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<div class="pre-content"><div><div class="bk_prnt"><p class="small">NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.</p></div></div></div>
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<div class="main-content lit-style" itemscope="itemscope" itemtype="http://schema.org/Book"><div class="meta-content fm-sec"><div class="iconblock whole_rhythm clearfix no_top_margin"><div class="left label"><img class="source-thumb" src="/corehtml/pmc/pmcgifs/bookshelf/thumbs/th-mlprobe-lrg.png" alt="Cover of Probe Reports from the NIH Molecular Libraries Program" /></div><div class="icnblk_cntnt"><h1 id="_NBK47352_"><span itemprop="name">Probe Reports from the NIH Molecular Libraries Program</span></h1><div class="half_rhythm">Bethesda (MD): <span itemprop="publisher">National Center for Biotechnology Information (US)</span>; <span itemprop="datePublished">2010</span>-.</div><div><a href="/books/about/copyright/">Copyright Notice</a></div></div></div></div><div class="body-content whole_rhythm" itemprop="text"><div itemprop="description"><p>The Molecular Libraries Program (MLP), a component of the NIH Common Fund, offers
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public sector biomedical researchers access to the large-scale screening capacity
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necessary to identify small molecules that can be optimized as chemical probes to
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|
study the functions of genes, cells, and biochemical pathways. This will lead to new
|
|
ways to explore the functions of genes and signaling pathways in health and
|
|
disease.</p><p>The Molecular Libraries Probe Production Centers Network (MLPCN), as part of the MLP,
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|
is a nationwide consortium of small molecule centers that produces innovative
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chemical tools for use in biological research. The MLPCN solicits novel assays from
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the research community for high throughput screening (HTS) against a library of
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350,000 chemically diverse small molecules maintained in a central repository (the
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Molecular Libraries Small Molecule Repository; MLSMR). Validated screening hits are
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optimized by medicinal chemistry to produce useful in vitro chemical probes. All of
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the results from the MLPCN’s activities are deposited into an open access database,
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PubChem, for use in studying biology and disease.</p><p>The MLPCN brings together over 100 experienced medicinal chemists from five academic
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institutions and one NIH intramural center to focus on the development of high
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quality probes from screening hits. The lead medicinal chemists have extensive
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industrial experience from both biotech and large pharmaceutical companies. MLPCN
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probes cover highly diverse targets, biology and disease areas with many probes
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moving on as potential leads in drug discovery efforts after exiting the MLPCN.</p><p>This book brings together structure and biological information on the probes produced
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by the MLPCN in collaboration with the investigators who provided the screening
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assays. This information will be periodically updated with new probe information
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from the active MLPCN Centers.</p></div><div><h2>Contents</h2><ul id="toc_tllNBK47352_toc_y6" class="simple-list toc toc-toggle"><li class="half_rhythm" id="toc_itm_NBK47352_toc_y6"><a class="toc-item" href="/books/n/mlprobe/y6/">Year 6 Reports</a><ul id="toc_lst_NBK47352_toc_y6" class="simple-list toc bktoc_lst_exp"><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml372"><a class="toc-item" href="/books/n/mlprobe/ml372/">SMN Modulator ML372 Increases SMN Protein Abundance, Body Weight, Lifespan, and Rescues Motor Function in SMNΔ7 SMA Mice</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml375"><a class="toc-item" href="/books/n/mlprobe/ml375/">Development of the First Potent, Selective and CNS penetrant M5 Negative Allosteric Modulator (NAM)</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml377"><a class="toc-item" href="/books/n/mlprobe/ml377/">Inhibitors of Myocyte Triacylglyceride Accumulation</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml378"><a class="toc-item" href="/books/n/mlprobe/ml378/">An <i>in Vivo</i> Active Carbamate-based Dual Inhibitor of Lysophospholipase 1 (LYPLA1) and Lysophospholipase 2 (LYPLA2)</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml379"><a class="toc-item" href="/books/n/mlprobe/ml379/">A Candidate Cell-Selective Anticancer Agent</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml380"><a class="toc-item" href="/books/n/mlprobe/ml380/">Development of the First CNS penetrant M5 Positive Allosteric Modulator (PAM) Based on a Novel, non-Isatin Core</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml381"><a class="toc-item" href="/books/n/mlprobe/ml381/">Development of a Novel, Orthosteric M5 Antagonist Possessing a High Degree of Muscarinic Subtype Selectivity</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml382"><a class="toc-item" href="/books/n/mlprobe/ml382/">Discovery and characterization of a small molecule allosteric agonist of MrgX1</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml388"><a class="toc-item" href="/books/n/mlprobe/ml388/">Discovery of two small molecule inhibitors, ML387 and ML388, of human NAD<sup>+</sup>-dependent 15-hydroxyprostaglandin dehydrogenase</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml389"><a class="toc-item" href="/books/n/mlprobe/ml389/">Optimization and characterization of an antagonist for vasopressin 1a (V1a) receptor</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml390"><a class="toc-item" href="/books/n/mlprobe/ml390/">Discovering Small Molecules that Overcome Differentiation Arrest in Acute Myeloid Leukemia</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml392"><a class="toc-item" href="/books/n/mlprobe/ml392/">Inhibitors of the <i>Plasmodium falciparum</i> M17 Leucine Aminopeptidase</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml395"><a class="toc-item" href="/books/n/mlprobe/ml395/">A Next generation PLD2 inhibitor with improved physiochemical properties and DMPK profile for translational in vivo</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml397"><a class="toc-item" href="/books/n/mlprobe/ml397/">The discovery and characterization of a centrally penetrant (ML396) and a peripherally restricted (ML397) pan-Group III mGlu positive allosteric modulators</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml398"><a class="toc-item" href="/books/n/mlprobe/ml398/">Discovery and characterization of ML398, a potent and selective chiral morpholine based antagonist of the dopamine 4 (D<sub>4</sub>) receptor</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml399"><a class="toc-item" href="/books/n/mlprobe/ml399/">Progress towards small molecule inhibitors of the Menin-Mixed Lineage Leukemia (MLL) interaction with in vivo utility</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml400"><a class="toc-item" href="/books/n/mlprobe/ml400/">Allosteric Small Molecule Inhibitors of LMPTP</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml401"><a class="toc-item" href="/books/n/mlprobe/ml401/">Functional Antagonists of EBI-2</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml404"><a class="toc-item" href="/books/n/mlprobe/ml404/">Small Molecules Targeting the Mitochondrial Permeability Transition</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml406"><a class="toc-item" href="/books/n/mlprobe/ml406/">Discovery of small molecule probe that shows anti-tubercular activity via <i>Mtb</i> bioA (DAPA synthase) enzyme inhibition</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml407"><a class="toc-item" href="/books/n/mlprobe/ml407/">Discovery and Evaluation of Fungicidal Anti-Cryptococcal Molecules</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml408"><a class="toc-item" href="/books/n/mlprobe/ml408/">Identification of a chemically validated target in replicating and non-replicating <i>Mycobacterium tuberculosis</i> with the aid of a small molecule probe</a></li></ul></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_y5"><a class="toc-item" href="/books/n/mlprobe/y5/">Year 5 Reports</a><ul id="toc_lst_NBK47352_toc_y5" class="simple-list toc bktoc_lst_exp"><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml370"><a class="toc-item" href="/books/n/mlprobe/ml370/">Discovery of ML370, an inhibitor of <i>Vibrio cholerae</i> Quorum Sensing Acting <i>via</i> the LuxO response regulator</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml369"><a class="toc-item" href="/books/n/mlprobe/ml369/">Inhibitors of the <i>Plasmodium falciparum</i> M18 Aspartyl Aminopeptidase</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml368"><a class="toc-item" href="/books/n/mlprobe/ml368/">ML368 Identification of Imidazopyridines as Selective Inhibitors of the Cytochrome P450 Enzyme CYP3A4</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml367"><a class="toc-item" href="/books/n/mlprobe/ml367/">Discovery of ML367, inhibitor of ATAD5 stabilization</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml366"><a class="toc-item" href="/books/n/mlprobe/ml366/">Discovery of ML366, an inhibitor of <i>Vibrio cholerae</i> Quorum Sensing Acting <i>via</i> the LuxO response regulator</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml365"><a class="toc-item" href="/books/n/mlprobe/ml365/"><b>ML365:</b> Development of Bis-Amides as Selective Inhibitors of the KCNK3/TASK1 Two Pore Potassium Channel</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml360"><a class="toc-item" href="/books/n/mlprobe/ml360/">ML360, A Potent Inhibitor of Lipid Droplet Formation</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml359"><a class="toc-item" href="/books/n/mlprobe/ml359/">Identification of ML359 as a Small Molecule Inhibitor of Protein Disulfide Isomerase</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml358"><a class="toc-item" href="/books/n/mlprobe/ml358/">A high throughput screen for inhibitors of nematode detoxification genes</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml356"><a class="toc-item" href="/books/n/mlprobe/ml356/">Selective inhibitors of FAS-TE</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml355"><a class="toc-item" href="/books/n/mlprobe/ml355/">Discovery of ML355, a Potent and Selective Inhibitor of Human 12-Lipoxygenase</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml354"><a class="toc-item" href="/books/n/mlprobe/ml354/">A Novel and Selective PAR4 Antagonist: ML354</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml353"><a class="toc-item" href="/books/n/mlprobe/ml353/">Identification of a high affinity MPEP-site silent allosteric modulator (SAM) for the metabotropic glutamate subtype 5 receptor (mGlu<sub>5</sub>)</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml351"><a class="toc-item" href="/books/n/mlprobe/ml351/">Discovery of ML351, a Potent and Selective Inhibitor of Human 15-Lipoxygenase-1</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml350"><a class="toc-item" href="/books/n/mlprobe/ml350/">Optimization and characterization of an opioid kappa receptor (OPRK1) antagonist</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml349"><a class="toc-item" href="/books/n/mlprobe/ml349/">Characterization of a Selective, Reversible Inhibitor of Lysophospholipase 2 (LYPLA2)</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml348"><a class="toc-item" href="/books/n/mlprobe/ml348/">Characterization of a Selective, Reversible Inhibitor of Lysophospholipase 1 (LYPLA1)</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml347"><a class="toc-item" href="/books/n/mlprobe/ml347/">Development of a potent and ALK2 selective bone morphogenetic protein receptor (BMP) inhibitor</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml346"><a class="toc-item" href="/books/n/mlprobe/ml346/">ML346: A Novel Modulator of Proteostasis for Protein Conformational Diseases</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml345"><a class="toc-item" href="/books/n/mlprobe/ml345/">ML345, A Small-Molecule Inhibitor of the Insulin-Degrading Enzyme (IDE)</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml344"><a class="toc-item" href="/books/n/mlprobe/ml344/">Discovery of Two, Structurally Distinct Agonists of <i>Vibrio cholerae</i> Quorum Sensing Acting <i>via</i> the CqsS Membrane Receptor</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml342"><a class="toc-item" href="/books/n/mlprobe/ml342/">Inhibitors of FAP-fluorogen interaction as a multiplex assay tool compound for receptor internalization assays</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml341"><a class="toc-item" href="/books/n/mlprobe/ml341/">Identification of Diversity-Oriented Synthesis Derived Small Molecule, ML341, with Cidal Activity Against <i>Trypanosoma cruzi</i></a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml340"><a class="toc-item" href="/books/n/mlprobe/ml340/">Small-molecule antagonists of Gli function</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml339"><a class="toc-item" href="/books/n/mlprobe/ml339/">Probing the CXCR6/CXCL16 Axis: Targeting Prevention of Prostate Cancer Metastasis</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml338"><a class="toc-item" href="/books/n/mlprobe/ml338/">Elucidation of the physiology of non-replicating, drug tolerant <i>Mycobacterium tuberculosis</i> with the aid of the small molecule probe ML338</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml337"><a class="toc-item" href="/books/n/mlprobe/ml337/">Development of a Second Generation mGlu<sub>3</sub> NAM Probe</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml336"><a class="toc-item" href="/books/n/mlprobe/ml336/">ML336: Development of Quinazolinone-Based Inhibitors Against Venezuelan Equine Encephalitis Virus (VEEV)</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml335"><a class="toc-item" href="/books/n/mlprobe/ml335/">Characterization of an agonist probe for opioid receptor mu 1 (OPRM1)-opioid receptor delta 1 (OPRD1) heterodimerization</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml334"><a class="toc-item" href="/books/n/mlprobe/ml334/">The identification and characterization of non-reactive inhibitor of Keap1-Nrf2 interaction through HTS using a fluorescence polarization assay</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml333"><a class="toc-item" href="/books/n/mlprobe/ml333/">N-(pyridin-4-yl)benzo[d]thiazole-6-carboxamide inhibits <i>E. coli</i> UT189 bacterial capsule biogenesis</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml332"><a class="toc-item" href="/books/n/mlprobe/ml332/">Identification of a glycine sulfonamide based non-MPEP site positive allosteric potentiator (PAM) of mGlu<sub>5</sub></a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml331"><a class="toc-item" href="/books/n/mlprobe/ml331/">Cardioprotective inhibitors of reperfusion injury</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml329"><a class="toc-item" href="/books/n/mlprobe/ml329/">A Small Molecule Inhibitor of the MITF Molecular Pathway</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml328"><a class="toc-item" href="/books/n/mlprobe/ml328/">ML328: A Novel Dual Inhibitor of Bacterial AddAB and RecBCD Helicase-nuclease DNA Repair Enzymes</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml323"><a class="toc-item" href="/books/n/mlprobe/ml323/">Discovery of ML323 as a Novel Inhibitor of the USP1/UAF1 Deubiquitinase Complex</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml327"><a class="toc-item" href="/books/n/mlprobe/ml327/">Discovery and characterization of a small molecule that restores E-cadherin expression in cancer cell lines via a new mechanism</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml326"><a class="toc-item" href="/books/n/mlprobe/ml326/">Development and characterization of a highly selective M5 PAM probe molecule with improved potency</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml325"><a class="toc-item" href="/books/n/mlprobe/ml325/">Optimization and characterization of a pan protein arginine deiminase (PAD) inhibitor</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml324"><a class="toc-item" href="/books/n/mlprobe/ml324/">Discovery of ML324, a JMJD2 demethylase inhibitor with demonstrated antiviral activity</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml322"><a class="toc-item" href="/books/n/mlprobe/ml322/">ML322, A Small Molecule Inhibitor of Dimerization of the Core Protein of Hepatitis C Virus (HCV)</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml321"><a class="toc-item" href="/books/n/mlprobe/ml321/">Discovery, optimization, and characterization of a novel series of dopamine D<sub>2</sub> versus D<sub>3</sub> receptor selective antagonists</a></li></ul></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_y4"><a class="toc-item" href="/books/n/mlprobe/y4/">Year 4 Reports</a><ul id="toc_lst_NBK47352_toc_y4" class="simple-list toc bktoc_lst_exp"><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml320"><a class="toc-item" href="/books/n/mlprobe/ml320/">Discovery of Potent and Highly Selective Inhibitors of GSK3b</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml318"><a class="toc-item" href="/books/n/mlprobe/ml318/">Identification of a small molecule inhibitor of Pseudomonas aeruginosa PvdQ acylase, an enzyme involved in siderophore pyoverdine synthesis</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml317"><a class="toc-item" href="/books/n/mlprobe/ml317/">3-(2,6-difluorobenzamido)-5-(4-ethoxyphenyl) thiophene-2-carboxylic acid inhibits <i>E.coli</i> UT189 bacterial capsule biogenesis</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml316"><a class="toc-item" href="/books/n/mlprobe/ml316/">Probing Metabolic Requirements for Fungal Virulence — Probe 1</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml315"><a class="toc-item" href="/books/n/mlprobe/ml315/">Identification of selective inhibitors of cdc2-like kinases 1 and 4 (Clk1, Clk4)</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml314"><a class="toc-item" href="/books/n/mlprobe/ml314/">Small Molecule Agonists for the Neurotensin 1 Receptor (NTR1 Agonists)</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml312"><a class="toc-item" href="/books/n/mlprobe/ml312/">A Small Molecule Inhibitor of Scavenger Receptor BI-mediated Lipid Uptake - Probe 3</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml311"><a class="toc-item" href="/books/n/mlprobe/ml311/">ML311: A Small Molecule that Potently and Selectively Disrupts the Protein-Protein Interaction of Mcl-1 and Bim: A Probe for Studying Lymphoid Tumorigenesis</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml310"><a class="toc-item" href="/books/n/mlprobe/ml310/">Identification of a novel selective inverse agonist probe and analogs for the Retinoic acid receptor-related Orphan Receptor Gamma (RORγ)</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml309"><a class="toc-item" href="/books/n/mlprobe/ml309/">ML309: A potent inhibitor of R132H mutant IDH1 capable of reducing 2-hydroxyglutarate production in U87 MG glioblastoma cells</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml308"><a class="toc-item" href="/books/n/mlprobe/ml308/">Development of a Selective Chemical Inhibitor for the Two-Pore Potassium Channel, KCNK9</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml307"><a class="toc-item" href="/books/n/mlprobe/ml307/">Selective UBC 13 Inhibitors</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml306"><a class="toc-item" href="/books/n/mlprobe/ml306/">Discovery of Novel General Anesthetics Using Apoferritin as a Surrogate System</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml304"><a class="toc-item" href="/books/n/mlprobe/ml304/">A 2nd Selective Inhibitor of <i>Plasmodium falciparum</i> Glucose-6-Phosphate
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Dehydrogenase (<i>Pf</i>G6PDH) - Probe 2</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml303"><a class="toc-item" href="/books/n/mlprobe/ml303/">Discovery of Small Molecule Influenza Virus NS1 Antagonist</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml302"><a class="toc-item" href="/books/n/mlprobe/ml302/">ML302, a Novel Beta-lactamase (BLA) Inhibitor</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml300"><a class="toc-item" href="/books/n/mlprobe/ml300/">Non-covalent triazole-based inhibitors of the SARS main proteinase 3CLpro</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml299"><a class="toc-item" href="/books/n/mlprobe/ml299/">Development of a Selective, Allosteric PLD1/2 Inhibitor in a Novel Scaffold</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml298"><a class="toc-item" href="/books/n/mlprobe/ml298/">Development of a Selective, Allosteric PLD2 Inhibitor</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml297"><a class="toc-item" href="/books/n/mlprobe/ml297/">Discovery and Characterization of a Selective Activator of the G-Protein Activated Inward-Rectifying Potassium (GIRK) Channel</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml296"><a class="toc-item" href="/books/n/mlprobe/ml296/">Optimization and characterization of triazole urea inhibitors for abhydrolase domain containing protein 6 (ABHD6)</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml294"><a class="toc-item" href="/books/n/mlprobe/ml294/">Optimization and characterization of a triazole urea inhibitor for diacylglycerol lipase beta (DAGL-β)</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml293"><a class="toc-item" href="/books/n/mlprobe/ml293/">Discovery of a novel structural class of M4 positive allosteric modulators: Characterization of ML293, <i>N</i>-(4-methoxy-7-methylbenzo[d]thiazol-2-yl)isonicotinamide, with CNS exposure in rats</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml292"><a class="toc-item" href="/books/n/mlprobe/ml292/">Discovery of a novel metabotropic glutamate receptor 4 (mGlu<sub>4</sub>)
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positive allosteric modulator (PAM) extended probe: Characterization of ML292, a potent and selective mGlu<sub>4</sub> PAM which
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produces efficacy alone or in combination with L-DOPA in preclinical rodent models
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of Parkinson's disease</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml291"><a class="toc-item" href="/books/n/mlprobe/ml291/">Selective small molecule activator of the apoptotic arm of the UPR</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml290"><a class="toc-item" href="/books/n/mlprobe/ml290/">Discovery, optimization, and biological activity of the first potent and selective small-molecule agonist series of human relaxin receptor 1 (RXFP1)</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml289"><a class="toc-item" href="/books/n/mlprobe/ml289/">Development of the First Selective mGlu<sub>3</sub> NAM from an mGlu<sub>5</sub> PAM Hit</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml285"><a class="toc-item" href="/books/n/mlprobe/ml285/">ML285 affects reactive oxygen species’ inhibition of pyruvate kinase M2</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml283"><a class="toc-item" href="/books/n/mlprobe/ml283/">Hepatitis C Virus NS3 Helicase Inhibitor Discovery</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml282"><a class="toc-item" href="/books/n/mlprobe/ml282/">A small molecule pan-inhibitor of Ras-superfamily GTPases with high efficacy towards Rab7</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml281"><a class="toc-item" href="/books/n/mlprobe/ml281/">Screen for Inhibitors of STK33 Kinase Activity</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml279"><a class="toc-item" href="/books/n/mlprobe/ml279/">A Small Molecule Inhibitor of Scavenger Receptor BI-mediated Lipid Uptake—Probe 2</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml278"><a class="toc-item" href="/books/n/mlprobe/ml278/">A Small Molecule Inhibitor of Scavenger Receptor BI-mediated Lipid Uptake—Probe 1</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml277"><a class="toc-item" href="/books/n/mlprobe/ml277/">Identification of a novel, small molecule activator of KCNQ1 channels</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml276"><a class="toc-item" href="/books/n/mlprobe/ml276/">A Selective Inhibitor of <i>Plasmodium falciparum</i> Glucose-6-Phosphate Dehydrogenase (<i>Pf</i>G6PDH)</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml275"><a class="toc-item" href="/books/n/mlprobe/ml275/">Identification of a Series of Quinazolinediones as Potent, Selective, Post-Entry Inhibitors of Human Respiratory Syncytial Virus (<i>h</i>RSV) via a Cell-Based High Throughput Screen and Chemical Optimization</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml273"><a class="toc-item" href="/books/n/mlprobe/ml273/">Identification of a Selective Allosteric Agonist of mGlu<sub>5</sub></a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml269"><a class="toc-item" href="/books/n/mlprobe/ml269/">Identification of Selective Agonists of the Transient Receptor Potential Channels 3 (TRPML3)</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml267"><a class="toc-item" href="/books/n/mlprobe/ml267/">Discovery of <b>ML 267</b> as a Novel Inhibitor of Pathogenic Sfp phosphopantetheinyl transferase (PPTase)</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml266"><a class="toc-item" href="/books/n/mlprobe/ml266/">Discovery, SAR, and Biological Evaluation of Non-inhibitory Chaperones of Glucocerebrosidase</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml265"><a class="toc-item" href="/books/n/mlprobe/ml265/">ML265: A potent PKM2 activator induces tetramerization and reduces tumor formation and size in a mouse xenograft model</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml264"><a class="toc-item" href="/books/n/mlprobe/ml264/">ML264: An Antitumor Agent that Potently and Selectively Inhibits Krüppel-like Factor Five (KLF5) Expression: A Probe for Studying Colon Cancer Development and Progression</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml262"><a class="toc-item" href="/books/n/mlprobe/ml262/">Potent inhibitors of lipid droplet formation</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml260"><a class="toc-item" href="/books/n/mlprobe/ml260/">A Selective Murine Intestinal Alkaline Phosphatase (muIAP) Inhibitor</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml258"><a class="toc-item" href="/books/n/mlprobe/ml258/">Selective Bcl-2 Inhibitor Probes</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml257"><a class="toc-item" href="/books/n/mlprobe/ml257/">Probe Development Efforts to Identify Novel Inhibitors of ABHD10</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml256"><a class="toc-item" href="/books/n/mlprobe/ml256/">Optimization and characterization of a carbamate inhibitor for plasma platelet-activating factor acetylhydrolase (pPAFAH)</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml254"><a class="toc-item" href="/books/n/mlprobe/ml254/">Pure Positive Allosteric Modulators (PAMs) of mGlu5 with Competitive MPEP-Site Interaction</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml253"><a class="toc-item" href="/books/n/mlprobe/ml253/">Extended Probe Characterization: Development of an M<sub>4</sub> PAM with Improved Activity and Brain Exposure, while Avoiding Species Bias</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml252"><a class="toc-item" href="/books/n/mlprobe/ml252/">Identification of a novel, small molecule inhibitor of KCNQ2 channels</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml251"><a class="toc-item" href="/books/n/mlprobe/ml251/">Identification of Selective Inhibitors of Phosphofructokinase as Lead Compounds Against Trypanosomiasis</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml250"><a class="toc-item" href="/books/n/mlprobe/ml250/">Optimization and Characterization of a Second Antagonist for G-protein Coupled Receptor 7 (GPR7)</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml249"><a class="toc-item" href="/books/n/mlprobe/ml249/">Probe Development Efforts for an Allosteric Agonist of the Sphingosine 1-phosphate Receptor 3 (S1P3)</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml248"><a class="toc-item" href="/books/n/mlprobe/ml248/">Identification of a Novel Agonist of the Sphingosine 1-phosphate Receptor 4 (S1P4)</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml247"><a class="toc-item" href="/books/n/mlprobe/ml247/">Discovery, SAR, and Biological Evaluation of a Non-Inhibitory Chaperone for Acid Alpha Glucosidase</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml246"><a class="toc-item" href="/books/n/mlprobe/ml246/">Discovery and Development of Small Molecules That Reduce PNC Prevalence</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml245"><a class="toc-item" href="/books/n/mlprobe/ml245/">Identification of a Selective Small-Molecule Inhibitor of Breast Cancer Stem Cells—Probe 2</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml243"><a class="toc-item" href="/books/n/mlprobe/ml243/">Identification of a Selective Small-Molecule Inhibitor of Breast Cancer Stem Cells - Probe 3</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml239"><a class="toc-item" href="/books/n/mlprobe/ml239/">Identification of a Selective Small-Molecule Inhibitor of Breast Cancer Stem Cells - Probe 1</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml227"><a class="toc-item" href="/books/n/mlprobe/ml227/">Inhibitors of the Menin-Mixed Lineage Leukemia (MLL) Interaction</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml224"><a class="toc-item" href="/books/n/mlprobe/ml224/">Identification of Thyroid Stimulating Hormone Receptor Inverse Agonists</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml223"><a class="toc-item" href="/books/n/mlprobe/ml223/">ML223: A Small Molecule Probe With <i>In Vivo</i> Activity Against Acute Myeloid Leukemia Subtype M4Eo</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml188"><a class="toc-item" href="/books/n/mlprobe/ml188/">Discovery of non-covalent inhibitors of the SARS main proteinase 3CLpro</a></li></ul></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_y3"><a class="toc-item" href="/books/n/mlprobe/y3/">Year 3 Reports</a><ul id="toc_lst_NBK47352_toc_y3" class="simple-list toc bktoc_lst_exp"><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml244"><a class="toc-item" href="/books/n/mlprobe/ml244/">Potent Anti-Diabetic Actions of a Novel Non-Agonist PPARγ Ligand that Blocks Cdk5-Mediated Phosphorylation</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml242"><a class="toc-item" href="/books/n/mlprobe/ml242/">Discovery and Development of Highly Potent Inhibitors of <i>Mycobacterium tuberculosis</i> Growth <i>In Vitro</i></a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml241"><a class="toc-item" href="/books/n/mlprobe/ml241/">Selective, reversible inhibitors of the AAA ATPase p97</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml238"><a class="toc-item" href="/books/n/mlprobe/ml238/">ML238: An Antimalarial Small Molecule of a Unique Structural Class</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml237"><a class="toc-item" href="/books/n/mlprobe/ml237/">B-cell Specific Inhibitors of NF-κB Activation</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml233"><a class="toc-item" href="/books/n/mlprobe/ml233/">Functional Agonists of the Apelin (APJ) Receptor</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml232"><a class="toc-item" href="/books/n/mlprobe/ml232/">A Cell Based HTS Approach for the Discovery of New Inhibitors of RSV</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml231"><a class="toc-item" href="/books/n/mlprobe/ml231/">Profiling a Selective Probe for RTG Branch of Yeast TORC1 Signaling Pathway</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml230"><a class="toc-item" href="/books/n/mlprobe/ml230/">Selective Efflux Inhibition of ATP-binding Cassette Sub-family G Member 2</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml229"><a class="toc-item" href="/books/n/mlprobe/ml229/">Identification of Small Molecules that Selectively Inhibit Fluconazole-Resistant
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<i>Candida Albicans</i> in the Presence of Fluconazole but not in its
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Absence - Probe 3</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml228"><a class="toc-item" href="/books/n/mlprobe/ml228/">Discovery of a Small Molecule Activator of the Hypoxia Inducible Factor Pathway</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml226"><a class="toc-item" href="/books/n/mlprobe/ml226/">Optimization and characterization of a triazole urea inhibitor for alpha/beta hydrolase domain-containing protein 11 (ABHD11): anti-probe for LYPLA1/LYPLA2 dual inhibitor ML211</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml225"><a class="toc-item" href="/books/n/mlprobe/ml225/">Optimization and characterization of a triazole urea inhibitor for platelet-activating factor acetylhydrolase type 2 (PAFAH2)</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml221"><a class="toc-item" href="/books/n/mlprobe/ml221/">Functional antagonists of the Apelin (APJ) receptor</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml220"><a class="toc-item" href="/books/n/mlprobe/ml220/">Modulators of Lipid Storage</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml218"><a class="toc-item" href="/books/n/mlprobe/ml218/">Scaffold Hopping Affords a Highly Selective <i>in vitro</i> and <i>in vivo</i> T-Type Calcium Inhibitor Probe Free From IP Issues</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml217"><a class="toc-item" href="/books/n/mlprobe/ml217/">Reversible and non-covalent benzimidazole-based <i>in vivo</i> lead for Chagas disease</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml216"><a class="toc-item" href="/books/n/mlprobe/ml216/">Discovery of ML216, a Small Molecule Inhibitor of Bloom (BLM) Helicase</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml214"><a class="toc-item" href="/books/n/mlprobe/ml214/">Discovery of Inhibitors of Anti-Apoptotic Protein A1</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml213"><a class="toc-item" href="/books/n/mlprobe/ml213/">A small molecule activator of KCNQ2 and KCNQ4 channels</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml212"><a class="toc-item" href="/books/n/mlprobe/ml212/">Identification of small molecules that selectively inhibit fluconazole-resistant
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<i>Candida albicans</i> in the presence of fluconazole but not in its
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absence - Probe 2</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml211"><a class="toc-item" href="/books/n/mlprobe/ml211/">Optimization and characterization of a triazole urea dual inhibitor for lysophospholipase 1 (LYPLA1) and lysophospholipase 2 (LYPLA2)</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml210"><a class="toc-item" href="/books/n/mlprobe/ml210/">Screen for RAS-Selective Lethal Compounds and VDAC Ligands - Probe 2</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml209"><a class="toc-item" href="/books/n/mlprobe/ml209/">Identification of Potent and Selective RORγ Antagonists</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml205"><a class="toc-item" href="/books/n/mlprobe/ml205/">Identification of Inhibitors of <i>Trypanosoma brucei</i> Hexokinases</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml204"><a class="toc-item" href="/books/n/mlprobe/ml204/">Novel Chemical Inhibitor of TRPC4 Channels</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml201"><a class="toc-item" href="/books/n/mlprobe/ml201/">5-(4-(4-Acetylphenyl)piperazin-1-ylsulfonyl)indolin-2-one Analogs as Inhibitors of Acid alpha-Glucosidase for Potential Chaperone Treatment of Pompe Disease or Intervention for Diabetes Mellitus Type 2</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml199"><a class="toc-item" href="/books/n/mlprobe/ml199/">Small Molecule Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1)</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml194"><a class="toc-item" href="/books/n/mlprobe/ml194/">Selective GPR35 Antagonists - Probe 3</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml193"><a class="toc-item" href="/books/n/mlprobe/ml193/">Screening for Selective Ligands for GPR55 - Antagonists</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml190"><a class="toc-item" href="/books/n/mlprobe/ml190/">Antagonist for the Kappa Opioid Receptor</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml189"><a class="toc-item" href="/books/n/mlprobe/ml189/">Identification of small molecules that selectively inhibit fluconazole-resistant <i>Candida albicans</i> in the presence of fluconazole but not in its absence</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml187"><a class="toc-item" href="/books/n/mlprobe/ml187/">Identification of Small Molecule Inhibitors that Suppress Cytokine-Induced Apoptosis in Human Pancreatic Islet Cells</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml186"><a class="toc-item" href="/books/n/mlprobe/ml186/">Screening for Selective Ligands for GPR55 - Agonists</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml182"><a class="toc-item" href="/books/n/mlprobe/ml182/">Discovery of a potent, selective and orally active <i>in vivo</i> mGlu<sub>4</sub> positive allosteric modulator</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml181"><a class="toc-item" href="/books/n/mlprobe/ml181/">Optimization and Characterization of an Antagonist for G-Protein Coupled Receptor 7 (GPR7)</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml180"><a class="toc-item" href="/books/n/mlprobe/ml180/">Discovery of Inverse Agonists for the Liver Receptor Homologue-1 (LRH1; NR5A2)</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml178"><a class="toc-item" href="/books/n/mlprobe/ml178/">Probe Development Efforts to Identify Novel Agonists of the Sphingosine 1-phosphate Receptor 4 (S1P4)</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml177"><a class="toc-item" href="/books/n/mlprobe/ml177/">Identification of Small Molecule Inhibitors of Wee1 Degradation and Mitotic Entry</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml176"><a class="toc-item" href="/books/n/mlprobe/ml176/">Identification of a novel selective inverse agonist probe and analogs for the Retinoic acid receptor-related Orphan Receptor Alpha (RORα)</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml175"><a class="toc-item" href="/books/n/mlprobe/ml175/">Optimization and Characterization of an Inhibitor for Glutathione S-Tranferase Omega 1 (GSTO1)</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml174"><a class="toc-item" href="/books/n/mlprobe/ml174/">Probe Development Efforts to Identify Novel Inhibitors of Protein Phosphatase Methylesterase-1 (PME-1)</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml173"><a class="toc-item" href="/books/n/mlprobe/ml173/">Discovery of a Highly Selective <i>in vitro</i> and <i>in vivo</i> M<sub>4</sub> Positive Allosteric Modulator (PAM) Series with Greatly Improved Human Receptor Activity</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml172"><a class="toc-item" href="/books/n/mlprobe/ml172/">Development of the First Highly Selective mAChR 5 (M<sub>5</sub>) Positive Allosteric Modulator (PAM)</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml171"><a class="toc-item" href="/books/n/mlprobe/ml171/">Optimization and Characterization of an Inhibitor for NADPH Oxidase 1 (NOX-1)</a></li></ul></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_y2"><a class="toc-item" href="/books/n/mlprobe/y2/">Year 2 Reports</a><ul id="toc_lst_NBK47352_toc_y2" class="simple-list toc bktoc_lst_exp"><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml200"><a class="toc-item" href="/books/n/mlprobe/ml200/">Discovery, SAR and Biological Evaluation of Aryl-thiazol-piperidines as SMN Modulators</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml183"><a class="toc-item" href="/books/n/mlprobe/ml183/">Antagonists of IAP-family anti-apoptotic proteins - Probe 2</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml170"><a class="toc-item" href="/books/n/mlprobe/ml170/">Identification of activators for the M2 isoform of human pyruvate kinase Version 3</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml169"><a class="toc-item" href="/books/n/mlprobe/ml169/">Discovery and development of a second highly selective M<sub>1</sub> Positive Allosteric Modulator (PAM)</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml168"><a class="toc-item" href="/books/n/mlprobe/ml168/">Identification of compounds which inhibit cytotoxicity associated with mutant Huntingtin protein expression</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml167"><a class="toc-item" href="/books/n/mlprobe/ml167/">An inhibitor of the Cdc2-like kinase 4 (Clk4)</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml165"><a class="toc-item" href="/books/n/mlprobe/ml165/">Inhibitors of Platelet Integrin αllbβ3</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml164"><a class="toc-item" href="/books/n/mlprobe/ml164/">Identification of Small-Molecule Inhibitors of <i>Trypansoma cruzi</i> Infection - Probe 1</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml163"><a class="toc-item" href="/books/n/mlprobe/ml163/">Identification of a small molecule that selectively activates alpha-synuclein translational expression</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml162"><a class="toc-item" href="/books/n/mlprobe/ml162/">Screen for RAS-Selective Lethal Compounds and VDAC Ligands - Probe 1</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml161"><a class="toc-item" href="/books/n/mlprobe/ml161/">Chemical Genetic Analysis of Platelet Granule Secretion-Probe 3</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml160"><a class="toc-item" href="/books/n/mlprobe/ml160/">Chemical Genetic Analysis of Platelet Granule Secretion-Probe 2</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml159"><a class="toc-item" href="/books/n/mlprobe/ml159/">Chemical Genetic Analysis of Platelet Granule Secretion-Probe 1</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml158"><a class="toc-item" href="/books/n/mlprobe/ml158/">Identification of Small-Molecule Inhibitors of <i>Trypansoma cruzi</i> Infection - Probe 3</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml157"><a class="toc-item" href="/books/n/mlprobe/ml157/">Identification of Small-Molecule Inhibitors of <i>Trypansoma cruzi</i> Infection</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml156"><a class="toc-item" href="/books/n/mlprobe/ml156/">Identification of Modulators of the N370S Mutant Form of Glucocerebrosidase as a Potential Therapy for Gaucher Disease - Chemotype 2</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml155"><a class="toc-item" href="/books/n/mlprobe/ml155/">Identification of Modulators of the N370S Mutant Form of Glucocerebrosidase as a Potential Therapy for Gaucher Disease - Chemotype 1</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml154"><a class="toc-item" href="/books/n/mlprobe/ml154/">Identification of Small Molecule Antagonists of the Neuropeptide-S Receptor</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml152"><a class="toc-item" href="/books/n/mlprobe/ml152/">Toward Improved Therapy for Classic Galactosemia</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml151"><a class="toc-item" href="/books/n/mlprobe/ml151/">qHTS for Inhibitors of the Interaction of Thyroid Hormone Receptor and Steroid Receptor Coregulator 2</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml150"><a class="toc-item" href="/books/n/mlprobe/ml150/">Identification of a small molecule that selectively inhibits alpha-synuclein translational expression</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml149"><a class="toc-item" href="/books/n/mlprobe/ml149/">Potent and selective inhibitors of NAD<sup>+</sup>-dependent
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15-hydroxyprostaglandin dehydrogenase (HPGD)</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml146"><a class="toc-item" href="/books/n/mlprobe/ml146/">High Throughput Screening Assays for NOD1 Inhibitors - Probe 2</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml145"><a class="toc-item" href="/books/n/mlprobe/ml145/">Selective GPR35 Antagonists - Probes 1 & 2</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml143"><a class="toc-item" href="/books/n/mlprobe/ml143/">A Cell Based Assay for the Identification of Lead Compounds with Anti-Viral Activity Against West Nile Virus</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml141"><a class="toc-item" href="/books/n/mlprobe/ml141/">A Potent and Selective Inhibitor of Cdc42 GTPase</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml140"><a class="toc-item" href="/books/n/mlprobe/ml140/">Selective KOP Receptor Antagonists: Probe 1</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml139"><a class="toc-item" href="/books/n/mlprobe/ml139/">Selective KOP Receptor Agonists: Probe 1 & Probe 2</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml137"><a class="toc-item" href="/books/n/mlprobe/ml137/">Discovery and development of the a highly selective M<sub>1</sub> Positive Allosteric Modulator (PAM)</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml136"><a class="toc-item" href="/books/n/mlprobe/ml136/">Probe Report for PME-1 Inhibitors</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml135"><a class="toc-item" href="/books/n/mlprobe/ml135/">Identification of small molecules that selectively inhibit streptokinase expression without suppression of viability in Group A streptococci - Probe 3</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml134"><a class="toc-item" href="/books/n/mlprobe/ml134/">Identification of small molecules that selectively inhibit streptokinase expression without suppression of viability in Group A streptococci - Probe 2</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml133"><a class="toc-item" href="/books/n/mlprobe/ml133/">A potent and selective small molecule Kir2.1 inhibitor</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml132"><a class="toc-item" href="/books/n/mlprobe/ml132/">A small molecule inhibitor of Caspase 1</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml131"><a class="toc-item" href="/books/n/mlprobe/ml131/">Probe Development Efforts to Identify Novel Antagonists of the Sphingosine 1-phosphate Receptor 4 (S1P4)</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml130"><a class="toc-item" href="/books/n/mlprobe/ml130/">High Throughput Screening Assays for NOD1 Inhibitors - Probe 1</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml129"><a class="toc-item" href="/books/n/mlprobe/ml129/">Discovery of the first mAChR 5 (M5) selective ligand, an M5 Positive Allosteric Modulator (PAM)</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml128"><a class="toc-item" href="/books/n/mlprobe/ml128/">Discovery of a potent, selective and <i>in vivo</i> active mGluR4 positive allosteric modulator</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml127"><a class="toc-item" href="/books/n/mlprobe/ml127/">Selective Small Molecule Inhibitors of 12-Human Lipoxygenase (12-hLO)</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml126"><a class="toc-item" href="/books/n/mlprobe/ml126/">Identification of small molecules that selectively inhibit streptokinase expression without suppression of viability in Group A streptococci - Probe 1</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml125"><a class="toc-item" href="/books/n/mlprobe/ml125/">Campaign to identify novel modulators of the Retinoic acid receptor-related Orphan Receptors (ROR)</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml123"><a class="toc-item" href="/books/n/mlprobe/ml123/">Campaign to Identify Agonists of Transient Receptor Potential Channels 3 and 2 (TRPML3 & TRPML2)</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml121"><a class="toc-item" href="/books/n/mlprobe/ml121/">HTS Assay for Discovery of Novel Metallo-Beta-lactamase (MBL) Inhibitors</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml120"><a class="toc-item" href="/books/n/mlprobe/ml120/">Selective HePTP Inhibitors: Probe 2</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml119"><a class="toc-item" href="/books/n/mlprobe/ml119/">Selective HePTP Inhibitors: Probe 1</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml118"><a class="toc-item" href="/books/n/mlprobe/ml118/">Small Molecule Inhibitors of Wee1 Degradation and Mitotic Entry</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml116"><a class="toc-item" href="/books/n/mlprobe/ml116/">Modulators of STAT Transcription Factors for the Targeted Therapy of Cancer (STAT3 Inhibitors)</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml115"><a class="toc-item" href="/books/n/mlprobe/ml115/">Modulators of STAT Transcription Factors for the Targeted Therapy of Cancer (STAT3 Activators)</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml114"><a class="toc-item" href="/books/n/mlprobe/ml114/">Probe Report for RBBP9 Inhibitors - Probe 2</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml113"><a class="toc-item" href="/books/n/mlprobe/ml113/">Small-Molecule Inhibitors of Vaccinia-H1-Related Phosphatase VHR</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml112"><a class="toc-item" href="/books/n/mlprobe/ml112/">Discovery of a small molecule inhibitor of ROMK with unprecedented selectivity</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml111"><a class="toc-item" href="/books/n/mlprobe/ml111/">Discovery of a small molecule inhibitor of ROMK and Kir7.1</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml109"><a class="toc-item" href="/books/n/mlprobe/ml109/">Identification of Potent and Selective Thyroid Stimulating Hormone Receptor Agonists</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml108"><a class="toc-item" href="/books/n/mlprobe/ml108/">Discovery of a Highly Selective <i>in vitro</i> and <i>in vivo</i> M4 Positive Allosteric Modulator (PAM)</a></li></ul></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_y1"><a class="toc-item" href="/books/n/mlprobe/y1/">Year 1 Reports</a><ul id="toc_lst_NBK47352_toc_y1" class="simple-list toc bktoc_lst_exp"><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml106"><a class="toc-item" href="/books/n/mlprobe/ml106/">A high-throughput screen for pre-mRNA splicing modulators</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml104"><a class="toc-item" href="/books/n/mlprobe/ml104/">High throughput screening for SMA</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml103"><a class="toc-item" href="/books/n/mlprobe/ml103/">High Throughput Screening for Small Molecule Inhibitors of Heparin-induced Tau Fibril Formation</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml102"><a class="toc-item" href="/books/n/mlprobe/ml102/">HTS for Identification of Inhibitors against the ERK Signaling Pathway using a Homogenous Cell-based Assay</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml101"><a class="toc-item" href="/books/n/mlprobe/ml101/">Antagonists of IAP-family anti-apoptotic proteins - Probe 1</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml100"><a class="toc-item" href="/books/n/mlprobe/ml100/">uHTS for the identification of compounds that potentiate TRAIL-induced apoptosis of cancer cells</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml099"><a class="toc-item" href="/books/n/mlprobe/ml099/">Three small molecule pan activator families of Ras-related GTPases</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml096"><a class="toc-item" href="/books/n/mlprobe/ml096/">Therapeutic Inhibitors of Phosphomannose Isomerase - Probe 2</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml095"><a class="toc-item" href="/books/n/mlprobe/ml095/">Placental Alkaline Phosphatase (PLAP) Luminescent HTS assay - Probe 2</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml090"><a class="toc-item" href="/books/n/mlprobe/ml090/">Probe Report for NOX1 Inhibitors</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml089"><a class="toc-item" href="/books/n/mlprobe/ml089/">Therapeutic Inhibitors of Phosphomannose Isomerase - Probe 1</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml088"><a class="toc-item" href="/books/n/mlprobe/ml088/">HTS identification of compounds activating TNAP at an intermediate concentration of phosphate acceptor detected in luminescent assay</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml086"><a class="toc-item" href="/books/n/mlprobe/ml086/">The Role of PHOSPHO1 in the Initiation of Skeletal Calcification</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml085"><a class="toc-item" href="/books/n/mlprobe/ml085/">Placental Alkaline Phosphatase (PLAP) Luminescent HTS assay - Probe 1</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml084"><a class="toc-item" href="/books/n/mlprobe/ml084/">Identification of lipid storage modulators</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml083"><a class="toc-item" href="/books/n/mlprobe/ml083/">Identification of activators for the M2 isoform of human pyruvate kinase</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml081"><a class="toc-item" href="/books/n/mlprobe/ml081/">Probe Report for RBBP9 Inhibitors - Probe 1</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml080"><a class="toc-item" href="/books/n/mlprobe/ml080/">Probe Report for P97/cdc48 Inhibitors</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml079"><a class="toc-item" href="/books/n/mlprobe/ml079/">Identification of Functionally Selective Small Molecule Antagonists of the Neuropeptide-S Receptor: Naphthopyranopyrimidines</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml077"><a class="toc-item" href="/books/n/mlprobe/ml077/">Discovery of a Highly Selective KCC2 Antagonist</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml076"><a class="toc-item" href="/books/n/mlprobe/ml076/">Inhibitors of Protein Folding: DnaK</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml075"><a class="toc-item" href="/books/n/mlprobe/ml075/">Probe Report for NPY-Y2 Receptor Antagonists</a></li><li class="half_rhythm" id="toc_itm_NBK47352_toc_ml071"><a class="toc-item" href="/books/n/mlprobe/ml071/">Discovery of a Highly Selective <i>in vitro</i> and <i>in
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vivo</i> M1 Allosteric Agonist Probe</a></li></ul></li></ul></div></div></div>
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