuity (<a class="bk_pop" href="#ch38macular.REF.140" data-bk-pop-others="ch38macular.REF.146 ch38macular.REF.147 ch38macular.REF.148 ch38macular.REF.149 ch38macular.REF.150 ch38macular.REF.151">140, 146-151</a>). <a class="figpopup" href="/books/NBK27323/figure/ch38macular.F22/?report=objectonly" target="object" rid-figpopup="figch38macularF22" rid-ob="figobch38macularF22">Fig. 22</a> shows the multifocal ERG responses from the macular area of a patient with AMD (<a href="/books/n/webvision/ch36clinicalerg/">see chapter on the clinical ERG, multifocal ERG</a>). The responses of the fovea are reduced in amplitude. In the 3-D map (<a class="figpopup" href="/books/NBK27323/figure/ch38macular.F23/?report=objectonly" target="object" rid-figpopup="figch38macularF23" rid-ob="figobch38macularF23">Fig. 23</a>) it can be seen that the foveal area is flat, suggesting no cone activity, compared with the characteristic peak of responses in the normal retina.</p><div class="iconblock whole_rhythm clearfix ten_col fig" id="figch38macularF22" co-legend-rid="figlgndch38macularF22"><a href="/books/NBK27323/figure/ch38macular.F22/?report=objectonly" target="object" title="Figure 22. " class="img_link icnblk_img figpopup" rid-figpopup="figch38macularF22" rid-ob="figobch38macularF22"><img class="small-thumb" src="/books/NBK27323/bin/ch38macular-Image023.gif" src-large="/books/NBK27323/bin/ch38macular-Image023.jpg" alt="Figure 22. . Multifocal ERG recordings in a patient with age related macular degeneration (AMD)." /></a><div class="icnblk_cntnt" id="figlgndch38macularF22"><h4 id="ch38macular.F22"><a href="/books/NBK27323/figure/ch38macular.F22/?report=objectonly" target="object" rid-ob="figobch38macularF22">Figure 22. </a></h4><p class="float-caption no_bottom_margin">Multifocal ERG recordings in a patient with age related macular degeneration (AMD). Note the central resposes where the fovea is located are much reduced in amplitude. </p></div></div><div class="iconblock whole_rhythm clearfix ten_col fig" id="figch38macularF23" co-legend-rid="figlgndch38macularF23"><a href="/books/NBK27323/figure/ch38macular.F23/?report=objectonly" target="object" title="Figure 23. " class="img_link icnblk_img figpopup" rid-figpopup="figch38macularF23" rid-ob="figobch38macularF23"><img class="small-thumb" src="/books/NBK27323/bin/ch38macular-Image024.gif" src-large="/books/NBK27323/bin/ch38macular-Image024.jpg" alt="Figure 23. . Multifocal ERG recordings transformed into 3-D maps of the macular area in a patient with AMD compared to a normal patient." /></a><div class="icnblk_cntnt" id="figlgndch38macularF23"><h4 id="ch38macular.F23"><a href="/books/NBK27323/figure/ch38macular.F23/?report=objectonly" target="object" rid-ob="figobch38macularF23">Figure 23. </a></h4><p class="float-caption no_bottom_margin">Multifocal ERG recordings transformed into 3-D maps of the macular area in a patient with AMD compared to a normal patient. The AMD patient has no responses in the fovea. </p></div></div><p>It has been shown that photoreceptor cells in areas impacted by drusen exhibit morphologic and biochemical signs of degeneration, including decreased expression of synapse-associated proteins and increased expression of stress-response molecules. There are also drusen-associated reductions in photoreceptor cell densities, thus suggesting that degenerative changes in photoreceptors ultimately lead to cell death (<a class="bk_pop" href="#ch38macular.REF.152" data-bk-pop-others="ch38macular.REF.153">152, 153</a>).</p></div><div id="ch38macular.Inflammation_and_AMD"><h2 id="_ch38macular_Inflammation_and_AMD_">Inflammation and AMD</h2><p>Recent studies of the molecular composition of drusen have implicated local inflammation as a key element in the pathogenesis of AMD (<a class="bk_pop" href="#ch38macular.REF.154" data-bk-pop-others="ch38macular.REF.155 ch38macular.REF.156 ch38macular.REF.157 ch38macular.REF.158 ch38macular.REF.159 ch38macular.REF.160">154-160</a>). Drusen contain numerous proteins related to the process of inflammation or its aftermath (<a class="bk_pop" href="#ch38macular.REF.106" data-bk-pop-others="ch38macular.REF.161 ch38macular.REF.162 ch38macular.REF.163 ch38macular.REF.164">106, 161-164</a>). In particular, many of these proteins are associated with the complement cascade and its regulation. Some of the proteinaceous components in drusen and the sub-RPE space are activated complement components and fragments associated with assembly of the membrane attack complex (MAC) (<a class="bk_pop" href="#ch38macular.REF.162" data-bk-pop-others="ch38macular.REF.165 ch38macular.REF.166 ch38macular.REF.167 ch38macular.REF.168">162, 165-168</a>). Other drusen components including vitronectin (<a class="bk_pop" href="#ch38macular.REF.161">161</a>), clusterin, complement receptor 1 (CR1), and membrane cofactor protein (MCP-1) (<a class="bk_pop" href="#ch38macular.REF.164">164</a>) are known complement regulatory proteins. Still others include known activators of the complement cascade such as cholesterol (<a class="bk_pop" href="#ch38macular.REF.169">169</a>), C-reactive protein (<a class="bk_pop" href="#ch38macular.REF.155">155</a>), and the amyloidogenic peptide amyloid b (<a class="bk_pop" href="#ch38macular.REF.153" data-bk-pop-others="ch38macular.REF.170">153, 170</a>). Metallic zinc, an amyloid b binding molecule, is also a drusen constituent (<a class="bk_pop" href="#ch38macular.REF.171">171</a>). This compositional profile forms the basis for the conclusion that drusen are a manifestation of chronic, local inflammation at the level of Bruch's membrane.</p></div><div id="ch38macular.The_Complement_System_and_AM"><h2 id="_ch38macular_The_Complement_System_and_AM_">The Complement System and AMD</h2><p>Three complement pathways can be distinguished by the "triggers" that activate them. 1) antigen-antibody binding triggers the "classical pathway". 2) carbohydrate residues bound to invading pathogens trigger the "lectin pathway. 3) A low level of spontaneous activation known as "tickover" characterizes the "alternative pathway". This continuous background level of activation is amplified rapidly by ubiquitous components present on the surfaces of many bacteria, viruses, as well as constituents present in cigarette smoke.</p><div id="ch38macular.Complement_Factor_H_the_Comp"><h3>Complement Factor H, the Complement Alternative Pathway and AMD</h3><p>Factor H is the main soluble inhibitor of the "alternative pathway" and, like most complement components, the liver is responsible for 80-90% of Factor H protein synthesis (<a class="bk_pop" href="#ch38macular.REF.190" data-bk-pop-others="ch38macular.REF.191 ch38macular.REF.192">190-192</a>). We now know that variants in the gene encoding Factor H play a central role in one's susceptibility to AMD (see below). All of the available data are consistent with the conclusion that uncontrolled activation of the alternative pathway of complement at the level of Bruch's membrane is a key element in the process of drusen formation and a major contributing factor to the pathogenesis of AMD.</p><p>Although the liver is responsible for most circulating Factor H, the eye is also capable of producing it, in addition to other complement components. Not surprisingly, Factor H protein is also a molecular constituent of drusen (<a class="bk_pop" href="#ch38macular.REF.193">193</a>). It co-localizes with its ligand C3b (a complement pathway component) in substructural spherules within drusen that contain amyloid b, further implicating these structures as candidate complement activators (<a class="bk_pop" href="#ch38macular.REF.170" data-bk-pop-others="ch38macular.REF.194">170, 194</a>). Factor H and the MAC co-distribute in drusen and at the interface between the RPE and choroid. Finally, Factor H and C5b-9 (MAC) immunolabeling are more intense in the macula compared to tissues from more peripheral areas in the same eye (Hageman and Mullins, unpublished).</p><p>We have advanced a working model of AMD pathobiology based upon our studies (<a class="bk_pop" href="#ch38macular.REF.155" data-bk-pop-others="ch38macular.REF.195">155, 195</a>) and the work of others (<a class="bk_pop" href="#ch38macular.REF.157" data-bk-pop-others="ch38macular.REF.196">157, 196</a>). In this model, RPE atrophy and the subsequent deposition of cellular debris in the sub-RPE space is construed as a local pro-inflammatory "seeding" event, leading to activation of the innate immune system at the RPE-choroid interface. Complement attack, in turn, induces significant bystander damage to macular cells and tissues, thus rendering them susceptible to additional RPE atrophy, photoreceptor degeneration, and CNV.(The reader, who is interested, can see diagrams showing the way the complement cascade works, in a paper by Ricklin and Lambris, 2007) (<a class="bk_pop" href="#ch38macular.REF.247">247</a>).</p></div></div><div id="ch38macular.Molecular_genetics_of_AMD"><h2 id="_ch38macular_Molecular_genetics_of_AMD_">Molecular genetics of AMD</h2><div id="ch38macular.Overview_1"><h3>Overview</h3><p>AMD is often regarded as a group of complex, late onset diseases caused by the convergence of multiple risk factors (<a class="bk_pop" href="#ch38macular.REF.197" data-bk-pop-others="ch38macular.REF.198">197, 198</a>). Family history is a consistent risk factor according to most epidemiological studies of AMD conducted to date. Familial aggregation studies have shown that a genetic contribution is identified in up to 25% of AMD cases (<a class="bk_pop" href="#ch38macular.REF.199">199</a>). Twin studies also support a genetic basis for the disease, with the concordance of clinical features (drusen and pigmentary changes) for both early and late onset disease being approximately twice as high in monozygotic (identical) twins compared to dizygotic (non-identical) twins (<a class="bk_pop" href="#ch38macular.REF.200" data-bk-pop-others="ch38macular.REF.201">200, 201</a>).</p><p>Genome-wide linkage analyses of extended families with AMD have identified a number of chromosomal loci that are linked to AMD (<a class="bk_pop" href="#ch38macular.REF.202" data-bk-pop-others="ch38macular.REF.203 ch38macular.REF.204 ch38macular.REF.205 ch38macular.REF.206 ch38macular.REF.207 ch38macular.REF.208 ch38macular.REF.209 ch38macular.REF.210">202-210</a>). The most consistent occurs at chromosome 1q31 (<a class="bk_pop" href="#ch38macular.REF.211">211</a>). Between 15-40% of multiplex AMD families segregate with a disease gene in the 1q31 region (<a class="bk_pop" href="#ch38macular.REF.205">205</a>). Further analysis of this region reveals an allelic variant in exon 104 of the fibulin-6 gene (FBLN-6) in members of one AMD family, as well as in some sporadic AMD cases (<a class="bk_pop" href="#ch38macular.REF.212">212</a>). A number of other candidate genes have also been linked to AMD. However, most of these results have not yet been replicated in subsequent studies. These genes include ELOVL4 (<a class="bk_pop" href="#ch38macular.REF.213">213</a>), VEGF, VLDLR, and LRP6 (<a class="bk_pop" href="#ch38macular.REF.214">214</a>), FIBLN5 (<a class="bk_pop" href="#ch38macular.REF.215">215</a>) and TLR-4 (<a class="bk_pop" href="#ch38macular.REF.216">216</a>).</p><p>In contrast, the e4 allele of the apolipoprotein E (APOE) gene has consistently been shown to be protective for AMD (<a class="bk_pop" href="#ch38macular.REF.217" data-bk-pop-others="ch38macular.REF.218 ch38macular.REF.219">217-219</a>), whereas the e2 allele appears to influence progression and to result in an earlier age of onset (<a class="bk_pop" href="#ch38macular.REF.219">219</a>). ABCA4 confers increased risk for AMD too (<a class="bk_pop" href="#ch38macular.REF.220">220</a>).</p><p>In early 2005, four groups reported independently that common variants [single nucleotide polymorphisms (SNPs)] in the gene encoding complement Factor H (CFH) confer major susceptibility to, or protection from, AMD (<a class="bk_pop" href="#ch38macular.REF.193" data-bk-pop-others="ch38macular.REF.221 ch38macular.REF.222 ch38macular.REF.223">193, 221-223</a>). Individuals who possess a single copy of the risk-conferring CFH haplotype have 2-4 fold higher lifetime risk of developing AMD, and those with two copies possess a 5-7 fold higher lifetime risk. Haplotype analysis showed that a SNP in the CFH gene can account for up to 50% of AMD cases in the human population, a number approaching 50,000,000 worldwide. Follow-up reports have since confirmed these findings in additional cohorts in the United States (<a class="bk_pop" href="#ch38macular.REF.213" data-bk-pop-others="ch38macular.REF.224">213, 224</a>), Iceland (<a class="bk_pop" href="#ch38macular.REF.225">225</a>), the United Kingdom (<a class="bk_pop" href="#ch38macular.REF.226">226</a>), and France (<a class="bk_pop" href="#ch38macular.REF.227">227</a>). Interestingly, the major CFH risk haplotype in the Japanese population appears to be different than that reported in other populations, although the protective haplotype is the same (<a class="bk_pop" href="#ch38macular.REF.228">228</a>).</p><p>In early 2006, a study showed that allelic variants in two other complement-related genes, Factor B (BF) and complement component C2, were linked to AMD (<a class="bk_pop" href="#ch38macular.REF.229">229</a>). These are paralogous genes located 500bp apart on chromosome 6p21, and both reside in the major histocompatibility complex (MHC) class III region. BF is a component of the alternative pathway of complement, whereas C2 is a component of the classical pathway. Both variants together can account for nearly 74% of the risk of developing AMD. The protective haplotype for each of the three genes was completely absent in nearly 75% of all AMD cases; whereas 56% of controls possessed at least one copy of a protective CFH or BF haplotype. Approximately 60% of the risk in AMD cases, and 65% of the protection in controls, can be assigned to the CFH gene locus alone.</p><p>In addition to the 1q31 locus, a region on chromosome 10q26 has been identified in several recent studies of AMD (<a class="bk_pop" href="#ch38macular.REF.211">211</a>) on a scale similar to that of the CFH Tyr402His variant. PLEKHA1 (pleckstrin homology domain-containing, family A, member 1) and a predicted LOC387715 gene were identified as the relevant candidate genes at that locus (<a class="bk_pop" href="#ch38macular.REF.231">231</a>). A subsequent study concluded that SNP rs10490924 in LOC387715 was the most likely AMD-susceptibility allele (<a class="bk_pop" href="#ch38macular.REF.232">232</a>). A third study identified a coding change in the LOC387715 gene as the significant allele that results in a non-synonymous substitution of alanine to serine at position 69 of the hypothetical protein. In addition, a significant statistical relationship between the LOC387715 variant and a history of cigarette smoking has been found (<a class="bk_pop" href="#ch38macular.REF.233">233</a>). Thus far, there is no published evidence for expression of the LOC387715 gene product at either the RNA or protein levels; nor is there any indication of its likely functional properties.</p></div></div><div id="ch38macular.Therapy_for_AMD"><h2 id="_ch38macular_Therapy_for_AMD_">Therapy for AMD</h2><p>The molecular pathogenesis of AMD has only recently begun to be elucidated. So, it is not surprising that the therapeutic approaches for AMD have been of only limited benefit to most patients. Therapeutic interventions have focused almost exclusively upon the exudative "wet" form that comprises approximately 10% of the AMD patient population because it is the most debilitating and rapidly progressive form of the disease. Until recently, such therapies have resulted in a benefit to less than 50% of patients with "wet" AMD, and therefore less than 5% of all AMD patients. Developing therapeutics to delay onset or progression of "dry" AMD or the conversion from "dry" to "wet" AMD, have proven even more difficult. This due to the long study duration and large numbers of participants needed to achieve meaningful statistical results.</p><p>Over the last 30 years epidemiological studies have repeatedly identified four risk factors for AMD: age, cigarette smoking, increased body mass index, and inheritance (<a class="bk_pop" href="#ch38macular.REF.10" data-bk-pop-others="ch38macular.REF.31 ch38macular.REF.32">10, 31, 32</a>). These same studies have produced conflicting information regarding the roles of dietary antioxidant supplementation and fat intake. In 1992 the Age-related Eye Disease Study (AREDS) group began enrolling subjects in a prospective, multicenter, randomized, controlled study (<a class="bk_pop" href="#ch38macular.REF.33">33</a>). Patients enrolled in the AREDS had either mild, moderate, or severe dry AMD in both eyes, or exudative AMD in one eye only. The study tried to determine whether antioxidant therapy prevented vision loss, slowed the progression of dry AMD, or prevented conversion from dry to wet AMD. The results of 6.3 years of follow-up in the AREDS study were published in 2001 (<a class="bk_pop" href="#ch38macular.REF.33">33</a>). The study results demonstrated that daily antioxidant therapy in the form of 15 mg beta carotene, 500 mg vitamin C, 50 mg vitamin E, 80 mg zinc (as zinc oxide), and 2mg copper (as cupric oxide) daily was superior to a placebo in delaying progression of advanced dry AMD, and in slowing conversion from dry to wet AMD. Specifically, the odds ratio of progression to advanced AMD was decreased to 0.72 in the group who took the above combination of antioxidants as compared to placebo. No benefit of antioxidant supplementation was demonstrated in the milder forms of AMD. However, because the early stages of AMD often persist for many years, it is quite possible that the study design was not long enough to demonstrate a benefit to patients with milder stages of AMD.</p><p>Another therapeutic intervention is laser therapy for eyes with drusen. Three prospective trials, the Choroidal Neovascularization Prevention Trial (CNVPT), Complications of AMD Prevention Trial (CAPT) and Prophylactic Treatment of Age-Related Macular Degeneration Trial (PTAMD) evaluated the efficacy and safety of light macular grid laser in reducing the risk of developing CNV in eyes with drusen. The CNVPT and CAPT used argon laser and the PTAMD used an 810 nm diode laser (<a class="bk_pop" href="#ch38macular.REF.34" data-bk-pop-others="ch38macular.REF.35 ch38macular.REF.36">34-36</a>). In both the CNVPT and PTAMD studies, grid laser treatment increased the risk of CNV. Therefore grid laser of eyes with drusen is not recommended if the fellow eye has CNV (<a class="bk_pop" href="#ch38macular.REF.36" data-bk-pop-others="ch38macular.REF.37">36, 37</a>). Recent results of the PTAMD bilateral drusen study reported no decrease in CNV development but a four-letter gain in visual acuity in treated versus control eyes after three years of follow-up (<a class="bk_pop" href="#ch38macular.REF.38">38</a>). The larger CAPT study of treatment of one eye in the setting of bilateral drusen is ongoing but near completion of five years of follow-up. Until the results of the CAPT study are known, prophylactic laser of eyes with bilateral drusen is not a recommended therapy.</p><p>Therapy for exudative AMD has evolved from thermal laser photocoagulation in the early to mid 1980's, to photodynamic therapy for CNV beginning in 2000 and, most recently to inhibition of vascular growth factors. The three year results of the Macular Photocoagulation Studies (MPS) for AMD was published in 1986. It demonstrated a benefit for "extrafoveal" CNV located between 200 and 3,000 microns from the fovea (<a class="figpopup" href="/books/NBK27323/figure/ch38macular.F24/?report=objectonly" target="object" rid-figpopup="figch38macularF24" rid-ob="figobch38macularF24">Fig. 24</a>). Subsequent MPS studies for juxtafoveal (1 - 200 microns from the fovea) CNV and subfoveal CNV respectively, demonstrated a benefit for laser treatment versus no treatment (<a class="figpopup" href="/books/NBK27323/figure/ch38macular.F24/?report=objectonly" target="object" rid-figpopup="figch38macularF24" rid-ob="figobch38macularF24">Fig. 24</a>) (<a class="bk_pop" href="#ch38macular.REF.39" data-bk-pop-others="ch38macular.REF.40 ch38macular.REF.41">39-41</a>).</p><div class="iconblock whole_rhythm clearfix ten_col fig" id="figch38macularF24" co-legend-rid="figlgndch38macularF24"><a href="/books/NBK27323/figure/ch38macular.F24/?report=objectonly" target="object" title="Figure 24. " class="img_link icnblk_img figpopup" rid-figpopup="figch38macularF24" rid-ob="figobch38macularF24"><img class="small-thumb" src="/books/NBK27323/bin/ch38macular-Image025.gif" src-large="/books/NBK27323/bin/ch38macular-Image025.jpg" alt="Figure 24. . a) New extrafoveal CNVM." /></a><div class="icnblk_cntnt" id="figlgndch38macularF24"><h4 id="ch38macular.F24"><a href="/books/NBK27323/figure/ch38macular.F24/?report=objectonly" target="object" rid-ob="figobch38macularF24">Figure 24. </a></h4><p class="float-caption no_bottom_margin">a) New extrafoveal CNVM. b) angiogram of extrafoveal CNVM (photos from KMG files). c) Laser scar after MPS-style laser for extrafoveal CNVM. d) Angiogram of laser scar after MPS- style laser for extrafoveal CNVM (photos from KMG files). </p></div></div><p>However, visual loss was common even in those eyes with successful obliteration of CNV (<a class="bk_pop" href="#ch38macular.REF.42">42</a>). Additionally, the closer the CNV was to the fovea, the poorer the visual outcome and the higher the rate of recurrence even in those who initially responded to treatment (<a class="bk_pop" href="#ch38macular.REF.43">43</a>). In 1993, Freund and coworkers demonstrated that only 13% of new patients with exudative AMD (or approximately 1.3% of all AMD patients) met criteria for thermal laser treatment based on the MPS (<a class="figpopup" href="/books/NBK27323/figure/ch38macular.F25/?report=objectonly" target="object" rid-figpopup="figch38macularF25" rid-ob="figobch38macularF25">Fig. 25</a>) (<a class="bk_pop" href="#ch38macular.REF.44">44</a>).</p><div class="iconblock whole_rhythm clearfix ten_col fig" id="figch38macularF25" co-legend-rid="figlgndch38macularF25"><a href="/books/NBK27323/figure/ch38macular.F25/?report=objectonly" target="object" title="Figure 25. " class="img_link icnblk_img figpopup" rid-figpopup="figch38macularF25" rid-ob="figobch38macularF25"><img class="small-thumb" src="/books/NBK27323/bin/ch38macular-Image026.gif" src-large="/books/NBK27323/bin/ch38macular-Image026.jpg" alt="Figure 25. . a) Subretinal hemorrhage and CNMV." /></a><div class="icnblk_cntnt" id="figlgndch38macularF25"><h4 id="ch38macular.F25"><a href="/books/NBK27323/figure/ch38macular.F25/?report=objectonly" target="object" rid-ob="figobch38macularF25">Figure 25. </a></h4><p class="float-caption no_bottom_margin">a) Subretinal hemorrhage and CNMV. b) Fluorescein angiogram demonstrates juxtafoveal CNVM in the transit phase. c) Fluorescein angiogram demonstrates late leakage from juxtafoveal CNVM. d) Dry laser scar 1 month after MPS style laser for juxtafoveal CNVM <a href="/books/NBK27323/figure/ch38macular.F25/?report=objectonly" target="object" rid-ob="figobch38macularF25">(more...)</a></p></div></div><p>In the late 1980's to mid-1990's there was significant interest in vitreoretinal surgical approaches to exudative AMD. Vitrectomy surgery with evacuation of subretinal blood and neovascular membranes reported variable success rates. Trial designs were nonstandard, results were conflicting, and long-term follow-up in these pilot trials was lacking. Given the potential morbidity and expense of major eye surgery, the National Eye Institute sponsored the prospective, randomized, controlled Submacular Surgery Trials (SST). The results of the trial demonstrated that surgery did not increase the chance of stable or improved vision, and it prevented severe vision loss only in those eyes with large subretinal hemorrhages. Submacular surgery was also associated with some risk of rhegmatogenous retinal detachment. Given these results, and the advent of less-invasive therapy with anti VEGF agents (described below) submacular surgery is no longer recommended for exudative AMD except, perhaps, in select cases with large submacular hemorrhage (<a class="bk_pop" href="#ch38macular.REF.45" data-bk-pop-others="ch38macular.REF.46">45, 46</a>).</p><p>Other surgical approaches, which have been investigated in small pilot trials, are macular translocation (Machemer and Steinhorst, 47), and limited macular translocation developed later by deJuan (<a class="bk_pop" href="#ch38macular.REF.48">48</a>). The former technique involves creation of a total retinal detachment, while the latter is limited to a partial retinal detachment. Both techniques involve displacement of the macular retina from an area of CNV to a location where the retinal pigment epithelium is thought to be healthier. While pilot trials have suggested a benefit from these therapies for a small subset of patients, the emergence of less invasive and more broadly applicable pharmacological therapies for exudative AMD have resulted in much less frequent application of macular translocation in recent years (<a class="figpopup" href="/books/NBK27323/figure/ch38macular.F26/?report=objectonly" target="object" rid-figpopup="figch38macularF26" rid-ob="figobch38macularF26">Figs. 26</a>-<a class="figpopup" href="/books/NBK27323/figure/ch38macular.F27/?report=objectonly" target="object" rid-figpopup="figch38macularF27" rid-ob="figobch38macularF27">maculardegen.F27</a><a class="figpopup" href="/books/NBK27323/figure/ch38macular.F28/?report=objectonly" target="object" rid-figpopup="figch38macularF28" rid-ob="figobch38macularF28">28</a>).</p><div class="iconblock whole_rhythm clearfix ten_col fig" id="figch38macularF26" co-legend-rid="figlgndch38macularF26"><a href="/books/NBK27323/figure/ch38macular.F26/?report=objectonly" target="object" title="Figure 26. " class="img_link icnblk_img figpopup" rid-figpopup="figch38macularF26" rid-ob="figobch38macularF26"><img class="small-thumb" src="/books/NBK27323/bin/ch38macular-Image027.gif" src-large="/books/NBK27323/bin/ch38macular-Image027.jpg" alt="Figure 26. . a ) pre-operative color photo of subfoveal CNVM just inferior to prior laser scar." /></a><div class="icnblk_cntnt" id="figlgndch38macularF26"><h4 id="ch38macular.F26"><a href="/books/NBK27323/figure/ch38macular.F26/?report=objectonly" target="object" rid-ob="figobch38macularF26">Figure 26. </a></h4><p class="float-caption no_bottom_margin">a ) pre-operative color photo of subfoveal CNVM just inferior to prior laser scar. b) preoperative angiogram demonstrating a large, classic subfoveal CNVM (photos from KMG files). </p></div></div><div class="iconblock whole_rhythm clearfix ten_col fig" id="figch38macularF27" co-legend-rid="figlgndch38macularF27"><a href="/books/NBK27323/figure/ch38macular.F27/?report=objectonly" target="object" title="Figure 27. " class="img_link icnblk_img figpopup" rid-figpopup="figch38macularF27" rid-ob="figobch38macularF27"><img class="small-thumb" src="/books/NBK27323/bin/ch38macular-Image028.gif" src-large="/books/NBK27323/bin/ch38macular-Image028.jpg" alt="Figure 27. . a) 4 day post-operative appearance after limited macular translocation (note air-bubble still present in the eye and superotemporal arcade has been displaced more superiorly than preoperatively)." /></a><div class="icnblk_cntnt" id="figlgndch38macularF27"><h4 id="ch38macular.F27"><a href="/books/NBK27323/figure/ch38macular.F27/?report=objectonly" target="object" rid-ob="figobch38macularF27">Figure 27. </a></h4><p class="float-caption no_bottom_margin">a) 4 day post-operative appearance after limited macular translocation (note air-bubble still present in the eye and superotemporal arcade has been displaced more superiorly than preoperatively). b) 4 day post-operative angiogram demonstrating previously <a href="/books/NBK27323/figure/ch38macular.F27/?report=objectonly" target="object" rid-ob="figobch38macularF27">(more...)</a></p></div></div><div class="iconblock whole_rhythm clearfix ten_col fig" id="figch38macularF28" co-legend-rid="figlgndch38macularF28"><a href="/books/NBK27323/figure/ch38macular.F28/?report=objectonly" target="object" title="Figure 28. " class="img_link icnblk_img figpopup" rid-figpopup="figch38macularF28" rid-ob="figobch38macularF28"><img class="small-thumb" src="/books/NBK27323/bin/ch38macular-Image029.gif" src-large="/books/NBK27323/bin/ch38macular-Image029.jpg" alt="Figure 28. . Color photo 4 months after macular translocation and subsequent laser of CNVM." /></a><div class="icnblk_cntnt" id="figlgndch38macularF28"><h4 id="ch38macular.F28"><a href="/books/NBK27323/figure/ch38macular.F28/?report=objectonly" target="object" rid-ob="figobch38macularF28">Figure 28. </a></h4><p class="float-caption no_bottom_margin">Color photo 4 months after macular translocation and subsequent laser of CNVM. Vision improved from 20/80 preoperatively to 20/40. Unfortunately the CNVM recurred subfoveally with a chorioretinal anastamosis by 9 months post-operatively (photo from KMG <a href="/books/NBK27323/figure/ch38macular.F28/?report=objectonly" target="object" rid-ob="figobch38macularF28">(more...)</a></p></div></div><p>In 2000, photodynamic therapy with Visudyne (tm) (verteporfin), a light-activated compound, was approved by the FDA for exudative AMD with predominately (>50%) classic, subfoveal CNV that was no larger than 5600 microns in diameter. FDA approval was based on the results of the Treatment of Age-Related Macular Degeneration with Photodynamic Therapy Investigation (TAP) study. In the TAP study, subfoveal CNV was divided into subgroups based on initial visual acuity, lesion size, and fluorescein leakage characteristics: enrolled subjects were randomized to Visudyne(tm) or placebo (<a class="bk_pop" href="#ch38macular.REF.49">49</a>). Photodynamic therapy (PDT) involves intravenous administration of the photoactivatable compound, Visudyne (tm) followed 15 minutes later by irradiation of the CNV with a low energy, non-thermal laser. Activated Visudyne(tm) generates singlet oxygen that damages the CNV endothelium resulting in thrombosis (<a class="bk_pop" href="#ch38macular.REF.50">50</a>). In the TAP study an average of 3.5 treatments spaced at three month intervals were required to ablate the CNV, so the process is a lengthy one. Visual results, though better than with any prior treatment, were less than optimal with only 67% of treated patients with predominately classic CNV losing fewer than three lines of visual acuity (as compared to 39% of placebo treated eyes). At 1 year, 16% of Visudyne treated patients gained one or more line of vision, and 15% of treated patients lost more than six lines of visual acuity. Over the course of the next several years, subgroup analysis of data from the TAP studies as well as additional trials with Visudyne(tm) treatment for lesions other than predominately classic CNV led to its application for other lesion types. However, the visual results for lesions that were predominantly occult CNV were less favorable than those with predominately classic CNV (<a class="bk_pop" href="#ch38macular.REF.51" data-bk-pop-others="ch38macular.REF.52">51, 52</a>).</p><p><a class="figpopup" href="/books/NBK27323/figure/ch38macular.F29/?report=objectonly" target="object" rid-figpopup="figch38macularF29" rid-ob="figobch38macularF29">Figs. 29</a>-<a class="figpopup" href="/books/NBK27323/figure/ch38macular.F30/?report=objectonly" target="object" rid-figpopup="figch38macularF30" rid-ob="figobch38macularF30">maculardegen.F30</a><a class="figpopup" href="/books/NBK27323/figure/ch38macular.F31/?report=objectonly" target="object" rid-figpopup="figch38macularF31" rid-ob="figobch38macularF31">maculardegen.F31</a><a class="figpopup" href="/books/NBK27323/figure/ch38macular.F32/?report=objectonly" target="object" rid-figpopup="figch38macularF32" rid-ob="figobch38macularF32">32</a> demonstrate a favorable response to PDT with Visudyne as seen in our clinic.</p><div class="iconblock whole_rhythm clearfix ten_col fig" id="figch38macularF29" co-legend-rid="figlgndch38macularF29"><a href="/books/NBK27323/figure/ch38macular.F29/?report=objectonly" target="object" title="Figure 29. " class="img_link icnblk_img figpopup" rid-figpopup="figch38macularF29" rid-ob="figobch38macularF29"><img class="small-thumb" src="/books/NBK27323/bin/ch38macular-Image030.gif" src-large="/books/NBK27323/bin/ch38macular-Image030.jpg" alt="Figure 29. . Color photo of subfoveal CNVM adjacent to an area of geographic atrophy ." /></a><div class="icnblk_cntnt" id="figlgndch38macularF29"><h4 id="ch38macular.F29"><a href="/books/NBK27323/figure/ch38macular.F29/?report=objectonly" target="object" rid-ob="figobch38macularF29">Figure 29. </a></h4><p class="float-caption no_bottom_margin">Color photo of subfoveal CNVM adjacent to an area of geographic atrophy . </p></div></div><div class="iconblock whole_rhythm clearfix ten_col fig" id="figch38macularF30" co-legend-rid="figlgndch38macularF30"><a href="/books/NBK27323/figure/ch38macular.F30/?report=objectonly" target="object" title="Figure 30. " class="img_link icnblk_img figpopup" rid-figpopup="figch38macularF30" rid-ob="figobch38macularF30"><img class="small-thumb" src="/books/NBK27323/bin/ch38macular-Image031.gif" src-large="/books/NBK27323/bin/ch38macular-Image031.jpg" alt="Figure 30. . Angiogram demonstrating predominately classic subfoveal CNVM adjacent to an area of geographic atrophy." /></a><div class="icnblk_cntnt" id="figlgndch38macularF30"><h4 id="ch38macular.F30"><a href="/books/NBK27323/figure/ch38macular.F30/?report=objectonly" target="object" rid-ob="figobch38macularF30">Figure 30. </a></h4><p class="float-caption no_bottom_margin">Angiogram demonstrating predominately classic subfoveal CNVM adjacent to an area of geographic atrophy. </p></div></div><div class="iconblock whole_rhythm clearfix ten_col fig" id="figch38macularF31" co-legend-rid="figlgndch38macularF31"><a href="/books/NBK27323/figure/ch38macular.F31/?report=objectonly" target="object" title="Figure 31. " class="img_link icnblk_img figpopup" rid-figpopup="figch38macularF31" rid-ob="figobch38macularF31"><img class="small-thumb" src="/books/NBK27323/bin/ch38macular-Image032.gif" src-large="/books/NBK27323/bin/ch38macular-Image032.jpg" alt="Figure 31. . Late phase angiogram of predominately classic subfoveal CNVM with superimposed greatest linear diameter (GLD) and PDT treatment guide." /></a><div class="icnblk_cntnt" id="figlgndch38macularF31"><h4 id="ch38macular.F31"><a href="/books/NBK27323/figure/ch38macular.F31/?report=objectonly" target="object" rid-ob="figobch38macularF31">Figure 31. </a></h4><p class="float-caption no_bottom_margin">Late phase angiogram of predominately classic subfoveal CNVM with superimposed greatest linear diameter (GLD) and PDT treatment guide. </p></div></div><div class="iconblock whole_rhythm clearfix ten_col fig" id="figch38macularF32" co-legend-rid="figlgndch38macularF32"><a href="/books/NBK27323/figure/ch38macular.F32/?report=objectonly" target="object" title="Figure 32. " class="img_link icnblk_img figpopup" rid-figpopup="figch38macularF32" rid-ob="figobch38macularF32"><img class="small-thumb" src="/books/NBK27323/bin/ch38macular-Image033.gif" src-large="/books/NBK27323/bin/ch38macular-Image033.jpg" alt="Figure 32. . Post-PDT treatment for subfoveal CNVM without evidence of recurrence or significant and retention of good vision at 3 months after the last PDT treatment." /></a><div class="icnblk_cntnt" id="figlgndch38macularF32"><h4 id="ch38macular.F32"><a href="/books/NBK27323/figure/ch38macular.F32/?report=objectonly" target="object" rid-ob="figobch38macularF32">Figure 32. </a></h4><p class="float-caption no_bottom_margin">Post-PDT treatment for subfoveal CNVM without evidence of recurrence or significant and retention of good vision at 3 months after the last PDT treatment. </p></div></div><p>As noted above, however, not all eyes fare well with PDT therapy. Below is a photograph of an eye that did not demonstrate a significant benefit from PDT treatment with Visudyne (<a class="figpopup" href="/books/NBK27323/figure/ch38macular.F33/?report=objectonly" target="object" rid-figpopup="figch38macularF33" rid-ob="figobch38macularF33">Fig. 33</a>).</p><div class="iconblock whole_rhythm clearfix ten_col fig" id="figch38macularF33" co-legend-rid="figlgndch38macularF33"><a href="/books/NBK27323/figure/ch38macular.F33/?report=objectonly" target="object" title="Figure 33. " class="img_link icnblk_img figpopup" rid-figpopup="figch38macularF33" rid-ob="figobch38macularF33"><img class="small-thumb" src="/books/NBK27323/bin/ch38macular-Image034.gif" src-large="/books/NBK27323/bin/ch38macular-Image034.jpg" alt="Figure 33. . Example of an eye which developed disciform scarring after PDT (photo from KMG files)." /></a><div class="icnblk_cntnt" id="figlgndch38macularF33"><h4 id="ch38macular.F33"><a href="/books/NBK27323/figure/ch38macular.F33/?report=objectonly" target="object" rid-ob="figobch38macularF33">Figure 33. </a></h4><p class="float-caption no_bottom_margin">Example of an eye which developed disciform scarring after PDT (photo from KMG files). </p></div></div><p>Other ablative treatments for CNV include transpupillary thermotherapy (TTT) and radiation therapy. TTT utilizes low energy diode laser (810 nm) applied to the CNV slowly over one minute. Small pilot trials of TTT for occult CNV initially showed promise but a randomized, prospective clinical trial (TTT4 CNV) demonstrated no significant benefit. Similarly, low dose radiation therapy for AMD was investigated in multiple small pilot trials with conflicting results (<a class="bk_pop" href="#ch38macular.REF.53" data-bk-pop-others="ch38macular.REF.54 ch38macular.REF.55">53-55</a>). Although no definitive prospective clinical trial of radiation therapy for AMD has ever been conducted, the concept has become less popular in recent years, especially in light of the interest in pharmacological therapies for AMD.</p><p>The current era of therapy for exudative AMD utilizes administration of anti-neovascular agents periocularly or intraocularly. Studies implicating various cellular growth factors, including vascular endothelial growth factor (VEGF) in a variety of ocular neovascular processes has led to the development of VEGF inhibitors, VEGF antibodies and other "broad-spectrum" antiangiogenic molecules that inhibit pro-angiogenic cytokines. In 2004, Macugen(tm) (Pegantanib Sodium) was the first of the VEGF inhibitors to be approved by the FDA for exudative AMD. Macugen is an aptamer which binds to the A isoform of VEGF-165 at its heparin binding site and prevents VEGF-165 from binding to its receptor on endothelial cells. Macugen is administered by intravitreal injection (i.e. injected into the vitreous cavity of the eye) every 6 weeks for up to a two-year course of therapy. Based on the Macugen (tm) study results of 1186 patients after one-year, 70% of subjects treated with 0.3 mg pegaptanib, 70% lost fewer than 3 lines of vision compared to 55% of controls. The risk of severe vision loss (> 6 lines of vision) was reduced from 22% in controls to 10% in treated subjects (<a class="bk_pop" href="#ch38macular.REF.56">56</a>).</p><p>Another VEGF inhibitor undergoing clinical trials is ranibizumab or Lucentis(tm). Lucentis(tm) is derived from the Fab fragment of an antibody to isoform A of VEGF. The fragment blocks VEGF binding to its receptor on endothelial cells, thus inhibiting its biological activity. The ANCHOR trial was presented recently (<a class="bk_pop" href="#ch38macular.REF.57">57</a>). The data demonstrated not only a preservation of vision in nearly 95% of patients treated with Lucentis(tm) (ranibizumab) at year one but, for the first time, an improvement in vision in 30-38% of patients with exudative AMD. Another recently published trial comparing Lucentis alone to PDT alone demonstrated superior visual results with Lucentis. (ref: Anchor Trial). Lucentis(tm) was FDA approved for the treatment of exudative AMD in June 2006. Although the initial trials with Lucentis utilized monthly intravitreal injection with the drug, more recent studies indicate that some patients my respond favorably to a treatment regimen utilizing fewer than 24 injections over a 2 year period (Fung et al., 2007) (<a class="bk_pop" href="#ch38macular.REF.248">248</a>). Currently, studies are underway to determine factors which might influence frequency and duration of treatment with Lucentis.</p><p>Avastin(tm) (beclumizabab), a VEGF antibody derived from the same parent antibody as Lucentis(tm), is approved by the FDA to treat colon cancer and is gaining popularity as an "off-label" intravitreal therapy for AMD. It is important to note that Avastin(tm) has not yet undergone the toxicity studies and controlled trials that are required by the FDA for ocular application (<a class="bk_pop" href="#ch38macular.REF.58" data-bk-pop-others="ch38macular.REF.59">58, 59</a>). Other anti-angiogenic therapies currently under study include anecortave acetate (Retane, an antiangiogenic steroid (<a class="bk_pop" href="#ch38macular.REF.60">60, 61</a>)), squalene and triamcinolone (which carries a significant risk of causing cataract and steroid-induced glaucoma). Additional studies are underway to investigate the potential for a combination of Anti-VEGF therapy with Visudyne(tm) photodynamic therapy utilizing light doses lower than those applied in the TAP an VIP studies with Visudyne (<a class="bk_pop" href="#ch38macular.REF.62" data-bk-pop-others="ch38macular.REF.63 ch38macular.REF.249">62, 63, 249</a>).</p><p><a class="figpopup" href="/books/NBK27323/figure/ch38macular.F34/?report=objectonly" target="object" rid-figpopup="figch38macularF34" rid-ob="figobch38macularF34">Figures 34</a> and <a class="figpopup" href="/books/NBK27323/figure/ch38macular.F35/?report=objectonly" target="object" rid-figpopup="figch38macularF35" rid-ob="figobch38macularF35">35</a> show results of pre (<a class="figpopup" href="/books/NBK27323/figure/ch38macular.F34/?report=objectonly" target="object" rid-figpopup="figch38macularF34" rid-ob="figobch38macularF34">Fig. 34</a>, <a class="figpopup" href="/books/NBK27323/figure/ch38macular.F35/?report=objectonly" target="object" rid-figpopup="figch38macularF35" rid-ob="figobch38macularF35">Fig. 35</a>) and post anti-VEGF treatment (<a class="figpopup" href="/books/NBK27323/figure/ch38macular.F36/?report=objectonly" target="object" rid-figpopup="figch38macularF36" rid-ob="figobch38macularF36">Fig. 36</a>).</p><div class="iconblock whole_rhythm clearfix ten_col fig" id="figch38macularF34" co-legend-rid="figlgndch38macularF34"><a href="/books/NBK27323/figure/ch38macular.F34/?report=objectonly" target="object" title="Figure 34. " class="img_link icnblk_img figpopup" rid-figpopup="figch38macularF34" rid-ob="figobch38macularF34"><img class="small-thumb" src="/books/NBK27323/bin/ch38macular-Image035.gif" src-large="/books/NBK27323/bin/ch38macular-Image035.jpg" alt="Figure 34. . Color photo of subfoveal CNVM and hemorrhage due to AMD (photo from KMG files)." /></a><div class="icnblk_cntnt" id="figlgndch38macularF34"><h4 id="ch38macular.F34"><a href="/books/NBK27323/figure/ch38macular.F34/?report=objectonly" target="object" rid-ob="figobch38macularF34">Figure 34. </a></h4><p class="float-caption no_bottom_margin">Color photo of subfoveal CNVM and hemorrhage due to AMD (photo from KMG files). </p></div></div><div class="iconblock whole_rhythm clearfix ten_col fig" id="figch38macularF35" co-legend-rid="figlgndch38macularF35"><a href="/books/NBK27323/figure/ch38macular.F35/?report=objectonly" target="object" title="Figure 35. " class="img_link icnblk_img figpopup" rid-figpopup="figch38macularF35" rid-ob="figobch38macularF35"><img class="small-thumb" src="/books/NBK27323/bin/ch38macular-Image036.gif" src-large="/books/NBK27323/bin/ch38macular-Image036.jpg" alt="Figure 35. . Above: Early and late phase angiogram of subfoveal, predominately occult CNVM due to AMD (photo from KMG files)." /></a><div class="icnblk_cntnt" id="figlgndch38macularF35"><h4 id="ch38macular.F35"><a href="/books/NBK27323/figure/ch38macular.F35/?report=objectonly" target="object" rid-ob="figobch38macularF35">Figure 35. </a></h4><p class="float-caption no_bottom_margin">Above: Early and late phase angiogram of subfoveal, predominately occult CNVM due to AMD (photo from KMG files). </p></div></div><div class="iconblock whole_rhythm clearfix ten_col fig" id="figch38macularF36" co-legend-rid="figlgndch38macularF36"><a href="/books/NBK27323/figure/ch38macular.F36/?report=objectonly" target="object" title="Figure 36. " class="img_link icnblk_img figpopup" rid-figpopup="figch38macularF36" rid-ob="figobch38macularF36"><img class="small-thumb" src="/books/NBK27323/bin/ch38macular-Image037.gif" src-large="/books/NBK27323/bin/ch38macular-Image037.jpg" alt="Figure 36. . a) Horizontal OCT scan throught the foveal region of subfoveal CNV seen in the photos above before anti-VEGF therapy." /></a><div class="icnblk_cntnt" id="figlgndch38macularF36"><h4 id="ch38macular.F36"><a href="/books/NBK27323/figure/ch38macular.F36/?report=objectonly" target="object" rid-ob="figobch38macularF36">Figure 36. </a></h4><p class="float-caption no_bottom_margin">a) Horizontal OCT scan throught the foveal region of subfoveal CNV seen in the photos above before anti-VEGF therapy. b) Horizontal OCT scan throught the fovea after multiple injections with anti-VEGF therapy (both bevicizumab and ranibizumab). c) : Horizontal <a href="/books/NBK27323/figure/ch38macular.F36/?report=objectonly" target="object" rid-ob="figobch38macularF36">(more...)</a></p></div></div><p>As a result of the anti-VEGF treatment much improvement can be seen in the macular area along with good visual restoration. The OCT scans (<a class="figpopup" href="/books/NBK27323/figure/ch38macular.F36/?report=objectonly" target="object" rid-figpopup="figch38macularF36" rid-ob="figobch38macularF36">Fig. 36</a>) show filling in of the disrupted cell types in the retina (the holes of <a class="figpopup" href="/books/NBK27323/figure/ch38macular.F36/?report=objectonly" target="object" rid-figpopup="figch38macularF36" rid-ob="figobch38macularF36">Fig 36a</a> get occupied by cells) and glial cells react to restore damaged retina (<a class="figpopup" href="/books/NBK27323/figure/ch38macular.F36/?report=objectonly" target="object" rid-figpopup="figch38macularF36" rid-ob="figobch38macularF36">Fig. 36b</a> and <a class="figpopup" href="/books/NBK27323/figure/ch38macular.F36/?report=objectonly" target="object" rid-figpopup="figch38macularF36" rid-ob="figobch38macularF36">Fig. 36c</a>, green upward streaks).</p><p>One concern with all anti-angiogenic agents is their potential for systemic inhibition of VEGF that may produce cardiovascular or cerebrovascular complications, or inhibit wound healing. The immediate and long-term systemic effects of these drugs, especially those prescribed "off-label", are largely unknown and difficult to determine in an elderly population already prone to vascular events. Additional drawbacks to the intravitreally administered therapeutics include patient discomfort, intraocular infection (endophthalmitis), retinal tear or detachment, and lens damage in phakic patients (<a class="bk_pop" href="#ch38macular.REF.64">64</a>). The incidence of endophthalmitis in published trials with Macugen and Lucentis were 0.16%/injection and 1.3% - 1.4% of patients respectively and the incidence of retinal tears and/or detachment in these studies were 0.08%/injection and 0% - 0.4% respectively. (see Macugen and Lucentis trials refs below) Risk of lens damage in phakic patients treated with intravitreal anti-VEGF therapy can be minimized by visualization of the needle tip with the indirect ophthalmoscope during injection and by proper patient preparation (anesthetic, education, and reassurance) during the injection process to minimize the risk of sudden patient movement. Some patients do quite well with topical anesthetic alone while others require subconjunctival anesthetic injection (<a class="bk_pop" href="#ch38macular.REF.249" data-bk-pop-others="ch38macular.REF.250 ch38macular.REF.251">249-251</a>).</p><p>Recent discoveries of the role that inflammation plays in AMD pathogenesis (see above) has led to an interest in investigating the anti-inflammatory effects of statins on AMD. Several clinical population-based studies of the effects of statins on AMD development and progression have yielded conflicting results (<a class="bk_pop" href="#ch38macular.REF.65">65</a>). Thus, more studies in this area will be required to assess efficacy.</p><p>In the near future, therapy for exudative AMD will likely involve multiple anti-neovascular agents, possibly coupled with less frequent application of photodynamic therapy, in order to maximize the beneficial effects of each and minimize the frequency of adverse side effects. Further on the horizon are anti-angiogenic agents in longer acting forms that require less frequent administration. The ultimate therapy for AMD, however, will lie in preclinical identification of those who are genetically "at risk" for the disease, coupled with preventative strategies that are designed to minimize or compensate for one's genetic predisposition.</p></div><div id="ch38macular.Conclusion"><h2 id="_ch38macular_Conclusion_">Conclusion</h2><p>Complement Factor H is the first gene identified in multiple independent studies that confers a significant risk for the development of AMD. This finding, together with the subsequent identification of AMD-associated variants in the related complement genes BF and C2, provide compelling evidence that the innate immune system and, more specifically, uncontrolled regulation of the alternative pathway of complement, plays a central role in the pathobiology of AMD. At this point, the most likely scenario is that exposure to infection or some other triggering event in genetically susceptible individuals, coupled with impaired complement regulatory function leads to the sustained activation of complement cascade, drusen formation and, eventually, development of AMD.</p><p>The emergence of this new paradigm of AMD pathogenesis sets the stage for the rapid development of early diagnostics, novel bioassays, and new animal models that faithfully mimic aspects of the disease process. Furthermore, the way is now paved for development of novel therapeutic interventions aimed at modulating the alternative pathway of complement in "at risk" individuals prior to the onset of choroidal neovascularization or geographic atrophy.</p><p>Now that the genetic basis for a major proportion of AMD cases has been elucidated, what additional scientific progress may be anticipated, and what will be the significance of these new findings for the diagnosis and treatment of AMD? In the near term, a more comprehensive understanding of the genetic basis of AMD should rapidly emerge. It will not be surprising, for example, if genetic polymorphisms in additional complement components, complement regulators and, possibly, immune system effectors and inflammatory mediators are implicated in AMD. Secondly, it may be anticipated that the gene variants linked to AMD also contribute to other prevalent age-related diseases where chronic, local inflammatory processes are involved. For example, a significant statistical relationship between the CFH Tyr402His "risk" variant and the incidence of myocardial infarction has recently been reported (<a class="bk_pop" href="#ch38macular.REF.243" data-bk-pop-others="ch38macular.REF.245 ch38macular.REF.246">243, 245, 246</a>). Based upon this new genetic information, it will be possible to devise genetic screening tests that will identify those individuals who are most at risk of developing AMD later in life. This will enable clinicians to monitor susceptible individuals from an early age, and to develop and test new preventive treatments in the early stages of the disease. Finally, the development of new diagnostic and pharmacological approaches will be hastened by the identification of the alternative pathway of complement as a prime therapeutic target. As our understanding of the pathogenesis of AMD continues to improve, so does the prospects for new diagnostic and therapeutic approaches. Hopefully, we will eventually eradicate AMD and dramatically improve the quality of life in our older generation.</p></div><div id="ch38macular.The_Author"><h2 id="_ch38macular_The_Author_">The Author</h2><div id="f1123" class="figure"><div class="graphic"><img src="/books/NBK27323/bin/ch38macular-Image001.jpg" alt="Image ch38macular-Image001" /></div></div><p>Gregory S. Hageman, Ph.D., is a John A. Moran Presidential Professor of Ophthalmology and Visual Sciences, and Director of the Moran Center for Translational Medicine at the University of Utah. He is a graduate of the University of Southern California, where he conducted both his undergraduate and graduate studies in biology and marine biology. Most of his previous research career was at the Iowa Carver College of Medicine and his primary research interests have always been assessment of pathways involved in the etiology of age-related macular degeneration (AMD). Dr. Hageman is an active member of various professional and honorary organizations including the Macula Society and has also served on a number of national and international advisory boards, service panels and review committee. Moreover, he serves or has served as an advisor to Genentech, Alcon, Pfizer, OccuLogix, Novartis, Tanox and American Home Products. Dr. Hageman is an author or co-author of more than 100 refereed and invited publications, as well as multiple issued patents and pending patent applications. He was recently invited to present his research findings to Congress. He received the Trustee Award from Foundation Fighting Blindness, the Roger Johnson Prize for Macular Degeneration.</p></div><div id="ch38macular.References"><h2 id="_ch38macular_References_">References</h2><dl class="temp-labeled-list"><dt>1.</dt><dd><div class="bk_ref" id="ch38macular.REF.1">Uhlmann RF, Larson EB, Koepsell TD, Rees TS, Duckert LG. 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[<a href="https://pubmed.ncbi.nlm.nih.gov/16647134" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 16647134</span></a>]</div></dd><dt>250.</dt><dd><div class="bk_ref" id="ch38macular.REF.250">Brown DM, Kaiser PK, Michels M, Soubrane G, Heier JS, Kim RY, Sy JP, Schneider S., ANCHOR Study Group. Ranibizumab versus verteporfin for neovascular age-related macular degeneration. <span><span class="ref-journal">N Engl J Med. </span>2006;<span class="ref-vol">355</span>(14):1432–44.</span> PubMed. [<a href="https://pubmed.ncbi.nlm.nih.gov/17021319" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 17021319</span></a>]</div></dd><dt>251.</dt><dd><div class="bk_ref" id="ch38macular.REF.251">Rosenfeld PJ, Brown DM, Heier JS, Boyer DS, Kaiser PK, Chung CY, Kim RY., MARINA Study Group. Ranibizumab for neovascular age-related macular degeneration. <span><span class="ref-journal">N Engl J Med. </span>2006;<span class="ref-vol">355</span>(14):1419–3.</span> PubMed. [<a href="https://pubmed.ncbi.nlm.nih.gov/17021318" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 17021318</span></a>]</div></dd></dl></div><div id="bk_toc_contnr"></div></div></div>
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<div class="post-content"><div><div class="half_rhythm"><a href="/books/about/copyright/">Copyright</a>: © 2025 Webvision .<p class="small">All copyright for chapters belongs to the individual authors who created them. However, for non-commercial, academic purposes, images and content from the chapters portion of Webvision may be used with a non-exclusive rights under a Attribution, <a href="https://creativecommons.org/licenses/by-nc/4.0/" ref="pagearea=meta&targetsite=external&targetcat=link&targettype=uri">Noncommercial 4.0 International (CC BY-NC) Creative Commons license</a>. Cite Webvision, http://webvision.med.utah.edu/ as the source. Commercial applications need to obtain license permission from the administrator of Webvision and are generally declined unless the copyright owner can/wants to donate or license material. Use online should be accompanied by a link back to the original source of the material. All imagery or content associated with blog posts belong to the authors of said posts, except where otherwise noted.</p></div><div class="small"><span class="label">Bookshelf ID: NBK27323</span><span class="label">PMID: <a href="https://pubmed.ncbi.nlm.nih.gov/21413412" title="PubMed record of this page" ref="pagearea=meta&targetsite=entrez&targetcat=link&targettype=pubmed">21413412</a></span></div><div style="margin-top:2em" class="bk_noprnt"><a class="bk_cntns" href="/books/n/webvision/">Contents</a><div class="pagination bk_noprnt"><a class="active page_link prev" href="/books/n/webvision/ch37fisher/" title="Previous page in this title">< Prev</a><a class="active page_link next" href="/books/n/webvision/ArdenRetinopathy/" title="Next page in this title">Next ></a></div></div></div></div>
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<div xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"></div><div class="portlet"><div class="portlet_head"><div class="portlet_title"><h3><span>Views</span></h3></div><a name="Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="PDF_download" id="Shutter"></a></div><div class="portlet_content"><ul xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="simple-list"><li><a href="/books/NBK27323/?report=reader">PubReader</a></li><li><a href="/books/NBK27323/?report=printable">Print View</a></li><li><a data-jig="ncbidialog" href="#_ncbi_dlg_citbx_NBK27323" data-jigconfig="width:400,modal:true">Cite this Page</a><div id="_ncbi_dlg_citbx_NBK27323" style="display:none" title="Cite this Page"><div class="bk_tt">Hageman GS, Gehrs K, Johnson LV, et al. Age-Related Macular Degeneration (AMD) 2008 Jan 1. In: Kolb H, Fernandez E, Jones B, et al., editors. Webvision: The Organization of the Retina and Visual System [Internet]. Salt Lake City (UT): University of Utah Health Sciences Center; 1995-. <span class="bk_cite_avail"></span></div></div></li><li><a href="/books/NBK27323/pdf/Bookshelf_NBK27323.pdf">PDF version of this page</a> (3.4M)</li><li><a href="/books/n/webvision/pdf/">PDF version of this title</a> (235M)</li></ul></div></div><div class="portlet"><div class="portlet_head"><div class="portlet_title"><h3><span>In this Page</span></h3></div><a name="Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="page-toc" id="Shutter"></a></div><div class="portlet_content"><ul xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="simple-list"><li><a href="#ch38macular.Introduction" ref="log$=inpage&link_id=inpage">Introduction</a></li><li><a href="#ch38macular.Clinical_Aspects_of_AMD" ref="log$=inpage&link_id=inpage">Clinical Aspects of AMD</a></li><li><a href="#ch38macular.Pathology_of_AMD" ref="log$=inpage&link_id=inpage">Pathology of AMD</a></li><li><a href="#ch38macular.Physiology_of_early_AMD" ref="log$=inpage&link_id=inpage">Physiology of early AMD</a></li><li><a href="#ch38macular.Inflammation_and_AMD" ref="log$=inpage&link_id=inpage">Inflammation and AMD</a></li><li><a href="#ch38macular.The_Complement_System_and_AM" ref="log$=inpage&link_id=inpage">The Complement System and AMD</a></li><li><a href="#ch38macular.Molecular_genetics_of_AMD" ref="log$=inpage&link_id=inpage">Molecular genetics of AMD</a></li><li><a href="#ch38macular.Therapy_for_AMD" ref="log$=inpage&link_id=inpage">Therapy for AMD</a></li><li><a href="#ch38macular.Conclusion" ref="log$=inpage&link_id=inpage">Conclusion</a></li><li><a href="#ch38macular.The_Author" ref="log$=inpage&link_id=inpage">The Author</a></li><li><a href="#ch38macular.References" ref="log$=inpage&link_id=inpage">References</a></li></ul></div></div><div class="portlet"><div class="portlet_head"><div 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