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<div class="pre-content"><div><div class="bk_prnt"><p class="small">NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.</p><p>National Collaborating Centre for Nursing and Supportive Care (UK). Irritable Bowel Syndrome in Adults: Diagnosis and Management of Irritable Bowel Syndrome in Primary Care [Internet]. London: Royal College of Nursing (UK); 2008 Feb. (NICE Clinical Guidelines, No. 61.)</p></div><div class="bk_msg_box bk_bttm_mrgn clearfix bk_noprnt"><div class="iconblock clearfix"><a class="img_link icnblk_img" title="Table of Contents Page" href="/books/n/nicecg61guid/"><img class="source-thumb" src="/corehtml/pmc/pmcgifs/bookshelf/thumbs/th-nicecg61guid-lrg.png" alt="Cover" height="100px" width="80px" /></a><div class="icnblk_cntnt"><ul class="messages"><li class="info icon"><span class="icon"><a href="/books/n/nicecg61guid/">See 2017 Partial Update</a></span></li></ul></div></div></div><div class="messagearea bk_noprnt" style="margin-bottom:1.3846em "><ul class="messages"><li class="warn icon"><span class="icon">Update information March 2017 Recommendation 1.1.1.2 in the short version was updated by NICE with more recent guidance on recognition and referral for suspected cancer. Recommendation 1.1.1.3 in the short version was removed as it was no longer needed after the changes to recommendation 1.1.1.2. February 2015 NICE has made new recommendations relating to the clinical management (dietary and lifestyle advice, and pharmacological therapy) of people with IBS. The recommendations and evidence in sections 3, 7.6, 8.4, 8.5.2 and 9.1 of this guideline that have been highlighted in grey have been stood down and replaced. New recommendations on dietary and lifestyle advice, and pharmacological therapy, can be found in the irritable bowel syndrome in adults update CG61.1. September 2012 A recommendation in this guideline (see pages 28 and 37) has been partially updated by recommendation 1.1.2.1 in 'Ovarian cancer' (NICE clinical guideline 122, 2011).</span></li></ul></div><div class="bk_prnt"><p style="color:red;"><strong>Update information March 2017 Recommendation 1.1.1.2 in the short version was updated by NICE with more recent guidance on recognition and referral for suspected cancer. Recommendation 1.1.1.3 in the short version was removed as it was no longer needed after the changes to recommendation 1.1.1.2. February 2015 NICE has made new recommendations relating to the clinical management (dietary and lifestyle advice, and pharmacological therapy) of people with IBS. The recommendations and evidence in sections 3, 7.6, 8.4, 8.5.2 and 9.1 of this guideline that have been highlighted in grey have been stood down and replaced. New recommendations on dietary and lifestyle advice, and pharmacological therapy, can be found in the irritable bowel syndrome in adults update CG61.1. September 2012 A recommendation in this guideline (see pages 28 and 37) has been partially updated by recommendation 1.1.2.1 in 'Ovarian cancer' (NICE clinical guideline 122, 2011).</strong></p></div><div class="iconblock clearfix whole_rhythm no_top_margin bk_noprnt"><a class="img_link icnblk_img" title="Table of Contents Page" href="/books/n/nicecg61/"><img class="source-thumb" src="/corehtml/pmc/pmcgifs/bookshelf/thumbs/th-nicecg61-lrg.png" alt="Cover of Irritable Bowel Syndrome in Adults" height="100px" width="80px" /></a><div class="icnblk_cntnt eight_col"><h2>Irritable Bowel Syndrome in Adults: Diagnosis and Management of Irritable Bowel Syndrome in Primary Care [Internet].</h2><a data-jig="ncbitoggler" href="#__NBK51949_dtls__">Show details</a><div style="display:none" class="ui-widget" id="__NBK51949_dtls__"><div>NICE Clinical Guidelines, No. 61.</div><div>National Collaborating Centre for Nursing and Supportive Care (UK).</div><div>London: <a href="http://www.rcn.org.uk/" ref="pagearea=page-banner&targetsite=external&targetcat=link&targettype=publisher">Royal College of Nursing (UK)</a>; 2008 Feb.</div></div><div class="half_rhythm"><ul class="inline_list"><li style="margin-right:1em"><a class="bk_cntns" href="/books/n/nicecg61/">Contents</a></li></ul></div></div><div class="icnblk_cntnt two_col"><div class="pagination bk_noprnt"><a class="active page_link prev" href="/books/n/nicecg61/appendixes.app4/" title="Previous page in this title">< Prev</a><a class="active page_link next" href="/books/n/nicecg61/appendixes.app6/" title="Next page in this title">Next ></a></div></div></div></div></div>
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<div class="main-content lit-style" itemscope="itemscope" itemtype="http://schema.org/CreativeWork"><div class="meta-content fm-sec"><h1 id="_NBK51949_"><span class="label">Appendix E</span><span class="title" itemprop="name">Excluded studies</span></h1></div><div class="body-content whole_rhythm" itemprop="text"><p id="appendixes.app5.tu1"><a href="/books/NBK51949/table/appendixes.app5.tu1/?report=objectonly" target="object">E1. DIAGNOSIS</a></p><p id="appendixes.app5.tu2"><a href="/books/NBK51949/table/appendixes.app5.tu2/?report=objectonly" target="object">E2. PHYSICAL ACTIVITY</a></p><p id="appendixes.app5.tu3"><a href="/books/NBK51949/table/appendixes.app5.tu3/?report=objectonly" target="object">E3. FIBRE</a></p><p id="appendixes.app5.tu4"><a href="/books/NBK51949/table/appendixes.app5.tu4/?report=objectonly" target="object">E4. PRE/PRO-BIOTICS</a></p><p id="appendixes.app5.tu5"><a href="/books/NBK51949/table/appendixes.app5.tu5/?report=objectonly" target="object">E5. ALOE VERA</a></p><p id="appendixes.app5.tu6"><a href="/books/NBK51949/table/appendixes.app5.tu6/?report=objectonly" target="object">E6. EXCLUSION DIET</a></p><p id="appendixes.app5.tu7"><a href="/books/NBK51949/table/appendixes.app5.tu7/?report=objectonly" target="object">E7. LAXATIVES</a></p><p id="appendixes.app5.tu8"><a href="/books/NBK51949/table/appendixes.app5.tu8/?report=objectonly" target="object">E8. ANTI-MOTILITY AGENTS</a></p><p id="appendixes.app5.tu9"><a href="/books/NBK51949/table/appendixes.app5.tu9/?report=objectonly" target="object">E9. ANTISPASMODICS</a></p><p id="appendixes.app5.tu10"><a href="/books/NBK51949/table/appendixes.app5.tu10/?report=objectonly" target="object">E10. ANTIDEPRESSANTS</a></p><p id="appendixes.app5.tu11"><a href="/books/NBK51949/table/appendixes.app5.tu11/?report=objectonly" target="object">E11. ADVERSE EFFECTS</a></p><p id="appendixes.app5.tu11a"><a href="/books/NBK51949/table/appendixes.app5.tu11a/?report=objectonly" target="object">E12. RELAXATION</a></p><p id="appendixes.app5.tu12"><a href="/books/NBK51949/table/appendixes.app5.tu12/?report=objectonly" target="object">E13. BIOFEEDBACK</a></p><p id="appendixes.app5.tu13"><a href="/books/NBK51949/table/appendixes.app5.tu13/?report=objectonly" target="object">E14. PSYCHOTHERAPY</a></p><p id="appendixes.app5.tu14"><a href="/books/NBK51949/table/appendixes.app5.tu14/?report=objectonly" target="object">E15. COGNITIVE BEHAVIOUR THERAPY</a></p><p id="appendixes.app5.tu15"><a href="/books/NBK51949/table/appendixes.app5.tu15/?report=objectonly" target="object">E16. HYPNOTHERAPY</a></p><p id="appendixes.app5.tu15a"><a href="/books/NBK51949/table/appendixes.app5.tu15a/?report=objectonly" target="object">E17. REFLEXOLOGY</a></p><p id="appendixes.app5.tu16"><a href="/books/NBK51949/table/appendixes.app5.tu16/?report=objectonly" target="object">E18. ACUPUNCTURE</a></p><p id="appendixes.app5.tu16a"><a href="/books/NBK51949/table/appendixes.app5.tu16a/?report=objectonly" target="object">E19. HERBAL MEDICINE</a></p><p id="appendixes.app5.tu17"><a href="/books/NBK51949/table/appendixes.app5.tu17/?report=objectonly" target="object">E21. PSYCHOSOCIAL</a></p><p id="appendixes.app5.tu18"><a href="/books/NBK51949/table/appendixes.app5.tu18/?report=objectonly" target="object">E22. PATIENT INFORMATION</a></p><p id="appendixes.app5.tu19"><a href="/books/NBK51949/table/appendixes.app5.tu19/?report=objectonly" target="object">E23. COST-EFFECTIVENESS OF STRATEGIES TO MANAGE IBS: TESTING FOR ALTERNATIVE DIAGNOSES</a></p><p id="appendixes.app5.tu20"><a href="/books/NBK51949/table/appendixes.app5.tu20/?report=objectonly" target="object">E24. COST-EFFECTIVENESS OF STRATEGIES TO MANAGE IBS: INTERVENTION TO MANAGE IBS</a></p><div id="appendixes.app5.rl1"><h2 id="_appendixes_app5_rl1_">REFERENCE LIST OF EXCLUDED STUDIES</h2><ol><li><div class="bk_ref" id="appendixes.app5.r1">Irritable bowel syndrome: the cost-effective diagnosis. <span><span class="ref-journal">Emergency Medicine. </span>1994;<span class="ref-vol">26</span>(9):31.</span> [No authors listed]</div></li><li><div class="bk_ref" id="appendixes.app5.r2">Inflammatory bowel disease: ulcerative colitis. <span><span class="ref-journal">American Journal of Managed Care. </span>1997;<span class="ref-vol">3</span>(Suppl(29 ref))</span> [No authors listed]</div></li><li><div class="bk_ref" id="appendixes.app5.r3">Early ovarian cancer remains elusive. <span><span class="ref-journal">Medicine Today. </span>2004;<span class="ref-vol">5</span>(9):7–8.</span> [No authors listed]</div></li><li><div class="bk_ref" id="appendixes.app5.r4">A General Practice Research Group. Multicentre general practice comparison of loperamide and diphenoxylate with atropine in the treatment of acute diarrhoea in adults. <span><span class="ref-journal">British Journal of Clinical Practice. </span>1979;<span class="ref-vol">33</span>(3):77–9.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/444389" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 444389</span></a>]</div></li><li><div class="bk_ref" id="appendixes.app5.r5">Aberg A, Holmberg G. Controlled trial of a new antidepressive, amoxapine, in comparison with amitriptyline. <span><span class="ref-journal">Current Therapeutic Research, Clinical and Experimental. </span>1977;<span class="ref-vol">22</span>(2):304–15.</span></div></li><li><div class="bk_ref" id="appendixes.app5.r6">Addolorato G, Marsigli L, Capristo E, Caputo F, Dall’Aglio C, Baudanza P. Anxiety and depression: a common feature of health care seeking patients with irritable bowel syndrome and food allergy. <span><span class="ref-journal">Hepato-Gastroenterology. </span>1998;<span class="ref-vol">45</span>(23):1559–64.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/9840105" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 9840105</span></a>]</div></li><li><div class="bk_ref" id="appendixes.app5.r7">Adler SN, Jacob H, Lijovetzky G, Mulder CJJ, Zwiers A. Positive coeliac serology in irritable bowel syndrome patients with normal duodenal biopsies: Video capsule endoscopy findings and HLA-DQ typing may affect clinical management. <span><span class="ref-journal">Journal of Gastrointestinal and Liver Diseases. </span>2006;<span class="ref-vol">15</span>(3):221–5.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/17013445" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 17013445</span></a>]</div></li><li><div class="bk_ref" id="appendixes.app5.r8">Agency for Healthcare Research, Quality. Mind-body interventions for gastrointestinal conditions. <span><span class="ref-journal">AHRQ Evidence Reports. </span>2001:40.</span></div></li><li><div class="bk_ref" id="appendixes.app5.r9">Agreus L, Talley NJ, Svardsudd K, Tibblin G, Jones MP. Identifying dyspepsia and irritable bowel syndrome: the value of pain or discomfort, and bowel habit descriptors. <span><span class="ref-journal">Scandinavian Journal of Gastroenterology. </span>2000;<span class="ref-vol">35</span>(2):142–51.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/10720111" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 10720111</span></a>]</div></li><li><div class="bk_ref" id="appendixes.app5.r10">Alderman J. Managing irritable bowel syndrome. <span><span class="ref-journal">Advance for Nurse Practitioners. </span>1999;<span class="ref-vol">7</span>(1):40–78.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/10030169" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 10030169</span></a>]</div></li><li><div class="bk_ref" id="appendixes.app5.r11">Alestig K, Trollfors B, Stenqvist K. Acute non-specific diarrhoea: studies on the use of charcoal, kaolin-pectin and diphenoxylate. <span><span class="ref-journal">Practitioner. </span>1979;<span class="ref-vol">222</span>(1332):859–62.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/482236" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 482236</span></a>]</div></li><li><div class="bk_ref" id="appendixes.app5.r12">Alevizos B, Christodoulou GN, Ioannidis C, Voulgari A, Mantidis A, Spiliadis C. The efficacy of amineptine in the treatment of depressive patients with irritable bowel syndrome. <span><span class="ref-journal">Clinical Neuropharmacology. </span>1989;<span class="ref-vol">12</span>(Suppl 2):S66–S76.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/2698273" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 2698273</span></a>]</div></li><li><div class="bk_ref" id="appendixes.app5.r13">Allison MC, Sercombe J, Pounder RE. A double-blind crossover comparison of lidamidine, loperamide and placebo for the control of chronic diarrhoea. <span><span class="ref-journal">Alimentary Pharmacology and Therapeutics. </span>1988;<span class="ref-vol">2</span>(4):347–51.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/2979258" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 2979258</span></a>]</div></li><li><div class="bk_ref" id="appendixes.app5.r14">Ansseau M, Von Frenckell R, Mertens C, De Wilde J, Botte L, Devoitille J-M, Evrard J-L, De Nayer A, Darimont P, Dejaiffe G, Mirel J, Meurice E, Parent M, Couzinier J-P, Demarez J-P, Serre C. Controlled comparison of two doses of milnacipran (F 2207) and amitriptyline in major depressive inpatients. <span><span class="ref-journal">Psychopharmacology. </span>1989;<span class="ref-vol">98</span>(2):163–8.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/2569214" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 2569214</span></a>]</div></li><li><div class="bk_ref" id="appendixes.app5.r15">Ao X, Wang N. Auricular-plaster therapy for treatment of IBS. <span><span class="ref-journal">Journal of Traditional Chinese Medicine. </span>2004;<span class="ref-vol">24</span>(3):166–7.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/15510788" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 15510788</span></a>]</div></li><li><div class="bk_ref" id="appendixes.app5.r16">Arffmann S, Andersen JR, Hegnhöj J, Schaffalitzky de Muckadell OB, Mogensen NB, Krag E. Irritable bowel syndrome treated with wheat brain - a controlled double blind trial. <span><span class="ref-journal">Scandinavian Journal of Gastroenterology - Supplement. </span>1983;<span class="ref-vol">86</span>:3.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/2988107" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 2988107</span></a>]</div></li><li><div class="bk_ref" id="appendixes.app5.r17">Armbrecht U, Reul W, Stockbrugger RW. The influence of telenzepine on gastrointestinal transit: comparison with placebo and domperidone. <span><span class="ref-journal">Zeitschrift Fur Gastroenterologie. </span>1990;<span class="ref-vol">28</span>(2):85–9.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/2181787" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 2181787</span></a>]</div></li><li><div class="bk_ref" id="appendixes.app5.r18">Arn I, Theorell T, Uvnas-Moberg K, Jonsson C-O. Psychodrama group therapy for patients with functional gastrointestinal disorders - A controlled long-term follow-up study. <span><span class="ref-journal">Psychotherapy and Psychosomatics. </span>1989;<span class="ref-vol">51</span>(3):113–9.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/2636416" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 2636416</span></a>]</div></li><li><div class="bk_ref" id="appendixes.app5.r19">Atkinson K, Tokmakajian S, Watson W, Gregor J. Evaluation of the endomysial antibody for celiac disease: operating properties and associated cost implications for clinical practice. <span><span class="ref-journal">Canadian Journal of Gastroenterology. </span>1995;<span class="ref-vol">11</span>(8):673–7.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/9459047" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 9459047</span></a>]</div></li><li><div class="bk_ref" id="appendixes.app5.r20">Avigan M, Justice R, Mackey AC, Nair N. Re: Brandt et al.--An evidence-based approach to the management of irritable bowel syndrome in North America. <span><span class="ref-journal">American Journal of Gastroenterology. </span>2003;<span class="ref-vol">98</span>(9):2105–6.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/14499800" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 14499800</span></a>]</div></li><li><div class="bk_ref" id="appendixes.app5.r21">Awad R, Dibildox M, Ortiz F. Irritable bowel syndrome treatment using pinaverium bromide as a calcium channel blocker. A randomized double-blind placebo-controlled trial. <span><span class="ref-journal">Acta Gastroenterologica Latinoamericana. </span>1995;<span class="ref-vol">25</span>(3):137–44.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/8600700" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 8600700</span></a>]</div></li><li><div class="bk_ref" id="appendixes.app5.r22">Awad RA, Cordova VH, Dibildox M, Santiago R, Camacho S. Reduction of post-prandial motility by pinaverium bromide a calcium channel blocker acting selectively on the gastrointestinal tract in patients with irritable bowel syndrome. <span><span class="ref-journal">Acta Gastroenterologica Latinoamericana. </span>1997;<span class="ref-vol">27</span>(4):247–51.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/9401097" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 9401097</span></a>]</div></li><li><div class="bk_ref" id="appendixes.app5.r23">Baar K. New uses for Aloe vera. <span><span class="ref-journal">Natural Health. </span>1995;<span class="ref-vol">25</span>(6):58–62.</span></div></li><li><div class="bk_ref" id="appendixes.app5.r24">Badiali D, Corazziari E, Habib FI, Tomei E, Bausano G, Magrini P, Anzini F, Torsoli A. Effect of wheat bran in treatment of chronic nonorganic constipation. A double-blind controlled trial. <span><span class="ref-journal">Digestive Diseases and Sciences. </span>1995;<span class="ref-vol">40</span>(2):349–56.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/7851201" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 7851201</span></a>]</div></li><li><div class="bk_ref" id="appendixes.app5.r25">Baeyens R, van dV, De Schepper A, Wollaert F, Reyntjens A. Effects of intravenous and oral domperidone on the motor function of the stomach and small intestine. <span><span class="ref-journal">Postgraduate Medical Journal. </span>1979;<span class="ref-vol">55</span>(Suppl 1):19–23.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/382148" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 382148</span></a>]</div></li><li><div class="bk_ref" id="appendixes.app5.r26">Baldi F, Corinaldesi R, Ferrarini F. Clinical and functional evaluation of octilonium bromide in the treatment of irritable bowel syndrome. A double-blind controlled trial. <span><span class="ref-journal">Clinical Trials Journal. </span>1983;<span class="ref-vol">20</span>(2):77–88.</span></div></li><li><div class="bk_ref" id="appendixes.app5.r27">Baldi F, Longanesi A, Blasi A, Monello S, Cestari R, Missale G, Corazziari E, Badiali G, Pescatori M, Anastasio G. Clinical and functional evaluation of the efficacy of otilonium bromide: a multicenter study in Italy. <span><span class="ref-journal">Italian Journal of Gastroenterology. </span>1991;<span class="ref-vol">23</span>(8 Suppl 1):60–3.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/1756285" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 1756285</span></a>]</div></li><li><div class="bk_ref" id="appendixes.app5.r28">Baldi F, Longanesi A, Blasi A, Monello S, Cestari R, Missale G, Corazziari E, Badiali G, Marzio L, Di Felice F. Octylonium bromide in the treatment of the irritable bowel syndrome: a clinical-functional study. <span><span class="ref-journal">Hepato-Gastroenterology. </span>1992;<span class="ref-vol">39</span>(5):392–5.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/1459516" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 1459516</span></a>]</div></li><li><div class="bk_ref" id="appendixes.app5.r29">Banerjee R, Choung OW, Gupta R, Tandan M, Lakhtakia S, Rao GV, Reddy DN. Rome I criteria are more sensitive than Rome II for diagnosis of irritable bowel syndrome in Indian patients. <span><span class="ref-journal">Indian Journal of Gastroenterology. </span>2005;<span class="ref-vol">24</span>(4):164–6.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/16204906" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 16204906</span></a>]</div></li><li><div class="bk_ref" id="appendixes.app5.r30">Barbara L, Miglioli M. Treatment of irritable bowel syndrome. A double-blind trial of the anticholinergic octatropine methylbromide (Valpin) alone or with the tranquillizer diazepam (Valpinax). <span><span class="ref-journal">Clinical Trials Journal. </span>1979;<span class="ref-vol">16</span>(5):140–6.</span></div></li><li><div class="bk_ref" id="appendixes.app5.r31">Barbezat GO, Clain JE, Halter F. A double-blind trial of loperamide in the treatment of chronic diarrhoea. <span><span class="ref-journal">South African Medical Journal, Suid-Afrikaanse Tydskrif Vir Geneeskunde. </span>1979;<span class="ref-vol">55</span>(13):502–3.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/377521" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 377521</span></a>]</div></li><li><div class="bk_ref" id="appendixes.app5.r32">Barbier P. Double blind controlled trial of a new colonic antispasmodic agent, actylonium bromide. <span><span class="ref-journal">Ars Medici Revue Internationale De Therapie Pratique. </span>1981;<span class="ref-vol">36</span>(21):1879–80.</span></div></li><li><div class="bk_ref" id="appendixes.app5.r33">Bardella MT, Trovato C, Cesana BM, Pagliari C, Gebbia C, Peracchi M. Serological markers for coeliac disease: Is it time to change? <span><span class="ref-journal">Digestive and Liver Disease. </span>2001;<span class="ref-vol">33</span>(5):426–31.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/11529655" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 11529655</span></a>]</div></li><li><div class="bk_ref" id="appendixes.app5.r34">Barrow L, Steed KP, Spiller RC, Maskell NA, Brown JK, Watts PJ, Melia CD, Davies MC, Wilson CG. Quantitative, noninvasive assessment of antidiarrheal actions of codeine using an experimental model of diarrhea in man. <span><span class="ref-journal">Digestive Diseases and Sciences. </span>1993;<span class="ref-vol">38</span>(6):996–1003.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/8389688" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 8389688</span></a>]</div></li><li><div class="bk_ref" id="appendixes.app5.r35">Basilisco G, Camboni G, Bozzani A, Paravicini M, Bianchi PA. Oral naloxone antagonizes loperamide-induced delay of orocecal transit. <span><span class="ref-journal">Digestive Diseases and Sciences. </span>1987;<span class="ref-vol">32</span>(8):829–32.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/3608730" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 3608730</span></a>]</div></li><li><div class="bk_ref" id="appendixes.app5.r36">Bass P, Dennis S. The laxative effects of lactulose in normal and constipated subjects. <span><span class="ref-journal">Journal of Clinical Gastroenterology. </span>1981;<span class="ref-vol">3</span>(Suppl 1):23–8.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/7035543" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 7035543</span></a>]</div></li><li><div class="bk_ref" id="appendixes.app5.r37">Bass P, Clark C, DoPico GA. Comparison of the laxative efficacy and patient preference of calcium polycarbophil tablets and psyllium suspension. <span><span class="ref-journal">Current Therapeutic Research, Clinical and Experimental. </span>1988;<span class="ref-vol">43</span>(4):770–4.</span></div></li><li><div class="bk_ref" id="appendixes.app5.r38">Bassotti G, Gaburri M. Effect of eating and cimetropium bromide (Alginor) on colonic motility. <span><span class="ref-journal">European Journal of Clinical Investigation. </span>1986;<span class="ref-vol">16</span>(Suppl (2 Pt II)):A28.</span></div></li><li><div class="bk_ref" id="appendixes.app5.r39">Bassotti G, Fiorella S, Roselli P, Modesto R. Use of polyethylene glycol solution in slow transit constipation. <span><span class="ref-journal">Italian Journal of Gastroenterology and Hepatology. </span>1999;<span class="ref-vol">31</span>(Suppl 3):S255–S256.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/10726231" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 10726231</span></a>]</div></li><li><div class="bk_ref" id="appendixes.app5.r40">Battaglia G, Morselli-Labate AM, Camarri E, Francavilla A, De Marco F, Mastropaolo G, Naccarato R. 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Seeking clues for a positive diagnosis of the irritable bowel syndrome. <span><span class="ref-journal">European Journal of Clinical Investigation. </span>1987;<span class="ref-vol">17</span>(3):189–93.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/3113963" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 3113963</span></a>]</div></li><li><div class="bk_ref" id="appendixes.app5.r374">Vernia P, Marinaro V, Argnani F, Di Camillo M, Caprilli R. Self-reported milk intolerance in irritable bowel syndrome: what should we believe? <span><span class="ref-journal">Clinical Nutrition. </span>2004;<span class="ref-vol">23</span>(5):996–1000.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/15380888" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 15380888</span></a>]</div></li><li><div class="bk_ref" id="appendixes.app5.r375">Vidakovic-Vukic M. Hypnotherapy in the treatment of irritable bowel syndrome: methods and results in Amsterdam. <span><span class="ref-journal">Scandinavian Journal of Gastroenterology - Supplement. </span>1999;<span class="ref-vol">230</span>:49–51.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/10499462" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 10499462</span></a>]</div></li><li><div class="bk_ref" id="appendixes.app5.r376">Vogler BK, Ernst E. Aloe vera: a systematic review of its clinical effectiveness. <span><span class="ref-journal">British Journal of General Practice. </span>1999;<span class="ref-vol">49</span>(447):823–8.</span> [<a href="/pmc/articles/PMC1313538/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC1313538</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/10885091" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 10885091</span></a>]</div></li><li><div class="bk_ref" id="appendixes.app5.r377">Wahnschaffe U, Ullrich R, Riecken EO, Schulzke JD. Celiac disease-like abnormalities in a subgroup of patients with irritable bowel syndrome. <span><span class="ref-journal">Gastroenterology. </span>2001;<span class="ref-vol">121</span>(6):1329–38.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/11729112" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 11729112</span></a>]</div></li><li><div class="bk_ref" id="appendixes.app5.r378">Walker AF, Middleton RW, Petrowicz O. Artichoke leaf extract reduces symptoms of irritable bowel syndrome in a post-marketing surveillance study. <span><span class="ref-journal">Phytotherapy Research. </span>2001;<span class="ref-vol">15</span>(1):58–61.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/11180525" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 11180525</span></a>]</div></li><li><div class="bk_ref" id="appendixes.app5.r379">Walker EA, Gelfand AN, Gelfand MD, Katon WJ. Psychiatric diagnoses, sexual and physical victimization, and disability in patients with irritable bowel syndrome or inflammatory bowel disease. <span><span class="ref-journal">Psychological Medicine. </span>1995;<span class="ref-vol">25</span>(6):1259–67.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/8637955" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 8637955</span></a>]</div></li><li><div class="bk_ref" id="appendixes.app5.r380">Walter SA, Ragnarsson G, Bodemar G. New criteria for irritable bowel syndrome based on prospective symptom evaluation. <span><span class="ref-journal">American Journal of Gastroenterology. </span>2005;<span class="ref-vol">100</span>(11):2598–9.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/16279922" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 16279922</span></a>]</div></li><li><div class="bk_ref" id="appendixes.app5.r381">Wang H-J, Liang X-M, Yu Z-L, Zhou L-Y, Lin S-R, Geraint M. A randomised, controlled comparison of low-dose polyethylene glycol 3350 plus electrolytes with ispaghula husk in the treatment of adults with chronic functional constipation. <span><span class="ref-journal">Clinical Drug Investigation. </span>2004;<span class="ref-vol">24</span>(10):569–76.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/17523718" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 17523718</span></a>]</div></li><li><div class="bk_ref" id="appendixes.app5.r382">Watson AR, Bowling TE. Irritable bowel syndrome: diagnosis and symptom management. <span><span class="ref-journal">British Journal of Community Nursing. </span>2005;<span class="ref-vol">10</span>(3):118–22.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/15824698" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 15824698</span></a>]</div></li><li><div class="bk_ref" id="appendixes.app5.r383">Whorwell PJ. Hypnotherapy in the irritable bowel syndrome. <span><span class="ref-journal">Stress Medicine. </span>1987;<span class="ref-vol">3</span>(1):5–7.</span></div></li><li><div class="bk_ref" id="appendixes.app5.r384">Whorwell PJ, Prior A, Colgan SM. Hypnotherapy in severe irritable bowel syndrome: further experience. <span><span class="ref-journal">Gut. </span>1987;<span class="ref-vol">28</span>(4):423–5.</span> [<a href="/pmc/articles/PMC1432815/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC1432815</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/3583070" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 3583070</span></a>]</div></li><li><div class="bk_ref" id="appendixes.app5.r385">Wilson S, Roberts L, Roalfe A, Bridge P, Singh S. Prevalence of irritable bowel syndrome: A community survey. <span><span class="ref-journal">British Journal of General Practice. </span>2004;<span class="ref-vol">54</span>(504):495–502.</span> [<a href="/pmc/articles/PMC1324800/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC1324800</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/15239910" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 15239910</span></a>]</div></li><li><div class="bk_ref" id="appendixes.app5.r386">Wise TN. The efficacy of group therapy for patients with irritable bowel syndrome. <span><span class="ref-journal">Psychosomatics. </span>1982;<span class="ref-vol">23</span>(5):465–9.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/7111644" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 7111644</span></a>]</div></li><li><div class="bk_ref" id="appendixes.app5.r387">Wise TN. Group therapy for the irritable bowel syndrome: Themes and process. <span><span class="ref-journal">Journal of Psychiatric Treatment and Evaluation. </span>1982;<span class="ref-vol">4</span>(6):511–5.</span></div></li><li><div class="bk_ref" id="appendixes.app5.r388">Wisten A, Messner T. Fruit and fibre (Pajala porridge) in the prevention of constipation. <span><span class="ref-journal">Scandinavian Journal of Caring Sciences. </span>2005;<span class="ref-vol">19</span>(1):71–6.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/15737169" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 15737169</span></a>]</div></li><li><div class="bk_ref" id="appendixes.app5.r389">Xiao SD, Zhang DZ, Lu H, Jiang SH, Liu HY, Wang GS, Xu GM, Zhang ZB, Lin GJ, Wang GL. Multicenter randomized controlled trial of heat-killed Lactobacillus acidophilus LB in patients with chronic diarrhea. <span><span class="ref-journal">Chinese Journal of Digestive Diseases. </span>2002;<span class="ref-vol">3</span>(4):167–71.</span></div></li><li><div class="bk_ref" id="appendixes.app5.r390">Xiao SD, Zhang dZ, Lu H, Jiang SH, Liu HY, Wang GS, Xu GM, Zhang ZB, Lin GJ, Wang GL. Multicenter, randomized, controlled trial of heat-killed Lactobacillus acidophilus LB in patients with chronic diarrhea. <span><span class="ref-journal">Advances in Therapy. </span>2003;<span class="ref-vol">20</span>(5):253–60.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/14964345" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 14964345</span></a>]</div></li><li><div class="bk_ref" id="appendixes.app5.r391">Yadav SK, Jain AK, Tripathi SN, Gupta JP. Irritable bowel syndrome: therapeutic evaluation of indigenous drugs. <span><span class="ref-journal">Indian Journal of Medical Research. </span>1989;<span class="ref-vol">90</span>:496–503.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/2697693" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 2697693</span></a>]</div></li><li><div class="bk_ref" id="appendixes.app5.r392">Yagil Y, Goldenberg I, Arnon R, Ezra V, Ashkenazi I, Yagil Y, Goldenberg I, Arnon R, Ezra V, Ashkenazi I. Serologic testing for celiac disease in young adults--a cost-effect analysis. <span><span class="ref-journal">Digestive Diseases and Sciences. </span>2005;<span class="ref-vol">50</span>(4):796–805.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/15844721" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 15844721</span></a>]</div></li><li><div class="bk_ref" id="appendixes.app5.r393">Yawn BP, Lydick E, Locke GR, Wollan PC, Bertram SL, Kurland MJ. Do published guidelines for evaluation of irritable bowel syndrome reflect practice? <span><span class="ref-journal">BMC Gastroenterology. </span>2001;<span class="ref-vol">1</span>:11.</span> [<a href="/pmc/articles/PMC59674/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC59674</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/11701092" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 11701092</span></a>]</div></li><li><div class="bk_ref" id="appendixes.app5.r394">Yawn BP, Locke GR III, Lydick E, Wollan PC, Bertram SL, Kurland MJ. Diagnosis and care of irritable bowel syndrome in a community-based population. <span><span class="ref-journal">American Journal of Managed Care. </span>2001;<span class="ref-vol">7</span>(6):585–92.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/11439732" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 11439732</span></a>]</div></li><li><div class="bk_ref" id="appendixes.app5.r395">Zhang HB, Han GH, Zhou XM, Guo XG, Wang BL, Wu KC, Ding J, Fan DM, Shi Y, Zhang SQ. Effects of treatments with otilonium bromide, collodal bismuth tartrate and compound diphenoxylate in the irritable bowel syndrome: A double-blind random controlled study. <span><span class="ref-journal">Chinese Journal of Clinical Pharmacology. </span>2002;<span class="ref-vol">18</span>(5):328–32.</span></div></li><li><div class="bk_ref" id="appendixes.app5.r396">Zhang XJ. Comparative study into the efficacy of loperamide and/or smecta for diarrhea-predominant irritable bowel syndrome. <span><span class="ref-journal">Chinese Journal of Clinical Pharmacology. </span>2000;<span class="ref-vol">16</span>(1):25–6.</span></div></li><li><div class="bk_ref" id="appendixes.app5.r397">Zhou HQ, Li DG, Song GH, Liu QH, Xu XX, Liu HM. Effect of paroxetine hydrochloride and pinaverium bromide therapy in patients with irritable bowel syndrome. <span><span class="ref-journal">Chinese Journal of Clinical Rehabilitation. </span>2002;<span class="ref-vol">6</span>(23):3576–7.</span></div></li><li><div class="bk_ref" id="appendixes.app5.r398">Zhu Z, Li H, Chen L, Wang G, Kan C. Acupuncture treatment of habitual constipation. <span><span class="ref-journal">Journal of Traditional Chinese Medicine. </span>2003;<span class="ref-vol">23</span>(2):133.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/12875080" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 12875080</span></a>]</div></li></ol></div><div id="bk_toc_contnr"></div></div></div>
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<div xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"></div><div class="portlet"><div class="portlet_head"><div class="portlet_title"><h3><span>Views</span></h3></div><a name="Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="PDF_download" id="Shutter"></a></div><div class="portlet_content"><ul xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="simple-list"><li><a href="/books/NBK51949/?report=reader">PubReader</a></li><li><a href="/books/NBK51949/?report=printable">Print View</a></li><li><a data-jig="ncbidialog" href="#_ncbi_dlg_citbx_NBK51949" data-jigconfig="width:400,modal:true">Cite this Page</a><div id="_ncbi_dlg_citbx_NBK51949" style="display:none" title="Cite this Page"><div class="bk_tt">National Collaborating Centre for Nursing and Supportive Care (UK). Irritable Bowel Syndrome in Adults: Diagnosis and Management of Irritable Bowel Syndrome in Primary Care [Internet]. London: Royal College of Nursing (UK); 2008 Feb. (NICE Clinical Guidelines, No. 61.) Appendix E, Excluded studies.<span class="bk_cite_avail"></span></div></div></li><li><a href="/books/n/nicecg61/pdf/">PDF version of this title</a> (6.6M)</li><li><a href="#" class="toggle-glossary-link" title="Enable/disable links to the glossary">Disable Glossary Links</a></li></ul></div></div><div class="portlet"><div class="portlet_head"><div class="portlet_title"><h3><span>Other titles in this collection</span></h3></div><a name="Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="source-links" id="Shutter"></a></div><div class="portlet_content"><ul xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="simple-list"><li><a href="/books/n/nicecollect/">National Institute for Health and Clinical Excellence: Guidance
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