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<meta name="ncbi_db" content="books" /><meta name="ncbi_pdid" content="book-part" /><meta name="ncbi_acc" content="NBK143563" /><meta name="ncbi_domain" content="mlprobe" /><meta name="ncbi_report" content="record" /><meta name="ncbi_type" content="fulltext" /><meta name="ncbi_objectid" content="" /><meta name="ncbi_pcid" content="/NBK143563/" /><meta name="ncbi_pagename" content="ML302, a Novel Beta-lactamase (BLA) Inhibitor - Probe Reports from the NIH Molecular Libraries Program - NCBI Bookshelf" /><meta name="ncbi_bookparttype" content="chapter" /><meta name="ncbi_app" content="bookshelf" />
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<title>ML302, a Novel Beta-lactamase (BLA) Inhibitor - Probe Reports from the NIH Molecular Libraries Program - NCBI Bookshelf</title>
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<meta name="robots" content="INDEX,FOLLOW,NOARCHIVE" /><meta name="citation_inbook_title" content="Probe Reports from the NIH Molecular Libraries Program [Internet]" /><meta name="citation_title" content="ML302, a Novel Beta-lactamase (BLA) Inhibitor" /><meta name="citation_publisher" content="National Center for Biotechnology Information (US)" /><meta name="citation_date" content="2014/05/13" /><meta name="citation_author" content="T Spicer" /><meta name="citation_author" content="D Minond" /><meta name="citation_author" content="I Enogieru" /><meta name="citation_author" content="SA Saldanha" /><meta name="citation_author" content="C Allais" /><meta name="citation_author" content="Qin Liu" /><meta name="citation_author" content="BA Mercer" /><meta name="citation_author" content="WR Roush" /><meta name="citation_author" content="P Hodder" /><meta name="citation_pmid" content="23762954" /><meta name="citation_fulltext_html_url" content="https://www.ncbi.nlm.nih.gov/books/NBK143563/" /><link rel="schema.DC" href="http://purl.org/DC/elements/1.0/" /><meta name="DC.Title" content="ML302, a Novel Beta-lactamase (BLA) Inhibitor" /><meta name="DC.Type" content="Text" /><meta name="DC.Publisher" content="National Center for Biotechnology Information (US)" /><meta name="DC.Contributor" content="T Spicer" /><meta name="DC.Contributor" content="D Minond" /><meta name="DC.Contributor" content="I Enogieru" /><meta name="DC.Contributor" content="SA Saldanha" /><meta name="DC.Contributor" content="C Allais" /><meta name="DC.Contributor" content="Qin Liu" /><meta name="DC.Contributor" content="BA Mercer" /><meta name="DC.Contributor" content="WR Roush" /><meta name="DC.Contributor" content="P Hodder" /><meta name="DC.Date" content="2014/05/13" /><meta name="DC.Identifier" content="https://www.ncbi.nlm.nih.gov/books/NBK143563/" /><meta name="description" content="VIM-2 and IMP-1 are Ambler class B metallo-β-lactamases (MBL) capable of hydrolyzing a broad-spectrum of β-lactam antibiotics. Although the discovery and development of MBL inhibitors continue to be an area of active research, an array of potent, non-selective (broad-acting) small molecule inhibitors is yet to be fully characterized. Here we describe a novel dual VIM-2/IMP-1 inhibitor that exhibits efficacy in multiple clinical isolates. We therefore claim CID 53362017/SID 134220672 as a potent, broad acting VIM-2/IMP-1 probe (ML302). This compound was discovered from a medicinal chemistry effort that sought to improve the potency and efficacy of high-throughput screening (HTS) hits. During these chemistry efforts, we identified a rhodanine scaffold that exhibited activity against recombinant VIM-2 and IMP-1 in nitrocefin-based enzyme activity assays. Various secondary assays were run to determine its dual potency (VIM-2 IC50 = 548 nM; IMP-1 IC50 = 3.02 μM) and class B selectivity (it was inactive in TEM-1 and AmpC beta-lactamase enzymatic assays). Kinetic analyses demonstrated that ML302 behaves as a mixed mode uncompetitive/non-competitive inhibitor, with submicromolar Ki values against VIM-2 and IMP-1 (Ki = 183 ± 24 nM and 930 ± 97 nM, respectively). This represents an improvement in both our prior probe ML121 and the previously existing art compound Mitoxantrone, each of which inhibited only VIM-2. Subsequent studies revealed that this probe potentiates the activity of imipenem antibiotic in inhibiting growth of laboratory E. coli BL21 strains harboring VIM-2 and IMP-1, as well as clinical isolates YMC07 (VIM-2-containing Acinetobacter sp.), BAA-2146 (NDM-1-containing Klebsiella pneumonia), PA641 (VIM-2-containing Pseudomonas aeruginosa), and KN20 (IMP-1-containing Pseudomonas aeruginosa). This probe will serve as a valuable tool to elucidate the role of VIM-2 and IMP-1 in nosocomial beta-lactam antibiotic resistance." /><meta name="og:title" content="ML302, a Novel Beta-lactamase (BLA) Inhibitor" /><meta name="og:type" content="book" /><meta name="og:description" content="VIM-2 and IMP-1 are Ambler class B metallo-β-lactamases (MBL) capable of hydrolyzing a broad-spectrum of β-lactam antibiotics. Although the discovery and development of MBL inhibitors continue to be an area of active research, an array of potent, non-selective (broad-acting) small molecule inhibitors is yet to be fully characterized. Here we describe a novel dual VIM-2/IMP-1 inhibitor that exhibits efficacy in multiple clinical isolates. We therefore claim CID 53362017/SID 134220672 as a potent, broad acting VIM-2/IMP-1 probe (ML302). This compound was discovered from a medicinal chemistry effort that sought to improve the potency and efficacy of high-throughput screening (HTS) hits. During these chemistry efforts, we identified a rhodanine scaffold that exhibited activity against recombinant VIM-2 and IMP-1 in nitrocefin-based enzyme activity assays. Various secondary assays were run to determine its dual potency (VIM-2 IC50 = 548 nM; IMP-1 IC50 = 3.02 μM) and class B selectivity (it was inactive in TEM-1 and AmpC beta-lactamase enzymatic assays). Kinetic analyses demonstrated that ML302 behaves as a mixed mode uncompetitive/non-competitive inhibitor, with submicromolar Ki values against VIM-2 and IMP-1 (Ki = 183 ± 24 nM and 930 ± 97 nM, respectively). This represents an improvement in both our prior probe ML121 and the previously existing art compound Mitoxantrone, each of which inhibited only VIM-2. Subsequent studies revealed that this probe potentiates the activity of imipenem antibiotic in inhibiting growth of laboratory E. coli BL21 strains harboring VIM-2 and IMP-1, as well as clinical isolates YMC07 (VIM-2-containing Acinetobacter sp.), BAA-2146 (NDM-1-containing Klebsiella pneumonia), PA641 (VIM-2-containing Pseudomonas aeruginosa), and KN20 (IMP-1-containing Pseudomonas aeruginosa). This probe will serve as a valuable tool to elucidate the role of VIM-2 and IMP-1 in nosocomial beta-lactam antibiotic resistance." /><meta name="og:url" content="https://www.ncbi.nlm.nih.gov/books/NBK143563/" /><meta name="og:site_name" content="NCBI Bookshelf" /><meta name="og:image" content="https://www.ncbi.nlm.nih.gov/corehtml/pmc/pmcgifs/bookshelf/thumbs/th-mlprobe-lrg.png" /><meta name="twitter:card" content="summary" /><meta name="twitter:site" content="@ncbibooks" /><meta name="bk-non-canon-loc" content="/books/n/mlprobe/ml302/" /><link rel="canonical" href="https://www.ncbi.nlm.nih.gov/books/NBK143563/" /><link rel="stylesheet" href="/corehtml/pmc/css/figpopup.css" type="text/css" media="screen" /><link rel="stylesheet" href="/corehtml/pmc/css/bookshelf/2.26/css/books.min.css" type="text/css" /><link rel="stylesheet" href="/corehtml/pmc/css/bookshelf/2.26/css/books_print.min.css" type="text/css" media="print" /><style type="text/css">p a.figpopup{display:inline !important} .bk_tt {font-family: monospace} .first-line-outdent .bk_ref {display: inline} .body-content h2, .body-content .h2 {border-bottom: 1px solid #97B0C8} .body-content h2.inline {border-bottom: none} a.page-toc-label , .jig-ncbismoothscroll a {text-decoration:none;border:0 !important} .temp-labeled-list .graphic {display:inline-block !important} .temp-labeled-list img{width:100%}</style><script type="text/javascript" src="/corehtml/pmc/js/jquery.hoverIntent.min.js"> </script><script type="text/javascript" src="/corehtml/pmc/js/common.min.js?_=3.18"> </script><script type="text/javascript" src="/corehtml/pmc/js/large-obj-scrollbars.min.js"> </script><script type="text/javascript">window.name="mainwindow";</script><script type="text/javascript" src="/corehtml/pmc/js/bookshelf/2.26/book-toc.min.js"> </script><script type="text/javascript" src="/corehtml/pmc/js/bookshelf/2.26/books.min.js"> </script><meta name="book-collection" content="NONE" />
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<div class="pre-content"><div><div class="bk_prnt"><p class="small">NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.</p><p>Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-. </p></div><div class="iconblock clearfix whole_rhythm no_top_margin bk_noprnt"><a class="img_link icnblk_img" title="Table of Contents Page" href="/books/n/mlprobe/"><img class="source-thumb" src="/corehtml/pmc/pmcgifs/bookshelf/thumbs/th-mlprobe-lrg.png" alt="Cover of Probe Reports from the NIH Molecular Libraries Program" height="100px" width="80px" /></a><div class="icnblk_cntnt eight_col"><h2>Probe Reports from the NIH Molecular Libraries Program [Internet].</h2><a data-jig="ncbitoggler" href="#__NBK143563_dtls__">Show details</a><div style="display:none" class="ui-widget" id="__NBK143563_dtls__"><div>Bethesda (MD): National Center for Biotechnology Information (US); 2010-.</div></div><div class="half_rhythm"><ul class="inline_list"><li style="margin-right:1em"><a class="bk_cntns" href="/books/n/mlprobe/">Contents</a></li></ul></div><div class="bk_noprnt"><form method="get" action="/books/n/mlprobe/" id="bk_srch"><div class="bk_search"><label for="bk_term" class="offscreen_noflow">Search term</label><input type="text" title="Search this book" id="bk_term" name="term" value="" data-jig="ncbiclearbutton" /> <input type="submit" class="jig-ncbibutton" value="Search this book" submit="false" style="padding: 0.1em 0.4em;" /></div></form></div></div><div class="icnblk_cntnt two_col"><div class="pagination bk_noprnt"><a class="active page_link prev" href="/books/n/mlprobe/ml303/" title="Previous page in this title">< Prev</a><a class="active page_link next" href="/books/n/mlprobe/ml300/" title="Next page in this title">Next ></a></div></div></div></div></div>
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<div class="main-content lit-style" itemscope="itemscope" itemtype="http://schema.org/CreativeWork"><div class="meta-content fm-sec"><h1 id="_NBK143563_"><span class="title" itemprop="name">ML302, a Novel Beta-lactamase (BLA) Inhibitor</span></h1><p class="contrib-group"><span itemprop="author">T Spicer</span>, <span itemprop="author">D Minond</span>, <span itemprop="author">I Enogieru</span>, <span itemprop="author">SA Saldanha</span>, <span itemprop="author">C Allais</span>, <span itemprop="author">Qin Liu</span>, <span itemprop="author">BA Mercer</span>, <span itemprop="author">WR Roush</span>, and <span itemprop="author">P Hodder</span>.</p><a data-jig="ncbitoggler" href="#__NBK143563_ai__" style="border:0;text-decoration:none">Author Information and Affiliations</a><div style="display:none" class="ui-widget" id="__NBK143563_ai__"><p class="contrib-group"><h4>Authors</h4><span itemprop="author">T Spicer</span>,<sup>1</sup> <span itemprop="author">D Minond</span>,<sup>1</sup> <span itemprop="author">I Enogieru</span>,<sup>1</sup> <span itemprop="author">SA Saldanha</span>,<sup>1</sup> <span itemprop="author">C Allais</span>,<sup>2</sup> <span itemprop="author">Qin Liu</span>,<sup>2</sup> <span itemprop="author">BA Mercer</span>,<sup>1</sup> <span itemprop="author">WR Roush</span>,<sup>2</sup> and <span itemprop="author">P Hodder</span><sup>1</sup><sup>,3</sup>.</p><h4>Affiliations</h4><div class="affiliation"><sup>1</sup>
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Lead Identification Division, Translational Research Institute, Scripps Florida, 130 Scripps Way, Jupiter, Fl, 33458</div><div class="affiliation"><sup>2</sup>
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Department of Chemistry, Scripps Florida, 130 Scripps Way, Jupiter, Fl, 33458</div><div class="affiliation">
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<sup>3</sup> To whom correspondence should be addressed,
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<span class="before-email-separator"></span><span class="email-label">Email: </span><a href="mailto:dev@null" data-email="ude.sppircs@preddoh" class="oemail">ude.sppircs@preddoh</a></div></div><p class="small">Received: <span itemprop="datePublished">April 16, 2012</span>; Last Update: <span itemprop="dateModified">May 13, 2014</span>.</p></div><div class="jig-ncbiinpagenav body-content whole_rhythm" data-jigconfig="allHeadingLevels: ['h2'],smoothScroll: false" itemprop="text"><div id="_abs_rndgid_" itemprop="description"><p>VIM-2 and IMP-1 are Ambler class B metallo-β-lactamases (MBL) capable of hydrolyzing a broad-spectrum of β-lactam antibiotics. Although the discovery and development of MBL inhibitors continue to be an area of active research, an array of potent, non-selective (broad-acting) small molecule inhibitors is yet to be fully characterized. Here we describe a novel dual VIM-2/IMP-1 inhibitor that exhibits efficacy in multiple clinical isolates. We therefore claim CID 53362017/<a href="https://pubchem.ncbi.nlm.nih.gov/substance/134220672" ref="pagearea=abstract&targetsite=entrez&targetcat=link&targettype=pubchem">SID 134220672</a> as a potent, broad acting VIM-2/IMP-1 probe (<a href="/pcsubstance/?term=ML302[synonym]" ref="pagearea=abstract&targetsite=entrez&targetcat=term&targettype=pubchem">ML302</a>). This compound was discovered from a medicinal chemistry effort that sought to improve the potency and efficacy of high-throughput screening (HTS) hits. During these chemistry efforts, we identified a rhodanine scaffold that exhibited activity against recombinant VIM-2 and IMP-1 in nitrocefin-based enzyme activity assays. Various secondary assays were run to determine its dual potency (VIM-2 IC<sub>50</sub> = 548 nM; IMP-1 IC<sub>50</sub> = 3.02 μM) and class B selectivity (it was inactive in TEM-1 and AmpC beta-lactamase enzymatic assays). Kinetic analyses demonstrated that <a href="/pcsubstance/?term=ML302[synonym]" ref="pagearea=abstract&targetsite=entrez&targetcat=term&targettype=pubchem">ML302</a> behaves as a mixed mode uncompetitive/non-competitive inhibitor, with submicromolar K<sub>i</sub> values against VIM-2 and IMP-1 (K<sub>i</sub> = 183 ± 24 nM and 930 ± 97 nM, respectively). This represents an improvement in both our prior probe <a href="/pcsubstance/?term=ML121[synonym]" ref="pagearea=abstract&targetsite=entrez&targetcat=term&targettype=pubchem">ML121</a> and the previously existing art compound Mitoxantrone, each of which inhibited only VIM-2. Subsequent studies revealed that this probe potentiates the activity of imipenem antibiotic in inhibiting growth of laboratory <i>E. coli</i> BL21 strains harboring VIM-2 and IMP-1, as well as clinical isolates YMC07 (VIM-2-containing <i>Acinetobacter</i> sp.), BAA-2146 (NDM-1-containing <i>Klebsiella pneumonia</i>), PA641 (VIM-2-containing <i>Pseudomonas aeruginosa</i>), and KN20 (IMP-1-containing <i>Pseudomonas aeruginosa</i>). This probe will serve as a valuable tool to elucidate the role of VIM-2 and IMP-1 in nosocomial beta-lactam antibiotic resistance.</p></div><div class="h2"></div><p><b>Assigned Assay Grant #:</b> 1 R21 NS059451-01 Fast Track</p><p><b>Screening Center Name & PI:</b> Scripps Research Institute Molecular Screening Center (SRIMSC); Hugh Rosen</p><p><b>Chemistry Center Name & PI:</b> SRIMSC; Hugh Rosen</p><p><b>Assay Submitter & Institution:</b> Peter Hodder, TSRI</p><p><b>PubChem Summary Bioassay Identifier (AID):</b>
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<a href="https://pubchem.ncbi.nlm.nih.gov/bioassay/1854" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">1854</a></p><div id="ml302.s1"><h2 id="_ml302_s1_">Probe Structure and Characteristics</h2><div id="ml302.fu1" class="figure bk_fig"><div class="graphic"><img src="/books/NBK143563/bin/ml302fu1.jpg" alt="DUAL VIM-2/IMP-1 Inhibitor Probe ML302." /></div><h3><span class="title">DUAL VIM-2/IMP-1 Inhibitor Probe ML302</span></h3><div class="caption"><p>CID 53362017/<a href="https://pubchem.ncbi.nlm.nih.gov/substance/134220672" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">SID 134220672</a></p><p>MLS003940491 (SR-030000025555)</p></div></div><div id="ml302.tu1" class="table"><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK143563/table/ml302.tu1/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ml302.tu1_lrgtbl__"><table><thead><tr><th id="hd_h_ml302.tu1_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">CID/ML#</th><th id="hd_h_ml302.tu1_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Target Name</th><th id="hd_h_ml302.tu1_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">IC50 (nM) [SID, AID]</th><th id="hd_h_ml302.tu1_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Anti-target Name</th><th id="hd_h_ml302.tu1_1_1_1_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">IC<sub>50</sub> (μM) [SID, AID]</th><th id="hd_h_ml302.tu1_1_1_1_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Fold Selective</th><th id="hd_h_ml302.tu1_1_1_1_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Secondary Assays: IC50 (nM) [SID, AID]</th></tr></thead><tbody><tr><td headers="hd_h_ml302.tu1_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><b>CID 53362017/<a href="/pcsubstance/?term=ML302[synonym]" ref="pagearea=body&targetsite=entrez&targetcat=term&targettype=pubchem">ML302</a></b></td><td headers="hd_h_ml302.tu1_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><b>VIM-2</b></td><td headers="hd_h_ml302.tu1_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><u><b>Enzyme Assays:</b></u><br /><br />IC<sub>50</sub> = 548 nM [<a href="https://pubchem.ncbi.nlm.nih.gov/substance/125264855" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">SID 125264855</a>, <a href="https://pubchem.ncbi.nlm.nih.gov/bioassay/624079" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">AID 624079</a><br /><br />K<sub>i</sub> = 183 nM [<a href="https://pubchem.ncbi.nlm.nih.gov/substance/134220672" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">SID134220672</a>, <a href="https://pubchem.ncbi.nlm.nih.gov/bioassay/624083" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">AID 624083</a>]</td><td headers="hd_h_ml302.tu1_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><b>IMP-1</b></td><td headers="hd_h_ml302.tu1_1_1_1_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><u><b>Enzyme Assays</b>:</u><br /><br />IC<sub>50</sub> = 3.018 μM [<a href="https://pubchem.ncbi.nlm.nih.gov/substance/125264855" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">SID 125264855</a>, <a href="https://pubchem.ncbi.nlm.nih.gov/bioassay/624085" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">AID 624085</a>]<br /><br />K<sub>i</sub> = 930 nM [<a href="https://pubchem.ncbi.nlm.nih.gov/substance/134220672" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">SID134220672</a>, <a href="https://pubchem.ncbi.nlm.nih.gov/bioassay/624084" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">AID 624084</a>]</td><td headers="hd_h_ml302.tu1_1_1_1_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">>5.5</td><td headers="hd_h_ml302.tu1_1_1_1_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><u><b>Enzyme counterscreens:</b></u><br /><br /><b>TEM-1</b> IC<sub>50</sub> >60 μM [<a href="https://pubchem.ncbi.nlm.nih.gov/substance/125264855" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">SID125264855</a>, <a href="https://pubchem.ncbi.nlm.nih.gov/bioassay/624092" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">AID 624092</a>]<br /><b>AmpC</b> IC<sub>50</sub> >60 μM [<a href="https://pubchem.ncbi.nlm.nih.gov/substance/125264855" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">SID125264855</a>, <a href="https://pubchem.ncbi.nlm.nih.gov/bioassay/624090" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">AID 624090</a>]<br /><br /><u><b>Imipenem Synergy assays:</b></u><br /><i>measured as a reduction (potentiation) of the MIC of imipenem in the following bacterial strains:</i><br /><br /><b>YMC07/8/B3323 (VIM-2)</b><br />Achieves 32X Potentiation at 781 nM [<a href="https://pubchem.ncbi.nlm.nih.gov/substance/125264855" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">SID 125264855</a>, <a href="https://pubchem.ncbi.nlm.nih.gov/bioassay/624097" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">AID 624097</a>]<br /><b>BL21 (VIM-2)</b><br />Achieves 8X Potentiation at 3.125 μM [<a href="https://pubchem.ncbi.nlm.nih.gov/substance/125264855" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">SID 125264855</a>, <a href="https://pubchem.ncbi.nlm.nih.gov/bioassay/624081" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">AID 624081</a>]<br /><b>PA641 (VIM-2)</b><br />Achieves 4X Potentiation at 50 μM [<a href="https://pubchem.ncbi.nlm.nih.gov/substance/125264855" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">SID 125264855</a>, <a href="https://pubchem.ncbi.nlm.nih.gov/bioassay/624080" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">AID 624080</a>]<br /><b>BAA-2146 (NDM-1)</b><br />Achieves 2X Potentiation at >50 μM [<a href="https://pubchem.ncbi.nlm.nih.gov/substance/125264855" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">SID 125264855</a>, <a href="https://pubchem.ncbi.nlm.nih.gov/bioassay/624082" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">AID 624082</a>]<br /><b>KN20 (IMP-1)</b><br />Achieves 2X Potentiation at >50 μM [<a href="https://pubchem.ncbi.nlm.nih.gov/substance/125264855" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">SID 125264855</a>, <a href="https://pubchem.ncbi.nlm.nih.gov/bioassay/624095" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">AID 624095</a>]<br /><b>BL21 (IMP-1)</b><br />Achieves 4X Potentiation at 781 nM [<a href="https://pubchem.ncbi.nlm.nih.gov/substance/125264855" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">SID 125264855</a>, <a href="https://pubchem.ncbi.nlm.nih.gov/bioassay/624097" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">AID 624097</a>]</td></tr></tbody></table></div></div></div><div id="ml302.s2"><h2 id="_ml302_s2_">Recommendations for scientific use of the probe</h2><p><i>Limitations in state of the art.</i> We previously submitted a probe report describing a selective VIM-2 inhibitor (<a href="/pcsubstance/?term=ML121[synonym]" ref="pagearea=body&targetsite=entrez&targetcat=term&targettype=pubchem">ML121</a>). This probe was potent and active against the VIM-2 target. However, it lacked activity against the IMP-1 enzyme, which might limit its usefulness in clinically resistant bacterial strains that may express more than one β-lactamase. Another non-competitive VIM-2 inhibitor, mitoxantrone (1,4-dihydroxy-5,8-bis([2-([2-hydroxyethyl]amino)ethyl]amino)-9,10-anthracenedione; CID 4212), is a type II topoisomerase inhibitor that disrupts DNA synthesis and DNA repair in both healthy cells and cancer cells [<a class="bk_pop" href="#ml302.r1">1</a>]. Like <a href="/pcsubstance/?term=ML121[synonym]" ref="pagearea=body&targetsite=entrez&targetcat=term&targettype=pubchem">ML121</a>, its inhibition is also selective to VIM-2 and its intense color limits Mitoxantrone’s use in certain assay detection formats. Another prior art compound, 4-chloromercuribenzoic acid (<i>p</i>CMB; CID 1730), is a slowly reversible/irreversible VIM-2 inhibitor shown to have a synergistic effect with β-lactam antibacterials in VIM-2-expressing bacteria.[<a class="bk_pop" href="#ml302.r2">2</a>] Unfortunately, this cysteine-reactive reagent is known to have several off-target activities, lessening its value for mechanistic studies.</p><p><i>Probe Applications.</i> Here we demonstrate that our probe <a href="/pcsubstance/?term=ML302[synonym]" ref="pagearea=body&targetsite=entrez&targetcat=term&targettype=pubchem">ML302</a> (CID 53362017/<a href="https://pubchem.ncbi.nlm.nih.gov/substance/134220672" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">SID 134220672</a>/SR-03000002555) blocks the enzymatic activities of VIM-2 and IMP-1 in biochemical assays, with no apparent activity against class A (TEM-1) and class C (AmpC) b-lactamases. When dosed in clinical isolates, <a href="/pcsubstance/?term=ML302[synonym]" ref="pagearea=body&targetsite=entrez&targetcat=term&targettype=pubchem">ML302</a> shows no toxicity; when co-dosed with imipenem, <a href="/pcsubstance/?term=ML302[synonym]" ref="pagearea=body&targetsite=entrez&targetcat=term&targettype=pubchem">ML302</a> significantly increases imipenem’s efficacy (MIC). These findings have significant implications for studies that probe the enzymology of VIM-2 and IMP-1, especially mechanistic studies to better understand these enzymes’ broad-spectrum activity against various beta-lactam based antibiotics. Further, this probe can be useful for experiments that aim to inhibit VIM-2 and IMP-1 activity, without inhibiting TEM-1 or AmpC activity. In a broader role, the non-selectivity, potency, and efficacy of this compound will enable further investigations into the biological and biochemical roles of metallo-β-lactamase enzymes, and may be useful in the design of inhibitors to inhibit these clinically relevant enzymes and reduce the public health burden of antibiotic resistance.</p><p><i>Expected end-users of the probe in the research community</i>. The probe can be used by researchers studying microbiology, antibiotic chemistry, β-lactamase enzymology. Thus, it is conceivable that scientists in diverse fields will be able to apply <a href="/pcsubstance/?term=ML302[synonym]" ref="pagearea=body&targetsite=entrez&targetcat=term&targettype=pubchem">ML302</a> to elucidate the role of VIM-2 and IMP-1 in bacterial resistance pathways and investigate mechanisms of VIM-2 and IMP-1 inhibition in biochemical and microbiology-based assays.</p><p><i>Relevant biology of the probe.</i> VIM-2 and IMP-1 are a zinc-dependent, Ambler Class “B” β-lactamases that hydrolyze β-lactam based antibiotics (e.g. penicillins, carbapenems), rendering them ineffective. No VIM-2 inhibitors yet exist for clinical use, and all VIM-2 inhibitors reported to date have been designed to bind zinc or modify cysteine found in the enzyme’s active site. Further, no dual-acting inhibitors exist which block activity of both of these enzymes. Therefore, selective, non-competitive VIM-2 inhibitors are desired to probe VIM-2 function exclusive of active site inhibition.</p></div><div id="ml302.s3"><h2 id="_ml302_s3_">1. Introduction</h2><p>The emergence of Gram-negative bacteria that exhibit multi-drug resistance, combined with the lack of new antibiotics, poses a public health challenge [<a class="bk_pop" href="#ml302.r3">3</a>]. The production of bacterial β-lactamase enzymes, in particular, is a common mechanism of drug resistance [<a class="bk_pop" href="#ml302.r4">4</a>–<a class="bk_pop" href="#ml302.r6">6</a>]. The β-lactamases evolved from bacteria with resistance to naturally-occurring β-lactams or penams [<a class="bk_pop" href="#ml302.r7">7</a>], agents which inhibit the transpeptidase involved in cell wall biosynthesis [<a class="bk_pop" href="#ml302.r8">8</a>]. Human medicine adapted these agents into synthetic antibiotics such as penicillins, cephalosporins, carbapenems, and monobactams that contain a 2-azetidone ring [<a class="bk_pop" href="#ml302.r7">7</a>, <a class="bk_pop" href="#ml302.r9">9</a>]. The metallo-β-lactamases (MBL) are zinc-dependent class B β-lactamases that hydrolyze the β-lactam ring, rendering the antibiotic ineffective [<a class="bk_pop" href="#ml302.r8">8</a>, <a class="bk_pop" href="#ml302.r10">10</a>]. Increasingly, nosocomial beta-lactam antibiotic resistance arises in <i>P. aeruginosa</i>, <i>Enterobacteriaceae</i>, and other pathogenic bacteria via gene transfer of B1 MBLs [<a class="bk_pop" href="#ml302.r6">6</a>, <a class="bk_pop" href="#ml302.r11">11</a>], including IMP (active on IMiPenem) [<a class="bk_pop" href="#ml302.r12">12</a>] and VIM (Verona IMipenemase) [<a class="bk_pop" href="#ml302.r13">13</a>, <a class="bk_pop" href="#ml302.r14">14</a>]. For two of these enzymes, VIM-2 and IMP-1, no inhibitors exist for clinical use [<a class="bk_pop" href="#ml302.r8">8</a>, <a class="bk_pop" href="#ml302.r11">11</a>]. Thus, the identification of MBL inhibitors would provide useful tools for reducing nosocomial infections and elucidating their mechanism of action [<a class="bk_pop" href="#ml302.r2">2</a>, <a class="bk_pop" href="#ml302.r15">15</a>]. In the present report, we identify and characterize a compound belonging to a novel rhodanine scaffold that inhibits both VIM-2 and IMP-1 with submicromolar K<sub>i</sub> values. This represents a significant advance in the field of broad acting β-lactamase inhibitors.</p></div><div id="ml302.s4"><h2 id="_ml302_s4_">2. Materials and Methods</h2><div id="ml302.s5"><h3>2.1. Assays</h3><div id="ml302.t1" class="table"><h3><span class="label">Table 1</span><span class="title">Assays from the HTS campaign and prior probe discovery effort (ML121)</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK143563/table/ml302.t1/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ml302.t1_lrgtbl__"><table class="no_top_margin"><thead><tr><th id="hd_h_ml302.t1_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">AID</th><th id="hd_h_ml302.t1_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Assay Name</th><th id="hd_h_ml302.t1_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Assay Type</th><th id="hd_h_ml302.t1_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Target</th><th id="hd_h_ml302.t1_1_1_1_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Powder Sample</th></tr></thead><tbody><tr><td headers="hd_h_ml302.t1_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/bioassay/1527" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">1527</a></td><td headers="hd_h_ml302.t1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Primary biochemical HTS assay to identify inhibitors of VIM-2.</td><td headers="hd_h_ml302.t1_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Primary Assay (1X%INH)</td><td headers="hd_h_ml302.t1_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">VIM-2</td><td headers="hd_h_ml302.t1_1_1_1_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">No</td></tr><tr><td headers="hd_h_ml302.t1_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/bioassay/1556" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">1556</a></td><td headers="hd_h_ml302.t1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Epi-absorbance primary biochemical HTS assay to identify inhibitors of IMP-1 metallo-beta-lactamase.</td><td headers="hd_h_ml302.t1_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Primary Assay (1X%INH)</td><td headers="hd_h_ml302.t1_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">IMP-1</td><td headers="hd_h_ml302.t1_1_1_1_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">No</td></tr><tr><td headers="hd_h_ml302.t1_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/bioassay/1856" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">1856</a></td><td headers="hd_h_ml302.t1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Epi-absorbance-based counterscreen for selective VIM-2 inhibitors: biochemical HTS assay to identify inhibitors of IMP-1 metallo-beta-lactamase.</td><td headers="hd_h_ml302.t1_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Counterscreen (3X%INH)</td><td headers="hd_h_ml302.t1_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">IMP-1</td><td headers="hd_h_ml302.t1_1_1_1_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">No</td></tr><tr><td headers="hd_h_ml302.t1_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/bioassay/1857" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">1857</a></td><td headers="hd_h_ml302.t1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">FRET-based counterscreen assay for selective VIM-2 inhibitors: biochemical HTS assay to identify epi-absorbance assay artifacts.</td><td headers="hd_h_ml302.t1_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Counterscreen (3X%INH)</td><td headers="hd_h_ml302.t1_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">VIM-2 (CCF2)</td><td headers="hd_h_ml302.t1_1_1_1_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">No</td></tr><tr><td headers="hd_h_ml302.t1_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/bioassay/1860" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">1860</a></td><td headers="hd_h_ml302.t1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Epi-absorbance-based confirmation biochemical HTS assay to identify selective inhibitors of VIM-2 metallo-beta-lactamase.</td><td headers="hd_h_ml302.t1_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Confirmation (3X %INH)</td><td headers="hd_h_ml302.t1_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">VIM-2</td><td headers="hd_h_ml302.t1_1_1_1_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">No</td></tr><tr><td headers="hd_h_ml302.t1_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/bioassay/1866" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">1866</a></td><td headers="hd_h_ml302.t1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Epi-absorbance-based counterscreen assay for selective VIM-2 inhibitors: biochemical HTS assay to identify inhibitors of TEM-1 serine-beta-lactamase.</td><td headers="hd_h_ml302.t1_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Counterscreen (3X%INH)</td><td headers="hd_h_ml302.t1_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">TEM-1</td><td headers="hd_h_ml302.t1_1_1_1_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">No</td></tr><tr><td headers="hd_h_ml302.t1_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/bioassay/1919" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">1919</a></td><td headers="hd_h_ml302.t1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Epi-absorbance-based dose response biochemical high throughput screening assay for selective inhibitors of VIM-2 metallo-beta-lactamase.</td><td headers="hd_h_ml302.t1_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Dose Response (3X IC50)</td><td headers="hd_h_ml302.t1_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">VIM-2</td><td headers="hd_h_ml302.t1_1_1_1_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">No</td></tr><tr><td headers="hd_h_ml302.t1_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/bioassay/1920" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">1920</a></td><td headers="hd_h_ml302.t1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Epi-absorbance-based counterscreen for selective VIM-2 inhibitors: dose response biochemical high throughput screening assay to identify inhibitors of IMP-1 metallo-beta-lactamase.</td><td headers="hd_h_ml302.t1_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Dose Response Counterscreen (3X IC50)</td><td headers="hd_h_ml302.t1_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">IMP-1</td><td headers="hd_h_ml302.t1_1_1_1_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">No</td></tr><tr><td headers="hd_h_ml302.t1_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/bioassay/1925" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">1925</a></td><td headers="hd_h_ml302.t1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Epi-absorbance-based counterscreen for selective VIM-2 inhibitors: dose response biochemical high throughput screening assay to identify inhibitors of TEM-1 serine-beta-lactamase.</td><td headers="hd_h_ml302.t1_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Dose Response Counterscreen (3X IC50)</td><td headers="hd_h_ml302.t1_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">TEM-1</td><td headers="hd_h_ml302.t1_1_1_1_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">No</td></tr><tr><td headers="hd_h_ml302.t1_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/bioassay/1926" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">1926</a></td><td headers="hd_h_ml302.t1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">FRET-based counterscreen for selective VIM-2 inhibitors: dose response biochemical high throughput screening assay to identify epi-absorbance assay artifacts.</td><td headers="hd_h_ml302.t1_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Dose Response Counterscreen (3X IC50)</td><td headers="hd_h_ml302.t1_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">VIM-2 (CCF2)</td><td headers="hd_h_ml302.t1_1_1_1_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">No</td></tr><tr><td headers="hd_h_ml302.t1_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/bioassay/1927" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">1927</a></td><td headers="hd_h_ml302.t1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">FRET-based counterscreen for selective VIM-2 inhibitors: dose response biochemical high throughput screening assay to identify inhibitors of IMP-1 metallo-beta-lactamase.</td><td headers="hd_h_ml302.t1_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Dose Response Counterscreen (3X IC50)</td><td headers="hd_h_ml302.t1_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">IMP-1 (CCF2)</td><td headers="hd_h_ml302.t1_1_1_1_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">No</td></tr><tr><td headers="hd_h_ml302.t1_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/bioassay/1854" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">1854</a></td><td headers="hd_h_ml302.t1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Summary of probe development efforts to identify selective inhibitors of VIM-2 metallo-beta-lactamase.</td><td headers="hd_h_ml302.t1_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Summary</td><td headers="hd_h_ml302.t1_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">VIM-2</td><td headers="hd_h_ml302.t1_1_1_1_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">No</td></tr><tr><td headers="hd_h_ml302.t1_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/bioassay/2128" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">2128</a></td><td headers="hd_h_ml302.t1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Late stage results from the probe development efforts to identify inhibitors of VIM-2: probe results</td><td headers="hd_h_ml302.t1_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Late Stage AID (probe)</td><td headers="hd_h_ml302.t1_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">VIM-2</td><td headers="hd_h_ml302.t1_1_1_1_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Yes</td></tr><tr><td headers="hd_h_ml302.t1_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/bioassay/2317" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">2317</a></td><td headers="hd_h_ml302.t1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Late stage results from the probe development efforts to identify selective inhibitors of VIM-2 metallo-beta-lactamase: Prior art results.</td><td headers="hd_h_ml302.t1_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Late Stage AID (prior art)</td><td headers="hd_h_ml302.t1_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">VIM-2</td><td headers="hd_h_ml302.t1_1_1_1_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Yes</td></tr><tr><td headers="hd_h_ml302.t1_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/bioassay/504620" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">504620</a></td><td headers="hd_h_ml302.t1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Late stage Assay provider assay to determine imipenem Synergy of probe <a href="/pcsubstance/?term=ML121[synonym]" ref="pagearea=body&targetsite=entrez&targetcat=term&targettype=pubchem">ML121</a></td><td headers="hd_h_ml302.t1_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Late Stage AID (probe <a href="/pcsubstance/?term=ML121[synonym]" ref="pagearea=body&targetsite=entrez&targetcat=term&targettype=pubchem">ML121</a>)</td><td headers="hd_h_ml302.t1_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">VIM-2</td><td headers="hd_h_ml302.t1_1_1_1_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Yes</td></tr></tbody></table></div></div><div id="ml302.t2" class="table"><h3><span class="label">Table 2</span><span class="title">Assays for the current probe discovery effort (ML302)</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK143563/table/ml302.t2/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ml302.t2_lrgtbl__"><table class="no_top_margin"><thead><tr><th id="hd_h_ml302.t2_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">AID</th><th id="hd_h_ml302.t2_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Assay Name</th><th id="hd_h_ml302.t2_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Assay Type</th><th id="hd_h_ml302.t2_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Target</th><th id="hd_h_ml302.t2_1_1_1_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Powder Sample</th></tr></thead><tbody><tr><td headers="hd_h_ml302.t2_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/bioassay/624079" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">624079</a></td><td headers="hd_h_ml302.t2_1_1_1_2" rowspan="4" colspan="1" style="text-align:left;vertical-align:middle;">Absorbance-based Biochemical Nitrocefin Substrate Hydrolysis Assays (IC50)</td><td headers="hd_h_ml302.t2_1_1_1_3" rowspan="4" colspan="1" style="text-align:center;vertical-align:middle;">Dose Response (2X IC<sub>50</sub>) (probe <a href="/pcsubstance/?term=ML302[synonym]" ref="pagearea=body&targetsite=entrez&targetcat=term&targettype=pubchem">ML302</a>)</td><td headers="hd_h_ml302.t2_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">VIM-2</td><td headers="hd_h_ml302.t2_1_1_1_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Yes</td></tr><tr><td headers="hd_h_ml302.t2_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/bioassay/624085" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">624085</a></td><td headers="hd_h_ml302.t2_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">IMP-1</td><td headers="hd_h_ml302.t2_1_1_1_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Yes</td></tr><tr><td headers="hd_h_ml302.t2_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/bioassay/624092" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">624092</a></td><td headers="hd_h_ml302.t2_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">TEM-1</td><td headers="hd_h_ml302.t2_1_1_1_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Yes</td></tr><tr><td headers="hd_h_ml302.t2_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/bioassay/624090" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">624090</a></td><td headers="hd_h_ml302.t2_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">AmpC</td><td headers="hd_h_ml302.t2_1_1_1_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Yes</td></tr><tr><td headers="hd_h_ml302.t2_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/bioassay/624083" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">624083</a></td><td headers="hd_h_ml302.t2_1_1_1_2" rowspan="2" colspan="1" style="text-align:left;vertical-align:middle;">Absorbance-based Biochemical Nitrocefin Substrate Hydrolysis Assays (Ki and Km)</td><td headers="hd_h_ml302.t2_1_1_1_3" rowspan="2" colspan="1" style="text-align:center;vertical-align:middle;">Dose Response (2X)</td><td headers="hd_h_ml302.t2_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">VIM-2</td><td headers="hd_h_ml302.t2_1_1_1_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Yes</td></tr><tr><td headers="hd_h_ml302.t2_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/bioassay/624084" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">624084</a></td><td headers="hd_h_ml302.t2_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">IMP-1</td><td headers="hd_h_ml302.t2_1_1_1_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Yes</td></tr><tr><td headers="hd_h_ml302.t2_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/bioassay/624096" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">624096</a></td><td headers="hd_h_ml302.t2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Absorbance based Imipenem Antibiotic Synergy Assay (MIC4X): YMC07/B3323</td><td headers="hd_h_ml302.t2_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Dose Response (2X)</td><td headers="hd_h_ml302.t2_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">VIM-2</td><td headers="hd_h_ml302.t2_1_1_1_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Yes</td></tr><tr><td headers="hd_h_ml302.t2_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/bioassay/624081" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">624081</a></td><td headers="hd_h_ml302.t2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Absorbance based Imipenem Antibiotic Synergy Assay (MIC4X): BL21</td><td headers="hd_h_ml302.t2_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Dose Response (2X)</td><td headers="hd_h_ml302.t2_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">VIM-2</td><td headers="hd_h_ml302.t2_1_1_1_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Yes</td></tr><tr><td headers="hd_h_ml302.t2_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/bioassay/624080" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">624080</a></td><td headers="hd_h_ml302.t2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Absorbance based Imipenem Antibiotic Synergy Assay (MIC4X): PA641</td><td headers="hd_h_ml302.t2_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Dose Response (2X)</td><td headers="hd_h_ml302.t2_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">VIM-2</td><td headers="hd_h_ml302.t2_1_1_1_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Yes</td></tr><tr><td headers="hd_h_ml302.t2_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/bioassay/624082" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">624082</a></td><td headers="hd_h_ml302.t2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Absorbance based Imipenem Antibiotic Synergy Assay (MIC4X): BAA-2146</td><td headers="hd_h_ml302.t2_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Dose Response (2X)</td><td headers="hd_h_ml302.t2_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">NDM-1</td><td headers="hd_h_ml302.t2_1_1_1_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Yes</td></tr><tr><td headers="hd_h_ml302.t2_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/bioassay/624095" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">624095</a></td><td headers="hd_h_ml302.t2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Absorbance based Imipenem Antibiotic Synergy Assay (MIC4X): KN20</td><td headers="hd_h_ml302.t2_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Dose Response (2X)</td><td headers="hd_h_ml302.t2_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">IMP-1</td><td headers="hd_h_ml302.t2_1_1_1_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Yes</td></tr><tr><td headers="hd_h_ml302.t2_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/bioassay/624097" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">624097</a></td><td headers="hd_h_ml302.t2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Absorbance based Imipenem Antibiotic Synergy Assay (MIC4X): BL21</td><td headers="hd_h_ml302.t2_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Dose Response (2X)</td><td headers="hd_h_ml302.t2_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">IMP-1</td><td headers="hd_h_ml302.t2_1_1_1_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Yes</td></tr></tbody></table></div></div><p><i>(also see Summary <a href="https://pubchem.ncbi.nlm.nih.gov/bioassay/1854" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">AID <u>1854</u></a>)</i></p><p><i>VIM-2 Inhibition Assays (Epi-Absorbance-based; Nitrocefin) (PubChem AIDs: <a href="https://pubchem.ncbi.nlm.nih.gov/bioassay/1527" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">AID <u>1527</u></a>,<a href="https://pubchem.ncbi.nlm.nih.gov/bioassay/1860" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">AID <u>1860</u></a>, <a href="https://pubchem.ncbi.nlm.nih.gov/bioassay/1919" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">AID <u>1919</u></a>, <a href="https://pubchem.ncbi.nlm.nih.gov/bioassay/2128" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">AID <u>2128</u></a>, <a href="https://pubchem.ncbi.nlm.nih.gov/bioassay/2317" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">AID <u>2317</u></a></i>, and <i><a href="https://pubchem.ncbi.nlm.nih.gov/bioassay/624079" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">AID <u>624079</u></a></i>). The purpose of this assay is to identify compounds that act as inhibitors of the VIM-2 β-lactamase. This biochemical epi-absorbance-format assay employs the cephalosporin nitrocefin as the VIM-2 substrate, and takes advantage of the fluorescent properties of white microtiter plates [<a class="bk_pop" href="#ml302.r16">16</a>]. Nitrocefin is a yellow chromogenic substrate (Imax = 395 nm) that is hydrolyzed by β-lactamases to yield a red product with increased absorbance properties (Imax = 495 nm) that quenches plate fluorescence by absorbing the plate’s emission light [<a class="bk_pop" href="#ml302.r16">16</a>]. In this assay, test compounds are incubated with purified VIM-2 enzyme and nitrocefin in detergent-containing buffer at room temperature. The reaction is stopped by the addition of EDTA, followed by measurement of well fluorescence. As designed, compounds that inhibit VIM-2 will inhibit nitrocefin hydrolysis, inhibit generation of red product, and inhibit quenching of plate fluorescence, resulting in an increase in well fluorescence. Compounds were tested in singlicate (<a href="https://pubchem.ncbi.nlm.nih.gov/bioassay/1527" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">AID <i><u>1527</u></i></a>) and triplicate (<a href="https://pubchem.ncbi.nlm.nih.gov/bioassay/1860" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">AID <i><u>1860</u></i></a>) at a final nominal concentration of 5.6 μM, in a 10-point 1:3 dilution series starting at a nominal concentration of 55.7 μM (<a href="https://pubchem.ncbi.nlm.nih.gov/bioassay/1919" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">AID <i><u>1919</u></i></a>, <i><a href="https://pubchem.ncbi.nlm.nih.gov/bioassay/2128" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">AID <u>2128</u></a>, <a href="https://pubchem.ncbi.nlm.nih.gov/bioassay/2317" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">AID <u>2317</u></a></i>, and <i><a href="https://pubchem.ncbi.nlm.nih.gov/bioassay/624079" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">AID <u>624079</u></a></i>).</p><p><i>IMP-1 Inhibition Counterscreens (Epi-absorbance-based; Nitrocefin) (<a href="https://pubchem.ncbi.nlm.nih.gov/bioassay/1556" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">AID <u>1556</u></a>, <a href="https://pubchem.ncbi.nlm.nih.gov/bioassay/1856" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">AID <u>1856</u></a>, <a href="https://pubchem.ncbi.nlm.nih.gov/bioassay/1920" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">AID <u>1920</u></a>, <a href="https://pubchem.ncbi.nlm.nih.gov/bioassay/2128" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">AID <u>2128</u></a>, <a href="https://pubchem.ncbi.nlm.nih.gov/bioassay/2317" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">AID <u>2317</u></a></i>, and <i><a href="https://pubchem.ncbi.nlm.nih.gov/bioassay/624085" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">AID <u>624085</u></a></i>). The purpose of this assay is to identify compounds that act as inhibitors of the IMP-1 β-lactamase. This biochemical epi-absorbance-format assay employs the cephalosporin nitrocefin as the IMP-1 substrate, and takes advantage of the fluorescent properties of white microtiter plates [<a class="bk_pop" href="#ml302.r16">16</a>]. This assay also serves as a counterscreen to determine whether compounds identified as possible VIM-2 selective inhibitors are non-selective due to inhibition of IMP-1. Nitrocefin is a yellow chromogenic substrate (Imax = 395 nm) that is hydrolyzed by β-lactamases to yield a red product with increased absorbance properties (Imax = 495 nm) that quenches plate fluorescence by absorbing the plate’s emission light [<a class="bk_pop" href="#ml302.r16">16</a>]. In this assay, test compounds are incubated with purified IMP-1 enzyme and nitrocefin in detergent-containing buffer at room temperature. The reaction is stopped by the addition of EDTA, followed by measurement of well fluorescence. As designed, compounds that inhibit IMP-1 will inhibit nitrocefin hydrolysis, inhibit generation of red product, and inhibit quenching of plate fluorescence, resulting in an increase in well fluorescence. Compounds were tested in singlicate (<a href="https://pubchem.ncbi.nlm.nih.gov/bioassay/1556" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">AID <i><u>1556</u></i></a>) or in triplicate (<a href="https://pubchem.ncbi.nlm.nih.gov/bioassay/1856" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">AID <i><u>1856</u></i></a>) at a final nominal concentration of 5.6 μM, and in triplicate using a dilution series starting at a nominal test concentration of 60 micromolar (<a href="https://pubchem.ncbi.nlm.nih.gov/bioassay/1920" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">AID <i><u>1920</u></i></a>, <i><a href="https://pubchem.ncbi.nlm.nih.gov/bioassay/2128" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">AID <u>2128</u></a>, <a href="https://pubchem.ncbi.nlm.nih.gov/bioassay/2317" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">AID <u>2317</u></a></i>, and <i><a href="https://pubchem.ncbi.nlm.nih.gov/bioassay/624085" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">AID <u>624085</u></a></i>).</p></div><div id="ml302.s6"><h3>2.2. Probe Chemical Characterization</h3><p>The synthesis of the probe and analytical characterization data are probe <a href="/pcsubstance/?term=ML302[synonym]" ref="pagearea=body&targetsite=entrez&targetcat=term&targettype=pubchem">ML302</a> are provided in <a href="#ml302.s7">Section 2.3</a>. <a href="/pcsubstance/?term=ML302[synonym]" ref="pagearea=body&targetsite=entrez&targetcat=term&targettype=pubchem">ML302</a> was obtained with >98% purity according to <sup>1</sup>H NMR and LCMS analysis. However, <a href="/pcsubstance/?term=ML302[synonym]" ref="pagearea=body&targetsite=entrez&targetcat=term&targettype=pubchem">ML302</a> had relatively poor solubility characteristics, so we also generated a more soluble HCl salt, identified as CID53384679. The HCl salt was also obtained with >96% purity by 1H NMR and LCMS analysis.</p><p><i>Solubility</i>. The solubility of probe <a href="/pcsubstance/?term=ML302[synonym]" ref="pagearea=body&targetsite=entrez&targetcat=term&targettype=pubchem">ML302</a> (synthesized and registered by the SRISMC as SR-03000002555-2/<a href="https://pubchem.ncbi.nlm.nih.gov/substance/134220672" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">SID 134220672</a>/CID 53362017) was measured in phosphate buffered saline (PBS: 137 mM NaCl, 2.7 mM KCl, 10 mM sodium phosphate dibasic, 2 mM potassium phosphate monobasic and a pH of 7.4) at room temperature (23°C). The solubility of was found to be <1 μM. In an attempt to achieve improved solubility, a series of salts (including the HCl salt, CID 53384679) were synthesized and studied. However, salt HCl CID 53384679 also had poor solubility (<1 μM) in this standard pH 7.4 PBS buffer assay system. However, probe <a href="/pcsubstance/?term=ML302[synonym]" ref="pagearea=body&targetsite=entrez&targetcat=term&targettype=pubchem">ML302</a> and HCl salt CID53384679 are fully soluble at 100 μM in 70:30 DMSO/water, and both have solubility >100 μM at pH = 3 aqueous solution. A sample of the HCl salt CID 53384679 is also soluble >100 μM in D<sub>2</sub>O (<sup>1</sup>H NMR measurements performed at this concentration). Both probe <a href="/pcsubstance/?term=ML302[synonym]" ref="pagearea=body&targetsite=entrez&targetcat=term&targettype=pubchem">ML302</a> and the HCl salt CID 53384679 are fully soluble under the conditions of the VIM-2 biochemical assays and antibacterial assays described in this probe report.</p><p><i>Stability</i>. The stability of probe <a href="/pcsubstance/?term=ML302[synonym]" ref="pagearea=body&targetsite=entrez&targetcat=term&targettype=pubchem">ML302</a> was measured at room temperature (23ºC) in PBS (no antioxidants or other protectants; DMSO concentration below 0.1%). The stability, represented by the half-life, was found to be very poor. <a class="figpopup" href="/books/NBK143563/figure/ml302.f1/?report=objectonly" target="object" rid-figpopup="figml302f1" rid-ob="figobml302f1">Figure 1</a> provides graphs showing loss of compound with time over a 48 hour period with a minimum of 6 time points. The table at the end of this section indicates the percent of compound remaining at the end of the 48 hours. These data suggest that the probe <a href="/pcsubstance/?term=ML302[synonym]" ref="pagearea=body&targetsite=entrez&targetcat=term&targettype=pubchem">ML302</a> and HCl salt CID 53384679 are highly unstable under these assay conditions. However, these data are not consistent with our experience with these compounds when handled under other conditions. Rather, we suspect that these data reflect solubility problems with the compound under the assay conditions. For example, HCl salt CID 53384679 proved to be fully stable, at 100 μM, in D<sub>2</sub>O over a two-week monitoring period (<sup>1</sup>H NMR study)—conditions under which it is fully soluble. Similarly, probe <a href="/pcsubstance/?term=ML302[synonym]" ref="pagearea=body&targetsite=entrez&targetcat=term&targettype=pubchem">ML302</a> and HCl salt CID 53384679 were fully stable at 100 μM in 70/30 DMSO-D<sub>2</sub>O over a two-week period, in presence of air (<sup>1</sup>H NMR study)—conditions, again, under which they are fully soluble. <a href="/pcsubstance/?term=ML302[synonym]" ref="pagearea=body&targetsite=entrez&targetcat=term&targettype=pubchem">ML302</a> and HCl salt CID 53384679 (both 1 μM) were fully stable (24 h monitoring) at pH 3 in PBS with 20% DMSO, and displayed >93% stability (over 24 h) at pH 7 PBS with 20% DMSO. The latter value undoubtedly reflects the limit of solubility of these compounds under these conditions. Apparently, the HCl salt CID 53384679 is converted to the free base (<a href="/pcsubstance/?term=ML302[synonym]" ref="pagearea=body&targetsite=entrez&targetcat=term&targettype=pubchem">ML302</a>) at pH 7.4.</p><div class="iconblock whole_rhythm clearfix ten_col fig" id="figml302f1" co-legend-rid="figlgndml302f1"><a href="/books/NBK143563/figure/ml302.f1/?report=objectonly" target="object" title="Figure 1" class="img_link icnblk_img figpopup" rid-figpopup="figml302f1" rid-ob="figobml302f1"><img class="small-thumb" src="/books/NBK143563/bin/ml302f1.gif" src-large="/books/NBK143563/bin/ml302f1.jpg" alt="Figure 1. Stability Analysis of ML302 and its HCl salt." /></a><div class="icnblk_cntnt" id="figlgndml302f1"><h4 id="ml302.f1"><a href="/books/NBK143563/figure/ml302.f1/?report=objectonly" target="object" rid-ob="figobml302f1">Figure 1</a></h4><p class="float-caption no_bottom_margin">Stability Analysis of ML302 and its HCl salt. </p></div></div><p><i>Probe <a href="/pcsubstance/?term=ML302[synonym]" ref="pagearea=body&targetsite=entrez&targetcat=term&targettype=pubchem">ML302</a>, and its HCl salt were measured for its ability to form glutathione adducts</i>. At concentrations of 100 μM reduced GSH, 10 μM of the new probe does not appear to be a Michael acceptor [<a class="bk_pop" href="#ml302.r17">17</a>, <a class="bk_pop" href="#ml302.r18">18</a>]. Evidently, the chlorine substituents at the 2,6-position of the phenyl ring hinder the double bond such that these compounds are not highly active as Michael acceptors.</p><div id="ml302.t3" class="table"><h3><span class="label">Table 3</span><span class="title">Solubility of ML302</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK143563/table/ml302.t3/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ml302.t3_lrgtbl__"><table class="no_top_margin"><thead><tr><th id="hd_h_ml302.t3_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Compound</th><th id="hd_h_ml302.t3_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">MW</th><th id="hd_h_ml302.t3_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR Number</th><th id="hd_h_ml302.t3_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">CID</th><th id="hd_h_ml302.t3_1_1_1_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SID</th><th id="hd_h_ml302.t3_1_1_1_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Solubility in PBS (μM)</th><th id="hd_h_ml302.t3_1_1_1_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Michael Acceptor 100 μM GSH trap</th><th id="hd_h_ml302.t3_1_1_1_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Stability in PBS<br />t1/2 (hr)</th></tr></thead><tbody><tr><td headers="hd_h_ml302.t3_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">New Probe <a href="/pcsubstance/?term=ML302[synonym]" ref="pagearea=body&targetsite=entrez&targetcat=term&targettype=pubchem">ML302</a></td><td headers="hd_h_ml302.t3_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">479.8</td><td headers="hd_h_ml302.t3_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-03000002555-2</td><td headers="hd_h_ml302.t3_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">53362017</td><td headers="hd_h_ml302.t3_1_1_1_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/134220672" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">134220672</a></td><td headers="hd_h_ml302.t3_1_1_1_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><1 μM</td><td headers="hd_h_ml302.t3_1_1_1_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">No</td><td headers="hd_h_ml302.t3_1_1_1_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="#ml302.s6">Section 2.2</a></td></tr><tr><td headers="hd_h_ml302.t3_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Probe <a href="/pcsubstance/?term=ML302[synonym]" ref="pagearea=body&targetsite=entrez&targetcat=term&targettype=pubchem">ML302</a><br />HCl salt</td><td headers="hd_h_ml302.t3_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">516.3</td><td headers="hd_h_ml302.t3_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-03000002594-2</td><td headers="hd_h_ml302.t3_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">53384679</td><td headers="hd_h_ml302.t3_1_1_1_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/134220676" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">134220676</a> (synthesis)</td><td headers="hd_h_ml302.t3_1_1_1_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><1 μM</td><td headers="hd_h_ml302.t3_1_1_1_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">No</td><td headers="hd_h_ml302.t3_1_1_1_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="#ml302.s6">Section 2.2</a></td></tr></tbody></table></div></div></div><div id="ml302.s7"><h3>2.3. Probe Preparation</h3><p>VIM-2 inhibitor probe <a href="/pcsubstance/?term=ML302[synonym]" ref="pagearea=body&targetsite=entrez&targetcat=term&targettype=pubchem">ML302</a> was synthesized by a two-step procedure involving the condensation of 2,3,6-trichlorobenzaldehyde with rhodanine-3-acetic acid, followed by coupling of the product carboxylic acid <b>1</b> with 1-amino-4-methyl-piperazine [<a class="bk_pop" href="#ml302.r19">19</a>].</p><p>2,3,6-Trichlorobenzaldehdye (1.676 g, 8.0 mmol, 1 equiv, purchased from Oakwood Product, Inc. # 043332) and rhodanine-3-acetic acid (1.530 g, 8.0 mmol, 1 equiv, purchased from Alfa Aesar, # B22244-06) were weighed into a 20-mL microwave vial. Ethanol (16 mL, to give a reaction concentration of 0.5 M) was added followed by piperidine (4 drops). The vial was sealed and submitted to microwave irradiation at 120 °C for 1 h. The solvent was then removed and the crude product was recrystallized from hot ethanol and water. The solid was filtered, rinsed with water and dried under high vacuum yielding compound <b>1</b> as a yellow solid (2.59 g, 85%): <sup><b>1</b></sup><b>H NMR</b> (400 MHz, <i>d6</i>-DMSO) δ 13.56 (1H, br s), 7.84 (1H, s), 7.87-7.84 (1H, m), 7.81 (1H, d, <i>J</i> = 8.8 Hz), 7.67 (1H, d, <i>J</i> = 8.7Hz), 4.70 (2H, s). <sup><b>13</b></sup><b>C NMR</b> (100 MHz, <i>d6</i>-DMSO) δ 192.6, 167.2, 164.9, 133.0, 132.2, 131.5, 131.4, 131.2, 131.1, 129.8, 128.6, 45.6.</p><p>A solution of <b>1</b> (76 mg, 0.2 mmol, 1 equiv.) and BOPCl (61 mg, 0.24 mmol, 1.2 equiv) in dichloromethane (2 mL, to give a reaction concentration of 0.1 M) in a 5-mL round-bottomed flask was cooled to 0 °C using an ice/water bath under an inert atmosphere. Freshly distilled triethylamine (35 μL, 0.24 mmol, 1.2 equiv) was added and the solution was allowed to stir at 0 °C for 30 min. The cold bath was removed and 1-amino-4-methyl-piperazine (29 μL, 0.24 mmol, 1.2 equiv, purchased from Acros Organics, # 251391000) was added. The mixture was allowed to warm to room temperature and was stirred overnight. The crude product, obtained by removal of all solvents volatile compounds in vacuo, was directly purified by flash chromatography (silica gel, dichloromethane-methanol 90/10, R<sub><i>f</i></sub> = 0.29) yielding compound <b>2</b> as an inseparable mixture of <i>E</i>/<i>Z</i> isomers in a 1:3 ratio (75 mg, 78 %, yellow solid, mp = 184–186 °C) (<a class="figpopup" href="/books/NBK143563/figure/ml302.f2/?report=objectonly" target="object" rid-figpopup="figml302f2" rid-ob="figobml302f2">Figure 2</a>). The chemical purity of <b>2</b> is >98% according to HLPC analysis.</p><div class="iconblock whole_rhythm clearfix ten_col fig" id="figml302f2" co-legend-rid="figlgndml302f2"><a href="/books/NBK143563/figure/ml302.f2/?report=objectonly" target="object" title="Figure 2" class="img_link icnblk_img figpopup" rid-figpopup="figml302f2" rid-ob="figobml302f2"><img class="small-thumb" src="/books/NBK143563/bin/ml302f2.gif" src-large="/books/NBK143563/bin/ml302f2.jpg" alt="Figure 2. Synthesis of VIM-2 Inhibitor Probe CID 53362017 (ML302) (Compound 2)." /></a><div class="icnblk_cntnt" id="figlgndml302f2"><h4 id="ml302.f2"><a href="/books/NBK143563/figure/ml302.f2/?report=objectonly" target="object" rid-ob="figobml302f2">Figure 2</a></h4><p class="float-caption no_bottom_margin">Synthesis of VIM-2 Inhibitor Probe CID 53362017 (ML302) (Compound 2). </p></div></div><p><b>Data for VIM-2 Inhibitor</b>
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<u><b>Probe, CID 53362017 (Compound 2),</b>
|
||
<b><i>Z</i></b>
|
||
<b>isomer (major)</b></u>: <sup><b>1</b></sup><b>H NMR</b> (400 MHz, <i>d6</i>-DMSO) δ 9.08 (1H, s), 7.83 (1H, s), 7.82 (1H, d, <i>J</i> = 8.7 Hz), 7.68 (1H, d, <i>J</i> = 8.8 Hz), 4.91 (2H, s), 2.99-2.62 (6H, m), 2.43-2.02 (2H, m), 2.17 (3H, s); <sup><b>13</b></sup><b>C NMR</b> (100 MHz, <i>d6</i>-DMSO) δ 192.8, 166.0, 165.1, 133.0, 132.2, 131.5, 131.4, 131.3, 131.2, 129.8, 128.2, 55.1, 54.3, 45.3, 45.2. <b>MS</b> ([M+H]+): 481.1 (100%), 479.4 (71%), 483.0 (39%). <b>IR</b> (cm<sup>−1</sup>): 3049, 2927, 2808, 1731, 1687, 1627, 1402, 1366, 1323, 1286, 1273, 1193, 1175, 1051, 1008, 816, 725.</p><p><b>Partial Data for (minor) E isomer of VIM-2 Inhibitor Probe</b>
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<u><b>CID 53362017</b></u>: <sup><b>1</b></sup><b>H NMR</b> (400 MHz, <i>d6</i>-DMSO) δ 9.37 (1H, s), 7.82 (1H, d, <i>J</i> = 8.7 Hz), 7.81 (1H, s), 7.68 (1H, d, <i>J</i> = 8.8 Hz), 4.56 (2H, s), 2.99-2.62 (6H, m), 2.43-2.02 (2H, m), 2.15 (3H, s).</p><p>All anti-bacterial and enzyme assays performed with the VIM-2 inhibitor probe, CID 53362017 (compound 2) were performed with the 3:1 mixture of olefin isomers. The two olefin isomers of the Probe were not separated, since prior studies with three probe analogs (SR-6818, SR-2448 and SR-2450) (<a class="figpopup" href="/books/NBK143563/figure/ml302.f3/?report=objectonly" target="object" rid-figpopup="figml302f3" rid-ob="figobml302f3">Figure 3</a>) indicated that the separated olefin isomers rapidly re-isomerized to the original 3:1 mixtures. (The olefin isomers of SR-6818, SR-2448 and SR-2450 were separated by preparative HPLC. In all three cases, the separated isomers had converted back to the original 3:1 mixtures in the time required to concentrate the HPLC fractions prior to NMR analysis).</p><div class="iconblock whole_rhythm clearfix ten_col fig" id="figml302f3" co-legend-rid="figlgndml302f3"><a href="/books/NBK143563/figure/ml302.f3/?report=objectonly" target="object" title="Figure 3" class="img_link icnblk_img figpopup" rid-figpopup="figml302f3" rid-ob="figobml302f3"><img class="small-thumb" src="/books/NBK143563/bin/ml302f3.gif" src-large="/books/NBK143563/bin/ml302f3.jpg" alt="Figure 3. Probe analogs." /></a><div class="icnblk_cntnt" id="figlgndml302f3"><h4 id="ml302.f3"><a href="/books/NBK143563/figure/ml302.f3/?report=objectonly" target="object" rid-ob="figobml302f3">Figure 3</a></h4><p class="float-caption no_bottom_margin">Probe analogs. </p></div></div><p>A solution of hydrogen chloride in dioxane (4.0M, 4.1 mL, 16.4 mmol, 80 equiv) was slowly added at 0 °C to compound <b>2</b> (100 mg, 0.21 mmol, 1 equiv) under an inert atmosphere. The cold bath was removed and the mixture was allowed to stir at room temperature for 4 h. The resulting heterogeneous solution was filtered and the yellow precipitate <b>3</b> (<a class="figpopup" href="/books/NBK143563/figure/ml302.f4/?report=objectonly" target="object" rid-figpopup="figml302f4" rid-ob="figobml302f4">Figure 4</a>) was thoroughly washed with diethyl ether and dried under vacuum. No further purification was performed and the hydrochloride salt was obtained as a mixture of <i>E</i>/<i>Z</i> isomers in a 1:1 ratio (96 mg, 89 %, yellow solid, mp = 203–206 °C).</p><div class="iconblock whole_rhythm clearfix ten_col fig" id="figml302f4" co-legend-rid="figlgndml302f4"><a href="/books/NBK143563/figure/ml302.f4/?report=objectonly" target="object" title="Figure 4" class="img_link icnblk_img figpopup" rid-figpopup="figml302f4" rid-ob="figobml302f4"><img class="small-thumb" src="/books/NBK143563/bin/ml302f4.gif" src-large="/books/NBK143563/bin/ml302f4.jpg" alt="Figure 4. Synthesis of Hydrochloride Salt of the Probe (CID 53384679, Compound 3)." /></a><div class="icnblk_cntnt" id="figlgndml302f4"><h4 id="ml302.f4"><a href="/books/NBK143563/figure/ml302.f4/?report=objectonly" target="object" rid-ob="figobml302f4">Figure 4</a></h4><p class="float-caption no_bottom_margin">Synthesis of Hydrochloride Salt of the Probe (CID 53384679, Compound 3). </p></div></div><p><b>Data for VIM-2 Inhibitor</b>
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<u><b>CID 53384679 (Compound 3),</b>
|
||
<b><i>Z</i></b>
|
||
<b>isomer</b></u>: <sup><b>1</b></sup><b>H NMR</b> (400 MHz, <i>d6</i>-DMSO) δ 11.21 (1H, br s), 9.41 (1H, s), 7.82 (1H, s), 7.81 (1H, d, <i>J</i> = 8.5 Hz), 7.67 (1H, d, <i>J</i> = 8.5 Hz), 4.99 (2H, s), 3.49-3.00 (8H, m), 2.73 (3H, s); <sup><b>13</b></sup><b>C NMR</b> (100 MHz, <i>d6</i>-DMSO) δ 192.8, 165.1, 162.1, 132.9, 132.2, 131.5, 131.4, 131.2, 131.1, 129.8, 128.3, 52.5, 51.8, 50.7, 45.3. <b>MS</b> ([M+H]+): 481.1 (100%), 479.5 (74%), 483.0 (38%). <b>IR</b> (cm<sup>−1</sup>): 2936, 2464, 1724, 1692, 1564, 1437, 1335, 1190, 1176, 1100, 1055, 984, 898, 814.</p><p><b>Partial Data for E isomer of VIM-2 Inhibitor Compound 3</b>
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<u><b>CID 53384679</b></u>: <sup><b>1</b></sup><b>H NMR</b> (400 MHz, <i>d6</i>-DMSO) δ 11.21 (1H, br s), 9.97 (1H, s), 7.81 (1H, d, <i>J</i> = 8.5 Hz), 7.80 (1H, s), 7.67 (1H, d, <i>J</i> = 8.5 Hz), 4.60 (2H, s), 3.49-3.00 (8H, m), 2.71 (3H, s).</p></div></div><div id="ml302.s8"><h2 id="_ml302_s8_">3. Results</h2><div id="ml302.s9"><h3>3.1. Summary of Screening Results</h3><p>During the medicinal chemistry effort following our initial VIM-2 selective inhibitor project, the rhodanine scaffold, exemplified by SR-01000216818/CID1733268, exhibited activity against the anti-target enzyme, IMP-1. This suggested that this scaffold could be a source of broader-acting dual inhibitors of bacterial MBLs which might serve as tools for novel antibiotic discovery. In order to assess the efficacy of the new scaffold, we tested powder samples of leads in a series of biochemical and bacterial-based assays. Initial studies with recombinant VIM-2 protein revealed that several compounds in this scaffold exhibited potencies less than 5 micromolar. <i>The broad acting MBL probe (<a href="/pcsubstance/?term=ML302[synonym]" ref="pagearea=body&targetsite=entrez&targetcat=term&targettype=pubchem">ML302</a>) was identified from this scaffold.</i></p></div><div id="ml302.s10"><h3>3.2. Dose Response Curves for Probes</h3><p>Dose response curves for probe <a href="/pcsubstance/?term=ML302[synonym]" ref="pagearea=body&targetsite=entrez&targetcat=term&targettype=pubchem">ML302</a> are shown in <a class="figpopup" href="/books/NBK143563/figure/ml302.f5/?report=objectonly" target="object" rid-figpopup="figml302f5" rid-ob="figobml302f5">Figure 5</a> against all enzymes tested. The probe shows selective potency to the VIM-2 and IMP-1 enzymes. For comparison, SR-01000216818/CID 1733268 (“Analog 7”) is also graphed. Potency values are reported in the cover page of this report.</p><div class="iconblock whole_rhythm clearfix ten_col fig" id="figml302f5" co-legend-rid="figlgndml302f5"><a href="/books/NBK143563/figure/ml302.f5/?report=objectonly" target="object" title="Figure 5" class="img_link icnblk_img figpopup" rid-figpopup="figml302f5" rid-ob="figobml302f5"><img class="small-thumb" src="/books/NBK143563/bin/ml302f5.gif" src-large="/books/NBK143563/bin/ml302f5.jpg" alt="Figure 5. Dose response curves for ML302." /></a><div class="icnblk_cntnt" id="figlgndml302f5"><h4 id="ml302.f5"><a href="/books/NBK143563/figure/ml302.f5/?report=objectonly" target="object" rid-ob="figobml302f5">Figure 5</a></h4><p class="float-caption no_bottom_margin">Dose response curves for ML302. </p></div></div></div><div id="ml302.s11"><h3>3.3. Scaffold/Moiety Chemical Liabilities</h3><p>There is no known instability or chemical liabilities associated with the chemical scaffold of probe <a href="/pcsubstance/?term=ML302[synonym]" ref="pagearea=body&targetsite=entrez&targetcat=term&targettype=pubchem">ML302</a>. The compounds appear to be fully stable during all routine handling operations (synthesis chromatographic purification of the probe, NMR studies, storage as powders, etc.). Issues with solubility of the probe and its HCl salt are discussed in a previous section. The only issue we have observed is that the probe and its HCl salt are unstable at pH 10, due to amide hydrolysis at this basic pH. Therefore, handling of probe <a href="/pcsubstance/?term=ML302[synonym]" ref="pagearea=body&targetsite=entrez&targetcat=term&targettype=pubchem">ML302</a> at pH > 7.4 is not recommended.</p></div><div id="ml302.s12"><h3>3.4. SAR Tables</h3><p><b>Describe SAR & chemistry strategy (including structure and data) that led to the probe.</b> Following submission of our initial probe report describing a <i>selective</i> VIM-2 inhibitor probe (<a href="/pcsubstance/?term=ML121[synonym]" ref="pagearea=body&targetsite=entrez&targetcat=term&targettype=pubchem">ML121</a>), compounds in the rhodanine scaffold appeared to have activity for both VIM-2 and IMP-1, suggesting a broad-acting MBL inhibitor probe could be developed. Powder and re-synthesized samples of selected compounds were tested by the assay provider in several biochemical and bacterial assays to determine potency, efficacy, and selectivity. These efforts resulted in probe <a href="/pcsubstance/?term=ML302[synonym]" ref="pagearea=body&targetsite=entrez&targetcat=term&targettype=pubchem">ML302</a> and related analogs. The synthesis of <a href="/pcsubstance/?term=ML302[synonym]" ref="pagearea=body&targetsite=entrez&targetcat=term&targettype=pubchem">ML302</a>, presented in <a href="#ml302.s7">Section 2.3</a> of this probe report, is amenable to synthesis of additional analogs by substituting different aldehydes instead of 2,3,6-trichlorobenzaldehyde using the condensation of rhodanine-3-acetic acid; use of different amines instead of 1-amino-4-methyl-piperazine in the coupling with carboxylic acid <b>1</b>. As summarized in the following SAR tables, more than 90 such analogs have been synthesized and tested. Preliminary efforts indicate that introduction of amino acid side chains in the rhodanine scaffold also lead to active compounds. Additional studies of such analogs will be performed in the future.</p><div id="ml302.tu2" class="table"><h3><span class="title">Metallo-beta Lactamase Inhibitor SAR Table: Rhodanine Scaffold</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK143563/table/ml302.tu2/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ml302.tu2_lrgtbl__"><table class="no_top_margin"><thead><tr><th id="hd_h_ml302.tu2_1_1_1_1" colspan="8" rowspan="1" style="text-align:center;vertical-align:middle;">Compound Information</th><th id="hd_h_ml302.tu2_1_1_1_2" colspan="12" rowspan="1" style="text-align:center;vertical-align:middle;">Bioassays</th><th id="hd_h_ml302.tu2_1_1_1_3" colspan="8" rowspan="1" style="text-align:center;vertical-align:middle;">Biochemical Assays</th></tr><tr><th headers="hd_h_ml302.tu2_1_1_1_1 hd_h_ml302.tu2_1_1_2_1" id="hd_h_ml302.tu2_1_1_2_1" rowspan="2" colspan="1" style="text-align:center;vertical-align:middle;">Compound</th><th headers="hd_h_ml302.tu2_1_1_1_1 hd_h_ml302.tu2_1_1_2_2" id="hd_h_ml302.tu2_1_1_2_2" rowspan="2" colspan="1" style="text-align:center;vertical-align:middle;">SR-Number</th><th headers="hd_h_ml302.tu2_1_1_1_1 hd_h_ml302.tu2_1_1_2_3" id="hd_h_ml302.tu2_1_1_2_3" rowspan="2" colspan="1" style="text-align:center;vertical-align:middle;">Structure</th><th headers="hd_h_ml302.tu2_1_1_1_1 hd_h_ml302.tu2_1_1_2_4" id="hd_h_ml302.tu2_1_1_2_4" rowspan="2" colspan="1" style="text-align:center;vertical-align:middle;">CID</th><th headers="hd_h_ml302.tu2_1_1_1_1 hd_h_ml302.tu2_1_1_2_5" id="hd_h_ml302.tu2_1_1_2_5" rowspan="2" colspan="1" style="text-align:center;vertical-align:middle;">SID</th><th headers="hd_h_ml302.tu2_1_1_1_1 hd_h_ml302.tu2_1_1_2_6" id="hd_h_ml302.tu2_1_1_2_6" rowspan="2" colspan="1" style="text-align:center;vertical-align:middle;">MLS</th><th headers="hd_h_ml302.tu2_1_1_1_1 hd_h_ml302.tu2_1_1_2_7" id="hd_h_ml302.tu2_1_1_2_7" rowspan="2" colspan="1" style="text-align:center;vertical-align:middle;">Vendor</th><th headers="hd_h_ml302.tu2_1_1_1_1 hd_h_ml302.tu2_1_1_2_8" id="hd_h_ml302.tu2_1_1_2_8" rowspan="2" colspan="1" style="text-align:center;vertical-align:middle;">Vendor Catalog ID</th><th headers="hd_h_ml302.tu2_1_1_1_2" id="hd_h_ml302.tu2_1_1_2_9" colspan="2" rowspan="1" style="text-align:center;vertical-align:middle;">BL21 (VIM-2)</th><th headers="hd_h_ml302.tu2_1_1_1_2" id="hd_h_ml302.tu2_1_1_2_10" colspan="2" rowspan="1" style="text-align:center;vertical-align:middle;">YMC07/B3323 (VIM-</th><th headers="hd_h_ml302.tu2_1_1_1_2" id="hd_h_ml302.tu2_1_1_2_11" colspan="2" rowspan="1" style="text-align:center;vertical-align:middle;">BAA-2146 (NDM-1)</th><th headers="hd_h_ml302.tu2_1_1_1_2" id="hd_h_ml302.tu2_1_1_2_12" colspan="2" rowspan="1" style="text-align:center;vertical-align:middle;">PA641 (VIM-2)</th><th headers="hd_h_ml302.tu2_1_1_1_2" id="hd_h_ml302.tu2_1_1_2_13" colspan="2" rowspan="1" style="text-align:center;vertical-align:middle;">KN20 (IMP-1)</th><th headers="hd_h_ml302.tu2_1_1_1_2" id="hd_h_ml302.tu2_1_1_2_14" colspan="2" rowspan="1" style="text-align:center;vertical-align:middle;">BL21 (IMP-1)</th><th headers="hd_h_ml302.tu2_1_1_1_3" id="hd_h_ml302.tu2_1_1_2_15" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">VIM-2</th><th headers="hd_h_ml302.tu2_1_1_1_3" id="hd_h_ml302.tu2_1_1_2_16" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">IMP-1</th><th headers="hd_h_ml302.tu2_1_1_1_3" id="hd_h_ml302.tu2_1_1_2_17" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">TEM-1</th><th headers="hd_h_ml302.tu2_1_1_1_3" id="hd_h_ml302.tu2_1_1_2_18" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">AmpC</th><th headers="hd_h_ml302.tu2_1_1_1_3" id="hd_h_ml302.tu2_1_1_2_19" colspan="2" rowspan="1" style="text-align:center;vertical-align:middle;">VIM-2 Ki</th><th headers="hd_h_ml302.tu2_1_1_1_3" id="hd_h_ml302.tu2_1_1_2_20" colspan="2" rowspan="1" style="text-align:center;vertical-align:middle;">IMP-1 Ki Assay</th></tr><tr><th headers="hd_h_ml302.tu2_1_1_1_2 hd_h_ml302.tu2_1_1_2_9" id="hd_h_ml302.tu2_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">MIC 4× (μM)</th><th headers="hd_h_ml302.tu2_1_1_1_2 hd_h_ml302.tu2_1_1_2_9" id="hd_h_ml302.tu2_1_1_3_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Imipenem Potentiation</th><th headers="hd_h_ml302.tu2_1_1_1_2 hd_h_ml302.tu2_1_1_2_10" id="hd_h_ml302.tu2_1_1_3_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">MIC 4× (μM)</th><th headers="hd_h_ml302.tu2_1_1_1_2 hd_h_ml302.tu2_1_1_2_10" id="hd_h_ml302.tu2_1_1_3_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Imipenem Potentiation</th><th headers="hd_h_ml302.tu2_1_1_1_2 hd_h_ml302.tu2_1_1_2_11" id="hd_h_ml302.tu2_1_1_3_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">MIC 4× (μM)</th><th headers="hd_h_ml302.tu2_1_1_1_2 hd_h_ml302.tu2_1_1_2_11" id="hd_h_ml302.tu2_1_1_3_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Imipenem Potentiation</th><th headers="hd_h_ml302.tu2_1_1_1_2 hd_h_ml302.tu2_1_1_2_12" id="hd_h_ml302.tu2_1_1_3_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">MIC 4× (μM)</th><th headers="hd_h_ml302.tu2_1_1_1_2 hd_h_ml302.tu2_1_1_2_12" id="hd_h_ml302.tu2_1_1_3_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Imipenem Potentiation</th><th headers="hd_h_ml302.tu2_1_1_1_2 hd_h_ml302.tu2_1_1_2_13" id="hd_h_ml302.tu2_1_1_3_9" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">MIC 4× (μM)</th><th headers="hd_h_ml302.tu2_1_1_1_2 hd_h_ml302.tu2_1_1_2_13" id="hd_h_ml302.tu2_1_1_3_10" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Imipenem Potentiation</th><th headers="hd_h_ml302.tu2_1_1_1_2 hd_h_ml302.tu2_1_1_2_14" id="hd_h_ml302.tu2_1_1_3_11" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">MIC 4× (μM)</th><th headers="hd_h_ml302.tu2_1_1_1_2 hd_h_ml302.tu2_1_1_2_14" id="hd_h_ml302.tu2_1_1_3_12" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Imipenem Potentiation</th><th headers="hd_h_ml302.tu2_1_1_1_3 hd_h_ml302.tu2_1_1_2_15" id="hd_h_ml302.tu2_1_1_3_13" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">IC50 (uM)</th><th headers="hd_h_ml302.tu2_1_1_1_3 hd_h_ml302.tu2_1_1_2_16" id="hd_h_ml302.tu2_1_1_3_14" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">IC50 (uM)</th><th headers="hd_h_ml302.tu2_1_1_1_3 hd_h_ml302.tu2_1_1_2_17" id="hd_h_ml302.tu2_1_1_3_15" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">IC50 (uM)</th><th headers="hd_h_ml302.tu2_1_1_1_3 hd_h_ml302.tu2_1_1_2_18" id="hd_h_ml302.tu2_1_1_3_16" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">IC50 (uM)</th><th headers="hd_h_ml302.tu2_1_1_1_3 hd_h_ml302.tu2_1_1_2_19" id="hd_h_ml302.tu2_1_1_3_17" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Ki (nM)</th><th headers="hd_h_ml302.tu2_1_1_1_3 hd_h_ml302.tu2_1_1_2_19" id="hd_h_ml302.tu2_1_1_3_18" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Km (uM)</th><th headers="hd_h_ml302.tu2_1_1_1_3 hd_h_ml302.tu2_1_1_2_20" id="hd_h_ml302.tu2_1_1_3_19" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Ki (nM)</th><th headers="hd_h_ml302.tu2_1_1_1_3 hd_h_ml302.tu2_1_1_2_20" id="hd_h_ml302.tu2_1_1_3_20" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Km (uM)</th></tr></thead><tbody><tr><td headers="hd_h_ml302.tu2_1_1_1_1 hd_h_ml302.tu2_1_1_2_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Probe</td><td headers="hd_h_ml302.tu2_1_1_1_1 hd_h_ml302.tu2_1_1_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-03000002555-1</td><td headers="hd_h_ml302.tu2_1_1_1_1 hd_h_ml302.tu2_1_1_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">
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<div class="graphic"><img src="/books/NBK143563/bin/ml302fu2.jpg" alt="Image ml302fu2.jpg" /></div></td><td headers="hd_h_ml302.tu2_1_1_1_1 hd_h_ml302.tu2_1_1_2_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">53362017</td><td headers="hd_h_ml302.tu2_1_1_1_1 hd_h_ml302.tu2_1_1_2_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/125264855" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">125264855</a></td><td headers="hd_h_ml302.tu2_1_1_1_1 hd_h_ml302.tu2_1_1_2_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_1_1_1 hd_h_ml302.tu2_1_1_2_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">TSRI</td><td headers="hd_h_ml302.tu2_1_1_1_1 hd_h_ml302.tu2_1_1_2_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">None</td><td headers="hd_h_ml302.tu2_1_1_1_2 hd_h_ml302.tu2_1_1_2_9 hd_h_ml302.tu2_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">3.125</td><td headers="hd_h_ml302.tu2_1_1_1_2 hd_h_ml302.tu2_1_1_2_9 hd_h_ml302.tu2_1_1_3_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">8X</td><td headers="hd_h_ml302.tu2_1_1_1_2 hd_h_ml302.tu2_1_1_2_10 hd_h_ml302.tu2_1_1_3_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0.781</td><td headers="hd_h_ml302.tu2_1_1_1_2 hd_h_ml302.tu2_1_1_2_10 hd_h_ml302.tu2_1_1_3_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">32X</td><td headers="hd_h_ml302.tu2_1_1_1_2 hd_h_ml302.tu2_1_1_2_11 hd_h_ml302.tu2_1_1_3_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">>50</td><td headers="hd_h_ml302.tu2_1_1_1_2 hd_h_ml302.tu2_1_1_2_11 hd_h_ml302.tu2_1_1_3_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">2X</td><td headers="hd_h_ml302.tu2_1_1_1_2 hd_h_ml302.tu2_1_1_2_12 hd_h_ml302.tu2_1_1_3_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">50</td><td headers="hd_h_ml302.tu2_1_1_1_2 hd_h_ml302.tu2_1_1_2_12 hd_h_ml302.tu2_1_1_3_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">4X</td><td headers="hd_h_ml302.tu2_1_1_1_2 hd_h_ml302.tu2_1_1_2_13 hd_h_ml302.tu2_1_1_3_9" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">>50</td><td headers="hd_h_ml302.tu2_1_1_1_2 hd_h_ml302.tu2_1_1_2_13 hd_h_ml302.tu2_1_1_3_10" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">2X</td><td headers="hd_h_ml302.tu2_1_1_1_2 hd_h_ml302.tu2_1_1_2_14 hd_h_ml302.tu2_1_1_3_11" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0.781</td><td headers="hd_h_ml302.tu2_1_1_1_2 hd_h_ml302.tu2_1_1_2_14 hd_h_ml302.tu2_1_1_3_12" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_1_1_3 hd_h_ml302.tu2_1_1_2_15 hd_h_ml302.tu2_1_1_3_13" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0.5481</td><td headers="hd_h_ml302.tu2_1_1_1_3 hd_h_ml302.tu2_1_1_2_16 hd_h_ml302.tu2_1_1_3_14" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">3.018</td><td headers="hd_h_ml302.tu2_1_1_1_3 hd_h_ml302.tu2_1_1_2_17 hd_h_ml302.tu2_1_1_3_15" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">>60</td><td headers="hd_h_ml302.tu2_1_1_1_3 hd_h_ml302.tu2_1_1_2_18 hd_h_ml302.tu2_1_1_3_16" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">>60</td><td headers="hd_h_ml302.tu2_1_1_1_3 hd_h_ml302.tu2_1_1_2_19 hd_h_ml302.tu2_1_1_3_17" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_1_1_3 hd_h_ml302.tu2_1_1_2_19 hd_h_ml302.tu2_1_1_3_18" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_1_1_3 hd_h_ml302.tu2_1_1_2_20 hd_h_ml302.tu2_1_1_3_19" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_1_1_3 hd_h_ml302.tu2_1_1_2_20 hd_h_ml302.tu2_1_1_3_20" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td></tr><tr><td headers="hd_h_ml302.tu2_1_1_1_1 hd_h_ml302.tu2_1_1_2_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Probe <a href="/pcsubstance/?term=ML302[synonym]" ref="pagearea=body&targetsite=entrez&targetcat=term&targettype=pubchem">ML302</a> (Sample to NIH)</td><td headers="hd_h_ml302.tu2_1_1_1_1 hd_h_ml302.tu2_1_1_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-03000002555-2</td><td headers="hd_h_ml302.tu2_1_1_1_1 hd_h_ml302.tu2_1_1_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">
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<div class="graphic"><img src="/books/NBK143563/bin/ml302fu2.jpg" alt="Image ml302fu2.jpg" /></div></td><td headers="hd_h_ml302.tu2_1_1_1_1 hd_h_ml302.tu2_1_1_2_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">53362017</td><td headers="hd_h_ml302.tu2_1_1_1_1 hd_h_ml302.tu2_1_1_2_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/134220672" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">134220672</a></td><td headers="hd_h_ml302.tu2_1_1_1_1 hd_h_ml302.tu2_1_1_2_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">003940491</td><td headers="hd_h_ml302.tu2_1_1_1_1 hd_h_ml302.tu2_1_1_2_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">TSRI</td><td headers="hd_h_ml302.tu2_1_1_1_1 hd_h_ml302.tu2_1_1_2_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">None</td><td headers="hd_h_ml302.tu2_1_1_1_2 hd_h_ml302.tu2_1_1_2_9 hd_h_ml302.tu2_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_1_1_2 hd_h_ml302.tu2_1_1_2_9 hd_h_ml302.tu2_1_1_3_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_1_1_2 hd_h_ml302.tu2_1_1_2_10 hd_h_ml302.tu2_1_1_3_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0.391</td><td headers="hd_h_ml302.tu2_1_1_1_2 hd_h_ml302.tu2_1_1_2_10 hd_h_ml302.tu2_1_1_3_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">32X</td><td headers="hd_h_ml302.tu2_1_1_1_2 hd_h_ml302.tu2_1_1_2_11 hd_h_ml302.tu2_1_1_3_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_1_1_2 hd_h_ml302.tu2_1_1_2_11 hd_h_ml302.tu2_1_1_3_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_1_1_2 hd_h_ml302.tu2_1_1_2_12 hd_h_ml302.tu2_1_1_3_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_1_1_2 hd_h_ml302.tu2_1_1_2_12 hd_h_ml302.tu2_1_1_3_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_1_1_2 hd_h_ml302.tu2_1_1_2_13 hd_h_ml302.tu2_1_1_3_9" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_1_1_2 hd_h_ml302.tu2_1_1_2_13 hd_h_ml302.tu2_1_1_3_10" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_1_1_2 hd_h_ml302.tu2_1_1_2_14 hd_h_ml302.tu2_1_1_3_11" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_1_1_2 hd_h_ml302.tu2_1_1_2_14 hd_h_ml302.tu2_1_1_3_12" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_1_1_3 hd_h_ml302.tu2_1_1_2_15 hd_h_ml302.tu2_1_1_3_13" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_1_1_3 hd_h_ml302.tu2_1_1_2_16 hd_h_ml302.tu2_1_1_3_14" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_1_1_3 hd_h_ml302.tu2_1_1_2_17 hd_h_ml302.tu2_1_1_3_15" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_1_1_3 hd_h_ml302.tu2_1_1_2_18 hd_h_ml302.tu2_1_1_3_16" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_1_1_3 hd_h_ml302.tu2_1_1_2_19 hd_h_ml302.tu2_1_1_3_17" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">183 +/− 24</td><td headers="hd_h_ml302.tu2_1_1_1_3 hd_h_ml302.tu2_1_1_2_19 hd_h_ml302.tu2_1_1_3_18" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">14.8 +/− 3 Mixed mode inhibitor</td><td headers="hd_h_ml302.tu2_1_1_1_3 hd_h_ml302.tu2_1_1_2_20 hd_h_ml302.tu2_1_1_3_19" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">930 +/− 97</td><td headers="hd_h_ml302.tu2_1_1_1_3 hd_h_ml302.tu2_1_1_2_20 hd_h_ml302.tu2_1_1_3_20" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">6.4 +/− 1.3 Mixed mode inhibitor</td></tr><tr><td headers="hd_h_ml302.tu2_1_1_1_1 hd_h_ml302.tu2_1_1_2_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Analog 1</td><td headers="hd_h_ml302.tu2_1_1_1_1 hd_h_ml302.tu2_1_1_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-03000002674-1</td><td headers="hd_h_ml302.tu2_1_1_1_1 hd_h_ml302.tu2_1_1_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">
|
||
<div class="graphic"><img src="/books/NBK143563/bin/ml302fu3.jpg" alt="Image ml302fu3.jpg" /></div></td><td headers="hd_h_ml302.tu2_1_1_1_1 hd_h_ml302.tu2_1_1_2_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">53495083</td><td headers="hd_h_ml302.tu2_1_1_1_1 hd_h_ml302.tu2_1_1_2_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/126723255" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">126723255</a></td><td headers="hd_h_ml302.tu2_1_1_1_1 hd_h_ml302.tu2_1_1_2_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">003940492</td><td headers="hd_h_ml302.tu2_1_1_1_1 hd_h_ml302.tu2_1_1_2_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">TSRI</td><td headers="hd_h_ml302.tu2_1_1_1_1 hd_h_ml302.tu2_1_1_2_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">None</td><td headers="hd_h_ml302.tu2_1_1_1_2 hd_h_ml302.tu2_1_1_2_9 hd_h_ml302.tu2_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">1.563</td><td headers="hd_h_ml302.tu2_1_1_1_2 hd_h_ml302.tu2_1_1_2_9 hd_h_ml302.tu2_1_1_3_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_1_1_2 hd_h_ml302.tu2_1_1_2_10 hd_h_ml302.tu2_1_1_3_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0.781</td><td headers="hd_h_ml302.tu2_1_1_1_2 hd_h_ml302.tu2_1_1_2_10 hd_h_ml302.tu2_1_1_3_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">16X</td><td headers="hd_h_ml302.tu2_1_1_1_2 hd_h_ml302.tu2_1_1_2_11 hd_h_ml302.tu2_1_1_3_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">>50</td><td headers="hd_h_ml302.tu2_1_1_1_2 hd_h_ml302.tu2_1_1_2_11 hd_h_ml302.tu2_1_1_3_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_1_1_2 hd_h_ml302.tu2_1_1_2_12 hd_h_ml302.tu2_1_1_3_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">>50</td><td headers="hd_h_ml302.tu2_1_1_1_2 hd_h_ml302.tu2_1_1_2_12 hd_h_ml302.tu2_1_1_3_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_1_1_2 hd_h_ml302.tu2_1_1_2_13 hd_h_ml302.tu2_1_1_3_9" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">>50</td><td headers="hd_h_ml302.tu2_1_1_1_2 hd_h_ml302.tu2_1_1_2_13 hd_h_ml302.tu2_1_1_3_10" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_1_1_2 hd_h_ml302.tu2_1_1_2_14 hd_h_ml302.tu2_1_1_3_11" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">3.125</td><td headers="hd_h_ml302.tu2_1_1_1_2 hd_h_ml302.tu2_1_1_2_14 hd_h_ml302.tu2_1_1_3_12" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_1_1_3 hd_h_ml302.tu2_1_1_2_15 hd_h_ml302.tu2_1_1_3_13" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_1_1_3 hd_h_ml302.tu2_1_1_2_16 hd_h_ml302.tu2_1_1_3_14" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_1_1_3 hd_h_ml302.tu2_1_1_2_17 hd_h_ml302.tu2_1_1_3_15" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_1_1_3 hd_h_ml302.tu2_1_1_2_18 hd_h_ml302.tu2_1_1_3_16" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_1_1_3 hd_h_ml302.tu2_1_1_2_19 hd_h_ml302.tu2_1_1_3_17" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_1_1_3 hd_h_ml302.tu2_1_1_2_19 hd_h_ml302.tu2_1_1_3_18" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_1_1_3 hd_h_ml302.tu2_1_1_2_20 hd_h_ml302.tu2_1_1_3_19" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_1_1_3 hd_h_ml302.tu2_1_1_2_20 hd_h_ml302.tu2_1_1_3_20" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td></tr><tr><td headers="hd_h_ml302.tu2_1_1_1_1 hd_h_ml302.tu2_1_1_2_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Analog 2</td><td headers="hd_h_ml302.tu2_1_1_1_1 hd_h_ml302.tu2_1_1_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-03000002704-1</td><td headers="hd_h_ml302.tu2_1_1_1_1 hd_h_ml302.tu2_1_1_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">
|
||
<div class="graphic"><img src="/books/NBK143563/bin/ml302fu4.jpg" alt="Image ml302fu4.jpg" /></div></td><td headers="hd_h_ml302.tu2_1_1_1_1 hd_h_ml302.tu2_1_1_2_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">54579799</td><td headers="hd_h_ml302.tu2_1_1_1_1 hd_h_ml302.tu2_1_1_2_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/131269026" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">131269026</a></td><td headers="hd_h_ml302.tu2_1_1_1_1 hd_h_ml302.tu2_1_1_2_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">003940493</td><td headers="hd_h_ml302.tu2_1_1_1_1 hd_h_ml302.tu2_1_1_2_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">TSRI</td><td headers="hd_h_ml302.tu2_1_1_1_1 hd_h_ml302.tu2_1_1_2_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">None</td><td headers="hd_h_ml302.tu2_1_1_1_2 hd_h_ml302.tu2_1_1_2_9 hd_h_ml302.tu2_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">12.5</td><td headers="hd_h_ml302.tu2_1_1_1_2 hd_h_ml302.tu2_1_1_2_9 hd_h_ml302.tu2_1_1_3_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_1_1_2 hd_h_ml302.tu2_1_1_2_10 hd_h_ml302.tu2_1_1_3_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0.781</td><td headers="hd_h_ml302.tu2_1_1_1_2 hd_h_ml302.tu2_1_1_2_10 hd_h_ml302.tu2_1_1_3_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">32X</td><td headers="hd_h_ml302.tu2_1_1_1_2 hd_h_ml302.tu2_1_1_2_11 hd_h_ml302.tu2_1_1_3_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">>50</td><td headers="hd_h_ml302.tu2_1_1_1_2 hd_h_ml302.tu2_1_1_2_11 hd_h_ml302.tu2_1_1_3_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">2X</td><td headers="hd_h_ml302.tu2_1_1_1_2 hd_h_ml302.tu2_1_1_2_12 hd_h_ml302.tu2_1_1_3_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">>50</td><td headers="hd_h_ml302.tu2_1_1_1_2 hd_h_ml302.tu2_1_1_2_12 hd_h_ml302.tu2_1_1_3_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">2X</td><td headers="hd_h_ml302.tu2_1_1_1_2 hd_h_ml302.tu2_1_1_2_13 hd_h_ml302.tu2_1_1_3_9" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">>50</td><td headers="hd_h_ml302.tu2_1_1_1_2 hd_h_ml302.tu2_1_1_2_13 hd_h_ml302.tu2_1_1_3_10" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_1_1_2 hd_h_ml302.tu2_1_1_2_14 hd_h_ml302.tu2_1_1_3_11" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">25</td><td headers="hd_h_ml302.tu2_1_1_1_2 hd_h_ml302.tu2_1_1_2_14 hd_h_ml302.tu2_1_1_3_12" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_1_1_3 hd_h_ml302.tu2_1_1_2_15 hd_h_ml302.tu2_1_1_3_13" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_1_1_3 hd_h_ml302.tu2_1_1_2_16 hd_h_ml302.tu2_1_1_3_14" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_1_1_3 hd_h_ml302.tu2_1_1_2_17 hd_h_ml302.tu2_1_1_3_15" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_1_1_3 hd_h_ml302.tu2_1_1_2_18 hd_h_ml302.tu2_1_1_3_16" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_1_1_3 hd_h_ml302.tu2_1_1_2_19 hd_h_ml302.tu2_1_1_3_17" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_1_1_3 hd_h_ml302.tu2_1_1_2_19 hd_h_ml302.tu2_1_1_3_18" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_1_1_3 hd_h_ml302.tu2_1_1_2_20 hd_h_ml302.tu2_1_1_3_19" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_1_1_3 hd_h_ml302.tu2_1_1_2_20 hd_h_ml302.tu2_1_1_3_20" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td></tr><tr><td headers="hd_h_ml302.tu2_1_1_1_1 hd_h_ml302.tu2_1_1_2_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Analog 3</td><td headers="hd_h_ml302.tu2_1_1_1_1 hd_h_ml302.tu2_1_1_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-03000002705-1</td><td headers="hd_h_ml302.tu2_1_1_1_1 hd_h_ml302.tu2_1_1_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">
|
||
<div class="graphic"><img src="/books/NBK143563/bin/ml302fu5.jpg" alt="Image ml302fu5.jpg" /></div></td><td headers="hd_h_ml302.tu2_1_1_1_1 hd_h_ml302.tu2_1_1_2_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">54579797</td><td headers="hd_h_ml302.tu2_1_1_1_1 hd_h_ml302.tu2_1_1_2_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/131269027" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">131269027</a></td><td headers="hd_h_ml302.tu2_1_1_1_1 hd_h_ml302.tu2_1_1_2_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_1_1_1 hd_h_ml302.tu2_1_1_2_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">TSRI</td><td headers="hd_h_ml302.tu2_1_1_1_1 hd_h_ml302.tu2_1_1_2_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">None</td><td headers="hd_h_ml302.tu2_1_1_1_2 hd_h_ml302.tu2_1_1_2_9 hd_h_ml302.tu2_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">6.25</td><td headers="hd_h_ml302.tu2_1_1_1_2 hd_h_ml302.tu2_1_1_2_9 hd_h_ml302.tu2_1_1_3_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_1_1_2 hd_h_ml302.tu2_1_1_2_10 hd_h_ml302.tu2_1_1_3_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">1.563</td><td headers="hd_h_ml302.tu2_1_1_1_2 hd_h_ml302.tu2_1_1_2_10 hd_h_ml302.tu2_1_1_3_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">16X</td><td headers="hd_h_ml302.tu2_1_1_1_2 hd_h_ml302.tu2_1_1_2_11 hd_h_ml302.tu2_1_1_3_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">>50</td><td headers="hd_h_ml302.tu2_1_1_1_2 hd_h_ml302.tu2_1_1_2_11 hd_h_ml302.tu2_1_1_3_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_1_1_2 hd_h_ml302.tu2_1_1_2_12 hd_h_ml302.tu2_1_1_3_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">50</td><td headers="hd_h_ml302.tu2_1_1_1_2 hd_h_ml302.tu2_1_1_2_12 hd_h_ml302.tu2_1_1_3_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">4X</td><td headers="hd_h_ml302.tu2_1_1_1_2 hd_h_ml302.tu2_1_1_2_13 hd_h_ml302.tu2_1_1_3_9" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">>50</td><td headers="hd_h_ml302.tu2_1_1_1_2 hd_h_ml302.tu2_1_1_2_13 hd_h_ml302.tu2_1_1_3_10" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_1_1_2 hd_h_ml302.tu2_1_1_2_14 hd_h_ml302.tu2_1_1_3_11" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0.781</td><td headers="hd_h_ml302.tu2_1_1_1_2 hd_h_ml302.tu2_1_1_2_14 hd_h_ml302.tu2_1_1_3_12" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">8X</td><td headers="hd_h_ml302.tu2_1_1_1_3 hd_h_ml302.tu2_1_1_2_15 hd_h_ml302.tu2_1_1_3_13" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_1_1_3 hd_h_ml302.tu2_1_1_2_16 hd_h_ml302.tu2_1_1_3_14" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_1_1_3 hd_h_ml302.tu2_1_1_2_17 hd_h_ml302.tu2_1_1_3_15" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_1_1_3 hd_h_ml302.tu2_1_1_2_18 hd_h_ml302.tu2_1_1_3_16" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_1_1_3 hd_h_ml302.tu2_1_1_2_19 hd_h_ml302.tu2_1_1_3_17" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_1_1_3 hd_h_ml302.tu2_1_1_2_19 hd_h_ml302.tu2_1_1_3_18" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_1_1_3 hd_h_ml302.tu2_1_1_2_20 hd_h_ml302.tu2_1_1_3_19" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_1_1_3 hd_h_ml302.tu2_1_1_2_20 hd_h_ml302.tu2_1_1_3_20" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td></tr><tr><td headers="hd_h_ml302.tu2_1_1_1_1 hd_h_ml302.tu2_1_1_2_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Analog 3</td><td headers="hd_h_ml302.tu2_1_1_1_1 hd_h_ml302.tu2_1_1_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-03000002705-2</td><td headers="hd_h_ml302.tu2_1_1_1_1 hd_h_ml302.tu2_1_1_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">
|
||
<div class="graphic"><img src="/books/NBK143563/bin/ml302fu5.jpg" alt="Image ml302fu5.jpg" /></div></td><td headers="hd_h_ml302.tu2_1_1_1_1 hd_h_ml302.tu2_1_1_2_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">54579797</td><td headers="hd_h_ml302.tu2_1_1_1_1 hd_h_ml302.tu2_1_1_2_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/134220673" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">134220673</a></td><td headers="hd_h_ml302.tu2_1_1_1_1 hd_h_ml302.tu2_1_1_2_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">003940494</td><td headers="hd_h_ml302.tu2_1_1_1_1 hd_h_ml302.tu2_1_1_2_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">TSRI</td><td headers="hd_h_ml302.tu2_1_1_1_1 hd_h_ml302.tu2_1_1_2_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">None</td><td headers="hd_h_ml302.tu2_1_1_1_2 hd_h_ml302.tu2_1_1_2_9 hd_h_ml302.tu2_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_1_1_2 hd_h_ml302.tu2_1_1_2_9 hd_h_ml302.tu2_1_1_3_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_1_1_2 hd_h_ml302.tu2_1_1_2_10 hd_h_ml302.tu2_1_1_3_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0.781</td><td headers="hd_h_ml302.tu2_1_1_1_2 hd_h_ml302.tu2_1_1_2_10 hd_h_ml302.tu2_1_1_3_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">32X</td><td headers="hd_h_ml302.tu2_1_1_1_2 hd_h_ml302.tu2_1_1_2_11 hd_h_ml302.tu2_1_1_3_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_1_1_2 hd_h_ml302.tu2_1_1_2_11 hd_h_ml302.tu2_1_1_3_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_1_1_2 hd_h_ml302.tu2_1_1_2_12 hd_h_ml302.tu2_1_1_3_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_1_1_2 hd_h_ml302.tu2_1_1_2_12 hd_h_ml302.tu2_1_1_3_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_1_1_2 hd_h_ml302.tu2_1_1_2_13 hd_h_ml302.tu2_1_1_3_9" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_1_1_2 hd_h_ml302.tu2_1_1_2_13 hd_h_ml302.tu2_1_1_3_10" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_1_1_2 hd_h_ml302.tu2_1_1_2_14 hd_h_ml302.tu2_1_1_3_11" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_1_1_2 hd_h_ml302.tu2_1_1_2_14 hd_h_ml302.tu2_1_1_3_12" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_1_1_3 hd_h_ml302.tu2_1_1_2_15 hd_h_ml302.tu2_1_1_3_13" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_1_1_3 hd_h_ml302.tu2_1_1_2_16 hd_h_ml302.tu2_1_1_3_14" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_1_1_3 hd_h_ml302.tu2_1_1_2_17 hd_h_ml302.tu2_1_1_3_15" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_1_1_3 hd_h_ml302.tu2_1_1_2_18 hd_h_ml302.tu2_1_1_3_16" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_1_1_3 hd_h_ml302.tu2_1_1_2_19 hd_h_ml302.tu2_1_1_3_17" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_1_1_3 hd_h_ml302.tu2_1_1_2_19 hd_h_ml302.tu2_1_1_3_18" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_1_1_3 hd_h_ml302.tu2_1_1_2_20 hd_h_ml302.tu2_1_1_3_19" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_1_1_3 hd_h_ml302.tu2_1_1_2_20 hd_h_ml302.tu2_1_1_3_20" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td></tr><tr><td headers="hd_h_ml302.tu2_1_1_1_1 hd_h_ml302.tu2_1_1_2_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Analog 4</td><td headers="hd_h_ml302.tu2_1_1_1_1 hd_h_ml302.tu2_1_1_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-03000002672-1</td><td headers="hd_h_ml302.tu2_1_1_1_1 hd_h_ml302.tu2_1_1_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">
|
||
<div class="graphic"><img src="/books/NBK143563/bin/ml302fu6.jpg" alt="Image ml302fu6.jpg" /></div></td><td headers="hd_h_ml302.tu2_1_1_1_1 hd_h_ml302.tu2_1_1_2_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">53495082</td><td headers="hd_h_ml302.tu2_1_1_1_1 hd_h_ml302.tu2_1_1_2_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/126723253" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">126723253</a></td><td headers="hd_h_ml302.tu2_1_1_1_1 hd_h_ml302.tu2_1_1_2_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_1_1_1 hd_h_ml302.tu2_1_1_2_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">TSRI</td><td headers="hd_h_ml302.tu2_1_1_1_1 hd_h_ml302.tu2_1_1_2_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">None</td><td headers="hd_h_ml302.tu2_1_1_1_2 hd_h_ml302.tu2_1_1_2_9 hd_h_ml302.tu2_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">3.125</td><td headers="hd_h_ml302.tu2_1_1_1_2 hd_h_ml302.tu2_1_1_2_9 hd_h_ml302.tu2_1_1_3_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_1_1_2 hd_h_ml302.tu2_1_1_2_10 hd_h_ml302.tu2_1_1_3_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">1.563</td><td headers="hd_h_ml302.tu2_1_1_1_2 hd_h_ml302.tu2_1_1_2_10 hd_h_ml302.tu2_1_1_3_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">16X</td><td headers="hd_h_ml302.tu2_1_1_1_2 hd_h_ml302.tu2_1_1_2_11 hd_h_ml302.tu2_1_1_3_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">>50</td><td headers="hd_h_ml302.tu2_1_1_1_2 hd_h_ml302.tu2_1_1_2_11 hd_h_ml302.tu2_1_1_3_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_1_1_2 hd_h_ml302.tu2_1_1_2_12 hd_h_ml302.tu2_1_1_3_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">>50</td><td headers="hd_h_ml302.tu2_1_1_1_2 hd_h_ml302.tu2_1_1_2_12 hd_h_ml302.tu2_1_1_3_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_1_1_2 hd_h_ml302.tu2_1_1_2_13 hd_h_ml302.tu2_1_1_3_9" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">>50</td><td headers="hd_h_ml302.tu2_1_1_1_2 hd_h_ml302.tu2_1_1_2_13 hd_h_ml302.tu2_1_1_3_10" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_1_1_2 hd_h_ml302.tu2_1_1_2_14 hd_h_ml302.tu2_1_1_3_11" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0.781</td><td headers="hd_h_ml302.tu2_1_1_1_2 hd_h_ml302.tu2_1_1_2_14 hd_h_ml302.tu2_1_1_3_12" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_1_1_3 hd_h_ml302.tu2_1_1_2_15 hd_h_ml302.tu2_1_1_3_13" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_1_1_3 hd_h_ml302.tu2_1_1_2_16 hd_h_ml302.tu2_1_1_3_14" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_1_1_3 hd_h_ml302.tu2_1_1_2_17 hd_h_ml302.tu2_1_1_3_15" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_1_1_3 hd_h_ml302.tu2_1_1_2_18 hd_h_ml302.tu2_1_1_3_16" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_1_1_3 hd_h_ml302.tu2_1_1_2_19 hd_h_ml302.tu2_1_1_3_17" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_1_1_3 hd_h_ml302.tu2_1_1_2_19 hd_h_ml302.tu2_1_1_3_18" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_1_1_3 hd_h_ml302.tu2_1_1_2_20 hd_h_ml302.tu2_1_1_3_19" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_1_1_3 hd_h_ml302.tu2_1_1_2_20 hd_h_ml302.tu2_1_1_3_20" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td></tr><tr><td headers="hd_h_ml302.tu2_1_1_1_1 hd_h_ml302.tu2_1_1_2_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Analog 4</td><td headers="hd_h_ml302.tu2_1_1_1_1 hd_h_ml302.tu2_1_1_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-03000002672-2</td><td headers="hd_h_ml302.tu2_1_1_1_1 hd_h_ml302.tu2_1_1_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">
|
||
<div class="graphic"><img src="/books/NBK143563/bin/ml302fu6.jpg" alt="Image ml302fu6.jpg" /></div></td><td headers="hd_h_ml302.tu2_1_1_1_1 hd_h_ml302.tu2_1_1_2_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">53495082</td><td headers="hd_h_ml302.tu2_1_1_1_1 hd_h_ml302.tu2_1_1_2_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/134220674" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">134220674</a></td><td headers="hd_h_ml302.tu2_1_1_1_1 hd_h_ml302.tu2_1_1_2_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">003940495</td><td headers="hd_h_ml302.tu2_1_1_1_1 hd_h_ml302.tu2_1_1_2_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">TSRI</td><td headers="hd_h_ml302.tu2_1_1_1_1 hd_h_ml302.tu2_1_1_2_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">None</td><td headers="hd_h_ml302.tu2_1_1_1_2 hd_h_ml302.tu2_1_1_2_9 hd_h_ml302.tu2_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_1_1_2 hd_h_ml302.tu2_1_1_2_9 hd_h_ml302.tu2_1_1_3_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_1_1_2 hd_h_ml302.tu2_1_1_2_10 hd_h_ml302.tu2_1_1_3_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">1.563</td><td headers="hd_h_ml302.tu2_1_1_1_2 hd_h_ml302.tu2_1_1_2_10 hd_h_ml302.tu2_1_1_3_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">32X</td><td headers="hd_h_ml302.tu2_1_1_1_2 hd_h_ml302.tu2_1_1_2_11 hd_h_ml302.tu2_1_1_3_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_1_1_2 hd_h_ml302.tu2_1_1_2_11 hd_h_ml302.tu2_1_1_3_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_1_1_2 hd_h_ml302.tu2_1_1_2_12 hd_h_ml302.tu2_1_1_3_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_1_1_2 hd_h_ml302.tu2_1_1_2_12 hd_h_ml302.tu2_1_1_3_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_1_1_2 hd_h_ml302.tu2_1_1_2_13 hd_h_ml302.tu2_1_1_3_9" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_1_1_2 hd_h_ml302.tu2_1_1_2_13 hd_h_ml302.tu2_1_1_3_10" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_1_1_2 hd_h_ml302.tu2_1_1_2_14 hd_h_ml302.tu2_1_1_3_11" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_1_1_2 hd_h_ml302.tu2_1_1_2_14 hd_h_ml302.tu2_1_1_3_12" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_1_1_3 hd_h_ml302.tu2_1_1_2_15 hd_h_ml302.tu2_1_1_3_13" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_1_1_3 hd_h_ml302.tu2_1_1_2_16 hd_h_ml302.tu2_1_1_3_14" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_1_1_3 hd_h_ml302.tu2_1_1_2_17 hd_h_ml302.tu2_1_1_3_15" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_1_1_3 hd_h_ml302.tu2_1_1_2_18 hd_h_ml302.tu2_1_1_3_16" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_1_1_3 hd_h_ml302.tu2_1_1_2_19 hd_h_ml302.tu2_1_1_3_17" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_1_1_3 hd_h_ml302.tu2_1_1_2_19 hd_h_ml302.tu2_1_1_3_18" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_1_1_3 hd_h_ml302.tu2_1_1_2_20 hd_h_ml302.tu2_1_1_3_19" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_1_1_3 hd_h_ml302.tu2_1_1_2_20 hd_h_ml302.tu2_1_1_3_20" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td></tr><tr><td headers="hd_h_ml302.tu2_1_1_1_1 hd_h_ml302.tu2_1_1_2_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Analog 5</td><td headers="hd_h_ml302.tu2_1_1_1_1 hd_h_ml302.tu2_1_1_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-03000002594-1</td><td headers="hd_h_ml302.tu2_1_1_1_1 hd_h_ml302.tu2_1_1_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">
|
||
<div class="graphic"><img src="/books/NBK143563/bin/ml302fu7.jpg" alt="Image ml302fu7.jpg" /></div></td><td headers="hd_h_ml302.tu2_1_1_1_1 hd_h_ml302.tu2_1_1_2_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">53384679</td><td headers="hd_h_ml302.tu2_1_1_1_1 hd_h_ml302.tu2_1_1_2_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/125311278" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">125311278</a></td><td headers="hd_h_ml302.tu2_1_1_1_1 hd_h_ml302.tu2_1_1_2_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_1_1_1 hd_h_ml302.tu2_1_1_2_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">TSRI</td><td headers="hd_h_ml302.tu2_1_1_1_1 hd_h_ml302.tu2_1_1_2_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">None</td><td headers="hd_h_ml302.tu2_1_1_1_2 hd_h_ml302.tu2_1_1_2_9 hd_h_ml302.tu2_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">3.125</td><td headers="hd_h_ml302.tu2_1_1_1_2 hd_h_ml302.tu2_1_1_2_9 hd_h_ml302.tu2_1_1_3_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">8X</td><td headers="hd_h_ml302.tu2_1_1_1_2 hd_h_ml302.tu2_1_1_2_10 hd_h_ml302.tu2_1_1_3_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">1.563</td><td headers="hd_h_ml302.tu2_1_1_1_2 hd_h_ml302.tu2_1_1_2_10 hd_h_ml302.tu2_1_1_3_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">16X</td><td headers="hd_h_ml302.tu2_1_1_1_2 hd_h_ml302.tu2_1_1_2_11 hd_h_ml302.tu2_1_1_3_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">>50</td><td headers="hd_h_ml302.tu2_1_1_1_2 hd_h_ml302.tu2_1_1_2_11 hd_h_ml302.tu2_1_1_3_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_1_1_2 hd_h_ml302.tu2_1_1_2_12 hd_h_ml302.tu2_1_1_3_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">>50</td><td headers="hd_h_ml302.tu2_1_1_1_2 hd_h_ml302.tu2_1_1_2_12 hd_h_ml302.tu2_1_1_3_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Achievs 2X</td><td headers="hd_h_ml302.tu2_1_1_1_2 hd_h_ml302.tu2_1_1_2_13 hd_h_ml302.tu2_1_1_3_9" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">>50</td><td headers="hd_h_ml302.tu2_1_1_1_2 hd_h_ml302.tu2_1_1_2_13 hd_h_ml302.tu2_1_1_3_10" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_1_1_2 hd_h_ml302.tu2_1_1_2_14 hd_h_ml302.tu2_1_1_3_11" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">1.563</td><td headers="hd_h_ml302.tu2_1_1_1_2 hd_h_ml302.tu2_1_1_2_14 hd_h_ml302.tu2_1_1_3_12" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_1_1_3 hd_h_ml302.tu2_1_1_2_15 hd_h_ml302.tu2_1_1_3_13" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_1_1_3 hd_h_ml302.tu2_1_1_2_16 hd_h_ml302.tu2_1_1_3_14" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_1_1_3 hd_h_ml302.tu2_1_1_2_17 hd_h_ml302.tu2_1_1_3_15" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_1_1_3 hd_h_ml302.tu2_1_1_2_18 hd_h_ml302.tu2_1_1_3_16" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_1_1_3 hd_h_ml302.tu2_1_1_2_19 hd_h_ml302.tu2_1_1_3_17" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_1_1_3 hd_h_ml302.tu2_1_1_2_19 hd_h_ml302.tu2_1_1_3_18" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_1_1_3 hd_h_ml302.tu2_1_1_2_20 hd_h_ml302.tu2_1_1_3_19" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_1_1_3 hd_h_ml302.tu2_1_1_2_20 hd_h_ml302.tu2_1_1_3_20" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td></tr><tr><td headers="hd_h_ml302.tu2_1_1_1_1 hd_h_ml302.tu2_1_1_2_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Analog 5</td><td headers="hd_h_ml302.tu2_1_1_1_1 hd_h_ml302.tu2_1_1_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-03000002594-2</td><td headers="hd_h_ml302.tu2_1_1_1_1 hd_h_ml302.tu2_1_1_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">
|
||
<div class="graphic"><img src="/books/NBK143563/bin/ml302fu7.jpg" alt="Image ml302fu7.jpg" /></div></td><td headers="hd_h_ml302.tu2_1_1_1_1 hd_h_ml302.tu2_1_1_2_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">53384679</td><td headers="hd_h_ml302.tu2_1_1_1_1 hd_h_ml302.tu2_1_1_2_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/134220676" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">134220676</a></td><td headers="hd_h_ml302.tu2_1_1_1_1 hd_h_ml302.tu2_1_1_2_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">003940496</td><td headers="hd_h_ml302.tu2_1_1_1_1 hd_h_ml302.tu2_1_1_2_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">TSRI</td><td headers="hd_h_ml302.tu2_1_1_1_1 hd_h_ml302.tu2_1_1_2_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">None</td><td headers="hd_h_ml302.tu2_1_1_1_2 hd_h_ml302.tu2_1_1_2_9 hd_h_ml302.tu2_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_1_1_2 hd_h_ml302.tu2_1_1_2_9 hd_h_ml302.tu2_1_1_3_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_1_1_2 hd_h_ml302.tu2_1_1_2_10 hd_h_ml302.tu2_1_1_3_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0.781</td><td headers="hd_h_ml302.tu2_1_1_1_2 hd_h_ml302.tu2_1_1_2_10 hd_h_ml302.tu2_1_1_3_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">16X</td><td headers="hd_h_ml302.tu2_1_1_1_2 hd_h_ml302.tu2_1_1_2_11 hd_h_ml302.tu2_1_1_3_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_1_1_2 hd_h_ml302.tu2_1_1_2_11 hd_h_ml302.tu2_1_1_3_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_1_1_2 hd_h_ml302.tu2_1_1_2_12 hd_h_ml302.tu2_1_1_3_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_1_1_2 hd_h_ml302.tu2_1_1_2_12 hd_h_ml302.tu2_1_1_3_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_1_1_2 hd_h_ml302.tu2_1_1_2_13 hd_h_ml302.tu2_1_1_3_9" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_1_1_2 hd_h_ml302.tu2_1_1_2_13 hd_h_ml302.tu2_1_1_3_10" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_1_1_2 hd_h_ml302.tu2_1_1_2_14 hd_h_ml302.tu2_1_1_3_11" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_1_1_2 hd_h_ml302.tu2_1_1_2_14 hd_h_ml302.tu2_1_1_3_12" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_1_1_3 hd_h_ml302.tu2_1_1_2_15 hd_h_ml302.tu2_1_1_3_13" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_1_1_3 hd_h_ml302.tu2_1_1_2_16 hd_h_ml302.tu2_1_1_3_14" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_1_1_3 hd_h_ml302.tu2_1_1_2_17 hd_h_ml302.tu2_1_1_3_15" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_1_1_3 hd_h_ml302.tu2_1_1_2_18 hd_h_ml302.tu2_1_1_3_16" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_1_1_3 hd_h_ml302.tu2_1_1_2_19 hd_h_ml302.tu2_1_1_3_17" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_1_1_3 hd_h_ml302.tu2_1_1_2_19 hd_h_ml302.tu2_1_1_3_18" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_1_1_3 hd_h_ml302.tu2_1_1_2_20 hd_h_ml302.tu2_1_1_3_19" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_1_1_3 hd_h_ml302.tu2_1_1_2_20 hd_h_ml302.tu2_1_1_3_20" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td></tr></tbody></table><table><thead><tr><th id="hd_h_ml302.tu2_1_2_1_1" colspan="8" rowspan="1" style="text-align:center;vertical-align:middle;">Compound Information</th><th id="hd_h_ml302.tu2_1_2_1_2" colspan="10" rowspan="1" style="text-align:center;vertical-align:middle;">Bioassays</th><th id="hd_h_ml302.tu2_1_2_1_3" colspan="3" rowspan="1" style="text-align:center;vertical-align:middle;">Biochemical Assays</th></tr><tr><th headers="hd_h_ml302.tu2_1_2_1_1 hd_h_ml302.tu2_1_2_2_1" id="hd_h_ml302.tu2_1_2_2_1" rowspan="2" colspan="1" style="text-align:center;vertical-align:middle;">Compound</th><th headers="hd_h_ml302.tu2_1_2_1_1 hd_h_ml302.tu2_1_2_2_2" id="hd_h_ml302.tu2_1_2_2_2" rowspan="2" colspan="1" style="text-align:center;vertical-align:middle;">SR-Number</th><th headers="hd_h_ml302.tu2_1_2_1_1 hd_h_ml302.tu2_1_2_2_3" id="hd_h_ml302.tu2_1_2_2_3" rowspan="2" colspan="1" style="text-align:center;vertical-align:middle;">Structure</th><th headers="hd_h_ml302.tu2_1_2_1_1 hd_h_ml302.tu2_1_2_2_4" id="hd_h_ml302.tu2_1_2_2_4" rowspan="2" colspan="1" style="text-align:center;vertical-align:middle;">CID</th><th headers="hd_h_ml302.tu2_1_2_1_1 hd_h_ml302.tu2_1_2_2_5" id="hd_h_ml302.tu2_1_2_2_5" rowspan="2" colspan="1" style="text-align:center;vertical-align:middle;">SID</th><th headers="hd_h_ml302.tu2_1_2_1_1 hd_h_ml302.tu2_1_2_2_6" id="hd_h_ml302.tu2_1_2_2_6" rowspan="2" colspan="1" style="text-align:center;vertical-align:middle;">MLS</th><th headers="hd_h_ml302.tu2_1_2_1_1 hd_h_ml302.tu2_1_2_2_7" id="hd_h_ml302.tu2_1_2_2_7" rowspan="2" colspan="1" style="text-align:center;vertical-align:middle;">Vendor</th><th headers="hd_h_ml302.tu2_1_2_1_1 hd_h_ml302.tu2_1_2_2_8" id="hd_h_ml302.tu2_1_2_2_8" rowspan="2" colspan="1" style="text-align:center;vertical-align:middle;">Vendor Catalog ID</th><th headers="hd_h_ml302.tu2_1_2_1_2" id="hd_h_ml302.tu2_1_2_2_9" colspan="2" rowspan="1" style="text-align:center;vertical-align:middle;">BL21 (VIM-2)</th><th headers="hd_h_ml302.tu2_1_2_1_2" id="hd_h_ml302.tu2_1_2_2_10" colspan="2" rowspan="1" style="text-align:center;vertical-align:middle;">YMC07/B3323 (VIM-2)</th><th headers="hd_h_ml302.tu2_1_2_1_2" id="hd_h_ml302.tu2_1_2_2_11" colspan="2" rowspan="1" style="text-align:center;vertical-align:middle;">BAA-2146 (NDM-1)</th><th headers="hd_h_ml302.tu2_1_2_1_2" id="hd_h_ml302.tu2_1_2_2_12" colspan="2" rowspan="1" style="text-align:center;vertical-align:middle;">PA641 (VIM-2)</th><th headers="hd_h_ml302.tu2_1_2_1_2" id="hd_h_ml302.tu2_1_2_2_13" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">KN20</th><th headers="hd_h_ml302.tu2_1_2_1_2" id="hd_h_ml302.tu2_1_2_2_14" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">BL21</th><th headers="hd_h_ml302.tu2_1_2_1_3" id="hd_h_ml302.tu2_1_2_2_15" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">VIM-2</th><th headers="hd_h_ml302.tu2_1_2_1_3" id="hd_h_ml302.tu2_1_2_2_16" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">IMP-1</th><th headers="hd_h_ml302.tu2_1_2_1_3" id="hd_h_ml302.tu2_1_2_2_17" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">VIM-2 Ki</th></tr><tr><th headers="hd_h_ml302.tu2_1_2_1_2 hd_h_ml302.tu2_1_2_2_9" id="hd_h_ml302.tu2_1_2_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">MIC 4× (μM)</th><th headers="hd_h_ml302.tu2_1_2_1_2 hd_h_ml302.tu2_1_2_2_9" id="hd_h_ml302.tu2_1_2_3_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Imipenem Potentiation</th><th headers="hd_h_ml302.tu2_1_2_1_2 hd_h_ml302.tu2_1_2_2_10" id="hd_h_ml302.tu2_1_2_3_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">MIC 4× (μM)</th><th headers="hd_h_ml302.tu2_1_2_1_2 hd_h_ml302.tu2_1_2_2_10" id="hd_h_ml302.tu2_1_2_3_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Imipenem Potentiation</th><th headers="hd_h_ml302.tu2_1_2_1_2 hd_h_ml302.tu2_1_2_2_11" id="hd_h_ml302.tu2_1_2_3_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">MIC 4× (μM)</th><th headers="hd_h_ml302.tu2_1_2_1_2 hd_h_ml302.tu2_1_2_2_11" id="hd_h_ml302.tu2_1_2_3_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Imipenem Potentiation</th><th headers="hd_h_ml302.tu2_1_2_1_2 hd_h_ml302.tu2_1_2_2_12" id="hd_h_ml302.tu2_1_2_3_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">MIC 4× (μM)</th><th headers="hd_h_ml302.tu2_1_2_1_2 hd_h_ml302.tu2_1_2_2_12" id="hd_h_ml302.tu2_1_2_3_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Imipenem Potentiation</th><th headers="hd_h_ml302.tu2_1_2_1_2 hd_h_ml302.tu2_1_2_2_13" id="hd_h_ml302.tu2_1_2_3_9" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">MIC 4× (μM)</th><th headers="hd_h_ml302.tu2_1_2_1_2 hd_h_ml302.tu2_1_2_2_14" id="hd_h_ml302.tu2_1_2_3_10" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">MIC 4× (μM)</th><th headers="hd_h_ml302.tu2_1_2_1_3 hd_h_ml302.tu2_1_2_2_15" id="hd_h_ml302.tu2_1_2_3_11" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">IC50 (uM)</th><th headers="hd_h_ml302.tu2_1_2_1_3 hd_h_ml302.tu2_1_2_2_16" id="hd_h_ml302.tu2_1_2_3_12" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">IC50 (uM)</th><th headers="hd_h_ml302.tu2_1_2_1_3 hd_h_ml302.tu2_1_2_2_17" id="hd_h_ml302.tu2_1_2_3_13" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Ki (nM)</th></tr></thead><tbody><tr><td headers="hd_h_ml302.tu2_1_2_1_1 hd_h_ml302.tu2_1_2_2_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Analog 6</td><td headers="hd_h_ml302.tu2_1_2_1_1 hd_h_ml302.tu2_1_2_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-03000002441-1</td><td headers="hd_h_ml302.tu2_1_2_1_1 hd_h_ml302.tu2_1_2_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">
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<div class="graphic"><img src="/books/NBK143563/bin/ml302fu8.jpg" alt="Image ml302fu8.jpg" /></div></td><td headers="hd_h_ml302.tu2_1_2_1_1 hd_h_ml302.tu2_1_2_2_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">53308605</td><td headers="hd_h_ml302.tu2_1_2_1_1 hd_h_ml302.tu2_1_2_2_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/124767346" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">124767346</a></td><td headers="hd_h_ml302.tu2_1_2_1_1 hd_h_ml302.tu2_1_2_2_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_2_1_1 hd_h_ml302.tu2_1_2_2_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">TSRI</td><td headers="hd_h_ml302.tu2_1_2_1_1 hd_h_ml302.tu2_1_2_2_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">None</td><td headers="hd_h_ml302.tu2_1_2_1_2 hd_h_ml302.tu2_1_2_2_9 hd_h_ml302.tu2_1_2_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">12.5</td><td headers="hd_h_ml302.tu2_1_2_1_2 hd_h_ml302.tu2_1_2_2_9 hd_h_ml302.tu2_1_2_3_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">8X</td><td headers="hd_h_ml302.tu2_1_2_1_2 hd_h_ml302.tu2_1_2_2_10 hd_h_ml302.tu2_1_2_3_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">3.125</td><td headers="hd_h_ml302.tu2_1_2_1_2 hd_h_ml302.tu2_1_2_2_10 hd_h_ml302.tu2_1_2_3_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">32X</td><td headers="hd_h_ml302.tu2_1_2_1_2 hd_h_ml302.tu2_1_2_2_11 hd_h_ml302.tu2_1_2_3_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">>100</td><td headers="hd_h_ml302.tu2_1_2_1_2 hd_h_ml302.tu2_1_2_2_11 hd_h_ml302.tu2_1_2_3_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">2X</td><td headers="hd_h_ml302.tu2_1_2_1_2 hd_h_ml302.tu2_1_2_2_12 hd_h_ml302.tu2_1_2_3_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">>100</td><td headers="hd_h_ml302.tu2_1_2_1_2 hd_h_ml302.tu2_1_2_2_12 hd_h_ml302.tu2_1_2_3_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">2X</td><td headers="hd_h_ml302.tu2_1_2_1_2 hd_h_ml302.tu2_1_2_2_13 hd_h_ml302.tu2_1_2_3_9" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">>100</td><td headers="hd_h_ml302.tu2_1_2_1_2 hd_h_ml302.tu2_1_2_2_14 hd_h_ml302.tu2_1_2_3_10" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">3.125</td><td headers="hd_h_ml302.tu2_1_2_1_3 hd_h_ml302.tu2_1_2_2_15 hd_h_ml302.tu2_1_2_3_11" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_2_1_3 hd_h_ml302.tu2_1_2_2_16 hd_h_ml302.tu2_1_2_3_12" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_2_1_3 hd_h_ml302.tu2_1_2_2_17 hd_h_ml302.tu2_1_2_3_13" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td></tr><tr><td headers="hd_h_ml302.tu2_1_2_1_1 hd_h_ml302.tu2_1_2_2_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Analog 6 (resynthesized for submission to NIH)</td><td headers="hd_h_ml302.tu2_1_2_1_1 hd_h_ml302.tu2_1_2_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-03000002441-2</td><td headers="hd_h_ml302.tu2_1_2_1_1 hd_h_ml302.tu2_1_2_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">
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<div class="graphic"><img src="/books/NBK143563/bin/ml302fu8.jpg" alt="Image ml302fu8.jpg" /></div></td><td headers="hd_h_ml302.tu2_1_2_1_1 hd_h_ml302.tu2_1_2_2_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">53308605</td><td headers="hd_h_ml302.tu2_1_2_1_1 hd_h_ml302.tu2_1_2_2_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/134220675" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">134220675</a></td><td headers="hd_h_ml302.tu2_1_2_1_1 hd_h_ml302.tu2_1_2_2_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">003940497</td><td headers="hd_h_ml302.tu2_1_2_1_1 hd_h_ml302.tu2_1_2_2_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">TSRI</td><td headers="hd_h_ml302.tu2_1_2_1_1 hd_h_ml302.tu2_1_2_2_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">None</td><td headers="hd_h_ml302.tu2_1_2_1_2 hd_h_ml302.tu2_1_2_2_9 hd_h_ml302.tu2_1_2_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_2_1_2 hd_h_ml302.tu2_1_2_2_9 hd_h_ml302.tu2_1_2_3_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_2_1_2 hd_h_ml302.tu2_1_2_2_10 hd_h_ml302.tu2_1_2_3_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">3.125</td><td headers="hd_h_ml302.tu2_1_2_1_2 hd_h_ml302.tu2_1_2_2_10 hd_h_ml302.tu2_1_2_3_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">32X</td><td headers="hd_h_ml302.tu2_1_2_1_2 hd_h_ml302.tu2_1_2_2_11 hd_h_ml302.tu2_1_2_3_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_2_1_2 hd_h_ml302.tu2_1_2_2_11 hd_h_ml302.tu2_1_2_3_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_2_1_2 hd_h_ml302.tu2_1_2_2_12 hd_h_ml302.tu2_1_2_3_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_2_1_2 hd_h_ml302.tu2_1_2_2_12 hd_h_ml302.tu2_1_2_3_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_2_1_2 hd_h_ml302.tu2_1_2_2_13 hd_h_ml302.tu2_1_2_3_9" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_2_1_2 hd_h_ml302.tu2_1_2_2_14 hd_h_ml302.tu2_1_2_3_10" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_2_1_3 hd_h_ml302.tu2_1_2_2_15 hd_h_ml302.tu2_1_2_3_11" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_2_1_3 hd_h_ml302.tu2_1_2_2_16 hd_h_ml302.tu2_1_2_3_12" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_2_1_3 hd_h_ml302.tu2_1_2_2_17 hd_h_ml302.tu2_1_2_3_13" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td></tr><tr><td headers="hd_h_ml302.tu2_1_2_1_1 hd_h_ml302.tu2_1_2_2_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Analog 7 (Purchased)</td><td headers="hd_h_ml302.tu2_1_2_1_1 hd_h_ml302.tu2_1_2_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-01000216818-4</td><td headers="hd_h_ml302.tu2_1_2_1_1 hd_h_ml302.tu2_1_2_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">
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<div class="graphic"><img src="/books/NBK143563/bin/ml302fu9.jpg" alt="Image ml302fu9.jpg" /></div></td><td headers="hd_h_ml302.tu2_1_2_1_1 hd_h_ml302.tu2_1_2_2_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">1733268</td><td headers="hd_h_ml302.tu2_1_2_1_1 hd_h_ml302.tu2_1_2_2_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/135631809" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">135631809</a></td><td headers="hd_h_ml302.tu2_1_2_1_1 hd_h_ml302.tu2_1_2_2_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_2_1_1 hd_h_ml302.tu2_1_2_2_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ChemBridge</td><td headers="hd_h_ml302.tu2_1_2_1_1 hd_h_ml302.tu2_1_2_2_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">5680564</td><td headers="hd_h_ml302.tu2_1_2_1_2 hd_h_ml302.tu2_1_2_2_9 hd_h_ml302.tu2_1_2_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_2_1_2 hd_h_ml302.tu2_1_2_2_9 hd_h_ml302.tu2_1_2_3_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_2_1_2 hd_h_ml302.tu2_1_2_2_10 hd_h_ml302.tu2_1_2_3_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_2_1_2 hd_h_ml302.tu2_1_2_2_10 hd_h_ml302.tu2_1_2_3_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_2_1_2 hd_h_ml302.tu2_1_2_2_11 hd_h_ml302.tu2_1_2_3_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_2_1_2 hd_h_ml302.tu2_1_2_2_11 hd_h_ml302.tu2_1_2_3_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_2_1_2 hd_h_ml302.tu2_1_2_2_12 hd_h_ml302.tu2_1_2_3_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_2_1_2 hd_h_ml302.tu2_1_2_2_12 hd_h_ml302.tu2_1_2_3_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_2_1_2 hd_h_ml302.tu2_1_2_2_13 hd_h_ml302.tu2_1_2_3_9" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_2_1_2 hd_h_ml302.tu2_1_2_2_14 hd_h_ml302.tu2_1_2_3_10" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_2_1_3 hd_h_ml302.tu2_1_2_2_15 hd_h_ml302.tu2_1_2_3_11" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">4.55</td><td headers="hd_h_ml302.tu2_1_2_1_3 hd_h_ml302.tu2_1_2_2_16 hd_h_ml302.tu2_1_2_3_12" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_2_1_3 hd_h_ml302.tu2_1_2_2_17 hd_h_ml302.tu2_1_2_3_13" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">1.781 +/− 0.384</td></tr><tr><td headers="hd_h_ml302.tu2_1_2_1_1 hd_h_ml302.tu2_1_2_2_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Analog 7 (resynthesized)</td><td headers="hd_h_ml302.tu2_1_2_1_1 hd_h_ml302.tu2_1_2_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-01000216818-6</td><td headers="hd_h_ml302.tu2_1_2_1_1 hd_h_ml302.tu2_1_2_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">
|
||
<div class="graphic"><img src="/books/NBK143563/bin/ml302fu9.jpg" alt="Image ml302fu9.jpg" /></div></td><td headers="hd_h_ml302.tu2_1_2_1_1 hd_h_ml302.tu2_1_2_2_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">1733268</td><td headers="hd_h_ml302.tu2_1_2_1_1 hd_h_ml302.tu2_1_2_2_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/123083180" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">123083180</a></td><td headers="hd_h_ml302.tu2_1_2_1_1 hd_h_ml302.tu2_1_2_2_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_2_1_1 hd_h_ml302.tu2_1_2_2_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">TSRI</td><td headers="hd_h_ml302.tu2_1_2_1_1 hd_h_ml302.tu2_1_2_2_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">None</td><td headers="hd_h_ml302.tu2_1_2_1_2 hd_h_ml302.tu2_1_2_2_9 hd_h_ml302.tu2_1_2_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_2_1_2 hd_h_ml302.tu2_1_2_2_9 hd_h_ml302.tu2_1_2_3_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_2_1_2 hd_h_ml302.tu2_1_2_2_10 hd_h_ml302.tu2_1_2_3_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">25</td><td headers="hd_h_ml302.tu2_1_2_1_2 hd_h_ml302.tu2_1_2_2_10 hd_h_ml302.tu2_1_2_3_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Prepared in 75/25 DMSO/H2O</td><td headers="hd_h_ml302.tu2_1_2_1_2 hd_h_ml302.tu2_1_2_2_11 hd_h_ml302.tu2_1_2_3_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_2_1_2 hd_h_ml302.tu2_1_2_2_11 hd_h_ml302.tu2_1_2_3_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_2_1_2 hd_h_ml302.tu2_1_2_2_12 hd_h_ml302.tu2_1_2_3_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">>100</td><td headers="hd_h_ml302.tu2_1_2_1_2 hd_h_ml302.tu2_1_2_2_12 hd_h_ml302.tu2_1_2_3_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_2_1_2 hd_h_ml302.tu2_1_2_2_13 hd_h_ml302.tu2_1_2_3_9" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_2_1_2 hd_h_ml302.tu2_1_2_2_14 hd_h_ml302.tu2_1_2_3_10" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_2_1_3 hd_h_ml302.tu2_1_2_2_15 hd_h_ml302.tu2_1_2_3_11" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_2_1_3 hd_h_ml302.tu2_1_2_2_16 hd_h_ml302.tu2_1_2_3_12" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_2_1_3 hd_h_ml302.tu2_1_2_2_17 hd_h_ml302.tu2_1_2_3_13" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td></tr><tr><td headers="hd_h_ml302.tu2_1_2_1_1 hd_h_ml302.tu2_1_2_2_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Analog 7 (purchased for reference)</td><td headers="hd_h_ml302.tu2_1_2_1_1 hd_h_ml302.tu2_1_2_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-01000216818-7</td><td headers="hd_h_ml302.tu2_1_2_1_1 hd_h_ml302.tu2_1_2_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">
|
||
<div class="graphic"><img src="/books/NBK143563/bin/ml302fu9.jpg" alt="Image ml302fu9.jpg" /></div></td><td headers="hd_h_ml302.tu2_1_2_1_1 hd_h_ml302.tu2_1_2_2_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">1733268</td><td headers="hd_h_ml302.tu2_1_2_1_1 hd_h_ml302.tu2_1_2_2_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/124360376" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">124360376</a></td><td headers="hd_h_ml302.tu2_1_2_1_1 hd_h_ml302.tu2_1_2_2_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_2_1_1 hd_h_ml302.tu2_1_2_2_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ChemBridge</td><td headers="hd_h_ml302.tu2_1_2_1_1 hd_h_ml302.tu2_1_2_2_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">5680564</td><td headers="hd_h_ml302.tu2_1_2_1_2 hd_h_ml302.tu2_1_2_2_9 hd_h_ml302.tu2_1_2_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_2_1_2 hd_h_ml302.tu2_1_2_2_9 hd_h_ml302.tu2_1_2_3_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_2_1_2 hd_h_ml302.tu2_1_2_2_10 hd_h_ml302.tu2_1_2_3_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">3.125</td><td headers="hd_h_ml302.tu2_1_2_1_2 hd_h_ml302.tu2_1_2_2_10 hd_h_ml302.tu2_1_2_3_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Prepared in neat DMSO</td><td headers="hd_h_ml302.tu2_1_2_1_2 hd_h_ml302.tu2_1_2_2_11 hd_h_ml302.tu2_1_2_3_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_2_1_2 hd_h_ml302.tu2_1_2_2_11 hd_h_ml302.tu2_1_2_3_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_2_1_2 hd_h_ml302.tu2_1_2_2_12 hd_h_ml302.tu2_1_2_3_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_2_1_2 hd_h_ml302.tu2_1_2_2_12 hd_h_ml302.tu2_1_2_3_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_2_1_2 hd_h_ml302.tu2_1_2_2_13 hd_h_ml302.tu2_1_2_3_9" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_2_1_2 hd_h_ml302.tu2_1_2_2_14 hd_h_ml302.tu2_1_2_3_10" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_2_1_3 hd_h_ml302.tu2_1_2_2_15 hd_h_ml302.tu2_1_2_3_11" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_2_1_3 hd_h_ml302.tu2_1_2_2_16 hd_h_ml302.tu2_1_2_3_12" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_2_1_3 hd_h_ml302.tu2_1_2_2_17 hd_h_ml302.tu2_1_2_3_13" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td></tr><tr><td headers="hd_h_ml302.tu2_1_2_1_1 hd_h_ml302.tu2_1_2_2_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Analog 7 (resynthesized)</td><td headers="hd_h_ml302.tu2_1_2_1_1 hd_h_ml302.tu2_1_2_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-01000216818-8</td><td headers="hd_h_ml302.tu2_1_2_1_1 hd_h_ml302.tu2_1_2_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">
|
||
<div class="graphic"><img src="/books/NBK143563/bin/ml302fu9.jpg" alt="Image ml302fu9.jpg" /></div></td><td headers="hd_h_ml302.tu2_1_2_1_1 hd_h_ml302.tu2_1_2_2_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">1733268</td><td headers="hd_h_ml302.tu2_1_2_1_1 hd_h_ml302.tu2_1_2_2_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/124384965" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">124384965</a></td><td headers="hd_h_ml302.tu2_1_2_1_1 hd_h_ml302.tu2_1_2_2_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">003940498</td><td headers="hd_h_ml302.tu2_1_2_1_1 hd_h_ml302.tu2_1_2_2_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">TSRI</td><td headers="hd_h_ml302.tu2_1_2_1_1 hd_h_ml302.tu2_1_2_2_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">None</td><td headers="hd_h_ml302.tu2_1_2_1_2 hd_h_ml302.tu2_1_2_2_9 hd_h_ml302.tu2_1_2_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">6.25</td><td headers="hd_h_ml302.tu2_1_2_1_2 hd_h_ml302.tu2_1_2_2_9 hd_h_ml302.tu2_1_2_3_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">8X</td><td headers="hd_h_ml302.tu2_1_2_1_2 hd_h_ml302.tu2_1_2_2_10 hd_h_ml302.tu2_1_2_3_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">6.25</td><td headers="hd_h_ml302.tu2_1_2_1_2 hd_h_ml302.tu2_1_2_2_10 hd_h_ml302.tu2_1_2_3_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">32X</td><td headers="hd_h_ml302.tu2_1_2_1_2 hd_h_ml302.tu2_1_2_2_11 hd_h_ml302.tu2_1_2_3_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">>100</td><td headers="hd_h_ml302.tu2_1_2_1_2 hd_h_ml302.tu2_1_2_2_11 hd_h_ml302.tu2_1_2_3_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_2_1_2 hd_h_ml302.tu2_1_2_2_12 hd_h_ml302.tu2_1_2_3_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">>100</td><td headers="hd_h_ml302.tu2_1_2_1_2 hd_h_ml302.tu2_1_2_2_12 hd_h_ml302.tu2_1_2_3_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">2X</td><td headers="hd_h_ml302.tu2_1_2_1_2 hd_h_ml302.tu2_1_2_2_13 hd_h_ml302.tu2_1_2_3_9" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">>100</td><td headers="hd_h_ml302.tu2_1_2_1_2 hd_h_ml302.tu2_1_2_2_14 hd_h_ml302.tu2_1_2_3_10" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">25</td><td headers="hd_h_ml302.tu2_1_2_1_3 hd_h_ml302.tu2_1_2_2_15 hd_h_ml302.tu2_1_2_3_11" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">3.98</td><td headers="hd_h_ml302.tu2_1_2_1_3 hd_h_ml302.tu2_1_2_2_16 hd_h_ml302.tu2_1_2_3_12" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">31.9</td><td headers="hd_h_ml302.tu2_1_2_1_3 hd_h_ml302.tu2_1_2_2_17 hd_h_ml302.tu2_1_2_3_13" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td></tr><tr><td headers="hd_h_ml302.tu2_1_2_1_1 hd_h_ml302.tu2_1_2_2_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Analog 8</td><td headers="hd_h_ml302.tu2_1_2_1_1 hd_h_ml302.tu2_1_2_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-03000002375-1</td><td headers="hd_h_ml302.tu2_1_2_1_1 hd_h_ml302.tu2_1_2_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">
|
||
<div class="graphic"><img src="/books/NBK143563/bin/ml302fu10.jpg" alt="Image ml302fu10.jpg" /></div></td><td headers="hd_h_ml302.tu2_1_2_1_1 hd_h_ml302.tu2_1_2_2_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">53257035</td><td headers="hd_h_ml302.tu2_1_2_1_1 hd_h_ml302.tu2_1_2_2_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/124398381" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">124398381</a></td><td headers="hd_h_ml302.tu2_1_2_1_1 hd_h_ml302.tu2_1_2_2_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_2_1_1 hd_h_ml302.tu2_1_2_2_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">TSRI</td><td headers="hd_h_ml302.tu2_1_2_1_1 hd_h_ml302.tu2_1_2_2_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">None</td><td headers="hd_h_ml302.tu2_1_2_1_2 hd_h_ml302.tu2_1_2_2_9 hd_h_ml302.tu2_1_2_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">>100</td><td headers="hd_h_ml302.tu2_1_2_1_2 hd_h_ml302.tu2_1_2_2_9 hd_h_ml302.tu2_1_2_3_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_2_1_2 hd_h_ml302.tu2_1_2_2_10 hd_h_ml302.tu2_1_2_3_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_2_1_2 hd_h_ml302.tu2_1_2_2_10 hd_h_ml302.tu2_1_2_3_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_2_1_2 hd_h_ml302.tu2_1_2_2_11 hd_h_ml302.tu2_1_2_3_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_2_1_2 hd_h_ml302.tu2_1_2_2_11 hd_h_ml302.tu2_1_2_3_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_2_1_2 hd_h_ml302.tu2_1_2_2_12 hd_h_ml302.tu2_1_2_3_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_2_1_2 hd_h_ml302.tu2_1_2_2_12 hd_h_ml302.tu2_1_2_3_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_2_1_2 hd_h_ml302.tu2_1_2_2_13 hd_h_ml302.tu2_1_2_3_9" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_2_1_2 hd_h_ml302.tu2_1_2_2_14 hd_h_ml302.tu2_1_2_3_10" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_2_1_3 hd_h_ml302.tu2_1_2_2_15 hd_h_ml302.tu2_1_2_3_11" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_2_1_3 hd_h_ml302.tu2_1_2_2_16 hd_h_ml302.tu2_1_2_3_12" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_2_1_3 hd_h_ml302.tu2_1_2_2_17 hd_h_ml302.tu2_1_2_3_13" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td></tr><tr><td headers="hd_h_ml302.tu2_1_2_1_1 hd_h_ml302.tu2_1_2_2_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Analog 9</td><td headers="hd_h_ml302.tu2_1_2_1_1 hd_h_ml302.tu2_1_2_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-03000002376-1</td><td headers="hd_h_ml302.tu2_1_2_1_1 hd_h_ml302.tu2_1_2_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">
|
||
<div class="graphic"><img src="/books/NBK143563/bin/ml302fu11.jpg" alt="Image ml302fu11.jpg" /></div></td><td headers="hd_h_ml302.tu2_1_2_1_1 hd_h_ml302.tu2_1_2_2_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">53257030</td><td headers="hd_h_ml302.tu2_1_2_1_1 hd_h_ml302.tu2_1_2_2_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/124398382" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">124398382</a></td><td headers="hd_h_ml302.tu2_1_2_1_1 hd_h_ml302.tu2_1_2_2_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_2_1_1 hd_h_ml302.tu2_1_2_2_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">TSRI</td><td headers="hd_h_ml302.tu2_1_2_1_1 hd_h_ml302.tu2_1_2_2_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">None</td><td headers="hd_h_ml302.tu2_1_2_1_2 hd_h_ml302.tu2_1_2_2_9 hd_h_ml302.tu2_1_2_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">>100</td><td headers="hd_h_ml302.tu2_1_2_1_2 hd_h_ml302.tu2_1_2_2_9 hd_h_ml302.tu2_1_2_3_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_2_1_2 hd_h_ml302.tu2_1_2_2_10 hd_h_ml302.tu2_1_2_3_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_2_1_2 hd_h_ml302.tu2_1_2_2_10 hd_h_ml302.tu2_1_2_3_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_2_1_2 hd_h_ml302.tu2_1_2_2_11 hd_h_ml302.tu2_1_2_3_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_2_1_2 hd_h_ml302.tu2_1_2_2_11 hd_h_ml302.tu2_1_2_3_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_2_1_2 hd_h_ml302.tu2_1_2_2_12 hd_h_ml302.tu2_1_2_3_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_2_1_2 hd_h_ml302.tu2_1_2_2_12 hd_h_ml302.tu2_1_2_3_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_2_1_2 hd_h_ml302.tu2_1_2_2_13 hd_h_ml302.tu2_1_2_3_9" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_2_1_2 hd_h_ml302.tu2_1_2_2_14 hd_h_ml302.tu2_1_2_3_10" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_2_1_3 hd_h_ml302.tu2_1_2_2_15 hd_h_ml302.tu2_1_2_3_11" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_2_1_3 hd_h_ml302.tu2_1_2_2_16 hd_h_ml302.tu2_1_2_3_12" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_2_1_3 hd_h_ml302.tu2_1_2_2_17 hd_h_ml302.tu2_1_2_3_13" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td></tr><tr><td headers="hd_h_ml302.tu2_1_2_1_1 hd_h_ml302.tu2_1_2_2_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Analog 10</td><td headers="hd_h_ml302.tu2_1_2_1_1 hd_h_ml302.tu2_1_2_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-03000002377-1</td><td headers="hd_h_ml302.tu2_1_2_1_1 hd_h_ml302.tu2_1_2_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">
|
||
<div class="graphic"><img src="/books/NBK143563/bin/ml302fu12.jpg" alt="Image ml302fu12.jpg" /></div></td><td headers="hd_h_ml302.tu2_1_2_1_1 hd_h_ml302.tu2_1_2_2_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">53257026</td><td headers="hd_h_ml302.tu2_1_2_1_1 hd_h_ml302.tu2_1_2_2_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/124398383" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">124398383</a></td><td headers="hd_h_ml302.tu2_1_2_1_1 hd_h_ml302.tu2_1_2_2_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_2_1_1 hd_h_ml302.tu2_1_2_2_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">TSRI</td><td headers="hd_h_ml302.tu2_1_2_1_1 hd_h_ml302.tu2_1_2_2_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">None</td><td headers="hd_h_ml302.tu2_1_2_1_2 hd_h_ml302.tu2_1_2_2_9 hd_h_ml302.tu2_1_2_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">>100</td><td headers="hd_h_ml302.tu2_1_2_1_2 hd_h_ml302.tu2_1_2_2_9 hd_h_ml302.tu2_1_2_3_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_2_1_2 hd_h_ml302.tu2_1_2_2_10 hd_h_ml302.tu2_1_2_3_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_2_1_2 hd_h_ml302.tu2_1_2_2_10 hd_h_ml302.tu2_1_2_3_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_2_1_2 hd_h_ml302.tu2_1_2_2_11 hd_h_ml302.tu2_1_2_3_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_2_1_2 hd_h_ml302.tu2_1_2_2_11 hd_h_ml302.tu2_1_2_3_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_2_1_2 hd_h_ml302.tu2_1_2_2_12 hd_h_ml302.tu2_1_2_3_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_2_1_2 hd_h_ml302.tu2_1_2_2_12 hd_h_ml302.tu2_1_2_3_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_2_1_2 hd_h_ml302.tu2_1_2_2_13 hd_h_ml302.tu2_1_2_3_9" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_2_1_2 hd_h_ml302.tu2_1_2_2_14 hd_h_ml302.tu2_1_2_3_10" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_2_1_3 hd_h_ml302.tu2_1_2_2_15 hd_h_ml302.tu2_1_2_3_11" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_2_1_3 hd_h_ml302.tu2_1_2_2_16 hd_h_ml302.tu2_1_2_3_12" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_2_1_3 hd_h_ml302.tu2_1_2_2_17 hd_h_ml302.tu2_1_2_3_13" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td></tr></tbody></table><table><thead><tr><th id="hd_h_ml302.tu2_1_3_1_1" colspan="8" rowspan="1" style="text-align:center;vertical-align:middle;">Compound Information</th><th id="hd_h_ml302.tu2_1_3_1_2" colspan="10" rowspan="1" style="text-align:center;vertical-align:middle;">Bioassays</th></tr><tr><th headers="hd_h_ml302.tu2_1_3_1_1 hd_h_ml302.tu2_1_3_2_1" id="hd_h_ml302.tu2_1_3_2_1" rowspan="2" colspan="1" style="text-align:center;vertical-align:middle;">Compound</th><th headers="hd_h_ml302.tu2_1_3_1_1 hd_h_ml302.tu2_1_3_2_2" id="hd_h_ml302.tu2_1_3_2_2" rowspan="2" colspan="1" style="text-align:center;vertical-align:middle;">SR-Number</th><th headers="hd_h_ml302.tu2_1_3_1_1 hd_h_ml302.tu2_1_3_2_3" id="hd_h_ml302.tu2_1_3_2_3" rowspan="2" colspan="1" style="text-align:center;vertical-align:middle;">Structure</th><th headers="hd_h_ml302.tu2_1_3_1_1 hd_h_ml302.tu2_1_3_2_4" id="hd_h_ml302.tu2_1_3_2_4" rowspan="2" colspan="1" style="text-align:center;vertical-align:middle;">CID</th><th headers="hd_h_ml302.tu2_1_3_1_1 hd_h_ml302.tu2_1_3_2_5" id="hd_h_ml302.tu2_1_3_2_5" rowspan="2" colspan="1" style="text-align:center;vertical-align:middle;">SID</th><th headers="hd_h_ml302.tu2_1_3_1_1 hd_h_ml302.tu2_1_3_2_6" id="hd_h_ml302.tu2_1_3_2_6" rowspan="2" colspan="1" style="text-align:center;vertical-align:middle;">MLS</th><th headers="hd_h_ml302.tu2_1_3_1_1 hd_h_ml302.tu2_1_3_2_7" id="hd_h_ml302.tu2_1_3_2_7" rowspan="2" colspan="1" style="text-align:center;vertical-align:middle;">Vendor</th><th headers="hd_h_ml302.tu2_1_3_1_1 hd_h_ml302.tu2_1_3_2_8" id="hd_h_ml302.tu2_1_3_2_8" rowspan="2" colspan="1" style="text-align:center;vertical-align:middle;">Vendor Catalog ID</th><th headers="hd_h_ml302.tu2_1_3_1_2" id="hd_h_ml302.tu2_1_3_2_9" colspan="2" rowspan="1" style="text-align:center;vertical-align:middle;">BL21 (VIM-2)</th><th headers="hd_h_ml302.tu2_1_3_1_2" id="hd_h_ml302.tu2_1_3_2_10" colspan="2" rowspan="1" style="text-align:center;vertical-align:middle;">YMC07/B3323 (VIM-2)</th><th headers="hd_h_ml302.tu2_1_3_1_2" id="hd_h_ml302.tu2_1_3_2_11" colspan="2" rowspan="1" style="text-align:center;vertical-align:top;">BAA-2146 (NDM-1)</th><th headers="hd_h_ml302.tu2_1_3_1_2" id="hd_h_ml302.tu2_1_3_2_12" colspan="2" rowspan="1" style="text-align:center;vertical-align:middle;">PA641 (VIM-2)</th><th headers="hd_h_ml302.tu2_1_3_1_2" id="hd_h_ml302.tu2_1_3_2_13" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">KN20</th><th headers="hd_h_ml302.tu2_1_3_1_2" id="hd_h_ml302.tu2_1_3_2_14" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">BL21</th></tr><tr><th headers="hd_h_ml302.tu2_1_3_1_2 hd_h_ml302.tu2_1_3_2_9" id="hd_h_ml302.tu2_1_3_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">MIC 4× (μM)</th><th headers="hd_h_ml302.tu2_1_3_1_2 hd_h_ml302.tu2_1_3_2_9" id="hd_h_ml302.tu2_1_3_3_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Imipenem Potentiation</th><th headers="hd_h_ml302.tu2_1_3_1_2 hd_h_ml302.tu2_1_3_2_10" id="hd_h_ml302.tu2_1_3_3_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">MIC 4× (μM)</th><th headers="hd_h_ml302.tu2_1_3_1_2 hd_h_ml302.tu2_1_3_2_10" id="hd_h_ml302.tu2_1_3_3_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Imipenem Potentiation</th><th headers="hd_h_ml302.tu2_1_3_1_2 hd_h_ml302.tu2_1_3_2_11" id="hd_h_ml302.tu2_1_3_3_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MIC 4× (μM)</th><th headers="hd_h_ml302.tu2_1_3_1_2 hd_h_ml302.tu2_1_3_2_11" id="hd_h_ml302.tu2_1_3_3_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Imipenem Potentiation</th><th headers="hd_h_ml302.tu2_1_3_1_2 hd_h_ml302.tu2_1_3_2_12" id="hd_h_ml302.tu2_1_3_3_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">MIC 4× (μM)</th><th headers="hd_h_ml302.tu2_1_3_1_2 hd_h_ml302.tu2_1_3_2_12" id="hd_h_ml302.tu2_1_3_3_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Imipenem Potentiation</th><th headers="hd_h_ml302.tu2_1_3_1_2 hd_h_ml302.tu2_1_3_2_13" id="hd_h_ml302.tu2_1_3_3_9" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">MIC 4× (μM)</th><th headers="hd_h_ml302.tu2_1_3_1_2 hd_h_ml302.tu2_1_3_2_14" id="hd_h_ml302.tu2_1_3_3_10" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">MIC 4× (μM)</th></tr></thead><tbody><tr><td headers="hd_h_ml302.tu2_1_3_1_1 hd_h_ml302.tu2_1_3_2_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Analog 11</td><td headers="hd_h_ml302.tu2_1_3_1_1 hd_h_ml302.tu2_1_3_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-03000002380-1</td><td headers="hd_h_ml302.tu2_1_3_1_1 hd_h_ml302.tu2_1_3_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">
|
||
<div class="graphic"><img src="/books/NBK143563/bin/ml302fu13.jpg" alt="Image ml302fu13.jpg" /></div></td><td headers="hd_h_ml302.tu2_1_3_1_1 hd_h_ml302.tu2_1_3_2_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">53257031</td><td headers="hd_h_ml302.tu2_1_3_1_1 hd_h_ml302.tu2_1_3_2_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/124398386" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">124398386</a></td><td headers="hd_h_ml302.tu2_1_3_1_1 hd_h_ml302.tu2_1_3_2_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_3_1_1 hd_h_ml302.tu2_1_3_2_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">TSRI</td><td headers="hd_h_ml302.tu2_1_3_1_1 hd_h_ml302.tu2_1_3_2_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">None</td><td headers="hd_h_ml302.tu2_1_3_1_2 hd_h_ml302.tu2_1_3_2_9 hd_h_ml302.tu2_1_3_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">>100</td><td headers="hd_h_ml302.tu2_1_3_1_2 hd_h_ml302.tu2_1_3_2_9 hd_h_ml302.tu2_1_3_3_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_3_1_2 hd_h_ml302.tu2_1_3_2_10 hd_h_ml302.tu2_1_3_3_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_3_1_2 hd_h_ml302.tu2_1_3_2_10 hd_h_ml302.tu2_1_3_3_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_3_1_2 hd_h_ml302.tu2_1_3_2_11 hd_h_ml302.tu2_1_3_3_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_3_1_2 hd_h_ml302.tu2_1_3_2_11 hd_h_ml302.tu2_1_3_3_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_3_1_2 hd_h_ml302.tu2_1_3_2_12 hd_h_ml302.tu2_1_3_3_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_3_1_2 hd_h_ml302.tu2_1_3_2_12 hd_h_ml302.tu2_1_3_3_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_3_1_2 hd_h_ml302.tu2_1_3_2_13 hd_h_ml302.tu2_1_3_3_9" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_3_1_2 hd_h_ml302.tu2_1_3_2_14 hd_h_ml302.tu2_1_3_3_10" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td></tr><tr><td headers="hd_h_ml302.tu2_1_3_1_1 hd_h_ml302.tu2_1_3_2_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Analog 12</td><td headers="hd_h_ml302.tu2_1_3_1_1 hd_h_ml302.tu2_1_3_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-03000002381-1</td><td headers="hd_h_ml302.tu2_1_3_1_1 hd_h_ml302.tu2_1_3_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">
|
||
<div class="graphic"><img src="/books/NBK143563/bin/ml302fu14.jpg" alt="Image ml302fu14.jpg" /></div></td><td headers="hd_h_ml302.tu2_1_3_1_1 hd_h_ml302.tu2_1_3_2_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">53257037</td><td headers="hd_h_ml302.tu2_1_3_1_1 hd_h_ml302.tu2_1_3_2_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/124398404" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">124398404</a></td><td headers="hd_h_ml302.tu2_1_3_1_1 hd_h_ml302.tu2_1_3_2_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_3_1_1 hd_h_ml302.tu2_1_3_2_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">TSRI</td><td headers="hd_h_ml302.tu2_1_3_1_1 hd_h_ml302.tu2_1_3_2_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">None</td><td headers="hd_h_ml302.tu2_1_3_1_2 hd_h_ml302.tu2_1_3_2_9 hd_h_ml302.tu2_1_3_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">12.5</td><td headers="hd_h_ml302.tu2_1_3_1_2 hd_h_ml302.tu2_1_3_2_9 hd_h_ml302.tu2_1_3_3_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">8X</td><td headers="hd_h_ml302.tu2_1_3_1_2 hd_h_ml302.tu2_1_3_2_10 hd_h_ml302.tu2_1_3_3_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_3_1_2 hd_h_ml302.tu2_1_3_2_10 hd_h_ml302.tu2_1_3_3_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_3_1_2 hd_h_ml302.tu2_1_3_2_11 hd_h_ml302.tu2_1_3_3_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_3_1_2 hd_h_ml302.tu2_1_3_2_11 hd_h_ml302.tu2_1_3_3_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_3_1_2 hd_h_ml302.tu2_1_3_2_12 hd_h_ml302.tu2_1_3_3_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_3_1_2 hd_h_ml302.tu2_1_3_2_12 hd_h_ml302.tu2_1_3_3_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_3_1_2 hd_h_ml302.tu2_1_3_2_13 hd_h_ml302.tu2_1_3_3_9" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_3_1_2 hd_h_ml302.tu2_1_3_2_14 hd_h_ml302.tu2_1_3_3_10" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td></tr><tr><td headers="hd_h_ml302.tu2_1_3_1_1 hd_h_ml302.tu2_1_3_2_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Analog 13</td><td headers="hd_h_ml302.tu2_1_3_1_1 hd_h_ml302.tu2_1_3_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-03000002461-1</td><td headers="hd_h_ml302.tu2_1_3_1_1 hd_h_ml302.tu2_1_3_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">
|
||
<div class="graphic"><img src="/books/NBK143563/bin/ml302fu15.jpg" alt="Image ml302fu15.jpg" /></div></td><td headers="hd_h_ml302.tu2_1_3_1_1 hd_h_ml302.tu2_1_3_2_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">1382782</td><td headers="hd_h_ml302.tu2_1_3_1_1 hd_h_ml302.tu2_1_3_2_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/125001880" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">125001880</a></td><td headers="hd_h_ml302.tu2_1_3_1_1 hd_h_ml302.tu2_1_3_2_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_3_1_1 hd_h_ml302.tu2_1_3_2_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Vitas-M Lab</td><td headers="hd_h_ml302.tu2_1_3_1_1 hd_h_ml302.tu2_1_3_2_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">STL035211</td><td headers="hd_h_ml302.tu2_1_3_1_2 hd_h_ml302.tu2_1_3_2_9 hd_h_ml302.tu2_1_3_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_3_1_2 hd_h_ml302.tu2_1_3_2_9 hd_h_ml302.tu2_1_3_3_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_3_1_2 hd_h_ml302.tu2_1_3_2_10 hd_h_ml302.tu2_1_3_3_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">6.25</td><td headers="hd_h_ml302.tu2_1_3_1_2 hd_h_ml302.tu2_1_3_2_10 hd_h_ml302.tu2_1_3_3_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">16X</td><td headers="hd_h_ml302.tu2_1_3_1_2 hd_h_ml302.tu2_1_3_2_11 hd_h_ml302.tu2_1_3_3_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_3_1_2 hd_h_ml302.tu2_1_3_2_11 hd_h_ml302.tu2_1_3_3_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_3_1_2 hd_h_ml302.tu2_1_3_2_12 hd_h_ml302.tu2_1_3_3_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_3_1_2 hd_h_ml302.tu2_1_3_2_12 hd_h_ml302.tu2_1_3_3_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_3_1_2 hd_h_ml302.tu2_1_3_2_13 hd_h_ml302.tu2_1_3_3_9" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_3_1_2 hd_h_ml302.tu2_1_3_2_14 hd_h_ml302.tu2_1_3_3_10" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td></tr><tr><td headers="hd_h_ml302.tu2_1_3_1_1 hd_h_ml302.tu2_1_3_2_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Analog 14</td><td headers="hd_h_ml302.tu2_1_3_1_1 hd_h_ml302.tu2_1_3_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-03000002378-1</td><td headers="hd_h_ml302.tu2_1_3_1_1 hd_h_ml302.tu2_1_3_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">
|
||
<div class="graphic"><img src="/books/NBK143563/bin/ml302fu16.jpg" alt="Image ml302fu16.jpg" /></div></td><td headers="hd_h_ml302.tu2_1_3_1_1 hd_h_ml302.tu2_1_3_2_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">53257011</td><td headers="hd_h_ml302.tu2_1_3_1_1 hd_h_ml302.tu2_1_3_2_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/124398384" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">124398384</a></td><td headers="hd_h_ml302.tu2_1_3_1_1 hd_h_ml302.tu2_1_3_2_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_3_1_1 hd_h_ml302.tu2_1_3_2_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">TSRI</td><td headers="hd_h_ml302.tu2_1_3_1_1 hd_h_ml302.tu2_1_3_2_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">None</td><td headers="hd_h_ml302.tu2_1_3_1_2 hd_h_ml302.tu2_1_3_2_9 hd_h_ml302.tu2_1_3_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">6.2</td><td headers="hd_h_ml302.tu2_1_3_1_2 hd_h_ml302.tu2_1_3_2_9 hd_h_ml302.tu2_1_3_3_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">8X</td><td headers="hd_h_ml302.tu2_1_3_1_2 hd_h_ml302.tu2_1_3_2_10 hd_h_ml302.tu2_1_3_3_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">6.25</td><td headers="hd_h_ml302.tu2_1_3_1_2 hd_h_ml302.tu2_1_3_2_10 hd_h_ml302.tu2_1_3_3_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">16X</td><td headers="hd_h_ml302.tu2_1_3_1_2 hd_h_ml302.tu2_1_3_2_11 hd_h_ml302.tu2_1_3_3_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">>100</td><td headers="hd_h_ml302.tu2_1_3_1_2 hd_h_ml302.tu2_1_3_2_11 hd_h_ml302.tu2_1_3_3_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_3_1_2 hd_h_ml302.tu2_1_3_2_12 hd_h_ml302.tu2_1_3_3_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">>100</td><td headers="hd_h_ml302.tu2_1_3_1_2 hd_h_ml302.tu2_1_3_2_12 hd_h_ml302.tu2_1_3_3_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">2X</td><td headers="hd_h_ml302.tu2_1_3_1_2 hd_h_ml302.tu2_1_3_2_13 hd_h_ml302.tu2_1_3_3_9" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">>100</td><td headers="hd_h_ml302.tu2_1_3_1_2 hd_h_ml302.tu2_1_3_2_14 hd_h_ml302.tu2_1_3_3_10" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td></tr><tr><td headers="hd_h_ml302.tu2_1_3_1_1 hd_h_ml302.tu2_1_3_2_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Analog 15</td><td headers="hd_h_ml302.tu2_1_3_1_1 hd_h_ml302.tu2_1_3_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-03000002379-1</td><td headers="hd_h_ml302.tu2_1_3_1_1 hd_h_ml302.tu2_1_3_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">
|
||
<div class="graphic"><img src="/books/NBK143563/bin/ml302fu17.jpg" alt="Image ml302fu17.jpg" /></div></td><td headers="hd_h_ml302.tu2_1_3_1_1 hd_h_ml302.tu2_1_3_2_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">53257036</td><td headers="hd_h_ml302.tu2_1_3_1_1 hd_h_ml302.tu2_1_3_2_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/124398385" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">124398385</a></td><td headers="hd_h_ml302.tu2_1_3_1_1 hd_h_ml302.tu2_1_3_2_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_3_1_1 hd_h_ml302.tu2_1_3_2_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">TSRI</td><td headers="hd_h_ml302.tu2_1_3_1_1 hd_h_ml302.tu2_1_3_2_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">None</td><td headers="hd_h_ml302.tu2_1_3_1_2 hd_h_ml302.tu2_1_3_2_9 hd_h_ml302.tu2_1_3_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">12.5</td><td headers="hd_h_ml302.tu2_1_3_1_2 hd_h_ml302.tu2_1_3_2_9 hd_h_ml302.tu2_1_3_3_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_3_1_2 hd_h_ml302.tu2_1_3_2_10 hd_h_ml302.tu2_1_3_3_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">6.25</td><td headers="hd_h_ml302.tu2_1_3_1_2 hd_h_ml302.tu2_1_3_2_10 hd_h_ml302.tu2_1_3_3_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">16X</td><td headers="hd_h_ml302.tu2_1_3_1_2 hd_h_ml302.tu2_1_3_2_11 hd_h_ml302.tu2_1_3_3_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_3_1_2 hd_h_ml302.tu2_1_3_2_11 hd_h_ml302.tu2_1_3_3_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_3_1_2 hd_h_ml302.tu2_1_3_2_12 hd_h_ml302.tu2_1_3_3_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_3_1_2 hd_h_ml302.tu2_1_3_2_12 hd_h_ml302.tu2_1_3_3_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_3_1_2 hd_h_ml302.tu2_1_3_2_13 hd_h_ml302.tu2_1_3_3_9" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_3_1_2 hd_h_ml302.tu2_1_3_2_14 hd_h_ml302.tu2_1_3_3_10" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td></tr><tr><td headers="hd_h_ml302.tu2_1_3_1_1 hd_h_ml302.tu2_1_3_2_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Analog 16</td><td headers="hd_h_ml302.tu2_1_3_1_1 hd_h_ml302.tu2_1_3_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-03000002395-1</td><td headers="hd_h_ml302.tu2_1_3_1_1 hd_h_ml302.tu2_1_3_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">
|
||
<div class="graphic"><img src="/books/NBK143563/bin/ml302fu18.jpg" alt="Image ml302fu18.jpg" /></div></td><td headers="hd_h_ml302.tu2_1_3_1_1 hd_h_ml302.tu2_1_3_2_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">53301882</td><td headers="hd_h_ml302.tu2_1_3_1_1 hd_h_ml302.tu2_1_3_2_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/124756530" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">124756530</a></td><td headers="hd_h_ml302.tu2_1_3_1_1 hd_h_ml302.tu2_1_3_2_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_3_1_1 hd_h_ml302.tu2_1_3_2_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">TSRI</td><td headers="hd_h_ml302.tu2_1_3_1_1 hd_h_ml302.tu2_1_3_2_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">None</td><td headers="hd_h_ml302.tu2_1_3_1_2 hd_h_ml302.tu2_1_3_2_9 hd_h_ml302.tu2_1_3_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">>100</td><td headers="hd_h_ml302.tu2_1_3_1_2 hd_h_ml302.tu2_1_3_2_9 hd_h_ml302.tu2_1_3_3_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_3_1_2 hd_h_ml302.tu2_1_3_2_10 hd_h_ml302.tu2_1_3_3_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_3_1_2 hd_h_ml302.tu2_1_3_2_10 hd_h_ml302.tu2_1_3_3_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_3_1_2 hd_h_ml302.tu2_1_3_2_11 hd_h_ml302.tu2_1_3_3_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_3_1_2 hd_h_ml302.tu2_1_3_2_11 hd_h_ml302.tu2_1_3_3_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_3_1_2 hd_h_ml302.tu2_1_3_2_12 hd_h_ml302.tu2_1_3_3_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_3_1_2 hd_h_ml302.tu2_1_3_2_12 hd_h_ml302.tu2_1_3_3_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_3_1_2 hd_h_ml302.tu2_1_3_2_13 hd_h_ml302.tu2_1_3_3_9" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_3_1_2 hd_h_ml302.tu2_1_3_2_14 hd_h_ml302.tu2_1_3_3_10" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td></tr><tr><td headers="hd_h_ml302.tu2_1_3_1_1 hd_h_ml302.tu2_1_3_2_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Analog 17</td><td headers="hd_h_ml302.tu2_1_3_1_1 hd_h_ml302.tu2_1_3_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-03000002396-1</td><td headers="hd_h_ml302.tu2_1_3_1_1 hd_h_ml302.tu2_1_3_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">
|
||
<div class="graphic"><img src="/books/NBK143563/bin/ml302fu19.jpg" alt="Image ml302fu19.jpg" /></div></td><td headers="hd_h_ml302.tu2_1_3_1_1 hd_h_ml302.tu2_1_3_2_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">53301881</td><td headers="hd_h_ml302.tu2_1_3_1_1 hd_h_ml302.tu2_1_3_2_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/124756531" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">124756531</a></td><td headers="hd_h_ml302.tu2_1_3_1_1 hd_h_ml302.tu2_1_3_2_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_3_1_1 hd_h_ml302.tu2_1_3_2_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">TSRI</td><td headers="hd_h_ml302.tu2_1_3_1_1 hd_h_ml302.tu2_1_3_2_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">None</td><td headers="hd_h_ml302.tu2_1_3_1_2 hd_h_ml302.tu2_1_3_2_9 hd_h_ml302.tu2_1_3_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">>100</td><td headers="hd_h_ml302.tu2_1_3_1_2 hd_h_ml302.tu2_1_3_2_9 hd_h_ml302.tu2_1_3_3_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_3_1_2 hd_h_ml302.tu2_1_3_2_10 hd_h_ml302.tu2_1_3_3_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_3_1_2 hd_h_ml302.tu2_1_3_2_10 hd_h_ml302.tu2_1_3_3_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_3_1_2 hd_h_ml302.tu2_1_3_2_11 hd_h_ml302.tu2_1_3_3_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_3_1_2 hd_h_ml302.tu2_1_3_2_11 hd_h_ml302.tu2_1_3_3_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_3_1_2 hd_h_ml302.tu2_1_3_2_12 hd_h_ml302.tu2_1_3_3_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_3_1_2 hd_h_ml302.tu2_1_3_2_12 hd_h_ml302.tu2_1_3_3_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_3_1_2 hd_h_ml302.tu2_1_3_2_13 hd_h_ml302.tu2_1_3_3_9" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_3_1_2 hd_h_ml302.tu2_1_3_2_14 hd_h_ml302.tu2_1_3_3_10" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td></tr><tr><td headers="hd_h_ml302.tu2_1_3_1_1 hd_h_ml302.tu2_1_3_2_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Analog 18</td><td headers="hd_h_ml302.tu2_1_3_1_1 hd_h_ml302.tu2_1_3_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-03000002433-1</td><td headers="hd_h_ml302.tu2_1_3_1_1 hd_h_ml302.tu2_1_3_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">
|
||
<div class="graphic"><img src="/books/NBK143563/bin/ml302fu20.jpg" alt="Image ml302fu20.jpg" /></div></td><td headers="hd_h_ml302.tu2_1_3_1_1 hd_h_ml302.tu2_1_3_2_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">53308614</td><td headers="hd_h_ml302.tu2_1_3_1_1 hd_h_ml302.tu2_1_3_2_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/124767337" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">124767337</a></td><td headers="hd_h_ml302.tu2_1_3_1_1 hd_h_ml302.tu2_1_3_2_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_3_1_1 hd_h_ml302.tu2_1_3_2_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">TSRI</td><td headers="hd_h_ml302.tu2_1_3_1_1 hd_h_ml302.tu2_1_3_2_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">None</td><td headers="hd_h_ml302.tu2_1_3_1_2 hd_h_ml302.tu2_1_3_2_9 hd_h_ml302.tu2_1_3_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">>100</td><td headers="hd_h_ml302.tu2_1_3_1_2 hd_h_ml302.tu2_1_3_2_9 hd_h_ml302.tu2_1_3_3_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_3_1_2 hd_h_ml302.tu2_1_3_2_10 hd_h_ml302.tu2_1_3_3_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_3_1_2 hd_h_ml302.tu2_1_3_2_10 hd_h_ml302.tu2_1_3_3_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_3_1_2 hd_h_ml302.tu2_1_3_2_11 hd_h_ml302.tu2_1_3_3_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_3_1_2 hd_h_ml302.tu2_1_3_2_11 hd_h_ml302.tu2_1_3_3_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_3_1_2 hd_h_ml302.tu2_1_3_2_12 hd_h_ml302.tu2_1_3_3_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_3_1_2 hd_h_ml302.tu2_1_3_2_12 hd_h_ml302.tu2_1_3_3_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_3_1_2 hd_h_ml302.tu2_1_3_2_13 hd_h_ml302.tu2_1_3_3_9" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_3_1_2 hd_h_ml302.tu2_1_3_2_14 hd_h_ml302.tu2_1_3_3_10" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td></tr><tr><td headers="hd_h_ml302.tu2_1_3_1_1 hd_h_ml302.tu2_1_3_2_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Analog 19</td><td headers="hd_h_ml302.tu2_1_3_1_1 hd_h_ml302.tu2_1_3_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-03000002434-1</td><td headers="hd_h_ml302.tu2_1_3_1_1 hd_h_ml302.tu2_1_3_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">
|
||
<div class="graphic"><img src="/books/NBK143563/bin/ml302fu21.jpg" alt="Image ml302fu21.jpg" /></div></td><td headers="hd_h_ml302.tu2_1_3_1_1 hd_h_ml302.tu2_1_3_2_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">53308615</td><td headers="hd_h_ml302.tu2_1_3_1_1 hd_h_ml302.tu2_1_3_2_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/124767338" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">124767338</a></td><td headers="hd_h_ml302.tu2_1_3_1_1 hd_h_ml302.tu2_1_3_2_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_3_1_1 hd_h_ml302.tu2_1_3_2_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">TSRI</td><td headers="hd_h_ml302.tu2_1_3_1_1 hd_h_ml302.tu2_1_3_2_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">None</td><td headers="hd_h_ml302.tu2_1_3_1_2 hd_h_ml302.tu2_1_3_2_9 hd_h_ml302.tu2_1_3_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">>100</td><td headers="hd_h_ml302.tu2_1_3_1_2 hd_h_ml302.tu2_1_3_2_9 hd_h_ml302.tu2_1_3_3_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_3_1_2 hd_h_ml302.tu2_1_3_2_10 hd_h_ml302.tu2_1_3_3_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_3_1_2 hd_h_ml302.tu2_1_3_2_10 hd_h_ml302.tu2_1_3_3_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_3_1_2 hd_h_ml302.tu2_1_3_2_11 hd_h_ml302.tu2_1_3_3_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_3_1_2 hd_h_ml302.tu2_1_3_2_11 hd_h_ml302.tu2_1_3_3_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_3_1_2 hd_h_ml302.tu2_1_3_2_12 hd_h_ml302.tu2_1_3_3_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_3_1_2 hd_h_ml302.tu2_1_3_2_12 hd_h_ml302.tu2_1_3_3_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_3_1_2 hd_h_ml302.tu2_1_3_2_13 hd_h_ml302.tu2_1_3_3_9" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_3_1_2 hd_h_ml302.tu2_1_3_2_14 hd_h_ml302.tu2_1_3_3_10" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td></tr></tbody></table><table><thead><tr><th id="hd_h_ml302.tu2_1_4_1_1" colspan="8" rowspan="1" style="text-align:center;vertical-align:middle;">Compound Information</th><th id="hd_h_ml302.tu2_1_4_1_2" colspan="10" rowspan="1" style="text-align:center;vertical-align:middle;">Bacterial Assays (Strain and MBL)</th><th id="hd_h_ml302.tu2_1_4_1_3" colspan="3" rowspan="1" style="text-align:center;vertical-align:middle;">Biochemical Assays</th></tr><tr><th headers="hd_h_ml302.tu2_1_4_1_1 hd_h_ml302.tu2_1_4_2_1" id="hd_h_ml302.tu2_1_4_2_1" rowspan="2" colspan="1" style="text-align:center;vertical-align:middle;">Compound</th><th headers="hd_h_ml302.tu2_1_4_1_1 hd_h_ml302.tu2_1_4_2_2" id="hd_h_ml302.tu2_1_4_2_2" rowspan="2" colspan="1" style="text-align:center;vertical-align:middle;">SR-Number</th><th headers="hd_h_ml302.tu2_1_4_1_1 hd_h_ml302.tu2_1_4_2_3" id="hd_h_ml302.tu2_1_4_2_3" rowspan="2" colspan="1" style="text-align:center;vertical-align:middle;">Structure</th><th headers="hd_h_ml302.tu2_1_4_1_1 hd_h_ml302.tu2_1_4_2_4" id="hd_h_ml302.tu2_1_4_2_4" rowspan="2" colspan="1" style="text-align:center;vertical-align:middle;">CID</th><th headers="hd_h_ml302.tu2_1_4_1_1 hd_h_ml302.tu2_1_4_2_5" id="hd_h_ml302.tu2_1_4_2_5" rowspan="2" colspan="1" style="text-align:center;vertical-align:middle;">SID</th><th headers="hd_h_ml302.tu2_1_4_1_1 hd_h_ml302.tu2_1_4_2_6" id="hd_h_ml302.tu2_1_4_2_6" rowspan="2" colspan="1" style="text-align:center;vertical-align:middle;">MLS</th><th headers="hd_h_ml302.tu2_1_4_1_1 hd_h_ml302.tu2_1_4_2_7" id="hd_h_ml302.tu2_1_4_2_7" rowspan="2" colspan="1" style="text-align:center;vertical-align:middle;">Vendor</th><th headers="hd_h_ml302.tu2_1_4_1_1 hd_h_ml302.tu2_1_4_2_8" id="hd_h_ml302.tu2_1_4_2_8" rowspan="2" colspan="1" style="text-align:center;vertical-align:middle;">Vendor Catalog ID</th><th headers="hd_h_ml302.tu2_1_4_1_2" id="hd_h_ml302.tu2_1_4_2_9" colspan="2" rowspan="1" style="text-align:center;vertical-align:middle;">BL21 (VIM-2)</th><th headers="hd_h_ml302.tu2_1_4_1_2" id="hd_h_ml302.tu2_1_4_2_10" colspan="2" rowspan="1" style="text-align:center;vertical-align:middle;">YMC07/B3323 (VIM-2)</th><th headers="hd_h_ml302.tu2_1_4_1_2" id="hd_h_ml302.tu2_1_4_2_11" colspan="2" rowspan="1" style="text-align:center;vertical-align:middle;">BAA-2146 (NDM-1)</th><th headers="hd_h_ml302.tu2_1_4_1_2" id="hd_h_ml302.tu2_1_4_2_12" colspan="2" rowspan="1" style="text-align:center;vertical-align:middle;">PA641 (VIM-2)</th><th headers="hd_h_ml302.tu2_1_4_1_2" id="hd_h_ml302.tu2_1_4_2_13" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">KN20</th><th headers="hd_h_ml302.tu2_1_4_1_2" id="hd_h_ml302.tu2_1_4_2_14" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">BL21</th><th headers="hd_h_ml302.tu2_1_4_1_3" id="hd_h_ml302.tu2_1_4_2_15" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">VIM-2</th><th headers="hd_h_ml302.tu2_1_4_1_3" id="hd_h_ml302.tu2_1_4_2_16" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">IMP-1</th><th headers="hd_h_ml302.tu2_1_4_1_3" id="hd_h_ml302.tu2_1_4_2_17" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">VIM-2 Ki</th></tr><tr><th headers="hd_h_ml302.tu2_1_4_1_2 hd_h_ml302.tu2_1_4_2_9" id="hd_h_ml302.tu2_1_4_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">MIC 4× (μM)</th><th headers="hd_h_ml302.tu2_1_4_1_2 hd_h_ml302.tu2_1_4_2_9" id="hd_h_ml302.tu2_1_4_3_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Imipenem Potentiation</th><th headers="hd_h_ml302.tu2_1_4_1_2 hd_h_ml302.tu2_1_4_2_10" id="hd_h_ml302.tu2_1_4_3_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">MIC 4× (μM)</th><th headers="hd_h_ml302.tu2_1_4_1_2 hd_h_ml302.tu2_1_4_2_10" id="hd_h_ml302.tu2_1_4_3_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Imipenem Potentiation</th><th headers="hd_h_ml302.tu2_1_4_1_2 hd_h_ml302.tu2_1_4_2_11" id="hd_h_ml302.tu2_1_4_3_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">MIC 4× (μM)</th><th headers="hd_h_ml302.tu2_1_4_1_2 hd_h_ml302.tu2_1_4_2_11" id="hd_h_ml302.tu2_1_4_3_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Imipenem Potentiation</th><th headers="hd_h_ml302.tu2_1_4_1_2 hd_h_ml302.tu2_1_4_2_12" id="hd_h_ml302.tu2_1_4_3_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">MIC 4× (μM)</th><th headers="hd_h_ml302.tu2_1_4_1_2 hd_h_ml302.tu2_1_4_2_12" id="hd_h_ml302.tu2_1_4_3_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Imipenem Potentiation</th><th headers="hd_h_ml302.tu2_1_4_1_2 hd_h_ml302.tu2_1_4_2_13" id="hd_h_ml302.tu2_1_4_3_9" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">MIC 4× (μM)</th><th headers="hd_h_ml302.tu2_1_4_1_2 hd_h_ml302.tu2_1_4_2_14" id="hd_h_ml302.tu2_1_4_3_10" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">MIC 4× (μM)</th><th headers="hd_h_ml302.tu2_1_4_1_3 hd_h_ml302.tu2_1_4_2_15" id="hd_h_ml302.tu2_1_4_3_11" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">IC50 (uM)</th><th headers="hd_h_ml302.tu2_1_4_1_3 hd_h_ml302.tu2_1_4_2_16" id="hd_h_ml302.tu2_1_4_3_12" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">IC50 (uM)</th><th headers="hd_h_ml302.tu2_1_4_1_3 hd_h_ml302.tu2_1_4_2_17" id="hd_h_ml302.tu2_1_4_3_13" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Ki (nM)</th></tr></thead><tbody><tr><td headers="hd_h_ml302.tu2_1_4_1_1 hd_h_ml302.tu2_1_4_2_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Analog 20</td><td headers="hd_h_ml302.tu2_1_4_1_1 hd_h_ml302.tu2_1_4_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-03000002455-1</td><td headers="hd_h_ml302.tu2_1_4_1_1 hd_h_ml302.tu2_1_4_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">
|
||
<div class="graphic"><img src="/books/NBK143563/bin/ml302fu22.jpg" alt="Image ml302fu22.jpg" /></div></td><td headers="hd_h_ml302.tu2_1_4_1_1 hd_h_ml302.tu2_1_4_2_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">2049116</td><td headers="hd_h_ml302.tu2_1_4_1_1 hd_h_ml302.tu2_1_4_2_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/125001873" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">125001873</a></td><td headers="hd_h_ml302.tu2_1_4_1_1 hd_h_ml302.tu2_1_4_2_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_4_1_1 hd_h_ml302.tu2_1_4_2_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Innovapharm Ltd.</td><td headers="hd_h_ml302.tu2_1_4_1_1 hd_h_ml302.tu2_1_4_2_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">STT-00175051</td><td headers="hd_h_ml302.tu2_1_4_1_2 hd_h_ml302.tu2_1_4_2_9 hd_h_ml302.tu2_1_4_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">>100</td><td headers="hd_h_ml302.tu2_1_4_1_2 hd_h_ml302.tu2_1_4_2_9 hd_h_ml302.tu2_1_4_3_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_4_1_2 hd_h_ml302.tu2_1_4_2_10 hd_h_ml302.tu2_1_4_3_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_4_1_2 hd_h_ml302.tu2_1_4_2_10 hd_h_ml302.tu2_1_4_3_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_4_1_2 hd_h_ml302.tu2_1_4_2_11 hd_h_ml302.tu2_1_4_3_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_4_1_2 hd_h_ml302.tu2_1_4_2_11 hd_h_ml302.tu2_1_4_3_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_4_1_2 hd_h_ml302.tu2_1_4_2_12 hd_h_ml302.tu2_1_4_3_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_4_1_2 hd_h_ml302.tu2_1_4_2_12 hd_h_ml302.tu2_1_4_3_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_4_1_2 hd_h_ml302.tu2_1_4_2_13 hd_h_ml302.tu2_1_4_3_9" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_4_1_2 hd_h_ml302.tu2_1_4_2_14 hd_h_ml302.tu2_1_4_3_10" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_4_1_3 hd_h_ml302.tu2_1_4_2_15 hd_h_ml302.tu2_1_4_3_11" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_4_1_3 hd_h_ml302.tu2_1_4_2_16 hd_h_ml302.tu2_1_4_3_12" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_4_1_3 hd_h_ml302.tu2_1_4_2_17 hd_h_ml302.tu2_1_4_3_13" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td></tr><tr><td headers="hd_h_ml302.tu2_1_4_1_1 hd_h_ml302.tu2_1_4_2_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Analog 21</td><td headers="hd_h_ml302.tu2_1_4_1_1 hd_h_ml302.tu2_1_4_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-03000002460-1</td><td headers="hd_h_ml302.tu2_1_4_1_1 hd_h_ml302.tu2_1_4_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">
|
||
<div class="graphic"><img src="/books/NBK143563/bin/ml302fu23.jpg" alt="Image ml302fu23.jpg" /></div></td><td headers="hd_h_ml302.tu2_1_4_1_1 hd_h_ml302.tu2_1_4_2_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">5724963</td><td headers="hd_h_ml302.tu2_1_4_1_1 hd_h_ml302.tu2_1_4_2_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/125001879" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">125001879</a></td><td headers="hd_h_ml302.tu2_1_4_1_1 hd_h_ml302.tu2_1_4_2_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_4_1_1 hd_h_ml302.tu2_1_4_2_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Vitas-M Lab</td><td headers="hd_h_ml302.tu2_1_4_1_1 hd_h_ml302.tu2_1_4_2_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">STL035210</td><td headers="hd_h_ml302.tu2_1_4_1_2 hd_h_ml302.tu2_1_4_2_9 hd_h_ml302.tu2_1_4_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">3.13</td><td headers="hd_h_ml302.tu2_1_4_1_2 hd_h_ml302.tu2_1_4_2_9 hd_h_ml302.tu2_1_4_3_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_4_1_2 hd_h_ml302.tu2_1_4_2_10 hd_h_ml302.tu2_1_4_3_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">50</td><td headers="hd_h_ml302.tu2_1_4_1_2 hd_h_ml302.tu2_1_4_2_10 hd_h_ml302.tu2_1_4_3_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_4_1_2 hd_h_ml302.tu2_1_4_2_11 hd_h_ml302.tu2_1_4_3_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_4_1_2 hd_h_ml302.tu2_1_4_2_11 hd_h_ml302.tu2_1_4_3_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_4_1_2 hd_h_ml302.tu2_1_4_2_12 hd_h_ml302.tu2_1_4_3_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_4_1_2 hd_h_ml302.tu2_1_4_2_12 hd_h_ml302.tu2_1_4_3_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_4_1_2 hd_h_ml302.tu2_1_4_2_13 hd_h_ml302.tu2_1_4_3_9" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_4_1_2 hd_h_ml302.tu2_1_4_2_14 hd_h_ml302.tu2_1_4_3_10" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_4_1_3 hd_h_ml302.tu2_1_4_2_15 hd_h_ml302.tu2_1_4_3_11" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_4_1_3 hd_h_ml302.tu2_1_4_2_16 hd_h_ml302.tu2_1_4_3_12" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_4_1_3 hd_h_ml302.tu2_1_4_2_17 hd_h_ml302.tu2_1_4_3_13" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td></tr><tr><td headers="hd_h_ml302.tu2_1_4_1_1 hd_h_ml302.tu2_1_4_2_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Analog 22</td><td headers="hd_h_ml302.tu2_1_4_1_1 hd_h_ml302.tu2_1_4_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-03000002385-1</td><td headers="hd_h_ml302.tu2_1_4_1_1 hd_h_ml302.tu2_1_4_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">
|
||
<div class="graphic"><img src="/books/NBK143563/bin/ml302fu24.jpg" alt="Image ml302fu24.jpg" /></div></td><td headers="hd_h_ml302.tu2_1_4_1_1 hd_h_ml302.tu2_1_4_2_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">53301880</td><td headers="hd_h_ml302.tu2_1_4_1_1 hd_h_ml302.tu2_1_4_2_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/124756519" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">124756519</a></td><td headers="hd_h_ml302.tu2_1_4_1_1 hd_h_ml302.tu2_1_4_2_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_4_1_1 hd_h_ml302.tu2_1_4_2_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">TSRI</td><td headers="hd_h_ml302.tu2_1_4_1_1 hd_h_ml302.tu2_1_4_2_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">None</td><td headers="hd_h_ml302.tu2_1_4_1_2 hd_h_ml302.tu2_1_4_2_9 hd_h_ml302.tu2_1_4_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">25</td><td headers="hd_h_ml302.tu2_1_4_1_2 hd_h_ml302.tu2_1_4_2_9 hd_h_ml302.tu2_1_4_3_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_4_1_2 hd_h_ml302.tu2_1_4_2_10 hd_h_ml302.tu2_1_4_3_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_4_1_2 hd_h_ml302.tu2_1_4_2_10 hd_h_ml302.tu2_1_4_3_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_4_1_2 hd_h_ml302.tu2_1_4_2_11 hd_h_ml302.tu2_1_4_3_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_4_1_2 hd_h_ml302.tu2_1_4_2_11 hd_h_ml302.tu2_1_4_3_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_4_1_2 hd_h_ml302.tu2_1_4_2_12 hd_h_ml302.tu2_1_4_3_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_4_1_2 hd_h_ml302.tu2_1_4_2_12 hd_h_ml302.tu2_1_4_3_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_4_1_2 hd_h_ml302.tu2_1_4_2_13 hd_h_ml302.tu2_1_4_3_9" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_4_1_2 hd_h_ml302.tu2_1_4_2_14 hd_h_ml302.tu2_1_4_3_10" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_4_1_3 hd_h_ml302.tu2_1_4_2_15 hd_h_ml302.tu2_1_4_3_11" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_4_1_3 hd_h_ml302.tu2_1_4_2_16 hd_h_ml302.tu2_1_4_3_12" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_4_1_3 hd_h_ml302.tu2_1_4_2_17 hd_h_ml302.tu2_1_4_3_13" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td></tr><tr><td headers="hd_h_ml302.tu2_1_4_1_1 hd_h_ml302.tu2_1_4_2_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Analog 23</td><td headers="hd_h_ml302.tu2_1_4_1_1 hd_h_ml302.tu2_1_4_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-03000002386-1</td><td headers="hd_h_ml302.tu2_1_4_1_1 hd_h_ml302.tu2_1_4_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">
|
||
<div class="graphic"><img src="/books/NBK143563/bin/ml302fu25.jpg" alt="Image ml302fu25.jpg" /></div></td><td headers="hd_h_ml302.tu2_1_4_1_1 hd_h_ml302.tu2_1_4_2_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">53301896</td><td headers="hd_h_ml302.tu2_1_4_1_1 hd_h_ml302.tu2_1_4_2_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/124756520" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">124756520</a></td><td headers="hd_h_ml302.tu2_1_4_1_1 hd_h_ml302.tu2_1_4_2_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_4_1_1 hd_h_ml302.tu2_1_4_2_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">TSRI</td><td headers="hd_h_ml302.tu2_1_4_1_1 hd_h_ml302.tu2_1_4_2_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">None</td><td headers="hd_h_ml302.tu2_1_4_1_2 hd_h_ml302.tu2_1_4_2_9 hd_h_ml302.tu2_1_4_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">>100</td><td headers="hd_h_ml302.tu2_1_4_1_2 hd_h_ml302.tu2_1_4_2_9 hd_h_ml302.tu2_1_4_3_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_4_1_2 hd_h_ml302.tu2_1_4_2_10 hd_h_ml302.tu2_1_4_3_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_4_1_2 hd_h_ml302.tu2_1_4_2_10 hd_h_ml302.tu2_1_4_3_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_4_1_2 hd_h_ml302.tu2_1_4_2_11 hd_h_ml302.tu2_1_4_3_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_4_1_2 hd_h_ml302.tu2_1_4_2_11 hd_h_ml302.tu2_1_4_3_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_4_1_2 hd_h_ml302.tu2_1_4_2_12 hd_h_ml302.tu2_1_4_3_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_4_1_2 hd_h_ml302.tu2_1_4_2_12 hd_h_ml302.tu2_1_4_3_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_4_1_2 hd_h_ml302.tu2_1_4_2_13 hd_h_ml302.tu2_1_4_3_9" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_4_1_2 hd_h_ml302.tu2_1_4_2_14 hd_h_ml302.tu2_1_4_3_10" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_4_1_3 hd_h_ml302.tu2_1_4_2_15 hd_h_ml302.tu2_1_4_3_11" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_4_1_3 hd_h_ml302.tu2_1_4_2_16 hd_h_ml302.tu2_1_4_3_12" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_4_1_3 hd_h_ml302.tu2_1_4_2_17 hd_h_ml302.tu2_1_4_3_13" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td></tr><tr><td headers="hd_h_ml302.tu2_1_4_1_1 hd_h_ml302.tu2_1_4_2_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Analog 24</td><td headers="hd_h_ml302.tu2_1_4_1_1 hd_h_ml302.tu2_1_4_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-03000002398-1</td><td headers="hd_h_ml302.tu2_1_4_1_1 hd_h_ml302.tu2_1_4_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">
|
||
<div class="graphic"><img src="/books/NBK143563/bin/ml302fu26.jpg" alt="Image ml302fu26.jpg" /></div></td><td headers="hd_h_ml302.tu2_1_4_1_1 hd_h_ml302.tu2_1_4_2_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">53301889</td><td headers="hd_h_ml302.tu2_1_4_1_1 hd_h_ml302.tu2_1_4_2_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/124756533" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">124756533</a></td><td headers="hd_h_ml302.tu2_1_4_1_1 hd_h_ml302.tu2_1_4_2_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_4_1_1 hd_h_ml302.tu2_1_4_2_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">TSRI</td><td headers="hd_h_ml302.tu2_1_4_1_1 hd_h_ml302.tu2_1_4_2_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">None</td><td headers="hd_h_ml302.tu2_1_4_1_2 hd_h_ml302.tu2_1_4_2_9 hd_h_ml302.tu2_1_4_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">>100</td><td headers="hd_h_ml302.tu2_1_4_1_2 hd_h_ml302.tu2_1_4_2_9 hd_h_ml302.tu2_1_4_3_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_4_1_2 hd_h_ml302.tu2_1_4_2_10 hd_h_ml302.tu2_1_4_3_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_4_1_2 hd_h_ml302.tu2_1_4_2_10 hd_h_ml302.tu2_1_4_3_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_4_1_2 hd_h_ml302.tu2_1_4_2_11 hd_h_ml302.tu2_1_4_3_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_4_1_2 hd_h_ml302.tu2_1_4_2_11 hd_h_ml302.tu2_1_4_3_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_4_1_2 hd_h_ml302.tu2_1_4_2_12 hd_h_ml302.tu2_1_4_3_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_4_1_2 hd_h_ml302.tu2_1_4_2_12 hd_h_ml302.tu2_1_4_3_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_4_1_2 hd_h_ml302.tu2_1_4_2_13 hd_h_ml302.tu2_1_4_3_9" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_4_1_2 hd_h_ml302.tu2_1_4_2_14 hd_h_ml302.tu2_1_4_3_10" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_4_1_3 hd_h_ml302.tu2_1_4_2_15 hd_h_ml302.tu2_1_4_3_11" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_4_1_3 hd_h_ml302.tu2_1_4_2_16 hd_h_ml302.tu2_1_4_3_12" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_4_1_3 hd_h_ml302.tu2_1_4_2_17 hd_h_ml302.tu2_1_4_3_13" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td></tr><tr><td headers="hd_h_ml302.tu2_1_4_1_1 hd_h_ml302.tu2_1_4_2_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Analog 25</td><td headers="hd_h_ml302.tu2_1_4_1_1 hd_h_ml302.tu2_1_4_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-03000002447-1</td><td headers="hd_h_ml302.tu2_1_4_1_1 hd_h_ml302.tu2_1_4_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">
|
||
<div class="graphic"><img src="/books/NBK143563/bin/ml302fu27.jpg" alt="Image ml302fu27.jpg" /></div></td><td headers="hd_h_ml302.tu2_1_4_1_1 hd_h_ml302.tu2_1_4_2_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">53313357</td><td headers="hd_h_ml302.tu2_1_4_1_1 hd_h_ml302.tu2_1_4_2_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/124807342" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">124807342</a></td><td headers="hd_h_ml302.tu2_1_4_1_1 hd_h_ml302.tu2_1_4_2_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_4_1_1 hd_h_ml302.tu2_1_4_2_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">TSRI</td><td headers="hd_h_ml302.tu2_1_4_1_1 hd_h_ml302.tu2_1_4_2_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">None</td><td headers="hd_h_ml302.tu2_1_4_1_2 hd_h_ml302.tu2_1_4_2_9 hd_h_ml302.tu2_1_4_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">>100</td><td headers="hd_h_ml302.tu2_1_4_1_2 hd_h_ml302.tu2_1_4_2_9 hd_h_ml302.tu2_1_4_3_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_4_1_2 hd_h_ml302.tu2_1_4_2_10 hd_h_ml302.tu2_1_4_3_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_4_1_2 hd_h_ml302.tu2_1_4_2_10 hd_h_ml302.tu2_1_4_3_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_4_1_2 hd_h_ml302.tu2_1_4_2_11 hd_h_ml302.tu2_1_4_3_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_4_1_2 hd_h_ml302.tu2_1_4_2_11 hd_h_ml302.tu2_1_4_3_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_4_1_2 hd_h_ml302.tu2_1_4_2_12 hd_h_ml302.tu2_1_4_3_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_4_1_2 hd_h_ml302.tu2_1_4_2_12 hd_h_ml302.tu2_1_4_3_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_4_1_2 hd_h_ml302.tu2_1_4_2_13 hd_h_ml302.tu2_1_4_3_9" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_4_1_2 hd_h_ml302.tu2_1_4_2_14 hd_h_ml302.tu2_1_4_3_10" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_4_1_3 hd_h_ml302.tu2_1_4_2_15 hd_h_ml302.tu2_1_4_3_11" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_4_1_3 hd_h_ml302.tu2_1_4_2_16 hd_h_ml302.tu2_1_4_3_12" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_4_1_3 hd_h_ml302.tu2_1_4_2_17 hd_h_ml302.tu2_1_4_3_13" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td></tr><tr><td headers="hd_h_ml302.tu2_1_4_1_1 hd_h_ml302.tu2_1_4_2_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Analog 26</td><td headers="hd_h_ml302.tu2_1_4_1_1 hd_h_ml302.tu2_1_4_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-03000002448-1</td><td headers="hd_h_ml302.tu2_1_4_1_1 hd_h_ml302.tu2_1_4_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">
|
||
<div class="graphic"><img src="/books/NBK143563/bin/ml302fu28.jpg" alt="Image ml302fu28.jpg" /></div></td><td headers="hd_h_ml302.tu2_1_4_1_1 hd_h_ml302.tu2_1_4_2_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">53313358</td><td headers="hd_h_ml302.tu2_1_4_1_1 hd_h_ml302.tu2_1_4_2_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/124807343" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">124807343</a></td><td headers="hd_h_ml302.tu2_1_4_1_1 hd_h_ml302.tu2_1_4_2_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_4_1_1 hd_h_ml302.tu2_1_4_2_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">TSRI</td><td headers="hd_h_ml302.tu2_1_4_1_1 hd_h_ml302.tu2_1_4_2_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">None</td><td headers="hd_h_ml302.tu2_1_4_1_2 hd_h_ml302.tu2_1_4_2_9 hd_h_ml302.tu2_1_4_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">>100</td><td headers="hd_h_ml302.tu2_1_4_1_2 hd_h_ml302.tu2_1_4_2_9 hd_h_ml302.tu2_1_4_3_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_4_1_2 hd_h_ml302.tu2_1_4_2_10 hd_h_ml302.tu2_1_4_3_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_4_1_2 hd_h_ml302.tu2_1_4_2_10 hd_h_ml302.tu2_1_4_3_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_4_1_2 hd_h_ml302.tu2_1_4_2_11 hd_h_ml302.tu2_1_4_3_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_4_1_2 hd_h_ml302.tu2_1_4_2_11 hd_h_ml302.tu2_1_4_3_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_4_1_2 hd_h_ml302.tu2_1_4_2_12 hd_h_ml302.tu2_1_4_3_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_4_1_2 hd_h_ml302.tu2_1_4_2_12 hd_h_ml302.tu2_1_4_3_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_4_1_2 hd_h_ml302.tu2_1_4_2_13 hd_h_ml302.tu2_1_4_3_9" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_4_1_2 hd_h_ml302.tu2_1_4_2_14 hd_h_ml302.tu2_1_4_3_10" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_4_1_3 hd_h_ml302.tu2_1_4_2_15 hd_h_ml302.tu2_1_4_3_11" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_4_1_3 hd_h_ml302.tu2_1_4_2_16 hd_h_ml302.tu2_1_4_3_12" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_4_1_3 hd_h_ml302.tu2_1_4_2_17 hd_h_ml302.tu2_1_4_3_13" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td></tr><tr><td headers="hd_h_ml302.tu2_1_4_1_1 hd_h_ml302.tu2_1_4_2_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Analog 27</td><td headers="hd_h_ml302.tu2_1_4_1_1 hd_h_ml302.tu2_1_4_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-03000002457-1</td><td headers="hd_h_ml302.tu2_1_4_1_1 hd_h_ml302.tu2_1_4_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">
|
||
<div class="graphic"><img src="/books/NBK143563/bin/ml302fu29.jpg" alt="Image ml302fu29.jpg" /></div></td><td headers="hd_h_ml302.tu2_1_4_1_1 hd_h_ml302.tu2_1_4_2_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">17592954</td><td headers="hd_h_ml302.tu2_1_4_1_1 hd_h_ml302.tu2_1_4_2_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/125001875" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">125001875</a></td><td headers="hd_h_ml302.tu2_1_4_1_1 hd_h_ml302.tu2_1_4_2_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_4_1_1 hd_h_ml302.tu2_1_4_2_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Vitas-M Lab</td><td headers="hd_h_ml302.tu2_1_4_1_1 hd_h_ml302.tu2_1_4_2_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">STK626562</td><td headers="hd_h_ml302.tu2_1_4_1_2 hd_h_ml302.tu2_1_4_2_9 hd_h_ml302.tu2_1_4_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">100</td><td headers="hd_h_ml302.tu2_1_4_1_2 hd_h_ml302.tu2_1_4_2_9 hd_h_ml302.tu2_1_4_3_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_4_1_2 hd_h_ml302.tu2_1_4_2_10 hd_h_ml302.tu2_1_4_3_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_4_1_2 hd_h_ml302.tu2_1_4_2_10 hd_h_ml302.tu2_1_4_3_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_4_1_2 hd_h_ml302.tu2_1_4_2_11 hd_h_ml302.tu2_1_4_3_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_4_1_2 hd_h_ml302.tu2_1_4_2_11 hd_h_ml302.tu2_1_4_3_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_4_1_2 hd_h_ml302.tu2_1_4_2_12 hd_h_ml302.tu2_1_4_3_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_4_1_2 hd_h_ml302.tu2_1_4_2_12 hd_h_ml302.tu2_1_4_3_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_4_1_2 hd_h_ml302.tu2_1_4_2_13 hd_h_ml302.tu2_1_4_3_9" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_4_1_2 hd_h_ml302.tu2_1_4_2_14 hd_h_ml302.tu2_1_4_3_10" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_4_1_3 hd_h_ml302.tu2_1_4_2_15 hd_h_ml302.tu2_1_4_3_11" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_4_1_3 hd_h_ml302.tu2_1_4_2_16 hd_h_ml302.tu2_1_4_3_12" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_4_1_3 hd_h_ml302.tu2_1_4_2_17 hd_h_ml302.tu2_1_4_3_13" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td></tr><tr><td headers="hd_h_ml302.tu2_1_4_1_1 hd_h_ml302.tu2_1_4_2_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Analog 28</td><td headers="hd_h_ml302.tu2_1_4_1_1 hd_h_ml302.tu2_1_4_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-03000002459-1</td><td headers="hd_h_ml302.tu2_1_4_1_1 hd_h_ml302.tu2_1_4_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">
|
||
<div class="graphic"><img src="/books/NBK143563/bin/ml302fu30.jpg" alt="Image ml302fu30.jpg" /></div></td><td headers="hd_h_ml302.tu2_1_4_1_1 hd_h_ml302.tu2_1_4_2_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">50739720</td><td headers="hd_h_ml302.tu2_1_4_1_1 hd_h_ml302.tu2_1_4_2_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/125001877" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">125001877</a></td><td headers="hd_h_ml302.tu2_1_4_1_1 hd_h_ml302.tu2_1_4_2_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_4_1_1 hd_h_ml302.tu2_1_4_2_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Innovapharm Ltd.</td><td headers="hd_h_ml302.tu2_1_4_1_1 hd_h_ml302.tu2_1_4_2_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">STT-00362432</td><td headers="hd_h_ml302.tu2_1_4_1_2 hd_h_ml302.tu2_1_4_2_9 hd_h_ml302.tu2_1_4_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">100</td><td headers="hd_h_ml302.tu2_1_4_1_2 hd_h_ml302.tu2_1_4_2_9 hd_h_ml302.tu2_1_4_3_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_4_1_2 hd_h_ml302.tu2_1_4_2_10 hd_h_ml302.tu2_1_4_3_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_4_1_2 hd_h_ml302.tu2_1_4_2_10 hd_h_ml302.tu2_1_4_3_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_4_1_2 hd_h_ml302.tu2_1_4_2_11 hd_h_ml302.tu2_1_4_3_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_4_1_2 hd_h_ml302.tu2_1_4_2_11 hd_h_ml302.tu2_1_4_3_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_4_1_2 hd_h_ml302.tu2_1_4_2_12 hd_h_ml302.tu2_1_4_3_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_4_1_2 hd_h_ml302.tu2_1_4_2_12 hd_h_ml302.tu2_1_4_3_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_4_1_2 hd_h_ml302.tu2_1_4_2_13 hd_h_ml302.tu2_1_4_3_9" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_4_1_2 hd_h_ml302.tu2_1_4_2_14 hd_h_ml302.tu2_1_4_3_10" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_4_1_3 hd_h_ml302.tu2_1_4_2_15 hd_h_ml302.tu2_1_4_3_11" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_4_1_3 hd_h_ml302.tu2_1_4_2_16 hd_h_ml302.tu2_1_4_3_12" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_4_1_3 hd_h_ml302.tu2_1_4_2_17 hd_h_ml302.tu2_1_4_3_13" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td></tr><tr><td headers="hd_h_ml302.tu2_1_4_1_1 hd_h_ml302.tu2_1_4_2_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Analog 29</td><td headers="hd_h_ml302.tu2_1_4_1_1 hd_h_ml302.tu2_1_4_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-00000009750-1</td><td headers="hd_h_ml302.tu2_1_4_1_1 hd_h_ml302.tu2_1_4_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">
|
||
<div class="graphic"><img src="/books/NBK143563/bin/ml302fu31.jpg" alt="Image ml302fu31.jpg" /></div></td><td headers="hd_h_ml302.tu2_1_4_1_1 hd_h_ml302.tu2_1_4_2_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">53308608</td><td headers="hd_h_ml302.tu2_1_4_1_1 hd_h_ml302.tu2_1_4_2_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/124767339" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">124767339</a></td><td headers="hd_h_ml302.tu2_1_4_1_1 hd_h_ml302.tu2_1_4_2_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_4_1_1 hd_h_ml302.tu2_1_4_2_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">TSRI</td><td headers="hd_h_ml302.tu2_1_4_1_1 hd_h_ml302.tu2_1_4_2_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">None</td><td headers="hd_h_ml302.tu2_1_4_1_2 hd_h_ml302.tu2_1_4_2_9 hd_h_ml302.tu2_1_4_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">>100</td><td headers="hd_h_ml302.tu2_1_4_1_2 hd_h_ml302.tu2_1_4_2_9 hd_h_ml302.tu2_1_4_3_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_4_1_2 hd_h_ml302.tu2_1_4_2_10 hd_h_ml302.tu2_1_4_3_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_4_1_2 hd_h_ml302.tu2_1_4_2_10 hd_h_ml302.tu2_1_4_3_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_4_1_2 hd_h_ml302.tu2_1_4_2_11 hd_h_ml302.tu2_1_4_3_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_4_1_2 hd_h_ml302.tu2_1_4_2_11 hd_h_ml302.tu2_1_4_3_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_4_1_2 hd_h_ml302.tu2_1_4_2_12 hd_h_ml302.tu2_1_4_3_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_4_1_2 hd_h_ml302.tu2_1_4_2_12 hd_h_ml302.tu2_1_4_3_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_4_1_2 hd_h_ml302.tu2_1_4_2_13 hd_h_ml302.tu2_1_4_3_9" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_4_1_2 hd_h_ml302.tu2_1_4_2_14 hd_h_ml302.tu2_1_4_3_10" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_4_1_3 hd_h_ml302.tu2_1_4_2_15 hd_h_ml302.tu2_1_4_3_11" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_4_1_3 hd_h_ml302.tu2_1_4_2_16 hd_h_ml302.tu2_1_4_3_12" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_4_1_3 hd_h_ml302.tu2_1_4_2_17 hd_h_ml302.tu2_1_4_3_13" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td></tr></tbody></table><table><thead><tr><th id="hd_h_ml302.tu2_1_5_1_1" colspan="8" rowspan="1" style="text-align:center;vertical-align:middle;">Compound Information</th><th id="hd_h_ml302.tu2_1_5_1_2" colspan="4" rowspan="1" style="text-align:center;vertical-align:middle;">Bacterial Assays (Strain and MBL)</th></tr><tr><th headers="hd_h_ml302.tu2_1_5_1_1 hd_h_ml302.tu2_1_5_2_1" id="hd_h_ml302.tu2_1_5_2_1" rowspan="2" colspan="1" style="text-align:center;vertical-align:middle;">Compound</th><th headers="hd_h_ml302.tu2_1_5_1_1 hd_h_ml302.tu2_1_5_2_2" id="hd_h_ml302.tu2_1_5_2_2" rowspan="2" colspan="1" style="text-align:center;vertical-align:middle;">SR-Number</th><th headers="hd_h_ml302.tu2_1_5_1_1 hd_h_ml302.tu2_1_5_2_3" id="hd_h_ml302.tu2_1_5_2_3" rowspan="2" colspan="1" style="text-align:center;vertical-align:middle;">Structure</th><th headers="hd_h_ml302.tu2_1_5_1_1 hd_h_ml302.tu2_1_5_2_4" id="hd_h_ml302.tu2_1_5_2_4" rowspan="2" colspan="1" style="text-align:center;vertical-align:middle;">CID</th><th headers="hd_h_ml302.tu2_1_5_1_1 hd_h_ml302.tu2_1_5_2_5" id="hd_h_ml302.tu2_1_5_2_5" rowspan="2" colspan="1" style="text-align:center;vertical-align:middle;">SID</th><th headers="hd_h_ml302.tu2_1_5_1_1 hd_h_ml302.tu2_1_5_2_6" id="hd_h_ml302.tu2_1_5_2_6" rowspan="2" colspan="1" style="text-align:center;vertical-align:middle;">MLS</th><th headers="hd_h_ml302.tu2_1_5_1_1 hd_h_ml302.tu2_1_5_2_7" id="hd_h_ml302.tu2_1_5_2_7" rowspan="2" colspan="1" style="text-align:center;vertical-align:middle;">Vendor</th><th headers="hd_h_ml302.tu2_1_5_1_1 hd_h_ml302.tu2_1_5_2_8" id="hd_h_ml302.tu2_1_5_2_8" rowspan="2" colspan="1" style="text-align:center;vertical-align:middle;">Vendor Catalog ID</th><th headers="hd_h_ml302.tu2_1_5_1_2" id="hd_h_ml302.tu2_1_5_2_9" colspan="2" rowspan="1" style="text-align:center;vertical-align:middle;">BL21 (VIM-2)</th><th headers="hd_h_ml302.tu2_1_5_1_2" id="hd_h_ml302.tu2_1_5_2_10" colspan="2" rowspan="1" style="text-align:center;vertical-align:middle;">YMC07/B3323 (VIM-2)</th></tr><tr><th headers="hd_h_ml302.tu2_1_5_1_2 hd_h_ml302.tu2_1_5_2_9" id="hd_h_ml302.tu2_1_5_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">MIC 4× (μM)</th><th headers="hd_h_ml302.tu2_1_5_1_2 hd_h_ml302.tu2_1_5_2_9" id="hd_h_ml302.tu2_1_5_3_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Imipenem Potentiation</th><th headers="hd_h_ml302.tu2_1_5_1_2 hd_h_ml302.tu2_1_5_2_10" id="hd_h_ml302.tu2_1_5_3_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">MIC 4× (μM)</th><th headers="hd_h_ml302.tu2_1_5_1_2 hd_h_ml302.tu2_1_5_2_10" id="hd_h_ml302.tu2_1_5_3_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Imipenem Potentiation</th></tr></thead><tbody><tr><td headers="hd_h_ml302.tu2_1_5_1_1 hd_h_ml302.tu2_1_5_2_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Analog 30</td><td headers="hd_h_ml302.tu2_1_5_1_1 hd_h_ml302.tu2_1_5_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-03000002382-1</td><td headers="hd_h_ml302.tu2_1_5_1_1 hd_h_ml302.tu2_1_5_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">
|
||
<div class="graphic"><img src="/books/NBK143563/bin/ml302fu32.jpg" alt="Image ml302fu32.jpg" /></div></td><td headers="hd_h_ml302.tu2_1_5_1_1 hd_h_ml302.tu2_1_5_2_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">53257017</td><td headers="hd_h_ml302.tu2_1_5_1_1 hd_h_ml302.tu2_1_5_2_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/124398405" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">124398405</a></td><td headers="hd_h_ml302.tu2_1_5_1_1 hd_h_ml302.tu2_1_5_2_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_5_1_1 hd_h_ml302.tu2_1_5_2_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">TSRI</td><td headers="hd_h_ml302.tu2_1_5_1_1 hd_h_ml302.tu2_1_5_2_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">None</td><td headers="hd_h_ml302.tu2_1_5_1_2 hd_h_ml302.tu2_1_5_2_9 hd_h_ml302.tu2_1_5_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">12.5</td><td headers="hd_h_ml302.tu2_1_5_1_2 hd_h_ml302.tu2_1_5_2_9 hd_h_ml302.tu2_1_5_3_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">8X</td><td headers="hd_h_ml302.tu2_1_5_1_2 hd_h_ml302.tu2_1_5_2_10 hd_h_ml302.tu2_1_5_3_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">6.25</td><td headers="hd_h_ml302.tu2_1_5_1_2 hd_h_ml302.tu2_1_5_2_10 hd_h_ml302.tu2_1_5_3_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">16X</td></tr><tr><td headers="hd_h_ml302.tu2_1_5_1_1 hd_h_ml302.tu2_1_5_2_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Analog 31</td><td headers="hd_h_ml302.tu2_1_5_1_1 hd_h_ml302.tu2_1_5_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-03000002383-1</td><td headers="hd_h_ml302.tu2_1_5_1_1 hd_h_ml302.tu2_1_5_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">
|
||
<div class="graphic"><img src="/books/NBK143563/bin/ml302fu33.jpg" alt="Image ml302fu33.jpg" /></div></td><td headers="hd_h_ml302.tu2_1_5_1_1 hd_h_ml302.tu2_1_5_2_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">53301893</td><td headers="hd_h_ml302.tu2_1_5_1_1 hd_h_ml302.tu2_1_5_2_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/124756517" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">124756517</a></td><td headers="hd_h_ml302.tu2_1_5_1_1 hd_h_ml302.tu2_1_5_2_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_5_1_1 hd_h_ml302.tu2_1_5_2_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">TSRI</td><td headers="hd_h_ml302.tu2_1_5_1_1 hd_h_ml302.tu2_1_5_2_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">None</td><td headers="hd_h_ml302.tu2_1_5_1_2 hd_h_ml302.tu2_1_5_2_9 hd_h_ml302.tu2_1_5_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">12.5</td><td headers="hd_h_ml302.tu2_1_5_1_2 hd_h_ml302.tu2_1_5_2_9 hd_h_ml302.tu2_1_5_3_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">8X</td><td headers="hd_h_ml302.tu2_1_5_1_2 hd_h_ml302.tu2_1_5_2_10 hd_h_ml302.tu2_1_5_3_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_5_1_2 hd_h_ml302.tu2_1_5_2_10 hd_h_ml302.tu2_1_5_3_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td></tr><tr><td headers="hd_h_ml302.tu2_1_5_1_1 hd_h_ml302.tu2_1_5_2_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Analog 32</td><td headers="hd_h_ml302.tu2_1_5_1_1 hd_h_ml302.tu2_1_5_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-03000002432-1</td><td headers="hd_h_ml302.tu2_1_5_1_1 hd_h_ml302.tu2_1_5_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">
|
||
<div class="graphic"><img src="/books/NBK143563/bin/ml302fu34.jpg" alt="Image ml302fu34.jpg" /></div></td><td headers="hd_h_ml302.tu2_1_5_1_1 hd_h_ml302.tu2_1_5_2_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">53308616</td><td headers="hd_h_ml302.tu2_1_5_1_1 hd_h_ml302.tu2_1_5_2_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/124767336" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">124767336</a></td><td headers="hd_h_ml302.tu2_1_5_1_1 hd_h_ml302.tu2_1_5_2_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_5_1_1 hd_h_ml302.tu2_1_5_2_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">TSRI</td><td headers="hd_h_ml302.tu2_1_5_1_1 hd_h_ml302.tu2_1_5_2_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">None</td><td headers="hd_h_ml302.tu2_1_5_1_2 hd_h_ml302.tu2_1_5_2_9 hd_h_ml302.tu2_1_5_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">>100</td><td headers="hd_h_ml302.tu2_1_5_1_2 hd_h_ml302.tu2_1_5_2_9 hd_h_ml302.tu2_1_5_3_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_5_1_2 hd_h_ml302.tu2_1_5_2_10 hd_h_ml302.tu2_1_5_3_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_5_1_2 hd_h_ml302.tu2_1_5_2_10 hd_h_ml302.tu2_1_5_3_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td></tr><tr><td headers="hd_h_ml302.tu2_1_5_1_1 hd_h_ml302.tu2_1_5_2_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Analog 33</td><td headers="hd_h_ml302.tu2_1_5_1_1 hd_h_ml302.tu2_1_5_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-03000002374-1</td><td headers="hd_h_ml302.tu2_1_5_1_1 hd_h_ml302.tu2_1_5_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">
|
||
<div class="graphic"><img src="/books/NBK143563/bin/ml302fu35.jpg" alt="Image ml302fu35.jpg" /></div></td><td headers="hd_h_ml302.tu2_1_5_1_1 hd_h_ml302.tu2_1_5_2_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">1560458</td><td headers="hd_h_ml302.tu2_1_5_1_1 hd_h_ml302.tu2_1_5_2_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/124384967" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">124384967</a></td><td headers="hd_h_ml302.tu2_1_5_1_1 hd_h_ml302.tu2_1_5_2_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_5_1_1 hd_h_ml302.tu2_1_5_2_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">TSRI</td><td headers="hd_h_ml302.tu2_1_5_1_1 hd_h_ml302.tu2_1_5_2_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">None</td><td headers="hd_h_ml302.tu2_1_5_1_2 hd_h_ml302.tu2_1_5_2_9 hd_h_ml302.tu2_1_5_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">12.5</td><td headers="hd_h_ml302.tu2_1_5_1_2 hd_h_ml302.tu2_1_5_2_9 hd_h_ml302.tu2_1_5_3_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">8X</td><td headers="hd_h_ml302.tu2_1_5_1_2 hd_h_ml302.tu2_1_5_2_10 hd_h_ml302.tu2_1_5_3_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_5_1_2 hd_h_ml302.tu2_1_5_2_10 hd_h_ml302.tu2_1_5_3_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td></tr><tr><td headers="hd_h_ml302.tu2_1_5_1_1 hd_h_ml302.tu2_1_5_2_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Analog 34</td><td headers="hd_h_ml302.tu2_1_5_1_1 hd_h_ml302.tu2_1_5_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-03000002431-1</td><td headers="hd_h_ml302.tu2_1_5_1_1 hd_h_ml302.tu2_1_5_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">
|
||
<div class="graphic"><img src="/books/NBK143563/bin/ml302fu36.jpg" alt="Image ml302fu36.jpg" /></div></td><td headers="hd_h_ml302.tu2_1_5_1_1 hd_h_ml302.tu2_1_5_2_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">53308606</td><td headers="hd_h_ml302.tu2_1_5_1_1 hd_h_ml302.tu2_1_5_2_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/124767335" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">124767335</a></td><td headers="hd_h_ml302.tu2_1_5_1_1 hd_h_ml302.tu2_1_5_2_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_5_1_1 hd_h_ml302.tu2_1_5_2_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">TSRI</td><td headers="hd_h_ml302.tu2_1_5_1_1 hd_h_ml302.tu2_1_5_2_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">None</td><td headers="hd_h_ml302.tu2_1_5_1_2 hd_h_ml302.tu2_1_5_2_9 hd_h_ml302.tu2_1_5_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">12.5</td><td headers="hd_h_ml302.tu2_1_5_1_2 hd_h_ml302.tu2_1_5_2_9 hd_h_ml302.tu2_1_5_3_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">8X</td><td headers="hd_h_ml302.tu2_1_5_1_2 hd_h_ml302.tu2_1_5_2_10 hd_h_ml302.tu2_1_5_3_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_5_1_2 hd_h_ml302.tu2_1_5_2_10 hd_h_ml302.tu2_1_5_3_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td></tr><tr><td headers="hd_h_ml302.tu2_1_5_1_1 hd_h_ml302.tu2_1_5_2_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Analog 35</td><td headers="hd_h_ml302.tu2_1_5_1_1 hd_h_ml302.tu2_1_5_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-03000002442-1</td><td headers="hd_h_ml302.tu2_1_5_1_1 hd_h_ml302.tu2_1_5_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">
|
||
<div class="graphic"><img src="/books/NBK143563/bin/ml302fu37.jpg" alt="Image ml302fu37.jpg" /></div></td><td headers="hd_h_ml302.tu2_1_5_1_1 hd_h_ml302.tu2_1_5_2_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">1280940</td><td headers="hd_h_ml302.tu2_1_5_1_1 hd_h_ml302.tu2_1_5_2_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/124767347" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">124767347</a></td><td headers="hd_h_ml302.tu2_1_5_1_1 hd_h_ml302.tu2_1_5_2_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_5_1_1 hd_h_ml302.tu2_1_5_2_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">TSRI</td><td headers="hd_h_ml302.tu2_1_5_1_1 hd_h_ml302.tu2_1_5_2_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">None</td><td headers="hd_h_ml302.tu2_1_5_1_2 hd_h_ml302.tu2_1_5_2_9 hd_h_ml302.tu2_1_5_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">100</td><td headers="hd_h_ml302.tu2_1_5_1_2 hd_h_ml302.tu2_1_5_2_9 hd_h_ml302.tu2_1_5_3_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_5_1_2 hd_h_ml302.tu2_1_5_2_10 hd_h_ml302.tu2_1_5_3_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_5_1_2 hd_h_ml302.tu2_1_5_2_10 hd_h_ml302.tu2_1_5_3_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td></tr><tr><td headers="hd_h_ml302.tu2_1_5_1_1 hd_h_ml302.tu2_1_5_2_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Analog 36</td><td headers="hd_h_ml302.tu2_1_5_1_1 hd_h_ml302.tu2_1_5_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-03000002458-1</td><td headers="hd_h_ml302.tu2_1_5_1_1 hd_h_ml302.tu2_1_5_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">
|
||
<div class="graphic"><img src="/books/NBK143563/bin/ml302fu38.jpg" alt="Image ml302fu38.jpg" /></div></td><td headers="hd_h_ml302.tu2_1_5_1_1 hd_h_ml302.tu2_1_5_2_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">1908865</td><td headers="hd_h_ml302.tu2_1_5_1_1 hd_h_ml302.tu2_1_5_2_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/125001876" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">125001876</a></td><td headers="hd_h_ml302.tu2_1_5_1_1 hd_h_ml302.tu2_1_5_2_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_5_1_1 hd_h_ml302.tu2_1_5_2_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Vitas-M Lab</td><td headers="hd_h_ml302.tu2_1_5_1_1 hd_h_ml302.tu2_1_5_2_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">STK861771</td><td headers="hd_h_ml302.tu2_1_5_1_2 hd_h_ml302.tu2_1_5_2_9 hd_h_ml302.tu2_1_5_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">12.5</td><td headers="hd_h_ml302.tu2_1_5_1_2 hd_h_ml302.tu2_1_5_2_9 hd_h_ml302.tu2_1_5_3_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">8X</td><td headers="hd_h_ml302.tu2_1_5_1_2 hd_h_ml302.tu2_1_5_2_10 hd_h_ml302.tu2_1_5_3_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_5_1_2 hd_h_ml302.tu2_1_5_2_10 hd_h_ml302.tu2_1_5_3_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td></tr><tr><td headers="hd_h_ml302.tu2_1_5_1_1 hd_h_ml302.tu2_1_5_2_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Analog 37</td><td headers="hd_h_ml302.tu2_1_5_1_1 hd_h_ml302.tu2_1_5_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-03000002397-1</td><td headers="hd_h_ml302.tu2_1_5_1_1 hd_h_ml302.tu2_1_5_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">
|
||
<div class="graphic"><img src="/books/NBK143563/bin/ml302fu39.jpg" alt="Image ml302fu39.jpg" /></div></td><td headers="hd_h_ml302.tu2_1_5_1_1 hd_h_ml302.tu2_1_5_2_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">53301874</td><td headers="hd_h_ml302.tu2_1_5_1_1 hd_h_ml302.tu2_1_5_2_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/124756532" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">124756532</a></td><td headers="hd_h_ml302.tu2_1_5_1_1 hd_h_ml302.tu2_1_5_2_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_5_1_1 hd_h_ml302.tu2_1_5_2_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">TSRI</td><td headers="hd_h_ml302.tu2_1_5_1_1 hd_h_ml302.tu2_1_5_2_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">None</td><td headers="hd_h_ml302.tu2_1_5_1_2 hd_h_ml302.tu2_1_5_2_9 hd_h_ml302.tu2_1_5_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">>100</td><td headers="hd_h_ml302.tu2_1_5_1_2 hd_h_ml302.tu2_1_5_2_9 hd_h_ml302.tu2_1_5_3_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_5_1_2 hd_h_ml302.tu2_1_5_2_10 hd_h_ml302.tu2_1_5_3_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_5_1_2 hd_h_ml302.tu2_1_5_2_10 hd_h_ml302.tu2_1_5_3_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td></tr><tr><td headers="hd_h_ml302.tu2_1_5_1_1 hd_h_ml302.tu2_1_5_2_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Analog 38</td><td headers="hd_h_ml302.tu2_1_5_1_1 hd_h_ml302.tu2_1_5_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-03000002454-1</td><td headers="hd_h_ml302.tu2_1_5_1_1 hd_h_ml302.tu2_1_5_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">
|
||
<div class="graphic"><img src="/books/NBK143563/bin/ml302fu40.jpg" alt="Image ml302fu40.jpg" /></div></td><td headers="hd_h_ml302.tu2_1_5_1_1 hd_h_ml302.tu2_1_5_2_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">1554607</td><td headers="hd_h_ml302.tu2_1_5_1_1 hd_h_ml302.tu2_1_5_2_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/125001872" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">125001872</a></td><td headers="hd_h_ml302.tu2_1_5_1_1 hd_h_ml302.tu2_1_5_2_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_5_1_1 hd_h_ml302.tu2_1_5_2_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Innovapharm Ltd.</td><td headers="hd_h_ml302.tu2_1_5_1_1 hd_h_ml302.tu2_1_5_2_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">STT-00172281</td><td headers="hd_h_ml302.tu2_1_5_1_2 hd_h_ml302.tu2_1_5_2_9 hd_h_ml302.tu2_1_5_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">>100</td><td headers="hd_h_ml302.tu2_1_5_1_2 hd_h_ml302.tu2_1_5_2_9 hd_h_ml302.tu2_1_5_3_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_5_1_2 hd_h_ml302.tu2_1_5_2_10 hd_h_ml302.tu2_1_5_3_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_5_1_2 hd_h_ml302.tu2_1_5_2_10 hd_h_ml302.tu2_1_5_3_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td></tr><tr><td headers="hd_h_ml302.tu2_1_5_1_1 hd_h_ml302.tu2_1_5_2_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Analog 39</td><td headers="hd_h_ml302.tu2_1_5_1_1 hd_h_ml302.tu2_1_5_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-03000002456-1</td><td headers="hd_h_ml302.tu2_1_5_1_1 hd_h_ml302.tu2_1_5_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">
|
||
<div class="graphic"><img src="/books/NBK143563/bin/ml302fu41.jpg" alt="Image ml302fu41.jpg" /></div></td><td headers="hd_h_ml302.tu2_1_5_1_1 hd_h_ml302.tu2_1_5_2_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">6226188</td><td headers="hd_h_ml302.tu2_1_5_1_1 hd_h_ml302.tu2_1_5_2_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/125001874" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">125001874</a></td><td headers="hd_h_ml302.tu2_1_5_1_1 hd_h_ml302.tu2_1_5_2_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_5_1_1 hd_h_ml302.tu2_1_5_2_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Vitas-M Lab</td><td headers="hd_h_ml302.tu2_1_5_1_1 hd_h_ml302.tu2_1_5_2_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">STK601034</td><td headers="hd_h_ml302.tu2_1_5_1_2 hd_h_ml302.tu2_1_5_2_9 hd_h_ml302.tu2_1_5_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">>100</td><td headers="hd_h_ml302.tu2_1_5_1_2 hd_h_ml302.tu2_1_5_2_9 hd_h_ml302.tu2_1_5_3_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_5_1_2 hd_h_ml302.tu2_1_5_2_10 hd_h_ml302.tu2_1_5_3_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_5_1_2 hd_h_ml302.tu2_1_5_2_10 hd_h_ml302.tu2_1_5_3_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td></tr></tbody></table><table><thead><tr><th id="hd_h_ml302.tu2_1_6_1_1" colspan="8" rowspan="1" style="text-align:center;vertical-align:middle;">Compound Information</th><th id="hd_h_ml302.tu2_1_6_1_2" colspan="9" rowspan="1" style="text-align:center;vertical-align:middle;">Bacterial Assays (Strain and MBL)</th></tr><tr><th headers="hd_h_ml302.tu2_1_6_1_1 hd_h_ml302.tu2_1_6_2_1" id="hd_h_ml302.tu2_1_6_2_1" rowspan="2" colspan="1" style="text-align:center;vertical-align:middle;">Compound</th><th headers="hd_h_ml302.tu2_1_6_1_1 hd_h_ml302.tu2_1_6_2_2" id="hd_h_ml302.tu2_1_6_2_2" rowspan="2" colspan="1" style="text-align:center;vertical-align:middle;">SR-Number</th><th headers="hd_h_ml302.tu2_1_6_1_1 hd_h_ml302.tu2_1_6_2_3" id="hd_h_ml302.tu2_1_6_2_3" rowspan="2" colspan="1" style="text-align:center;vertical-align:middle;">Structure</th><th headers="hd_h_ml302.tu2_1_6_1_1 hd_h_ml302.tu2_1_6_2_4" id="hd_h_ml302.tu2_1_6_2_4" rowspan="2" colspan="1" style="text-align:center;vertical-align:middle;">CID</th><th headers="hd_h_ml302.tu2_1_6_1_1 hd_h_ml302.tu2_1_6_2_5" id="hd_h_ml302.tu2_1_6_2_5" rowspan="2" colspan="1" style="text-align:center;vertical-align:middle;">SID</th><th headers="hd_h_ml302.tu2_1_6_1_1 hd_h_ml302.tu2_1_6_2_6" id="hd_h_ml302.tu2_1_6_2_6" rowspan="2" colspan="1" style="text-align:center;vertical-align:middle;">MLS</th><th headers="hd_h_ml302.tu2_1_6_1_1 hd_h_ml302.tu2_1_6_2_7" id="hd_h_ml302.tu2_1_6_2_7" rowspan="2" colspan="1" style="text-align:center;vertical-align:middle;">Vendor</th><th headers="hd_h_ml302.tu2_1_6_1_1 hd_h_ml302.tu2_1_6_2_8" id="hd_h_ml302.tu2_1_6_2_8" rowspan="2" colspan="1" style="text-align:center;vertical-align:middle;">Vendor Catalog ID</th><th headers="hd_h_ml302.tu2_1_6_1_2" id="hd_h_ml302.tu2_1_6_2_9" colspan="2" rowspan="1" style="text-align:center;vertical-align:middle;">BL21 (VIM-2)</th><th headers="hd_h_ml302.tu2_1_6_1_2" id="hd_h_ml302.tu2_1_6_2_10" colspan="2" rowspan="1" style="text-align:center;vertical-align:middle;">YMC07/B3323 (VIM-2)</th><th headers="hd_h_ml302.tu2_1_6_1_2" id="hd_h_ml302.tu2_1_6_2_11" colspan="2" rowspan="1" style="text-align:center;vertical-align:middle;">BAA-2146 (NDM-1)</th><th headers="hd_h_ml302.tu2_1_6_1_2" id="hd_h_ml302.tu2_1_6_2_12" colspan="2" rowspan="1" style="text-align:center;vertical-align:middle;">PA641 (VIM-2)</th><th headers="hd_h_ml302.tu2_1_6_1_2" id="hd_h_ml302.tu2_1_6_2_13" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">KN20</th></tr><tr><th headers="hd_h_ml302.tu2_1_6_1_2 hd_h_ml302.tu2_1_6_2_9" id="hd_h_ml302.tu2_1_6_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">MIC 4x (μM)</th><th headers="hd_h_ml302.tu2_1_6_1_2 hd_h_ml302.tu2_1_6_2_9" id="hd_h_ml302.tu2_1_6_3_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Imipenem Potentiation</th><th headers="hd_h_ml302.tu2_1_6_1_2 hd_h_ml302.tu2_1_6_2_10" id="hd_h_ml302.tu2_1_6_3_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">MIC 4x (μM)</th><th headers="hd_h_ml302.tu2_1_6_1_2 hd_h_ml302.tu2_1_6_2_10" id="hd_h_ml302.tu2_1_6_3_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Imipenem Potentiation</th><th headers="hd_h_ml302.tu2_1_6_1_2 hd_h_ml302.tu2_1_6_2_11" id="hd_h_ml302.tu2_1_6_3_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">MIC 4x (μM)</th><th headers="hd_h_ml302.tu2_1_6_1_2 hd_h_ml302.tu2_1_6_2_11" id="hd_h_ml302.tu2_1_6_3_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Imipenem Potentiation</th><th headers="hd_h_ml302.tu2_1_6_1_2 hd_h_ml302.tu2_1_6_2_12" id="hd_h_ml302.tu2_1_6_3_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">MIC 4x (μM)</th><th headers="hd_h_ml302.tu2_1_6_1_2 hd_h_ml302.tu2_1_6_2_12" id="hd_h_ml302.tu2_1_6_3_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Imipenem Potentiation</th><th headers="hd_h_ml302.tu2_1_6_1_2 hd_h_ml302.tu2_1_6_2_13" id="hd_h_ml302.tu2_1_6_3_9" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">MIC 4x (μM)</th></tr></thead><tbody><tr><td headers="hd_h_ml302.tu2_1_6_1_1 hd_h_ml302.tu2_1_6_2_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Analog 40</td><td headers="hd_h_ml302.tu2_1_6_1_1 hd_h_ml302.tu2_1_6_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-03000002462-1</td><td headers="hd_h_ml302.tu2_1_6_1_1 hd_h_ml302.tu2_1_6_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">
|
||
<div class="graphic"><img src="/books/NBK143563/bin/ml302fu42.jpg" alt="Image ml302fu42.jpg" /></div></td><td headers="hd_h_ml302.tu2_1_6_1_1 hd_h_ml302.tu2_1_6_2_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">5858470</td><td headers="hd_h_ml302.tu2_1_6_1_1 hd_h_ml302.tu2_1_6_2_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/125001881" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">125001881</a></td><td headers="hd_h_ml302.tu2_1_6_1_1 hd_h_ml302.tu2_1_6_2_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_6_1_1 hd_h_ml302.tu2_1_6_2_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Vitas-M Lab</td><td headers="hd_h_ml302.tu2_1_6_1_1 hd_h_ml302.tu2_1_6_2_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">STL035212</td><td headers="hd_h_ml302.tu2_1_6_1_2 hd_h_ml302.tu2_1_6_2_9 hd_h_ml302.tu2_1_6_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">100</td><td headers="hd_h_ml302.tu2_1_6_1_2 hd_h_ml302.tu2_1_6_2_9 hd_h_ml302.tu2_1_6_3_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_6_1_2 hd_h_ml302.tu2_1_6_2_10 hd_h_ml302.tu2_1_6_3_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_6_1_2 hd_h_ml302.tu2_1_6_2_10 hd_h_ml302.tu2_1_6_3_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_6_1_2 hd_h_ml302.tu2_1_6_2_11 hd_h_ml302.tu2_1_6_3_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_6_1_2 hd_h_ml302.tu2_1_6_2_11 hd_h_ml302.tu2_1_6_3_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_6_1_2 hd_h_ml302.tu2_1_6_2_12 hd_h_ml302.tu2_1_6_3_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_6_1_2 hd_h_ml302.tu2_1_6_2_12 hd_h_ml302.tu2_1_6_3_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_6_1_2 hd_h_ml302.tu2_1_6_2_13 hd_h_ml302.tu2_1_6_3_9" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td></tr><tr><td headers="hd_h_ml302.tu2_1_6_1_1 hd_h_ml302.tu2_1_6_2_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Analog 41</td><td headers="hd_h_ml302.tu2_1_6_1_1 hd_h_ml302.tu2_1_6_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-03000002446-1</td><td headers="hd_h_ml302.tu2_1_6_1_1 hd_h_ml302.tu2_1_6_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">
|
||
<div class="graphic"><img src="/books/NBK143563/bin/ml302fu43.jpg" alt="Image ml302fu43.jpg" /></div></td><td headers="hd_h_ml302.tu2_1_6_1_1 hd_h_ml302.tu2_1_6_2_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">53313356</td><td headers="hd_h_ml302.tu2_1_6_1_1 hd_h_ml302.tu2_1_6_2_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/124807341" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">124807341</a></td><td headers="hd_h_ml302.tu2_1_6_1_1 hd_h_ml302.tu2_1_6_2_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_6_1_1 hd_h_ml302.tu2_1_6_2_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">TSRI</td><td headers="hd_h_ml302.tu2_1_6_1_1 hd_h_ml302.tu2_1_6_2_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">None</td><td headers="hd_h_ml302.tu2_1_6_1_2 hd_h_ml302.tu2_1_6_2_9 hd_h_ml302.tu2_1_6_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">>100</td><td headers="hd_h_ml302.tu2_1_6_1_2 hd_h_ml302.tu2_1_6_2_9 hd_h_ml302.tu2_1_6_3_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_6_1_2 hd_h_ml302.tu2_1_6_2_10 hd_h_ml302.tu2_1_6_3_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_6_1_2 hd_h_ml302.tu2_1_6_2_10 hd_h_ml302.tu2_1_6_3_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_6_1_2 hd_h_ml302.tu2_1_6_2_11 hd_h_ml302.tu2_1_6_3_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_6_1_2 hd_h_ml302.tu2_1_6_2_11 hd_h_ml302.tu2_1_6_3_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_6_1_2 hd_h_ml302.tu2_1_6_2_12 hd_h_ml302.tu2_1_6_3_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_6_1_2 hd_h_ml302.tu2_1_6_2_12 hd_h_ml302.tu2_1_6_3_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_6_1_2 hd_h_ml302.tu2_1_6_2_13 hd_h_ml302.tu2_1_6_3_9" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td></tr><tr><td headers="hd_h_ml302.tu2_1_6_1_1 hd_h_ml302.tu2_1_6_2_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Analog 42</td><td headers="hd_h_ml302.tu2_1_6_1_1 hd_h_ml302.tu2_1_6_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-03000002451-1</td><td headers="hd_h_ml302.tu2_1_6_1_1 hd_h_ml302.tu2_1_6_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">
|
||
<div class="graphic"><img src="/books/NBK143563/bin/ml302fu44.jpg" alt="Image ml302fu44.jpg" /></div></td><td headers="hd_h_ml302.tu2_1_6_1_1 hd_h_ml302.tu2_1_6_2_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">53313350</td><td headers="hd_h_ml302.tu2_1_6_1_1 hd_h_ml302.tu2_1_6_2_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/124807346" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">124807346</a></td><td headers="hd_h_ml302.tu2_1_6_1_1 hd_h_ml302.tu2_1_6_2_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_6_1_1 hd_h_ml302.tu2_1_6_2_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">TSRI</td><td headers="hd_h_ml302.tu2_1_6_1_1 hd_h_ml302.tu2_1_6_2_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">None</td><td headers="hd_h_ml302.tu2_1_6_1_2 hd_h_ml302.tu2_1_6_2_9 hd_h_ml302.tu2_1_6_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">>100</td><td headers="hd_h_ml302.tu2_1_6_1_2 hd_h_ml302.tu2_1_6_2_9 hd_h_ml302.tu2_1_6_3_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_6_1_2 hd_h_ml302.tu2_1_6_2_10 hd_h_ml302.tu2_1_6_3_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_6_1_2 hd_h_ml302.tu2_1_6_2_10 hd_h_ml302.tu2_1_6_3_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_6_1_2 hd_h_ml302.tu2_1_6_2_11 hd_h_ml302.tu2_1_6_3_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_6_1_2 hd_h_ml302.tu2_1_6_2_11 hd_h_ml302.tu2_1_6_3_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_6_1_2 hd_h_ml302.tu2_1_6_2_12 hd_h_ml302.tu2_1_6_3_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_6_1_2 hd_h_ml302.tu2_1_6_2_12 hd_h_ml302.tu2_1_6_3_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_6_1_2 hd_h_ml302.tu2_1_6_2_13 hd_h_ml302.tu2_1_6_3_9" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td></tr><tr><td headers="hd_h_ml302.tu2_1_6_1_1 hd_h_ml302.tu2_1_6_2_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Analog 43</td><td headers="hd_h_ml302.tu2_1_6_1_1 hd_h_ml302.tu2_1_6_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-03000002452-1</td><td headers="hd_h_ml302.tu2_1_6_1_1 hd_h_ml302.tu2_1_6_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">
|
||
<div class="graphic"><img src="/books/NBK143563/bin/ml302fu45.jpg" alt="Image ml302fu45.jpg" /></div></td><td headers="hd_h_ml302.tu2_1_6_1_1 hd_h_ml302.tu2_1_6_2_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">53338906</td><td headers="hd_h_ml302.tu2_1_6_1_1 hd_h_ml302.tu2_1_6_2_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/125001870" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">125001870</a></td><td headers="hd_h_ml302.tu2_1_6_1_1 hd_h_ml302.tu2_1_6_2_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_6_1_1 hd_h_ml302.tu2_1_6_2_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">TSRI</td><td headers="hd_h_ml302.tu2_1_6_1_1 hd_h_ml302.tu2_1_6_2_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">None</td><td headers="hd_h_ml302.tu2_1_6_1_2 hd_h_ml302.tu2_1_6_2_9 hd_h_ml302.tu2_1_6_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">6.2</td><td headers="hd_h_ml302.tu2_1_6_1_2 hd_h_ml302.tu2_1_6_2_9 hd_h_ml302.tu2_1_6_3_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">8X</td><td headers="hd_h_ml302.tu2_1_6_1_2 hd_h_ml302.tu2_1_6_2_10 hd_h_ml302.tu2_1_6_3_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">12.5</td><td headers="hd_h_ml302.tu2_1_6_1_2 hd_h_ml302.tu2_1_6_2_10 hd_h_ml302.tu2_1_6_3_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">8X</td><td headers="hd_h_ml302.tu2_1_6_1_2 hd_h_ml302.tu2_1_6_2_11 hd_h_ml302.tu2_1_6_3_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">>100</td><td headers="hd_h_ml302.tu2_1_6_1_2 hd_h_ml302.tu2_1_6_2_11 hd_h_ml302.tu2_1_6_3_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_6_1_2 hd_h_ml302.tu2_1_6_2_12 hd_h_ml302.tu2_1_6_3_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">>100</td><td headers="hd_h_ml302.tu2_1_6_1_2 hd_h_ml302.tu2_1_6_2_12 hd_h_ml302.tu2_1_6_3_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_6_1_2 hd_h_ml302.tu2_1_6_2_13 hd_h_ml302.tu2_1_6_3_9" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">>100</td></tr><tr><td headers="hd_h_ml302.tu2_1_6_1_1 hd_h_ml302.tu2_1_6_2_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Analog 44</td><td headers="hd_h_ml302.tu2_1_6_1_1 hd_h_ml302.tu2_1_6_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-03000002449-1</td><td headers="hd_h_ml302.tu2_1_6_1_1 hd_h_ml302.tu2_1_6_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">
|
||
<div class="graphic"><img src="/books/NBK143563/bin/ml302fu46.jpg" alt="Image ml302fu46.jpg" /></div></td><td headers="hd_h_ml302.tu2_1_6_1_1 hd_h_ml302.tu2_1_6_2_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">53313352</td><td headers="hd_h_ml302.tu2_1_6_1_1 hd_h_ml302.tu2_1_6_2_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/124807344" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">124807344</a></td><td headers="hd_h_ml302.tu2_1_6_1_1 hd_h_ml302.tu2_1_6_2_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_6_1_1 hd_h_ml302.tu2_1_6_2_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">TSRI</td><td headers="hd_h_ml302.tu2_1_6_1_1 hd_h_ml302.tu2_1_6_2_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">None</td><td headers="hd_h_ml302.tu2_1_6_1_2 hd_h_ml302.tu2_1_6_2_9 hd_h_ml302.tu2_1_6_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">>100</td><td headers="hd_h_ml302.tu2_1_6_1_2 hd_h_ml302.tu2_1_6_2_9 hd_h_ml302.tu2_1_6_3_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_6_1_2 hd_h_ml302.tu2_1_6_2_10 hd_h_ml302.tu2_1_6_3_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_6_1_2 hd_h_ml302.tu2_1_6_2_10 hd_h_ml302.tu2_1_6_3_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_6_1_2 hd_h_ml302.tu2_1_6_2_11 hd_h_ml302.tu2_1_6_3_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_6_1_2 hd_h_ml302.tu2_1_6_2_11 hd_h_ml302.tu2_1_6_3_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_6_1_2 hd_h_ml302.tu2_1_6_2_12 hd_h_ml302.tu2_1_6_3_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_6_1_2 hd_h_ml302.tu2_1_6_2_12 hd_h_ml302.tu2_1_6_3_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_6_1_2 hd_h_ml302.tu2_1_6_2_13 hd_h_ml302.tu2_1_6_3_9" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td></tr><tr><td headers="hd_h_ml302.tu2_1_6_1_1 hd_h_ml302.tu2_1_6_2_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Analog 45</td><td headers="hd_h_ml302.tu2_1_6_1_1 hd_h_ml302.tu2_1_6_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-03000002450-1</td><td headers="hd_h_ml302.tu2_1_6_1_1 hd_h_ml302.tu2_1_6_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">
|
||
<div class="graphic"><img src="/books/NBK143563/bin/ml302fu47.jpg" alt="Image ml302fu47.jpg" /></div></td><td headers="hd_h_ml302.tu2_1_6_1_1 hd_h_ml302.tu2_1_6_2_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">53313351</td><td headers="hd_h_ml302.tu2_1_6_1_1 hd_h_ml302.tu2_1_6_2_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/124807345" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">124807345</a></td><td headers="hd_h_ml302.tu2_1_6_1_1 hd_h_ml302.tu2_1_6_2_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_6_1_1 hd_h_ml302.tu2_1_6_2_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">TSRI</td><td headers="hd_h_ml302.tu2_1_6_1_1 hd_h_ml302.tu2_1_6_2_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">None</td><td headers="hd_h_ml302.tu2_1_6_1_2 hd_h_ml302.tu2_1_6_2_9 hd_h_ml302.tu2_1_6_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">>100</td><td headers="hd_h_ml302.tu2_1_6_1_2 hd_h_ml302.tu2_1_6_2_9 hd_h_ml302.tu2_1_6_3_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_6_1_2 hd_h_ml302.tu2_1_6_2_10 hd_h_ml302.tu2_1_6_3_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_6_1_2 hd_h_ml302.tu2_1_6_2_10 hd_h_ml302.tu2_1_6_3_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_6_1_2 hd_h_ml302.tu2_1_6_2_11 hd_h_ml302.tu2_1_6_3_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_6_1_2 hd_h_ml302.tu2_1_6_2_11 hd_h_ml302.tu2_1_6_3_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_6_1_2 hd_h_ml302.tu2_1_6_2_12 hd_h_ml302.tu2_1_6_3_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_6_1_2 hd_h_ml302.tu2_1_6_2_12 hd_h_ml302.tu2_1_6_3_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_6_1_2 hd_h_ml302.tu2_1_6_2_13 hd_h_ml302.tu2_1_6_3_9" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td></tr><tr><td headers="hd_h_ml302.tu2_1_6_1_1 hd_h_ml302.tu2_1_6_2_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Analog 46</td><td headers="hd_h_ml302.tu2_1_6_1_1 hd_h_ml302.tu2_1_6_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-03000002480-1</td><td headers="hd_h_ml302.tu2_1_6_1_1 hd_h_ml302.tu2_1_6_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">
|
||
<div class="graphic"><img src="/books/NBK143563/bin/ml302fu48.jpg" alt="Image ml302fu48.jpg" /></div></td><td headers="hd_h_ml302.tu2_1_6_1_1 hd_h_ml302.tu2_1_6_2_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">53346521</td><td headers="hd_h_ml302.tu2_1_6_1_1 hd_h_ml302.tu2_1_6_2_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/125011825" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">125011825</a></td><td headers="hd_h_ml302.tu2_1_6_1_1 hd_h_ml302.tu2_1_6_2_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_6_1_1 hd_h_ml302.tu2_1_6_2_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">TSRI</td><td headers="hd_h_ml302.tu2_1_6_1_1 hd_h_ml302.tu2_1_6_2_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">None</td><td headers="hd_h_ml302.tu2_1_6_1_2 hd_h_ml302.tu2_1_6_2_9 hd_h_ml302.tu2_1_6_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">100</td><td headers="hd_h_ml302.tu2_1_6_1_2 hd_h_ml302.tu2_1_6_2_9 hd_h_ml302.tu2_1_6_3_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_6_1_2 hd_h_ml302.tu2_1_6_2_10 hd_h_ml302.tu2_1_6_3_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_6_1_2 hd_h_ml302.tu2_1_6_2_10 hd_h_ml302.tu2_1_6_3_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_6_1_2 hd_h_ml302.tu2_1_6_2_11 hd_h_ml302.tu2_1_6_3_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_6_1_2 hd_h_ml302.tu2_1_6_2_11 hd_h_ml302.tu2_1_6_3_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_6_1_2 hd_h_ml302.tu2_1_6_2_12 hd_h_ml302.tu2_1_6_3_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_6_1_2 hd_h_ml302.tu2_1_6_2_12 hd_h_ml302.tu2_1_6_3_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_6_1_2 hd_h_ml302.tu2_1_6_2_13 hd_h_ml302.tu2_1_6_3_9" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td></tr><tr><td headers="hd_h_ml302.tu2_1_6_1_1 hd_h_ml302.tu2_1_6_2_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Analog 47</td><td headers="hd_h_ml302.tu2_1_6_1_1 hd_h_ml302.tu2_1_6_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-03000002481-1</td><td headers="hd_h_ml302.tu2_1_6_1_1 hd_h_ml302.tu2_1_6_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">
|
||
<div class="graphic"><img src="/books/NBK143563/bin/ml302fu49.jpg" alt="Image ml302fu49.jpg" /></div></td><td headers="hd_h_ml302.tu2_1_6_1_1 hd_h_ml302.tu2_1_6_2_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">53346520</td><td headers="hd_h_ml302.tu2_1_6_1_1 hd_h_ml302.tu2_1_6_2_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/125011826" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">125011826</a></td><td headers="hd_h_ml302.tu2_1_6_1_1 hd_h_ml302.tu2_1_6_2_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_6_1_1 hd_h_ml302.tu2_1_6_2_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">TSRI</td><td headers="hd_h_ml302.tu2_1_6_1_1 hd_h_ml302.tu2_1_6_2_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">None</td><td headers="hd_h_ml302.tu2_1_6_1_2 hd_h_ml302.tu2_1_6_2_9 hd_h_ml302.tu2_1_6_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_6_1_2 hd_h_ml302.tu2_1_6_2_9 hd_h_ml302.tu2_1_6_3_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_6_1_2 hd_h_ml302.tu2_1_6_2_10 hd_h_ml302.tu2_1_6_3_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">1.563</td><td headers="hd_h_ml302.tu2_1_6_1_2 hd_h_ml302.tu2_1_6_2_10 hd_h_ml302.tu2_1_6_3_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">32X</td><td headers="hd_h_ml302.tu2_1_6_1_2 hd_h_ml302.tu2_1_6_2_11 hd_h_ml302.tu2_1_6_3_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_6_1_2 hd_h_ml302.tu2_1_6_2_11 hd_h_ml302.tu2_1_6_3_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_6_1_2 hd_h_ml302.tu2_1_6_2_12 hd_h_ml302.tu2_1_6_3_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_6_1_2 hd_h_ml302.tu2_1_6_2_12 hd_h_ml302.tu2_1_6_3_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_6_1_2 hd_h_ml302.tu2_1_6_2_13 hd_h_ml302.tu2_1_6_3_9" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td></tr><tr><td headers="hd_h_ml302.tu2_1_6_1_1 hd_h_ml302.tu2_1_6_2_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Analog 48</td><td headers="hd_h_ml302.tu2_1_6_1_1 hd_h_ml302.tu2_1_6_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-03000002384-1</td><td headers="hd_h_ml302.tu2_1_6_1_1 hd_h_ml302.tu2_1_6_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">
|
||
<div class="graphic"><img src="/books/NBK143563/bin/ml302fu50.jpg" alt="Image ml302fu50.jpg" /></div></td><td headers="hd_h_ml302.tu2_1_6_1_1 hd_h_ml302.tu2_1_6_2_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">53301887</td><td headers="hd_h_ml302.tu2_1_6_1_1 hd_h_ml302.tu2_1_6_2_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/124756518" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">124756518</a></td><td headers="hd_h_ml302.tu2_1_6_1_1 hd_h_ml302.tu2_1_6_2_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_6_1_1 hd_h_ml302.tu2_1_6_2_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">TSRI</td><td headers="hd_h_ml302.tu2_1_6_1_1 hd_h_ml302.tu2_1_6_2_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">None</td><td headers="hd_h_ml302.tu2_1_6_1_2 hd_h_ml302.tu2_1_6_2_9 hd_h_ml302.tu2_1_6_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">6.2</td><td headers="hd_h_ml302.tu2_1_6_1_2 hd_h_ml302.tu2_1_6_2_9 hd_h_ml302.tu2_1_6_3_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">8X</td><td headers="hd_h_ml302.tu2_1_6_1_2 hd_h_ml302.tu2_1_6_2_10 hd_h_ml302.tu2_1_6_3_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">3.125</td><td headers="hd_h_ml302.tu2_1_6_1_2 hd_h_ml302.tu2_1_6_2_10 hd_h_ml302.tu2_1_6_3_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">16X</td><td headers="hd_h_ml302.tu2_1_6_1_2 hd_h_ml302.tu2_1_6_2_11 hd_h_ml302.tu2_1_6_3_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_6_1_2 hd_h_ml302.tu2_1_6_2_11 hd_h_ml302.tu2_1_6_3_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_6_1_2 hd_h_ml302.tu2_1_6_2_12 hd_h_ml302.tu2_1_6_3_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">>100</td><td headers="hd_h_ml302.tu2_1_6_1_2 hd_h_ml302.tu2_1_6_2_12 hd_h_ml302.tu2_1_6_3_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_6_1_2 hd_h_ml302.tu2_1_6_2_13 hd_h_ml302.tu2_1_6_3_9" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">>100</td></tr><tr><td headers="hd_h_ml302.tu2_1_6_1_1 hd_h_ml302.tu2_1_6_2_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Analog 49</td><td headers="hd_h_ml302.tu2_1_6_1_1 hd_h_ml302.tu2_1_6_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-03000002453-1</td><td headers="hd_h_ml302.tu2_1_6_1_1 hd_h_ml302.tu2_1_6_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">
|
||
<div class="graphic"><img src="/books/NBK143563/bin/ml302fu51.jpg" alt="Image ml302fu51.jpg" /></div></td><td headers="hd_h_ml302.tu2_1_6_1_1 hd_h_ml302.tu2_1_6_2_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">53338912</td><td headers="hd_h_ml302.tu2_1_6_1_1 hd_h_ml302.tu2_1_6_2_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/125001871" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">125001871</a></td><td headers="hd_h_ml302.tu2_1_6_1_1 hd_h_ml302.tu2_1_6_2_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_6_1_1 hd_h_ml302.tu2_1_6_2_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">TSRI</td><td headers="hd_h_ml302.tu2_1_6_1_1 hd_h_ml302.tu2_1_6_2_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">None</td><td headers="hd_h_ml302.tu2_1_6_1_2 hd_h_ml302.tu2_1_6_2_9 hd_h_ml302.tu2_1_6_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">6.2</td><td headers="hd_h_ml302.tu2_1_6_1_2 hd_h_ml302.tu2_1_6_2_9 hd_h_ml302.tu2_1_6_3_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">8X</td><td headers="hd_h_ml302.tu2_1_6_1_2 hd_h_ml302.tu2_1_6_2_10 hd_h_ml302.tu2_1_6_3_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">3.125</td><td headers="hd_h_ml302.tu2_1_6_1_2 hd_h_ml302.tu2_1_6_2_10 hd_h_ml302.tu2_1_6_3_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">16X</td><td headers="hd_h_ml302.tu2_1_6_1_2 hd_h_ml302.tu2_1_6_2_11 hd_h_ml302.tu2_1_6_3_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">>100</td><td headers="hd_h_ml302.tu2_1_6_1_2 hd_h_ml302.tu2_1_6_2_11 hd_h_ml302.tu2_1_6_3_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_6_1_2 hd_h_ml302.tu2_1_6_2_12 hd_h_ml302.tu2_1_6_3_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">>100</td><td headers="hd_h_ml302.tu2_1_6_1_2 hd_h_ml302.tu2_1_6_2_12 hd_h_ml302.tu2_1_6_3_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_6_1_2 hd_h_ml302.tu2_1_6_2_13 hd_h_ml302.tu2_1_6_3_9" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">>100</td></tr><tr><td headers="hd_h_ml302.tu2_1_6_1_1 hd_h_ml302.tu2_1_6_2_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Analog 50</td><td headers="hd_h_ml302.tu2_1_6_1_1 hd_h_ml302.tu2_1_6_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-03000002482-1</td><td headers="hd_h_ml302.tu2_1_6_1_1 hd_h_ml302.tu2_1_6_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">
|
||
<div class="graphic"><img src="/books/NBK143563/bin/ml302fu52.jpg" alt="Image ml302fu52.jpg" /></div></td><td headers="hd_h_ml302.tu2_1_6_1_1 hd_h_ml302.tu2_1_6_2_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">53346529</td><td headers="hd_h_ml302.tu2_1_6_1_1 hd_h_ml302.tu2_1_6_2_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/125011827" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">125011827</a></td><td headers="hd_h_ml302.tu2_1_6_1_1 hd_h_ml302.tu2_1_6_2_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_6_1_1 hd_h_ml302.tu2_1_6_2_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">TSRI</td><td headers="hd_h_ml302.tu2_1_6_1_1 hd_h_ml302.tu2_1_6_2_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">None</td><td headers="hd_h_ml302.tu2_1_6_1_2 hd_h_ml302.tu2_1_6_2_9 hd_h_ml302.tu2_1_6_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">3.125</td><td headers="hd_h_ml302.tu2_1_6_1_2 hd_h_ml302.tu2_1_6_2_9 hd_h_ml302.tu2_1_6_3_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">8X</td><td headers="hd_h_ml302.tu2_1_6_1_2 hd_h_ml302.tu2_1_6_2_10 hd_h_ml302.tu2_1_6_3_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">3.125</td><td headers="hd_h_ml302.tu2_1_6_1_2 hd_h_ml302.tu2_1_6_2_10 hd_h_ml302.tu2_1_6_3_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">16X</td><td headers="hd_h_ml302.tu2_1_6_1_2 hd_h_ml302.tu2_1_6_2_11 hd_h_ml302.tu2_1_6_3_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">>50</td><td headers="hd_h_ml302.tu2_1_6_1_2 hd_h_ml302.tu2_1_6_2_11 hd_h_ml302.tu2_1_6_3_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_6_1_2 hd_h_ml302.tu2_1_6_2_12 hd_h_ml302.tu2_1_6_3_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">>50</td><td headers="hd_h_ml302.tu2_1_6_1_2 hd_h_ml302.tu2_1_6_2_12 hd_h_ml302.tu2_1_6_3_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">2X</td><td headers="hd_h_ml302.tu2_1_6_1_2 hd_h_ml302.tu2_1_6_2_13 hd_h_ml302.tu2_1_6_3_9" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">>50</td></tr><tr><td headers="hd_h_ml302.tu2_1_6_1_1 hd_h_ml302.tu2_1_6_2_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Analog 51</td><td headers="hd_h_ml302.tu2_1_6_1_1 hd_h_ml302.tu2_1_6_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-03000002588-1</td><td headers="hd_h_ml302.tu2_1_6_1_1 hd_h_ml302.tu2_1_6_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">
|
||
<div class="graphic"><img src="/books/NBK143563/bin/ml302fu53.jpg" alt="Image ml302fu53.jpg" /></div></td><td headers="hd_h_ml302.tu2_1_6_1_1 hd_h_ml302.tu2_1_6_2_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">53384710</td><td headers="hd_h_ml302.tu2_1_6_1_1 hd_h_ml302.tu2_1_6_2_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/125311272" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">125311272</a></td><td headers="hd_h_ml302.tu2_1_6_1_1 hd_h_ml302.tu2_1_6_2_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_6_1_1 hd_h_ml302.tu2_1_6_2_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">TSRI</td><td headers="hd_h_ml302.tu2_1_6_1_1 hd_h_ml302.tu2_1_6_2_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">None</td><td headers="hd_h_ml302.tu2_1_6_1_2 hd_h_ml302.tu2_1_6_2_9 hd_h_ml302.tu2_1_6_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">12.5</td><td headers="hd_h_ml302.tu2_1_6_1_2 hd_h_ml302.tu2_1_6_2_9 hd_h_ml302.tu2_1_6_3_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">16X</td><td headers="hd_h_ml302.tu2_1_6_1_2 hd_h_ml302.tu2_1_6_2_10 hd_h_ml302.tu2_1_6_3_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">6.25</td><td headers="hd_h_ml302.tu2_1_6_1_2 hd_h_ml302.tu2_1_6_2_10 hd_h_ml302.tu2_1_6_3_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">32X</td><td headers="hd_h_ml302.tu2_1_6_1_2 hd_h_ml302.tu2_1_6_2_11 hd_h_ml302.tu2_1_6_3_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">>50</td><td headers="hd_h_ml302.tu2_1_6_1_2 hd_h_ml302.tu2_1_6_2_11 hd_h_ml302.tu2_1_6_3_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_6_1_2 hd_h_ml302.tu2_1_6_2_12 hd_h_ml302.tu2_1_6_3_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_6_1_2 hd_h_ml302.tu2_1_6_2_12 hd_h_ml302.tu2_1_6_3_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_6_1_2 hd_h_ml302.tu2_1_6_2_13 hd_h_ml302.tu2_1_6_3_9" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">>50</td></tr><tr><td headers="hd_h_ml302.tu2_1_6_1_1 hd_h_ml302.tu2_1_6_2_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Analog 52</td><td headers="hd_h_ml302.tu2_1_6_1_1 hd_h_ml302.tu2_1_6_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-03000002589-1</td><td headers="hd_h_ml302.tu2_1_6_1_1 hd_h_ml302.tu2_1_6_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">
|
||
<div class="graphic"><img src="/books/NBK143563/bin/ml302fu54.jpg" alt="Image ml302fu54.jpg" /></div></td><td headers="hd_h_ml302.tu2_1_6_1_1 hd_h_ml302.tu2_1_6_2_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">53384681</td><td headers="hd_h_ml302.tu2_1_6_1_1 hd_h_ml302.tu2_1_6_2_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/125311273" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">125311273</a></td><td headers="hd_h_ml302.tu2_1_6_1_1 hd_h_ml302.tu2_1_6_2_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_6_1_1 hd_h_ml302.tu2_1_6_2_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">TSRI</td><td headers="hd_h_ml302.tu2_1_6_1_1 hd_h_ml302.tu2_1_6_2_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">None</td><td headers="hd_h_ml302.tu2_1_6_1_2 hd_h_ml302.tu2_1_6_2_9 hd_h_ml302.tu2_1_6_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_6_1_2 hd_h_ml302.tu2_1_6_2_9 hd_h_ml302.tu2_1_6_3_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_6_1_2 hd_h_ml302.tu2_1_6_2_10 hd_h_ml302.tu2_1_6_3_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">3.125</td><td headers="hd_h_ml302.tu2_1_6_1_2 hd_h_ml302.tu2_1_6_2_10 hd_h_ml302.tu2_1_6_3_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_6_1_2 hd_h_ml302.tu2_1_6_2_11 hd_h_ml302.tu2_1_6_3_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">>50</td><td headers="hd_h_ml302.tu2_1_6_1_2 hd_h_ml302.tu2_1_6_2_11 hd_h_ml302.tu2_1_6_3_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_6_1_2 hd_h_ml302.tu2_1_6_2_12 hd_h_ml302.tu2_1_6_3_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">>50</td><td headers="hd_h_ml302.tu2_1_6_1_2 hd_h_ml302.tu2_1_6_2_12 hd_h_ml302.tu2_1_6_3_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_6_1_2 hd_h_ml302.tu2_1_6_2_13 hd_h_ml302.tu2_1_6_3_9" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">>50</td></tr><tr><td headers="hd_h_ml302.tu2_1_6_1_1 hd_h_ml302.tu2_1_6_2_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Analog 53</td><td headers="hd_h_ml302.tu2_1_6_1_1 hd_h_ml302.tu2_1_6_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-03000002590-1</td><td headers="hd_h_ml302.tu2_1_6_1_1 hd_h_ml302.tu2_1_6_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">
|
||
<div class="graphic"><img src="/books/NBK143563/bin/ml302fu55.jpg" alt="Image ml302fu55.jpg" /></div></td><td headers="hd_h_ml302.tu2_1_6_1_1 hd_h_ml302.tu2_1_6_2_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">53384726</td><td headers="hd_h_ml302.tu2_1_6_1_1 hd_h_ml302.tu2_1_6_2_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/125311274" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">125311274</a></td><td headers="hd_h_ml302.tu2_1_6_1_1 hd_h_ml302.tu2_1_6_2_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_6_1_1 hd_h_ml302.tu2_1_6_2_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">TSRI</td><td headers="hd_h_ml302.tu2_1_6_1_1 hd_h_ml302.tu2_1_6_2_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">None</td><td headers="hd_h_ml302.tu2_1_6_1_2 hd_h_ml302.tu2_1_6_2_9 hd_h_ml302.tu2_1_6_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_6_1_2 hd_h_ml302.tu2_1_6_2_9 hd_h_ml302.tu2_1_6_3_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_6_1_2 hd_h_ml302.tu2_1_6_2_10 hd_h_ml302.tu2_1_6_3_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">6.25</td><td headers="hd_h_ml302.tu2_1_6_1_2 hd_h_ml302.tu2_1_6_2_10 hd_h_ml302.tu2_1_6_3_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">32X</td><td headers="hd_h_ml302.tu2_1_6_1_2 hd_h_ml302.tu2_1_6_2_11 hd_h_ml302.tu2_1_6_3_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">>50</td><td headers="hd_h_ml302.tu2_1_6_1_2 hd_h_ml302.tu2_1_6_2_11 hd_h_ml302.tu2_1_6_3_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_6_1_2 hd_h_ml302.tu2_1_6_2_12 hd_h_ml302.tu2_1_6_3_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">>50</td><td headers="hd_h_ml302.tu2_1_6_1_2 hd_h_ml302.tu2_1_6_2_12 hd_h_ml302.tu2_1_6_3_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">2X</td><td headers="hd_h_ml302.tu2_1_6_1_2 hd_h_ml302.tu2_1_6_2_13 hd_h_ml302.tu2_1_6_3_9" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">>50</td></tr><tr><td headers="hd_h_ml302.tu2_1_6_1_1 hd_h_ml302.tu2_1_6_2_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Analog 54</td><td headers="hd_h_ml302.tu2_1_6_1_1 hd_h_ml302.tu2_1_6_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-03000002591-1</td><td headers="hd_h_ml302.tu2_1_6_1_1 hd_h_ml302.tu2_1_6_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">
|
||
<div class="graphic"><img src="/books/NBK143563/bin/ml302fu56.jpg" alt="Image ml302fu56.jpg" /></div></td><td headers="hd_h_ml302.tu2_1_6_1_1 hd_h_ml302.tu2_1_6_2_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">53384676</td><td headers="hd_h_ml302.tu2_1_6_1_1 hd_h_ml302.tu2_1_6_2_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/125311275" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">125311275</a></td><td headers="hd_h_ml302.tu2_1_6_1_1 hd_h_ml302.tu2_1_6_2_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_6_1_1 hd_h_ml302.tu2_1_6_2_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">TSRI</td><td headers="hd_h_ml302.tu2_1_6_1_1 hd_h_ml302.tu2_1_6_2_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">None</td><td headers="hd_h_ml302.tu2_1_6_1_2 hd_h_ml302.tu2_1_6_2_9 hd_h_ml302.tu2_1_6_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_6_1_2 hd_h_ml302.tu2_1_6_2_9 hd_h_ml302.tu2_1_6_3_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_6_1_2 hd_h_ml302.tu2_1_6_2_10 hd_h_ml302.tu2_1_6_3_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">3.125</td><td headers="hd_h_ml302.tu2_1_6_1_2 hd_h_ml302.tu2_1_6_2_10 hd_h_ml302.tu2_1_6_3_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">16X</td><td headers="hd_h_ml302.tu2_1_6_1_2 hd_h_ml302.tu2_1_6_2_11 hd_h_ml302.tu2_1_6_3_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">>50</td><td headers="hd_h_ml302.tu2_1_6_1_2 hd_h_ml302.tu2_1_6_2_11 hd_h_ml302.tu2_1_6_3_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_6_1_2 hd_h_ml302.tu2_1_6_2_12 hd_h_ml302.tu2_1_6_3_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">>50</td><td headers="hd_h_ml302.tu2_1_6_1_2 hd_h_ml302.tu2_1_6_2_12 hd_h_ml302.tu2_1_6_3_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_6_1_2 hd_h_ml302.tu2_1_6_2_13 hd_h_ml302.tu2_1_6_3_9" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">>50</td></tr><tr><td headers="hd_h_ml302.tu2_1_6_1_1 hd_h_ml302.tu2_1_6_2_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Analog 55</td><td headers="hd_h_ml302.tu2_1_6_1_1 hd_h_ml302.tu2_1_6_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-03000002592-1</td><td headers="hd_h_ml302.tu2_1_6_1_1 hd_h_ml302.tu2_1_6_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">
|
||
<div class="graphic"><img src="/books/NBK143563/bin/ml302fu57.jpg" alt="Image ml302fu57.jpg" /></div></td><td headers="hd_h_ml302.tu2_1_6_1_1 hd_h_ml302.tu2_1_6_2_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">53384686</td><td headers="hd_h_ml302.tu2_1_6_1_1 hd_h_ml302.tu2_1_6_2_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/125311276" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">125311276</a></td><td headers="hd_h_ml302.tu2_1_6_1_1 hd_h_ml302.tu2_1_6_2_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_6_1_1 hd_h_ml302.tu2_1_6_2_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">TSRI</td><td headers="hd_h_ml302.tu2_1_6_1_1 hd_h_ml302.tu2_1_6_2_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">None</td><td headers="hd_h_ml302.tu2_1_6_1_2 hd_h_ml302.tu2_1_6_2_9 hd_h_ml302.tu2_1_6_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_6_1_2 hd_h_ml302.tu2_1_6_2_9 hd_h_ml302.tu2_1_6_3_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_6_1_2 hd_h_ml302.tu2_1_6_2_10 hd_h_ml302.tu2_1_6_3_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">25</td><td headers="hd_h_ml302.tu2_1_6_1_2 hd_h_ml302.tu2_1_6_2_10 hd_h_ml302.tu2_1_6_3_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_6_1_2 hd_h_ml302.tu2_1_6_2_11 hd_h_ml302.tu2_1_6_3_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_6_1_2 hd_h_ml302.tu2_1_6_2_11 hd_h_ml302.tu2_1_6_3_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_6_1_2 hd_h_ml302.tu2_1_6_2_12 hd_h_ml302.tu2_1_6_3_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_6_1_2 hd_h_ml302.tu2_1_6_2_12 hd_h_ml302.tu2_1_6_3_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_6_1_2 hd_h_ml302.tu2_1_6_2_13 hd_h_ml302.tu2_1_6_3_9" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td></tr><tr><td headers="hd_h_ml302.tu2_1_6_1_1 hd_h_ml302.tu2_1_6_2_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Analog 56</td><td headers="hd_h_ml302.tu2_1_6_1_1 hd_h_ml302.tu2_1_6_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-03000002593-1</td><td headers="hd_h_ml302.tu2_1_6_1_1 hd_h_ml302.tu2_1_6_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">
|
||
<div class="graphic"><img src="/books/NBK143563/bin/ml302fu58.jpg" alt="Image ml302fu58.jpg" /></div></td><td headers="hd_h_ml302.tu2_1_6_1_1 hd_h_ml302.tu2_1_6_2_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">53384728</td><td headers="hd_h_ml302.tu2_1_6_1_1 hd_h_ml302.tu2_1_6_2_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/125311277" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">125311277</a></td><td headers="hd_h_ml302.tu2_1_6_1_1 hd_h_ml302.tu2_1_6_2_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_6_1_1 hd_h_ml302.tu2_1_6_2_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">TSRI</td><td headers="hd_h_ml302.tu2_1_6_1_1 hd_h_ml302.tu2_1_6_2_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">None</td><td headers="hd_h_ml302.tu2_1_6_1_2 hd_h_ml302.tu2_1_6_2_9 hd_h_ml302.tu2_1_6_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_6_1_2 hd_h_ml302.tu2_1_6_2_9 hd_h_ml302.tu2_1_6_3_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_6_1_2 hd_h_ml302.tu2_1_6_2_10 hd_h_ml302.tu2_1_6_3_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">>50</td><td headers="hd_h_ml302.tu2_1_6_1_2 hd_h_ml302.tu2_1_6_2_10 hd_h_ml302.tu2_1_6_3_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">2X</td><td headers="hd_h_ml302.tu2_1_6_1_2 hd_h_ml302.tu2_1_6_2_11 hd_h_ml302.tu2_1_6_3_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_6_1_2 hd_h_ml302.tu2_1_6_2_11 hd_h_ml302.tu2_1_6_3_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_6_1_2 hd_h_ml302.tu2_1_6_2_12 hd_h_ml302.tu2_1_6_3_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_6_1_2 hd_h_ml302.tu2_1_6_2_12 hd_h_ml302.tu2_1_6_3_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_6_1_2 hd_h_ml302.tu2_1_6_2_13 hd_h_ml302.tu2_1_6_3_9" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td></tr><tr><td headers="hd_h_ml302.tu2_1_6_1_1 hd_h_ml302.tu2_1_6_2_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Analog 57</td><td headers="hd_h_ml302.tu2_1_6_1_1 hd_h_ml302.tu2_1_6_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-03000002737-1</td><td headers="hd_h_ml302.tu2_1_6_1_1 hd_h_ml302.tu2_1_6_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">
|
||
<div class="graphic"><img src="/books/NBK143563/bin/ml302fu59.jpg" alt="Image ml302fu59.jpg" /></div></td><td headers="hd_h_ml302.tu2_1_6_1_1 hd_h_ml302.tu2_1_6_2_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">54669692</td><td headers="hd_h_ml302.tu2_1_6_1_1 hd_h_ml302.tu2_1_6_2_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/131465571" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">131465571</a></td><td headers="hd_h_ml302.tu2_1_6_1_1 hd_h_ml302.tu2_1_6_2_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_6_1_1 hd_h_ml302.tu2_1_6_2_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">TSRI</td><td headers="hd_h_ml302.tu2_1_6_1_1 hd_h_ml302.tu2_1_6_2_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">None</td><td headers="hd_h_ml302.tu2_1_6_1_2 hd_h_ml302.tu2_1_6_2_9 hd_h_ml302.tu2_1_6_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_6_1_2 hd_h_ml302.tu2_1_6_2_9 hd_h_ml302.tu2_1_6_3_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_6_1_2 hd_h_ml302.tu2_1_6_2_10 hd_h_ml302.tu2_1_6_3_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">25</td><td headers="hd_h_ml302.tu2_1_6_1_2 hd_h_ml302.tu2_1_6_2_10 hd_h_ml302.tu2_1_6_3_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">8X</td><td headers="hd_h_ml302.tu2_1_6_1_2 hd_h_ml302.tu2_1_6_2_11 hd_h_ml302.tu2_1_6_3_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_6_1_2 hd_h_ml302.tu2_1_6_2_11 hd_h_ml302.tu2_1_6_3_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_6_1_2 hd_h_ml302.tu2_1_6_2_12 hd_h_ml302.tu2_1_6_3_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_6_1_2 hd_h_ml302.tu2_1_6_2_12 hd_h_ml302.tu2_1_6_3_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_6_1_2 hd_h_ml302.tu2_1_6_2_13 hd_h_ml302.tu2_1_6_3_9" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td></tr><tr><td headers="hd_h_ml302.tu2_1_6_1_1 hd_h_ml302.tu2_1_6_2_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Analog 58</td><td headers="hd_h_ml302.tu2_1_6_1_1 hd_h_ml302.tu2_1_6_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-03000002373-1</td><td headers="hd_h_ml302.tu2_1_6_1_1 hd_h_ml302.tu2_1_6_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">
|
||
<div class="graphic"><img src="/books/NBK143563/bin/ml302fu60.jpg" alt="Image ml302fu60.jpg" /></div></td><td headers="hd_h_ml302.tu2_1_6_1_1 hd_h_ml302.tu2_1_6_2_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">1201205</td><td headers="hd_h_ml302.tu2_1_6_1_1 hd_h_ml302.tu2_1_6_2_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/124384966" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">124384966</a></td><td headers="hd_h_ml302.tu2_1_6_1_1 hd_h_ml302.tu2_1_6_2_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_6_1_1 hd_h_ml302.tu2_1_6_2_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">TSRI</td><td headers="hd_h_ml302.tu2_1_6_1_1 hd_h_ml302.tu2_1_6_2_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">None</td><td headers="hd_h_ml302.tu2_1_6_1_2 hd_h_ml302.tu2_1_6_2_9 hd_h_ml302.tu2_1_6_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">3.125</td><td headers="hd_h_ml302.tu2_1_6_1_2 hd_h_ml302.tu2_1_6_2_9 hd_h_ml302.tu2_1_6_3_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">8X</td><td headers="hd_h_ml302.tu2_1_6_1_2 hd_h_ml302.tu2_1_6_2_10 hd_h_ml302.tu2_1_6_3_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">12.5</td><td headers="hd_h_ml302.tu2_1_6_1_2 hd_h_ml302.tu2_1_6_2_10 hd_h_ml302.tu2_1_6_3_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">16X</td><td headers="hd_h_ml302.tu2_1_6_1_2 hd_h_ml302.tu2_1_6_2_11 hd_h_ml302.tu2_1_6_3_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">>100</td><td headers="hd_h_ml302.tu2_1_6_1_2 hd_h_ml302.tu2_1_6_2_11 hd_h_ml302.tu2_1_6_3_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_6_1_2 hd_h_ml302.tu2_1_6_2_12 hd_h_ml302.tu2_1_6_3_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">>100</td><td headers="hd_h_ml302.tu2_1_6_1_2 hd_h_ml302.tu2_1_6_2_12 hd_h_ml302.tu2_1_6_3_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_6_1_2 hd_h_ml302.tu2_1_6_2_13 hd_h_ml302.tu2_1_6_3_9" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">>100</td></tr><tr><td headers="hd_h_ml302.tu2_1_6_1_1 hd_h_ml302.tu2_1_6_2_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Analog 59</td><td headers="hd_h_ml302.tu2_1_6_1_1 hd_h_ml302.tu2_1_6_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-03000002519-1</td><td headers="hd_h_ml302.tu2_1_6_1_1 hd_h_ml302.tu2_1_6_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">
|
||
<div class="graphic"><img src="/books/NBK143563/bin/ml302fu61.jpg" alt="Image ml302fu61.jpg" /></div></td><td headers="hd_h_ml302.tu2_1_6_1_1 hd_h_ml302.tu2_1_6_2_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">1205102</td><td headers="hd_h_ml302.tu2_1_6_1_1 hd_h_ml302.tu2_1_6_2_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/125258648" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">125258648</a></td><td headers="hd_h_ml302.tu2_1_6_1_1 hd_h_ml302.tu2_1_6_2_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_6_1_1 hd_h_ml302.tu2_1_6_2_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">TSRI</td><td headers="hd_h_ml302.tu2_1_6_1_1 hd_h_ml302.tu2_1_6_2_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">None</td><td headers="hd_h_ml302.tu2_1_6_1_2 hd_h_ml302.tu2_1_6_2_9 hd_h_ml302.tu2_1_6_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_6_1_2 hd_h_ml302.tu2_1_6_2_9 hd_h_ml302.tu2_1_6_3_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_6_1_2 hd_h_ml302.tu2_1_6_2_10 hd_h_ml302.tu2_1_6_3_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">>50</td><td headers="hd_h_ml302.tu2_1_6_1_2 hd_h_ml302.tu2_1_6_2_10 hd_h_ml302.tu2_1_6_3_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">2X</td><td headers="hd_h_ml302.tu2_1_6_1_2 hd_h_ml302.tu2_1_6_2_11 hd_h_ml302.tu2_1_6_3_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_6_1_2 hd_h_ml302.tu2_1_6_2_11 hd_h_ml302.tu2_1_6_3_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_6_1_2 hd_h_ml302.tu2_1_6_2_12 hd_h_ml302.tu2_1_6_3_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_6_1_2 hd_h_ml302.tu2_1_6_2_12 hd_h_ml302.tu2_1_6_3_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_6_1_2 hd_h_ml302.tu2_1_6_2_13 hd_h_ml302.tu2_1_6_3_9" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td></tr></tbody></table><table><thead><tr><th id="hd_h_ml302.tu2_1_7_1_1" colspan="8" rowspan="1" style="text-align:center;vertical-align:middle;">Compound Information</th><th id="hd_h_ml302.tu2_1_7_1_2" colspan="4" rowspan="1" style="text-align:center;vertical-align:middle;">Bacterial Assays (Strain and MBL)</th></tr><tr><th headers="hd_h_ml302.tu2_1_7_1_1 hd_h_ml302.tu2_1_7_2_1" id="hd_h_ml302.tu2_1_7_2_1" rowspan="2" colspan="1" style="text-align:center;vertical-align:middle;">Compound</th><th headers="hd_h_ml302.tu2_1_7_1_1 hd_h_ml302.tu2_1_7_2_2" id="hd_h_ml302.tu2_1_7_2_2" rowspan="2" colspan="1" style="text-align:center;vertical-align:middle;">SR-Number</th><th headers="hd_h_ml302.tu2_1_7_1_1 hd_h_ml302.tu2_1_7_2_3" id="hd_h_ml302.tu2_1_7_2_3" rowspan="2" colspan="1" style="text-align:center;vertical-align:middle;">Structure</th><th headers="hd_h_ml302.tu2_1_7_1_1 hd_h_ml302.tu2_1_7_2_4" id="hd_h_ml302.tu2_1_7_2_4" rowspan="2" colspan="1" style="text-align:center;vertical-align:middle;">CID</th><th headers="hd_h_ml302.tu2_1_7_1_1 hd_h_ml302.tu2_1_7_2_5" id="hd_h_ml302.tu2_1_7_2_5" rowspan="2" colspan="1" style="text-align:center;vertical-align:middle;">SID</th><th headers="hd_h_ml302.tu2_1_7_1_1 hd_h_ml302.tu2_1_7_2_6" id="hd_h_ml302.tu2_1_7_2_6" rowspan="2" colspan="1" style="text-align:center;vertical-align:middle;">MLS</th><th headers="hd_h_ml302.tu2_1_7_1_1 hd_h_ml302.tu2_1_7_2_7" id="hd_h_ml302.tu2_1_7_2_7" rowspan="2" colspan="1" style="text-align:center;vertical-align:middle;">Vendor</th><th headers="hd_h_ml302.tu2_1_7_1_1 hd_h_ml302.tu2_1_7_2_8" id="hd_h_ml302.tu2_1_7_2_8" rowspan="2" colspan="1" style="text-align:center;vertical-align:middle;">Vendor Catalog ID</th><th headers="hd_h_ml302.tu2_1_7_1_2" id="hd_h_ml302.tu2_1_7_2_9" colspan="2" rowspan="1" style="text-align:center;vertical-align:middle;">BL21 (VIM-2)</th><th headers="hd_h_ml302.tu2_1_7_1_2" id="hd_h_ml302.tu2_1_7_2_10" colspan="2" rowspan="1" style="text-align:center;vertical-align:middle;">YMC07/B3323 (VIM-2)</th></tr><tr><th headers="hd_h_ml302.tu2_1_7_1_2 hd_h_ml302.tu2_1_7_2_9" id="hd_h_ml302.tu2_1_7_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">MIC 4x (μM)</th><th headers="hd_h_ml302.tu2_1_7_1_2 hd_h_ml302.tu2_1_7_2_9" id="hd_h_ml302.tu2_1_7_3_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Imipenem Potentiation</th><th headers="hd_h_ml302.tu2_1_7_1_2 hd_h_ml302.tu2_1_7_2_10" id="hd_h_ml302.tu2_1_7_3_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">MIC 4x (μM)</th><th headers="hd_h_ml302.tu2_1_7_1_2 hd_h_ml302.tu2_1_7_2_10" id="hd_h_ml302.tu2_1_7_3_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Imipenem Potentiation</th></tr></thead><tbody><tr><td headers="hd_h_ml302.tu2_1_7_1_1 hd_h_ml302.tu2_1_7_2_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Analog 60</td><td headers="hd_h_ml302.tu2_1_7_1_1 hd_h_ml302.tu2_1_7_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-03000002520-1</td><td headers="hd_h_ml302.tu2_1_7_1_1 hd_h_ml302.tu2_1_7_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">
|
||
<div class="graphic"><img src="/books/NBK143563/bin/ml302fu62.jpg" alt="Image ml302fu62.jpg" /></div></td><td headers="hd_h_ml302.tu2_1_7_1_1 hd_h_ml302.tu2_1_7_2_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">1201114</td><td headers="hd_h_ml302.tu2_1_7_1_1 hd_h_ml302.tu2_1_7_2_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/125258649" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">125258649</a></td><td headers="hd_h_ml302.tu2_1_7_1_1 hd_h_ml302.tu2_1_7_2_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_7_1_1 hd_h_ml302.tu2_1_7_2_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">TSRI</td><td headers="hd_h_ml302.tu2_1_7_1_1 hd_h_ml302.tu2_1_7_2_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">None</td><td headers="hd_h_ml302.tu2_1_7_1_2 hd_h_ml302.tu2_1_7_2_9 hd_h_ml302.tu2_1_7_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_7_1_2 hd_h_ml302.tu2_1_7_2_9 hd_h_ml302.tu2_1_7_3_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_7_1_2 hd_h_ml302.tu2_1_7_2_10 hd_h_ml302.tu2_1_7_3_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">>50</td><td headers="hd_h_ml302.tu2_1_7_1_2 hd_h_ml302.tu2_1_7_2_10 hd_h_ml302.tu2_1_7_3_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">2X</td></tr><tr><td headers="hd_h_ml302.tu2_1_7_1_1 hd_h_ml302.tu2_1_7_2_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Analog 61</td><td headers="hd_h_ml302.tu2_1_7_1_1 hd_h_ml302.tu2_1_7_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-03000002521-1</td><td headers="hd_h_ml302.tu2_1_7_1_1 hd_h_ml302.tu2_1_7_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">
|
||
<div class="graphic"><img src="/books/NBK143563/bin/ml302fu63.jpg" alt="Image ml302fu63.jpg" /></div></td><td headers="hd_h_ml302.tu2_1_7_1_1 hd_h_ml302.tu2_1_7_2_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">1622325</td><td headers="hd_h_ml302.tu2_1_7_1_1 hd_h_ml302.tu2_1_7_2_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/125258651" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">125258651</a></td><td headers="hd_h_ml302.tu2_1_7_1_1 hd_h_ml302.tu2_1_7_2_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_7_1_1 hd_h_ml302.tu2_1_7_2_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">TSRI</td><td headers="hd_h_ml302.tu2_1_7_1_1 hd_h_ml302.tu2_1_7_2_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">None</td><td headers="hd_h_ml302.tu2_1_7_1_2 hd_h_ml302.tu2_1_7_2_9 hd_h_ml302.tu2_1_7_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_7_1_2 hd_h_ml302.tu2_1_7_2_9 hd_h_ml302.tu2_1_7_3_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_7_1_2 hd_h_ml302.tu2_1_7_2_10 hd_h_ml302.tu2_1_7_3_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">>50</td><td headers="hd_h_ml302.tu2_1_7_1_2 hd_h_ml302.tu2_1_7_2_10 hd_h_ml302.tu2_1_7_3_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">2X</td></tr><tr><td headers="hd_h_ml302.tu2_1_7_1_1 hd_h_ml302.tu2_1_7_2_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Analog 62</td><td headers="hd_h_ml302.tu2_1_7_1_1 hd_h_ml302.tu2_1_7_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-03000002522-1</td><td headers="hd_h_ml302.tu2_1_7_1_1 hd_h_ml302.tu2_1_7_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">
|
||
<div class="graphic"><img src="/books/NBK143563/bin/ml302fu64.jpg" alt="Image ml302fu64.jpg" /></div></td><td headers="hd_h_ml302.tu2_1_7_1_1 hd_h_ml302.tu2_1_7_2_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">13337884</td><td headers="hd_h_ml302.tu2_1_7_1_1 hd_h_ml302.tu2_1_7_2_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/125258652" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">125258652</a></td><td headers="hd_h_ml302.tu2_1_7_1_1 hd_h_ml302.tu2_1_7_2_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_7_1_1 hd_h_ml302.tu2_1_7_2_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">TSRI</td><td headers="hd_h_ml302.tu2_1_7_1_1 hd_h_ml302.tu2_1_7_2_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">None</td><td headers="hd_h_ml302.tu2_1_7_1_2 hd_h_ml302.tu2_1_7_2_9 hd_h_ml302.tu2_1_7_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_7_1_2 hd_h_ml302.tu2_1_7_2_9 hd_h_ml302.tu2_1_7_3_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_7_1_2 hd_h_ml302.tu2_1_7_2_10 hd_h_ml302.tu2_1_7_3_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">>50</td><td headers="hd_h_ml302.tu2_1_7_1_2 hd_h_ml302.tu2_1_7_2_10 hd_h_ml302.tu2_1_7_3_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">2X</td></tr><tr><td headers="hd_h_ml302.tu2_1_7_1_1 hd_h_ml302.tu2_1_7_2_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Analog 63</td><td headers="hd_h_ml302.tu2_1_7_1_1 hd_h_ml302.tu2_1_7_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-03000002523-1</td><td headers="hd_h_ml302.tu2_1_7_1_1 hd_h_ml302.tu2_1_7_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">
|
||
<div class="graphic"><img src="/books/NBK143563/bin/ml302fu65.jpg" alt="Image ml302fu65.jpg" /></div></td><td headers="hd_h_ml302.tu2_1_7_1_1 hd_h_ml302.tu2_1_7_2_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">1201949</td><td headers="hd_h_ml302.tu2_1_7_1_1 hd_h_ml302.tu2_1_7_2_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/125258653" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">125258653</a></td><td headers="hd_h_ml302.tu2_1_7_1_1 hd_h_ml302.tu2_1_7_2_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_7_1_1 hd_h_ml302.tu2_1_7_2_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">TSRI</td><td headers="hd_h_ml302.tu2_1_7_1_1 hd_h_ml302.tu2_1_7_2_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">None</td><td headers="hd_h_ml302.tu2_1_7_1_2 hd_h_ml302.tu2_1_7_2_9 hd_h_ml302.tu2_1_7_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_7_1_2 hd_h_ml302.tu2_1_7_2_9 hd_h_ml302.tu2_1_7_3_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_7_1_2 hd_h_ml302.tu2_1_7_2_10 hd_h_ml302.tu2_1_7_3_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">>50</td><td headers="hd_h_ml302.tu2_1_7_1_2 hd_h_ml302.tu2_1_7_2_10 hd_h_ml302.tu2_1_7_3_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td></tr><tr><td headers="hd_h_ml302.tu2_1_7_1_1 hd_h_ml302.tu2_1_7_2_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Analog 64</td><td headers="hd_h_ml302.tu2_1_7_1_1 hd_h_ml302.tu2_1_7_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-03000002524-1</td><td headers="hd_h_ml302.tu2_1_7_1_1 hd_h_ml302.tu2_1_7_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">
|
||
<div class="graphic"><img src="/books/NBK143563/bin/ml302fu66.jpg" alt="Image ml302fu66.jpg" /></div></td><td headers="hd_h_ml302.tu2_1_7_1_1 hd_h_ml302.tu2_1_7_2_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">1201311</td><td headers="hd_h_ml302.tu2_1_7_1_1 hd_h_ml302.tu2_1_7_2_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/125258654" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">125258654</a></td><td headers="hd_h_ml302.tu2_1_7_1_1 hd_h_ml302.tu2_1_7_2_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_7_1_1 hd_h_ml302.tu2_1_7_2_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">TSRI</td><td headers="hd_h_ml302.tu2_1_7_1_1 hd_h_ml302.tu2_1_7_2_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">None</td><td headers="hd_h_ml302.tu2_1_7_1_2 hd_h_ml302.tu2_1_7_2_9 hd_h_ml302.tu2_1_7_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_7_1_2 hd_h_ml302.tu2_1_7_2_9 hd_h_ml302.tu2_1_7_3_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_7_1_2 hd_h_ml302.tu2_1_7_2_10 hd_h_ml302.tu2_1_7_3_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">>50</td><td headers="hd_h_ml302.tu2_1_7_1_2 hd_h_ml302.tu2_1_7_2_10 hd_h_ml302.tu2_1_7_3_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td></tr><tr><td headers="hd_h_ml302.tu2_1_7_1_1 hd_h_ml302.tu2_1_7_2_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Analog 65</td><td headers="hd_h_ml302.tu2_1_7_1_1 hd_h_ml302.tu2_1_7_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-03000002525-1</td><td headers="hd_h_ml302.tu2_1_7_1_1 hd_h_ml302.tu2_1_7_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">
|
||
<div class="graphic"><img src="/books/NBK143563/bin/ml302fu67.jpg" alt="Image ml302fu67.jpg" /></div></td><td headers="hd_h_ml302.tu2_1_7_1_1 hd_h_ml302.tu2_1_7_2_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">5943467</td><td headers="hd_h_ml302.tu2_1_7_1_1 hd_h_ml302.tu2_1_7_2_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/125258655" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">125258655</a></td><td headers="hd_h_ml302.tu2_1_7_1_1 hd_h_ml302.tu2_1_7_2_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_7_1_1 hd_h_ml302.tu2_1_7_2_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">TSRI</td><td headers="hd_h_ml302.tu2_1_7_1_1 hd_h_ml302.tu2_1_7_2_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">None</td><td headers="hd_h_ml302.tu2_1_7_1_2 hd_h_ml302.tu2_1_7_2_9 hd_h_ml302.tu2_1_7_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_7_1_2 hd_h_ml302.tu2_1_7_2_9 hd_h_ml302.tu2_1_7_3_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_7_1_2 hd_h_ml302.tu2_1_7_2_10 hd_h_ml302.tu2_1_7_3_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">>50</td><td headers="hd_h_ml302.tu2_1_7_1_2 hd_h_ml302.tu2_1_7_2_10 hd_h_ml302.tu2_1_7_3_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td></tr><tr><td headers="hd_h_ml302.tu2_1_7_1_1 hd_h_ml302.tu2_1_7_2_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Analog 66</td><td headers="hd_h_ml302.tu2_1_7_1_1 hd_h_ml302.tu2_1_7_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-03000002526-1</td><td headers="hd_h_ml302.tu2_1_7_1_1 hd_h_ml302.tu2_1_7_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">
|
||
<div class="graphic"><img src="/books/NBK143563/bin/ml302fu68.jpg" alt="Image ml302fu68.jpg" /></div></td><td headers="hd_h_ml302.tu2_1_7_1_1 hd_h_ml302.tu2_1_7_2_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">53356622</td><td headers="hd_h_ml302.tu2_1_7_1_1 hd_h_ml302.tu2_1_7_2_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/125258656" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">125258656</a></td><td headers="hd_h_ml302.tu2_1_7_1_1 hd_h_ml302.tu2_1_7_2_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_7_1_1 hd_h_ml302.tu2_1_7_2_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">TSRI</td><td headers="hd_h_ml302.tu2_1_7_1_1 hd_h_ml302.tu2_1_7_2_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">None</td><td headers="hd_h_ml302.tu2_1_7_1_2 hd_h_ml302.tu2_1_7_2_9 hd_h_ml302.tu2_1_7_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_7_1_2 hd_h_ml302.tu2_1_7_2_9 hd_h_ml302.tu2_1_7_3_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_7_1_2 hd_h_ml302.tu2_1_7_2_10 hd_h_ml302.tu2_1_7_3_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">>50</td><td headers="hd_h_ml302.tu2_1_7_1_2 hd_h_ml302.tu2_1_7_2_10 hd_h_ml302.tu2_1_7_3_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td></tr><tr><td headers="hd_h_ml302.tu2_1_7_1_1 hd_h_ml302.tu2_1_7_2_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Analog 67</td><td headers="hd_h_ml302.tu2_1_7_1_1 hd_h_ml302.tu2_1_7_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-03000002527-1</td><td headers="hd_h_ml302.tu2_1_7_1_1 hd_h_ml302.tu2_1_7_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">
|
||
<div class="graphic"><img src="/books/NBK143563/bin/ml302fu69.jpg" alt="Image ml302fu69.jpg" /></div></td><td headers="hd_h_ml302.tu2_1_7_1_1 hd_h_ml302.tu2_1_7_2_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">53356627</td><td headers="hd_h_ml302.tu2_1_7_1_1 hd_h_ml302.tu2_1_7_2_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/125258657" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">125258657</a></td><td headers="hd_h_ml302.tu2_1_7_1_1 hd_h_ml302.tu2_1_7_2_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_7_1_1 hd_h_ml302.tu2_1_7_2_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">TSRI</td><td headers="hd_h_ml302.tu2_1_7_1_1 hd_h_ml302.tu2_1_7_2_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">None</td><td headers="hd_h_ml302.tu2_1_7_1_2 hd_h_ml302.tu2_1_7_2_9 hd_h_ml302.tu2_1_7_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_7_1_2 hd_h_ml302.tu2_1_7_2_9 hd_h_ml302.tu2_1_7_3_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_7_1_2 hd_h_ml302.tu2_1_7_2_10 hd_h_ml302.tu2_1_7_3_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">>50</td><td headers="hd_h_ml302.tu2_1_7_1_2 hd_h_ml302.tu2_1_7_2_10 hd_h_ml302.tu2_1_7_3_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">2X</td></tr><tr><td headers="hd_h_ml302.tu2_1_7_1_1 hd_h_ml302.tu2_1_7_2_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Analog 68</td><td headers="hd_h_ml302.tu2_1_7_1_1 hd_h_ml302.tu2_1_7_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-03000002528-1</td><td headers="hd_h_ml302.tu2_1_7_1_1 hd_h_ml302.tu2_1_7_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">
|
||
<div class="graphic"><img src="/books/NBK143563/bin/ml302fu70.jpg" alt="Image ml302fu70.jpg" /></div></td><td headers="hd_h_ml302.tu2_1_7_1_1 hd_h_ml302.tu2_1_7_2_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">53356652</td><td headers="hd_h_ml302.tu2_1_7_1_1 hd_h_ml302.tu2_1_7_2_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/125258658" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">125258658</a></td><td headers="hd_h_ml302.tu2_1_7_1_1 hd_h_ml302.tu2_1_7_2_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_7_1_1 hd_h_ml302.tu2_1_7_2_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">TSRI</td><td headers="hd_h_ml302.tu2_1_7_1_1 hd_h_ml302.tu2_1_7_2_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">None</td><td headers="hd_h_ml302.tu2_1_7_1_2 hd_h_ml302.tu2_1_7_2_9 hd_h_ml302.tu2_1_7_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_7_1_2 hd_h_ml302.tu2_1_7_2_9 hd_h_ml302.tu2_1_7_3_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_7_1_2 hd_h_ml302.tu2_1_7_2_10 hd_h_ml302.tu2_1_7_3_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">>50</td><td headers="hd_h_ml302.tu2_1_7_1_2 hd_h_ml302.tu2_1_7_2_10 hd_h_ml302.tu2_1_7_3_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">2X</td></tr><tr><td headers="hd_h_ml302.tu2_1_7_1_1 hd_h_ml302.tu2_1_7_2_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Analog 69</td><td headers="hd_h_ml302.tu2_1_7_1_1 hd_h_ml302.tu2_1_7_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-03000002529-1</td><td headers="hd_h_ml302.tu2_1_7_1_1 hd_h_ml302.tu2_1_7_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">
|
||
<div class="graphic"><img src="/books/NBK143563/bin/ml302fu71.jpg" alt="Image ml302fu71.jpg" /></div></td><td headers="hd_h_ml302.tu2_1_7_1_1 hd_h_ml302.tu2_1_7_2_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">53356632</td><td headers="hd_h_ml302.tu2_1_7_1_1 hd_h_ml302.tu2_1_7_2_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/125258660" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">125258660</a></td><td headers="hd_h_ml302.tu2_1_7_1_1 hd_h_ml302.tu2_1_7_2_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_7_1_1 hd_h_ml302.tu2_1_7_2_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">TSRI</td><td headers="hd_h_ml302.tu2_1_7_1_1 hd_h_ml302.tu2_1_7_2_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">None</td><td headers="hd_h_ml302.tu2_1_7_1_2 hd_h_ml302.tu2_1_7_2_9 hd_h_ml302.tu2_1_7_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_7_1_2 hd_h_ml302.tu2_1_7_2_9 hd_h_ml302.tu2_1_7_3_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_7_1_2 hd_h_ml302.tu2_1_7_2_10 hd_h_ml302.tu2_1_7_3_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">6.25</td><td headers="hd_h_ml302.tu2_1_7_1_2 hd_h_ml302.tu2_1_7_2_10 hd_h_ml302.tu2_1_7_3_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">16X</td></tr></tbody></table><table><thead><tr><th id="hd_h_ml302.tu2_1_8_1_1" colspan="8" rowspan="1" style="text-align:center;vertical-align:middle;">Compound Information</th><th id="hd_h_ml302.tu2_1_8_1_2" colspan="9" rowspan="1" style="text-align:center;vertical-align:middle;">Bacterial Assays (Strain and MBL)</th></tr><tr><th headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_1" id="hd_h_ml302.tu2_1_8_2_1" rowspan="2" colspan="1" style="text-align:center;vertical-align:middle;">Compound</th><th headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_2" id="hd_h_ml302.tu2_1_8_2_2" rowspan="2" colspan="1" style="text-align:center;vertical-align:middle;">SR-Number</th><th headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_3" id="hd_h_ml302.tu2_1_8_2_3" rowspan="2" colspan="1" style="text-align:center;vertical-align:middle;">Structure</th><th headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_4" id="hd_h_ml302.tu2_1_8_2_4" rowspan="2" colspan="1" style="text-align:center;vertical-align:middle;">CID</th><th headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_5" id="hd_h_ml302.tu2_1_8_2_5" rowspan="2" colspan="1" style="text-align:center;vertical-align:middle;">SID</th><th headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_6" id="hd_h_ml302.tu2_1_8_2_6" rowspan="2" colspan="1" style="text-align:center;vertical-align:middle;">MLS</th><th headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_7" id="hd_h_ml302.tu2_1_8_2_7" rowspan="2" colspan="1" style="text-align:center;vertical-align:middle;">Vendor</th><th headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_8" id="hd_h_ml302.tu2_1_8_2_8" rowspan="2" colspan="1" style="text-align:center;vertical-align:middle;">Vendor Catalog ID</th><th headers="hd_h_ml302.tu2_1_8_1_2" id="hd_h_ml302.tu2_1_8_2_9" colspan="2" rowspan="1" style="text-align:center;vertical-align:middle;">BL21 (VIM-2)</th><th headers="hd_h_ml302.tu2_1_8_1_2" id="hd_h_ml302.tu2_1_8_2_10" colspan="2" rowspan="1" style="text-align:center;vertical-align:middle;">YMC07/B3323 (VIM-2)</th><th headers="hd_h_ml302.tu2_1_8_1_2" id="hd_h_ml302.tu2_1_8_2_11" colspan="2" rowspan="1" style="text-align:center;vertical-align:middle;">BAA-2146 (NDM-1)</th><th headers="hd_h_ml302.tu2_1_8_1_2" id="hd_h_ml302.tu2_1_8_2_12" colspan="2" rowspan="1" style="text-align:center;vertical-align:middle;">PA641 (VIM-2)</th><th headers="hd_h_ml302.tu2_1_8_1_2" id="hd_h_ml302.tu2_1_8_2_13" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">KN20</th></tr><tr><th headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_9" id="hd_h_ml302.tu2_1_8_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">MIC 4x (μM)</th><th headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_9" id="hd_h_ml302.tu2_1_8_3_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Imipenem Potentiation</th><th headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_10" id="hd_h_ml302.tu2_1_8_3_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">MIC 4x (μM)</th><th headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_10" id="hd_h_ml302.tu2_1_8_3_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Imipenem Potentiation</th><th headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_11" id="hd_h_ml302.tu2_1_8_3_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">MIC 4x (μM)</th><th headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_11" id="hd_h_ml302.tu2_1_8_3_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Imipenem Potentiation</th><th headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_12" id="hd_h_ml302.tu2_1_8_3_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">MIC 4x (μM)</th><th headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_12" id="hd_h_ml302.tu2_1_8_3_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Imipenem Potentiation</th><th headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_13" id="hd_h_ml302.tu2_1_8_3_9" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">MIC 4x (μM)</th></tr></thead><tbody><tr><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Analog 70</td><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-03000002530-1</td><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">
|
||
<div class="graphic"><img src="/books/NBK143563/bin/ml302fu72.jpg" alt="Image ml302fu72.jpg" /></div></td><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">53356630</td><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/125258661" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">125258661</a></td><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">TSRI</td><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">None</td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_9 hd_h_ml302.tu2_1_8_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_9 hd_h_ml302.tu2_1_8_3_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_10 hd_h_ml302.tu2_1_8_3_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">6.25</td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_10 hd_h_ml302.tu2_1_8_3_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">16X</td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_11 hd_h_ml302.tu2_1_8_3_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_11 hd_h_ml302.tu2_1_8_3_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_12 hd_h_ml302.tu2_1_8_3_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_12 hd_h_ml302.tu2_1_8_3_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_13 hd_h_ml302.tu2_1_8_3_9" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td></tr><tr><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Analog 71</td><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-03000002531-1</td><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">
|
||
<div class="graphic"><img src="/books/NBK143563/bin/ml302fu73.jpg" alt="Image ml302fu73.jpg" /></div></td><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">53356624</td><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/125258662" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">125258662</a></td><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">TSRI</td><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">None</td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_9 hd_h_ml302.tu2_1_8_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_9 hd_h_ml302.tu2_1_8_3_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_10 hd_h_ml302.tu2_1_8_3_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">6.25</td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_10 hd_h_ml302.tu2_1_8_3_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">8X</td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_11 hd_h_ml302.tu2_1_8_3_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_11 hd_h_ml302.tu2_1_8_3_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_12 hd_h_ml302.tu2_1_8_3_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_12 hd_h_ml302.tu2_1_8_3_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_13 hd_h_ml302.tu2_1_8_3_9" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td></tr><tr><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Analog 72</td><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-03000002586-1</td><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">
|
||
<div class="graphic"><img src="/books/NBK143563/bin/ml302fu74.jpg" alt="Image ml302fu74.jpg" /></div></td><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">53384688</td><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/125311270" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">125311270</a></td><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">TSRI</td><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">None</td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_9 hd_h_ml302.tu2_1_8_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">25</td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_9 hd_h_ml302.tu2_1_8_3_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">8X</td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_10 hd_h_ml302.tu2_1_8_3_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">25</td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_10 hd_h_ml302.tu2_1_8_3_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">2x</td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_11 hd_h_ml302.tu2_1_8_3_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">>50</td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_11 hd_h_ml302.tu2_1_8_3_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_12 hd_h_ml302.tu2_1_8_3_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_12 hd_h_ml302.tu2_1_8_3_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_13 hd_h_ml302.tu2_1_8_3_9" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">>50</td></tr><tr><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Analog 73</td><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-01000199849-2</td><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">
|
||
<div class="graphic"><img src="/books/NBK143563/bin/ml302fu75.jpg" alt="Image ml302fu75.jpg" /></div></td><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">1381767</td><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/125258650" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">125258650</a></td><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">TSRI</td><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">None</td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_9 hd_h_ml302.tu2_1_8_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_9 hd_h_ml302.tu2_1_8_3_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_10 hd_h_ml302.tu2_1_8_3_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">>50</td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_10 hd_h_ml302.tu2_1_8_3_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_11 hd_h_ml302.tu2_1_8_3_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_11 hd_h_ml302.tu2_1_8_3_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_12 hd_h_ml302.tu2_1_8_3_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_12 hd_h_ml302.tu2_1_8_3_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_13 hd_h_ml302.tu2_1_8_3_9" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td></tr><tr><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Analog 74</td><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-01000214156-2</td><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">
|
||
<div class="graphic"><img src="/books/NBK143563/bin/ml302fu76.jpg" alt="Image ml302fu76.jpg" /></div></td><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">1201186</td><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/125258659" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">125258659</a></td><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">TSRI</td><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">None</td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_9 hd_h_ml302.tu2_1_8_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_9 hd_h_ml302.tu2_1_8_3_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_10 hd_h_ml302.tu2_1_8_3_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">>50</td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_10 hd_h_ml302.tu2_1_8_3_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">2X</td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_11 hd_h_ml302.tu2_1_8_3_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_11 hd_h_ml302.tu2_1_8_3_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_12 hd_h_ml302.tu2_1_8_3_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_12 hd_h_ml302.tu2_1_8_3_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_13 hd_h_ml302.tu2_1_8_3_9" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td></tr><tr><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Analog 75</td><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-01000686826-3</td><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">
|
||
<div class="graphic"><img src="/books/NBK143563/bin/ml302fu77.jpg" alt="Image ml302fu77.jpg" /></div></td><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">1594367</td><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/125001878" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">125001878</a></td><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Vitas-M Lab</td><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">STK994030</td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_9 hd_h_ml302.tu2_1_8_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">50</td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_9 hd_h_ml302.tu2_1_8_3_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_10 hd_h_ml302.tu2_1_8_3_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_10 hd_h_ml302.tu2_1_8_3_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_11 hd_h_ml302.tu2_1_8_3_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_11 hd_h_ml302.tu2_1_8_3_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_12 hd_h_ml302.tu2_1_8_3_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_12 hd_h_ml302.tu2_1_8_3_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_13 hd_h_ml302.tu2_1_8_3_9" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td></tr><tr><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Analog 76</td><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-01000699784-2</td><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">
|
||
<div class="graphic"><img src="/books/NBK143563/bin/ml302fu78.jpg" alt="Image ml302fu78.jpg" /></div></td><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">1553748</td><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/125001882" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">125001882</a></td><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Vitas-M Lab</td><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">STL035275</td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_9 hd_h_ml302.tu2_1_8_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">100</td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_9 hd_h_ml302.tu2_1_8_3_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_10 hd_h_ml302.tu2_1_8_3_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_10 hd_h_ml302.tu2_1_8_3_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_11 hd_h_ml302.tu2_1_8_3_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_11 hd_h_ml302.tu2_1_8_3_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_12 hd_h_ml302.tu2_1_8_3_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_12 hd_h_ml302.tu2_1_8_3_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_13 hd_h_ml302.tu2_1_8_3_9" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td></tr><tr><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Analog 77</td><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-03000002543-1</td><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">
|
||
<div class="graphic"><img src="/books/NBK143563/bin/ml302fu79.jpg" alt="Image ml302fu79.jpg" /></div></td><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">53361995</td><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/125264843" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">125264843</a></td><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">TSRI</td><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">None</td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_9 hd_h_ml302.tu2_1_8_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_9 hd_h_ml302.tu2_1_8_3_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_10 hd_h_ml302.tu2_1_8_3_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">50</td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_10 hd_h_ml302.tu2_1_8_3_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">4X</td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_11 hd_h_ml302.tu2_1_8_3_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_11 hd_h_ml302.tu2_1_8_3_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_12 hd_h_ml302.tu2_1_8_3_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_12 hd_h_ml302.tu2_1_8_3_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_13 hd_h_ml302.tu2_1_8_3_9" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td></tr><tr><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Analog 78</td><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-03000002544-1</td><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">
|
||
<div class="graphic"><img src="/books/NBK143563/bin/ml302fu80.jpg" alt="Image ml302fu80.jpg" /></div></td><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">53361997</td><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/125264844" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">125264844</a></td><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">TSRI</td><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">None</td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_9 hd_h_ml302.tu2_1_8_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_9 hd_h_ml302.tu2_1_8_3_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_10 hd_h_ml302.tu2_1_8_3_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">>50</td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_10 hd_h_ml302.tu2_1_8_3_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_11 hd_h_ml302.tu2_1_8_3_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_11 hd_h_ml302.tu2_1_8_3_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_12 hd_h_ml302.tu2_1_8_3_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_12 hd_h_ml302.tu2_1_8_3_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_13 hd_h_ml302.tu2_1_8_3_9" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td></tr><tr><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Analog 79</td><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-03000002545-1</td><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">
|
||
<div class="graphic"><img src="/books/NBK143563/bin/ml302fu81.jpg" alt="Image ml302fu81.jpg" /></div></td><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">53362020</td><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/125264845" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">125264845</a></td><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">TSRI</td><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">None</td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_9 hd_h_ml302.tu2_1_8_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_9 hd_h_ml302.tu2_1_8_3_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_10 hd_h_ml302.tu2_1_8_3_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">>50</td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_10 hd_h_ml302.tu2_1_8_3_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_11 hd_h_ml302.tu2_1_8_3_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_11 hd_h_ml302.tu2_1_8_3_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_12 hd_h_ml302.tu2_1_8_3_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_12 hd_h_ml302.tu2_1_8_3_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_13 hd_h_ml302.tu2_1_8_3_9" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td></tr><tr><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Analog 80</td><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-03000002546-1</td><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">
|
||
<div class="graphic"><img src="/books/NBK143563/bin/ml302fu82.jpg" alt="Image ml302fu82.jpg" /></div></td><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">53362005</td><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/125264846" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">125264846</a></td><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">TSRI</td><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">None</td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_9 hd_h_ml302.tu2_1_8_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_9 hd_h_ml302.tu2_1_8_3_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_10 hd_h_ml302.tu2_1_8_3_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">>50</td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_10 hd_h_ml302.tu2_1_8_3_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_11 hd_h_ml302.tu2_1_8_3_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_11 hd_h_ml302.tu2_1_8_3_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_12 hd_h_ml302.tu2_1_8_3_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_12 hd_h_ml302.tu2_1_8_3_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_13 hd_h_ml302.tu2_1_8_3_9" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td></tr><tr><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Analog 81</td><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-03000002547-1</td><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">
|
||
<div class="graphic"><img src="/books/NBK143563/bin/ml302fu83.jpg" alt="Image ml302fu83.jpg" /></div></td><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">53362003</td><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/125264847" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">125264847</a></td><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">TSRI</td><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">None</td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_9 hd_h_ml302.tu2_1_8_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_9 hd_h_ml302.tu2_1_8_3_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_10 hd_h_ml302.tu2_1_8_3_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">50</td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_10 hd_h_ml302.tu2_1_8_3_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">2X</td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_11 hd_h_ml302.tu2_1_8_3_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_11 hd_h_ml302.tu2_1_8_3_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_12 hd_h_ml302.tu2_1_8_3_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_12 hd_h_ml302.tu2_1_8_3_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_13 hd_h_ml302.tu2_1_8_3_9" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td></tr><tr><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Analog 82</td><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-03000002548-1</td><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">
|
||
<div class="graphic"><img src="/books/NBK143563/bin/ml302fu84.jpg" alt="Image ml302fu84.jpg" /></div></td><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">53362016</td><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/125264848" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">125264848</a></td><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">TSRI</td><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">None</td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_9 hd_h_ml302.tu2_1_8_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_9 hd_h_ml302.tu2_1_8_3_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_10 hd_h_ml302.tu2_1_8_3_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">25</td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_10 hd_h_ml302.tu2_1_8_3_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">4X</td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_11 hd_h_ml302.tu2_1_8_3_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_11 hd_h_ml302.tu2_1_8_3_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_12 hd_h_ml302.tu2_1_8_3_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_12 hd_h_ml302.tu2_1_8_3_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_13 hd_h_ml302.tu2_1_8_3_9" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td></tr><tr><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Analog 83</td><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-03000002549-1</td><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">
|
||
<div class="graphic"><img src="/books/NBK143563/bin/ml302fu85.jpg" alt="Image ml302fu85.jpg" /></div></td><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">53362008</td><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/125264849" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">125264849</a></td><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">TSRI</td><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">None</td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_9 hd_h_ml302.tu2_1_8_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_9 hd_h_ml302.tu2_1_8_3_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_10 hd_h_ml302.tu2_1_8_3_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">50</td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_10 hd_h_ml302.tu2_1_8_3_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">4X</td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_11 hd_h_ml302.tu2_1_8_3_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_11 hd_h_ml302.tu2_1_8_3_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_12 hd_h_ml302.tu2_1_8_3_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_12 hd_h_ml302.tu2_1_8_3_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_13 hd_h_ml302.tu2_1_8_3_9" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td></tr><tr><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Analog 84</td><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-03000002550-1</td><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">
|
||
<div class="graphic"><img src="/books/NBK143563/bin/ml302fu86.jpg" alt="Image ml302fu86.jpg" /></div></td><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">53362009</td><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/125264850" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">125264850</a></td><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">TSRI</td><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">None</td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_9 hd_h_ml302.tu2_1_8_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_9 hd_h_ml302.tu2_1_8_3_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_10 hd_h_ml302.tu2_1_8_3_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">>50</td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_10 hd_h_ml302.tu2_1_8_3_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_11 hd_h_ml302.tu2_1_8_3_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_11 hd_h_ml302.tu2_1_8_3_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_12 hd_h_ml302.tu2_1_8_3_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_12 hd_h_ml302.tu2_1_8_3_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_13 hd_h_ml302.tu2_1_8_3_9" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td></tr><tr><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Analog 85</td><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-03000002551-1</td><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">
|
||
<div class="graphic"><img src="/books/NBK143563/bin/ml302fu87.jpg" alt="Image ml302fu87.jpg" /></div></td><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">53362004</td><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/125264851" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">125264851</a></td><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">TSRI</td><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">None</td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_9 hd_h_ml302.tu2_1_8_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_9 hd_h_ml302.tu2_1_8_3_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_10 hd_h_ml302.tu2_1_8_3_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">50</td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_10 hd_h_ml302.tu2_1_8_3_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">2X</td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_11 hd_h_ml302.tu2_1_8_3_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_11 hd_h_ml302.tu2_1_8_3_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_12 hd_h_ml302.tu2_1_8_3_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_12 hd_h_ml302.tu2_1_8_3_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_13 hd_h_ml302.tu2_1_8_3_9" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td></tr><tr><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Analog 86</td><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-03000002552-1</td><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">
|
||
<div class="graphic"><img src="/books/NBK143563/bin/ml302fu88.jpg" alt="Image ml302fu88.jpg" /></div></td><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">53362006</td><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/125264852" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">125264852</a></td><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">TSRI</td><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">None</td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_9 hd_h_ml302.tu2_1_8_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_9 hd_h_ml302.tu2_1_8_3_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_10 hd_h_ml302.tu2_1_8_3_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">50</td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_10 hd_h_ml302.tu2_1_8_3_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">2X</td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_11 hd_h_ml302.tu2_1_8_3_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_11 hd_h_ml302.tu2_1_8_3_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_12 hd_h_ml302.tu2_1_8_3_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_12 hd_h_ml302.tu2_1_8_3_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_13 hd_h_ml302.tu2_1_8_3_9" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td></tr><tr><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Analog 87</td><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-03000002553-1</td><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">
|
||
<div class="graphic"><img src="/books/NBK143563/bin/ml302fu89.jpg" alt="Image ml302fu89.jpg" /></div></td><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">53362014</td><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/125264853" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">125264853</a></td><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">TSRI</td><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">None</td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_9 hd_h_ml302.tu2_1_8_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_9 hd_h_ml302.tu2_1_8_3_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_10 hd_h_ml302.tu2_1_8_3_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">25</td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_10 hd_h_ml302.tu2_1_8_3_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">4X</td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_11 hd_h_ml302.tu2_1_8_3_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_11 hd_h_ml302.tu2_1_8_3_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_12 hd_h_ml302.tu2_1_8_3_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_12 hd_h_ml302.tu2_1_8_3_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_13 hd_h_ml302.tu2_1_8_3_9" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td></tr><tr><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Analog 88</td><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-03000002554-1</td><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">
|
||
<div class="graphic"><img src="/books/NBK143563/bin/ml302fu90.jpg" alt="Image ml302fu90.jpg" /></div></td><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">53362019</td><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/125264854" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">125264854</a></td><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">TSRI</td><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">None</td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_9 hd_h_ml302.tu2_1_8_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">12.5</td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_9 hd_h_ml302.tu2_1_8_3_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_10 hd_h_ml302.tu2_1_8_3_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">3.125</td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_10 hd_h_ml302.tu2_1_8_3_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">32X</td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_11 hd_h_ml302.tu2_1_8_3_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">>50</td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_11 hd_h_ml302.tu2_1_8_3_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">2X</td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_12 hd_h_ml302.tu2_1_8_3_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">>50</td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_12 hd_h_ml302.tu2_1_8_3_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_13 hd_h_ml302.tu2_1_8_3_9" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">>50</td></tr><tr><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Analog 89</td><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-03000002556-1</td><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">
|
||
<div class="graphic"><img src="/books/NBK143563/bin/ml302fu91.jpg" alt="Image ml302fu91.jpg" /></div></td><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">53362002</td><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/125264856" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">125264856</a></td><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">TSRI</td><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">None</td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_9 hd_h_ml302.tu2_1_8_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">1.563</td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_9 hd_h_ml302.tu2_1_8_3_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">8X</td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_10 hd_h_ml302.tu2_1_8_3_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">3.125</td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_10 hd_h_ml302.tu2_1_8_3_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">32X</td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_11 hd_h_ml302.tu2_1_8_3_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">>50</td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_11 hd_h_ml302.tu2_1_8_3_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">2X</td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_12 hd_h_ml302.tu2_1_8_3_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">50</td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_12 hd_h_ml302.tu2_1_8_3_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">4X</td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_13 hd_h_ml302.tu2_1_8_3_9" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">>50</td></tr><tr><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Analog 90</td><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-03000002557-1</td><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">
|
||
<div class="graphic"><img src="/books/NBK143563/bin/ml302fu92.jpg" alt="Image ml302fu92.jpg" /></div></td><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">53362007</td><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/125264857" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">125264857</a></td><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">TSRI</td><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">None</td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_9 hd_h_ml302.tu2_1_8_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0.781</td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_9 hd_h_ml302.tu2_1_8_3_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">8X</td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_10 hd_h_ml302.tu2_1_8_3_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">3.125</td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_10 hd_h_ml302.tu2_1_8_3_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">16X</td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_11 hd_h_ml302.tu2_1_8_3_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">>50</td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_11 hd_h_ml302.tu2_1_8_3_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">2X</td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_12 hd_h_ml302.tu2_1_8_3_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">>50</td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_12 hd_h_ml302.tu2_1_8_3_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">2X</td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_13 hd_h_ml302.tu2_1_8_3_9" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">>50</td></tr><tr><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Analog 91</td><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-03000002587-1</td><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">
|
||
<div class="graphic"><img src="/books/NBK143563/bin/ml302fu93.jpg" alt="Image ml302fu93.jpg" /></div></td><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">53384696</td><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/125311271" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">125311271</a></td><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">TSRI</td><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">None</td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_9 hd_h_ml302.tu2_1_8_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">25</td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_9 hd_h_ml302.tu2_1_8_3_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">8X</td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_10 hd_h_ml302.tu2_1_8_3_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">3.125</td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_10 hd_h_ml302.tu2_1_8_3_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">2X</td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_11 hd_h_ml302.tu2_1_8_3_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">>50</td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_11 hd_h_ml302.tu2_1_8_3_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">2X</td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_12 hd_h_ml302.tu2_1_8_3_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">>50</td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_12 hd_h_ml302.tu2_1_8_3_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_13 hd_h_ml302.tu2_1_8_3_9" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">>50</td></tr><tr><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Analog 92</td><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-03000002673-1</td><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">
|
||
<div class="graphic"><img src="/books/NBK143563/bin/ml302fu94.jpg" alt="Image ml302fu94.jpg" /></div></td><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">53495084</td><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/126723254" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">126723254</a></td><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">TSRI</td><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">None</td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_9 hd_h_ml302.tu2_1_8_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_9 hd_h_ml302.tu2_1_8_3_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_10 hd_h_ml302.tu2_1_8_3_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">3.125</td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_10 hd_h_ml302.tu2_1_8_3_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">16X</td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_11 hd_h_ml302.tu2_1_8_3_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">>50</td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_11 hd_h_ml302.tu2_1_8_3_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_12 hd_h_ml302.tu2_1_8_3_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">>50</td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_12 hd_h_ml302.tu2_1_8_3_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_13 hd_h_ml302.tu2_1_8_3_9" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">>50</td></tr><tr><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Analog 93</td><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-03000002706-1</td><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">
|
||
<div class="graphic"><img src="/books/NBK143563/bin/ml302fu95.jpg" alt="Image ml302fu95.jpg" /></div></td><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">54579793</td><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/131269028" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">131269028</a></td><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">TSRI</td><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">None</td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_9 hd_h_ml302.tu2_1_8_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_9 hd_h_ml302.tu2_1_8_3_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_10 hd_h_ml302.tu2_1_8_3_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">6.25</td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_10 hd_h_ml302.tu2_1_8_3_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">16X</td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_11 hd_h_ml302.tu2_1_8_3_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_11 hd_h_ml302.tu2_1_8_3_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_12 hd_h_ml302.tu2_1_8_3_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_12 hd_h_ml302.tu2_1_8_3_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_13 hd_h_ml302.tu2_1_8_3_9" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td></tr><tr><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Analog 94</td><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-03000002707-1</td><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">
|
||
<div class="graphic"><img src="/books/NBK143563/bin/ml302fu96.jpg" alt="Image ml302fu96.jpg" /></div></td><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">54579790</td><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/131269029" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">131269029</a></td><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">TSRI</td><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">None</td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_9 hd_h_ml302.tu2_1_8_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_9 hd_h_ml302.tu2_1_8_3_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_10 hd_h_ml302.tu2_1_8_3_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">>50</td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_10 hd_h_ml302.tu2_1_8_3_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_11 hd_h_ml302.tu2_1_8_3_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_11 hd_h_ml302.tu2_1_8_3_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_12 hd_h_ml302.tu2_1_8_3_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_12 hd_h_ml302.tu2_1_8_3_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_13 hd_h_ml302.tu2_1_8_3_9" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td></tr><tr><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Analog 95</td><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-03000002806-1</td><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">
|
||
<div class="graphic"><img src="/books/NBK143563/bin/ml302fu97.jpg" alt="Image ml302fu97.jpg" /></div></td><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">56596523</td><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/134228483" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">134228483</a></td><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">TSRI</td><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">None</td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_9 hd_h_ml302.tu2_1_8_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_9 hd_h_ml302.tu2_1_8_3_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_10 hd_h_ml302.tu2_1_8_3_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">1.563</td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_10 hd_h_ml302.tu2_1_8_3_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">32X</td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_11 hd_h_ml302.tu2_1_8_3_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_11 hd_h_ml302.tu2_1_8_3_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_12 hd_h_ml302.tu2_1_8_3_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_12 hd_h_ml302.tu2_1_8_3_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_13 hd_h_ml302.tu2_1_8_3_9" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td></tr><tr><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Analog 96</td><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-03000002807-1</td><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">
|
||
<div class="graphic"><img src="/books/NBK143563/bin/ml302fu98.jpg" alt="Image ml302fu98.jpg" /></div></td><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">56596515</td><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/134228484" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">134228484</a></td><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">TSRI</td><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">None</td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_9 hd_h_ml302.tu2_1_8_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_9 hd_h_ml302.tu2_1_8_3_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_10 hd_h_ml302.tu2_1_8_3_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">1.563</td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_10 hd_h_ml302.tu2_1_8_3_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">32X</td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_11 hd_h_ml302.tu2_1_8_3_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_11 hd_h_ml302.tu2_1_8_3_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_12 hd_h_ml302.tu2_1_8_3_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_12 hd_h_ml302.tu2_1_8_3_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_13 hd_h_ml302.tu2_1_8_3_9" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td></tr><tr><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Analog 97</td><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-03000002808-1</td><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">
|
||
<div class="graphic"><img src="/books/NBK143563/bin/ml302fu99.jpg" alt="Image ml302fu99.jpg" /></div></td><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">56596526</td><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/134228485" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">134228485</a></td><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">TSRI</td><td headers="hd_h_ml302.tu2_1_8_1_1 hd_h_ml302.tu2_1_8_2_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">None</td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_9 hd_h_ml302.tu2_1_8_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_9 hd_h_ml302.tu2_1_8_3_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_10 hd_h_ml302.tu2_1_8_3_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">1.563</td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_10 hd_h_ml302.tu2_1_8_3_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">32X</td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_11 hd_h_ml302.tu2_1_8_3_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_11 hd_h_ml302.tu2_1_8_3_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_12 hd_h_ml302.tu2_1_8_3_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_12 hd_h_ml302.tu2_1_8_3_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml302.tu2_1_8_1_2 hd_h_ml302.tu2_1_8_2_13 hd_h_ml302.tu2_1_8_3_9" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td></tr></tbody></table></div></div></div><div id="ml302.s13"><h3>3.5. Cellular Assays</h3><p>The probe was tested in a variety of bacterial assays performed by the assay provider to determine the probe’s selectivity, efficacy and mechanism of action.</p><p><i>MIC and Imipenem Antibiotic Synergy Assays [<a href="https://pubchem.ncbi.nlm.nih.gov/bioassay/624081" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">AID <u>624081</u></a> BL21 (VIM2); <a href="https://pubchem.ncbi.nlm.nih.gov/bioassay/624097" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">AID <u>624097</u></a> BL21 (IMP1); <a href="https://pubchem.ncbi.nlm.nih.gov/bioassay/624096" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">AID <u>624096</u></a> YMC07 (VIM2); <a href="https://pubchem.ncbi.nlm.nih.gov/bioassay/624082" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">AID <u>624082</u></a> BAA2146 (NDM1); <a href="https://pubchem.ncbi.nlm.nih.gov/bioassay/624080" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">AID <u>624080</u></a> PA641 (VIM2); <a href="https://pubchem.ncbi.nlm.nih.gov/bioassay/624095" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">AID <u>624095</u></a> KN20 (IMP1)].</i> Using a checkerboard microdilution method, probe <a href="/pcsubstance/?term=ML302[synonym]" ref="pagearea=body&targetsite=entrez&targetcat=term&targettype=pubchem">ML302</a> was tested for its ability to potentiate the efficacy of imipenem on VIM-2-expressing <i>E. coli</i> (BL21/VIM-2) [<a class="bk_pop" href="#ml302.r20">20</a>–<a class="bk_pop" href="#ml302.r22">22</a>]. The probe exhibited synergy with imipenem when present at concentrations as low as 3.13 μM, potentiating imipenem’s activity 8-fold. Significantly, probe <a href="/pcsubstance/?term=ML302[synonym]" ref="pagearea=body&targetsite=entrez&targetcat=term&targettype=pubchem">ML302</a> exhibited 32-fold imipenem potentiation in clinically relevant VIM-2-transformed <i>Acinetobacter</i> species YMC07/B3323: MIC range = 390–781 nM). Synergy was also observed by probe <a href="/pcsubstance/?term=ML302[synonym]" ref="pagearea=body&targetsite=entrez&targetcat=term&targettype=pubchem">ML302</a> in other clinical isolates including <i>K. pneumonia</i> BAA-2146 expressing NDM-1 [2-fold], <i>P. aeruginosa</i> expressing VIM-2 (PA641) [4-fold], and <i>P. aeruginosa</i> expressing IMP-1 (KN20) [2-fold].</p></div><div id="ml302.s14"><h3>3.6. Profiling Assays</h3><p>The identified VIM-2/IMP-1 inhibitor probe <a href="/pcsubstance/?term=ML302[synonym]" ref="pagearea=body&targetsite=entrez&targetcat=term&targettype=pubchem">ML302</a> was tested in biochemical and bacterial MIC assays to determine inhibition of VIM-2, IMP-1, TEM-1, AmpC, as well as assess its ability to potentiate the antibacterial activity of imipenem. Based on the results of these assays, it was agreed by the SRIMSC and assay provider that additional profiling was not required at this time.</p></div></div><div id="ml302.s15"><h2 id="_ml302_s15_">4. Discussion</h2><div id="ml302.s16"><h3>4.1. Comparison to existing art and how the new probe is an improvement</h3><p>Compared to our prior probe <a href="/pcsubstance/?term=ML121[synonym]" ref="pagearea=body&targetsite=entrez&targetcat=term&targettype=pubchem">ML121</a> and prior art mitoxantrone, the new probe <a href="/pcsubstance/?term=ML302[synonym]" ref="pagearea=body&targetsite=entrez&targetcat=term&targettype=pubchem">ML302</a> exhibits improved biochemical potency, antibacterial activity, and IMP-1 activity.</p><div id="ml302.t4" class="table"><h3><span class="label">Table 4</span><span class="title">Comparison of ML302 to existing Art</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK143563/table/ml302.t4/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ml302.t4_lrgtbl__"><table class="no_top_margin"><thead><tr><th id="hd_h_ml302.t4_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Name</th><th id="hd_h_ml302.t4_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Structure</th><th id="hd_h_ml302.t4_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR Number</th><th id="hd_h_ml302.t4_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">CID</th><th id="hd_h_ml302.t4_1_1_1_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SID</th><th id="hd_h_ml302.t4_1_1_1_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">MLS ID</th><th id="hd_h_ml302.t4_1_1_1_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">VIM-2 IC50</th><th id="hd_h_ml302.t4_1_1_1_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">IMP-1 IC50</th><th id="hd_h_ml302.t4_1_1_1_9" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">VIM-2 Ki</th><th id="hd_h_ml302.t4_1_1_1_10" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">TEM-1 IC50</th><th id="hd_h_ml302.t4_1_1_1_11" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">AmpC IC50</th><th id="hd_h_ml302.t4_1_1_1_12" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Synergy</th><th id="hd_h_ml302.t4_1_1_1_13" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">PubChem Activity</th></tr></thead><tbody><tr><td headers="hd_h_ml302.t4_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Probe <a href="/pcsubstance/?term=ML302[synonym]" ref="pagearea=body&targetsite=entrez&targetcat=term&targettype=pubchem">ML302</a></td><td headers="hd_h_ml302.t4_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">
|
||
<div class="graphic"><img src="/books/NBK143563/bin/ml302fu1.jpg" alt="Image ml302fu1.jpg" /></div></td><td headers="hd_h_ml302.t4_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-03000002555-2</td><td headers="hd_h_ml302.t4_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">53362017</td><td headers="hd_h_ml302.t4_1_1_1_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/134220672" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">134220672</a></td><td headers="hd_h_ml302.t4_1_1_1_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">MLS- 003940491</td><td headers="hd_h_ml302.t4_1_1_1_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">548 nM</td><td headers="hd_h_ml302.t4_1_1_1_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">3.02 μM</td><td headers="hd_h_ml302.t4_1_1_1_9" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">183 nM</td><td headers="hd_h_ml302.t4_1_1_1_10" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">>60 μM</td><td headers="hd_h_ml302.t4_1_1_1_11" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">>60 μM</td><td headers="hd_h_ml302.t4_1_1_1_12" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">3.125 μM (VIM-2)<br /><br />0.781 μM (IMP-1)<br /><br />(<a href="https://pubchem.ncbi.nlm.nih.gov/substance/125264855" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">SID 125264855</a>)</td><td headers="hd_h_ml302.t4_1_1_1_13" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">None</td></tr><tr><td headers="hd_h_ml302.t4_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Probe <a href="/pcsubstance/?term=ML121[synonym]" ref="pagearea=body&targetsite=entrez&targetcat=term&targettype=pubchem">ML121</a></td><td headers="hd_h_ml302.t4_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">
|
||
<div class="graphic"><img src="/books/NBK143563/bin/ml302fu100.jpg" alt="Image ml302fu100.jpg" /></div></td><td headers="hd_h_ml302.t4_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-01000775688-1</td><td headers="hd_h_ml302.t4_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">4870494</td><td headers="hd_h_ml302.t4_1_1_1_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/24790728" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">24790728</a> (MLSMR) ;<a href="https://pubchem.ncbi.nlm.nih.gov/substance/85856282" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">85856282</a> (purch); <a href="https://pubchem.ncbi.nlm.nih.gov/substance/103911139" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">103911139</a> (synth)</td><td headers="hd_h_ml302.t4_1_1_1_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">MLS-000680027</td><td headers="hd_h_ml302.t4_1_1_1_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">223 nM</td><td headers="hd_h_ml302.t4_1_1_1_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">>60 μM</td><td headers="hd_h_ml302.t4_1_1_1_9" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">148 nM</td><td headers="hd_h_ml302.t4_1_1_1_10" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">>60 μM</td><td headers="hd_h_ml302.t4_1_1_1_11" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.t4_1_1_1_12" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Active (12.5 μM) (TFA salt)</td><td headers="hd_h_ml302.t4_1_1_1_13" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">6/309 (1.9%)</td></tr><tr><td headers="hd_h_ml302.t4_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Prior art Mitoxantrone</td><td headers="hd_h_ml302.t4_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">
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<div class="graphic"><img src="/books/NBK143563/bin/ml302fu101.jpg" alt="Image ml302fu101.jpg" /></div></td><td headers="hd_h_ml302.t4_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-01000076001-7</td><td headers="hd_h_ml302.t4_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">4212(5458171)</td><td headers="hd_h_ml302.t4_1_1_1_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/56424031" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">56424031</a> (85856281)</td><td headers="hd_h_ml302.t4_1_1_1_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">MLS 001333711</td><td headers="hd_h_ml302.t4_1_1_1_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">powder 0.63 μM</td><td headers="hd_h_ml302.t4_1_1_1_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">> 56 μM</td><td headers="hd_h_ml302.t4_1_1_1_9" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">1.5 μM (non-competitive):</td><td headers="hd_h_ml302.t4_1_1_1_10" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">> 56 μM</td><td headers="hd_h_ml302.t4_1_1_1_11" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml302.t4_1_1_1_12" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Not applicable</td><td headers="hd_h_ml302.t4_1_1_1_13" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">40/139 (28.8%)</td></tr></tbody></table></div></div></div><div id="ml302.s17"><h3>4.2. Mechanism of Action Studies</h3><p>The assay provider has performed assays to elucidate the mode of inhibition and the probe’s inhibitory constant (Ki) against VIM-2 and IMP-1. The results of these probe development efforts determined that probe <a href="/pcsubstance/?term=ML302[synonym]" ref="pagearea=body&targetsite=entrez&targetcat=term&targettype=pubchem">ML302</a> is a non-selective, mixed mode inhibitor probe of the metallo-beta-lactamases VIM-2 and IMP-1 (<a class="figpopup" href="/books/NBK143563/figure/ml302.f6/?report=objectonly" target="object" rid-figpopup="figml302f6" rid-ob="figobml302f6">Figure 6</a>).</p><div class="iconblock whole_rhythm clearfix ten_col fig" id="figml302f6" co-legend-rid="figlgndml302f6"><a href="/books/NBK143563/figure/ml302.f6/?report=objectonly" target="object" title="Figure 6" class="img_link icnblk_img figpopup" rid-figpopup="figml302f6" rid-ob="figobml302f6"><img class="small-thumb" src="/books/NBK143563/bin/ml302f6.gif" src-large="/books/NBK143563/bin/ml302f6.jpg" alt="Figure 6. Mixed mode of inhibition for VIM-2 and IMP-1." /></a><div class="icnblk_cntnt" id="figlgndml302f6"><h4 id="ml302.f6"><a href="/books/NBK143563/figure/ml302.f6/?report=objectonly" target="object" rid-ob="figobml302f6">Figure 6</a></h4><p class="float-caption no_bottom_margin">Mixed mode of inhibition for VIM-2 and IMP-1. </p></div></div><p><i>VIM-2 and IMP-1 Ki Assays (<a href="https://pubchem.ncbi.nlm.nih.gov/bioassay/624083" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">AID <u>624083</u></a> and<a href="https://pubchem.ncbi.nlm.nih.gov/bioassay/624084" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">AID <u>624084</u></a>).</i> The purpose of these assays is to determine the inhibition constant (Ki) and modality of probe candidate molecules. Kinetic assays were conducted by incubating a range of nitrocefin substrate concentrations (100nM - 5 μM) with varying inhibitor concentrations and 0.1 nM enzyme at room temperature in buffer containing 50mM HEPES, 50μM ZnSO4, 0.05% Brij 35, pH 7.1. Absorbance was measured on a Tecan Safire<sup>2</sup> monochromatic microplate reader at 495 nm. Initial velocities were obtained from plots of absorbance at 495 nm versus time, using data points from only the linear portion of the hydrolysis curve. Substrate hydrolysis was continuously monitored. Initial velocities were plotted vs. substrate concentration and kinetic parameters were calculated using Graphpad Prism version 5.01 suite of programs. Mode of inhibition was determined using fit comparison capability of Graphpad Prism version 5.01 and additionally evaluated by Lineweaver-Burke plot. K<sub>i</sub> values were determined by non-linear regression analysis. The results of these studies demonstrated that probe <a href="/pcsubstance/?term=ML302[synonym]" ref="pagearea=body&targetsite=entrez&targetcat=term&targettype=pubchem">ML302</a> (CID 53362017) is a mixed mode uncompetitive and non-competitive inhibitor, with a submicromolar VIM-2 (183 ± 24 nM) and IMP-1 (930 ± 97 nM) K<sub>i</sub> values (<a class="figpopup" href="/books/NBK143563/figure/ml302.f6/?report=objectonly" target="object" rid-figpopup="figml302f6" rid-ob="figobml302f6">Figure 6</a>).</p><div id="ml302.t5" class="table"><h3><span class="label">Table 5</span><span class="title">K<sub>i</sub> values demonstrating ML302 is a mixed mode uncompetitive and non-competitive inhibitor</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK143563/table/ml302.t5/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ml302.t5_lrgtbl__"><table class="no_top_margin"><thead><tr><th id="hd_h_ml302.t5_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:bottom;">Probe</th><th id="hd_h_ml302.t5_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:bottom;">Corp ID</th><th id="hd_h_ml302.t5_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:bottom;">SID</th><th id="hd_h_ml302.t5_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:bottom;">CID</th><th id="hd_h_ml302.t5_1_1_1_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:bottom;">Modality</th><th id="hd_h_ml302.t5_1_1_1_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:bottom;">Vim-2 Ki, nM</th><th id="hd_h_ml302.t5_1_1_1_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:bottom;">IMP-1 Ki, nM</th></tr></thead><tbody><tr><td headers="hd_h_ml302.t5_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">New Probe <a href="/pcsubstance/?term=ML302[synonym]" ref="pagearea=body&targetsite=entrez&targetcat=term&targettype=pubchem">ML302</a></td><td headers="hd_h_ml302.t5_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">SR-03000002555-2</td><td headers="hd_h_ml302.t5_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/134220672" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">134220672</a></td><td headers="hd_h_ml302.t5_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">53362017</td><td headers="hd_h_ml302.t5_1_1_1_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">Mixed mode Inhibitor</td><td headers="hd_h_ml302.t5_1_1_1_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">183</td><td headers="hd_h_ml302.t5_1_1_1_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">930</td></tr><tr><td headers="hd_h_ml302.t5_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">Prior Probe <a href="/pcsubstance/?term=ML121[synonym]" ref="pagearea=body&targetsite=entrez&targetcat=term&targettype=pubchem">ML121</a></td><td headers="hd_h_ml302.t5_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">SR-01000775688-3</td><td headers="hd_h_ml302.t5_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/85856282" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">85856282</a></td><td headers="hd_h_ml302.t5_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">4870494</td><td headers="hd_h_ml302.t5_1_1_1_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">Non-competitive inhibition</td><td headers="hd_h_ml302.t5_1_1_1_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">148</td><td headers="hd_h_ml302.t5_1_1_1_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">ND</td></tr></tbody></table></div></div></div><div id="ml302.s18"><h3>4.3. Planned Future Studies</h3><p>The assay provider plans to determine the efficacy of probe <a href="/pcsubstance/?term=ML302[synonym]" ref="pagearea=body&targetsite=entrez&targetcat=term&targettype=pubchem">ML302</a> as well as prior probe <a href="/pcsubstance/?term=ML121[synonym]" ref="pagearea=body&targetsite=entrez&targetcat=term&targettype=pubchem">ML121</a> in eukaryotic cells and in animal models of bacterial infection. Additional studies will explore the SAR around the rhodanine scaffold.</p></div></div><div id="ml302.s19"><h2 id="_ml302_s19_">5. References</h2><dl class="temp-labeled-list"><dt>1.</dt><dd><div class="bk_ref" id="ml302.r1">Mazerski J, Martelli S, Borowski E. The geometry of intercalation complex of antitumor mitoxantrone and ametantrone with DNA: molecular dynamics simulations. <span><span class="ref-journal">Acta Biochim Pol. </span>1998;<span class="ref-vol">45</span>(1):1–11.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/9701490" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 9701490</span></a>]</div></dd><dt>2.</dt><dd><div class="bk_ref" id="ml302.r2">Minond D, Saldanha SA, Subramaniam P, Spaargaren M, Spicer T, Fotsing JR, Weide T, Fokin VV, Sharpless KB, Galleni M, Bebrone C, Lassaux P, Hodder P. Inhibitors of VIM-2 by screening pharmacologically active and click-chemistry compound libraries. <span><span class="ref-journal">Bioorg Med Chem. </span>2009;<span class="ref-vol">17</span>(14):5027–37.</span> [<a href="/pmc/articles/PMC2759276/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC2759276</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/19553129" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 19553129</span></a>]</div></dd><dt>3.</dt><dd><div class="bk_ref" id="ml302.r3">Siegel RE. Emerging gram-negative antibiotic resistance: daunting challenges, declining sensitivities, and dire consequences. <span><span class="ref-journal">Respir Care. </span>2008;<span class="ref-vol">53</span>(4):471–9.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/18364060" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 18364060</span></a>]</div></dd><dt>4.</dt><dd><div class="bk_ref" id="ml302.r4">Gupta V. An update on newer beta-lactamases. <span><span class="ref-journal">Indian J Med Res. </span>2007;<span class="ref-vol">126</span>(5):417–27.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/18160745" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 18160745</span></a>]</div></dd><dt>5.</dt><dd><div class="bk_ref" id="ml302.r5">Bradford PA. Extended-spectrum beta-lactamases in the 21st century: characterization, epidemiology, and detection of this important resistance threat. <span><span class="ref-journal">Clin Microbiol Rev. </span>2001;<span class="ref-vol">14</span>(4):933–51.</span> table of contents. [<a href="/pmc/articles/PMC89009/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC89009</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/11585791" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 11585791</span></a>]</div></dd><dt>6.</dt><dd><div class="bk_ref" id="ml302.r6">Sacha P, Wieczorek P, Hauschild T, Zorawski M, Olszanska D, Tryniszewska E. Metallo-beta-lactamases of Pseudomonas aeruginosa--a novel mechanism resistance to beta-lactam antibiotics. <span><span class="ref-journal">Folia Histochem Cytobiol. </span>2008;<span class="ref-vol">46</span>(2):137–42.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/18519228" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 18519228</span></a>]</div></dd><dt>7.</dt><dd><div class="bk_ref" id="ml302.r7">Koch AL. Bacterial wall as target for attack: past, present, and future research. <span><span class="ref-journal">Clin Microbiol Rev. </span>2003;<span class="ref-vol">16</span>(4):673–87.</span> [<a href="/pmc/articles/PMC207114/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC207114</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/14557293" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 14557293</span></a>]</div></dd><dt>8.</dt><dd><div class="bk_ref" id="ml302.r8">Jin W, Arakawa Y, Yasuzawa H, Taki T, Hashiguchi R, Mitsutani K, Shoga A, Yamaguchi Y, Kurosaki H, Shibata N, Ohta M, Goto M. Comparative study of the inhibition of metallo-beta-lactamases (IMP-1 and VIM-2) by thiol compounds that contain a hydrophobic group. <span><span class="ref-journal">Biol Pharm Bull. </span>2004;<span class="ref-vol">27</span>(6):851–6.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/15187432" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 15187432</span></a>]</div></dd><dt>9.</dt><dd><div class="bk_ref" id="ml302.r9">Abeylath SC, Turos E. Drug delivery approaches to overcome bacterial resistance to beta-lactam antibiotics. <span><span class="ref-journal">Expert Opin Drug Deliv. </span>2008;<span class="ref-vol">5</span>(9):931–49.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/18754746" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 18754746</span></a>]</div></dd><dt>10.</dt><dd><div class="bk_ref" id="ml302.r10">Wang Z, Fast W, Valentine AM, Benkovic SJ. Metallo-beta-lactamase: structure and mechanism. <span><span class="ref-journal">Curr Opin Chem Biol. </span>1999;<span class="ref-vol">3</span>(5):614–22.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/10508665" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 10508665</span></a>]</div></dd><dt>11.</dt><dd><div class="bk_ref" id="ml302.r11">Walsh TR, Toleman MA, Poirel L, Nordmann P. Metallo-beta-lactamases: the quiet before the storm? <span><span class="ref-journal">Clin Microbiol Rev. </span>2005;<span class="ref-vol">18</span>(2):306–25.</span> [<a href="/pmc/articles/PMC1082798/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC1082798</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/15831827" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 15831827</span></a>]</div></dd><dt>12.</dt><dd><div class="bk_ref" id="ml302.r12">Hirakata Y, Izumikawa K, Yamaguchi T, Takemura H, Tanaka H, Yoshida R, Matsuda J, Nakano M, Tomono K, Maesaki S, Kaku M, Yamada Y, Kamihira S, Kohno S. Rapid detection and evaluation of clinical characteristics of emerging multiple-drug-resistant gram-negative rods carrying the metallo-beta-lactamase gene blaIMP. <span><span class="ref-journal">Antimicrob Agents Chemother. </span>1998;<span class="ref-vol">42</span>(8):2006–11.</span> [<a href="/pmc/articles/PMC105724/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC105724</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/9687398" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 9687398</span></a>]</div></dd><dt>13.</dt><dd><div class="bk_ref" id="ml302.r13">Lauretti L, Riccio ML, Mazzariol A, Cornaglia G, Amicosante G, Fontana R, Rossolini GM. Cloning and characterization of blaVIM, a new integron-borne metallo-beta-lactamase gene from a Pseudomonas aeruginosa clinical isolate. <span><span class="ref-journal">Antimicrob Agents Chemother. </span>1999;<span class="ref-vol">43</span>(7):1584–90.</span> [<a href="/pmc/articles/PMC89328/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC89328</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/10390207" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 10390207</span></a>]</div></dd><dt>14.</dt><dd><div class="bk_ref" id="ml302.r14">Wang CX, Mi ZH. Imipenem-resistant Pseudomonas aeruginosa producing IMP-1 metallo-beta-lactamases and lacking the outer-membrane protein OprD. <span><span class="ref-journal">J Med Microbiol. </span>2006;<span class="ref-vol">55</span>(Pt 3):353–4.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/16476803" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 16476803</span></a>]</div></dd><dt>15.</dt><dd><div class="bk_ref" id="ml302.r15">Paterson DL, Bonomo RA. Extended-spectrum beta-lactamases: a clinical update. <span><span class="ref-journal">Clin Microbiol Rev. </span>2005;<span class="ref-vol">18</span>(4):657–86.</span> [<a href="/pmc/articles/PMC1265908/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC1265908</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/16223952" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 16223952</span></a>]</div></dd><dt>16.</dt><dd><div class="bk_ref" id="ml302.r16">Zuck P, O’Donnell GT, Cassaday J, Chase P, Hodder P, Strulovici B, Ferrer M. Miniaturization of absorbance assays using the fluorescent properties of white microplates. <span><span class="ref-journal">Anal Biochem. </span>2005;<span class="ref-vol">342</span>(2):254–9.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/15949786" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 15949786</span></a>]</div></dd><dt>17.</dt><dd><div class="bk_ref" id="ml302.r17">Li X, He Y, Ruiz CH, Koenig M, Cameron MD, Vojkovsky T. Characterization of dasatinib and its structural analogs as CYP3A4 mechanism-based inactivators and the proposed bioactivation pathways. <span><span class="ref-journal">Drug Metab Dispos. </span>2009;<span class="ref-vol">37</span>(6):1242–50.</span> [<a href="/pmc/articles/PMC3202349/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC3202349</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/19282395" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 19282395</span></a>]</div></dd><dt>18.</dt><dd><div class="bk_ref" id="ml302.r18">Li X, Kamenecka TM, Cameron MD. Bioactivation of the epidermal growth factor receptor inhibitor gefitinib: implications for pulmonary and hepatic toxicities. <span><span class="ref-journal">Chem Res Toxicol. </span>2009;<span class="ref-vol">22</span>(10):1736–42.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/19803472" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 19803472</span></a>]</div></dd><dt>19.</dt><dd><div class="bk_ref" id="ml302.r19">Giles RG, LN, Quick JK, Sasse MJ, Urquhart MWJ, Youssef L. Regiospecific Reduction of 5-Benzylidene-2,4-Thiazolidinediones and 4-Oxo-2-thiazolidinethiones using Lithium Borohydride in Pyridine and Tetrahydrofuran. <span><span class="ref-journal">Tetrahedron. </span>2000;<span class="ref-vol">56</span>(26):4531–4537.</span></div></dd><dt>20.</dt><dd><div class="bk_ref" id="ml302.r20">Bonapace CR, Bosso JA, Friedrich LV, White RL. Comparison of methods of interpretation of checkerboard synergy testing. <span><span class="ref-journal">Diagn Microbiol Infect Dis. </span>2002;<span class="ref-vol">44</span>(4):363–6.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/12543542" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 12543542</span></a>]</div></dd><dt>21.</dt><dd><div class="bk_ref" id="ml302.r21">Bajaksouzian S, Visalli MA, Jacobs MR, Appelbaum PC. Activities of levofloxacin, ofloxacin, and ciprofloxacin, alone and in combination with amikacin, against acinetobacters as determined by checkerboard and time-kill studies. <span><span class="ref-journal">Antimicrob Agents Chemother. </span>1997;<span class="ref-vol">41</span>(5):1073–6.</span> [<a href="/pmc/articles/PMC163853/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC163853</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/9145872" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 9145872</span></a>]</div></dd><dt>22.</dt><dd><div class="bk_ref" id="ml302.r22">Wayne. E. C. a. L. S. Institute, editor. <span class="ref-journal">M26-A: Methods for Determining Bactericidal Activity of Antimicrobial Agents; Approved Guideline.</span> National Committee on Clinical Laboratory Standards; 1999. </div></dd></dl></div><div id="bk_toc_contnr"></div></div></div>
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<div class="post-content"><div><div class="half_rhythm"><a href="/books/about/copyright/">Copyright Notice</a></div><div class="small"><span class="label">Bookshelf ID: NBK143563</span><span class="label">PMID: <a href="https://pubmed.ncbi.nlm.nih.gov/23762954" title="PubMed record of this page" ref="pagearea=meta&targetsite=entrez&targetcat=link&targettype=pubmed">23762954</a></span></div><div style="margin-top:2em" class="bk_noprnt"><a class="bk_cntns" href="/books/n/mlprobe/">Contents</a><div class="pagination bk_noprnt"><a class="active page_link prev" href="/books/n/mlprobe/ml303/" title="Previous page in this title">< Prev</a><a class="active page_link next" href="/books/n/mlprobe/ml300/" title="Next page in this title">Next ></a></div></div></div></div>
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<div xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"></div><div class="portlet"><div class="portlet_head"><div class="portlet_title"><h3><span>Views</span></h3></div><a name="Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="PDF_download" id="Shutter"></a></div><div class="portlet_content"><ul xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="simple-list"><li><a href="/books/NBK143563/?report=reader">PubReader</a></li><li><a href="/books/NBK143563/?report=printable">Print View</a></li><li><a data-jig="ncbidialog" href="#_ncbi_dlg_citbx_NBK143563" data-jigconfig="width:400,modal:true">Cite this Page</a><div id="_ncbi_dlg_citbx_NBK143563" style="display:none" title="Cite this Page"><div class="bk_tt">Spicer T, Minond D, Enogieru I, et al. ML302, a Novel Beta-lactamase (BLA) Inhibitor. 2012 Apr 16 [Updated 2014 May 13]. In: Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-. <span class="bk_cite_avail"></span></div></div></li><li><a href="/books/NBK143563/pdf/Bookshelf_NBK143563.pdf">PDF version of this page</a> (3.7M)</li></ul></div></div><div class="portlet"><div class="portlet_head"><div class="portlet_title"><h3><span>In this Page</span></h3></div><a name="Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="page-toc" id="Shutter"></a></div><div class="portlet_content"><ul xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="simple-list"><li><a href="#ml302.s1" ref="log$=inpage&link_id=inpage">Probe Structure and Characteristics</a></li><li><a href="#ml302.s2" ref="log$=inpage&link_id=inpage">Recommendations for scientific use of the probe</a></li><li><a href="#ml302.s3" ref="log$=inpage&link_id=inpage">Introduction</a></li><li><a href="#ml302.s4" ref="log$=inpage&link_id=inpage">Materials and Methods</a></li><li><a href="#ml302.s8" ref="log$=inpage&link_id=inpage">Results</a></li><li><a href="#ml302.s15" ref="log$=inpage&link_id=inpage">Discussion</a></li><li><a href="#ml302.s19" ref="log$=inpage&link_id=inpage">References</a></li></ul></div></div><div class="portlet"><div class="portlet_head"><div class="portlet_title"><h3><span>Related information</span></h3></div><a name="Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="discovery_db_links" id="Shutter"></a></div><div class="portlet_content"><ul><li class="brieflinkpopper"><a class="brieflinkpopperctrl" href="/books/?Db=pmc&DbFrom=books&Cmd=Link&LinkName=books_pmc_refs&IdsFromResult=3036020" ref="log$=recordlinks">PMC</a><div class="brieflinkpop offscreen_noflow">PubMed Central citations</div></li><li class="brieflinkpopper"><a class="brieflinkpopperctrl" href="/books/?Db=pcassay&DbFrom=books&Cmd=Link&LinkName=books_pcassay_probe&IdsFromResult=3036020" ref="log$=recordlinks">PubChem BioAssay for Chemical Probe</a><div class="brieflinkpop offscreen_noflow">PubChem BioAssay records reporting screening data for the development of the chemical probe(s) described in this book chapter</div></li><li class="brieflinkpopper"><a class="brieflinkpopperctrl" href="/books/?Db=pcsubstance&DbFrom=books&Cmd=Link&LinkName=books_pcsubstance&IdsFromResult=3036020" ref="log$=recordlinks">PubChem Substance</a><div class="brieflinkpop offscreen_noflow">Related PubChem Substances</div></li><li class="brieflinkpopper"><a class="brieflinkpopperctrl" href="/books/?Db=pubmed&DbFrom=books&Cmd=Link&LinkName=books_pubmed_refs&IdsFromResult=3036020" ref="log$=recordlinks">PubMed</a><div class="brieflinkpop offscreen_noflow">Links to PubMed</div></li></ul></div></div><div class="portlet"><div class="portlet_head"><div class="portlet_title"><h3><span>Similar articles in PubMed</span></h3></div><a name="Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="PBooksDiscovery_RA" id="Shutter"></a></div><div class="portlet_content"><ul><li class="brieflinkpopper two_line"><a class="brieflinkpopperctrl" href="/pubmed/21961119" ref="ordinalpos=1&linkpos=1&log$=relatedreviews&logdbfrom=pubmed"><span xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="invert">Review</span> HTS Assay for Discovery of Novel Metallo-Beta-lactamase (MBL) Inhibitors.</a><span class="source">[Probe Reports from the NIH Mol...]</span><div class="brieflinkpop offscreen_noflow"><span xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="invert">Review</span> HTS Assay for Discovery of Novel Metallo-Beta-lactamase (MBL) Inhibitors.<div class="brieflinkpopdesc"><em xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="author">Minond D, Saldanha SA, Spicer T, Qin L, Mercer BA, Roush WR, Hodder P. </em><em xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="cit">Probe Reports from the NIH Molecular Libraries Program. 2010</em></div></div></li><li class="brieflinkpopper two_line"><a class="brieflinkpopperctrl" href="/pubmed/26643349" ref="ordinalpos=1&linkpos=2&log$=relatedarticles&logdbfrom=pubmed">Multiyear, Multinational Survey of the Incidence and Global Distribution of Metallo-β-Lactamase-Producing Enterobacteriaceae and Pseudomonas aeruginosa.</a><span class="source">[Antimicrob Agents Chemother. 2...]</span><div class="brieflinkpop offscreen_noflow">Multiyear, Multinational Survey of the Incidence and Global Distribution of Metallo-β-Lactamase-Producing Enterobacteriaceae and Pseudomonas aeruginosa.<div class="brieflinkpopdesc"><em 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Epub 2015 Dec 7.</em></div></div></li><li class="brieflinkpopper two_line"><a class="brieflinkpopperctrl" href="/pubmed/20462725" ref="ordinalpos=1&linkpos=3&log$=relatedarticles&logdbfrom=pubmed">Metallo-beta-lactamase-producing imipenem-resistant Pseudomonas aeruginosa clinical isolates in a university teaching hospital in Malaysia: detection of IMP-7 and first identification of IMP-4, VIM-2, and VIM-11.</a><span class="source">[Diagn Microbiol Infect Dis. 2010]</span><div class="brieflinkpop offscreen_noflow">Metallo-beta-lactamase-producing imipenem-resistant Pseudomonas aeruginosa clinical isolates in a university teaching hospital in Malaysia: detection of IMP-7 and first identification of IMP-4, VIM-2, and VIM-11.<div class="brieflinkpopdesc"><em xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="author">Khosravi Y, Tee Tay S, Vadivelu J. </em><em xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="cit">Diagn Microbiol Infect Dis. 2010 Jul; 67(3):294-6. Epub 2010 May 11.</em></div></div></li><li class="brieflinkpopper two_line"><a class="brieflinkpopperctrl" href="/pubmed/23277500" ref="ordinalpos=1&linkpos=4&log$=relatedarticles&logdbfrom=pubmed">bla(IMP) and bla(VIM) mediated carbapenem resistance in Pseudomonas and Acinetobacter species in India.</a><span class="source">[J Infect Dev Ctries. 2012]</span><div class="brieflinkpop offscreen_noflow">bla(IMP) and bla(VIM) mediated carbapenem resistance in Pseudomonas and Acinetobacter species in India.<div class="brieflinkpopdesc"><em xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="author">Amudhan MS, Sekar U, Kamalanathan A, Balaraman S. </em><em xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="cit">J Infect Dev Ctries. 2012 Nov 26; 6(11):757-62. Epub 2012 Nov 26.</em></div></div></li><li class="brieflinkpopper two_line"><a class="brieflinkpopperctrl" href="/pubmed/11304992" ref="ordinalpos=1&linkpos=5&log$=relatedreviews&logdbfrom=pubmed"><span xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="invert">Review</span> [Metallo-beta-lactamase producing bacteria].</a><span class="source">[Nihon Rinsho. 2001]</span><div class="brieflinkpop offscreen_noflow"><span xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="invert">Review</span> [Metallo-beta-lactamase producing bacteria].<div class="brieflinkpopdesc"><em xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="author">Iyobe S. </em><em xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="cit">Nihon Rinsho. 2001 Apr; 59(4):701-6. </em></div></div></li></ul><a class="seemore" href="/sites/entrez?db=pubmed&cmd=link&linkname=pubmed_pubmed_reviews&uid=23762954" ref="ordinalpos=1&log$=relatedreviews_seeall&logdbfrom=pubmed">See reviews...</a><a class="seemore" href="/sites/entrez?db=pubmed&cmd=link&linkname=pubmed_pubmed&uid=23762954" ref="ordinalpos=1&log$=relatedarticles_seeall&logdbfrom=pubmed">See all...</a></div></div><div class="portlet"><div class="portlet_head"><div class="portlet_title"><h3><span>Recent Activity</span></h3></div><a name="Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="recent_activity" id="Shutter"></a></div><div class="portlet_content"><div xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" id="HTDisplay" class=""><div class="action"><a href="javascript:historyDisplayState('ClearHT')">Clear</a><a href="javascript:historyDisplayState('HTOff')" class="HTOn">Turn Off</a><a href="javascript:historyDisplayState('HTOn')" class="HTOff">Turn On</a></div><ul id="activity"><li class="ra_rcd ralinkpopper two_line"><a class="htb ralinkpopperctrl" ref="log$=activity&linkpos=1" href="/portal/utils/pageresolver.fcgi?recordid=67d66b7767c23b31e0b180dd">ML302, a Novel Beta-lactamase (BLA) Inhibitor - Probe Reports from the NIH Molec...</a><div class="ralinkpop offscreen_noflow">ML302, a Novel Beta-lactamase (BLA) Inhibitor - Probe Reports from the NIH Molecular Libraries Program<div class="brieflinkpopdesc"></div></div><div class="tertiary"></div></li><li class="ra_rcd ralinkpopper two_line"><a class="htb ralinkpopperctrl" ref="log$=activity&linkpos=2" href="/portal/utils/pageresolver.fcgi?recordid=67d66b762f30673f7bf66b41">Discovery of Small Molecule Influenza Virus NS1 Antagonist - Probe Reports from ...</a><div class="ralinkpop offscreen_noflow">Discovery of Small Molecule Influenza Virus NS1 Antagonist - Probe Reports from the NIH Molecular Libraries Program<div class="brieflinkpopdesc"></div></div><div class="tertiary"></div></li><li class="ra_rcd ralinkpopper two_line"><a class="htb ralinkpopperctrl" ref="log$=activity&linkpos=3" href="/portal/utils/pageresolver.fcgi?recordid=67d66b7567c23b31e0b17954">A 2nd Selective Inhibitor of Plasmodium falciparum Glucose-6-Phosphate Dehydroge...</a><div class="ralinkpop offscreen_noflow">A 2nd Selective Inhibitor of Plasmodium falciparum Glucose-6-Phosphate Dehydrogenase (PfG6PDH) - Probe 2 - Probe Reports from the NIH Molecular Libraries Program<div class="brieflinkpopdesc"></div></div><div class="tertiary"></div></li><li class="ra_rcd ralinkpopper two_line"><a class="htb ralinkpopperctrl" ref="log$=activity&linkpos=4" href="/portal/utils/pageresolver.fcgi?recordid=67d66b7467c23b31e0b176a9">Discovery of Novel General Anesthetics Using Apoferritin as a Surrogate System -...</a><div class="ralinkpop offscreen_noflow">Discovery of Novel General Anesthetics Using Apoferritin as a Surrogate System - Probe Reports from the NIH Molecular Libraries Program<div class="brieflinkpopdesc"></div></div><div class="tertiary"></div></li><li class="ra_rcd ralinkpopper two_line"><a class="htb ralinkpopperctrl" ref="log$=activity&linkpos=5" href="/portal/utils/pageresolver.fcgi?recordid=67d66b7367c23b31e0b174e0">Selective UBC 13 Inhibitors - Probe Reports from the NIH Molecular Libraries Pro...</a><div class="ralinkpop offscreen_noflow">Selective UBC 13 Inhibitors - Probe Reports from the NIH Molecular Libraries Program<div class="brieflinkpopdesc"></div></div><div class="tertiary"></div></li></ul><p class="HTOn">Your browsing activity is empty.</p><p class="HTOff">Activity recording is turned off.</p><p id="turnOn" class="HTOff"><a href="javascript:historyDisplayState('HTOn')">Turn recording back on</a></p><a class="seemore" href="/sites/myncbi/recentactivity">See more...</a></div></div></div>
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