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<meta name="robots" content="INDEX,FOLLOW,NOARCHIVE" /><meta name="citation_inbook_title" content="Mother To Baby | Fact Sheets [Internet]" /><meta name="citation_title" content="Codeine" /><meta name="citation_publisher" content="Organization of Teratology Information Specialists (OTIS)" /><meta name="citation_date" content="2023/04" /><meta name="citation_pmid" content="35951914" /><meta name="citation_fulltext_html_url" content="https://www.ncbi.nlm.nih.gov/books/NBK582651/" /><link rel="schema.DC" href="http://purl.org/DC/elements/1.0/" /><meta name="DC.Title" content="Codeine" /><meta name="DC.Type" content="Text" /><meta name="DC.Publisher" content="Organization of Teratology Information Specialists (OTIS)" /><meta name="DC.Date" content="2023/04" /><meta name="DC.Identifier" content="https://www.ncbi.nlm.nih.gov/books/NBK582651/" /><meta name="description" content="This sheet is about exposure to codeine in pregnancy and while breastfeeding. This information is based on available published literature. It should not take the place of medical care and advice from your healthcare provider." /><meta name="og:title" content="Codeine" /><meta name="og:type" content="book" /><meta name="og:description" content="This sheet is about exposure to codeine in pregnancy and while breastfeeding. This information is based on available published literature. It should not take the place of medical care and advice from your healthcare provider." /><meta name="og:url" content="https://www.ncbi.nlm.nih.gov/books/NBK582651/" /><meta name="og:site_name" content="NCBI Bookshelf" /><meta name="og:image" content="https://www.ncbi.nlm.nih.gov/corehtml/pmc/pmcgifs/bookshelf/thumbs/th-mtb-lrg.png" /><meta name="twitter:card" content="summary" /><meta name="twitter:site" content="@ncbibooks" /><meta name="bk-non-canon-loc" content="/books/n/mtb/codeine-en/" /><link rel="canonical" href="https://www.ncbi.nlm.nih.gov/books/NBK582651/" /><link rel="stylesheet" href="/corehtml/pmc/css/figpopup.css" type="text/css" media="screen" /><link rel="stylesheet" href="/corehtml/pmc/css/bookshelf/2.26/css/books.min.css" type="text/css" /><link rel="stylesheet" href="/corehtml/pmc/css/bookshelf/2.26/css/books_print.min.css" type="text/css" media="print" /><style type="text/css">p a.figpopup{display:inline !important} .bk_tt {font-family: monospace} .first-line-outdent .bk_ref {display: inline} .body-content h2, .body-content .h2 {border-bottom: 1px solid #97B0C8} .body-content h2.inline {border-bottom: none} a.page-toc-label , .jig-ncbismoothscroll a {text-decoration:none;border:0 !important} .temp-labeled-list .graphic {display:inline-block !important} .temp-labeled-list img{width:100%}</style><script type="text/javascript" src="/corehtml/pmc/js/jquery.hoverIntent.min.js"> </script><script type="text/javascript" src="/corehtml/pmc/js/common.min.js?_=3.18"> </script><script type="text/javascript" src="/corehtml/pmc/js/large-obj-scrollbars.min.js"> </script><script type="text/javascript">window.name="mainwindow";</script><script type="text/javascript" src="/corehtml/pmc/js/bookshelf/2.26/book-toc.min.js"> </script><script type="text/javascript" src="/corehtml/pmc/js/bookshelf/2.26/books.min.js"> </script><meta name="book-collection" content="NONE" />
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<div class="pre-content"><div><div class="bk_prnt"><p class="small">NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.</p><p>Mother To Baby | Fact Sheets [Internet]. Brentwood (TN): Organization of Teratology Information Specialists (OTIS); 1994-. </p></div><div class="iconblock clearfix whole_rhythm no_top_margin bk_noprnt"><a class="img_link icnblk_img" title="Table of Contents Page" href="/books/n/mtb/"><img class="source-thumb" src="/corehtml/pmc/pmcgifs/bookshelf/thumbs/th-mtb-lrg.png" alt="Cover of Mother To Baby | Fact Sheets" height="100px" width="80px" /></a><div class="icnblk_cntnt eight_col"><h2>Mother To Baby | Fact Sheets [Internet].</h2><a data-jig="ncbitoggler" href="#__NBK582651_dtls__">Show details</a><div style="display:none" class="ui-widget" id="__NBK582651_dtls__"><div>Brentwood (TN): <a href="https://mothertobaby.org/fact-sheets/" ref="pagearea=page-banner&targetsite=external&targetcat=link&targettype=publisher">Organization of Teratology Information Specialists (OTIS)</a>; 1994-.</div></div><div class="half_rhythm"></div><div class="bk_noprnt"><form method="get" action="/books/n/mtb/" id="bk_srch"><div class="bk_search"><label for="bk_term" class="offscreen_noflow">Search term</label><input type="text" title="Search this book" id="bk_term" name="term" value="" data-jig="ncbiclearbutton" /> <input type="submit" class="jig-ncbibutton" value="Search this book" submit="false" style="padding: 0.1em 0.4em;" /></div></form></div></div></div></div></div>
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<div class="main-content lit-style" itemscope="itemscope" itemtype="http://schema.org/CreativeWork"><div class="meta-content fm-sec"><h1 id="_NBK582651_"><span class="title" itemprop="name">Codeine</span></h1><p class="small">Published online: April 2023.</p></div><div class="body-content whole_rhythm" itemprop="text"><div id="codeine-en.codeine-en_s_001"><div class="h2"></div><p>This sheet is about exposure to codeine in pregnancy and while breastfeeding. This information is based on available published literature. It should not take the place of medical care and advice from your healthcare provider.</p><p>
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||
<b>
|
||
<i>What is codeine?</i>
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||
</b>
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||
</p><blockquote><p>Codeine is a medication that has been used to treat pain or cough. It belongs to a group of medications called opioids. Opioids are sometimes called narcotics. Some commonly used codeine products also contain other medications, such as acetaminophen. For more information about acetaminophen, please see the MotherToBaby fact sheet at <a href="https://mothertobaby.org/fact-sheets/acetaminophen-pregnancy/" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">https://mothertobaby.org/fact-sheets/acetaminophen-pregnancy/</a>.</p><p>Sometimes when people find out they are pregnant, they think about changing how they take their medication, or stopping their medication altogether. However, it is important to talk with your healthcare providers before making any changes to how you take this medication. Your healthcare providers can talk with you about the benefits of treating your condition and the risks of untreated illness during pregnancy.</p><p>If you have been taking codeine regularly or have a dependency (also called opioid use disorder), you should not just stop taking your medication suddenly (also called “cold turkey”). Stopping an opioid medication suddenly could cause you to go into withdrawal. It is not known how withdrawal might affect a pregnancy. It is suggested that any reduction in codeine be done slowly, and under the direction of your healthcare provider.</p></blockquote><p>
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||
<b>
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||
<i>I take codeine. Can it make it harder for me to get pregnant?</i>
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||
</b>
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||
</p><blockquote><p>A few studies have shown that use or misuse of opioids, including codeine, may cause changes to a person’s menstrual cycle (periods). This could make it harder to get pregnant.</p></blockquote><p>
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||
<b>
|
||
<i>Does taking codeine during pregnancy increase the chance of miscarriage?</i>
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||
</b>
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||
</p><blockquote><p>Miscarriage is common and can occur in any pregnancy for many reasons. It is not known if using codeine can increase the chance of miscarriage.</p></blockquote><p>
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||
<b>
|
||
<i>Does taking codeine increase the chance of birth defects?</i>
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||
</b>
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||
</p><blockquote><p>Every pregnancy starts out with a 3-5% chance of having a birth defect. This is called the background risk. It is not known if taking codeine during pregnancy increases the chance of birth defects above the background risk. A few studies looking at codeine use in pregnancy suggest a possible small increased chance of some birth defects, such as spina bifida (when the fetal spinal cord does not develop as usual) as well as problems with the intestines and/or heart problems. However, studies have not found a specific pattern of birth defects caused by codeine or opioid use in general. If there is an increased chance of birth defects with codeine use in pregnancy, it is likely to be small.</p></blockquote><p>
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||
<b>
|
||
<i>Does taking codeine in pregnancy increase the chance of other pregnancy-related problems?</i>
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||
</b>
|
||
</p><blockquote><p>Studies on the use of opioids during pregnancy have found an increased chance for pregnancy-related problems including poor growth of the baby, stillbirth, preterm delivery (birth before week 37), and the need for a C-section. This is more commonly reported in people who take opioids in higher doses or for longer than recommended by their healthcare providers (i.e., misuse or “abuse” opioids). Codeine might cause postpartum hemorrhage (heavy bleeding after delivery) for some people. Use of an opioid close to the time of delivery can result in withdrawal symptoms in the baby (see the section of this fact sheet on Neonatal Abstinence Syndrome).</p></blockquote><p>
|
||
<b>
|
||
<i>Will my baby have withdrawal (Neonatal Abstinence Syndrome) if I continue to take codeine?</i>
|
||
</b>
|
||
</p><blockquote><p>Neonatal Abstinence Syndrome (NAS) is the term used to describe withdrawal symptoms in newborns from some medication(s) that a person takes during pregnancy. NAS symptoms with opioids can include trouble breathing, extreme drowsiness (sleepiness), poor feeding, irritability, sweating, tremors, vomiting and diarrhea. Most often, symptoms of NAS appear two days after birth and may last more than two weeks. The chance that NAS will occur depends on the length of time and/or the dose of opioid taken during pregnancy. If opioids were taken in pregnancy, it is important to let your baby’s healthcare providers know so that they can check for symptoms of NAS and provide the best care for your newborn.</p></blockquote><p>
|
||
<b>
|
||
<i>Does taking codeine in pregnancy affect future behavior or learning for the child?</i>
|
||
</b>
|
||
</p><blockquote><p>Some studies on opioids as a general group have found more problems with learning and behavior in children exposed to opioids for a long period of time during pregnancy. Those studies have found an increased chance of developmental delay, trouble with memory, and autism-like features. However, it is hard to know if this is due to the medication exposure or other factors that can increase the chances of these problems.</p></blockquote><p>
|
||
<b>
|
||
<i>What if I have been taking more codeine than recommended by my healthcare provider or have an opioid use disorder?</i>
|
||
</b>
|
||
</p><blockquote><p>Talk with your healthcare provider about your codeine use. People who are pregnant and take opioids in higher doses or for longer than recommended by their healthcare providers have an increased chance for issues such as poor fetal growth, stillbirth, preterm delivery, and the need for a C-section.</p></blockquote><p>
|
||
<b>
|
||
<i>Codeine and breastfeeding:</i>
|
||
</b>
|
||
</p><blockquote><p>Codeine passes into breast milk. Some babies might have problems with the amount of medication in the breast milk. There are case reports of codeine use in breastfeeding that have described babies being very sleepy, having trouble latching on, having breathing problems, slower heart rate, and not getting enough oxygen. Other reports describe the use of codeine while breastfeeding without any problems in nursing babies.</p><p>The United States Food and Drug Administration (FDA) recommends that codeine not be used during breastfeeding. Also, the product label for codeine recommends people who are breastfeeding not use this medication. But the benefits of using codeine may outweigh possible risks.</p><p>If you are using codeine (or any opioid), talk to your healthcare provider about how to use the least amount for the shortest time and how to monitor (watch) your baby for any signs of concern. Contact the baby’s healthcare provider immediately if your baby has any problems such as increased sleepiness (more than usual), trouble feeding, trouble breathing, or limpness. Be sure to talk to your healthcare provider about all your breastfeeding questions.</p></blockquote><p>
|
||
<b>
|
||
<i>If a male takes codeine, could it affect fertility or increase the chance of birth defects?</i>
|
||
</b>
|
||
</p><blockquote><p>Use or misuse of opioids, including codeine, has been shown to lower male fertility (ability to get partner pregnant). In general, exposures that fathers or sperm donors have are unlikely to increase risks to a pregnancy. For more information, please see the MotherToBaby fact sheet Paternal Exposures at <a href="https://mothertobaby.org/fact-sheets/paternal-exposures-pregnancy/" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">https://mothertobaby.org/fact-sheets/paternal-exposures-pregnancy/</a>.</p></blockquote></div><div id="R001"><h2 id="_R001_">Selected References</h2><ul class="simple-list"><li class="half_rhythm"><div class="bk_ref" id="c001">Akhigbe
|
||
RE et al, 2022. Codeine alters female reproductive function by targeting ovarian steroidogenesis and folliculogenesis via the induction of oxidative stress, inflammation, and apoptosis, Reproductive Toxicology vol.
|
||
109, 1-9. ISSN 0890-6238 [<a href="https://pubmed.ncbi.nlm.nih.gov/35158039" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 35158039</span></a>]</div></li><li class="half_rhythm"><div class="bk_ref" id="c002">Azuine
|
||
RE et al, 2019. Prenatal risk factors and perinatal and postnatal outcomes associated with maternal opioid exposure in an urban, low-income, multiethnic US population.
|
||
JAMA network
|
||
2(6): e196405-196405. [<a href="/pmc/articles/PMC6604084/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC6604084</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/31251378" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 31251378</span></a>]</div></li><li class="half_rhythm"><div class="bk_ref" id="c003">Berlin, C M Jr et al. 2009. Safety issues of maternal drug therapy during breastfeeding.
|
||
Clinical pharmacology and therapeutics vol. 85,1 (2009): 20-2. [<a href="https://pubmed.ncbi.nlm.nih.gov/19092767" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 19092767</span></a>]</div></li><li class="half_rhythm"><div class="bk_ref" id="c004">Bowie, Alexa C et al. 2022. Prescribed opioid analgesics in early pregnancy and the risk of congenital anomalies: a population-based cohort study.
|
||
CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne vol. 194,5 (2022): E152-E162. [<a href="/pmc/articles/PMC8900758/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC8900758</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/35131753" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 35131753</span></a>]</div></li><li class="half_rhythm"><div class="bk_ref" id="c005">Bracken
|
||
MB.
|
||
1986. Drug use in pregnancy and congenital heart disease in offspring.
|
||
N Engl J Med.
|
||
314(17):1120. [<a href="https://pubmed.ncbi.nlm.nih.gov/3960086" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 3960086</span></a>]</div></li><li class="half_rhythm"><div class="bk_ref" id="c006">Bracken
|
||
MB, Holford
|
||
TR.
|
||
1981. Exposure to prescribed drugs in pregnancy and association with congenital malformations.
|
||
Obstet Gynecol.
|
||
58(3):336-344. [<a href="https://pubmed.ncbi.nlm.nih.gov/7266953" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 7266953</span></a>]</div></li><li class="half_rhythm"><div class="bk_ref" id="c007">Brogly, SB, et al. 2021. Prenatal Opioid Analgesics and the Risk of Adverse Birth Outcomes.
|
||
Epidemiology. 32(3), 448–456. [<a href="/pmc/articles/PMC8011506/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC8011506</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/33625160" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 33625160</span></a>]</div></li><li class="half_rhythm"><div class="bk_ref" id="c008">Broussard
|
||
CS, et al. 2011. Maternal treatment with opioid analgesics and risk for birth defects.
|
||
Am J Obstet Gynecol.
|
||
204(4):314.e1-11. [<a href="https://pubmed.ncbi.nlm.nih.gov/21345403" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 21345403</span></a>]</div></li><li class="half_rhythm"><div class="bk_ref" id="c009">Chow, Cheuk Kiu, et al. 2015. Sedating drugs and breastfeeding.
|
||
Canadian family physician Medecin de famille canadien vol. 61,3 (2015): 241-3. [<a href="/pmc/articles/PMC4369625/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC4369625</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/25927109" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 25927109</span></a>]</div></li><li class="half_rhythm"><div class="bk_ref" id="c010">Corsi
|
||
DJ, et al. 2020. Association of Maternal opioid use in pregnancy with adverse perinatal outcomes in Ontario, Canada, From 2012 to 2018.
|
||
JAMA Netw Open.
|
||
3(7):e208256. [<a href="https://pubmed.ncbi.nlm.nih.gov/32725246" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 32725246</span></a>]</div></li><li class="half_rhythm"><div class="bk_ref" id="c011">Corsi
|
||
DJ, et al. 2021. The Effects of opioids on female fertility, pregnancy and the breastfeeding mother‐infant dyad: A Review.
|
||
Clin Pharm Toxico. [<a href="https://pubmed.ncbi.nlm.nih.gov/33650271" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 33650271</span></a>]</div></li><li class="half_rhythm"><div class="bk_ref" id="c012">Esposito, Daina B et al. 2022. Characteristics of Prescription Opioid Analgesics in Pregnancy and Risk of Neonatal Opioid Withdrawal Syndrome in Newborns.
|
||
JAMA network open vol. 5,8
|
||
e2228588. [<a href="/pmc/articles/PMC9403776/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC9403776</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/36001312" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 36001312</span></a>]</div></li><li class="half_rhythm"><div class="bk_ref" id="c013">Fältmarch
|
||
S, et al. 2019. Use of opioids during pregnancy and effects of pregnancy outcomes.
|
||
Pharmacoepidemiol Drug Saf.
|
||
28: 1239– 1245. [<a href="https://pubmed.ncbi.nlm.nih.gov/31286617" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 31286617</span></a>]</div></li><li class="half_rhythm"><div class="bk_ref" id="c014">European Medicines Agency Sciences Medicines Health.
|
||
2013. Assessment report for codeine-containing medicinal products indicated ... Retrieved April 28, 2023, from <a href="https://www.ema.europa.eu/en/documents/referral/codeine-article-31-referral-prac-assessment-report_en.pdf" ref="pagearea=cite-ref&targetsite=external&targetcat=link&targettype=uri">https://www<wbr style="display:inline-block"></wbr>.ema.europa<wbr style="display:inline-block"></wbr>.eu/en/documents/referral<wbr style="display:inline-block"></wbr>/codeine-article-31-referral-prac-assessment-report<wbr style="display:inline-block"></wbr>_en.pdf</a></div></li><li class="half_rhythm"><div class="bk_ref" id="c015">Fishman
|
||
B, et al. 2019. Pregnancy outcome following opioid exposure: A cohort study.
|
||
PLOS ONE
|
||
14(7): e0219061 [<a href="/pmc/articles/PMC6602193/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC6602193</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/31260464" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 31260464</span></a>]</div></li><li class="half_rhythm"><div class="bk_ref" id="c016">Flannagan, K. S., et al. 2020. Is opioid use safe in women trying to conceive?.
|
||
Epidemiology (Cambridge, Mass.), 31(6), 844–851. [<a href="/pmc/articles/PMC7725439/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC7725439</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/33311959" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 33311959</span></a>]</div></li><li class="half_rhythm"><div class="bk_ref" id="c017">Fronczak
|
||
CM et al, 2012. The insults of illicit drug use on male fertility.
|
||
Journal of andrology.
|
||
33(4): 515-528. [<a href="https://pubmed.ncbi.nlm.nih.gov/21799144" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 21799144</span></a>]</div></li><li class="half_rhythm"><div class="bk_ref" id="c018">Interrante, Julia D et al. 2021. Prescription opioid use during pregnancy and risk for preterm birth or term low birthweight. <em>Journal of opioid management</em> vol. 17,3 (2021): 215-225. [<a href="/pmc/articles/PMC8637424/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC8637424</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/34259333" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 34259333</span></a>]</div></li><li class="half_rhythm"><div class="bk_ref" id="c019">Ito
|
||
S.
|
||
2018. Opioids in Breast Milk: Pharmacokinetic Principles and Clinical Implications.
|
||
The Journal of Clinical Pharmacology,
|
||
58: S151-S163. [<a href="https://pubmed.ncbi.nlm.nih.gov/30248201" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 30248201</span></a>]</div></li><li class="half_rhythm"><div class="bk_ref" id="c020">Juurlink
|
||
DN, et al. 2012. Postpartum maternal codeine therapy and the risk of adverse neonatal outcomes: a retrospective cohort study.
|
||
Clinical Toxicol.
|
||
50:5. [<a href="https://pubmed.ncbi.nlm.nih.gov/22537257" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 22537257</span></a>]</div></li><li class="half_rhythm"><div class="bk_ref" id="c021">Kallen
|
||
B & Reis
|
||
M.
|
||
2015. Use of tramadol in early pregnancy and congenital malformation risk.
|
||
Reprod Toxicol.
|
||
58:246-251. [<a href="https://pubmed.ncbi.nlm.nih.gov/26482725" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 26482725</span></a>]</div></li><li class="half_rhythm"><div class="bk_ref" id="c022">Kelly
|
||
LE, et al. 2013. A clinical tool for reducing central nervous system depression among neonates exposed to codeine through breast milk.
|
||
PLoS ONE.
|
||
8(7):370073. [<a href="/pmc/articles/PMC3726489/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC3726489</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/23922910" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 23922910</span></a>]</div></li><li class="half_rhythm"><div class="bk_ref" id="c023">Khan
|
||
K & Chang
|
||
J.
|
||
1997. Neonatal abstinence syndrome due to codeine.
|
||
Arch Dis Child.
|
||
76:F59-F60. [<a href="/pmc/articles/PMC1720606/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC1720606</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/9059191" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 9059191</span></a>]</div></li><li class="half_rhythm"><div class="bk_ref" id="c024">Konijnenberg, C. el at.
|
||
2022. Verbal and nonverbal memory in school-aged children born to opioid-dependent mothers.
|
||
<em>Early human development</em>, 171, 105614. [<a href="https://pubmed.ncbi.nlm.nih.gov/35772183" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 35772183</span></a>]</div></li><li class="half_rhythm"><div class="bk_ref" id="c025">Lazaryan, Moran et al. 2015. Codeine should not be prescribed for breastfeeding mothers or children under the age of 12.
|
||
Acta paediatrica (Oslo, Norway : 1992) vol. 104,6 (2015): 550-6. [<a href="https://pubmed.ncbi.nlm.nih.gov/25809057" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 25809057</span></a>]</div></li><li class="half_rhythm"><div class="bk_ref" id="c026">Lind
|
||
JN, et al. 2017. Maternal use of opioids during pregnancy and congenital malformations.
|
||
A Systematic Review. Pediatrics.
|
||
139(6):e20164131. [<a href="/pmc/articles/PMC5561453/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC5561453</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/28562278" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 28562278</span></a>]</div></li><li class="half_rhythm"><div class="bk_ref" id="c027">Mactier, H. et al. 2020. Prenatal opioid exposure - Increasing evidence of harm.
|
||
Early human development, 150, 105188. [<a href="https://pubmed.ncbi.nlm.nih.gov/32958331" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 32958331</span></a>]</div></li><li class="half_rhythm"><div class="bk_ref" id="c028">Mangurten
|
||
HH.
|
||
1980. Neonatal codeine withdrawal in infants of non-addicted mothers.
|
||
Pediatrics.
|
||
65:159-160. [<a href="https://pubmed.ncbi.nlm.nih.gov/7355017" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 7355017</span></a>]</div></li><li class="half_rhythm"><div class="bk_ref" id="c029">Meny, R G et al. 1993. Codeine and the breastfed neonate.
|
||
Journal of human lactation : official journal of International Lactation Consultant Association vol. 9,4 (1993): 237-40. [<a href="https://pubmed.ncbi.nlm.nih.gov/8260056" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 8260056</span></a>]</div></li><li class="half_rhythm"><div class="bk_ref" id="c030">Nair
|
||
V, et al. 2012. Neonatal withdrawal syndrome due to maternal codeine use.
|
||
Paediatr Child Health.
|
||
17(5):e40-e41. [<a href="/pmc/articles/PMC3381925/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC3381925</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/23633904" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 23633904</span></a>]</div></li><li class="half_rhythm"><div class="bk_ref" id="c031">Nezvalová-Henriksen
|
||
K, et al. 2011. Effects of codeine on pregnancy outcomes from a large population-based cohort study.
|
||
Eur J Clin Pharmacol.
|
||
67:1253-1261. [<a href="/pmc/articles/PMC3214255/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC3214255</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/21656212" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 21656212</span></a>]</div></li><li class="half_rhythm"><div class="bk_ref" id="c032">Rothman
|
||
KJ, et al. 1979. Exogenous hormones and other drug exposures of children with congenital heart disease.
|
||
Am J Epidemiol.
|
||
109(4):433-439. [<a href="https://pubmed.ncbi.nlm.nih.gov/443241" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 443241</span></a>]</div></li><li class="half_rhythm"><div class="bk_ref" id="c033">Rubenstein, E., et al. 2019. Brief Report: Maternal Opioid Prescription from Preconception Through Pregnancy and the Odds of Autism Spectrum Disorder and Autism Features in Children.
|
||
Journal of autism and developmental disorders, 49(1), 376–382. [<a href="/pmc/articles/PMC6331251/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC6331251</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/30132098" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 30132098</span></a>]</div></li><li class="half_rhythm"><div class="bk_ref" id="c034">Saxén
|
||
I.
|
||
1975. Associations between oral clefts and drugs taken during pregnancy.
|
||
Int J Epidemiol.
|
||
4(1):37-44. [<a href="https://pubmed.ncbi.nlm.nih.gov/1116890" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 1116890</span></a>]</div></li><li class="half_rhythm"><div class="bk_ref" id="c035">Sachs, Hari Cheryl, and Committee On Drugs.
|
||
2013. The transfer of drugs and therapeutics into human breast milk: an update on selected topics.
|
||
Pediatrics vol. 132,3 (2013): e796-809. [<a href="https://pubmed.ncbi.nlm.nih.gov/23979084" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 23979084</span></a>]</div></li><li class="half_rhythm"><div class="bk_ref" id="c036">Shaw
|
||
GM, et al. 1992. Congenital cardiac anomalies relative to selected maternal exposures and conditions during early pregnancy.
|
||
Eur J Epidemiol.
|
||
8(5):757-760. [<a href="https://pubmed.ncbi.nlm.nih.gov/1426180" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 1426180</span></a>]</div></li><li class="half_rhythm"><div class="bk_ref" id="c037">Shaw
|
||
GM, et al. 1998. Maternal illness, including fever and medication use as risk factors for neural tube defects.
|
||
Teratology.
|
||
57(1):1-7. [<a href="https://pubmed.ncbi.nlm.nih.gov/9516745" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 9516745</span></a>]</div></li><li class="half_rhythm"><div class="bk_ref" id="c038">Semet
|
||
M et al, 2017. The impact of drugs on male fertility: a review.
|
||
Andrology,
|
||
5(4), 640-663. [<a href="https://pubmed.ncbi.nlm.nih.gov/28622464" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 28622464</span></a>]</div></li><li class="half_rhythm"><div class="bk_ref" id="c039">Sujan
|
||
AC et al, 2019. Maternal prescribed opioid analgesic use during pregnancy and associations with adverse birth outcomes: A population-based study.
|
||
PLoS Medicine.
|
||
16(12). [<a href="/pmc/articles/PMC6886755/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC6886755</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/31790390" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 31790390</span></a>]</div></li><li class="half_rhythm"><div class="bk_ref" id="c040">U.S. Food and Drug Administration.
|
||
2017. Use of codeine and tramadol products in breastfeeding women – questions and answers. Available at <a href="https://www.fda.gov/Drugs/DrugSafety/PostmarketDrugSafetyInformationforPatientsandProviders/ucm118113.htm" ref="pagearea=cite-ref&targetsite=external&targetcat=link&targettype=uri">https://www<wbr style="display:inline-block"></wbr>.fda.gov/Drugs<wbr style="display:inline-block"></wbr>/DrugSafety/PostmarketDrugSafetyInformationforPatientsandProviders<wbr style="display:inline-block"></wbr>/ucm118113.htm</a>. Accessed November
|
||
27, 2017.</div></li><li class="half_rhythm"><div class="bk_ref" id="c041">Van Leeuwen
|
||
G, et al. 1965. Narcotic withdrawal reaction in a newborn infant due to codeine.
|
||
Pediatrics.
|
||
36:635-636. [<a href="https://pubmed.ncbi.nlm.nih.gov/5890919" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 5890919</span></a>]</div></li><li class="half_rhythm"><div class="bk_ref" id="c042">Willmann, S, et al. 2009. Risk to the breast-fed neonate from codeine treatment to the mother: a quantitative mechanistic modeling study.
|
||
Clin. Pharmacol. Ther.
|
||
86, 634–43. [<a href="https://pubmed.ncbi.nlm.nih.gov/19710640" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 19710640</span></a>]</div></li><li class="half_rhythm"><div class="bk_ref" id="c044">Yazdy
|
||
MM, et al. 2013. Periconceptional use of opioids and the risk of neural tube defects. 2013.
|
||
Obstet Gynecol.
|
||
122(4):838-844. [<a href="/pmc/articles/PMC4557737/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC4557737</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/24084542" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 24084542</span></a>]</div></li><li class="half_rhythm"><div class="bk_ref" id="c045">Zierler
|
||
S, Rothman
|
||
KJ.
|
||
1985. Congenital heart disease in relation to maternal use of Bendectin and other drugs in early pregnancy.
|
||
N Engl J Med.
|
||
313(6):347-352. [<a href="https://pubmed.ncbi.nlm.nih.gov/4010751" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 4010751</span></a>]</div></li><li class="half_rhythm"><div class="bk_ref" id="c046">Zipursky
|
||
J & Juurlink
|
||
DN.
|
||
2020. The Implausibility of Neonatal Opioid Toxicity from Breastfeeding.
|
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Clin Pharmacol Ther. 10.1002/cpt.1882 [<a href="https://pubmed.ncbi.nlm.nih.gov/32378749" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 32378749</span></a>]</div></li></ul></div></div></div>
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