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<meta name="robots" content="INDEX,FOLLOW,NOARCHIVE,NOIMAGEINDEX" /><meta name="author" content="Andreas Goebel, Jatinder Bisla, Roy Carganillo, Claire Cole, Bernhard Frank, Rima Gupta, Mairi James, Joanna Kelly, Candy McCabe, Holly Milligan, Caroline Murphy, Nick Padfield, Ceri Phillips, Helen Poole, Mark Saunders, Mick Serpell, Nick Shenker, Karim Shoukrey, Lynne Wyatt, Gareth Ambler" /><meta name="citation_title" content="A randomised placebo-controlled Phase III multicentre trial: low-dose intravenous immunoglobulin treatment for long-standing complex regional pain syndrome (LIPS trial)" /><meta name="citation_publisher" content="NIHR Journals Library" /><meta name="citation_date" content="2017/11" /><meta name="citation_author" content="Andreas Goebel" /><meta name="citation_author" content="Jatinder Bisla" /><meta name="citation_author" content="Roy Carganillo" /><meta name="citation_author" content="Claire Cole" /><meta name="citation_author" content="Bernhard Frank" /><meta 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content="https://www.ncbi.nlm.nih.gov/books/NBK464478/" /><meta name="citation_keywords" content="RANDOMISED CONTROLLED TRIAL" /><meta name="citation_keywords" content="INTRAVENOUS IMMUNOGLOBULIN" /><meta name="citation_keywords" content="COMPLEX REGIONAL PAIN SYNDROME" /><link rel="schema.DC" href="http://purl.org/DC/elements/1.0/" /><meta name="DC.Title" content="A randomised placebo-controlled Phase III multicentre trial: low-dose intravenous immunoglobulin treatment for long-standing complex regional pain syndrome (LIPS trial)" /><meta name="DC.Type" content="Text" /><meta name="DC.Publisher" content="NIHR Journals Library" /><meta name="DC.Contributor" content="Andreas Goebel" /><meta name="DC.Contributor" content="Jatinder Bisla" /><meta name="DC.Contributor" content="Roy Carganillo" /><meta name="DC.Contributor" content="Claire Cole" /><meta name="DC.Contributor" content="Bernhard Frank" /><meta name="DC.Contributor" content="Rima Gupta" /><meta name="DC.Contributor" content="Mairi James" /><meta name="DC.Contributor" content="Joanna Kelly" /><meta name="DC.Contributor" content="Candy McCabe" /><meta name="DC.Contributor" content="Holly Milligan" /><meta name="DC.Contributor" content="Caroline Murphy" /><meta name="DC.Contributor" content="Nick Padfield" /><meta name="DC.Contributor" content="Ceri Phillips" /><meta name="DC.Contributor" content="Helen Poole" /><meta name="DC.Contributor" content="Mark Saunders" /><meta name="DC.Contributor" content="Mick Serpell" /><meta name="DC.Contributor" content="Nick Shenker" /><meta name="DC.Contributor" content="Karim Shoukrey" /><meta name="DC.Contributor" content="Lynne Wyatt" /><meta name="DC.Contributor" content="Gareth Ambler" /><meta name="DC.Date" content="2017/11" /><meta name="DC.Identifier" content="https://www.ncbi.nlm.nih.gov/books/NBK464478/" /><meta name="description" content="Low-dose intravenous immunoglobulin was not effective in relieving pain in longstanding complex regional pain 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<div class="pre-content"><div><div class="bk_prnt"><p class="small">NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.</p></div><div class="pagination bk_noprnt"><span class="inactive page_link prev">< Prev</span><a class="active page_link next" href="/books/n/ukeme0405/abs2/" title="Next page in this title">Next ></a></div></div></div>
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<div class="main-content lit-style" itemscope="itemscope" itemtype="http://schema.org/Book"><div class="meta-content fm-sec"><div class="iconblock whole_rhythm clearfix no_top_margin"><a href="http://www.journalslibrary.nihr.ac.uk/eme" title="NIHR Journals Library" class="img_link icnblk_img" ref="pagearea=logo&targetsite=external&targetcat=link&targettype=publisher"><img class="source-thumb" src="/corehtml/pmc/pmcgifs/bookshelf/thumbs/th-ukeme0405-lrg.png" alt="Cover of A randomised placebo-controlled Phase III multicentre trial: low-dose intravenous immunoglobulin treatment for long-standing complex regional pain syndrome (LIPS trial)" /></a><div class="icnblk_cntnt"><h1 id="_NBK464478_"><span itemprop="name">A randomised placebo-controlled Phase III multicentre trial: low-dose intravenous immunoglobulin treatment for long-standing complex regional pain syndrome (LIPS trial)</span></h1><p><i>Efficacy and Mechanism Evaluation, No. 4.5</i></p><p class="contrib-group"><span itemprop="author">Andreas Goebel</span>, <span itemprop="author">Jatinder Bisla</span>, <span itemprop="author">Roy Carganillo</span>, <span itemprop="author">Claire Cole</span>, <span itemprop="author">Bernhard Frank</span>, <span itemprop="author">Rima Gupta</span>, <span itemprop="author">Mairi James</span>, <span itemprop="author">Joanna Kelly</span>, <span itemprop="author">Candy McCabe</span>, <span itemprop="author">Holly Milligan</span>, <span itemprop="author">Caroline Murphy</span>, <span itemprop="author">Nick Padfield</span>, <span itemprop="author">Ceri Phillips</span>, <span itemprop="author">Helen Poole</span>, <span itemprop="author">Mark Saunders</span>, <span itemprop="author">Mick Serpell</span>, <span itemprop="author">Nick Shenker</span>, <span itemprop="author">Karim Shoukrey</span>, <span itemprop="author">Lynne Wyatt</span>, and <span itemprop="author">Gareth Ambler</span>.</p><a data-jig="ncbitoggler" href="#__NBK464478_ai__" style="border:0;text-decoration:none">Author Information and Affiliations</a><div style="display:none" class="ui-widget" id="__NBK464478_ai__"><p class="contrib-group"><h4>Authors</h4><span itemprop="author">Andreas Goebel</span>,<sup>1</sup><sup>,*</sup> <span itemprop="author">Jatinder Bisla</span>,<sup>2</sup> <span itemprop="author">Roy Carganillo</span>,<sup>3</sup> <span itemprop="author">Claire Cole</span>,<sup>1</sup> <span itemprop="author">Bernhard Frank</span>,<sup>4</sup> <span itemprop="author">Rima Gupta</span>,<sup>5</sup> <span itemprop="author">Mairi James</span>,<sup>6</sup> <span itemprop="author">Joanna Kelly</span>,<sup>2</sup> <span itemprop="author">Candy McCabe</span>,<sup>7,8</sup> <span itemprop="author">Holly Milligan</span>,<sup>1</sup> <span itemprop="author">Caroline Murphy</span>,<sup>2</sup> <span itemprop="author">Nick Padfield</span>,<sup>3</sup> <span itemprop="author">Ceri Phillips</span>,<sup>9</sup> <span itemprop="author">Helen Poole</span>,<sup>10</sup> <span itemprop="author">Mark Saunders</span>,<sup>11</sup> <span itemprop="author">Mick Serpell</span>,<sup>6</sup> <span itemprop="author">Nick Shenker</span>,<sup>12</sup> <span itemprop="author">Karim Shoukrey</span>,<sup>13</sup> <span itemprop="author">Lynne Wyatt</span>,<sup>4</sup> and <span itemprop="author">Gareth Ambler</span><sup>14</sup>.</p><h4>Affiliations</h4><div class="affiliation"><sup>1</sup> Pain Research Institute, Clinical Sciences Centre, Liverpool, UK</div><div class="affiliation"><sup>2</sup> King’s Clinical Trials Unit, Institute of Psychiatry, Psychology and Neuroscience, London, UK</div><div class="affiliation"><sup>3</sup> Pain Management and Neuromodulation Centre, Guy’s and St Thomas’ Hospital, London, UK</div><div class="affiliation"><sup>4</sup> The Walton Centre NHS Foundation Trust, Liverpool, UK</div><div class="affiliation"><sup>5</sup> Modepharma Ltd, Beckenham, UK</div><div class="affiliation"><sup>6</sup> University Department of Anaesthesia, Queen Elizabeth University Hospital, Glasgow Clinical Research Facility, Glasgow, UK,</div><div class="affiliation"><sup>7</sup> Royal National Hospital for Rheumatic Diseases, Bath, UK</div><div class="affiliation"><sup>8</sup> University of the West of England, Bristol, UK</div><div class="affiliation"><sup>9</sup> College of Human and Health Sciences, Swansea University, Swansea, UK</div><div class="affiliation"><sup>10</sup> Faculty of Science, Liverpool John Moores University, Liverpool, UK</div><div class="affiliation"><sup>11</sup> Norfolk and Norwich University NHS Trust, Norwich, UK</div><div class="affiliation"><sup>12</sup> Department of Rheumatology, Cambridge University Hospitals, Cambridge, UK,</div><div class="affiliation"><sup>13</sup> University Hospital of Leicester NHS Trust, Leicester General Hospital, Leicester, UK</div><div class="affiliation"><sup>14</sup> Statistical Science, University College London, London, UK</div><div class="affiliation"><sup>*</sup> Corresponding author<span class="before-email-separator">; </span><span class="email-label">Email: </span><a href="mailto:dev@null" data-email="ku.ca.vil@lebeog.saerdna/moc.liamtekcor@lebeogsaerdna" class="oemail">ku.ca.vil@lebeog.saerdna/moc.liamtekcor@lebeogsaerdna</a></div></div><div class="half_rhythm">Southampton (UK): <a href="http://www.journalslibrary.nihr.ac.uk/eme" ref="pagearea=meta&targetsite=external&targetcat=link&targettype=publisher"><span itemprop="publisher">NIHR Journals Library</span></a>; <span itemprop="datePublished">2017 Nov</span>.</div><div class="half_rhythm"><ul class="inline_list"><li><span class="label"><a data-jig="ncbidialog" href="#_ncbi_dlg_cpyrght_NBK464478" data-jigconfig="modal:true">Copyright and
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Permissions</a></span></li></ul></div><div id="_ncbi_dlg_cpyrght_NBK464478" style="display:none" title="Copyright and Permissions"><div><div>Copyright © Queen’s Printer and Controller of HMSO 2017. This work was produced by Goebel et al. under the terms of a commissioning contract issued by the Secretary of State for Health. This issue may be freely reproduced for the purposes of private research and study and extracts (or indeed, the full report) may be included in professional journals provided that suitable acknowledgement is made and the reproduction is not associated with any form of advertising. Applications for commercial reproduction should be addressed to: NIHR Journals Library, National Institute for Health Research, Evaluation, Trials and Studies Coordinating Centre, Alpha House, University of Southampton Science Park, Southampton SO16 7NS, UK.</div><div class="half_rhythm"></div></div></div><div class="bk_noprnt"><form method="get" action="/books/n/ukeme0405/" id="bk_srch"><div class="bk_search"><label for="bk_term" class="offscreen_noflow">Search term</label><input type="text" title="Search this book" id="bk_term" name="term" value="" data-jig="ncbiclearbutton" /> <input type="submit" class="jig-ncbibutton" value="Search this book" submit="false" style="padding: 0.1em 0.4em;" /></div></form></div></div></div></div><div class="body-content whole_rhythm" itemprop="text"><div itemprop="description"><h2>Headline</h2><p>Low-dose intravenous immunoglobulin was not effective in relieving pain in longstanding complex regional pain syndrome.</p></div><div itemprop="description"><h2>Abstract</h2><div id="abs1-1"><h4 class="inline">Background:</h4><p>Complex regional pain syndrome (CRPS) is a rare, severe post-traumatic pain condition affecting distal limbs. Patients who do not spontaneously improve in 12 months are classed as having ‘long-standing CRPS’ and often cannot be effectively treated, leading to a poor prognosis. CRPS is associated with functional autoantibodies. Two small trials, including a randomised controlled trial, have suggested that low-dose intravenous immunoglobulin (IVIg) may be an effective treatment for some patients.</p></div><div id="abs1-2"><h4 class="inline">Objective:</h4><p>We hypothesised that low-dose IVIg is effective for reducing pain in long-standing CRPS.</p></div><div id="abs1-3"><h4 class="inline">Methods:</h4><p>A randomised, double blinded placebo-controlled multicentre trial in seven UK pain management centres. Patients were eligible if they had moderate or severe long-standing CRPS that they had experienced for up to 5 years. Participants were randomly allocated to receive 0.5 g/kg IVIg, the active intervention, or visually indistinguishable 0.1% albumin in saline placebo. Randomisation was initiated by study sites via an independent online randomisation system and was 1 : 1 with varying block sizes, stratified by study centre. Participants, investigators and assessors were blinded to group assignment. The study drug/placebo was infused intravenously at the study centres on day 1 and day 23 after randomisation. The primary outcome was the 24-hour average pain intensity between day 6 and day 42, on an 11-point (0–10) numeric rating scale, compared between the groups. Outcomes were analysed using a mixed-effects regression model that used 37 measurements of pain intensity (the primary outcome) per participant. All patients who received an infusion and provided any outcome were included in the intention-to-treat analysis.</p></div><div id="abs1-4"><h4 class="inline">Results:</h4><p>A total of 111 patients were recruited and assigned between 27 August 2013 and 28 October 2015. Three patients were excluded because they had been inappropriately randomised, five patients were withdrawn from the primary analysis because they provided no outcomes and 103 patients were analysed for the primary outcome. The average pain score in the IVIg group was 0.27 units (95% confidence interval –0.24 to 0.80 units) higher than in the placebo group. Therefore, there is no significant evidence of a treatment effect at the 5% level and there was no significant difference between groups. Six serious adverse events but no suspected unexpected serious adverse reactions were reported during the blinded and open-label phase.</p></div><div id="abs1-6"><h4 class="inline">Conclusion and future work:</h4><p>Low-dose immunoglobulin was not effective in relieving pain in patients with moderate to severe CRPS of 1–5 years’ duration. Better drug treatments for long-standing CRPS are urgently required.</p></div><div id="abs1-7"><h4 class="inline">Trial registration:</h4><p>Current Controlled Trials ISRCTN42179756.</p></div><div id="abs1-8"><h4 class="inline">Funding:</h4><p>This project was funded by the Efficacy and Mechanism Evaluation programme, a Medical Research Council and National Institute for Health Research partnership. Additional funding was obtained by the Pain Relief Foundation. Biotest UK Ltd provided the active study medication at no cost.</p></div></div><div><h2>Contents</h2><div class="bktoc_all_cntnr top align_right" style="display:none"><ul class="inline_list_right"><li><a class="bktoc_all_exp" href="#">Expand All</a></li><li style="margin-left:.8em"><a class="bktoc_all_clps" href="#">Collapse All</a></li></ul></div><ul id="toc_tllNBK464478_toc_abs2" class="simple-list toc toc-toggle"><li class="half_rhythm" id="toc_itm_NBK464478_toc_abs2"><a class="toc-item" href="/books/n/ukeme0405/abs2/">Plain English summary</a></li><li class="half_rhythm" id="toc_itm_NBK464478_toc_abs3"><a class="toc-item" href="/books/n/ukeme0405/abs3/">Scientific summary</a></li><li class="half_rhythm" id="toc_itm_NBK464478_toc_s1"><a class="toc-item" href="/books/n/ukeme0405/s1/">Chapter 1. Introduction</a><ul id="toc_lst_NBK464478_toc_s1" class="simple-list toc bktoc_lst_exp"><li class="half_rhythm" id="toc_itm_NBK464478_toc_s1-1"><a class="toc-item" href="/books/n/ukeme0405/s1/#s1-1">Background</a></li></ul></li><li class="half_rhythm" id="toc_itm_NBK464478_toc_s2"><a class="toc-item" href="/books/n/ukeme0405/s2/">Chapter 2. Objectives</a><ul id="toc_lst_NBK464478_toc_s2" class="simple-list toc bktoc_lst_exp"><li class="half_rhythm" id="toc_itm_NBK464478_toc_s2-1"><a class="toc-item" href="/books/n/ukeme0405/s2/#s2-1">Primary objective</a></li><li class="half_rhythm" id="toc_itm_NBK464478_toc_s2-2"><a class="toc-item" href="/books/n/ukeme0405/s2/#s2-2">Secondary objectives</a></li></ul></li><li class="half_rhythm" id="toc_itm_NBK464478_toc_s3"><a class="toc-item" href="/books/n/ukeme0405/s3/">Chapter 3. Methods</a><ul id="toc_lst_NBK464478_toc_s3" class="simple-list toc bktoc_lst_exp"><li class="half_rhythm" id="toc_itm_NBK464478_toc_s3-1"><a class="toc-item" href="/books/n/ukeme0405/s3/#s3-1">Study design and participants</a></li><li class="half_rhythm" id="toc_itm_NBK464478_toc_s3-2"><a class="toc-item" href="/books/n/ukeme0405/s3/#s3-2">Eligibility criteria</a></li><li class="half_rhythm" id="toc_itm_NBK464478_toc_s3-3"><a class="toc-item" href="/books/n/ukeme0405/s3/#s3-3">Participating centres and recruitment dates</a></li><li class="half_rhythm" id="toc_itm_NBK464478_toc_s3-4"><a class="toc-item" href="/books/n/ukeme0405/s3/#s3-4">Interventions</a></li><li class="half_rhythm" id="toc_itm_NBK464478_toc_s3-5"><a class="toc-item" href="/books/n/ukeme0405/s3/#s3-5">Outcomes</a></li><li class="half_rhythm" id="toc_itm_NBK464478_toc_s3-6"><a class="toc-item" href="/books/n/ukeme0405/s3/#s3-6">Randomisation and blinding</a></li><li class="half_rhythm" id="toc_itm_NBK464478_toc_s3-7"><a class="toc-item" href="/books/n/ukeme0405/s3/#s3-7">Statistical analysis</a></li><li class="half_rhythm" id="toc_itm_NBK464478_toc_s3-8"><a class="toc-item" href="/books/n/ukeme0405/s3/#s3-8">Patient and public involvement</a></li><li class="half_rhythm" id="toc_itm_NBK464478_toc_s3-9"><a class="toc-item" href="/books/n/ukeme0405/s3/#s3-9">Ethics</a></li><li class="half_rhythm" id="toc_itm_NBK464478_toc_s3-10"><a class="toc-item" href="/books/n/ukeme0405/s3/#s3-10">Protocol changes</a></li></ul></li><li class="half_rhythm" id="toc_itm_NBK464478_toc_s4"><a class="toc-item" href="/books/n/ukeme0405/s4/">Chapter 4. Results</a><ul id="toc_lst_NBK464478_toc_s4" class="simple-list toc bktoc_lst_exp"><li class="half_rhythm" id="toc_itm_NBK464478_toc_s4-1"><a class="toc-item" href="/books/n/ukeme0405/s4/#s4-1">Withdrawals from study medication</a></li><li class="half_rhythm" id="toc_itm_NBK464478_toc_s4-2"><a class="toc-item" href="/books/n/ukeme0405/s4/#s4-2">Baseline characteristics</a></li><li class="half_rhythm" id="toc_itm_NBK464478_toc_s4-3"><a class="toc-item" href="/books/n/ukeme0405/s4/#s4-3">Time to infusion</a></li><li class="half_rhythm" id="toc_itm_NBK464478_toc_s4-4"><a class="toc-item" href="/books/n/ukeme0405/s4/#s4-4">Participant follow-up (blinded phase: days 6–42)</a></li><li class="half_rhythm" id="toc_itm_NBK464478_toc_s4-5"><a class="toc-item" href="/books/n/ukeme0405/s4/#s4-5">Primary analysis (<i>n</i> = 103)</a></li><li class="half_rhythm" id="toc_itm_NBK464478_toc_s4-6"><a class="toc-item" href="/books/n/ukeme0405/s4/#s4-6">Absolute pain reduction</a></li><li class="half_rhythm" id="toc_itm_NBK464478_toc_s4-7"><a class="toc-item" href="/books/n/ukeme0405/s4/#s4-7">Percentage pain reduction</a></li><li class="half_rhythm" id="toc_itm_NBK464478_toc_s4-8"><a class="toc-item" href="/books/n/ukeme0405/s4/#s4-8">Sensitivity analyses</a></li><li class="half_rhythm" id="toc_itm_NBK464478_toc_s4-9"><a class="toc-item" href="/books/n/ukeme0405/s4/#s4-9">Exploratory analyses</a></li><li class="half_rhythm" id="toc_itm_NBK464478_toc_s4-10"><a class="toc-item" href="/books/n/ukeme0405/s4/#s4-10">Open-label results</a></li><li class="half_rhythm" id="toc_itm_NBK464478_toc_s4-11"><a class="toc-item" href="/books/n/ukeme0405/s4/#s4-11">Secondary outcomes</a></li></ul></li><li class="half_rhythm" id="toc_itm_NBK464478_toc_s5"><a class="toc-item" href="/books/n/ukeme0405/s5/">Chapter 5. Discussion</a></li><li class="half_rhythm" id="toc_itm_NBK464478_toc_s6"><a class="toc-item" href="/books/n/ukeme0405/s6/">Chapter 6. Conclusion</a></li><li class="half_rhythm" id="toc_itm_NBK464478_toc_ack1"><a class="toc-item" href="/books/n/ukeme0405/ack1/">Acknowledgements</a></li><li class="half_rhythm" id="toc_itm_NBK464478_toc_ref1"><a class="toc-item" href="/books/n/ukeme0405/ref1/">References</a></li><li class="half_rhythm" id="toc_itm_NBK464478_toc_app1"><a class="toc-item" href="/books/n/ukeme0405/app1/">Appendix 1. Patient information sheet</a></li><li class="half_rhythm" id="toc_itm_NBK464478_toc_app2"><a class="toc-item" href="/books/n/ukeme0405/app2/">Appendix 2. Consent form</a></li><li class="half_rhythm" id="toc_itm_NBK464478_toc_app3"><a class="toc-item" href="/books/n/ukeme0405/app3/">Appendix 3. Research diagnostic criteria (the ‘Budapest Criteria’) for complex regional pain syndrome</a></li><li class="half_rhythm" id="toc_itm_NBK464478_toc_app4"><a class="toc-item" href="/books/n/ukeme0405/app4/">Appendix 4. Weight-determined dosing guide</a></li><li class="half_rhythm" id="toc_itm_NBK464478_toc_app5"><a class="toc-item" href="/books/n/ukeme0405/app5/">Appendix 5. Patient-recommended scale</a></li><li class="half_rhythm" id="toc_itm_NBK464478_toc_g1"><a class="toc-item" href="/books/n/ukeme0405/g1/">List of abbreviations</a></li></ul><div class="bktoc_all_cntnr align_right" style="display:none"><ul class="inline_list_right"><li><a class="bktoc_all_exp" href="#">Expand All</a></li><li style="margin-left:.8em"><a class="bktoc_all_clps" href="#">Collapse All</a></li></ul></div></div><div class="pmc_boxed-text-box fm-sec whole_rhythm"><h3>About the Series</h3><div class="half_rhythm"><div>Efficacy and Mechanism Evaluation</div></div><div class="half_rhythm"><div>ISSN (Print): 2050-4365</div><div>ISSN (Electronic): 2050-4373</div></div></div><div><div id="n1-1"><h2>Article history</h2><p>The research reported in this issue of the journal was funded by the EME programme as project number 11/14/33. The contractual start date was in December 2012. The final report began editorial review in August 2016 and was accepted for publication in April 2017. The authors have been wholly responsible for all data collection, analysis and interpretation, and for writing up their work. The EME editors and production house have tried to ensure the accuracy of the authors’ report and would like to thank the reviewers for their constructive comments on the final report document. However, they do not accept liability for damages or losses arising from material published in this report.</p></div><div id="n1-2"><h2>Declared competing interests of authors</h2><p>Andreas Goebel reports grants from the National Institute for Health Research (NIHR) Medical Research Council (MRC) Efficacy and Mechanism Evaluation (EME) programme, other funds from Biotest AG, Germany, and grants from Biotest AG during the conduct of the study. Furthermore, he received personal fees from Biotest AG and Axsome Therapeutics outside the submitted work. Mick Serpell reports grants from NIHR EME programme (a MRC and NIHR partnership), grants for additional funding obtained by the Pain Relief Foundation Liverpool, and non-financial support was received from Biotest UK Ltd, which provided the active study medication at no cost during the study. He has also received research support, consulting fees or honoraria in the past 3 years from Astellas Pharma, Grünenthal Ltd, NAPP and Pfizer. Nick Shenker reports NIHR funding for researchers' time during the conduct of the study.</p></div></div><p class="small">Last reviewed: August 2016; Accepted: April 2017.</p></div></div>
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<div class="post-content"><div><div class="half_rhythm"><a href="/books/about/copyright/">Copyright</a> © Queen’s Printer and Controller of HMSO 2017. This work was produced by Goebel <i>et al.</i> under the terms of a commissioning contract issued by the Secretary of State for Health. This issue may be freely reproduced for the purposes of private research and study and extracts (or indeed, the full report) may be included in professional journals provided that suitable acknowledgement is made and the reproduction is not associated with any form of advertising. Applications for commercial reproduction should be addressed to: NIHR Journals Library, National Institute for Health Research, Evaluation, Trials and Studies Coordinating Centre, Alpha House, University of Southampton Science Park, Southampton SO16 7NS, UK.</div><div class="small"><span class="label">Bookshelf ID: NBK464478</span><span class="label">PMID: <a href="https://pubmed.ncbi.nlm.nih.gov/29144634" title="PubMed record of this title" ref="pagearea=meta&targetsite=entrez&targetcat=link&targettype=pubmed">29144634</a></span>DOI: <a href="http://dx.crossref.org/10.3310/eme04050" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">10.3310/eme04050</a></div><div style="margin-top:2em" class="bk_noprnt"><div class="pagination bk_noprnt"><span class="inactive page_link prev">< Prev</span><a class="active page_link next" href="/books/n/ukeme0405/abs2/" title="Next page in this title">Next ></a></div></div></div></div>
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<div xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"></div><div class="portlet"><div class="portlet_head"><div class="portlet_title"><h3><span>Views</span></h3></div><a name="Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="PDF_download" id="Shutter"></a></div><div class="portlet_content"><ul xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="simple-list"><li><a href="/books/NBK464478/?report=reader">PubReader</a></li><li><a href="/books/NBK464478/?report=printable">Print View</a></li><li><a data-jig="ncbidialog" href="#_ncbi_dlg_citbx_NBK464478" data-jigconfig="width:400,modal:true">Cite this Page</a><div id="_ncbi_dlg_citbx_NBK464478" style="display:none" title="Cite this Page"><div class="bk_tt">Goebel A, Bisla J, Carganillo R, et al. A randomised placebo-controlled Phase III multicentre trial: low-dose intravenous immunoglobulin treatment for long-standing complex regional pain syndrome (LIPS trial). Southampton (UK): NIHR Journals Library; 2017 Nov. 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