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<script type="text/javascript" src="/corehtml/pmc/jatsreader/ptpmc_3.22/js/jr.boots.min.js"> </script><title>Optimization and characterization of a triazole urea dual inhibitor for lysophospholipase 1 (LYPLA1) and lysophospholipase 2 (LYPLA2) - Probe Reports from the NIH Molecular Libraries Program - NCBI Bookshelf</title>
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<meta name="citation_inbook_title" content="Probe Reports from the NIH Molecular Libraries Program [Internet]">
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<meta name="citation_title" content="Optimization and characterization of a triazole urea dual inhibitor for lysophospholipase 1 (LYPLA1) and lysophospholipase 2 (LYPLA2)">
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<meta name="citation_publisher" content="National Center for Biotechnology Information (US)">
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<meta name="citation_date" content="2013/03/07">
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<meta name="citation_author" content="Alexander Adibekian">
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<meta name="citation_author" content="Brent R Martin">
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<meta name="citation_author" content="Anna E Speers">
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<meta name="citation_author" content="Steven J Brown">
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<meta name="citation_author" content="Timothy Spicer">
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<meta name="citation_author" content="Virneliz Fernandez-Vega">
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<meta name="citation_author" content="Jill Ferguson">
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<meta name="citation_author" content="Benjamin F Cravatt">
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<meta name="citation_author" content="Peter Hodder">
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<meta name="citation_author" content="Hugh Rosen">
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<meta name="citation_pmid" content="23658947">
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<meta name="DC.Title" content="Optimization and characterization of a triazole urea dual inhibitor for lysophospholipase 1 (LYPLA1) and lysophospholipase 2 (LYPLA2)">
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<meta name="DC.Contributor" content="Alexander Adibekian">
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<meta name="DC.Contributor" content="Brent R Martin">
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<meta name="DC.Contributor" content="Anna E Speers">
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<meta name="DC.Contributor" content="Steven J Brown">
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<meta name="DC.Contributor" content="Timothy Spicer">
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<meta name="DC.Contributor" content="Virneliz Fernandez-Vega">
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<meta name="DC.Contributor" content="Jill Ferguson">
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<meta name="DC.Contributor" content="Benjamin F Cravatt">
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<meta name="DC.Contributor" content="Peter Hodder">
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<meta name="DC.Contributor" content="Hugh Rosen">
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<meta name="DC.Date" content="2013/03/07">
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<meta name="description" content="Protein palmitoylation is an essential post-translational modification necessary for trafficking and localization of regulatory proteins that play key roles in cell growth and signaling. Multiple oncogenes, including HRAS and SRC, require palmitoylation for malignant transformation. We [1] and others [2] have previously identified lysophospholipase 1 (LYPLA1) as a candidate protein palmitoyl thioesterase responsible for HRAS depalmitoylation in mammalian cells. Seeking chemical tools to investigate biochemical pathway involvement and potential roles in cancer pathogenesis, we conducted a fluorescence polarization-based competitive activity-based protein profiling (FluoPol ABPP) [3] high throughput screening (HTS) campaign to identify inhibitors of LYPLA1 and the structurally related LYPLA2. HTS identified a micromolar triazole urea inhibitor, which we successfully optimized via several rounds of structure activity relationship (SAR)-by-synthesis to produce ML211 (SID 99445338), a low nanomolar dual inhibitor of LYPLA1 and LYPLA2. The reported probe operates by a covalent mechanism of action and is active both in vitro and in situ. Out of more than 20 serine hydrolases (SHs) profiled by gel-based competitive ABPP, ML211 is observed to have one anti-target, alpha/beta hydrolase domain-containing protein 11 (ABHD11). However, during our SAR campaign, we fortuitously discovered a selective ABHD11 inhibitor from among the synthetic triazole urea library compounds. This compound, ML226, is presented as an anti-probe for control studies.">
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<meta name="og:description" content="Protein palmitoylation is an essential post-translational modification necessary for trafficking and localization of regulatory proteins that play key roles in cell growth and signaling. Multiple oncogenes, including HRAS and SRC, require palmitoylation for malignant transformation. We [1] and others [2] have previously identified lysophospholipase 1 (LYPLA1) as a candidate protein palmitoyl thioesterase responsible for HRAS depalmitoylation in mammalian cells. Seeking chemical tools to investigate biochemical pathway involvement and potential roles in cancer pathogenesis, we conducted a fluorescence polarization-based competitive activity-based protein profiling (FluoPol ABPP) [3] high throughput screening (HTS) campaign to identify inhibitors of LYPLA1 and the structurally related LYPLA2. HTS identified a micromolar triazole urea inhibitor, which we successfully optimized via several rounds of structure activity relationship (SAR)-by-synthesis to produce ML211 (SID 99445338), a low nanomolar dual inhibitor of LYPLA1 and LYPLA2. The reported probe operates by a covalent mechanism of action and is active both in vitro and in situ. Out of more than 20 serine hydrolases (SHs) profiled by gel-based competitive ABPP, ML211 is observed to have one anti-target, alpha/beta hydrolase domain-containing protein 11 (ABHD11). However, during our SAR campaign, we fortuitously discovered a selective ABHD11 inhibitor from among the synthetic triazole urea library compounds. This compound, ML226, is presented as an anti-probe for control studies.">
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stroke-linecap="round" style="fill:#FFF" d="m320,350a153,153 0 1,0-2,2l170,170m-91-117 110,110-26,26-110-110"></path></svg></a><a id="jr-fip-done" class="wsprkl btn" title="Dismiss find">✘</a></nav><nav id="jr-fip-info-p"><a id="jr-fip-prev" class="wsprkl btn" title="Jump to previuos match">◀</a><button id="jr-fip-matches">no matches yet</button><a id="jr-fip-next" class="wsprkl btn" title="Jump to next match">▶</a></nav></nav></div><div id="jr-epub-interstitial" class="hidden"></div><div id="jr-content"><article data-type="main"><div class="main-content lit-style" itemscope="itemscope" itemtype="http://schema.org/CreativeWork"><div class="meta-content fm-sec"><div class="fm-sec"><h1 id="_NBK133440_"><span class="title" itemprop="name">Optimization and characterization of a triazole urea dual inhibitor for lysophospholipase 1 (LYPLA1) and lysophospholipase 2 (LYPLA2)</span></h1><p class="contribs">Adibekian A, Martin BR, Speers AE, et al.</p><p class="fm-aai"><a href="#_NBK133440_pubdet_">Publication Details</a></p></div></div><div class="jig-ncbiinpagenav body-content whole_rhythm" data-jigconfig="allHeadingLevels: ['h2'],smoothScroll: false" itemprop="text"><div id="_abs_rndgid_" itemprop="description"><p>Protein palmitoylation is an essential post-translational modification necessary for trafficking and localization of regulatory proteins that play key roles in cell growth and signaling. Multiple oncogenes, including HRAS and SRC, require palmitoylation for malignant transformation. We [<a class="bibr" href="#ml211.r1" rid="ml211.r1">1</a>] and others [<a class="bibr" href="#ml211.r2" rid="ml211.r2">2</a>] have previously identified lysophospholipase 1 (LYPLA1) as a candidate protein palmitoyl thioesterase responsible for HRAS depalmitoylation in mammalian cells. Seeking chemical tools to investigate biochemical pathway involvement and potential roles in cancer pathogenesis, we conducted a fluorescence polarization-based competitive activity-based protein profiling (FluoPol ABPP) [<a class="bibr" href="#ml211.r3" rid="ml211.r3">3</a>] high throughput screening (HTS) campaign to identify inhibitors of LYPLA1 and the structurally related LYPLA2. HTS identified a micromolar triazole urea inhibitor, which we successfully optimized via several rounds of structure activity relationship (SAR)-by-synthesis to produce <a href="/pcsubstance/?term=ML211[synonym]" ref="pagearea=abstract&targetsite=entrez&targetcat=term&targettype=pubchem">ML211</a> (<a href="https://pubchem.ncbi.nlm.nih.gov/substance/99445338" ref="pagearea=abstract&targetsite=entrez&targetcat=link&targettype=pubchem">SID 99445338</a>), a low nanomolar dual inhibitor of LYPLA1 and LYPLA2. The reported probe operates by a covalent mechanism of action and is active both <i>in vitro</i> and <i>in situ</i>. Out of more than 20 serine hydrolases (SHs) profiled by gel-based competitive ABPP, <a href="/pcsubstance/?term=ML211[synonym]" ref="pagearea=abstract&targetsite=entrez&targetcat=term&targettype=pubchem">ML211</a> is observed to have one anti-target, alpha/beta hydrolase domain-containing protein 11 (ABHD11). However, during our SAR campaign, we fortuitously discovered a selective ABHD11 inhibitor from among the synthetic triazole urea library compounds. This compound, <a href="/pcsubstance/?term=ML226[synonym]" ref="pagearea=abstract&targetsite=entrez&targetcat=term&targettype=pubchem">ML226</a>, is presented as an anti-probe for control studies.</p></div><div class="h2"></div><p><b>Assigned Assay Grant #:</b> 1 R01 CA132630</p><p><b>Screening Center Name & PI:</b> The Scripps Research Institute Molecular Screening Center (SRIMSC), H Rosen</p><p><b>Chemistry Center Name & PI:</b> SRIMSC, H Rosen</p><p><b>Assay Submitter & Institution:</b> BF Cravatt, TSRI, La Jolla</p><p><b>PubChem Summary Bioassay Identifier (AID):</b>
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<a href="https://pubchem.ncbi.nlm.nih.gov/bioassay/2202" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">2202</a> (LYPLA1), <a href="https://pubchem.ncbi.nlm.nih.gov/bioassay/2203" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">2203</a> (LYPLA2)</p><div id="ml211.s1"><h2 id="_ml211_s1_">Probe Structure & Characteristics</h2><div id="ml211.fu1" class="figure"><div class="graphic"><img src="/books/NBK133440/bin/ml211fu1.jpg" alt="Image ml211fu1" /></div></div><div class="iconblock whole_rhythm clearfix ten_col table-wrap" id="figml211tu1"><a href="/books/NBK133440/table/ml211.tu1/?report=objectonly" target="object" title="Table" class="img_link icnblk_img figpopup" rid-figpopup="figml211tu1" rid-ob="figobml211tu1"><img class="small-thumb" src="/books/NBK133440/table/ml211.tu1/?report=thumb" src-large="/books/NBK133440/table/ml211.tu1/?report=previmg" alt="Image " /></a><div class="icnblk_cntnt"><h4 id="ml211.tu1"><a href="/books/NBK133440/table/ml211.tu1/?report=objectonly" target="object" rid-ob="figobml211tu1">Table</a></h4></div></div></div><div id="ml211.s2"><h2 id="_ml211_s2_">Recommendations for Scientific Use of the Probe</h2><p>Protein palmitoylation is an essential post-translational modification (PTM), and identification of enzymes responsible for the dynamic modulation of palmitoylation is paramount to understanding its patho/physiological roles. We [<a class="bibr" href="#ml211.r1" rid="ml211.r1">1</a>] and others [<a class="bibr" href="#ml211.r2" rid="ml211.r2">2</a>] have previously identified LYPLA1 as a putative protein palmitoyl thioesterase capable of regulating HRAS palmitoylation in mammalian cells. LYPLA2 is 65% identical to LYPLA1, but its potential role as a thioesterase is unknown. The probe described in this report can inhibit LYPLA1 and LYPLA2 both <i>in vitro</i> (complex proteome lysates) and <i>in situ</i> (cells in culture) at low nanomolar concentration. The probe is observed to have one anti-target, the serine hydrolase ABHD11; however, a specific inhibitor of ABHD11 is also described herein (<a href="/pcsubstance/?term=ML226[synonym]" ref="pagearea=body&targetsite=entrez&targetcat=term&targettype=pubchem">ML226</a>), and is to be used as a control for identification of ABHD11-selective phenotypes. These inhibitors are intended for use in primary research studies aimed at elucidating the patho/physiological roles of LYPLA1 and LYPLA2.</p></div><div id="ml211.s3"><h2 id="_ml211_s3_">1. Introduction</h2><p>Protein palmitoylation is an essential PTM necessary for trafficking and localization of regulatory proteins that play key roles in cell growth and signaling. Numerous proteins have been identified as targets of palmitoylation, including cytoskeletal proteins, kinases, receptors, and other proteins involved in various aspects of cellular signaling and homeostasis [<a class="bibr" href="#ml211.r4" rid="ml211.r4">4</a>]. Using a global chemo-proteomic method for the metabolic incorporation and identification of palmitoylated proteins, we were able to identify hundreds of palmitoylated proteins, revealing palmitoylation as a widespread PTM [<a class="bibr" href="#ml211.r1" rid="ml211.r1">1</a>]. Palmitoylation involves an acyl-thioester linkage to specific cysteines [<a class="bibr" href="#ml211.r5" rid="ml211.r5">5</a>–<a class="bibr" href="#ml211.r6" rid="ml211.r6">6</a>]. Given the labile properties of thioesters, palmitoylation is potentially reversible and may be regulated in a manner analogous to other PTMs (e.g., phosphorylation). As such, identification of proteins responsible for the dynamic modulation of palmitoylation is paramount to understanding its patho/physiological roles. For example, multiple oncogenes, including HRAS and SRC, require palmitoylation-mediated localization for signaling and subsequent malignant transformation [<a class="bibr" href="#ml211.r7" rid="ml211.r7">7</a>]. It has been suggested by Waldmann <i>et al.</i> that preventing depalmitoylation of RAS by inhibiting thioesterase activity may disrupt targeted distribution (e.g., to Golgi), thereby downregulating oncogenic signaling [<a class="bibr" href="#ml211.r2" rid="ml211.r2">2</a>]. This suggests that inhibitors of protein palmitoyl thioesterases may act as tumor suppressors by preventing aberrant growth signaling. More than a decade ago, the cytosolic serine hydrolase (SH) acyl-protein thioesterase 1 (APT1) was identified as an <i>in vitro</i> HRAS palmitoyl thioesterase [<a class="bibr" href="#ml211.r8" rid="ml211.r8">8</a>]. Initially classified as lysophospholipase 1 (LYPLA1) [<a class="bibr" href="#ml211.r9" rid="ml211.r9">9</a>], the enzyme has since been demonstrated to have several hundred-fold higher activity as a protein thioesterase. While the <i>in vitro</i> data [<a class="bibr" href="#ml211.r8" rid="ml211.r8">8</a>, <a class="bibr" href="#ml211.r10" rid="ml211.r10">10</a>] provided an intriguing clue to its possible role <i>in vivo</i>, much less is known about the <i>in vivo</i> thioesterase activity of LYPLA1. Upon retroviral shRNA knockdown of LYPLA1, we found that over-expressed HRAS was hyper-palmitoylated, providing evidence that the endogenous enzyme is a functional protein palmitoyl thioesterase capable of regulating over-expressed HRAS palmitoylation in mammalian cells. However, shRNA resulted in only an 80% reduction in LYPLA1 expression (unpublished). LYPLA2 (a.k.a. APT2) is 65% identical to LYPLA1, and also exhibits lysophospholipase activity <i>in vitro</i>, but its potential role as a thioesterase is unknown [<a class="bibr" href="#ml211.r11" rid="ml211.r11">11</a>]. shRNA knockdown studies of LYPLA2 revealed only partial knockdown of the enzyme, making substrate identification inconclusive (unpublished). A principle goal of post-genomic research is the determination of the molecular and cellular role of uncharacterized enzymes like LYPLA1 and LYPLA2. As such, a dual inhibitor selective for both LYPLA1 and LYPLA2 would greatly aid investigations into the biological function of these related enzymes.</p><p>Several inhibitors of LYPLA1 have been described [<a class="bibr" href="#ml211.r2" rid="ml211.r2">2</a>, <a class="bibr" href="#ml211.r12" rid="ml211.r12">12</a>–<a class="bibr" href="#ml211.r13" rid="ml211.r13">13</a>] (see <a href="#ml211.s33">section 4.1</a> for further discussion), but none of these agents have proven capable of selectively inhibiting LYPLA1 activity in cells, and no selective inhibitors of LYPLA2 have been reported to date. To comprehensively identify LYPLA1 and LYPLA2 substrates and functionally test the role of these enzymes in dynamic de-palmitoylation and tumorigenesis, development of a high affinity and selective inhibitor capable of achieving temporal and more complete control over activity is critical.</p><p>As SHs, catalytically active LYPLA1 and LYPLA2 are readily labeled by fluorescent activity-based protein profiling (ABPP) probes bearing a fluorophosphonate (FP) reactive group [<a class="bibr" href="#ml211.r14" rid="ml211.r14">14</a>]. This reactivity can be exploited for inhibitor discovery using a competitive-ABPP platform, whereby small molecule enzyme inhibition is assessed by the ability to out-compete ABPP probe labeling [<a class="bibr" href="#ml211.r15" rid="ml211.r15">15</a>]. Competitive ABPP has also been configured to operate in a high-throughput manner via fluorescence polarization readout, FluoPol-ABPP [<a class="bibr" href="#ml211.r3" rid="ml211.r3">3</a>]. In conjunction with the SRIMSC, we applied FluoPol-ABPP to LYPLA1 and LYPLA2 inhibitor discovery. Initial efforts focused on deriving a dual LYPLA1/2 inhibitor based on a triazole urea scaffold, which has also been developed into inhibitors of other SHs (e.g, see Probe Reports for <a href="/pcsubstance/?term=ML225[synonym]" ref="pagearea=body&targetsite=entrez&targetcat=term&targettype=pubchem">ML225</a>, <a href="/pcsubstance/?term=ML294[synonym]" ref="pagearea=body&targetsite=entrez&targetcat=term&targettype=pubchem">ML294</a>, and <a href="/pcsubstance/?term=ML295[synonym]" ref="pagearea=body&targetsite=entrez&targetcat=term&targettype=pubchem">ML295</a> and ref. [<a class="bibr" href="#ml211.r16" rid="ml211.r16">16</a>]. The reported compound (<a href="/pcsubstance/?term=ML211[synonym]" ref="pagearea=body&targetsite=entrez&targetcat=term&targettype=pubchem">ML211</a>) inhibits both target enzymes with high potency (IC<sub>50</sub> 17 nM vs. LYPLA1, 30 nM vs. LYPLA2), and is active <i>in situ</i>, inhibiting LYPLA1 and LYPLA2 completely at 30nM concentration in serum-containing media. <a href="/pcsubstance/?term=ML211[synonym]" ref="pagearea=body&targetsite=entrez&targetcat=term&targettype=pubchem">ML211</a> exhibits good selectivity (50-fold) among SHs, with the exception of the SH ABHD11 (IC<sub>50</sub> 10 nM), which was a common anti-target for all triazole ureas tested; however, we were able to derive a highly potent ABHD11-selective anti-probe, <a href="/pcsubstance/?term=ML226[synonym]" ref="pagearea=body&targetsite=entrez&targetcat=term&targettype=pubchem">ML226</a> (IC<sub>50</sub> 15 nM against ABHD11, IC<sub>50</sub> >10,000 nM against LYPLA1 and LYPLA2), that is designed to be used in parallel with the dual LYPLA1/2 inhibitor for identification of ABHD11-inhibition specific effects. Selective inhibitors for LYPLA1 and/or LYPLA2 with nanomolar potency and demonstrated <i>in situ</i> activity have not been described to date.</p></div><div id="ml211.s4"><h2 id="_ml211_s4_">2. Materials and Methods</h2><p>All reagents for chemical synthesis were obtained from ThermoFisher or SigmaAldrich. All other protocols are summarized below.</p><div id="ml211.s5"><h3>2.1. Assays</h3><div id="ml211.s6"><h4>Solubility</h4><p>The solubility of compounds was tested in phosphate buffered saline, pH 7.4. Compounds were inverted for 24 hours in test tubes containing 1–2 mg of compound with 1 mL of PBS. The samples were centrifuged and analyzed by HPLC (Agilent 1100 with diode-array detector). Peak area was compared to a standard of known concentration.</p></div><div id="ml211.s7"><h4>Stability</h4><p>Demonstration of stability in PBS was conducted under conditions likely to be experienced in a laboratory setting. The compound was dissolved in 1 mL of PBS at a concentration of 10 μM, unless its maximum solubility was insufficient to achieve this concentration. Low solubility compounds were tested between ten and fifty percent of their solubility limit. The solution was immediately aliquoted into seven standard polypropylene microcentrifuge tubes which were stored at ambient temperature in a block microcentrifuge tube holder. Individual tubes were frozen at −80°C at 0, 1, 2, 4, 8, 24, and 48 hours. The frozen samples were thawed in a room temperature and an equal volume of acetonitrile was added prior to determination of concentration by LC-MS/MS.</p></div><div id="ml211.s8"><h4>LC-MS/MS for stability assay</h4><p>All analytical methods were in MRM mode where the parent ion was selected in Q1 of the mass spectrometer. The parent ion was fragmented and a characteristic fragment ion was monitored in Q3. MRM mass spectroscopy methods are particularly sensitive because additional time is spent monitoring the desired ions and not sweeping a large mass range. Methods were rapidly set up using Automaton<sup>®</sup> (Applied Biosystems), where the compounds were listed with their name and mass in an Excel datasheet. Compounds were submitted in a 96-well plate to the HPLC autosampler and slowly injected without a column present. A narrow range centered on the indicated mass was scanned to detect the parent ion. The software then evaluated a few pre-selected parameters to determine conditions that maximized the signal for the parent ion. The molecule was then fragmented in the collision cell of the mass spectrometer and fragments with m/z larger than 70 but smaller than the parent mass were determined. Three separate collision energies were evaluated to fragment the parent ion and the largest three ions were selected. Each of these three fragment ions was further optimized and the best fragment was chosen. The software then inserted the optimized masses and parameters into a template method and saved it with a unique name that indicated the individual compound being optimized. Spectra for the parent ion and the fragmentation pattern were saved and could be reviewed later.</p></div><div id="ml211.s9"><h4>Determination of glutathione reactivity</h4><p>One μL of a 10 mM compound stock solution was added to 1 mL of a freshly prepared solution of 100 μM reduced glutathione. Final compound concentration was 10 μM unless solubility limited. The solution was allowed to incubate at 37°C for two hours prior to being directly analyzed for glutathione adduct formation. LC-MS/MS analysis of GSH adducts was performed on an API 4000 Q-TrapTM mass spectrometer equipped with a Turboionspray source (Applied Biosystems, Foster City, CA). Two methodologies were utilized—a negative precursor ion (PI) scan of m/z 272, corresponding to GSH fragmenting at the thioether bond, and a neutral loss scan of −129 AMU to detect GSH adducts. This triggered positive ion enhanced resolution and enhanced product ion scans [<a class="bibr" href="#ml211.r17" rid="ml211.r17">17</a>–<a class="bibr" href="#ml211.r18" rid="ml211.r18">18</a>].</p></div></div><div id="ml211.s10"><h3>Primary Assays</h3><div id="ml211.s11"><h4>Primary uHTS assay to identify LYPLA1 inhibitors (AID 2174)</h4><p><b>Assay Overview:</b> The purpose of this assay was to identify compounds that act as LYPLA1 inhibitors. This assay also served as a counterscreen for a set of previous experiments entitled, “Fluorescence polarization-based primary biochemical high throughput screening assay to identify inhibitors of Protein Phosphatase Methylesterase 1 (PME-1)” (<a href="https://pubchem.ncbi.nlm.nih.gov/bioassay/2130" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">AID 2130</a>). This competitive activity-based protein profiling (ABPP) assay uses fluorescence polarization to investigate enzyme-substrate functional interactions based on active site-directed molecular probes [<a class="bibr" href="#ml211.r3" rid="ml211.r3">3</a>, <a class="bibr" href="#ml211.r15" rid="ml211.r15">15</a>]. A fluorophosphonate-rhodamine (FP-Rh) probe, which broadly targets enzymes from the serine hydrolase family [<a class="bibr" href="#ml211.r14" rid="ml211.r14">14</a>] was used to label LYPLA1 in the presence of test compounds. The reaction was excited with linear polarized light and the intensity of the emitted light was measured as the polarization value (mP). As designed, test compounds that act as LYPLA1 inhibitors prevent LYPLA1-probe interactions, thereby increasing the proportion of free (unbound) fluorescent probe in the well, leading to low fluorescence polarization. Omission of enzyme (which gives the same result as use of a catalytically-dead enzyme) served as a positive control. Compounds were tested at a nominal concentration of 5.9 μM.</p><p><b>Protocol Summary:</b> Prior to the start of the assay, Assay Buffer (4.0 μL; 0.01% Pluronic acid, 50 mM Tris HCl pH 8.0, 150 mM NaCl, 1mM DTT) containing LYPLA1 protein (6.25 nM) was dispensed into 1536-well microtiter plates. Next, test compound (30 nL in DMSO) or DMSO alone (0.59% final concentration) was added to the appropriate wells and incubated for 30 minutes at 25 degrees Celsius. The assay was started by dispensing FP-Rh probe (1.0 μL of 375 nM in Assay Buffer) to all wells. Plates were centrifuged and, after 10 minutes of incubation at 25 degrees Celsius, fluorescence polarization was read on a Viewlux microplate reader (PerkinElmer, Turku, Finland) using a BODIPY TMR FP filter set and a BODIPY dichroic mirror (excitation = 525 nm, emission = 598 nm). Fluorescence polarization was read for 15 seconds for each polarization plane (parallel and perpendicular). The well fluorescence polarization value (mP) was obtained via the PerkinElmer Viewlux software. <b>Assay Cutoff:</b> Compounds that inhibited LYPLA1 greater than 14.15% were considered active.</p></div><div id="ml211.s12"><h4>Confirmation uHTS assay to identify LYPLA1 inhibitors (AID 2233)</h4><p><b>Assay Overview:</b> The purpose of this assay was to confirm activity of compounds identified as active in the primary uHTS screen (<a href="https://pubchem.ncbi.nlm.nih.gov/bioassay/2174" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">AID 2174</a>). In this assay, the FP-Rh probe was used to label LYPLA1 in the presence of test compounds and analyzed as described above (<a href="https://pubchem.ncbi.nlm.nih.gov/bioassay/2174" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">AID 2174</a>). Compounds were tested in triplicate at a nominal concentration of 5.9 μM.</p><p><b>Protocol Summary:</b> The assay was performed as described above (<a href="https://pubchem.ncbi.nlm.nih.gov/bioassay/2174" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">AID 2174</a>), except that compounds were tested in triplicate. <b>Assay Cutoff:</b> Compounds that inhibited LYPLA1 greater than 14.15% were considered active.</p></div><div id="ml211.s13"><h4>Primary uHTS assay to identify LYPLA2 inhibitors (AID 2177)</h4><p><b>Assay Overview:</b> The purpose of this assay was to identify compounds that act as LYPLA2 inhibitors. This assay also served as a counterscreen for a set of previous experiments entitled, “Fluorescence polarization-based primary biochemical high throughput screening assay to identify inhibitors of Protein Phosphatase Methylesterase 1 (PME-1)” (<a href="https://pubchem.ncbi.nlm.nih.gov/bioassay/2130" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">AID 2130</a>). This competitive activity-based protein profiling (ABPP) assay uses fluorescence polarization to investigate enzyme-substrate functional interactions based on active site-directed molecular probes [<a class="bibr" href="#ml211.r3" rid="ml211.r3">3</a>, <a class="bibr" href="#ml211.r15" rid="ml211.r15">15</a>]. A fluorophosphonate-rhodamine (FP-Rh) probe, which broadly targets enzymes from the serine hydrolase family [<a class="bibr" href="#ml211.r14" rid="ml211.r14">14</a>] was used to label LYPLA2 in the presence of test compounds. The reaction was excited with linear polarized light and the intensity of the emitted light was measured as the polarization value (mP). As designed, test compounds that act as LYPLA2 inhibitors prevent LYPLA2-probe interactions, thereby increasing the proportion of free (unbound) fluorescent probe in the well, leading to low fluorescence polarization. Omission of enzyme (which gives the same result as use of a catalytically-dead enzyme) served as a positive control. Compounds were tested at a nominal concentration of 5.9 μM.</p><p><b>Protocol Summary:</b> Prior to the start of the assay, Assay Buffer (4.0 μL; 0.01% Pluronic acid, 50 mM Tris HCl pH 8.0, 150 mM NaCl, 1mM DTT) containing LYPLA2 protein (9.38 nM) was dispensed into 1536-well microtiter plates. Next, test compound (30 nL in DMSO) or DMSO alone (0.59% final concentration) was added to the appropriate wells and incubated for 30 minutes at 25 degrees Celsius. The assay was started by dispensing FP-Rh probe (1.0 μL of 375 nM in Assay Buffer) to all wells. Plates were centrifuged and, after 10 minutes of incubation at 25 degrees Celsius, fluorescence polarization was read on a Viewlux microplate reader (PerkinElmer, Turku, Finland) using a BODIPY TMR FP filter set and a BODIPY dichroic mirror (excitation = 525 nm, emission = 598 nm). Fluorescence polarization was read for 15 seconds for each polarization plane (parallel and perpendicular). The well fluorescence polarization value (mP) was obtained via the PerkinElmer Viewlux software. <b>Assay Cutoff:</b> Compounds that inhibited LYPLA2 greater than 25.78% were considered active.</p></div><div id="ml211.s14"><h4>Confirmation uHTS assay to identify LYPLA2 inhibitors (AID 2232)</h4><p><b>Assay Overview:</b> The purpose of this assay was to confirm activity of compounds identified as active in the primary uHTS screen (<a href="https://pubchem.ncbi.nlm.nih.gov/bioassay/2177" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">AID 2177</a>). In this assay, the FP-Rh probe was used to label LYPLA2 in the presence of test compounds and analyzed as described above (<a href="https://pubchem.ncbi.nlm.nih.gov/bioassay/2177" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">AID 2177</a>). Compounds were tested in triplicate at a nominal concentration of 5.9 μM.</p><p><b>Protocol Summary:</b> The assay was performed as described above (<a href="https://pubchem.ncbi.nlm.nih.gov/bioassay/2177" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">AID 2177</a>), except that compounds were tested in triplicate. <b>Assay Cutoff:</b> Compounds that inhibited LYPLA2 greater than 25.78% were considered active.</p></div></div><div id="ml211.s15"><h3>Secondary Assays</h3><div id="ml211.s16"><h4>Inhibition of LYPLA1 and LYPLA2 by top HTS hits (AID 493105)</h4><p><b>Assay Overview:</b> The purpose of this assay was to determine whether test compounds can inhibit LYPLA1 and LYPLA2 in a complex proteomic lysate using an activity-based proteomic profiling (ABPP) assay. In this assay, a complex proteome, containing endogenous and spiked-in recombinant forms of LYPLA1 or LYPLA2, was incubated with test compound followed by reaction with a rhodamine-conjugated fluorophosphonate (FP-Rh) activity-based probe. The reaction products were separated by SDS-PAGE and visualized in-gel using a flatbed fluorescence scanner. The percentage activity remaining was determined by measuring the integrated optical density (IOD) of the bands. As designed, test compounds that act as LYPLA1 and/or LYPLA2 inhibitors prevent enzyme-probe interactions, thereby decreasing the proportion of bound fluorescent probe, giving lower fluorescence intensity in the band in the gel. Percent inhibition was calculated relative to a DMSO (no compound) control.</p><p><b>Protocol Summary:</b> To soluble (Assay 1) or membrane (Assays 2–4) proteome prepared from mouse brain (1 mg/ml in DPBS) was added either 20 nM purified recombinant human (rh) LYPLA1 (Assays 1 and 3) or 20 nM purified rhLYPLA2 (Assays 2 and 4). For each Assay, proteome was treated with 20 μM test compound (1 μL of a 50× stock in DMSO) for 30 minutes at 25 degrees Celsius (50 μL reaction volume). FP-Rh (1 μL of 50× stock in DMSO) was added to a final concentration of 2 μM. The reaction was incubated for 30 minutes at 25 degrees Celsius, quenched with 2× SDS-PAGE loading buffer, separated by SDS-PAGE and visualized by in-gel fluorescent scanning. The percentage activity remaining was determined by measuring the integrated optical density of the target bands: rhLYPLA1 (Assay 1), rhLYPLA2 (Assay 2), endogenous mouse (em) LYPLA1 (Assay 3) and emLYPLA2 (Assay 4) relative to a DMSO-only (no compound) control. <b>Assay Cutoff:</b> Compounds with ≥30% inhibition of target band in each assay were considered active.</p></div><div id="ml211.s17"><h4>Triazole urea library potency and selectivity analysis (AID 493111)</h4><p><b>Assay Overview:</b> The purpose of this assay was to determine whether powder samples of test compounds could inhibit LYPLA1 and LYPLA2 in a complex proteomic lysate and to estimate compound selectivity in an activity-based proteomic profiling (ABPP) assay. In this assay, a complex proteome was incubated with test compound followed by reaction with a rhodamine-conjugated fluorophosphonate (FP-Rh) activity-based probe. The reaction products were separated by SDS-PAGE and visualized in-gel using a flatbed fluorescence scanner. The percentage activity remaining was determined by measuring the integrated optical density (IOD) of the bands. As designed, test compounds that act as LYPLA1 and/or LYPLA2 inhibitors prevent enzyme-probe interactions, thereby decreasing the proportion of bound fluorescent probe, giving lower fluorescence intensity in the band in the gel. Percent inhibition were calculated relative to a DMSO (no compound) control.</p><p><b>Protocol Summary:</b> Soluble proteome (1 mg/ml in DPBS) of BW5147-derived murine T-cells was treated with 30 nM, 200 nM, or 1.5 μM test compound (1 μL of a 50× stock in DMSO). Test compounds were incubated for 30 minutes at 25 degrees Celsius (50 μL reaction volume). FP-Rh (1 μL of 50× stock in DMSO) was added to a final concentration of 2 μM. The reaction was incubated for 30 minutes at 25 degrees Celsius, quenched with 2× SDS-PAGE loading buffer, separated by SDS-PAGE and visualized by in-gel fluorescent scanning. The percentage activity remaining was determined by measuring the integrated optical density of the target (LYPLA1 and LYPLA2) and anti-target (alpha/beta hydrolase domain-containing protein 11 [ABHD11], esterase D/formylglutathione hydrolase [ESD], and N-acylaminoacyl-peptide hydrolase [APEH]) bands relative to a DMSO-only (no compound) control. <b>Assay Cutoff:</b> Compounds with ≥50% inhibition at 200 nM were considered active. Compounds that were active for inhibition of LYPLA1 and LYPLA2 and inactive for inhibition of anti-targets ESD and APEH were considered active regardless of the ADHD11 inhibition in the overall outcome.</p></div><div id="ml211.s18"><h4>Inhibition of LYPLA1 <i>in situ</i> (AID 493108)</h4><p><b>Assay Overview:</b> The purpose of this assay was to determine whether or not powder samples of test compounds could inhibit LYPLA1, LYPLA2 and anti-target ABHD11 activity <i>in situ</i>. In this assay, cultured BW5147-derived murine T-cells were incubated with test compound. Cells were harvested and the soluble fraction was isolated and reacted with a rhodamine-conjugated fluorophosphonate (FP-Rh) activity-based probe. The reaction products were separated by SDS-PAGE and visualized in-gel using a flatbed fluorescence scanner. The percentage activity remaining was determined by measuring the integrated optical density (IOD) of the bands. As designed, test compounds that act as LYPLA1, LYPLA2 and/or ABHD11 inhibitors prevent enzyme-probe interactions, thereby decreasing the proportion of bound fluorescent probe, giving lower fluorescence intensity in the band in the gel.</p><p><b>Protocol Summary:</b> BW5147-derived murine T-cells (5 mL total volume; supplemented with 10% FCS) were treated with 30 nM test compound (5 μL of a 1000× stock in DMSO) for 2 hours at 37 degrees Celsius. Cells were harvested, washed 4 times with 10 mL DPBS, and homogenized by sonication in DPBS. The soluble fraction was isolated by centrifugation (100K × g, 45 minutes) and the protein concentration was adjusted to 1 mg/mL with DPBS. FP-Rh (1 μL of 50× stock in DMSO) was added to a final concentration of 2 μM in 50 μL total reaction volume. The reaction was incubated for 30 minutes at 25 degrees Celsius, quenched with 2× SDS-PAGE loading buffer, separated by SDS-PAGE and visualized by in-gel fluorescent scanning. The percentage activity remaining was determined by measuring the integrated optical density of the LYPLA1 band, the LYPLA2 band, and the ABHD11 band relative to a DMSO-only (no compound) control. <b>Assay Cutoff:</b> Compounds with ≥90% inhibition were considered active. Compounds active for both LYPLA1 and LYPLA2 were considered active in the overall outcome.</p></div><div id="ml211.s19"><h4>Determination of IC<sub>50</sub> values against LYPLA1 and LYPLA2 (AID 493110)</h4><p><b>Assay Overview:</b> The purpose of this assay was to determine the IC<sub>50</sub> values of powder samples of test compounds for LYPLA1 and LYPLA2 inhibition in a complex proteome. In this assay, a fluorophosphonate-conjugated rhodamine (FP-Rh) activity-based probe was used to label LYPLA1 and LYPLA2 in the presence of test compounds. The reaction products were separated by SDS-PAGE and visualized in-gel using a flatbed fluorescence scanner. The percentage activity remaining was determined by measuring the integrated optical density of the bands. As designed, test compounds that act as LYPLA1 and LYPLA2 inhibitors prevent enzyme-probe interactions, thereby decreasing the proportion of bound fluorescent probe, giving lower fluorescence intensity in the band in the gel.</p><p><b>Protocol Summary:</b> Soluble proteome (1 mg/ml in DPBS) of BW5147-derived murine T-cells was incubated with DMSO or compound for 30 minutes at 37 degrees Celsius before the addition of FP-Rh at a final concentration of 2 μM in 50 μL total reaction volume. The reaction was incubated for 30 minutes at 25 degrees Celsius, quenched with 2× SDS-PAGE loading buffer, separated by SDS-PAGE and visualized by in-gel fluorescent scanning. The percentage activity remaining was determined by measuring the integrated optical density of the bands. IC<sub>50</sub> values for inhibition of LYPLA1 and LYLA2 were determined from dose-response curves from three replicates at each inhibitor concentration (7-point 1:3 dilution series from 10 μM to 10 nM). <b>Assay Cutoff:</b> Compounds with an IC<sub>50</sub> <1 μM were considered active. Compounds active against both LYPLA1 and LYPLA2 were considered active in the overall outcome.</p></div><div id="ml211.s20"><h4>Determination of IC<sub>50</sub> values against anti-target ABHD11 (AID 493154)</h4><p><b>Assay Overview:</b> The purpose of this assay was to determine the IC<sub>50</sub> values of powder samples of test compounds for anti-target ABHD11 (alpha/beta hydrolase domain-containing protein 11) inhibition in a complex proteome. In this assay, a fluorophosphonate-conjugated rhodamine (FP-Rh) activity-based probe was used to label ABHD11 in the presence of test compounds. The reaction products were separated by SDS-PAGE and visualized in-gel using a flatbed fluorescence scanner. The percentage activity remaining was determined by measuring the integrated optical density of the bands. As designed, test compounds that act as ABHD11 inhibitors will prevent enzyme-probe interactions, thereby decreasing the proportion of bound fluorescent probe, giving lower fluorescence intensity in the band in the gel.</p><p><b>Protocol Summary:</b> Soluble proteome (1 mg/ml in DPBS) of BW5147-derived murine T-cells was incubated with DMSO or compound for 30 minutes at 37 degrees Celsius before the addition of FP-Rh at a final concentration of 2 μM in 50 μL total reaction volume. The reaction was incubated for 30 minutes at 25 degrees Celsius, quenched with 2× SDS-PAGE loading buffer, separated by SDS-PAGE and visualized by in-gel fluorescent scanning. The percentage activity remaining was determined by measuring the integrated optical density of the bands. An IC<sub>50</sub> value for inhibition of ABHD11 was determined from a dose-response curve from three replicates at each inhibitor concentration (7-point 1:3 dilution series from 10 μM to 10 nM). <b>Assay Cutoff:</b> Compounds with an IC<sub>50</sub> <1 μM were considered active.</p></div><div id="ml211.s21"><h4>Analysis of Cytotoxicity (AID 493161)</h4><p><b>Assay Overview:</b> The purpose of this assay was to determine cytotoxicity of inhibitor compounds belonging to the triazole urea scaffold. In this assay, BW5147-derived murine T-cells in either serum-free media (<b>Assay 1</b>) or media containing FCS (<b>Assay 2</b>) were incubated with test compounds, followed by determination of cell viability. The assay utilizes the WST-1 substrate which is converted into colorimetric formazan dye by the metabolic activity of viable cells. The amount of formed formazan directly correlates to the number of metabolically active cells in the culture. As designed, compounds that reduce cell viability result in decreased absorbance of the dye. Compounds were tested in quadruplicate in a 7-point 1:5 dilution series starting at a nominal test concentration of 50μM.</p><p><b>Protocol Summary:</b> This assay was started by dispensing BW5147-derived murine T-cells in RPMI media (100μL, 10×10<sup>4</sup> cells/well) into a 96-well plate. Both serum-free media (<b>Assay 1</b>) and media supplemented with fetal calf serum (FCS) (<b>Assay 2</b>) were tested. Compound (5 μL of 0–200 μM in media containing 5% DMSO) was added to each well, giving final compound concentrations of 0–50 μM. Cells were incubated for 48 hours at 37 degrees Celsius in a humidified incubator and cell viability was determined by the WST-1 assay (Roche) according to manufacturer instructions. <b>Assay Cutoff:</b> Compounds with a CC<sub>50</sub> value of < 5 μM were considered active (cytotoxic). Compounds with a CC<sub>50</sub> value ≥ 5 μM were considered inactive (non-cytotoxic). Compounds that were inactive in both assays were considered inactive in the overall outcome.</p></div><div id="ml211.s22"><h4>LC-MS/MS Analysis of Inhibitor Binding Mode (AID 493109)</h4><p><b>Assay Overview:</b> The purpose of this assay was to assess the covalent nature of an inhibitor compound belonging to the triazole urea scaffold and determine whether or not it labels the active site serine of LYPLA1. In this assay, purified enzyme was reacted with inhibitor compound, digested with trypsin, and the resulting peptides were analyzed by liquid chromatography-tandem mass spectrometry (LC-MS/MS). The resulting data were analyzed to identify sites of covalent labeling.</p><p><b>Protocol Summary:</b> Two aliquots (25 μL) of 50 μM LYPLA1 were prepared. To one aliquot was added inhibitor (0.5 μL of 10 mM in DMSO), giving a final concentration of 200 μM. To the second (control) aliquot was added DMSO (0.5 μL). Reactions were gently vortexed and incubated at room temperature for 30 minutes. To each reaction was added solid urea (50 mg), followed by freshly prepared aqueous ammonium bicarbonate (75 μL of 25 mM). The reactions were vortexed until the urea was dissolved. Final urea concentration was approximately 8 M. To each reaction was added freshly prepared TCEP (5 μL of 100 mM in water), and the reactions were incubated at 30 degrees Celsius for 30 minutes. To each reaction was then added freshly prepared IAA (10 μL of 100 mM in water), and the reactions were incubated for 30 min at room temperature in the dark. Aqueous ammonium bicarbonate (375 μL of 25 mM) was added to reduce the urea concentration to 2 M. To each reaction was added sequencing grade modified trypsin (1 μg), and reactions were incubated at 37 degrees Celsius for 12 hours. Formic acid was added to 5% (v/v) final.</p><p>An Agilent 1200 series quaternary HPLC pump and Thermo Scientific LTQ-Orbitrap mass spectrometer were used for sample analysis. A fraction (10 μL) of the protein digest for each sample was pressure-loaded onto a 100 micron fused-silica column (with a 5 micron in-house pulled tip) packed with 10 cm of Aqua C18 reversed-phase packing material. Chromatography was carried out using an increasing gradient of aqueous acetonitrile containing 0.1% formic acid over 125 minutes. Mass spectra were acquired in a data-dependent mode with dynamic exclusion enabled.</p><p>The MS/MS spectra generated for each run were searched against a human protein database concatenated to a reversed decoy database using Sequest. A static modification of +57.021 was specified cysteine, and a variable modification of +167.131 was specified for serine to account for possible probe labeling by AA64-2. The resulting peptide identifications were assembled into protein identifications using DTASelect, and filters were adjusted to maintain a false discovery rate (as determined by number of hits against the reversed database) of <1%. Any modified peptides identified in the DMSO-treated sample were discarded as spurious hits. <b>Assay Cutoff:</b> Compounds observed to covalently modify the active site serine of LYPLA1 were considered active.</p></div></div><div id="ml211.s23"><h3>2.2. Probe Chemical Characterization</h3><div id="ml211.fu2" class="figure bk_fig"><div class="graphic"><img src="/books/NBK133440/bin/ml211fu2.jpg" alt="CID 56593118, SID 99445338, ML211." /></div><h3><span class="title">CID 56593118, SID 99445338, ML211</span></h3></div><p>The probe structure was verified by <sup>1</sup>H NMR (see <a href="#ml211.s24">section 2.3</a>) and high resolution MS (<i>m/z</i> calculated for C<sub>25</sub>H<sub>30</sub>N<sub>4</sub>O<sub>2</sub> [M+H]<sup>+</sup>: 418.2369; found: 418.2382). Purity was assessed to be greater than 95% by NMR. The 2,4-regiostereochemistry was assigned by NMR by comparison with NMR shifts of triazole urea compounds of known 1,4 and 2,4 triazole substitution based on crystal structure data [<a class="bibr" href="#ml211.r16" rid="ml211.r16">16</a>]. Solubility in PBS (137 mM NaCl, 2.7 mM KCl, 10 mM sodium phosphate dibasic, 2 mM potassium phosphate monobasic, pH 7.4) at room temperature was determined by UV trace to be 6.6 μM. Stability could not be assessed using the standard LC-MS assay, as the probe was found to be unstable under ESI conditions.</p><div class="iconblock whole_rhythm clearfix ten_col table-wrap" id="figml211t1"><a href="/books/NBK133440/table/ml211.t1/?report=objectonly" target="object" title="Table 1" class="img_link icnblk_img figpopup" rid-figpopup="figml211t1" rid-ob="figobml211t1"><img class="small-thumb" src="/books/NBK133440/table/ml211.t1/?report=thumb" src-large="/books/NBK133440/table/ml211.t1/?report=previmg" alt="Table 1. Compounds submitted to the SMR collection." /></a><div class="icnblk_cntnt"><h4 id="ml211.t1"><a href="/books/NBK133440/table/ml211.t1/?report=objectonly" target="object" rid-ob="figobml211t1">Table 1</a></h4><p class="float-caption no_bottom_margin">Compounds submitted to the SMR collection. </p></div></div></div><div id="ml211.s24"><h3>2.3. Probe Preparation</h3><div id="ml211.f1" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%201.%20Synthesis%20of%20ML%20211.&p=BOOKS&id=133440_ml211f1.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK133440/bin/ml211f1.jpg" alt="Figure 1. Synthesis of ML 211." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 1</span><span class="title">Synthesis of ML 211</span></h3></div><p><i>Synthesis of 4-(tert-butyl)piperidine-1-carbonyl chloride (B):</i> 4-(<i>tert</i>-butyl)piperidine <b>A</b> (1 equiv) was dissolved in dry CH<sub>2</sub>Cl<sub>2</sub> (10 mL/mmol) and cooled to 0 ºC. Triphosgene (0.6 equiv) was added and the reaction was stirred for 10 min at 0 ºC and for further 15 min at rt. The reaction was carefully quenched by dropwise addition of sat. aq. NaHCO<sub>3</sub>, diluted with CH<sub>2</sub>Cl<sub>2</sub>, and washed with brine. The organic phase was dried over Na<sub>2</sub>SO<sub>4</sub> and the solvent was removed under reduced pressure (water bath temperature <30 ºC). The crude carbamoyl chloride <b>B</b> was used for the next step without further purification. <b><i>CAUTION</i></b><i>: Triphosgene is very toxic. This reaction should be performed in a well-ventilated fume hood. Any object that comes into contact with triphosgene should be rinsed with 10% NaOH solution.</i></p><p><i>Synthesis of diphenyl(1H-1,2,3-triazol-4-yl)methanol (D):</i> NH-1,2,3-triazole <b>D</b> was prepared following a slightly modified procedure of Fokin <i>et al.</i> [<a class="bibr" href="#ml211.r19" rid="ml211.r19">19</a>]. Mixture of 37% HCHO (10 equiv), glacial AcOH (1.5 equiv), and THF (1 mL/mmol <b>C</b>) was stirred for 15 min. Sodium azide was added (1.5 equiv), followed by 1,1-diphenyl-2-propyn-1-ol <b>C</b> (562 mg, 2.7 mmol, 1 equiv). The mixture was stirred for 10 min and sodium ascorbate (0.2 equiv) was added, followed by CuSO<sub>4</sub> solution (200 mg/mL H<sub>2</sub>O; 5 mol %). The reaction was stirred for 24 h at 60 ºC. The solvents were removed and the residue was re-dissolved in 3:1 MeOH/2N NaOH (1 mL/mmol <b>C</b>). After stirring for 24 h at rt, the solvents were azeotropically removed and the residue was purified by silica gel chromatography (15:85:1 MeOH/CH<sub>2</sub>Cl<sub>2</sub>/NEt<sub>3</sub>) to yield diphenyl(1H-1,2,3-triazol-4-yl)methanol <b>D</b> (495 mg, 2.0 mmol, 73%). <sup>1</sup>H-NMR (400 MHz, <i>d<sub>6</sub></i>-DMSO): δ = 7.82 (s, 1H), 7.54-7.27 (m, 10H). HRMS: <i>m/z</i> calculated for C<sub>15</sub>H<sub>14</sub>N<sub>3</sub>O [M+H]<sup>+</sup>: 252.1131; found: 252.1135. <b><i>CAUTION:</i></b><i>This reaction may result in the formation of hydrazoic acid and should be performed in a well-ventilated fume hood and behind a blast shield. Sodium azide should not be mixed with strong acids.</i></p><p><i>Synthesis of (4-(tert-butyl)piperidin-1-yl)(4-(hydroxydiphenylmethyl)-2H-1,2,3-triazol-2-yl)methanone (<a href="/pcsubstance/?term=ML211[synonym]" ref="pagearea=body&targetsite=entrez&targetcat=term&targettype=pubchem">ML211</a>):</i> Mixture of carbonyl chloride <b>B</b> (183 mg, 0.9 mmol, 1 equiv), NH-1,2,3-triazole <b>D</b> (271 mg, 1.08 mmol, 1.2 equiv), and 4-DMAP (cat) in 5:1 THF/NEt<sub>3</sub> (2 mL/mmol <b>B</b>) was stirred for 10 h at 60 ºC. The solvents were removed to yield the desired triazole urea <b>AA64-2</b> as a 3:1 mixture of <i>N2</i>- and <i>N1</i>-carbamoylated regioisomers. Regioisomers were easily distinguishable by <sup>1</sup>H-NMR shift of the triazole ring proton by comparison to NMRs for triazole ureas of known regiochemistry based on solved crystal structures [<a class="bibr" href="#ml211.r16" rid="ml211.r16">16</a>]. The <i>N2</i>-carbamoyl triazole was isolated by silica gel chromatography (3:1 hexanes/ethyl acetate -> ethyl acetate) to afford <a href="/pcsubstance/?term=ML211[synonym]" ref="pagearea=body&targetsite=entrez&targetcat=term&targettype=pubchem">ML211</a> (193 mg, 0.46 mmol, 51%). <sup>1</sup>H-NMR (400 MHz, CDCl<sub>3</sub>): δ = 7.58 (s, 1H), 7.38-7.23 (m, 10H), 3.71-3.38 (m, 4H), 1.29-1.12 (m, 5H), 0.88 (s, 3H), 0.86 (s, 3H), 0.85 (s, 3H), purity >95%. HRMS: <i>m/z</i> calculated for C<sub>25</sub>H<sub>30</sub>N<sub>4</sub>O<sub>2</sub> [M+H]<sup>+</sup>: 418.2369; found: 418.2382.</p></div></div><div id="ml211.s25"><h2 id="_ml211_s25_">3. Results</h2><p>IC<sub>50</sub> values of 17 nM vs. LYPLA1 and 30 nM vs. LYPLA2 were derived from gel-based
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competitive ABPP data (see <a href="#ml211.s27">Section 3.2</a>) for probe <a href="/pcsubstance/?term=ML211[synonym]" ref="pagearea=body&targetsite=entrez&targetcat=term&targettype=pubchem">ML211</a> (compound <b>1.18</b>, SAR <a class="figpopup" href="/books/NBK133440/table/ml211.t3/?report=objectonly" target="object" rid-figpopup="figml211t3" rid-ob="figobml211t3">Table 3</a>). A search of more than 20 SHs yielded data for target/anti-target selectivity, revealing one anti-target: ABHD11 (IC<sub>50</sub> of 10 nM based on gel-based competitive ABPP data). <a href="/pcsubstance/?term=ML211[synonym]" ref="pagearea=body&targetsite=entrez&targetcat=term&targettype=pubchem">ML211</a> was 50-fold or more selective for all other SHs visualized by gel-based ABPP (IC<sub>50</sub> ≥ 1.5 μM). A potent and selective inhibitor of ABHD11 (IC<sub>50</sub> 15 nM for ABHD11, IC<sub>50</sub> > 10,000 nM for LYPLA1 and LYPLA2), compound <b>1.12</b> (<a href="https://pubchem.ncbi.nlm.nih.gov/substance/99445332" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">SID 99445332</a>), (<a href="/pcsubstance/?term=ML226[synonym]" ref="pagearea=body&targetsite=entrez&targetcat=term&targettype=pubchem">ML226</a>) is provided as a control anti-probe. Both <a href="/pcsubstance/?term=ML211[synonym]" ref="pagearea=body&targetsite=entrez&targetcat=term&targettype=pubchem">ML211</a> and <a href="/pcsubstance/?term=ML226[synonym]" ref="pagearea=body&targetsite=entrez&targetcat=term&targettype=pubchem">ML226</a> were shown to be highly active <i>in situ</i> against their targets (see <a href="#ml211.s30">Section 3.5</a>).</p><div class="iconblock whole_rhythm clearfix ten_col table-wrap" id="figml211t3"><a href="/books/NBK133440/table/ml211.t3/?report=objectonly" target="object" title="Table 3" class="img_link icnblk_img figpopup" rid-figpopup="figml211t3" rid-ob="figobml211t3"><img class="small-thumb" src="/books/NBK133440/table/ml211.t3/?report=thumb" src-large="/books/NBK133440/table/ml211.t3/?report=previmg" alt="Table 3. Target SAR Analysis." /></a><div class="icnblk_cntnt"><h4 id="ml211.t3"><a href="/books/NBK133440/table/ml211.t3/?report=objectonly" target="object" rid-ob="figobml211t3">Table 3</a></h4><p class="float-caption no_bottom_margin">Target SAR Analysis. </p></div></div><div id="ml211.s26"><h3>3.1. Summary of Screening Results</h3><p>In the primary FluoPol HTS assay for LYPLA1 (<a href="https://pubchem.ncbi.nlm.nih.gov/bioassay/2174" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">AID 2174</a>), ~315K compounds were screened with the SH-specific FP-Rh probe [<a class="bibr" href="#ml211.r14" rid="ml211.r14">14</a>]. A total of 499 compounds (0.16%) were active, passing the set threshold of 14.15% LYPLA1 inhibition. For the confirmation HTS screen (<a href="https://pubchem.ncbi.nlm.nih.gov/bioassay/2233" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">AID 2233</a>), 478 active compounds were retested in triplicate, and 331 compounds (69%) were confirmed as active (<a class="figpopup" href="/books/NBK133440/figure/ml211.f2/?report=objectonly" target="object" rid-figpopup="figml211f2" rid-ob="figobml211f2">Figure 2</a>).</p><div class="iconblock whole_rhythm clearfix ten_col fig" id="figml211f2" co-legend-rid="figlgndml211f2"><a href="/books/NBK133440/figure/ml211.f2/?report=objectonly" target="object" title="Figure 2" class="img_link icnblk_img figpopup" rid-figpopup="figml211f2" rid-ob="figobml211f2"><img class="small-thumb" src="/books/NBK133440/bin/ml211f2.gif" src-large="/books/NBK133440/bin/ml211f2.jpg" alt="Figure 2. Flow chart describing HTS results." /></a><div class="icnblk_cntnt" id="figlgndml211f2"><h4 id="ml211.f2"><a href="/books/NBK133440/figure/ml211.f2/?report=objectonly" target="object" rid-ob="figobml211f2">Figure 2</a></h4><p class="float-caption no_bottom_margin">Flow chart describing HTS results. </p></div></div><p>Prior to secondary screening, the active compounds were filtered to remove compounds with at least 30% activity against previous FluoPol ABPP enzyme inhibitor screens: GSTO1 (<a href="https://pubchem.ncbi.nlm.nih.gov/bioassay/1974" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">AID 1974</a>; 48 compounds), FAM108b (<a href="https://pubchem.ncbi.nlm.nih.gov/bioassay/1947" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">AID 1947</a>, 14 compounds), and PME-1 (<a href="https://pubchem.ncbi.nlm.nih.gov/bioassay/2130" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">AID 2130</a>, 16 compounds). Additionally, 23 compounds with greater than 5% hit rate in all bioassays tested were removed, as well as the majority of compounds (30) that contained esters. Of the remaining 200 compounds, all hits with at least 50% inhibition against LYPLA1 (37 compounds) were chosen for secondary screening along with 54 additional compounds cherry-picked from the remaining hits (total compounds for secondary screening = 91). Of these 91 hits, the majority (62) also showed activity against LYPLA2 in the primary (<a href="https://pubchem.ncbi.nlm.nih.gov/bioassay/2177" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">AID 2177</a>) and/or confirmation (<a href="https://pubchem.ncbi.nlm.nih.gov/bioassay/2232" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">AID 2232</a>) FluoPol ABPP HTS assay for LYPLA2 inhibitors (activity cutoff: 25.78% inhibition).</p><p>The 91 compounds selected for secondary screening were assayed for their ability to inhibit both the recombinant human (rh) and endogenous mouse (em) isoforms of LYPLA1 and LYPLA2 by gel-based competitive ABPP in the context of a complex proteome (<a href="https://pubchem.ncbi.nlm.nih.gov/bioassay/493105" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">AID 493105</a>; See <a class="figpopup" href="/books/NBK133440/figure/ml211.f10/?report=objectonly" target="object" rid-figpopup="figml211f10" rid-ob="figobml211f10">Supplemental Figures S1</a>, <a class="figpopup" href="/books/NBK133440/figure/ml211.f11/?report=objectonly" target="object" rid-figpopup="figml211f11" rid-ob="figobml211f11">S2</a>, <a class="figpopup" href="/books/NBK133440/figure/ml211.f12/?report=objectonly" target="object" rid-figpopup="figml211f12" rid-ob="figobml211f12">S3</a> and <a class="figpopup" href="/books/NBK133440/table/ml211.t4/?report=objectonly" target="object" rid-figpopup="figml211t4" rid-ob="figobml211t4">Table S1</a> at the end of this report). Compounds with at least 30% inhibition were scored as active. In this assay, a complex proteome, containing endogenous and spiked-in recombinant forms of LYPLA1 or LYPLA2, was incubated with test compound (20 μM) followed by reaction with the FP-Rh activity-based probe. The reaction products were separated by SDS-PAGE and visualized in-gel using a flatbed fluorescence scanner. Test compounds that act as LYPLA1/LYPLA2 inhibitors prevent enzyme-probe interactions, thereby decreasing the fluorescence intensity of the protein bands. Nineteen compounds were active against rhLYPLA1, 10 compounds were active against rhLYPLA2, and 5 compounds were active against both human enzymes. Of the five compounds active against both rhLYPLA1 and rhLYPLA2, three were also active against emLYPLA1 and emLYPLA2.</p><p>The top lead (Compound <b>55</b>, <a href="https://pubchem.ncbi.nlm.nih.gov/substance/7974398" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">SID 7974398</a>; see <a class="figpopup" href="/books/NBK133440/table/ml211.t2/?report=objectonly" target="object" rid-figpopup="figml211t2" rid-ob="figobml211t2">Table 2</a>) has a triazole urea scaffold that appeared readily amenable to medchem optimization. Interestingly, the second best compound (Compound <b>19</b>, <a href="https://pubchem.ncbi.nlm.nih.gov/substance/57261525" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">SID 57261525</a>; see <a class="figpopup" href="/books/NBK133440/table/ml211.t2/?report=objectonly" target="object" rid-figpopup="figml211t2" rid-ob="figobml211t2">Table 2</a>) is an amine that bears a strikingly similar structure.</p><div class="iconblock whole_rhythm clearfix ten_col table-wrap" id="figml211t2"><a href="/books/NBK133440/table/ml211.t2/?report=objectonly" target="object" title="Table 2" class="img_link icnblk_img figpopup" rid-figpopup="figml211t2" rid-ob="figobml211t2"><img class="small-thumb" src="/books/NBK133440/table/ml211.t2/?report=thumb" src-large="/books/NBK133440/table/ml211.t2/?report=previmg" alt="Table 2. Top Inhibitors from 2ary Screen." /></a><div class="icnblk_cntnt"><h4 id="ml211.t2"><a href="/books/NBK133440/table/ml211.t2/?report=objectonly" target="object" rid-ob="figobml211t2">Table 2</a></h4><p class="float-caption no_bottom_margin">Top Inhibitors from 2ary Screen. (See supplemental information for complete results.) </p></div></div><p>Additionally, as discussed in ref. [<a class="bibr" href="#ml211.r16" rid="ml211.r16">16</a>], while previously characterizing agents that perturb endocannabinoid uptake and metabolism, we discovered that the tetrazole urea LY2183240 (<b>92</b>, <a class="figpopup" href="/books/NBK133440/figure/ml211.f3/?report=objectonly" target="object" rid-figpopup="figml211f3" rid-ob="figobml211f3">Figure 3</a>) [<a class="bibr" href="#ml211.r20" rid="ml211.r20">20</a>] was a potent inhibitor of numerous SHs [<a class="bibr" href="#ml211.r21" rid="ml211.r21">21</a>], including the endocannabinoid-degrading enzymes fatty acid amide hydrolase (FAAH), monoacylglycerol lipase (MAGL or MGLL), and α/β-hydrolase 6 (ABHD6), and have confirmed that <b>92</b> inhibits FAAH by covalent, carbamoylation of the enzyme’s serine nucleophile [<a class="bibr" href="#ml211.r21" rid="ml211.r21">21</a>]. There are a handful of other reports of N-heterocyclic ureas as SH inhibitors, including the isoxazolonyl urea <b>93</b> [<a class="bibr" href="#ml211.r22" rid="ml211.r22">22</a>], and 1,2,4-triazole urea <b>94</b> [<a class="bibr" href="#ml211.r23" rid="ml211.r23">23</a>], which are potent inhibitors of hormone-sensitive lipase (LIPE); however, selectivity profiles have not been reported. Taken together, these data indicate that the triazole urea scaffold might be tolerant to modification without complete loss of binding efficiency, and would yield a probe with good <i>in vitro</i> and <i>in situ</i> properties.</p><div class="iconblock whole_rhythm clearfix ten_col fig" id="figml211f3" co-legend-rid="figlgndml211f3"><a href="/books/NBK133440/figure/ml211.f3/?report=objectonly" target="object" title="Figure 3" class="img_link icnblk_img figpopup" rid-figpopup="figml211f3" rid-ob="figobml211f3"><img class="small-thumb" src="/books/NBK133440/bin/ml211f3.gif" src-large="/books/NBK133440/bin/ml211f3.jpg" alt="Figure 3. N-Heterocyclic Urea SH Inhibitors." /></a><div class="icnblk_cntnt" id="figlgndml211f3"><h4 id="ml211.f3"><a href="/books/NBK133440/figure/ml211.f3/?report=objectonly" target="object" rid-ob="figobml211f3">Figure 3</a></h4><p class="float-caption no_bottom_margin">N-Heterocyclic Urea SH Inhibitors. </p></div></div></div><div id="ml211.s27"><h3>3.2. Dose Response Curves for Probe</h3><p>IC<sub>50</sub> values were obtained from gel-based competitive-ABPP data (<a class="figpopup" href="/books/NBK133440/figure/ml211.f4/?report=objectonly" target="object" rid-figpopup="figml211f4" rid-ob="figobml211f4">Figure 4</a>) as described in <a href="https://pubchem.ncbi.nlm.nih.gov/bioassay/493110" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">AID 493110</a>.</p><div class="iconblock whole_rhythm clearfix ten_col fig" id="figml211f4" co-legend-rid="figlgndml211f4"><a href="/books/NBK133440/figure/ml211.f4/?report=objectonly" target="object" title="Figure 4" class="img_link icnblk_img figpopup" rid-figpopup="figml211f4" rid-ob="figobml211f4"><img class="small-thumb" src="/books/NBK133440/bin/ml211f4a.gif" src-large="/books/NBK133440/bin/ml211f4a.jpg" alt="Figure 4. IC50s Curves for Probe ML211 (Compound 1.18, SID 99445338) as determined by gel-based competitive-ABPP with FP-Rh (AID 493110) against targets LYPLA1 and LYPLA2." /></a><div class="icnblk_cntnt" id="figlgndml211f4"><h4 id="ml211.f4"><a href="/books/NBK133440/figure/ml211.f4/?report=objectonly" target="object" rid-ob="figobml211f4">Figure 4</a></h4><p class="float-caption no_bottom_margin">IC<sub>50</sub>s Curves for Probe ML211 (Compound <i>1.18</i>, SID 99445338) as determined by gel-based competitive-ABPP with FP-Rh (AID 493110) against targets LYPLA1 and LYPLA2. </p></div></div></div><div id="ml211.s28"><h3>3.3. Scaffold/Moiety Chemical Liabilities</h3><p>The probe compound was determined to covalently modify the catalytic serine (Ser114) of LYPLA1 (<a href="https://pubchem.ncbi.nlm.nih.gov/bioassay/493109" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">AID 493109</a>). The observed mass shift of the active site peptide corresponds to the adduct depicted in <a class="figpopup" href="/books/NBK133440/figure/ml211.f5/?report=objectonly" target="object" rid-figpopup="figml211f5" rid-ob="figobml211f5">Figure 5</a>, formed by serine nucleophilic attack at the carbonyl followed by loss of the triazole moiety. Given the high structural homology between LYPLA1 and LYPLA2 (65% overall sequence homology; both exhibit the SH Ser-His-Asp catalytic triad signature), it is anticipated that <a href="/pcsubstance/?term=ML211[synonym]" ref="pagearea=body&targetsite=entrez&targetcat=term&targettype=pubchem">ML211</a> modifies LYPLA2 in an analogous manner.</p><div class="iconblock whole_rhythm clearfix ten_col fig" id="figml211f5" co-legend-rid="figlgndml211f5"><a href="/books/NBK133440/figure/ml211.f5/?report=objectonly" target="object" title="Figure 5" class="img_link icnblk_img figpopup" rid-figpopup="figml211f5" rid-ob="figobml211f5"><img class="small-thumb" src="/books/NBK133440/bin/ml211f5.gif" src-large="/books/NBK133440/bin/ml211f5.jpg" alt="Figure 5. Covalent modification of LYPLA1 by Probe ML211 (Compound 1.18, SID 99445338)." /></a><div class="icnblk_cntnt" id="figlgndml211f5"><h4 id="ml211.f5"><a href="/books/NBK133440/figure/ml211.f5/?report=objectonly" target="object" rid-ob="figobml211f5">Figure 5</a></h4><p class="float-caption no_bottom_margin">Covalent modification of LYPLA1 by Probe <i>ML211</i> (Compound <i>1.18</i>, SID 99445338). Active Site Peptide: <i>R.IILGGFS<sub>114</sub>QGGALSLYTALTTQQK.L</i> </p></div></div><p>The probe compound showed some reactivity with glutathione (100 μM); however, its general proteome reactivity profile (see <a class="figpopup" href="/books/NBK133440/figure/ml211.f6/?report=objectonly" target="object" rid-figpopup="figml211f6" rid-ob="figobml211f6">Figure 6</a>, last lane panels A-C) suggests that it is not a broadly reactive compound.</p><div class="iconblock whole_rhythm clearfix ten_col fig" id="figml211f6" co-legend-rid="figlgndml211f6"><a href="/books/NBK133440/figure/ml211.f6/?report=objectonly" target="object" title="Figure 6" class="img_link icnblk_img figpopup" rid-figpopup="figml211f6" rid-ob="figobml211f6"><img class="small-thumb" src="/books/NBK133440/bin/ml211f6a.gif" src-large="/books/NBK133440/bin/ml211f6a.jpg" alt="Figure 6. Potency and Selectivity of 20 Triazole Urea Synthetic Library Compounds at three compound concentrations: 1.5 μM (A), 200 nM (B), and 30 nM (C)." /></a><div class="icnblk_cntnt" id="figlgndml211f6"><h4 id="ml211.f6"><a href="/books/NBK133440/figure/ml211.f6/?report=objectonly" target="object" rid-ob="figobml211f6">Figure 6</a></h4><p class="float-caption no_bottom_margin">Potency and Selectivity of 20 Triazole Urea Synthetic Library Compounds at three compound concentrations: 1.5 μM (<i>A</i>), 200 nM (<i>B</i>), and 30 nM (<i>C</i>). Gel-based competitive ABPP assay conducted as described in AID 493111. Control = DMSO only (no compound). <a href="/books/NBK133440/figure/ml211.f6/?report=objectonly" target="object" rid-ob="figobml211f6">(more...)</a></p></div></div><p>An irreversible probe has some distinct advantages over reversible analogs. Targets can be readily characterized by methods such as mass spectrometry and click chemistry-ABPP, required dosing is often lower, irreversible compounds are not as sensitive to pharmacokinetic parameters, and administration can induce long-lasting inhibition [<a class="bibr" href="#ml211.r24" rid="ml211.r24">24</a>]. In the case of the EGFR inhibitor PD 0169414, its irreversibility and high selectivity were credited with producing prolonged inhibition of the target, alleviating concerns over short plasma half-lives and reducing the need for high peak plasma levels, thus minimizing potential nonspecific toxic effects [<a class="bibr" href="#ml211.r25" rid="ml211.r25">25</a>].</p><p>Indeed, over a third of enzymatic drug targets are irreversibly inhibited by currently marketed drugs [<a class="bibr" href="#ml211.r26" rid="ml211.r26">26</a>]. Examples of covalent enzyme-inhibitor pairs include serine type D-Ala-D-Ala carboxypeptidase, which is covalently modified by all B-lactam antibiotics, acetylcholinesterase, whose active site serine undergoes covalent modification by pyridostigmine, prostaglandin-endoperoxide synthase, which is the target of the ubiquitously prescribed aspirin, aromatase, which is irreversibly modified by exemestane, monoamine oxidase, which is covalently modified by L-deprenyl, thymidylate synthase, which is covalently modified by floxuridine, H<sup>+</sup>/K<sup>+</sup> ATPase, which undergoes covalent modification by omeprazole, esomeprazole, and lansoprazole, and triacylglycerol lipase, whose serine nucleophile is targeted by orlistat [<a class="bibr" href="#ml211.r26" rid="ml211.r26">26</a>].</p></div><div id="ml211.s29"><h3>3.4. SAR Tables</h3><p>We re-synthesized the initial HTS hit compound <b>55</b> (<a class="figpopup" href="/books/NBK133440/table/ml211.t2/?report=objectonly" target="object" rid-figpopup="figml211t2" rid-ob="figobml211t2">Table 2</a>, <a href="https://pubchem.ncbi.nlm.nih.gov/substance/7974398" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">SID 7974398</a>) as compound <b>1.1</b> (<a class="figpopup" href="/books/NBK133440/table/ml211.t3/?report=objectonly" target="object" rid-figpopup="figml211t3" rid-ob="figobml211t3">Table 3</a>; <a href="https://pubchem.ncbi.nlm.nih.gov/substance/92709166" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">SID 92709166</a>) and synthesized an additional 19 analogs with variable structures at three positions: the substituent at 4-position of the triazole (<b>R<sub>1</sub></b>), the substituent of the piperidine ring (<b>R<sub>2</sub></b>), and the identity of the atom at the 4-position of the piperidine ring (<b>X</b>) (See <a class="figpopup" href="/books/NBK133440/table/ml211.t3/?report=objectonly" target="object" rid-figpopup="figml211t3" rid-ob="figobml211t3">Table 3</a>). Note: compounds are given a prefix of “1” to distinguish them from the numbered compound in <a class="figpopup" href="/books/NBK133440/figure/ml211.f10/?report=objectonly" target="object" rid-figpopup="figml211f10" rid-ob="figobml211f10">Supplemental Figures S1</a>–<a class="figpopup" href="/books/NBK133440/figure/ml211.f12/?report=objectonly" target="object" rid-figpopup="figml211f12" rid-ob="figobml211f12">3</a> and <a class="figpopup" href="/books/NBK133440/table/ml211.t2/?report=objectonly" target="object" rid-figpopup="figml211t2" rid-ob="figobml211t2">Table 2</a>. The synthetic compounds were subject to analysis as outlined in <a href="https://pubchem.ncbi.nlm.nih.gov/bioassay/493111" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">AID 493111</a> to determine potency and anti-target selectivity (see <a class="figpopup" href="/books/NBK133440/figure/ml211.f6/?report=objectonly" target="object" rid-figpopup="figml211f6" rid-ob="figobml211f6">Figure 6</a>). As demonstrated for other triazole urea inhibitors [<a class="bibr" href="#ml211.r16" rid="ml211.r16">16</a>], this type of gel-based competitive ABPP profiling allows for simultaneous assessment of both potency and selectivity of several dozen FP-sensitive SHs. The only observed anti-targets (indicated by disappearance of band in compound treated lane relative to the DMSO control) were ABHD11, esterase D/formylglutathione hydrolase (ESD), and N-acylaminoacyl-peptide hydrolase (APEH). ABHD11 was a common anti-target for all library compounds, with inhibition of ESD and APEH more easily tailored by structural modification (see discussion below).</p><p><i>First Round SAR (variation of R<sub>1</sub>):</i> The initial round of SAR preserved the triazole urea core and the morpholine ring of the HTS hit structure <b>1.1</b> (<a href="https://pubchem.ncbi.nlm.nih.gov/substance/92709166" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">SID 92709166</a>), varying only the substituent at <b>R<sub>1</sub></b>. Of the five new compounds synthesized (<b>1.2</b> – <b>1.6</b> in SAR <a class="figpopup" href="/books/NBK133440/table/ml211.t2/?report=objectonly" target="object" rid-figpopup="figml211t2" rid-ob="figobml211t2">Table 2</a>), only compound <b>1.6</b> demonstrated improved potency against the dual targets as judged by percent inhibition against LYPLA1 and LYPLA2. Of this class, compound <b>1.6</b> had the largest substituent at <b>R<sub>1</sub></b>, a bulky di-phenyl methanol.</p><p><i>Second Round SAR (variation of X)</i>: The second round of SAR involved conversion of the morpholine to a piperdine, with the synthesis of compounds <b>1.7</b> (analog of <b>1.2</b>) and <b>1.8</b> (analog of <b>1.6</b>). Both piperidine analogs showed a marked improvement in potency as compared to their morpholine counterparts, with greater inhibition of LYPLA1 for <b>1.7</b> and LYPLA1/LYPLA2 for <b>1.8</b>.</p><p><i>Third Round of SAR (variation of R<sub>1</sub> – second iteration)</i>: Given the successful potency improvement with of compounds <b>1.7</b> and <b>1.8</b>, the third round of SAR preserved the piperidine ring and focused on a second iteration of <b>R<sub>1</sub></b> variation, with groups similar to the di-phenyl methanol of compound <b>1.8</b> synthesized: compounds <b>1.9</b> (4-phenyoxyphenyl), <b>1.10</b> (7-methoxy naphthal), and <b>1.11</b> (phenyl methanol). However, none of these compounds were as potent as <b>1.8</b> for LYPLA1 and LYPLA2, as judged by percent inhibition, although it is worth noting that the single phenyl analog, compound <b>1.11</b>, came closest to matching the potency of <b>1.8</b>.</p><p><i>Fourth Round of SAR (variation of R<sub>2</sub>)</i>: With the di-phenyl methanol substituent as the most potent <b>R<sub>1</sub></b> derivative (compound <b>1.8</b>), attention then turned to substitution of the piperidine ring (<b>R<sub>2</sub></b>). Seven di-phenyl methanol analogs (compounds <b>1.12</b> to <b>1.18</b>) with various aliphatic or aromatic substitutions at positions 2, 3, and 4 were synthesized. The ethyl substituent at position 2 in compound <b>1.12</b> completely abolished inhibition of LYPLA1 and LYPLA2, but, interestingly, gave rise to a selective inhibitor of the anti-target ABHD11. As such, compound <b>1.12</b> was designated as an anti-probe (<a href="/pcsubstance/?term=ML226[synonym]" ref="pagearea=body&targetsite=entrez&targetcat=term&targettype=pubchem">ML226</a>). A benzyl at the 3 position (compound <b>1.13</b>) was tolerated with only a modest loss of potency. As compared to compound <b>1.8</b>, potency was improved slightly with a methyl at the 4 position (compound <b>1.14</b>) but diminished when the substituent was a methoxy (compound <b>1.15</b>). This effect was likely due to electronic, rather than steric effects, as larger benzyl (compound <b>1.16</b>) and di-phenyl methanol (compound <b>1.17</b>) moieties was tolerated, and a <i>tert</i>-butyl group (compound <b>1.18</b>, <a href="/pcsubstance/?term=ML211[synonym]" ref="pagearea=body&targetsite=entrez&targetcat=term&targettype=pubchem">ML211</a>) significantly improved potency for LYPLA1 and LYPLA2 when introduced to position 4.</p><p><i>Fifth Round of SAR (variation of R<sub>1</sub> – third iteration)</i>: Starting with the most potent analog thus far, compound <b>1.18</b>, variation at <b>R<sub>1</sub></b> was revisited holding the <i>tert</i>-butyl group at <b>R<sub>2</sub></b> constant. Two additional analogs were synthesized, compound <b>1.19</b>, with a cyclohexan(1)ol at <b>R<sub>1</sub></b>, and compound <b>1.20</b>, with a 2-propanol at <b>R<sub>1</sub></b>. However, both compounds showed reduced potency as compared to compound <b>1.18</b>.</p><p><i>Selectivity Analysis</i>: Selectivity for LYPLA1 and LYPLA2 seemed to track largely with one another, with most compounds exhibiting slightly increased potency for LYPLA1 over LYPLA2. In terms of anti-targets, with the exception of compound <b>1.20</b> (which was two to three fold less potent than compound <b>1.18</b>), all compounds inhibited the anti-target ABHD11 with equal or greater potency than LYPLA1 and LYPLA2, suggesting that elimination of ABHD11 as an anti-target would involve synthesis of a significantly larger library (future directions) or investigation of alternative scaffolds. In general, the larger groups at position <b>R<sub>2</sub></b> tended to increase selectivity for LYPLA1 and LYPLA2 relative to the anti-targets APEH and ESD.</p><p><i>Summary:</i> Both the acylating group and leaving group of urea triazole inhibitors appear to play a key role in target selectivity. The electrophile has sufficiently tempered reactivity that carbamoylation is dependent upon the initial binding interaction, which can be strongly influenced by both halves of the molecule.</p><p>As compared to the initial HTS hit with an IC<sub>50</sub> of 795 nM for LYPLA1 and 5.2 μM for LYPLA2 (compound <b>1.1</b>, <a href="https://pubchem.ncbi.nlm.nih.gov/substance/92709166" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">SID 92709166</a>), after five rounds of SAR, compound <b>1.18</b> represents an almost 50-fold improvement for LYPLA1 inhibition (IC<sub>50</sub> 17 nM) and greater than a 150-fold improvement for LYPLA2 inhibition (IC<sub>50</sub> 30 nM). Given the ubiquitous presence of the anti-target ABHD11 and the fortuitous discovery of the ABHD11-selective inhibitor <b>1.12</b>, we declared compound <b>1.18</b> as probe <a href="/pcsubstance/?term=ML211[synonym]" ref="pagearea=body&targetsite=entrez&targetcat=term&targettype=pubchem">ML211</a> and compound <b>1.12</b> as the anti-probe <a href="/pcsubstance/?term=ML226[synonym]" ref="pagearea=body&targetsite=entrez&targetcat=term&targettype=pubchem">ML226</a> for use in parallel experiments as a control for ABHD11-selective phenotypes.</p></div><div id="ml211.s30"><h3>3.5. Cellular Activity</h3><p>Probe compound <b>1.18</b> (<a href="/pcsubstance/?term=ML211[synonym]" ref="pagearea=body&targetsite=entrez&targetcat=term&targettype=pubchem">ML211</a>) and analog <b>1.20</b> are highly active against both LYPLA1 and LYPLA2 <i>in situ</i> (<a href="https://pubchem.ncbi.nlm.nih.gov/bioassay/493108" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">AID 493108</a>), completely inhibiting enzymatic activity at 30 nM compound concentration after 2 hours (media + 10% serum) as assayed by gel-based competitive ABPP (<a class="figpopup" href="/books/NBK133440/figure/ml211.f7/?report=objectonly" target="object" rid-figpopup="figml211f7" rid-ob="figobml211f7">Figure 7A</a>). In this context, both compounds also completely inhibited anti-target ABHD11. However, anti-probe <a href="/pcsubstance/?term=ML226[synonym]" ref="pagearea=body&targetsite=entrez&targetcat=term&targettype=pubchem">ML226</a> is also active <i>in situ</i> against ABHD11 under the same conditions (<a class="figpopup" href="/books/NBK133440/figure/ml211.f7/?report=objectonly" target="object" rid-figpopup="figml211f7" rid-ob="figobml211f7">Figure 7B</a>), and thus can serve as an effective control for live-cell experiments. This result indicates that compound <b>1.18</b>, anti-probe <a href="/pcsubstance/?term=ML226[synonym]" ref="pagearea=body&targetsite=entrez&targetcat=term&targettype=pubchem">ML226</a>, and analog <b>1.20</b> are free to cross cell membranes and inhibit their targets in the cytoplasm of cells.</p><div class="iconblock whole_rhythm clearfix ten_col fig" id="figml211f7" co-legend-rid="figlgndml211f7"><a href="/books/NBK133440/figure/ml211.f7/?report=objectonly" target="object" title="Figure 7" class="img_link icnblk_img figpopup" rid-figpopup="figml211f7" rid-ob="figobml211f7"><img class="small-thumb" src="/books/NBK133440/bin/ml211f7.gif" src-large="/books/NBK133440/bin/ml211f7.jpg" alt="Figure 7. In Situ inhibition of target enzymes." /></a><div class="icnblk_cntnt" id="figlgndml211f7"><h4 id="ml211.f7"><a href="/books/NBK133440/figure/ml211.f7/?report=objectonly" target="object" rid-ob="figobml211f7">Figure 7</a></h4><p class="float-caption no_bottom_margin"><i>In Situ</i> inhibition of target enzymes. <i>A.</i> Selective Inhibition of LYPLA1, LYPLA2, and ABHD11 activity by Probe ML211 (compound <i>1.18</i>, <i>AA64-2</i>, SID 99445338) and Analog <i>1.20</i> (<i>AA69-2</i>, SID 99445340). <i>B.</i> Selective inhibition of ABHD11 by Anti-Probe ML226 (compound <a href="/books/NBK133440/figure/ml211.f7/?report=objectonly" target="object" rid-ob="figobml211f7">(more...)</a></p></div></div><p>The probe <a href="/pcsubstance/?term=ML211[synonym]" ref="pagearea=body&targetsite=entrez&targetcat=term&targettype=pubchem">ML211</a> (compound <b>1.18</b>), analog <b>1.20</b>, and anti-probe <a href="/pcsubstance/?term=ML226[synonym]" ref="pagearea=body&targetsite=entrez&targetcat=term&targettype=pubchem">ML226</a> were evaluated for cell toxicity (<a href="https://pubchem.ncbi.nlm.nih.gov/bioassay/493161" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">AID 493161</a>) using both serum-free and serum-supplemented media. As shown in <a class="figpopup" href="/books/NBK133440/figure/ml211.f8/?report=objectonly" target="object" rid-figpopup="figml211f8" rid-ob="figobml211f8">Figure 8</a>, all three compounds have a CC<sub>50</sub> greater than 6 μM, which is 200-fold greater than the concentration (30 nM) necessary for complete inhibition of their respective target enzyme(s) <i>in situ</i>.</p><div class="iconblock whole_rhythm clearfix ten_col fig" id="figml211f8" co-legend-rid="figlgndml211f8"><a href="/books/NBK133440/figure/ml211.f8/?report=objectonly" target="object" title="Figure 8" class="img_link icnblk_img figpopup" rid-figpopup="figml211f8" rid-ob="figobml211f8"><img class="small-thumb" src="/books/NBK133440/bin/ml211f8.gif" src-large="/books/NBK133440/bin/ml211f8.jpg" alt="Figure 8. Cytotoxicity of probe and probe analogs in serum-free (A) and serum-supplemented (B) media." /></a><div class="icnblk_cntnt" id="figlgndml211f8"><h4 id="ml211.f8"><a href="/books/NBK133440/figure/ml211.f8/?report=objectonly" target="object" rid-ob="figobml211f8">Figure 8</a></h4><p class="float-caption no_bottom_margin">Cytotoxicity of probe and probe analogs in serum-free (<i>A</i>) and serum-supplemented (<i>B</i>) media. See AID 493161 for details. </p></div></div></div><div id="ml211.s31"><h3>3.6. Profiling Assays</h3><p>To date, the HTS hit <b>55</b> (a.k.a. compound <b>1.1</b>; CID 735660) has been tested in 504 other cell-based and non-cell based bioassays deposited in PubChem, and has shown activity in only 11 of those assays, giving a hit rate of 2.0%. This low hit rate indicates that this compound class may not be generally active. No HTS activity data is yet available for probe <a href="/pcsubstance/?term=ML211[synonym]" ref="pagearea=body&targetsite=entrez&targetcat=term&targettype=pubchem">ML211</a> (compound <b>1.18</b>) or any of the synthetic analogs.</p></div></div><div id="ml211.s32"><h2 id="_ml211_s32_">4. Discussion</h2><p>Probe <a href="/pcsubstance/?term=ML211[synonym]" ref="pagearea=body&targetsite=entrez&targetcat=term&targettype=pubchem">ML211</a> (Compound <b>1.18</b>) was identified as a highly potent and selective covalent dual inhibitor of the target enzymes LYPLA1 (IC<sub>50</sub> 17 nM, <a href="https://pubchem.ncbi.nlm.nih.gov/bioassay/493110" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">AID 493110</a>) and LYPLA2 (IC<sub>50</sub> 30 nM, <a href="https://pubchem.ncbi.nlm.nih.gov/bioassay/493110" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">AID 493110</a>) that carbamoylates the catalytic serine (<a href="#ml211.s28">section 3.3</a>). The probe was observed to have one anti-target, the SH ABHD11 (IC<sub>50</sub> 10 nM, <a href="https://pubchem.ncbi.nlm.nih.gov/bioassay/493154" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">AID 493154</a>) and at least 50-fold selectivity against all other anti-targets surveyed. The anti-probe <a href="/pcsubstance/?term=ML226[synonym]" ref="pagearea=body&targetsite=entrez&targetcat=term&targettype=pubchem">ML226</a> has an IC<sub>50</sub> of 15 nM for ABHD11 (<a href="https://pubchem.ncbi.nlm.nih.gov/bioassay/493154" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">AID 493154</a>), and greater than 100-fold selectivity against potential SH anti-targets as assessed by competitive ABPP profiling (<a href="https://pubchem.ncbi.nlm.nih.gov/bioassay/493111" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">AID 493111</a>). Due to the presence of the ABHD11 anti-target, the anti-probe <a href="/pcsubstance/?term=ML226[synonym]" ref="pagearea=body&targetsite=entrez&targetcat=term&targettype=pubchem">ML226</a> should be used in parallel experiments as a control for ABHD11-specific phenotypes. Both probe <a href="/pcsubstance/?term=ML211[synonym]" ref="pagearea=body&targetsite=entrez&targetcat=term&targettype=pubchem">ML211</a> and anti-probe <a href="/pcsubstance/?term=ML226[synonym]" ref="pagearea=body&targetsite=entrez&targetcat=term&targettype=pubchem">ML226</a> are active <i>in situ</i> (<a href="#ml211.s30">section 3.5</a>), completely inhibiting their target enzymes in serum-containing media after two hours at 30 nM concentration. <a href="/pcsubstance/?term=ML211[synonym]" ref="pagearea=body&targetsite=entrez&targetcat=term&targettype=pubchem">ML211</a> is soluble in PBS at up to 6.6 μM, 200 times its active <i>in situ</i> concentration. Though the probe does show some reactivity with glutathione, the complex proteome profiles (<a class="figpopup" href="/books/NBK133440/figure/ml211.f6/?report=objectonly" target="object" rid-figpopup="figml211f6" rid-ob="figobml211f6">Figure 6</a>) do not indicate general reactivity, and HTS analog <b>55</b> (a.k.a <b>1.1</b>; CID 735660) has low (1.3%) activity in other PubChem bioassays. Taken together, these findings suggest that it is very possible to develop potent and selective probes based on tempered electrophilic scaffolds, and that <a href="/pcsubstance/?term=ML211[synonym]" ref="pagearea=body&targetsite=entrez&targetcat=term&targettype=pubchem">ML211</a> will be a highly successful probe for biochemical investigation of LYPLA1 and LYPLA2, provided the anti-probe <a href="/pcsubstance/?term=ML226[synonym]" ref="pagearea=body&targetsite=entrez&targetcat=term&targettype=pubchem">ML226</a> is used as an appropriate control.</p><div id="ml211.s33"><h3>4.1. Comparison to Existing Art and How the New Probe is an Improvement</h3><p>Several substrate-mimetic inhibitors of LYPLA1 have been described by Waldmann <i>et al</i>. [<a class="bibr" href="#ml211.r12" rid="ml211.r12">12</a>–<a class="bibr" href="#ml211.r13" rid="ml211.r13">13</a>], but none of these agents have proven capable of inhibiting LYPLA1 activity in cells, and selectivity has not been reported. The most potent of this class of LYPLA1 inhibitors (IC<sub>50</sub> 27 nM) is shown in <a class="figpopup" href="/books/NBK133440/figure/ml211.f9/?report=objectonly" target="object" rid-figpopup="figml211f9" rid-ob="figobml211f9">Figure 9A</a>; the compound has a MW of 928 and a synthetic route of more than a dozen steps. By comparison, <a href="/pcsubstance/?term=ML211[synonym]" ref="pagearea=body&targetsite=entrez&targetcat=term&targettype=pubchem">ML211</a> has been demonstrated to inhibit LYPLA1 in live cells (<a href="#ml211.s30">section 3.5</a>), can be synthesized in three steps (<a href="#ml211.s24">section 2.3</a>), and has a MW below 500.</p><div class="iconblock whole_rhythm clearfix ten_col fig" id="figml211f9" co-legend-rid="figlgndml211f9"><a href="/books/NBK133440/figure/ml211.f9/?report=objectonly" target="object" title="Figure 9" class="img_link icnblk_img figpopup" rid-figpopup="figml211f9" rid-ob="figobml211f9"><img class="small-thumb" src="/books/NBK133440/bin/ml211f9.gif" src-large="/books/NBK133440/bin/ml211f9.jpg" alt="Figure 9. Structures of existing LYPLA1-inhibitors." /></a><div class="icnblk_cntnt" id="figlgndml211f9"><h4 id="ml211.f9"><a href="/books/NBK133440/figure/ml211.f9/?report=objectonly" target="object" rid-ob="figobml211f9">Figure 9</a></h4><p class="float-caption no_bottom_margin">Structures of existing LYPLA1-inhibitors. </p></div></div><p>More recently, a small library of beta-lactone compounds, termed palmostatins, have also been reported as LYPLA1 inhibitors [<a class="bibr" href="#ml211.r2" rid="ml211.r2">2</a>]. They have a scaffold similar to the marketed drug tetrahydrolipstatin (THL a.k.a. Orlistat<sup>®</sup>, Roche). The most potent of this class is Palmostatin B, depicted in <a class="figpopup" href="/books/NBK133440/figure/ml211.f9/?report=objectonly" target="object" rid-figpopup="figml211f9" rid-ob="figobml211f9">Figure 9B</a>. In contrast to the previous class of substrate-mimetic LYPLA1 inhibitors, the palmostatins are active against LYPLA1 <i>in situ</i> and synthesis is achieved following a more tractable route. Palmostatin B has a reported IC<sub>50</sub> of 300 nM and is active <i>in situ</i> at 1 μM concentration. By comparison, <a href="/pcsubstance/?term=ML211[synonym]" ref="pagearea=body&targetsite=entrez&targetcat=term&targettype=pubchem">ML211</a> is 17-fold more potent <i>in vitro</i> (IC<sub>50</sub> 17 nM) and active at >30-fold lower concentration (30 nM) <i>in situ</i>. Additionally, we have previously profiled THL by gel-based ABPP and found that it inhibits numerous serine hydrolases [<a class="bibr" href="#ml211.r27" rid="ml211.r27">27</a>]. We therefore expect that palmostatins will similarly suffer from a wide range of anti-targets. Thus, <a href="/pcsubstance/?term=ML211[synonym]" ref="pagearea=body&targetsite=entrez&targetcat=term&targettype=pubchem">ML211</a> represents a significant improvement with regard to potency, and potentially selectivity as well.</p><p>No selective LYPLA2 or dual LYPLA1/2 inhibitors have been reported to date. As such, <a href="/pcsubstance/?term=ML211[synonym]" ref="pagearea=body&targetsite=entrez&targetcat=term&targettype=pubchem">ML211</a> represents the first LYPLA1 and/or LYPLA2 inhibitor that has demonstrated activity in living cells at sub-micromolar concentration and the first dual LYPLA1/LYPLA2 inhibitor.</p></div><div id="ml211.s34"><h3>4.2. Mechanism of Action Studies</h3><p>As determined from LC-MS/MS analysis (<a href="https://pubchem.ncbi.nlm.nih.gov/bioassay/493109" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">AID 493109</a>), the probe is an activity-based inhibitor that covalently labels the active site serine nucleophile, Ser114, of LYPLA1 (<a href="#ml211.s28">section 3.3</a>). The observed mass shift of the active site peptide suggests that reaction occurs via serine nucleophilic attack on the carbonyl followed by loss of the triazole to carbamoylate the enzyme (<a class="figpopup" href="/books/NBK133440/figure/ml211.f5/?report=objectonly" target="object" rid-figpopup="figml211f5" rid-ob="figobml211f5">Figure 5</a>). Given the high structural homology between LYPLA1 and LYPLA2 (65% overall sequence homology; both exhibit the SH catalytic triad signature), it is anticipated that <a href="/pcsubstance/?term=ML211[synonym]" ref="pagearea=body&targetsite=entrez&targetcat=term&targettype=pubchem">ML211</a> modifies LYPLA2 in an analogous manner.</p></div><div id="ml211.s35"><h3>4.3. Planned Future Studies</h3><p>We plan to continue expanding the triazole urea library for identification of additional LYPLA1, LYPLA2, and dual LYPLA1/LYPLA2 probes with optimized selectivity. Additionally, we plan to more comprehensively establish parameters for <i>in situ</i> and <i>in vivo</i> use and explore the target specificity of <a href="/pcsubstance/?term=ML211[synonym]" ref="pagearea=body&targetsite=entrez&targetcat=term&targettype=pubchem">ML211</a> via application of alkyne analogs. For biological application, we plan to use <a href="/pcsubstance/?term=ML211[synonym]" ref="pagearea=body&targetsite=entrez&targetcat=term&targettype=pubchem">ML211</a> to investigate the link between LYPLA1, LYPLA2, palmitoylation, and cancer progression by 1) global proteomic and metabolomic profiling of cultured cancer cells treated with and without probe/anti-probe to identify potential metabolic pathway involvement, 2) global profiling of palmitoylation events differentially regulated in cancer cells treated with and without probe/anti-probe, and 3) evaluating the role of LYPLA1 and LYPLA2 in cancer pathogenesis using assays that measure proliferation, migration, and invasion <i>in situ</i>. Future studies may also extend to the nervous system, where LYPLA1 has been implicated in regulating dendritic spine morphogenesis, presumably through regulating dynamic palmitoylation of key dendritic signaling and scaffolding proteins [<a class="bibr" href="#ml211.r28" rid="ml211.r28">28</a>].</p></div></div><div id="ml211.s36"><h2 id="_ml211_s36_">5. References</h2><dl class="temp-labeled-list"><dl class="bkr_refwrap"><dt>1.</dt><dd><div class="bk_ref" id="ml211.r1">Martin BR, Cravatt BF. Large-scale profiling of protein palmitoylation in mammalian cells. <span><span class="ref-journal">Nat. Methods. </span>2009;<span class="ref-vol">6</span>(2):135–8.</span> [<a href="/pmc/articles/PMC2775068/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC2775068</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/19137006" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 19137006</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>2.</dt><dd><div class="bk_ref" id="ml211.r2">Dekker FJ, et al. Small-molecule inhibition of APT1 affects Ras localization and signaling. <span><span class="ref-journal">Nat. Chem. Biol. </span>2010;<span class="ref-vol">6</span>(6):449–56.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/20418879" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 20418879</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>3.</dt><dd><div class="bk_ref" id="ml211.r3">Bachovchin DA, et al. Identification of selective inhibitors of uncharacterized enzymes by high-throughput screening with fluorescent activity-based probes. <span><span class="ref-journal">Nat. Biotechnol. </span>2009;<span class="ref-vol">27</span>(4):387–94.</span> [<a href="/pmc/articles/PMC2709489/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC2709489</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/19329999" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 19329999</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>4.</dt><dd><div class="bk_ref" id="ml211.r4">Smotrys JE, Linder ME. Palmitoylation of intracellular signaling proteins: regulation and function. <span><span class="ref-journal">Annu. Rev. Biochem. </span>2004;<span class="ref-vol">73</span>:559–87.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/15189153" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 15189153</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>5.</dt><dd><div class="bk_ref" id="ml211.r5">Magee AI, et al. Release of fatty acids from virus glycoproteins by hydroxylamine. <span><span class="ref-journal">Biochim. Biophys. Acta. </span>1984;<span class="ref-vol">798</span>(2):156–66.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/6324873" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 6324873</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>6.</dt><dd><div class="bk_ref" id="ml211.r6">Rose JK, Adams GA, Gallione CJ. The presence of cysteine in the cytoplasmic domain of the vesicular stomatitis virus glycoprotein is required for palmitate addition. <span><span class="ref-journal">Proc. Natl. Acad. Sci. U. S. A. </span>1984;<span class="ref-vol">81</span>(7):2050–4.</span> [<a href="/pmc/articles/PMC345434/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC345434</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/6326102" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 6326102</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>7.</dt><dd><div class="bk_ref" id="ml211.r7">Willumsen BM, et al. Novel determinants of H-Ras plasma membrane localization and transformation. <span><span class="ref-journal">Oncogene. </span>1996;<span class="ref-vol">13</span>(9):1901–9.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/8934536" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 8934536</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>8.</dt><dd><div class="bk_ref" id="ml211.r8">Duncan JA, Gilman AG. A cytoplasmic acyl-protein thioesterase that removes palmitate from G protein alpha subunits and p21(RAS). <span><span class="ref-journal">J. Biol. Chem. </span>1998;<span class="ref-vol">273</span>(25):15830–7.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/9624183" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 9624183</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>9.</dt><dd><div class="bk_ref" id="ml211.r9">Sugimoto H, Hayashi H, Yamashita S. Purification, cDNA cloning, and regulation of lysophospholipase from rat liver. <span><span class="ref-journal">J. Biol. Chem. </span>1996;<span class="ref-vol">271</span>(13):7705–11.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/8631810" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 8631810</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>10.</dt><dd><div class="bk_ref" id="ml211.r10">Hirano T, et al. Thioesterase activity and subcellular localization of acylprotein thioesterase 1/lysophospholipase 1. <span><span class="ref-journal">Biochim. Biophys. Acta. </span>2009;<span class="ref-vol">1791</span>(8):797–805.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/19439193" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 19439193</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>11.</dt><dd><div class="bk_ref" id="ml211.r11">Toyoda T, Sugimoto H, Yamashita S. Sequence, expression in Escherichia coli, and characterization of lysophospholipase II. <span><span class="ref-journal">Biochim. Biophys. Acta. </span>1999;<span class="ref-vol">1437</span>(2):182–93.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/10064901" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 10064901</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>12.</dt><dd><div class="bk_ref" id="ml211.r12">Biel M, et al. Synthesis and evaluation of acyl protein thioesterase 1 (APT1) inhibitors. <span><span class="ref-journal">Chemistry. </span>2006;<span class="ref-vol">12</span>(15):4121–43.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/16528788" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 16528788</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>13.</dt><dd><div class="bk_ref" id="ml211.r13">Deck P, et al. Development and biological evaluation of acyl protein thioesterase 1 (APT1) inhibitors. <span><span class="ref-journal">Angew. Chem. Int. Ed. Engl. </span>2005;<span class="ref-vol">44</span>(31):4975–80.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/16003812" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 16003812</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>14.</dt><dd><div class="bk_ref" id="ml211.r14">Jessani N, et al. Enzyme activity profiles of the secreted and membrane proteome that depict cancer cell invasiveness. <span><span class="ref-journal">Proc. Natl. Acad. Sci. U. S. A. </span>2002;<span class="ref-vol">99</span>(16):10335–40.</span> [<a href="/pmc/articles/PMC124915/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC124915</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/12149457" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 12149457</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>15.</dt><dd><div class="bk_ref" id="ml211.r15">Leung D, et al. Discovering potent and selective reversible inhibitors of enzymes in complex proteomes. <span><span class="ref-journal">Nat. Biotechnol. </span>2003;<span class="ref-vol">21</span>(6):687–91.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/12740587" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 12740587</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>16.</dt><dd><div class="bk_ref" id="ml211.r16">Adibekian A, et al. Click-generated triazole ureas as ultrapotent in vivo-active serine hydrolase inhibitors. <span><span class="ref-journal">Nat. Chem. Biol. </span>2011;<span class="ref-vol">7</span>(7):469–78.</span> [<a href="/pmc/articles/PMC3118922/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC3118922</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/21572424" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 21572424</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>17.</dt><dd><div class="bk_ref" id="ml211.r17">Li X, et al. Characterization of dasatinib and its structural analogs as CYP3A4 mechanism-based inactivators and the proposed bioactivation pathways. <span><span class="ref-journal">Drug Metab. Dispos. </span>2009;<span class="ref-vol">37</span>(6):1242–50.</span> [<a href="/pmc/articles/PMC3202349/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC3202349</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/19282395" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 19282395</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>18.</dt><dd><div class="bk_ref" id="ml211.r18">Li X, Kamenecka TM, Cameron MD. Bioactivation of the epidermal growth factor receptor inhibitor gefitinib: implications for pulmonary and hepatic toxicities. <span><span class="ref-journal">Chem. Res. Toxicol. </span>2009;<span class="ref-vol">22</span>(10):1736–42.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/19803472" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 19803472</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>19.</dt><dd><div class="bk_ref" id="ml211.r19">Kalisiak J, Sharpless KB, Fokin VV. Efficient synthesis of 2-substituted-1,2,3-triazoles. <span><span class="ref-journal">Org. Lett. </span>2008;<span class="ref-vol">10</span>(15):3171–4.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/18597477" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 18597477</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>20.</dt><dd><div class="bk_ref" id="ml211.r20">Moore SA, et al. Identification of a high-affinity binding site involved in the transport of endocannabinoids. <span><span class="ref-journal">Proc. Natl. Acad. Sci. U. S. A. </span>2005;<span class="ref-vol">102</span>(49):17852–7.</span> [<a href="/pmc/articles/PMC1295594/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC1295594</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/16314570" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 16314570</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>21.</dt><dd><div class="bk_ref" id="ml211.r21">Alexander JP, Cravatt BF. The putative endocannabinoid transport blocker LY2183240 is a potent inhibitor of FAAH and several other brain serine hydrolases. <span><span class="ref-journal">J. Am. Chem. Soc. </span>2006;<span class="ref-vol">128</span>(30):9699–704.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/16866524" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 16866524</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>22.</dt><dd><div class="bk_ref" id="ml211.r22">Lowe DB, et al. In vitro SAR of (5-(2H)-isoxazolonyl) ureas, potent inhibitors of hormone-sensitive lipase. <span><span class="ref-journal">Bioorg. Med. Chem. Lett. </span>2004;<span class="ref-vol">14</span>(12):3155–9.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/15149665" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 15149665</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>23.</dt><dd><div class="bk_ref" id="ml211.r23">Ebdrup S, et al. Synthesis and structure-activity relationship for a novel class of potent and selective carbamoyl-triazole based inhibitors of hormone sensitive lipase. <span><span class="ref-journal">J. Med. Chem. </span>2004;<span class="ref-vol">47</span>(2):400–10.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/14711311" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 14711311</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>24.</dt><dd><div class="bk_ref" id="ml211.r24">Johnson DS, Weerapana E, Cravatt BF. Strategies for discovering and derisking covalent, irreversible enzyme inhibitors. <span><span class="ref-journal">Future Med. Chem. </span>2010;<span class="ref-vol">2</span>(6):949–964.</span> [<a href="/pmc/articles/PMC2904065/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC2904065</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/20640225" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 20640225</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>25.</dt><dd><div class="bk_ref" id="ml211.r25">Vincent PW, et al. Anticancer efficacy of the irreversible EGFr tyrosine kinase inhibitor PD 0169414 against human tumor xenografts. <span><span class="ref-journal">Cancer Chemother. Pharmacol. </span>2000;<span class="ref-vol">45</span>(3):231–8.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/10663641" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 10663641</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>26.</dt><dd><div class="bk_ref" id="ml211.r26">Robertson JG. Mechanistic basis of enzyme-targeted drugs. <span><span class="ref-journal">Biochemistry. </span>2005;<span class="ref-vol">44</span>(15):5561–71.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/15823014" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 15823014</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>27.</dt><dd><div class="bk_ref" id="ml211.r27">Hoover HS, et al. Selectivity of inhibitors of endocannabinoid biosynthesis evaluated by activity-based protein profiling. <span><span class="ref-journal">Bioorg. Med. Chem. Lett. </span>2008;<span class="ref-vol">18</span>(22):5838–41.</span> [<a href="/pmc/articles/PMC2634297/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC2634297</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/18657971" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 18657971</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>28.</dt><dd><div class="bk_ref" id="ml211.r28">Siegel G, et al. A functional screen implicates microRNA-138-dependent regulation of the depalmitoylation enzyme APT1 in dendritic spine morphogenesis. <span><span class="ref-journal">Nat. Cell Biol. </span>2009;<span class="ref-vol">11</span>(6):705–16.</span> [<a href="/pmc/articles/PMC3595613/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC3595613</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/19465924" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 19465924</span></a>]</div></dd></dl></dl></div><div id="ml211.app1"><h2 id="_ml211_app1_">Appendix</h2><p id="ml211.f10"><a href="/books/NBK133440/figure/ml211.f10/?report=objectonly" target="object" rid-ob="figobml211f10" class="figpopup">Figure S1. First Round Secondary Screening: Competitive-ABPP profiling with recombinant LYPLA1 (human) and endogenous LYPLA1 and LYPLA2 (mouse brain soluble proteome): 20 μM Test Compound</a></p><p id="ml211.f11"><a href="/books/NBK133440/figure/ml211.f11/?report=objectonly" target="object" rid-ob="figobml211f11" class="figpopup">Figure S2. Second Round Secondary Screening: Competitive-ABPP profiling with recombinant LYPLA2 (human) and endogenous LYPLA1 and LYPLA2 (mouse brain membrane proteome): 20 μM Test Compound</a></p><p id="ml211.f12"><a href="/books/NBK133440/figure/ml211.f12/?report=objectonly" target="object" rid-ob="figobml211f12" class="figpopup">Figure S3. Second Round Secondary Screening: Additional gel of competitive-ABPP profiling with select compounds for quantification of endogenous LYPLA1 (mouse brain membrane proteome)</a></p><p id="ml211.t4"><a href="/books/NBK133440/table/ml211.t4/?report=objectonly" target="object" rid-ob="figobml211t4" class="figpopup">Table S1. Compounds tested by Secondary Screening (AID 493105)</a></p></div><div style="display:none"><div style="display:none" id="figml211f10"><img alt="Image ml211f10a" src-large="/books/NBK133440/bin/ml211f10a.jpg" /></div><div style="display:none" id="figml211f11"><img alt="Image ml211f11a" src-large="/books/NBK133440/bin/ml211f11a.jpg" /></div><div style="display:none" id="figml211f12"><img alt="Image ml211f12" src-large="/books/NBK133440/bin/ml211f12.jpg" /></div></div><div id="bk_toc_contnr"></div></div></div><div class="fm-sec"><h2 id="_NBK133440_pubdet_">Publication Details</h2><h3>Author Information and Affiliations</h3><p class="contrib-group"><h4>Authors</h4><span itemprop="author">Alexander Adibekian</span>,<sup>*</sup> <span itemprop="author">Brent R Martin</span>,<sup>*</sup> <span itemprop="author">Anna E Speers</span>,<sup>*</sup> <span itemprop="author">Steven J Brown</span>,<sup>*</sup> <span itemprop="author">Timothy Spicer</span>,<sup>†</sup> <span itemprop="author">Virneliz Fernandez-Vega</span>,<sup>†</sup> <span itemprop="author">Jill Ferguson</span>,<sup>*</sup> <span itemprop="author">Benjamin F Cravatt</span>,<sup>*</sup> <span itemprop="author">Peter Hodder</span>,<sup>†</sup> and <span itemprop="author">Hugh Rosen</span><sup>*</sup><sup>,a</sup>.</p><h4>Affiliations</h4><div class="affiliation"><sup>*</sup>
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The Scripps Research Institute, La Jolla CA</div><div class="affiliation"><sup>†</sup>
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The Scripps Research Institute, Jupiter, FL</div><div class="affiliation"><sup>a</sup> Corresponding author:
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<span class="before-email-separator"></span><span class="email-label">Email: </span><a href="mailto:dev@null" data-email="ude.sppircs@nesorh" class="oemail">ude.sppircs@nesorh</a></div><h3>Publication History</h3><p class="small">Received: <span itemprop="datePublished">February 25, 2011</span>; Last Update: <span itemprop="dateModified">March 7, 2013</span>.</p><h3>Copyright</h3><div><div class="half_rhythm"><a href="/books/about/copyright/">Copyright Notice</a></div></div><h3>Publisher</h3><p>National Center for Biotechnology Information (US), Bethesda (MD)</p><h3>NLM Citation</h3><p>Adibekian A, Martin BR, Speers AE, et al. Optimization and characterization of a triazole urea dual inhibitor for lysophospholipase 1 (LYPLA1) and lysophospholipase 2 (LYPLA2) 2011 Feb 25 [Updated 2013 Mar 7]. In: Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-. <span class="bk_cite_avail"></span></p></div><div class="small-screen-prev"><a href="/books/n/mlprobe/ml212/?report=reader"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 100 100" preserveAspectRatio="none"><path d="M75,30 c-80,60 -80,0 0,60 c-30,-60 -30,0 0,-60"></path><text x="20" y="28" textLength="60" style="font-size:25px">Prev</text></svg></a></div><div class="small-screen-next"><a href="/books/n/mlprobe/ml210/?report=reader"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 100 100" preserveAspectRatio="none"><path d="M25,30c80,60 80,0 0,60 c30,-60 30,0 0,-60"></path><text x="20" y="28" textLength="60" style="font-size:25px">Next</text></svg></a></div></article><article data-type="fig" id="figobml211fu1"><div id="ml211.fu1" class="figure"><div class="graphic"><img data-src="/books/NBK133440/bin/ml211fu1.jpg" alt="Image ml211fu1" /></div></div></article><article data-type="table-wrap" id="figobml211tu1"><div id="ml211.tu1" class="table"><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK133440/table/ml211.tu1/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ml211.tu1_lrgtbl__"><table class="no_bottom_margin"><thead><tr><th id="hd_h_ml211.tu1_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">CID/ML#</th><th id="hd_h_ml211.tu1_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Target Name</th><th id="hd_h_ml211.tu1_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">IC<sub>50</sub> (nM) [SID, AID]</th><th id="hd_h_ml211.tu1_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Anti-target Name(s)</th><th id="hd_h_ml211.tu1_1_1_1_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">IC<sub>50</sub> (nM) [SID, AID]</th><th id="hd_h_ml211.tu1_1_1_1_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Fold Selective<sup>†</sup></th><th id="hd_h_ml211.tu1_1_1_1_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Secondary Assay(s) Name: IC<sub>50</sub> (nM) [SID, AID]</th></tr></thead><tbody><tr><td headers="hd_h_ml211.tu1_1_1_1_1" rowspan="2" colspan="1" style="text-align:center;vertical-align:middle;">CID 56593118/<a href="/pcsubstance/?term=ML211[synonym]" ref="pagearea=body&targetsite=entrez&targetcat=term&targettype=pubchem">ML211</a></td><td headers="hd_h_ml211.tu1_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">LYPLA1 (a.k.a. APT1)</td><td headers="hd_h_ml211.tu1_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">17 [<a href="https://pubchem.ncbi.nlm.nih.gov/substance/99445338" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">SID 99445338</a>, <a href="https://pubchem.ncbi.nlm.nih.gov/bioassay/493110" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">AID 493110</a>]</td><td headers="hd_h_ml211.tu1_1_1_1_4" rowspan="2" colspan="1" style="text-align:center;vertical-align:middle;">ABHD11 and > 20 SHs<sup>*</sup></td><td headers="hd_h_ml211.tu1_1_1_1_5" rowspan="2" colspan="1" style="text-align:center;vertical-align:middle;">10 vs. ABHD11 [<a href="https://pubchem.ncbi.nlm.nih.gov/substance/99445338" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">SID 99445338</a>, <a href="https://pubchem.ncbi.nlm.nih.gov/bioassay/493154" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">AID 493154</a>]<br /><br />> 1500 vs. all other SHs [<a href="https://pubchem.ncbi.nlm.nih.gov/substance/99445338" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">SID 99445338</a>, <a href="https://pubchem.ncbi.nlm.nih.gov/bioassay/493111" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">AID 493111</a>]<sup>**</sup></td><td headers="hd_h_ml211.tu1_1_1_1_6" rowspan="2" colspan="1" style="text-align:center;vertical-align:middle;">0 vs. ABHD11<br /><br />≥ 50 vs. all other SHs</td><td headers="hd_h_ml211.tu1_1_1_1_7" rowspan="2" colspan="1" style="text-align:left;vertical-align:middle;"><b>Inhibition Assay:</b> [<a href="https://pubchem.ncbi.nlm.nih.gov/substance/99445338" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">SID 99445338</a>, <a href="https://pubchem.ncbi.nlm.nih.gov/bioassay/493105" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">AID 493105</a>]<br /><b>Selectivity Assay:</b> [<a href="https://pubchem.ncbi.nlm.nih.gov/substance/99445338" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">SID 99445338</a>, <a href="https://pubchem.ncbi.nlm.nih.gov/bioassay/493111" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">AID 493111</a>]<br /><b><i>In Situ</i> Assay:</b> [<a href="https://pubchem.ncbi.nlm.nih.gov/substance/99445338" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">SID 99445338</a>, <a href="https://pubchem.ncbi.nlm.nih.gov/bioassay/493108" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">AID 493108</a>]<br /><b>IC<sub>50</sub> Assay:</b> 17 nM LYPLA1, 30 nM LYPLA2 [<a href="https://pubchem.ncbi.nlm.nih.gov/substance/99445338" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">SID 99445338</a>, <a href="https://pubchem.ncbi.nlm.nih.gov/bioassay/493110" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">AID 493110</a>]<br /><b>IC<sub>50</sub> anti-target Assay:</b> 10 nM ABHD11 [<a href="https://pubchem.ncbi.nlm.nih.gov/substance/99445338" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">SID 99445338</a>, <a href="https://pubchem.ncbi.nlm.nih.gov/bioassay/493154" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">AID 493154</a>]<br /><b>Cytox assay:</b> [<a href="https://pubchem.ncbi.nlm.nih.gov/substance/99445338" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">SID 99445338</a>, <a href="https://pubchem.ncbi.nlm.nih.gov/bioassay/493161" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">AID 493161</a>]<br /><b>LC-MS/MS assay:</b> [<a href="https://pubchem.ncbi.nlm.nih.gov/substance/99445338" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">SID 99445338</a>, <a href="https://pubchem.ncbi.nlm.nih.gov/bioassay/493109" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">AID 493109</a>]</td></tr><tr><td headers="hd_h_ml211.tu1_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">LYPLA2 (a.k.a. APT2)</td><td headers="hd_h_ml211.tu1_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">30 [<a href="https://pubchem.ncbi.nlm.nih.gov/substance/99445338" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">SID 99445338</a>, <a href="https://pubchem.ncbi.nlm.nih.gov/bioassay/493110" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">AID 493110</a>]</td></tr></tbody></table></div><div class="tblwrap-foot"><div><dl class="temp-labeled-list small"><dl class="bkr_refwrap"><dt>*</dt><dd><div id="ml211.tfn1"><p class="no_margin">As assessed by gel-based competitive ABPP in a soluble proteome derived from murine T cells with the serine hydrolase probe FP-Rhodamine.</p></div></dd></dl><dl class="bkr_refwrap"><dt>**</dt><dd><div id="ml211.tfn2"><p class="no_margin">IC<sub>50</sub> of the anti-target is defined as greater than the test compound concentration at which less than or equal to 50% inhibition of the anti-target is observed, which is reported in <a href="https://pubchem.ncbi.nlm.nih.gov/bioassay/493111" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">AID 493111</a>. For <a href="https://pubchem.ncbi.nlm.nih.gov/substance/99445338" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">SID 99445338</a>, no anti-targets were observed for all other serine hydrolases (SHs) besides ABHD11 at 1.5 μM, so the IC<sub>50</sub> is reported as > 1.5 μM.</p></div></dd></dl><dl class="bkr_refwrap"><dt>†</dt><dd><div id="ml211.tfn3"><p class="no_margin">Fold-selectivity was calculated as: > IC50 for anti-target/IC50 for target.</p></div></dd></dl></dl></div></div></div></article><article data-type="fig" id="figobml211fu2"><div id="ml211.fu2" class="figure bk_fig"><div class="graphic"><img data-src="/books/NBK133440/bin/ml211fu2.jpg" alt="CID 56593118, SID 99445338, ML211." /></div><h3><span class="title">CID 56593118, SID 99445338, ML211</span></h3></div></article><article data-type="table-wrap" id="figobml211t1"><div id="ml211.t1" class="table"><h3><span class="label">Table 1</span><span class="title">Compounds submitted to the SMR collection</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK133440/table/ml211.t1/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ml211.t1_lrgtbl__"><table class="no_top_margin"><tbody><tr><th id="hd_b_ml211.t1_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Designation</th><th id="hd_b_ml211.t1_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Compound Lab Name</th><th id="hd_b_ml211.t1_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">CID</th><th id="hd_b_ml211.t1_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SID</th><th id="hd_b_ml211.t1_1_1_1_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SRID</th><th id="hd_b_ml211.t1_1_1_1_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">MLS</th></tr><tr><th id="hd_b_ml211.t1_1_1_2_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Probe</th><td headers="hd_b_ml211.t1_1_1_2_1 hd_b_ml211.t1_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">AA64-2</td><td headers="hd_b_ml211.t1_1_1_2_1 hd_b_ml211.t1_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">CID 56593118</td><td headers="hd_b_ml211.t1_1_1_2_1 hd_b_ml211.t1_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/99445338" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">SID 99445338</a></td><td headers="hd_b_ml211.t1_1_1_2_1 hd_b_ml211.t1_1_1_1_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-02000000958-1</td><td headers="hd_b_ml211.t1_1_1_2_1 hd_b_ml211.t1_1_1_1_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">MLS003336859</td></tr><tr><th id="hd_b_ml211.t1_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Analog 1</th><td headers="hd_b_ml211.t1_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">AA69-2</td><td headers="hd_b_ml211.t1_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">CID 46937237</td><td headers="hd_b_ml211.t1_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/99445340" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">SID 99445340</a></td><td headers="hd_b_ml211.t1_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-02000000960-1</td><td headers="hd_b_ml211.t1_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">MLS003336860</td></tr><tr><th id="hd_b_ml211.t1_1_1_4_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Analog 2</th><td headers="hd_b_ml211.t1_1_1_4_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">AA69-1</td><td headers="hd_b_ml211.t1_1_1_4_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">CID 46937229</td><td headers="hd_b_ml211.t1_1_1_4_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/99445339" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">SID 99445339</a></td><td headers="hd_b_ml211.t1_1_1_4_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-02000000959-1</td><td headers="hd_b_ml211.t1_1_1_4_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">MLS003336861</td></tr><tr><th id="hd_b_ml211.t1_1_1_5_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Analog 3</th><td headers="hd_b_ml211.t1_1_1_5_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">AA44-1</td><td headers="hd_b_ml211.t1_1_1_5_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">CID 46937236</td><td headers="hd_b_ml211.t1_1_1_5_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/99445332" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">SID 99445332</a></td><td headers="hd_b_ml211.t1_1_1_5_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-02000000952-1</td><td headers="hd_b_ml211.t1_1_1_5_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">MLS003336862</td></tr><tr><th id="hd_b_ml211.t1_1_1_6_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Analog 4</th><td headers="hd_b_ml211.t1_1_1_6_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">AA62-2</td><td headers="hd_b_ml211.t1_1_1_6_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">CID 46937243</td><td headers="hd_b_ml211.t1_1_1_6_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/99445337" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">SID 99445337</a></td><td headers="hd_b_ml211.t1_1_1_6_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-02000000957-1</td><td headers="hd_b_ml211.t1_1_1_6_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">MLS003336863</td></tr><tr><th id="hd_b_ml211.t1_1_1_7_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Analog 5</th><td headers="hd_b_ml211.t1_1_1_7_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">AA50-1</td><td headers="hd_b_ml211.t1_1_1_7_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">CID 46937231</td><td headers="hd_b_ml211.t1_1_1_7_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/99445336" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">SID 99445336</a></td><td headers="hd_b_ml211.t1_1_1_7_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-02000000956-1</td><td headers="hd_b_ml211.t1_1_1_7_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">MLS003336864</td></tr></tbody></table></div></div></article><article data-type="fig" id="figobml211f1"><div id="ml211.f1" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%201.%20Synthesis%20of%20ML%20211.&p=BOOKS&id=133440_ml211f1.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img data-src="/books/NBK133440/bin/ml211f1.jpg" alt="Figure 1. Synthesis of ML 211." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 1</span><span class="title">Synthesis of ML 211</span></h3></div></article><article data-type="table-wrap" id="figobml211t3"><div id="ml211.t3" class="table"><h3><span class="label">Table 3</span><span class="title">Target SAR Analysis<sup>*</sup></span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK133440/table/ml211.t3/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ml211.t3_lrgtbl__"><table class="no_margin"><thead><tr><th id="hd_h_ml211.t3_1_1_1_1" colspan="5" rowspan="2" headers="hd_h_ml211.t3_1_1_1_1" style="text-align:center;vertical-align:middle;"></th><th id="hd_h_ml211.t3_1_1_1_2" colspan="4" rowspan="3" headers="hd_h_ml211.t3_1_1_1_2" style="text-align:center;vertical-align:middle;">Structure<br />
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<div class="graphic"><img src="/books/NBK133440/bin/ml211fu3.jpg" alt="Image ml211fu3.jpg" /></div></th><th id="hd_h_ml211.t3_1_1_1_3" colspan="13" rowspan="1" style="text-align:center;vertical-align:middle;">Potency and Selectivity<sup>†</sup></th></tr><tr><th headers="hd_h_ml211.t3_1_1_1_3" id="hd_h_ml211.t3_1_1_2_1" colspan="2" rowspan="1" style="text-align:center;vertical-align:middle;">IC<sub>50</sub> (nM) (<a href="https://pubchem.ncbi.nlm.nih.gov/bioassay/493110" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">AID 493110</a>)</th><th headers="hd_h_ml211.t3_1_1_1_3" id="hd_h_ml211.t3_1_1_2_2" colspan="6" rowspan="1" style="text-align:center;vertical-align:middle;">% INH at given compound conc. (<a href="https://pubchem.ncbi.nlm.nih.gov/bioassay/493111" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">AID 493111</a>)</th><th headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_3" id="hd_h_ml211.t3_1_1_2_3" colspan="3" rowspan="2" style="text-align:center;vertical-align:middle;">≥50% INH against anti-target(s)<sup>‡</sup> (<a href="https://pubchem.ncbi.nlm.nih.gov/bioassay/493111" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">AID 493111</a>)</th><th headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_4" id="hd_h_ml211.t3_1_1_2_4" colspan="2" rowspan="2" style="text-align:center;vertical-align:middle;">Fold Selectivity (<a href="https://pubchem.ncbi.nlm.nih.gov/bioassay/493111" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">AID 493111</a>)</th></tr><tr><th headers="hd_h_ml211.t3_1_1_1_1 hd_h_ml211.t3_1_1_3_1" id="hd_h_ml211.t3_1_1_3_1" rowspan="2" colspan="1" style="text-align:center;vertical-align:middle;">Entry</th><th headers="hd_h_ml211.t3_1_1_1_1 hd_h_ml211.t3_1_1_3_2" id="hd_h_ml211.t3_1_1_3_2" rowspan="2" colspan="1" style="text-align:center;vertical-align:middle;">lab name</th><th headers="hd_h_ml211.t3_1_1_1_1 hd_h_ml211.t3_1_1_3_3" id="hd_h_ml211.t3_1_1_3_3" rowspan="2" colspan="1" style="text-align:center;vertical-align:middle;">CID</th><th headers="hd_h_ml211.t3_1_1_1_1 hd_h_ml211.t3_1_1_3_4" id="hd_h_ml211.t3_1_1_3_4" rowspan="2" colspan="1" style="text-align:center;vertical-align:middle;">SID</th><th headers="hd_h_ml211.t3_1_1_1_1 hd_h_ml211.t3_1_1_3_5" id="hd_h_ml211.t3_1_1_3_5" rowspan="2" colspan="1" style="text-align:center;vertical-align:middle;">SRID</th><th headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_1 hd_h_ml211.t3_1_1_3_6" id="hd_h_ml211.t3_1_1_3_6" rowspan="2" colspan="1" style="text-align:center;vertical-align:middle;">LYPLA1</th><th headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_1 hd_h_ml211.t3_1_1_3_7" id="hd_h_ml211.t3_1_1_3_7" rowspan="2" colspan="1" style="text-align:center;vertical-align:middle;">LYPLA2</th><th headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_2" id="hd_h_ml211.t3_1_1_3_8" colspan="3" rowspan="1" style="text-align:center;vertical-align:middle;">LYPLA1</th><th headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_2" id="hd_h_ml211.t3_1_1_3_9" colspan="3" rowspan="1" style="text-align:center;vertical-align:middle;">LYPLA2</th></tr><tr><th headers="hd_h_ml211.t3_1_1_1_2" id="hd_h_ml211.t3_1_1_4_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Regioisomer</th><th headers="hd_h_ml211.t3_1_1_1_2" id="hd_h_ml211.t3_1_1_4_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">R<sub>2</sub></th><th headers="hd_h_ml211.t3_1_1_1_2" id="hd_h_ml211.t3_1_1_4_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">X</th><th headers="hd_h_ml211.t3_1_1_1_2" id="hd_h_ml211.t3_1_1_4_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">R<sub>1</sub></th><th headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_2 hd_h_ml211.t3_1_1_3_8" id="hd_h_ml211.t3_1_1_4_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">30 nM</th><th headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_2 hd_h_ml211.t3_1_1_3_8" id="hd_h_ml211.t3_1_1_4_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">200 nM</th><th headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_2 hd_h_ml211.t3_1_1_3_8" id="hd_h_ml211.t3_1_1_4_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">1.5 μM</th><th headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_2 hd_h_ml211.t3_1_1_3_9" id="hd_h_ml211.t3_1_1_4_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">30 nM</th><th headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_2 hd_h_ml211.t3_1_1_3_9" id="hd_h_ml211.t3_1_1_4_9" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">200 nM</th><th headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_2 hd_h_ml211.t3_1_1_3_9" id="hd_h_ml211.t3_1_1_4_10" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">1.5 μM</th><th headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_3" id="hd_h_ml211.t3_1_1_4_11" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">30 nM</th><th headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_3" id="hd_h_ml211.t3_1_1_4_12" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">200 nM</th><th headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_3" id="hd_h_ml211.t3_1_1_4_13" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">1.5 μM</th><th headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_4" id="hd_h_ml211.t3_1_1_4_14" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">ABHD11</th><th headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_4" id="hd_h_ml211.t3_1_1_4_15" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">all other SHs<sup>§</sup></th></tr></thead><tbody><tr><td headers="hd_h_ml211.t3_1_1_1_1 hd_h_ml211.t3_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><b>1.1</b></td><td headers="hd_h_ml211.t3_1_1_1_1 hd_h_ml211.t3_1_1_3_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">HTS hit</td><td headers="hd_h_ml211.t3_1_1_1_1 hd_h_ml211.t3_1_1_3_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">CID 735660</td><td headers="hd_h_ml211.t3_1_1_1_1 hd_h_ml211.t3_1_1_3_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/92709166" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">SID 92709166</a></td><td headers="hd_h_ml211.t3_1_1_1_1 hd_h_ml211.t3_1_1_3_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-01000625310-2</td><td headers="hd_h_ml211.t3_1_1_1_2 hd_h_ml211.t3_1_1_4_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><b>N1</b></td><td headers="hd_h_ml211.t3_1_1_1_2 hd_h_ml211.t3_1_1_4_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><b>H</b></td><td headers="hd_h_ml211.t3_1_1_1_2 hd_h_ml211.t3_1_1_4_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><b>O</b></td><td headers="hd_h_ml211.t3_1_1_1_2 hd_h_ml211.t3_1_1_4_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><b>Benzo</b><sup>**</sup></td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_1 hd_h_ml211.t3_1_1_3_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">795</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_1 hd_h_ml211.t3_1_1_3_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">5200</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_2 hd_h_ml211.t3_1_1_3_8 hd_h_ml211.t3_1_1_4_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_2 hd_h_ml211.t3_1_1_3_8 hd_h_ml211.t3_1_1_4_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_2 hd_h_ml211.t3_1_1_3_8 hd_h_ml211.t3_1_1_4_7" rowspan="1" colspan="1" style="background-color:#C4D79B;text-align:center;vertical-align:middle;">50</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_2 hd_h_ml211.t3_1_1_3_9 hd_h_ml211.t3_1_1_4_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_2 hd_h_ml211.t3_1_1_3_9 hd_h_ml211.t3_1_1_4_9" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_2 hd_h_ml211.t3_1_1_3_9 hd_h_ml211.t3_1_1_4_10" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_3 hd_h_ml211.t3_1_1_4_11" rowspan="1" colspan="1" style="background-color:#FFFF00;text-align:center;vertical-align:middle;">ABHD11</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_3 hd_h_ml211.t3_1_1_4_12" rowspan="1" colspan="1" style="background-color:#FFFF00;text-align:center;vertical-align:middle;">ABHD11</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_3 hd_h_ml211.t3_1_1_4_13" rowspan="1" colspan="1" style="background-color:#FFC000;text-align:center;vertical-align:middle;">ABHD11 ESD APEH</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_4 hd_h_ml211.t3_1_1_4_14" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_4 hd_h_ml211.t3_1_1_4_15" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0</td></tr><tr><td headers="hd_h_ml211.t3_1_1_1_1 hd_h_ml211.t3_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><b>1.2</b></td><td headers="hd_h_ml211.t3_1_1_1_1 hd_h_ml211.t3_1_1_3_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">AA26-5</td><td headers="hd_h_ml211.t3_1_1_1_1 hd_h_ml211.t3_1_1_3_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">CID 46829228</td><td headers="hd_h_ml211.t3_1_1_1_1 hd_h_ml211.t3_1_1_3_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/99205814" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">SID 99205814</a></td><td headers="hd_h_ml211.t3_1_1_1_1 hd_h_ml211.t3_1_1_3_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-02000000403-1</td><td headers="hd_h_ml211.t3_1_1_1_2 hd_h_ml211.t3_1_1_4_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><b>N1</b></td><td headers="hd_h_ml211.t3_1_1_1_2 hd_h_ml211.t3_1_1_4_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><b>H</b></td><td headers="hd_h_ml211.t3_1_1_1_2 hd_h_ml211.t3_1_1_4_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><b>O</b></td><td headers="hd_h_ml211.t3_1_1_1_2 hd_h_ml211.t3_1_1_4_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><b>H</b></td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_1 hd_h_ml211.t3_1_1_3_6" rowspan="1" colspan="1" style="background-color:#D9D9D9;text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_1 hd_h_ml211.t3_1_1_3_7" rowspan="1" colspan="1" style="background-color:#D9D9D9;text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_2 hd_h_ml211.t3_1_1_3_8 hd_h_ml211.t3_1_1_4_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_2 hd_h_ml211.t3_1_1_3_8 hd_h_ml211.t3_1_1_4_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_2 hd_h_ml211.t3_1_1_3_8 hd_h_ml211.t3_1_1_4_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_2 hd_h_ml211.t3_1_1_3_9 hd_h_ml211.t3_1_1_4_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_2 hd_h_ml211.t3_1_1_3_9 hd_h_ml211.t3_1_1_4_9" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_2 hd_h_ml211.t3_1_1_3_9 hd_h_ml211.t3_1_1_4_10" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_3 hd_h_ml211.t3_1_1_4_11" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_3 hd_h_ml211.t3_1_1_4_12" rowspan="1" colspan="1" style="background-color:#FFFF00;text-align:center;vertical-align:middle;">ABHD11</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_3 hd_h_ml211.t3_1_1_4_13" rowspan="1" colspan="1" style="background-color:#FFFF00;text-align:center;vertical-align:middle;">ABHD11</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_4 hd_h_ml211.t3_1_1_4_14" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_4 hd_h_ml211.t3_1_1_4_15" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0</td></tr><tr><td headers="hd_h_ml211.t3_1_1_1_1 hd_h_ml211.t3_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><b>1.3</b></td><td headers="hd_h_ml211.t3_1_1_1_1 hd_h_ml211.t3_1_1_3_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">AA34-1</td><td headers="hd_h_ml211.t3_1_1_1_1 hd_h_ml211.t3_1_1_3_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">CID 46937239</td><td headers="hd_h_ml211.t3_1_1_1_1 hd_h_ml211.t3_1_1_3_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/99445324" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">SID 99445324</a></td><td headers="hd_h_ml211.t3_1_1_1_1 hd_h_ml211.t3_1_1_3_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-02000000944-1</td><td headers="hd_h_ml211.t3_1_1_1_2 hd_h_ml211.t3_1_1_4_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><b>N2</b></td><td headers="hd_h_ml211.t3_1_1_1_2 hd_h_ml211.t3_1_1_4_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><b>H</b></td><td headers="hd_h_ml211.t3_1_1_1_2 hd_h_ml211.t3_1_1_4_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><b>O</b></td><td headers="hd_h_ml211.t3_1_1_1_2 hd_h_ml211.t3_1_1_4_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><b>Ph</b></td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_1 hd_h_ml211.t3_1_1_3_6" rowspan="1" colspan="1" style="background-color:#D9D9D9;text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_1 hd_h_ml211.t3_1_1_3_7" rowspan="1" colspan="1" style="background-color:#D9D9D9;text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_2 hd_h_ml211.t3_1_1_3_8 hd_h_ml211.t3_1_1_4_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_2 hd_h_ml211.t3_1_1_3_8 hd_h_ml211.t3_1_1_4_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_2 hd_h_ml211.t3_1_1_3_8 hd_h_ml211.t3_1_1_4_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_2 hd_h_ml211.t3_1_1_3_9 hd_h_ml211.t3_1_1_4_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_2 hd_h_ml211.t3_1_1_3_9 hd_h_ml211.t3_1_1_4_9" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_2 hd_h_ml211.t3_1_1_3_9 hd_h_ml211.t3_1_1_4_10" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_3 hd_h_ml211.t3_1_1_4_11" rowspan="1" colspan="1" style="background-color:#FFFF00;text-align:center;vertical-align:middle;">ABHD11</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_3 hd_h_ml211.t3_1_1_4_12" rowspan="1" colspan="1" style="background-color:#FFC000;text-align:center;vertical-align:middle;">ABHD11 ESD APEH</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_3 hd_h_ml211.t3_1_1_4_13" rowspan="1" colspan="1" style="background-color:#FFC000;text-align:center;vertical-align:middle;">ABHD11 ESD APEH</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_4 hd_h_ml211.t3_1_1_4_14" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_4 hd_h_ml211.t3_1_1_4_15" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0</td></tr><tr><td headers="hd_h_ml211.t3_1_1_1_1 hd_h_ml211.t3_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><b>1.4</b></td><td headers="hd_h_ml211.t3_1_1_1_1 hd_h_ml211.t3_1_1_3_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">AA34-2</td><td headers="hd_h_ml211.t3_1_1_1_1 hd_h_ml211.t3_1_1_3_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">CID 46937228</td><td headers="hd_h_ml211.t3_1_1_1_1 hd_h_ml211.t3_1_1_3_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/99445325" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">SID 99445325</a></td><td headers="hd_h_ml211.t3_1_1_1_1 hd_h_ml211.t3_1_1_3_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-02000000945-1</td><td headers="hd_h_ml211.t3_1_1_1_2 hd_h_ml211.t3_1_1_4_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><b>N2</b></td><td headers="hd_h_ml211.t3_1_1_1_2 hd_h_ml211.t3_1_1_4_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><b>H</b></td><td headers="hd_h_ml211.t3_1_1_1_2 hd_h_ml211.t3_1_1_4_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><b>O</b></td><td headers="hd_h_ml211.t3_1_1_1_2 hd_h_ml211.t3_1_1_4_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><b>3,5-difluoro Ph</b></td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_1 hd_h_ml211.t3_1_1_3_6" rowspan="1" colspan="1" style="background-color:#D9D9D9;text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_1 hd_h_ml211.t3_1_1_3_7" rowspan="1" colspan="1" style="background-color:#D9D9D9;text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_2 hd_h_ml211.t3_1_1_3_8 hd_h_ml211.t3_1_1_4_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_2 hd_h_ml211.t3_1_1_3_8 hd_h_ml211.t3_1_1_4_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_2 hd_h_ml211.t3_1_1_3_8 hd_h_ml211.t3_1_1_4_7" rowspan="1" colspan="1" style="background-color:#C4D79B;text-align:center;vertical-align:middle;">50</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_2 hd_h_ml211.t3_1_1_3_9 hd_h_ml211.t3_1_1_4_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_2 hd_h_ml211.t3_1_1_3_9 hd_h_ml211.t3_1_1_4_9" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_2 hd_h_ml211.t3_1_1_3_9 hd_h_ml211.t3_1_1_4_10" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_3 hd_h_ml211.t3_1_1_4_11" rowspan="1" colspan="1" style="background-color:#FFC000;text-align:center;vertical-align:middle;">ABHD11 APEH</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_3 hd_h_ml211.t3_1_1_4_12" rowspan="1" colspan="1" style="background-color:#FFC000;text-align:center;vertical-align:middle;">ABHD11 ESD APEH</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_3 hd_h_ml211.t3_1_1_4_13" rowspan="1" colspan="1" style="background-color:#FFC000;text-align:center;vertical-align:middle;">ABHD11 ESD APEH</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_4 hd_h_ml211.t3_1_1_4_14" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_4 hd_h_ml211.t3_1_1_4_15" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0</td></tr><tr><td headers="hd_h_ml211.t3_1_1_1_1 hd_h_ml211.t3_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><b>1.5</b></td><td headers="hd_h_ml211.t3_1_1_1_1 hd_h_ml211.t3_1_1_3_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">AA34-3</td><td headers="hd_h_ml211.t3_1_1_1_1 hd_h_ml211.t3_1_1_3_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">CID 46937230</td><td headers="hd_h_ml211.t3_1_1_1_1 hd_h_ml211.t3_1_1_3_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/99445326" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">SID 99445326</a></td><td headers="hd_h_ml211.t3_1_1_1_1 hd_h_ml211.t3_1_1_3_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-02000000946-1</td><td headers="hd_h_ml211.t3_1_1_1_2 hd_h_ml211.t3_1_1_4_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><b>N2</b></td><td headers="hd_h_ml211.t3_1_1_1_2 hd_h_ml211.t3_1_1_4_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><b>H</b></td><td headers="hd_h_ml211.t3_1_1_1_2 hd_h_ml211.t3_1_1_4_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><b>O</b></td><td headers="hd_h_ml211.t3_1_1_1_2 hd_h_ml211.t3_1_1_4_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><b>4-OCF<sub>3</sub> Ph</b></td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_1 hd_h_ml211.t3_1_1_3_6" rowspan="1" colspan="1" style="background-color:#D9D9D9;text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_1 hd_h_ml211.t3_1_1_3_7" rowspan="1" colspan="1" style="background-color:#D9D9D9;text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_2 hd_h_ml211.t3_1_1_3_8 hd_h_ml211.t3_1_1_4_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_2 hd_h_ml211.t3_1_1_3_8 hd_h_ml211.t3_1_1_4_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_2 hd_h_ml211.t3_1_1_3_8 hd_h_ml211.t3_1_1_4_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_2 hd_h_ml211.t3_1_1_3_9 hd_h_ml211.t3_1_1_4_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_2 hd_h_ml211.t3_1_1_3_9 hd_h_ml211.t3_1_1_4_9" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_2 hd_h_ml211.t3_1_1_3_9 hd_h_ml211.t3_1_1_4_10" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_3 hd_h_ml211.t3_1_1_4_11" rowspan="1" colspan="1" style="background-color:#FFFF00;text-align:center;vertical-align:middle;">ABHD11</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_3 hd_h_ml211.t3_1_1_4_12" rowspan="1" colspan="1" style="background-color:#FFFF00;text-align:center;vertical-align:middle;">ABHD11</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_3 hd_h_ml211.t3_1_1_4_13" rowspan="1" colspan="1" style="background-color:#FFC000;text-align:center;vertical-align:middle;">ABHD11 ESD APEH</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_4 hd_h_ml211.t3_1_1_4_14" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_4 hd_h_ml211.t3_1_1_4_15" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0</td></tr><tr><td headers="hd_h_ml211.t3_1_1_1_1 hd_h_ml211.t3_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><b>1.6</b></td><td headers="hd_h_ml211.t3_1_1_1_1 hd_h_ml211.t3_1_1_3_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">AA34-4</td><td headers="hd_h_ml211.t3_1_1_1_1 hd_h_ml211.t3_1_1_3_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">CID 46937235</td><td headers="hd_h_ml211.t3_1_1_1_1 hd_h_ml211.t3_1_1_3_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/99445327" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">SID 99445327</a></td><td headers="hd_h_ml211.t3_1_1_1_1 hd_h_ml211.t3_1_1_3_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-02000000947-1</td><td headers="hd_h_ml211.t3_1_1_1_2 hd_h_ml211.t3_1_1_4_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><b>N2</b></td><td headers="hd_h_ml211.t3_1_1_1_2 hd_h_ml211.t3_1_1_4_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><b>H</b></td><td headers="hd_h_ml211.t3_1_1_1_2 hd_h_ml211.t3_1_1_4_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><b>O</b></td><td headers="hd_h_ml211.t3_1_1_1_2 hd_h_ml211.t3_1_1_4_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><b>CPh<sub>2</sub>OH</b></td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_1 hd_h_ml211.t3_1_1_3_6" rowspan="1" colspan="1" style="background-color:#D9D9D9;text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_1 hd_h_ml211.t3_1_1_3_7" rowspan="1" colspan="1" style="background-color:#D9D9D9;text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_2 hd_h_ml211.t3_1_1_3_8 hd_h_ml211.t3_1_1_4_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_2 hd_h_ml211.t3_1_1_3_8 hd_h_ml211.t3_1_1_4_6" rowspan="1" colspan="1" style="background-color:#C4D79B;text-align:center;vertical-align:middle;">50</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_2 hd_h_ml211.t3_1_1_3_8 hd_h_ml211.t3_1_1_4_7" rowspan="1" colspan="1" style="background-color:#C4D79B;text-align:center;vertical-align:middle;">100</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_2 hd_h_ml211.t3_1_1_3_9 hd_h_ml211.t3_1_1_4_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_2 hd_h_ml211.t3_1_1_3_9 hd_h_ml211.t3_1_1_4_9" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_2 hd_h_ml211.t3_1_1_3_9 hd_h_ml211.t3_1_1_4_10" rowspan="1" colspan="1" style="background-color:#C4D79B;text-align:center;vertical-align:middle;">50</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_3 hd_h_ml211.t3_1_1_4_11" rowspan="1" colspan="1" style="background-color:#FFFF00;text-align:center;vertical-align:middle;">ABHD11</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_3 hd_h_ml211.t3_1_1_4_12" rowspan="1" colspan="1" style="background-color:#FFFF00;text-align:center;vertical-align:middle;">ABHD11</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_3 hd_h_ml211.t3_1_1_4_13" rowspan="1" colspan="1" style="background-color:#FFC000;text-align:center;vertical-align:middle;">ABHD11 ESD APEH</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_4 hd_h_ml211.t3_1_1_4_14" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_4 hd_h_ml211.t3_1_1_4_15" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0</td></tr><tr><td headers="hd_h_ml211.t3_1_1_1_1 hd_h_ml211.t3_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><b>1.7</b></td><td headers="hd_h_ml211.t3_1_1_1_1 hd_h_ml211.t3_1_1_3_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">AA26-9</td><td headers="hd_h_ml211.t3_1_1_1_1 hd_h_ml211.t3_1_1_3_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">CID 46829232</td><td headers="hd_h_ml211.t3_1_1_1_1 hd_h_ml211.t3_1_1_3_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/99205818" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">SID 99205818</a></td><td headers="hd_h_ml211.t3_1_1_1_1 hd_h_ml211.t3_1_1_3_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-02000000407-1</td><td headers="hd_h_ml211.t3_1_1_1_2 hd_h_ml211.t3_1_1_4_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><b>N1</b></td><td headers="hd_h_ml211.t3_1_1_1_2 hd_h_ml211.t3_1_1_4_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><b>H</b></td><td headers="hd_h_ml211.t3_1_1_1_2 hd_h_ml211.t3_1_1_4_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><b>CH<sub>2</sub></b></td><td headers="hd_h_ml211.t3_1_1_1_2 hd_h_ml211.t3_1_1_4_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><b>H</b></td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_1 hd_h_ml211.t3_1_1_3_6" rowspan="1" colspan="1" style="background-color:#D9D9D9;text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_1 hd_h_ml211.t3_1_1_3_7" rowspan="1" colspan="1" style="background-color:#D9D9D9;text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_2 hd_h_ml211.t3_1_1_3_8 hd_h_ml211.t3_1_1_4_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_2 hd_h_ml211.t3_1_1_3_8 hd_h_ml211.t3_1_1_4_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_2 hd_h_ml211.t3_1_1_3_8 hd_h_ml211.t3_1_1_4_7" rowspan="1" colspan="1" style="background-color:#C4D79B;text-align:center;vertical-align:middle;">75</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_2 hd_h_ml211.t3_1_1_3_9 hd_h_ml211.t3_1_1_4_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_2 hd_h_ml211.t3_1_1_3_9 hd_h_ml211.t3_1_1_4_9" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_2 hd_h_ml211.t3_1_1_3_9 hd_h_ml211.t3_1_1_4_10" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_3 hd_h_ml211.t3_1_1_4_11" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_3 hd_h_ml211.t3_1_1_4_12" rowspan="1" colspan="1" style="background-color:#FFFF00;text-align:center;vertical-align:middle;">ABHD11</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_3 hd_h_ml211.t3_1_1_4_13" rowspan="1" colspan="1" style="background-color:#FFFF00;text-align:center;vertical-align:middle;">ABHD11</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_4 hd_h_ml211.t3_1_1_4_14" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_4 hd_h_ml211.t3_1_1_4_15" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0</td></tr><tr><td headers="hd_h_ml211.t3_1_1_1_1 hd_h_ml211.t3_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><b>1.8</b></td><td headers="hd_h_ml211.t3_1_1_1_1 hd_h_ml211.t3_1_1_3_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">AA40-1</td><td headers="hd_h_ml211.t3_1_1_1_1 hd_h_ml211.t3_1_1_3_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">CID 46937232</td><td headers="hd_h_ml211.t3_1_1_1_1 hd_h_ml211.t3_1_1_3_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/99445331" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">SID 99445331</a></td><td headers="hd_h_ml211.t3_1_1_1_1 hd_h_ml211.t3_1_1_3_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-02000000951-1</td><td headers="hd_h_ml211.t3_1_1_1_2 hd_h_ml211.t3_1_1_4_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><b>N2</b></td><td headers="hd_h_ml211.t3_1_1_1_2 hd_h_ml211.t3_1_1_4_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><b>H</b></td><td headers="hd_h_ml211.t3_1_1_1_2 hd_h_ml211.t3_1_1_4_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><b>CH<sub>2</sub></b></td><td headers="hd_h_ml211.t3_1_1_1_2 hd_h_ml211.t3_1_1_4_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><b>CPh<sub>2</sub>OH</b></td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_1 hd_h_ml211.t3_1_1_3_6" rowspan="1" colspan="1" style="background-color:#D9D9D9;text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_1 hd_h_ml211.t3_1_1_3_7" rowspan="1" colspan="1" style="background-color:#D9D9D9;text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_2 hd_h_ml211.t3_1_1_3_8 hd_h_ml211.t3_1_1_4_5" rowspan="1" colspan="1" style="background-color:#C4D79B;text-align:center;vertical-align:middle;">100</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_2 hd_h_ml211.t3_1_1_3_8 hd_h_ml211.t3_1_1_4_6" rowspan="1" colspan="1" style="background-color:#C4D79B;text-align:center;vertical-align:middle;">100</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_2 hd_h_ml211.t3_1_1_3_8 hd_h_ml211.t3_1_1_4_7" rowspan="1" colspan="1" style="background-color:#C4D79B;text-align:center;vertical-align:middle;">100</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_2 hd_h_ml211.t3_1_1_3_9 hd_h_ml211.t3_1_1_4_8" rowspan="1" colspan="1" style="background-color:#C4D79B;text-align:center;vertical-align:middle;">25</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_2 hd_h_ml211.t3_1_1_3_9 hd_h_ml211.t3_1_1_4_9" rowspan="1" colspan="1" style="background-color:#C4D79B;text-align:center;vertical-align:middle;">50</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_2 hd_h_ml211.t3_1_1_3_9 hd_h_ml211.t3_1_1_4_10" rowspan="1" colspan="1" style="background-color:#C4D79B;text-align:center;vertical-align:middle;">100</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_3 hd_h_ml211.t3_1_1_4_11" rowspan="1" colspan="1" style="background-color:#FFFF00;text-align:center;vertical-align:middle;">ABHD11</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_3 hd_h_ml211.t3_1_1_4_12" rowspan="1" colspan="1" style="background-color:#FFC000;text-align:center;vertical-align:middle;">ABHD11 ESD</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_3 hd_h_ml211.t3_1_1_4_13" rowspan="1" colspan="1" style="background-color:#FFC000;text-align:center;vertical-align:middle;">ABHD11 ESD APEH</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_4 hd_h_ml211.t3_1_1_4_14" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_4 hd_h_ml211.t3_1_1_4_15" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0</td></tr><tr><td headers="hd_h_ml211.t3_1_1_1_1 hd_h_ml211.t3_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><b>1.9</b></td><td headers="hd_h_ml211.t3_1_1_1_1 hd_h_ml211.t3_1_1_3_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">AA40-2</td><td headers="hd_h_ml211.t3_1_1_1_1 hd_h_ml211.t3_1_1_3_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">CID 46937234</td><td headers="hd_h_ml211.t3_1_1_1_1 hd_h_ml211.t3_1_1_3_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/99445328" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">SID 99445328</a></td><td headers="hd_h_ml211.t3_1_1_1_1 hd_h_ml211.t3_1_1_3_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-02000000948-1</td><td headers="hd_h_ml211.t3_1_1_1_2 hd_h_ml211.t3_1_1_4_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><b>N2</b></td><td headers="hd_h_ml211.t3_1_1_1_2 hd_h_ml211.t3_1_1_4_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><b>H</b></td><td headers="hd_h_ml211.t3_1_1_1_2 hd_h_ml211.t3_1_1_4_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><b>CH<sub>2</sub></b></td><td headers="hd_h_ml211.t3_1_1_1_2 hd_h_ml211.t3_1_1_4_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><b>4-PhOPh</b></td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_1 hd_h_ml211.t3_1_1_3_6" rowspan="1" colspan="1" style="background-color:#D9D9D9;text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_1 hd_h_ml211.t3_1_1_3_7" rowspan="1" colspan="1" style="background-color:#D9D9D9;text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_2 hd_h_ml211.t3_1_1_3_8 hd_h_ml211.t3_1_1_4_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_2 hd_h_ml211.t3_1_1_3_8 hd_h_ml211.t3_1_1_4_6" rowspan="1" colspan="1" style="background-color:#C4D79B;text-align:center;vertical-align:middle;">50</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_2 hd_h_ml211.t3_1_1_3_8 hd_h_ml211.t3_1_1_4_7" rowspan="1" colspan="1" style="background-color:#C4D79B;text-align:center;vertical-align:middle;">100</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_2 hd_h_ml211.t3_1_1_3_9 hd_h_ml211.t3_1_1_4_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_2 hd_h_ml211.t3_1_1_3_9 hd_h_ml211.t3_1_1_4_9" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_2 hd_h_ml211.t3_1_1_3_9 hd_h_ml211.t3_1_1_4_10" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_3 hd_h_ml211.t3_1_1_4_11" rowspan="1" colspan="1" style="background-color:#FFC000;text-align:center;vertical-align:middle;">ABHD11 ESD</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_3 hd_h_ml211.t3_1_1_4_12" rowspan="1" colspan="1" style="background-color:#FFC000;text-align:center;vertical-align:middle;">ABHD11 ESD</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_3 hd_h_ml211.t3_1_1_4_13" rowspan="1" colspan="1" style="background-color:#FFC000;text-align:center;vertical-align:middle;">ABHD11 ESD</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_4 hd_h_ml211.t3_1_1_4_14" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_4 hd_h_ml211.t3_1_1_4_15" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0</td></tr><tr><td headers="hd_h_ml211.t3_1_1_1_1 hd_h_ml211.t3_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><b>1.10</b></td><td headers="hd_h_ml211.t3_1_1_1_1 hd_h_ml211.t3_1_1_3_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">AA40-3</td><td headers="hd_h_ml211.t3_1_1_1_1 hd_h_ml211.t3_1_1_3_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">CID 46937227</td><td headers="hd_h_ml211.t3_1_1_1_1 hd_h_ml211.t3_1_1_3_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/99445329" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">SID 99445329</a></td><td headers="hd_h_ml211.t3_1_1_1_1 hd_h_ml211.t3_1_1_3_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-02000000949-1</td><td headers="hd_h_ml211.t3_1_1_1_2 hd_h_ml211.t3_1_1_4_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><b>N2</b></td><td headers="hd_h_ml211.t3_1_1_1_2 hd_h_ml211.t3_1_1_4_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><b>H</b></td><td headers="hd_h_ml211.t3_1_1_1_2 hd_h_ml211.t3_1_1_4_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><b>CH<sub>2</sub></b></td><td headers="hd_h_ml211.t3_1_1_1_2 hd_h_ml211.t3_1_1_4_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><b>6-OMe naphthal</b></td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_1 hd_h_ml211.t3_1_1_3_6" rowspan="1" colspan="1" style="background-color:#D9D9D9;text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_1 hd_h_ml211.t3_1_1_3_7" rowspan="1" colspan="1" style="background-color:#D9D9D9;text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_2 hd_h_ml211.t3_1_1_3_8 hd_h_ml211.t3_1_1_4_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_2 hd_h_ml211.t3_1_1_3_8 hd_h_ml211.t3_1_1_4_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_2 hd_h_ml211.t3_1_1_3_8 hd_h_ml211.t3_1_1_4_7" rowspan="1" colspan="1" style="background-color:#C4D79B;text-align:center;vertical-align:middle;">100</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_2 hd_h_ml211.t3_1_1_3_9 hd_h_ml211.t3_1_1_4_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_2 hd_h_ml211.t3_1_1_3_9 hd_h_ml211.t3_1_1_4_9" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_2 hd_h_ml211.t3_1_1_3_9 hd_h_ml211.t3_1_1_4_10" rowspan="1" colspan="1" style="background-color:#C4D79B;text-align:center;vertical-align:middle;">50</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_3 hd_h_ml211.t3_1_1_4_11" rowspan="1" colspan="1" style="background-color:#FFC000;text-align:center;vertical-align:middle;">ABHD11 ESD</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_3 hd_h_ml211.t3_1_1_4_12" rowspan="1" colspan="1" style="background-color:#FFC000;text-align:center;vertical-align:middle;">ABHD11 ESD</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_3 hd_h_ml211.t3_1_1_4_13" rowspan="1" colspan="1" style="background-color:#FFC000;text-align:center;vertical-align:middle;">ABHD11 ESD APEH</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_4 hd_h_ml211.t3_1_1_4_14" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_4 hd_h_ml211.t3_1_1_4_15" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0</td></tr><tr><td headers="hd_h_ml211.t3_1_1_1_1 hd_h_ml211.t3_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><b>1.11</b></td><td headers="hd_h_ml211.t3_1_1_1_1 hd_h_ml211.t3_1_1_3_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">AA47-1</td><td headers="hd_h_ml211.t3_1_1_1_1 hd_h_ml211.t3_1_1_3_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">CID 46937241</td><td headers="hd_h_ml211.t3_1_1_1_1 hd_h_ml211.t3_1_1_3_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/99445330" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">SID 99445330</a></td><td headers="hd_h_ml211.t3_1_1_1_1 hd_h_ml211.t3_1_1_3_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-02000000950-1</td><td headers="hd_h_ml211.t3_1_1_1_2 hd_h_ml211.t3_1_1_4_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><b>N2</b></td><td headers="hd_h_ml211.t3_1_1_1_2 hd_h_ml211.t3_1_1_4_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><b>H</b></td><td headers="hd_h_ml211.t3_1_1_1_2 hd_h_ml211.t3_1_1_4_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><b>CH<sub>2</sub></b></td><td headers="hd_h_ml211.t3_1_1_1_2 hd_h_ml211.t3_1_1_4_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><b>CHPhOH</b></td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_1 hd_h_ml211.t3_1_1_3_6" rowspan="1" colspan="1" style="background-color:#D9D9D9;text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_1 hd_h_ml211.t3_1_1_3_7" rowspan="1" colspan="1" style="background-color:#D9D9D9;text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_2 hd_h_ml211.t3_1_1_3_8 hd_h_ml211.t3_1_1_4_5" rowspan="1" colspan="1" style="background-color:#C4D79B;text-align:center;vertical-align:middle;">75</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_2 hd_h_ml211.t3_1_1_3_8 hd_h_ml211.t3_1_1_4_6" rowspan="1" colspan="1" style="background-color:#C4D79B;text-align:center;vertical-align:middle;">100</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_2 hd_h_ml211.t3_1_1_3_8 hd_h_ml211.t3_1_1_4_7" rowspan="1" colspan="1" style="background-color:#C4D79B;text-align:center;vertical-align:middle;">100</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_2 hd_h_ml211.t3_1_1_3_9 hd_h_ml211.t3_1_1_4_8" rowspan="1" colspan="1" style="background-color:#C4D79B;text-align:center;vertical-align:middle;">25</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_2 hd_h_ml211.t3_1_1_3_9 hd_h_ml211.t3_1_1_4_9" rowspan="1" colspan="1" style="background-color:#C4D79B;text-align:center;vertical-align:middle;">50</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_2 hd_h_ml211.t3_1_1_3_9 hd_h_ml211.t3_1_1_4_10" rowspan="1" colspan="1" style="background-color:#C4D79B;text-align:center;vertical-align:middle;">75</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_3 hd_h_ml211.t3_1_1_4_11" rowspan="1" colspan="1" style="background-color:#FFFF00;text-align:center;vertical-align:middle;">ABHD11</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_3 hd_h_ml211.t3_1_1_4_12" rowspan="1" colspan="1" style="background-color:#FFC000;text-align:center;vertical-align:middle;">ABHD11 ESD</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_3 hd_h_ml211.t3_1_1_4_13" rowspan="1" colspan="1" style="background-color:#FFC000;text-align:center;vertical-align:middle;">ABHD11 ESD</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_4 hd_h_ml211.t3_1_1_4_14" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_4 hd_h_ml211.t3_1_1_4_15" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0</td></tr><tr><td headers="hd_h_ml211.t3_1_1_1_1 hd_h_ml211.t3_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><b>1.12 (<a href="/pcsubstance/?term=ML226[synonym]" ref="pagearea=body&targetsite=entrez&targetcat=term&targettype=pubchem">ML226</a>)</b></td><td headers="hd_h_ml211.t3_1_1_1_1 hd_h_ml211.t3_1_1_3_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">AA44-1</td><td headers="hd_h_ml211.t3_1_1_1_1 hd_h_ml211.t3_1_1_3_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">CID 46937236</td><td headers="hd_h_ml211.t3_1_1_1_1 hd_h_ml211.t3_1_1_3_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/99445332" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">SID 99445332</a></td><td headers="hd_h_ml211.t3_1_1_1_1 hd_h_ml211.t3_1_1_3_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-02000000952-1</td><td headers="hd_h_ml211.t3_1_1_1_2 hd_h_ml211.t3_1_1_4_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><b>N2</b></td><td headers="hd_h_ml211.t3_1_1_1_2 hd_h_ml211.t3_1_1_4_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><b>2-Et</b></td><td headers="hd_h_ml211.t3_1_1_1_2 hd_h_ml211.t3_1_1_4_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><b>CH<sub>2</sub></b></td><td headers="hd_h_ml211.t3_1_1_1_2 hd_h_ml211.t3_1_1_4_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><b>CPh<sub>2</sub>OH</b></td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_1 hd_h_ml211.t3_1_1_3_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">>10000</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_1 hd_h_ml211.t3_1_1_3_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">>10000</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_2 hd_h_ml211.t3_1_1_3_8 hd_h_ml211.t3_1_1_4_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_2 hd_h_ml211.t3_1_1_3_8 hd_h_ml211.t3_1_1_4_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_2 hd_h_ml211.t3_1_1_3_8 hd_h_ml211.t3_1_1_4_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_2 hd_h_ml211.t3_1_1_3_9 hd_h_ml211.t3_1_1_4_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_2 hd_h_ml211.t3_1_1_3_9 hd_h_ml211.t3_1_1_4_9" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_2 hd_h_ml211.t3_1_1_3_9 hd_h_ml211.t3_1_1_4_10" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_3 hd_h_ml211.t3_1_1_4_11" rowspan="1" colspan="1" style="background-color:#FFFF00;text-align:center;vertical-align:middle;">ABHD11</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_3 hd_h_ml211.t3_1_1_4_12" rowspan="1" colspan="1" style="background-color:#FFFF00;text-align:center;vertical-align:middle;">ABHD11</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_3 hd_h_ml211.t3_1_1_4_13" rowspan="1" colspan="1" style="background-color:#FFC000;text-align:center;vertical-align:middle;">ABHD11 APEH</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_4 hd_h_ml211.t3_1_1_4_14" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_4 hd_h_ml211.t3_1_1_4_15" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0</td></tr><tr><td headers="hd_h_ml211.t3_1_1_1_1 hd_h_ml211.t3_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><b>1.13</b></td><td headers="hd_h_ml211.t3_1_1_1_1 hd_h_ml211.t3_1_1_3_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">KLH31</td><td headers="hd_h_ml211.t3_1_1_1_1 hd_h_ml211.t3_1_1_3_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">CID 46937238</td><td headers="hd_h_ml211.t3_1_1_1_1 hd_h_ml211.t3_1_1_3_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/99445333" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">SID 99445333</a></td><td headers="hd_h_ml211.t3_1_1_1_1 hd_h_ml211.t3_1_1_3_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-02000000953-1</td><td headers="hd_h_ml211.t3_1_1_1_2 hd_h_ml211.t3_1_1_4_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><b>N1</b></td><td headers="hd_h_ml211.t3_1_1_1_2 hd_h_ml211.t3_1_1_4_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><b>3-Bz</b></td><td headers="hd_h_ml211.t3_1_1_1_2 hd_h_ml211.t3_1_1_4_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><b>CH<sub>2</sub></b></td><td headers="hd_h_ml211.t3_1_1_1_2 hd_h_ml211.t3_1_1_4_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><b>CPh<sub>2</sub>OH</b></td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_1 hd_h_ml211.t3_1_1_3_6" rowspan="1" colspan="1" style="background-color:#D9D9D9;text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_1 hd_h_ml211.t3_1_1_3_7" rowspan="1" colspan="1" style="background-color:#D9D9D9;text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_2 hd_h_ml211.t3_1_1_3_8 hd_h_ml211.t3_1_1_4_5" rowspan="1" colspan="1" style="background-color:#C4D79B;text-align:center;vertical-align:middle;">50</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_2 hd_h_ml211.t3_1_1_3_8 hd_h_ml211.t3_1_1_4_6" rowspan="1" colspan="1" style="background-color:#C4D79B;text-align:center;vertical-align:middle;">100</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_2 hd_h_ml211.t3_1_1_3_8 hd_h_ml211.t3_1_1_4_7" rowspan="1" colspan="1" style="background-color:#C4D79B;text-align:center;vertical-align:middle;">100</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_2 hd_h_ml211.t3_1_1_3_9 hd_h_ml211.t3_1_1_4_8" rowspan="1" colspan="1" style="background-color:#C4D79B;text-align:center;vertical-align:middle;">50</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_2 hd_h_ml211.t3_1_1_3_9 hd_h_ml211.t3_1_1_4_9" rowspan="1" colspan="1" style="background-color:#C4D79B;text-align:center;vertical-align:middle;">75</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_2 hd_h_ml211.t3_1_1_3_9 hd_h_ml211.t3_1_1_4_10" rowspan="1" colspan="1" style="background-color:#C4D79B;text-align:center;vertical-align:middle;">100</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_3 hd_h_ml211.t3_1_1_4_11" rowspan="1" colspan="1" style="background-color:#FFFF00;text-align:center;vertical-align:middle;">ABHD11</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_3 hd_h_ml211.t3_1_1_4_12" rowspan="1" colspan="1" style="background-color:#FFFF00;text-align:center;vertical-align:middle;">ABHD11</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_3 hd_h_ml211.t3_1_1_4_13" rowspan="1" colspan="1" style="background-color:#FFC000;text-align:center;vertical-align:middle;">ABHD11 ESD</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_4 hd_h_ml211.t3_1_1_4_14" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_4 hd_h_ml211.t3_1_1_4_15" rowspan="1" colspan="1" style="background-color:#C4D79B;text-align:center;vertical-align:middle;">50</td></tr><tr><td headers="hd_h_ml211.t3_1_1_1_1 hd_h_ml211.t3_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><b>1.14</b></td><td headers="hd_h_ml211.t3_1_1_1_1 hd_h_ml211.t3_1_1_3_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">AA44-3</td><td headers="hd_h_ml211.t3_1_1_1_1 hd_h_ml211.t3_1_1_3_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">CID 46937244</td><td headers="hd_h_ml211.t3_1_1_1_1 hd_h_ml211.t3_1_1_3_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/99445334" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">SID 99445334</a></td><td headers="hd_h_ml211.t3_1_1_1_1 hd_h_ml211.t3_1_1_3_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-02000000954-1</td><td headers="hd_h_ml211.t3_1_1_1_2 hd_h_ml211.t3_1_1_4_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><b>N2</b></td><td headers="hd_h_ml211.t3_1_1_1_2 hd_h_ml211.t3_1_1_4_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><b>4-Me</b></td><td headers="hd_h_ml211.t3_1_1_1_2 hd_h_ml211.t3_1_1_4_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><b>CH</b></td><td headers="hd_h_ml211.t3_1_1_1_2 hd_h_ml211.t3_1_1_4_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><b>CPh<sub>2</sub>OH</b></td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_1 hd_h_ml211.t3_1_1_3_6" rowspan="1" colspan="1" style="background-color:#D9D9D9;text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_1 hd_h_ml211.t3_1_1_3_7" rowspan="1" colspan="1" style="background-color:#D9D9D9;text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_2 hd_h_ml211.t3_1_1_3_8 hd_h_ml211.t3_1_1_4_5" rowspan="1" colspan="1" style="background-color:#C4D79B;text-align:center;vertical-align:middle;">100</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_2 hd_h_ml211.t3_1_1_3_8 hd_h_ml211.t3_1_1_4_6" rowspan="1" colspan="1" style="background-color:#C4D79B;text-align:center;vertical-align:middle;">100</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_2 hd_h_ml211.t3_1_1_3_8 hd_h_ml211.t3_1_1_4_7" rowspan="1" colspan="1" style="background-color:#C4D79B;text-align:center;vertical-align:middle;">100</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_2 hd_h_ml211.t3_1_1_3_9 hd_h_ml211.t3_1_1_4_8" rowspan="1" colspan="1" style="background-color:#C4D79B;text-align:center;vertical-align:middle;">50</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_2 hd_h_ml211.t3_1_1_3_9 hd_h_ml211.t3_1_1_4_9" rowspan="1" colspan="1" style="background-color:#C4D79B;text-align:center;vertical-align:middle;">75</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_2 hd_h_ml211.t3_1_1_3_9 hd_h_ml211.t3_1_1_4_10" rowspan="1" colspan="1" style="background-color:#C4D79B;text-align:center;vertical-align:middle;">100</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_3 hd_h_ml211.t3_1_1_4_11" rowspan="1" colspan="1" style="background-color:#FFFF00;text-align:center;vertical-align:middle;">ABHD11</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_3 hd_h_ml211.t3_1_1_4_12" rowspan="1" colspan="1" style="background-color:#FFC000;text-align:center;vertical-align:middle;">ABHD11 APEH</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_3 hd_h_ml211.t3_1_1_4_13" rowspan="1" colspan="1" style="background-color:#FFC000;text-align:center;vertical-align:middle;">ABHD11 ESD APEH</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_4 hd_h_ml211.t3_1_1_4_14" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_4 hd_h_ml211.t3_1_1_4_15" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0</td></tr><tr><td headers="hd_h_ml211.t3_1_1_1_1 hd_h_ml211.t3_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><b>1.15</b></td><td headers="hd_h_ml211.t3_1_1_1_1 hd_h_ml211.t3_1_1_3_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">AA49-1</td><td headers="hd_h_ml211.t3_1_1_1_1 hd_h_ml211.t3_1_1_3_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">CID 46937233</td><td headers="hd_h_ml211.t3_1_1_1_1 hd_h_ml211.t3_1_1_3_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/99445335" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">SID 99445335</a></td><td headers="hd_h_ml211.t3_1_1_1_1 hd_h_ml211.t3_1_1_3_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-02000000955-1</td><td headers="hd_h_ml211.t3_1_1_1_2 hd_h_ml211.t3_1_1_4_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><b>N2</b></td><td headers="hd_h_ml211.t3_1_1_1_2 hd_h_ml211.t3_1_1_4_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><b>4-OMe</b></td><td headers="hd_h_ml211.t3_1_1_1_2 hd_h_ml211.t3_1_1_4_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><b>CH</b></td><td headers="hd_h_ml211.t3_1_1_1_2 hd_h_ml211.t3_1_1_4_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><b>CPh<sub>2</sub>OH</b></td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_1 hd_h_ml211.t3_1_1_3_6" rowspan="1" colspan="1" style="background-color:#D9D9D9;text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_1 hd_h_ml211.t3_1_1_3_7" rowspan="1" colspan="1" style="background-color:#D9D9D9;text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_2 hd_h_ml211.t3_1_1_3_8 hd_h_ml211.t3_1_1_4_5" rowspan="1" colspan="1" style="background-color:#C4D79B;text-align:center;vertical-align:middle;">50</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_2 hd_h_ml211.t3_1_1_3_8 hd_h_ml211.t3_1_1_4_6" rowspan="1" colspan="1" style="background-color:#C4D79B;text-align:center;vertical-align:middle;">100</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_2 hd_h_ml211.t3_1_1_3_8 hd_h_ml211.t3_1_1_4_7" rowspan="1" colspan="1" style="background-color:#C4D79B;text-align:center;vertical-align:middle;">100</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_2 hd_h_ml211.t3_1_1_3_9 hd_h_ml211.t3_1_1_4_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_2 hd_h_ml211.t3_1_1_3_9 hd_h_ml211.t3_1_1_4_9" rowspan="1" colspan="1" style="background-color:#C4D79B;text-align:center;vertical-align:middle;">50</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_2 hd_h_ml211.t3_1_1_3_9 hd_h_ml211.t3_1_1_4_10" rowspan="1" colspan="1" style="background-color:#C4D79B;text-align:center;vertical-align:middle;">100</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_3 hd_h_ml211.t3_1_1_4_11" rowspan="1" colspan="1" style="background-color:#FFFF00;text-align:center;vertical-align:middle;">ABHD11</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_3 hd_h_ml211.t3_1_1_4_12" rowspan="1" colspan="1" style="background-color:#FFFF00;text-align:center;vertical-align:middle;">ABHD11</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_3 hd_h_ml211.t3_1_1_4_13" rowspan="1" colspan="1" style="background-color:#FFC000;text-align:center;vertical-align:middle;">ABHD11 ESD</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_4 hd_h_ml211.t3_1_1_4_14" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_4 hd_h_ml211.t3_1_1_4_15" rowspan="1" colspan="1" style="background-color:#D9D9D9;text-align:center;vertical-align:middle;">ND</td></tr><tr><td headers="hd_h_ml211.t3_1_1_1_1 hd_h_ml211.t3_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><b>1.16</b></td><td headers="hd_h_ml211.t3_1_1_1_1 hd_h_ml211.t3_1_1_3_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">AA50-1</td><td headers="hd_h_ml211.t3_1_1_1_1 hd_h_ml211.t3_1_1_3_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">CID 46937231</td><td headers="hd_h_ml211.t3_1_1_1_1 hd_h_ml211.t3_1_1_3_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/99445336" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">SID 99445336</a></td><td headers="hd_h_ml211.t3_1_1_1_1 hd_h_ml211.t3_1_1_3_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-02000000956-1</td><td headers="hd_h_ml211.t3_1_1_1_2 hd_h_ml211.t3_1_1_4_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><b>N2</b></td><td headers="hd_h_ml211.t3_1_1_1_2 hd_h_ml211.t3_1_1_4_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><b>4-Bz</b></td><td headers="hd_h_ml211.t3_1_1_1_2 hd_h_ml211.t3_1_1_4_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><b>CH</b></td><td headers="hd_h_ml211.t3_1_1_1_2 hd_h_ml211.t3_1_1_4_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><b>CPh<sub>2</sub>OH</b></td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_1 hd_h_ml211.t3_1_1_3_6" rowspan="1" colspan="1" style="background-color:#D9D9D9;text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_1 hd_h_ml211.t3_1_1_3_7" rowspan="1" colspan="1" style="background-color:#D9D9D9;text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_2 hd_h_ml211.t3_1_1_3_8 hd_h_ml211.t3_1_1_4_5" rowspan="1" colspan="1" style="background-color:#C4D79B;text-align:center;vertical-align:middle;">75</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_2 hd_h_ml211.t3_1_1_3_8 hd_h_ml211.t3_1_1_4_6" rowspan="1" colspan="1" style="background-color:#C4D79B;text-align:center;vertical-align:middle;">100</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_2 hd_h_ml211.t3_1_1_3_8 hd_h_ml211.t3_1_1_4_7" rowspan="1" colspan="1" style="background-color:#C4D79B;text-align:center;vertical-align:middle;">100</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_2 hd_h_ml211.t3_1_1_3_9 hd_h_ml211.t3_1_1_4_8" rowspan="1" colspan="1" style="background-color:#C4D79B;text-align:center;vertical-align:middle;">50</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_2 hd_h_ml211.t3_1_1_3_9 hd_h_ml211.t3_1_1_4_9" rowspan="1" colspan="1" style="background-color:#C4D79B;text-align:center;vertical-align:middle;">100</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_2 hd_h_ml211.t3_1_1_3_9 hd_h_ml211.t3_1_1_4_10" rowspan="1" colspan="1" style="background-color:#C4D79B;text-align:center;vertical-align:middle;">100</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_3 hd_h_ml211.t3_1_1_4_11" rowspan="1" colspan="1" style="background-color:#FFFF00;text-align:center;vertical-align:middle;">ABHD11</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_3 hd_h_ml211.t3_1_1_4_12" rowspan="1" colspan="1" style="background-color:#FFFF00;text-align:center;vertical-align:middle;">ABHD11</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_3 hd_h_ml211.t3_1_1_4_13" rowspan="1" colspan="1" style="background-color:#FFC000;text-align:center;vertical-align:middle;">ABHD11 ESD</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_4 hd_h_ml211.t3_1_1_4_14" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_4 hd_h_ml211.t3_1_1_4_15" rowspan="1" colspan="1" style="background-color:#C4D79B;text-align:center;vertical-align:middle;">>7</td></tr><tr><td headers="hd_h_ml211.t3_1_1_1_1 hd_h_ml211.t3_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><b>1.17</b></td><td headers="hd_h_ml211.t3_1_1_1_1 hd_h_ml211.t3_1_1_3_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">AA62-2</td><td headers="hd_h_ml211.t3_1_1_1_1 hd_h_ml211.t3_1_1_3_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">CID 46937243</td><td headers="hd_h_ml211.t3_1_1_1_1 hd_h_ml211.t3_1_1_3_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/99445337" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">SID 99445337</a></td><td headers="hd_h_ml211.t3_1_1_1_1 hd_h_ml211.t3_1_1_3_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-02000000957-1</td><td headers="hd_h_ml211.t3_1_1_1_2 hd_h_ml211.t3_1_1_4_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><b>N2</b></td><td headers="hd_h_ml211.t3_1_1_1_2 hd_h_ml211.t3_1_1_4_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><b>4-CPh<sub>2</sub>OH</b></td><td headers="hd_h_ml211.t3_1_1_1_2 hd_h_ml211.t3_1_1_4_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><b>CH</b></td><td headers="hd_h_ml211.t3_1_1_1_2 hd_h_ml211.t3_1_1_4_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><b>CPh<sub>2</sub>OH</b></td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_1 hd_h_ml211.t3_1_1_3_6" rowspan="1" colspan="1" style="background-color:#D9D9D9;text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_1 hd_h_ml211.t3_1_1_3_7" rowspan="1" colspan="1" style="background-color:#D9D9D9;text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_2 hd_h_ml211.t3_1_1_3_8 hd_h_ml211.t3_1_1_4_5" rowspan="1" colspan="1" style="background-color:#C4D79B;text-align:center;vertical-align:middle;">50</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_2 hd_h_ml211.t3_1_1_3_8 hd_h_ml211.t3_1_1_4_6" rowspan="1" colspan="1" style="background-color:#C4D79B;text-align:center;vertical-align:middle;">100</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_2 hd_h_ml211.t3_1_1_3_8 hd_h_ml211.t3_1_1_4_7" rowspan="1" colspan="1" style="background-color:#C4D79B;text-align:center;vertical-align:middle;">100</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_2 hd_h_ml211.t3_1_1_3_9 hd_h_ml211.t3_1_1_4_8" rowspan="1" colspan="1" style="background-color:#C4D79B;text-align:center;vertical-align:middle;">50</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_2 hd_h_ml211.t3_1_1_3_9 hd_h_ml211.t3_1_1_4_9" rowspan="1" colspan="1" style="background-color:#C4D79B;text-align:center;vertical-align:middle;">100</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_2 hd_h_ml211.t3_1_1_3_9 hd_h_ml211.t3_1_1_4_10" rowspan="1" colspan="1" style="background-color:#C4D79B;text-align:center;vertical-align:middle;">100</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_3 hd_h_ml211.t3_1_1_4_11" rowspan="1" colspan="1" style="background-color:#FFFF00;text-align:center;vertical-align:middle;">ABHD11</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_3 hd_h_ml211.t3_1_1_4_12" rowspan="1" colspan="1" style="background-color:#FFFF00;text-align:center;vertical-align:middle;">ABHD11</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_3 hd_h_ml211.t3_1_1_4_13" rowspan="1" colspan="1" style="background-color:#FFFF00;text-align:center;vertical-align:middle;">ABHD11</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_4 hd_h_ml211.t3_1_1_4_14" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_4 hd_h_ml211.t3_1_1_4_15" rowspan="1" colspan="1" style="background-color:#C4D79B;text-align:center;vertical-align:middle;">>50</td></tr><tr><td headers="hd_h_ml211.t3_1_1_1_1 hd_h_ml211.t3_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><b>1.18 (<a href="/pcsubstance/?term=ML211[synonym]" ref="pagearea=body&targetsite=entrez&targetcat=term&targettype=pubchem">ML211</a>)</b></td><td headers="hd_h_ml211.t3_1_1_1_1 hd_h_ml211.t3_1_1_3_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">AA64-2</td><td headers="hd_h_ml211.t3_1_1_1_1 hd_h_ml211.t3_1_1_3_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">CID 56593118</td><td headers="hd_h_ml211.t3_1_1_1_1 hd_h_ml211.t3_1_1_3_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/99445338" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">SID 99445338</a></td><td headers="hd_h_ml211.t3_1_1_1_1 hd_h_ml211.t3_1_1_3_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-02000000958-1</td><td headers="hd_h_ml211.t3_1_1_1_2 hd_h_ml211.t3_1_1_4_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><b>N2</b></td><td headers="hd_h_ml211.t3_1_1_1_2 hd_h_ml211.t3_1_1_4_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><b>4-tBu</b></td><td headers="hd_h_ml211.t3_1_1_1_2 hd_h_ml211.t3_1_1_4_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><b>CH</b></td><td headers="hd_h_ml211.t3_1_1_1_2 hd_h_ml211.t3_1_1_4_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><b>CPh<sub>2</sub>OH</b></td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_1 hd_h_ml211.t3_1_1_3_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">17</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_1 hd_h_ml211.t3_1_1_3_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">30</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_2 hd_h_ml211.t3_1_1_3_8 hd_h_ml211.t3_1_1_4_5" rowspan="1" colspan="1" style="background-color:#C4D79B;text-align:center;vertical-align:middle;">100</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_2 hd_h_ml211.t3_1_1_3_8 hd_h_ml211.t3_1_1_4_6" rowspan="1" colspan="1" style="background-color:#C4D79B;text-align:center;vertical-align:middle;">100</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_2 hd_h_ml211.t3_1_1_3_8 hd_h_ml211.t3_1_1_4_7" rowspan="1" colspan="1" style="background-color:#C4D79B;text-align:center;vertical-align:middle;">100</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_2 hd_h_ml211.t3_1_1_3_9 hd_h_ml211.t3_1_1_4_8" rowspan="1" colspan="1" style="background-color:#C4D79B;text-align:center;vertical-align:middle;">50</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_2 hd_h_ml211.t3_1_1_3_9 hd_h_ml211.t3_1_1_4_9" rowspan="1" colspan="1" style="background-color:#C4D79B;text-align:center;vertical-align:middle;">100</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_2 hd_h_ml211.t3_1_1_3_9 hd_h_ml211.t3_1_1_4_10" rowspan="1" colspan="1" style="background-color:#C4D79B;text-align:center;vertical-align:middle;">100</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_3 hd_h_ml211.t3_1_1_4_11" rowspan="1" colspan="1" style="background-color:#FFFF00;text-align:center;vertical-align:middle;">ABHD11</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_3 hd_h_ml211.t3_1_1_4_12" rowspan="1" colspan="1" style="background-color:#FFFF00;text-align:center;vertical-align:middle;">ABHD11</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_3 hd_h_ml211.t3_1_1_4_13" rowspan="1" colspan="1" style="background-color:#FFC000;text-align:center;vertical-align:middle;">ABHD11 ESD</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_4 hd_h_ml211.t3_1_1_4_14" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_4 hd_h_ml211.t3_1_1_4_15" rowspan="1" colspan="1" style="background-color:#C4D79B;text-align:center;vertical-align:middle;">50</td></tr><tr><td headers="hd_h_ml211.t3_1_1_1_1 hd_h_ml211.t3_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><b>1.19</b></td><td headers="hd_h_ml211.t3_1_1_1_1 hd_h_ml211.t3_1_1_3_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">AA69-1</td><td headers="hd_h_ml211.t3_1_1_1_1 hd_h_ml211.t3_1_1_3_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">CID 46937229</td><td headers="hd_h_ml211.t3_1_1_1_1 hd_h_ml211.t3_1_1_3_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/99445339" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">SID 99445339</a></td><td headers="hd_h_ml211.t3_1_1_1_1 hd_h_ml211.t3_1_1_3_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-02000000959-1</td><td headers="hd_h_ml211.t3_1_1_1_2 hd_h_ml211.t3_1_1_4_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><b>N2</b></td><td headers="hd_h_ml211.t3_1_1_1_2 hd_h_ml211.t3_1_1_4_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><b>4-tBu</b></td><td headers="hd_h_ml211.t3_1_1_1_2 hd_h_ml211.t3_1_1_4_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><b>CH</b></td><td headers="hd_h_ml211.t3_1_1_1_2 hd_h_ml211.t3_1_1_4_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><b>Cyclohexan (1)ol</b></td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_1 hd_h_ml211.t3_1_1_3_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">35</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_1 hd_h_ml211.t3_1_1_3_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">57</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_2 hd_h_ml211.t3_1_1_3_8 hd_h_ml211.t3_1_1_4_5" rowspan="1" colspan="1" style="background-color:#C4D79B;text-align:center;vertical-align:middle;">50</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_2 hd_h_ml211.t3_1_1_3_8 hd_h_ml211.t3_1_1_4_6" rowspan="1" colspan="1" style="background-color:#C4D79B;text-align:center;vertical-align:middle;">100</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_2 hd_h_ml211.t3_1_1_3_8 hd_h_ml211.t3_1_1_4_7" rowspan="1" colspan="1" style="background-color:#C4D79B;text-align:center;vertical-align:middle;">100</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_2 hd_h_ml211.t3_1_1_3_9 hd_h_ml211.t3_1_1_4_8" rowspan="1" colspan="1" style="background-color:#C4D79B;text-align:center;vertical-align:middle;">25</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_2 hd_h_ml211.t3_1_1_3_9 hd_h_ml211.t3_1_1_4_9" rowspan="1" colspan="1" style="background-color:#C4D79B;text-align:center;vertical-align:middle;">95</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_2 hd_h_ml211.t3_1_1_3_9 hd_h_ml211.t3_1_1_4_10" rowspan="1" colspan="1" style="background-color:#C4D79B;text-align:center;vertical-align:middle;">100</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_3 hd_h_ml211.t3_1_1_4_11" rowspan="1" colspan="1" style="background-color:#FFFF00;text-align:center;vertical-align:middle;">ABHD11</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_3 hd_h_ml211.t3_1_1_4_12" rowspan="1" colspan="1" style="background-color:#FFFF00;text-align:center;vertical-align:middle;">ABHD11</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_3 hd_h_ml211.t3_1_1_4_13" rowspan="1" colspan="1" style="background-color:#FFC000;text-align:center;vertical-align:middle;">ABHD11 ESD</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_4 hd_h_ml211.t3_1_1_4_14" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_4 hd_h_ml211.t3_1_1_4_15" rowspan="1" colspan="1" style="background-color:#C4D79B;text-align:center;vertical-align:middle;">>7</td></tr><tr><td headers="hd_h_ml211.t3_1_1_1_1 hd_h_ml211.t3_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><b>1.20</b></td><td headers="hd_h_ml211.t3_1_1_1_1 hd_h_ml211.t3_1_1_3_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">AA69-2</td><td headers="hd_h_ml211.t3_1_1_1_1 hd_h_ml211.t3_1_1_3_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">CID 46937237</td><td headers="hd_h_ml211.t3_1_1_1_1 hd_h_ml211.t3_1_1_3_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/99445340" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">SID 99445340</a></td><td headers="hd_h_ml211.t3_1_1_1_1 hd_h_ml211.t3_1_1_3_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-02000000960-1</td><td headers="hd_h_ml211.t3_1_1_1_2 hd_h_ml211.t3_1_1_4_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><b>N2</b></td><td headers="hd_h_ml211.t3_1_1_1_2 hd_h_ml211.t3_1_1_4_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><b>4-tBu</b></td><td headers="hd_h_ml211.t3_1_1_1_2 hd_h_ml211.t3_1_1_4_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><b>CH</b></td><td headers="hd_h_ml211.t3_1_1_1_2 hd_h_ml211.t3_1_1_4_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><b>2-PrOH</b></td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_1 hd_h_ml211.t3_1_1_3_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">44</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_1 hd_h_ml211.t3_1_1_3_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">97</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_2 hd_h_ml211.t3_1_1_3_8 hd_h_ml211.t3_1_1_4_5" rowspan="1" colspan="1" style="background-color:#C4D79B;text-align:center;vertical-align:middle;">25</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_2 hd_h_ml211.t3_1_1_3_8 hd_h_ml211.t3_1_1_4_6" rowspan="1" colspan="1" style="background-color:#C4D79B;text-align:center;vertical-align:middle;">100</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_2 hd_h_ml211.t3_1_1_3_8 hd_h_ml211.t3_1_1_4_7" rowspan="1" colspan="1" style="background-color:#C4D79B;text-align:center;vertical-align:middle;">100</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_2 hd_h_ml211.t3_1_1_3_9 hd_h_ml211.t3_1_1_4_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_2 hd_h_ml211.t3_1_1_3_9 hd_h_ml211.t3_1_1_4_9" rowspan="1" colspan="1" style="background-color:#C4D79B;text-align:center;vertical-align:middle;">75</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_2 hd_h_ml211.t3_1_1_3_9 hd_h_ml211.t3_1_1_4_10" rowspan="1" colspan="1" style="background-color:#C4D79B;text-align:center;vertical-align:middle;">100</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_3 hd_h_ml211.t3_1_1_4_11" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_3 hd_h_ml211.t3_1_1_4_12" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_3 hd_h_ml211.t3_1_1_4_13" rowspan="1" colspan="1" style="background-color:#FFFF00;text-align:center;vertical-align:middle;">ABHD11</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_4 hd_h_ml211.t3_1_1_4_14" rowspan="1" colspan="1" style="background-color:#D9D9D9;text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml211.t3_1_1_1_3 hd_h_ml211.t3_1_1_2_4 hd_h_ml211.t3_1_1_4_15" rowspan="1" colspan="1" style="background-color:#C4D79B;text-align:center;vertical-align:middle;">>7</td></tr></tbody></table></div><div class="tblwrap-foot"><div><dl class="temp-labeled-list small"><dl class="bkr_refwrap"><dt>*</dt><dd><div id="ml211.tfn4"><p class="no_margin">All compounds listed are synthetic compounds.</p></div></dd></dl><dl class="bkr_refwrap"><dt>†</dt><dd><div id="ml211.tfn5"><p class="no_margin">Color scheme: green = active (inhibition data) or selective (fold selectivity data), grey = not determined (ND), yellow = ABHD11 anti-target, orange = anti-target(s) in addition to ABHD11.</p></div></dd></dl><dl class="bkr_refwrap"><dt>‡</dt><dd><div id="ml211.tfn6"><p class="no_margin">Anti-targets: alpha/beta hydrolase domain-containing protein 11 (ABHD11), esterase D/formylglutathione hydrolase (ESD), and N-acylaminoacyl-peptide hydrolase (APEH).</p></div></dd></dl><dl class="bkr_refwrap"><dt>§</dt><dd><div id="ml211.tfn7"><p class="no_margin">Fold selectivity for all other serine hydrolases (SHs) is reported as the lower of the two numbers for ESD and APEH as reported in <a href="https://pubchem.ncbi.nlm.nih.gov/bioassay/493111" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">AID 493111</a>.</p></div></dd></dl><dl class="bkr_refwrap"><dt>**</dt><dd><div id="ml211.tfn8"><p class="no_margin">Fused at 5-position of triazole; see structure of compound <b>55</b>, <a class="figpopup" href="/books/NBK133440/table/ml211.t2/?report=objectonly" target="object" rid-figpopup="figml211t2" rid-ob="figobml211t2">Table 2</a>.</p></div></dd></dl></dl></div></div></div></article><article data-type="fig" id="figobml211f2"><div id="ml211.f2" class="figure bk_fig"><div class="graphic"><img data-src="/books/NBK133440/bin/ml211f2.jpg" alt="Figure 2. Flow chart describing HTS results." /></div><h3><span class="label">Figure 2</span><span class="title">Flow chart describing HTS results</span></h3></div></article><article data-type="table-wrap" id="figobml211t2"><div id="ml211.t2" class="table"><h3><span class="label">Table 2</span><span class="title">Top Inhibitors from 2ary Screen</span></h3><div class="caption"><p>(See supplemental information for complete results.)</p></div><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK133440/table/ml211.t2/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ml211.t2_lrgtbl__"><table><thead><tr><th id="hd_h_ml211.t2_1_1_1_1" rowspan="2" colspan="1" headers="hd_h_ml211.t2_1_1_1_1" style="text-align:center;vertical-align:middle;">Compound number<br /><a class="figpopup" href="/books/NBK133440/figure/ml211.f10/?report=objectonly" target="object" rid-figpopup="figml211f10" rid-ob="figobml211f10">Figure S1</a>–<a class="figpopup" href="/books/NBK133440/figure/ml211.f12/?report=objectonly" target="object" rid-figpopup="figml211f12" rid-ob="figobml211f12">S3</a></th><th id="hd_h_ml211.t2_1_1_1_2" rowspan="2" colspan="1" headers="hd_h_ml211.t2_1_1_1_2" style="text-align:center;vertical-align:middle;">SID</th><th id="hd_h_ml211.t2_1_1_1_3" rowspan="2" colspan="1" headers="hd_h_ml211.t2_1_1_1_3" style="text-align:center;vertical-align:middle;">CID</th><th id="hd_h_ml211.t2_1_1_1_4" rowspan="2" colspan="1" headers="hd_h_ml211.t2_1_1_1_4" style="text-align:center;vertical-align:middle;">Structure</th><th id="hd_h_ml211.t2_1_1_1_5" colspan="4" rowspan="1" style="text-align:center;vertical-align:middle;">% Inhibition (20 μM)</th></tr><tr><th headers="hd_h_ml211.t2_1_1_1_5" id="hd_h_ml211.t2_1_1_2_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">rhLYPLA1</th><th headers="hd_h_ml211.t2_1_1_1_5" id="hd_h_ml211.t2_1_1_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">rhLYPLA2</th><th headers="hd_h_ml211.t2_1_1_1_5" id="hd_h_ml211.t2_1_1_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">emLYPLA1</th><th headers="hd_h_ml211.t2_1_1_1_5" id="hd_h_ml211.t2_1_1_2_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">emLYPLA2</th></tr></thead><tbody><tr><td headers="hd_h_ml211.t2_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><b>55</b></td><td headers="hd_h_ml211.t2_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/7974398" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">SID 7974398</a></td><td headers="hd_h_ml211.t2_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/bioassay/735660" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">AID 735660</a></td><td headers="hd_h_ml211.t2_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">
|
|
<div class="graphic"><img src="/books/NBK133440/bin/ml211fu4.jpg" alt="Image ml211fu4.jpg" /></div></td><td headers="hd_h_ml211.t2_1_1_1_5 hd_h_ml211.t2_1_1_2_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">98%</td><td headers="hd_h_ml211.t2_1_1_1_5 hd_h_ml211.t2_1_1_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">76%</td><td headers="hd_h_ml211.t2_1_1_1_5 hd_h_ml211.t2_1_1_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">99%</td><td headers="hd_h_ml211.t2_1_1_1_5 hd_h_ml211.t2_1_1_2_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">88%</td></tr><tr><td headers="hd_h_ml211.t2_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><b>19</b></td><td headers="hd_h_ml211.t2_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/57261525" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">SID 57261525</a></td><td headers="hd_h_ml211.t2_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/bioassay/16297767" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">AID 16297767</a></td><td headers="hd_h_ml211.t2_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">
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<div class="graphic"><img src="/books/NBK133440/bin/ml211fu5.jpg" alt="Image ml211fu5.jpg" /></div></td><td headers="hd_h_ml211.t2_1_1_1_5 hd_h_ml211.t2_1_1_2_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">70%</td><td headers="hd_h_ml211.t2_1_1_1_5 hd_h_ml211.t2_1_1_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">32%</td><td headers="hd_h_ml211.t2_1_1_1_5 hd_h_ml211.t2_1_1_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">90%</td><td headers="hd_h_ml211.t2_1_1_1_5 hd_h_ml211.t2_1_1_2_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">57%</td></tr></tbody></table></div></div></article><article data-type="fig" id="figobml211f3"><div id="ml211.f3" class="figure bk_fig"><div class="graphic"><img data-src="/books/NBK133440/bin/ml211f3.jpg" alt="Figure 3. N-Heterocyclic Urea SH Inhibitors." /></div><h3><span class="label">Figure 3</span><span class="title">N-Heterocyclic Urea SH Inhibitors</span></h3></div></article><article data-type="fig" id="figobml211f4"><div id="ml211.f4" class="figure bk_fig"><div class="graphic"><img data-src="/books/NBK133440/bin/ml211f4a.jpg" alt="Figure 4. IC50s Curves for Probe ML211 (Compound 1.18, SID 99445338) as determined by gel-based competitive-ABPP with FP-Rh (AID 493110) against targets LYPLA1 and LYPLA2." /></div><div class="graphic"><img data-src="/books/NBK133440/bin/ml211f4b.jpg" alt="Figure 4. IC50s Curves for Probe ML211 (Compound 1.18, SID 99445338) as determined by gel-based competitive-ABPP with FP-Rh (AID 493110) against targets LYPLA1 and LYPLA2." /></div><h3><span class="label">Figure 4</span><span class="title">IC<sub>50</sub>s Curves for Probe ML211 (Compound <b>1.18</b>, SID 99445338) as determined by gel-based competitive-ABPP with FP-Rh (AID 493110) against targets LYPLA1 and LYPLA2</span></h3></div></article><article data-type="fig" id="figobml211f5"><div id="ml211.f5" class="figure bk_fig"><div class="graphic"><img data-src="/books/NBK133440/bin/ml211f5.jpg" alt="Figure 5. Covalent modification of LYPLA1 by Probe ML211 (Compound 1.18, SID 99445338)." /></div><h3><span class="label">Figure 5</span><span class="title">Covalent modification of LYPLA1 by Probe <b>ML211</b> (Compound <b>1.18</b>, SID 99445338)</span></h3><div class="caption"><p>Active Site Peptide: <b>R.IILGGFS<sub>114</sub>QGGALSLYTALTTQQK.L</b></p></div></div></article><article data-type="fig" id="figobml211f6"><div id="ml211.f6" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%206.%20Potency%20and%20Selectivity%20of%2020%20Triazole%20Urea%20Synthetic%20Library%20Compounds%20at%20three%20compound%20concentrations%3A%201.5%20%003BCM%20(A)%2C%20200%20nM%20(B)%2C%20and%2030%20nM%20(C).&p=BOOKS&id=133440_ml211f6a.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img data-src="/books/NBK133440/bin/ml211f6a.jpg" alt="Figure 6. Potency and Selectivity of 20 Triazole Urea Synthetic Library Compounds at three compound concentrations: 1.5 μM (A), 200 nM (B), and 30 nM (C)." class="tileshop" title="Click on image to zoom" /></a></div><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%206.%20Potency%20and%20Selectivity%20of%2020%20Triazole%20Urea%20Synthetic%20Library%20Compounds%20at%20three%20compound%20concentrations%3A%201.5%20%003BCM%20(A)%2C%20200%20nM%20(B)%2C%20and%2030%20nM%20(C).&p=BOOKS&id=133440_ml211f6b.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img data-src="/books/NBK133440/bin/ml211f6b.jpg" alt="Figure 6. Potency and Selectivity of 20 Triazole Urea Synthetic Library Compounds at three compound concentrations: 1.5 μM (A), 200 nM (B), and 30 nM (C)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 6</span><span class="title">Potency and Selectivity of 20 Triazole Urea Synthetic Library Compounds at three compound concentrations: 1.5 μM (<b>A</b>), 200 nM (<b>B</b>), and 30 nM (<b>C</b>)</span></h3><div class="caption"><p>Gel-based competitive ABPP assay conducted as described in <a href="https://pubchem.ncbi.nlm.nih.gov/bioassay/493111" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">AID 493111</a>. Control = DMSO only (no compound). See SAR <a class="figpopup" href="/books/NBK133440/table/ml211.t2/?report=objectonly" target="object" rid-figpopup="figml211t2" rid-ob="figobml211t2">Table 2</a> for corresponding Entry/SID numbers. Observed anti-targets are alpha/beta hydrolase domain-containing protein 11 (ABHD11), esterase D/formylglutathione hydrolase (ESD), and N-acylaminoacyl-peptide hydrolase (APEH). No other FP-sensitive SH anti-targets are observed out of the 20+ visible bands. Note: AA50-1 (Compound <b>1.16</b>) appears to activate several enzymes at high (1.5 μM) concentration. Fluorescent images shown in grey scale. Gel slice at bottom of each panel shows darker scan of ABHD11 region.</p></div></div></article><article data-type="fig" id="figobml211f7"><div id="ml211.f7" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%207.%20In%20Situ%20inhibition%20of%20target%20enzymes.&p=BOOKS&id=133440_ml211f7.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img data-src="/books/NBK133440/bin/ml211f7.jpg" alt="Figure 7. In Situ inhibition of target enzymes." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 7</span><span class="title"><i>In Situ</i> inhibition of target enzymes</span></h3><div class="caption"><p><b>A.</b> Selective Inhibition of LYPLA1, LYPLA2, and ABHD11 activity by Probe <a href="/pcsubstance/?term=ML211[synonym]" ref="pagearea=body&targetsite=entrez&targetcat=term&targettype=pubchem">ML211</a> (compound <b>1.18</b>, <b>AA64-2</b>, <a href="https://pubchem.ncbi.nlm.nih.gov/substance/99445338" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">SID 99445338</a>) and Analog <b>1.20</b> (<b>AA69-2</b>, <a href="https://pubchem.ncbi.nlm.nih.gov/substance/99445340" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">SID 99445340</a>). <b>B.</b> Selective inhibition of ABHD11 by Anti-Probe <a href="/pcsubstance/?term=ML226[synonym]" ref="pagearea=body&targetsite=entrez&targetcat=term&targettype=pubchem">ML226</a> (compound <b>1.12</b>, <b>AA44-1</b>, <a href="https://pubchem.ncbi.nlm.nih.gov/substance/99445332" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">SID 99445332</a>). Assays performed with cultured BW5147-derived murine T-cells in media supplemented with 10% fetal calf serum according to <a href="https://pubchem.ncbi.nlm.nih.gov/bioassay/493108" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">AID 493108</a>. Panel at bottom shows darker scan of ABHD11 region. Fluorescent images shown in grey scale.</p></div></div></article><article data-type="fig" id="figobml211f8"><div id="ml211.f8" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%208.%20Cytotoxicity%20of%20probe%20and%20probe%20analogs%20in%20serum-free%20(A)%20and%20serum-supplemented%20(B)%20media.&p=BOOKS&id=133440_ml211f8.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img data-src="/books/NBK133440/bin/ml211f8.jpg" alt="Figure 8. Cytotoxicity of probe and probe analogs in serum-free (A) and serum-supplemented (B) media." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 8</span><span class="title">Cytotoxicity of probe and probe analogs in serum-free (<b>A</b>) and serum-supplemented (<b>B</b>) media</span></h3><div class="caption"><p>See <a href="https://pubchem.ncbi.nlm.nih.gov/bioassay/493161" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">AID 493161</a> for details.</p></div><div class="iconblock whole_rhythm clearfix ten_col table-wrap" id="figml211tu2"><a href="/books/NBK133440/table/ml211.tu2/?report=objectonly" target="object" title="Table" class="img_link icnblk_img figpopup" rid-figpopup="figml211tu2" rid-ob="figobml211tu2"><img class="small-thumb" src="/books/NBK133440/table/ml211.tu2/?report=thumb" src-large="/books/NBK133440/table/ml211.tu2/?report=previmg" alt="Outcome." /></a><div class="icnblk_cntnt"><h4 id="ml211.tu2"><a href="/books/NBK133440/table/ml211.tu2/?report=objectonly" target="object" rid-ob="figobml211tu2">Table</a></h4><p class="float-caption no_bottom_margin">Outcome. </p></div></div></div></article><article data-type="table-wrap" id="figobml211tu2"><div id="ml211.tu2" class="table"><h3><span class="title">Outcome</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK133440/table/ml211.tu2/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ml211.tu2_lrgtbl__"><table class="no_top_margin"><thead><tr><th id="hd_h_ml211.tu2_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Compound</th><th id="hd_h_ml211.tu2_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">CC50 (serum free)</th><th id="hd_h_ml211.tu2_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">CC50 (serum supplemented)</th></tr></thead><tbody><tr><td headers="hd_h_ml211.tu2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Probe <a href="/pcsubstance/?term=ML211[synonym]" ref="pagearea=body&targetsite=entrez&targetcat=term&targettype=pubchem">ML211</a> (1.18)</td><td headers="hd_h_ml211.tu2_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"> >35</td><td headers="hd_h_ml211.tu2_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"> >50</td></tr><tr><td headers="hd_h_ml211.tu2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Analog 1.20</td><td headers="hd_h_ml211.tu2_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"> >9</td><td headers="hd_h_ml211.tu2_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"> >27</td></tr><tr><td headers="hd_h_ml211.tu2_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Anti-Probe <a href="/pcsubstance/?term=ML226[synonym]" ref="pagearea=body&targetsite=entrez&targetcat=term&targettype=pubchem">ML226</a> ( 1.12)</td><td headers="hd_h_ml211.tu2_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"> >50</td><td headers="hd_h_ml211.tu2_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"> >50</td></tr></tbody></table></div></div></article><article data-type="fig" id="figobml211f9"><div id="ml211.f9" class="figure bk_fig"><div class="graphic"><img data-src="/books/NBK133440/bin/ml211f9.jpg" alt="Figure 9. Structures of existing LYPLA1-inhibitors." /></div><h3><span class="label">Figure 9</span><span class="title">Structures of existing LYPLA1-inhibitors</span></h3></div></article><article data-type="fig" id="figobml211f10"><div id="ml211.f10" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%20S1.%20First%20Round%20Secondary%20Screening%3A%20Competitive-ABPP%20profiling%20with%20recombinant%20LYPLA1%20(human)%20and%20endogenous%20LYPLA1%20and%20LYPLA2%20(mouse%20brain%20soluble%20proteome)%3A%2020%20%003BCM%20Test%20Compound.&p=BOOKS&id=133440_ml211f10a.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img data-src="/books/NBK133440/bin/ml211f10a.jpg" alt="Figure S1. First Round Secondary Screening: Competitive-ABPP profiling with recombinant LYPLA1 (human) and endogenous LYPLA1 and LYPLA2 (mouse brain soluble proteome): 20 μM Test Compound." class="tileshop" title="Click on image to zoom" /></a></div><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%20S1.%20First%20Round%20Secondary%20Screening%3A%20Competitive-ABPP%20profiling%20with%20recombinant%20LYPLA1%20(human)%20and%20endogenous%20LYPLA1%20and%20LYPLA2%20(mouse%20brain%20soluble%20proteome)%3A%2020%20%003BCM%20Test%20Compound.&p=BOOKS&id=133440_ml211f10b.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img data-src="/books/NBK133440/bin/ml211f10b.jpg" alt="Figure S1. First Round Secondary Screening: Competitive-ABPP profiling with recombinant LYPLA1 (human) and endogenous LYPLA1 and LYPLA2 (mouse brain soluble proteome): 20 μM Test Compound." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure S1</span><span class="title">First Round Secondary Screening: Competitive-ABPP profiling with recombinant LYPLA1 (human) and endogenous LYPLA1 and LYPLA2 (mouse brain soluble proteome): 20 μM Test Compound</span></h3><div class="caption"><p>Quantification of rhLYPLA1 inhibition in <a href="https://pubchem.ncbi.nlm.nih.gov/bioassay/493105" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">AID 493105</a>; 20 nM recombinant human LYPLA1 doped into 1 mg/mL mouse brain soluble proteome; 20 μM inhibitor treatment for 30 min followed by FP-Rh labeling for 30 min, SDS-PAGE and in-gel fluorescent imaging. See <a class="figpopup" href="/books/NBK133440/table/ml211.t4/?report=objectonly" target="object" rid-figpopup="figml211t4" rid-ob="figobml211t4">Table S1</a> for compound SIDs and structures.</p></div></div></article><article data-type="fig" id="figobml211f11"><div id="ml211.f11" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%20S2.%20Second%20Round%20Secondary%20Screening%3A%20Competitive-ABPP%20profiling%20with%20recombinant%20LYPLA2%20(human)%20and%20endogenous%20LYPLA1%20and%20LYPLA2%20(mouse%20brain%20membrane%20proteome)%3A%2020%20%003BCM%20Test%20Compound.&p=BOOKS&id=133440_ml211f11a.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img data-src="/books/NBK133440/bin/ml211f11a.jpg" alt="Figure S2. Second Round Secondary Screening: Competitive-ABPP profiling with recombinant LYPLA2 (human) and endogenous LYPLA1 and LYPLA2 (mouse brain membrane proteome): 20 μM Test Compound." class="tileshop" title="Click on image to zoom" /></a></div><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%20S2.%20Second%20Round%20Secondary%20Screening%3A%20Competitive-ABPP%20profiling%20with%20recombinant%20LYPLA2%20(human)%20and%20endogenous%20LYPLA1%20and%20LYPLA2%20(mouse%20brain%20membrane%20proteome)%3A%2020%20%003BCM%20Test%20Compound.&p=BOOKS&id=133440_ml211f11b.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img data-src="/books/NBK133440/bin/ml211f11b.jpg" alt="Figure S2. Second Round Secondary Screening: Competitive-ABPP profiling with recombinant LYPLA2 (human) and endogenous LYPLA1 and LYPLA2 (mouse brain membrane proteome): 20 μM Test Compound." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure S2</span><span class="title">Second Round Secondary Screening: Competitive-ABPP profiling with recombinant LYPLA2 (human) and endogenous LYPLA1 and LYPLA2 (mouse brain membrane proteome): 20 μM Test Compound</span></h3><div class="caption"><p>Quantification of rhLYPLA2 and endogenous LYPLA1 and LYPLA2 inhibition in <a href="https://pubchem.ncbi.nlm.nih.gov/bioassay/493105" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">AID 493105</a> (note: endogenous LYPLA1 not quantified for compounds 4–19 (A) or 28–41 (B) due to smearing of band; 20 nM recombinant human LYPLA2 doped into 1 mg/mL mouse brain membrane proteome; 20 μM inhibitor treatment for 30 min followed by FP-Rh labeling for 30 min, SDS-PAGE and in-gel fluorescent imaging. See <a class="figpopup" href="/books/NBK133440/table/ml211.t4/?report=objectonly" target="object" rid-figpopup="figml211t4" rid-ob="figobml211t4">Table S1</a> for compound SIDs and structures.</p></div></div></article><article data-type="fig" id="figobml211f12"><div id="ml211.f12" class="figure bk_fig"><div class="graphic"><img data-src="/books/NBK133440/bin/ml211f12.jpg" alt="Figure S3. Second Round Secondary Screening: Additional gel of competitive-ABPP profiling with select compounds for quantification of endogenous LYPLA1 (mouse brain membrane proteome)." /></div><h3><span class="label">Figure S3</span><span class="title">Second Round Secondary Screening: Additional gel of competitive-ABPP profiling with select compounds for quantification of endogenous LYPLA1 (mouse brain membrane proteome)</span></h3><div class="caption"><p>Quantification of endogenous LYPLA1 inhibition in <a href="https://pubchem.ncbi.nlm.nih.gov/bioassay/493105" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">AID 493105</a>; 20 nM recombinant human LYPLA1 doped into 1 mg/mL mouse brain membrane proteome; 20 μM inhibitor treatment for 30 min followed by FP-Rh labeling for 30 min, SDS-PAGE and in-gel fluorescent imaging. See <a class="figpopup" href="/books/NBK133440/table/ml211.t4/?report=objectonly" target="object" rid-figpopup="figml211t4" rid-ob="figobml211t4">Table S1</a> for compound SIDs and structures.</p></div></div></article><article data-type="table-wrap" id="figobml211t4"><div id="ml211.t4" class="table"><h3><span class="label">Table S1</span><span class="title">Compounds tested by Secondary Screening (AID 493105)</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK133440/table/ml211.t4/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ml211.t4_lrgtbl__"><table class="no_margin"><thead><tr><th id="hd_h_ml211.t4_1_1_1_1" rowspan="2" colspan="1" headers="hd_h_ml211.t4_1_1_1_1" style="text-align:center;vertical-align:middle;">Cpd #</th><th id="hd_h_ml211.t4_1_1_1_2" rowspan="2" colspan="1" headers="hd_h_ml211.t4_1_1_1_2" style="text-align:center;vertical-align:middle;">SID</th><th id="hd_h_ml211.t4_1_1_1_3" rowspan="2" colspan="1" headers="hd_h_ml211.t4_1_1_1_3" style="text-align:center;vertical-align:middle;">SRID</th><th id="hd_h_ml211.t4_1_1_1_4" rowspan="2" colspan="1" headers="hd_h_ml211.t4_1_1_1_4" style="text-align:center;vertical-align:middle;">Structure</th><th id="hd_h_ml211.t4_1_1_1_5" colspan="4" rowspan="1" style="text-align:center;vertical-align:middle;">% Inhibition</th></tr><tr><th headers="hd_h_ml211.t4_1_1_1_5" id="hd_h_ml211.t4_1_1_2_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">rhLYPLA1</th><th headers="hd_h_ml211.t4_1_1_1_5" id="hd_h_ml211.t4_1_1_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">rhLYPLA2</th><th headers="hd_h_ml211.t4_1_1_1_5" id="hd_h_ml211.t4_1_1_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">emLYPLA1</th><th headers="hd_h_ml211.t4_1_1_1_5" id="hd_h_ml211.t4_1_1_2_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">emLYPLA2</th></tr></thead><tbody><tr><td headers="hd_h_ml211.t4_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">1</td><td headers="hd_h_ml211.t4_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/49716909" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">SID 49716909</a></td><td headers="hd_h_ml211.t4_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-01000827909-1</td><td headers="hd_h_ml211.t4_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">
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<div class="graphic"><img src="/books/NBK133440/bin/ml211fu6.jpg" alt="Image ml211fu6.jpg" /></div></td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">1%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">5%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0%</td></tr><tr><td headers="hd_h_ml211.t4_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">2</td><td headers="hd_h_ml211.t4_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/858986" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">SID 858986</a></td><td headers="hd_h_ml211.t4_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-01000611999-1</td><td headers="hd_h_ml211.t4_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">
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<div class="graphic"><img src="/books/NBK133440/bin/ml211fu7.jpg" alt="Image ml211fu7.jpg" /></div></td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">3%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">11%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">10%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">16%</td></tr><tr><td headers="hd_h_ml211.t4_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">3</td><td headers="hd_h_ml211.t4_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/17414171" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">SID 17414171</a></td><td headers="hd_h_ml211.t4_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-01000271652-2</td><td headers="hd_h_ml211.t4_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">
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<div class="graphic"><img src="/books/NBK133440/bin/ml211fu8.jpg" alt="Image ml211fu8.jpg" /></div></td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">5%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">8%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">6%</td></tr><tr><td headers="hd_h_ml211.t4_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">4</td><td headers="hd_h_ml211.t4_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/49715467" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">SID 49715467</a></td><td headers="hd_h_ml211.t4_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-01000544381-2</td><td headers="hd_h_ml211.t4_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">
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<div class="graphic"><img src="/books/NBK133440/bin/ml211fu9.jpg" alt="Image ml211fu9.jpg" /></div></td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_2" rowspan="1" colspan="1" style="background-color:#66FF33;text-align:center;vertical-align:middle;">61%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">16%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_4" rowspan="1" colspan="1" style="background-color:#66FF33;text-align:center;vertical-align:middle;">83%</td></tr><tr><td headers="hd_h_ml211.t4_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">5</td><td headers="hd_h_ml211.t4_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/49640730" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">SID 49640730</a></td><td headers="hd_h_ml211.t4_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-01000454606-2</td><td headers="hd_h_ml211.t4_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">
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<div class="graphic"><img src="/books/NBK133440/bin/ml211fu10.jpg" alt="Image ml211fu10.jpg" /></div></td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">2%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_2" rowspan="1" colspan="1" style="background-color:#66FF33;text-align:center;vertical-align:middle;">34%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_3" rowspan="1" colspan="1" style="background-color:#D9D9D9;text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_4" rowspan="1" colspan="1" style="background-color:#66FF33;text-align:center;vertical-align:middle;">52%</td></tr><tr><td headers="hd_h_ml211.t4_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">6</td><td headers="hd_h_ml211.t4_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/49818888" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">SID 49818888</a></td><td headers="hd_h_ml211.t4_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-01000169222-2</td><td headers="hd_h_ml211.t4_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">
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<div class="graphic"><img src="/books/NBK133440/bin/ml211fu11.jpg" alt="Image ml211fu11.jpg" /></div></td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_3" rowspan="1" colspan="1" style="background-color:#D9D9D9;text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0%</td></tr><tr><td headers="hd_h_ml211.t4_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">7</td><td headers="hd_h_ml211.t4_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/26659987" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">SID 26659987</a></td><td headers="hd_h_ml211.t4_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-01000012688-2</td><td headers="hd_h_ml211.t4_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">
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<div class="graphic"><img src="/books/NBK133440/bin/ml211fu12.jpg" alt="Image ml211fu12.jpg" /></div></td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">2%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">4%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0%</td></tr><tr><td headers="hd_h_ml211.t4_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">8</td><td headers="hd_h_ml211.t4_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/49723891" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">SID 49723891</a></td><td headers="hd_h_ml211.t4_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-01000797542-1</td><td headers="hd_h_ml211.t4_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">
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<div class="graphic"><img src="/books/NBK133440/bin/ml211fu13.jpg" alt="Image ml211fu13.jpg" /></div></td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">12%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_3" rowspan="1" colspan="1" style="background-color:#D9D9D9;text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0%</td></tr><tr><td headers="hd_h_ml211.t4_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">9</td><td headers="hd_h_ml211.t4_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/848791" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">SID 848791</a></td><td headers="hd_h_ml211.t4_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-01000602019-1</td><td headers="hd_h_ml211.t4_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">
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<div class="graphic"><img src="/books/NBK133440/bin/ml211fu14.jpg" alt="Image ml211fu14.jpg" /></div></td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_1" rowspan="1" colspan="1" style="background-color:#66FF33;text-align:center;vertical-align:middle;">43%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">3%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">14%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">14%</td></tr><tr><td headers="hd_h_ml211.t4_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">10</td><td headers="hd_h_ml211.t4_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/24810381" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">SID 24810381</a></td><td headers="hd_h_ml211.t4_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-01000544853-2</td><td headers="hd_h_ml211.t4_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">
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<div class="graphic"><img src="/books/NBK133440/bin/ml211fu15.jpg" alt="Image ml211fu15.jpg" /></div></td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_1" rowspan="1" colspan="1" style="background-color:#66FF33;text-align:center;vertical-align:middle;">35%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_2" rowspan="1" colspan="1" style="background-color:#66FF33;text-align:center;vertical-align:middle;">50%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">8%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_4" rowspan="1" colspan="1" style="background-color:#66FF33;text-align:center;vertical-align:middle;">68%</td></tr><tr><td headers="hd_h_ml211.t4_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">11</td><td headers="hd_h_ml211.t4_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/4241065" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">SID 4241065</a></td><td headers="hd_h_ml211.t4_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-01000594845-2</td><td headers="hd_h_ml211.t4_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">
|
|
<div class="graphic"><img src="/books/NBK133440/bin/ml211fu16.jpg" alt="Image ml211fu16.jpg" /></div></td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_1" rowspan="1" colspan="1" style="background-color:#66FF33;text-align:center;vertical-align:middle;">36%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">6%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">9%</td></tr><tr><td headers="hd_h_ml211.t4_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">12</td><td headers="hd_h_ml211.t4_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/24810537" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">SID 24810537</a></td><td headers="hd_h_ml211.t4_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-01000727685-1</td><td headers="hd_h_ml211.t4_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">
|
|
<div class="graphic"><img src="/books/NBK133440/bin/ml211fu17.jpg" alt="Image ml211fu17.jpg" /></div></td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">6%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_3" rowspan="1" colspan="1" style="background-color:#D9D9D9;text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">6%</td></tr><tr><td headers="hd_h_ml211.t4_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">13</td><td headers="hd_h_ml211.t4_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/57265423" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">SID 57265423</a></td><td headers="hd_h_ml211.t4_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-01000858669-1</td><td headers="hd_h_ml211.t4_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">
|
|
<div class="graphic"><img src="/books/NBK133440/bin/ml211fu18.jpg" alt="Image ml211fu18.jpg" /></div></td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">20%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">5%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">12%</td></tr><tr><td headers="hd_h_ml211.t4_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">14</td><td headers="hd_h_ml211.t4_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/24830735" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">SID 24830735</a></td><td headers="hd_h_ml211.t4_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-01000730037-1</td><td headers="hd_h_ml211.t4_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">
|
|
<div class="graphic"><img src="/books/NBK133440/bin/ml211fu19.jpg" alt="Image ml211fu19.jpg" /></div></td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">27%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">10%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">26%</td></tr><tr><td headers="hd_h_ml211.t4_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">15</td><td headers="hd_h_ml211.t4_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/17506896" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">SID 17506896</a></td><td headers="hd_h_ml211.t4_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-01000700450-1</td><td headers="hd_h_ml211.t4_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">
|
|
<div class="graphic"><img src="/books/NBK133440/bin/ml211fu20.jpg" alt="Image ml211fu20.jpg" /></div></td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_1" rowspan="1" colspan="1" style="background-color:#66FF33;text-align:center;vertical-align:middle;">47%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">3%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0%</td></tr><tr><td headers="hd_h_ml211.t4_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">16</td><td headers="hd_h_ml211.t4_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/17506722" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">SID 17506722</a></td><td headers="hd_h_ml211.t4_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-01000695733-1</td><td headers="hd_h_ml211.t4_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">
|
|
<div class="graphic"><img src="/books/NBK133440/bin/ml211fu21.jpg" alt="Image ml211fu21.jpg" /></div></td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_1" rowspan="1" colspan="1" style="background-color:#66FF33;text-align:center;vertical-align:middle;">45%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">7%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">3%</td></tr><tr><td headers="hd_h_ml211.t4_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">17</td><td headers="hd_h_ml211.t4_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/17412845" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">SID 17412845</a></td><td headers="hd_h_ml211.t4_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-01000682982-1</td><td headers="hd_h_ml211.t4_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">
|
|
<div class="graphic"><img src="/books/NBK133440/bin/ml211fu22.jpg" alt="Image ml211fu22.jpg" /></div></td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">5%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_3" rowspan="1" colspan="1" style="background-color:#D9D9D9;text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0%</td></tr><tr><td headers="hd_h_ml211.t4_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">18</td><td headers="hd_h_ml211.t4_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/26664181" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">SID 26664181</a></td><td headers="hd_h_ml211.t4_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-01000773291-1</td><td headers="hd_h_ml211.t4_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">
|
|
<div class="graphic"><img src="/books/NBK133440/bin/ml211fu23.jpg" alt="Image ml211fu23.jpg" /></div></td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">2%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">5%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_3" rowspan="1" colspan="1" style="background-color:#D9D9D9;text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">1%</td></tr><tr><td headers="hd_h_ml211.t4_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">19</td><td headers="hd_h_ml211.t4_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/57261525" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">SID 57261525</a></td><td headers="hd_h_ml211.t4_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-01000854272-1</td><td headers="hd_h_ml211.t4_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">
|
|
<div class="graphic"><img src="/books/NBK133440/bin/ml211fu24.jpg" alt="Image ml211fu24.jpg" /></div></td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_1" rowspan="1" colspan="1" style="background-color:#66FF33;text-align:center;vertical-align:middle;">70%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_2" rowspan="1" colspan="1" style="background-color:#66FF33;text-align:center;vertical-align:middle;">32%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_3" rowspan="1" colspan="1" style="background-color:#66FF33;text-align:center;vertical-align:middle;">90%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_4" rowspan="1" colspan="1" style="background-color:#66FF33;text-align:center;vertical-align:middle;">57%</td></tr><tr><td headers="hd_h_ml211.t4_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">20</td><td headers="hd_h_ml211.t4_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/49715550" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">SID 49715550</a></td><td headers="hd_h_ml211.t4_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-01000544841-2</td><td headers="hd_h_ml211.t4_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">
|
|
<div class="graphic"><img src="/books/NBK133440/bin/ml211fu25.jpg" alt="Image ml211fu25.jpg" /></div></td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">16%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">7%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">23%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">15%</td></tr><tr><td headers="hd_h_ml211.t4_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">21</td><td headers="hd_h_ml211.t4_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/57255928" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">SID 57255928</a></td><td headers="hd_h_ml211.t4_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-01000863156-1</td><td headers="hd_h_ml211.t4_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">
|
|
<div class="graphic"><img src="/books/NBK133440/bin/ml211fu26.jpg" alt="Image ml211fu26.jpg" /></div></td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">2%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">13%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0%</td></tr><tr><td headers="hd_h_ml211.t4_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">22</td><td headers="hd_h_ml211.t4_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/17414052" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">SID 17414052</a></td><td headers="hd_h_ml211.t4_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-01000679356-1</td><td headers="hd_h_ml211.t4_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">
|
|
<div class="graphic"><img src="/books/NBK133440/bin/ml211fu27.jpg" alt="Image ml211fu27.jpg" /></div></td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_1" rowspan="1" colspan="1" style="background-color:#66FF33;text-align:center;vertical-align:middle;">47%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_2" rowspan="1" colspan="1" style="background-color:#66FF33;text-align:center;vertical-align:middle;">41%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_3" rowspan="1" colspan="1" style="background-color:#66FF33;text-align:center;vertical-align:middle;">50%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_4" rowspan="1" colspan="1" style="background-color:#66FF33;text-align:center;vertical-align:middle;">66%</td></tr><tr><td headers="hd_h_ml211.t4_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">23</td><td headers="hd_h_ml211.t4_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/26670599" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">SID 26670599</a></td><td headers="hd_h_ml211.t4_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-01000624528-2</td><td headers="hd_h_ml211.t4_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">
|
|
<div class="graphic"><img src="/books/NBK133440/bin/ml211fu28.jpg" alt="Image ml211fu28.jpg" /></div></td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">27%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">7%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">2%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">3%</td></tr><tr><td headers="hd_h_ml211.t4_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">24</td><td headers="hd_h_ml211.t4_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/3712341" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">SID 3712341</a></td><td headers="hd_h_ml211.t4_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-01000054909-2</td><td headers="hd_h_ml211.t4_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">
|
|
<div class="graphic"><img src="/books/NBK133440/bin/ml211fu29.jpg" alt="Image ml211fu29.jpg" /></div></td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">8%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">19%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">17%</td></tr><tr><td headers="hd_h_ml211.t4_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">25</td><td headers="hd_h_ml211.t4_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/49666417" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">SID 49666417</a></td><td headers="hd_h_ml211.t4_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-01000815646-1</td><td headers="hd_h_ml211.t4_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">
|
|
<div class="graphic"><img src="/books/NBK133440/bin/ml211fu30.jpg" alt="Image ml211fu30.jpg" /></div></td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">6%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">9%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">1%</td></tr><tr><td headers="hd_h_ml211.t4_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">26</td><td headers="hd_h_ml211.t4_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/24823520" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">SID 24823520</a></td><td headers="hd_h_ml211.t4_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-01000743033-1</td><td headers="hd_h_ml211.t4_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">
|
|
<div class="graphic"><img src="/books/NBK133440/bin/ml211fu31.jpg" alt="Image ml211fu31.jpg" /></div></td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">3%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">2%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">5%</td></tr><tr><td headers="hd_h_ml211.t4_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">27</td><td headers="hd_h_ml211.t4_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/24781868" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">SID 24781868</a></td><td headers="hd_h_ml211.t4_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-01000543175-2</td><td headers="hd_h_ml211.t4_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">
|
|
<div class="graphic"><img src="/books/NBK133440/bin/ml211fu32.jpg" alt="Image ml211fu32.jpg" /></div></td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_2" rowspan="1" colspan="1" style="background-color:#66FF33;text-align:center;vertical-align:middle;">39%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">1%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_4" rowspan="1" colspan="1" style="background-color:#66FF33;text-align:center;vertical-align:middle;">52%</td></tr><tr><td headers="hd_h_ml211.t4_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">28</td><td headers="hd_h_ml211.t4_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/17509033" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">SID 17509033</a></td><td headers="hd_h_ml211.t4_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-01000704342-1</td><td headers="hd_h_ml211.t4_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">
|
|
<div class="graphic"><img src="/books/NBK133440/bin/ml211fu33.jpg" alt="Image ml211fu33.jpg" /></div></td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">7%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">5%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_3" rowspan="1" colspan="1" style="background-color:#D9D9D9;text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">1%</td></tr><tr><td headers="hd_h_ml211.t4_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">29</td><td headers="hd_h_ml211.t4_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/17507150" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">SID 17507150</a></td><td headers="hd_h_ml211.t4_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-01000702194-1</td><td headers="hd_h_ml211.t4_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">
|
|
<div class="graphic"><img src="/books/NBK133440/bin/ml211fu34.jpg" alt="Image ml211fu34.jpg" /></div></td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">15%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">18%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_3" rowspan="1" colspan="1" style="background-color:#D9D9D9;text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_4" rowspan="1" colspan="1" style="background-color:#66FF33;text-align:center;vertical-align:middle;">34%</td></tr><tr><td headers="hd_h_ml211.t4_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">30</td><td headers="hd_h_ml211.t4_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/22402087" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">SID 22402087</a></td><td headers="hd_h_ml211.t4_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-01000718507-1</td><td headers="hd_h_ml211.t4_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">
|
|
<div class="graphic"><img src="/books/NBK133440/bin/ml211fu35.jpg" alt="Image ml211fu35.jpg" /></div></td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">17%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">5%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_3" rowspan="1" colspan="1" style="background-color:#D9D9D9;text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">16%</td></tr><tr><td headers="hd_h_ml211.t4_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">31</td><td headers="hd_h_ml211.t4_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/49818988" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">SID 49818988</a></td><td headers="hd_h_ml211.t4_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-01000797695-1</td><td headers="hd_h_ml211.t4_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">
|
|
<div class="graphic"><img src="/books/NBK133440/bin/ml211fu36.jpg" alt="Image ml211fu36.jpg" /></div></td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">3%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_3" rowspan="1" colspan="1" style="background-color:#D9D9D9;text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">5%</td></tr><tr><td headers="hd_h_ml211.t4_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">32</td><td headers="hd_h_ml211.t4_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/49732220" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">SID 49732220</a></td><td headers="hd_h_ml211.t4_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-01000828625-1</td><td headers="hd_h_ml211.t4_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">
|
|
<div class="graphic"><img src="/books/NBK133440/bin/ml211fu37.jpg" alt="Image ml211fu37.jpg" /></div></td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">6%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_3" rowspan="1" colspan="1" style="background-color:#D9D9D9;text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">16%</td></tr><tr><td headers="hd_h_ml211.t4_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">33</td><td headers="hd_h_ml211.t4_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/50086851" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">SID 50086851</a></td><td headers="hd_h_ml211.t4_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-01000799140-1</td><td headers="hd_h_ml211.t4_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">
|
|
<div class="graphic"><img src="/books/NBK133440/bin/ml211fu38.jpg" alt="Image ml211fu38.jpg" /></div></td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">13%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">28%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_3" rowspan="1" colspan="1" style="background-color:#D9D9D9;text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_4" rowspan="1" colspan="1" style="background-color:#66FF33;text-align:center;vertical-align:middle;">42%</td></tr><tr><td headers="hd_h_ml211.t4_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">34</td><td headers="hd_h_ml211.t4_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/49715375" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">SID 49715375</a></td><td headers="hd_h_ml211.t4_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-01000546954-2</td><td headers="hd_h_ml211.t4_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">
|
|
<div class="graphic"><img src="/books/NBK133440/bin/ml211fu39.jpg" alt="Image ml211fu39.jpg" /></div></td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">17%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">17%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_3" rowspan="1" colspan="1" style="background-color:#D9D9D9;text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_4" rowspan="1" colspan="1" style="background-color:#66FF33;text-align:center;vertical-align:middle;">43%</td></tr><tr><td headers="hd_h_ml211.t4_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">35</td><td headers="hd_h_ml211.t4_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/24786177" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">SID 24786177</a></td><td headers="hd_h_ml211.t4_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-01000756883-1</td><td headers="hd_h_ml211.t4_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">
|
|
<div class="graphic"><img src="/books/NBK133440/bin/ml211fu40.jpg" alt="Image ml211fu40.jpg" /></div></td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">6%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_3" rowspan="1" colspan="1" style="background-color:#D9D9D9;text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">12%</td></tr><tr><td headers="hd_h_ml211.t4_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">36</td><td headers="hd_h_ml211.t4_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/17413803" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">SID 17413803</a></td><td headers="hd_h_ml211.t4_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-01000691648-1</td><td headers="hd_h_ml211.t4_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">
|
|
<div class="graphic"><img src="/books/NBK133440/bin/ml211fu41.jpg" alt="Image ml211fu41.jpg" /></div></td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_1" rowspan="1" colspan="1" style="background-color:#66FF33;text-align:center;vertical-align:middle;">36%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">5%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_3" rowspan="1" colspan="1" style="background-color:#D9D9D9;text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">10%</td></tr><tr><td headers="hd_h_ml211.t4_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">37</td><td headers="hd_h_ml211.t4_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/49678332" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">SID 49678332</a></td><td headers="hd_h_ml211.t4_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-01000053974-2</td><td headers="hd_h_ml211.t4_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">
|
|
<div class="graphic"><img src="/books/NBK133440/bin/ml211fu42.jpg" alt="Image ml211fu42.jpg" /></div></td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">4%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_3" rowspan="1" colspan="1" style="background-color:#D9D9D9;text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">6%</td></tr><tr><td headers="hd_h_ml211.t4_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">38</td><td headers="hd_h_ml211.t4_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/14746269" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">SID 14746269</a></td><td headers="hd_h_ml211.t4_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-01000665892-1</td><td headers="hd_h_ml211.t4_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">
|
|
<div class="graphic"><img src="/books/NBK133440/bin/ml211fu43.jpg" alt="Image ml211fu43.jpg" /></div></td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">12%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_3" rowspan="1" colspan="1" style="background-color:#D9D9D9;text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">25%</td></tr><tr><td headers="hd_h_ml211.t4_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">39</td><td headers="hd_h_ml211.t4_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/3715194" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">SID 3715194</a></td><td headers="hd_h_ml211.t4_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-01000614839-1</td><td headers="hd_h_ml211.t4_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">
|
|
<div class="graphic"><img src="/books/NBK133440/bin/ml211fu44.jpg" alt="Image ml211fu44.jpg" /></div></td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">3%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_3" rowspan="1" colspan="1" style="background-color:#D9D9D9;text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">2%</td></tr><tr><td headers="hd_h_ml211.t4_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">40</td><td headers="hd_h_ml211.t4_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/24837183" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">SID 24837183</a></td><td headers="hd_h_ml211.t4_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-01000744209-1</td><td headers="hd_h_ml211.t4_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">
|
|
<div class="graphic"><img src="/books/NBK133440/bin/ml211fu45.jpg" alt="Image ml211fu45.jpg" /></div></td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">11%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">20%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_3" rowspan="1" colspan="1" style="background-color:#D9D9D9;text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">27%</td></tr><tr><td headers="hd_h_ml211.t4_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">41</td><td headers="hd_h_ml211.t4_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/17432895" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">SID 17432895</a></td><td headers="hd_h_ml211.t4_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-01000699977-1</td><td headers="hd_h_ml211.t4_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">
|
|
<div class="graphic"><img src="/books/NBK133440/bin/ml211fu46.jpg" alt="Image ml211fu46.jpg" /></div></td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">16%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">15%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_3" rowspan="1" colspan="1" style="background-color:#D9D9D9;text-align:center;vertical-align:middle;">ND</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">16%</td></tr><tr><td headers="hd_h_ml211.t4_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">42</td><td headers="hd_h_ml211.t4_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/4263443" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">SID 4263443</a></td><td headers="hd_h_ml211.t4_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-01000557611-2</td><td headers="hd_h_ml211.t4_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">
|
|
<div class="graphic"><img src="/books/NBK133440/bin/ml211fu47.jpg" alt="Image ml211fu47.jpg" /></div></td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">13%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">8%</td></tr><tr><td headers="hd_h_ml211.t4_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">43</td><td headers="hd_h_ml211.t4_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/49677725" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">SID 49677725</a></td><td headers="hd_h_ml211.t4_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-01000017967-2</td><td headers="hd_h_ml211.t4_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">
|
|
<div class="graphic"><img src="/books/NBK133440/bin/ml211fu48.jpg" alt="Image ml211fu48.jpg" /></div></td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">3%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0%</td></tr><tr><td headers="hd_h_ml211.t4_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">44</td><td headers="hd_h_ml211.t4_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/56463282" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">SID 56463282</a></td><td headers="hd_h_ml211.t4_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-01000075486-4</td><td headers="hd_h_ml211.t4_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">
|
|
<div class="graphic"><img src="/books/NBK133440/bin/ml211fu49.jpg" alt="Image ml211fu49.jpg" /></div></td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0%</td></tr><tr><td headers="hd_h_ml211.t4_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">45</td><td headers="hd_h_ml211.t4_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/24802989" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">SID 24802989</a></td><td headers="hd_h_ml211.t4_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-01000731944-1</td><td headers="hd_h_ml211.t4_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">
|
|
<div class="graphic"><img src="/books/NBK133440/bin/ml211fu50.jpg" alt="Image ml211fu50.jpg" /></div></td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">26%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">3%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0%</td></tr><tr><td headers="hd_h_ml211.t4_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">46</td><td headers="hd_h_ml211.t4_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/17416154" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">SID 17416154</a></td><td headers="hd_h_ml211.t4_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-01000446277-2</td><td headers="hd_h_ml211.t4_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">
|
|
<div class="graphic"><img src="/books/NBK133440/bin/ml211fu51.jpg" alt="Image ml211fu51.jpg" /></div></td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">9%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">16%</td></tr><tr><td headers="hd_h_ml211.t4_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">47</td><td headers="hd_h_ml211.t4_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/24781867" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">SID 24781867</a></td><td headers="hd_h_ml211.t4_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-01000543180-2</td><td headers="hd_h_ml211.t4_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">
|
|
<div class="graphic"><img src="/books/NBK133440/bin/ml211fu52.jpg" alt="Image ml211fu52.jpg" /></div></td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">26%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">15%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_4" rowspan="1" colspan="1" style="background-color:#66FF33;text-align:center;vertical-align:middle;">34%</td></tr><tr><td headers="hd_h_ml211.t4_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">48</td><td headers="hd_h_ml211.t4_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/24830059" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">SID 24830059</a></td><td headers="hd_h_ml211.t4_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-01000728507-1</td><td headers="hd_h_ml211.t4_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">
|
|
<div class="graphic"><img src="/books/NBK133440/bin/ml211fu53.jpg" alt="Image ml211fu53.jpg" /></div></td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">29%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">12%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0%</td></tr><tr><td headers="hd_h_ml211.t4_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">49</td><td headers="hd_h_ml211.t4_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/26664628" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">SID 26664628</a></td><td headers="hd_h_ml211.t4_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-01000772597-1</td><td headers="hd_h_ml211.t4_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">
|
|
<div class="graphic"><img src="/books/NBK133440/bin/ml211fu54.jpg" alt="Image ml211fu54.jpg" /></div></td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0%</td></tr><tr><td headers="hd_h_ml211.t4_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">50</td><td headers="hd_h_ml211.t4_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/57264872" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">SID 57264872</a></td><td headers="hd_h_ml211.t4_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-01000855692-1</td><td headers="hd_h_ml211.t4_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">
|
|
<div class="graphic"><img src="/books/NBK133440/bin/ml211fu55.jpg" alt="Image ml211fu55.jpg" /></div></td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_1" rowspan="1" colspan="1" style="background-color:#66FF33;text-align:center;vertical-align:middle;">55%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">3%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">21%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">14%</td></tr><tr><td headers="hd_h_ml211.t4_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">51</td><td headers="hd_h_ml211.t4_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/49665497" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">SID 49665497</a></td><td headers="hd_h_ml211.t4_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-01000815269-1</td><td headers="hd_h_ml211.t4_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">
|
|
<div class="graphic"><img src="/books/NBK133440/bin/ml211fu56.jpg" alt="Image ml211fu56.jpg" /></div></td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">20%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">6%</td></tr><tr><td headers="hd_h_ml211.t4_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">52</td><td headers="hd_h_ml211.t4_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/17410082" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">SID 17410082</a></td><td headers="hd_h_ml211.t4_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-01000687666-1</td><td headers="hd_h_ml211.t4_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">
|
|
<div class="graphic"><img src="/books/NBK133440/bin/ml211fu57.jpg" alt="Image ml211fu57.jpg" /></div></td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_1" rowspan="1" colspan="1" style="background-color:#66FF33;text-align:center;vertical-align:middle;">57%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">12%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">7%</td></tr><tr><td headers="hd_h_ml211.t4_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">53</td><td headers="hd_h_ml211.t4_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/4249338" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">SID 4249338</a></td><td headers="hd_h_ml211.t4_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-01000134861-2</td><td headers="hd_h_ml211.t4_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">
|
|
<div class="graphic"><img src="/books/NBK133440/bin/ml211fu58.jpg" alt="Image ml211fu58.jpg" /></div></td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">1%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0%</td></tr><tr><td headers="hd_h_ml211.t4_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">54</td><td headers="hd_h_ml211.t4_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/17401582" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">SID 17401582</a></td><td headers="hd_h_ml211.t4_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-01000692129-1</td><td headers="hd_h_ml211.t4_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">
|
|
<div class="graphic"><img src="/books/NBK133440/bin/ml211fu59.jpg" alt="Image ml211fu59.jpg" /></div></td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0%</td></tr><tr><td headers="hd_h_ml211.t4_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">55</td><td headers="hd_h_ml211.t4_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/7974398" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">SID 7974398</a></td><td headers="hd_h_ml211.t4_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-01000625310-1</td><td headers="hd_h_ml211.t4_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">
|
|
<div class="graphic"><img src="/books/NBK133440/bin/ml211fu60.jpg" alt="Image ml211fu60.jpg" /></div></td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_1" rowspan="1" colspan="1" style="background-color:#66FF33;text-align:center;vertical-align:middle;">98%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_2" rowspan="1" colspan="1" style="background-color:#66FF33;text-align:center;vertical-align:middle;">76%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_3" rowspan="1" colspan="1" style="background-color:#66FF33;text-align:center;vertical-align:middle;">99%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_4" rowspan="1" colspan="1" style="background-color:#66FF33;text-align:center;vertical-align:middle;">88%</td></tr><tr><td headers="hd_h_ml211.t4_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">56</td><td headers="hd_h_ml211.t4_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/26661899" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">SID 26661899</a></td><td headers="hd_h_ml211.t4_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-01000771532-1</td><td headers="hd_h_ml211.t4_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">
|
|
<div class="graphic"><img src="/books/NBK133440/bin/ml211fu61.jpg" alt="Image ml211fu61.jpg" /></div></td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0%</td></tr><tr><td headers="hd_h_ml211.t4_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">57</td><td headers="hd_h_ml211.t4_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/49723678" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">SID 49723678</a></td><td headers="hd_h_ml211.t4_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-01000824659-1</td><td headers="hd_h_ml211.t4_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">
|
|
<div class="graphic"><img src="/books/NBK133440/bin/ml211fu62.jpg" alt="Image ml211fu62.jpg" /></div></td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">9%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0%</td></tr><tr><td headers="hd_h_ml211.t4_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">58</td><td headers="hd_h_ml211.t4_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/14728505" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">SID 14728505</a></td><td headers="hd_h_ml211.t4_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-01000712266-1</td><td headers="hd_h_ml211.t4_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">
|
|
<div class="graphic"><img src="/books/NBK133440/bin/ml211fu63.jpg" alt="Image ml211fu63.jpg" /></div></td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_2" rowspan="1" colspan="1" style="background-color:#66FF33;text-align:center;vertical-align:middle;">51%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_4" rowspan="1" colspan="1" style="background-color:#66FF33;text-align:center;vertical-align:middle;">73%</td></tr><tr><td headers="hd_h_ml211.t4_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">59</td><td headers="hd_h_ml211.t4_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/17413555" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">SID 17413555</a></td><td headers="hd_h_ml211.t4_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-01000690361-1</td><td headers="hd_h_ml211.t4_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">
|
|
<div class="graphic"><img src="/books/NBK133440/bin/ml211fu64.jpg" alt="Image ml211fu64.jpg" /></div></td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">10%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0%</td></tr><tr><td headers="hd_h_ml211.t4_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">60</td><td headers="hd_h_ml211.t4_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/22409916" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">SID 22409916</a></td><td headers="hd_h_ml211.t4_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-01000696739-1</td><td headers="hd_h_ml211.t4_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">
|
|
<div class="graphic"><img src="/books/NBK133440/bin/ml211fu65.jpg" alt="Image ml211fu65.jpg" /></div></td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">7%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">1%</td></tr><tr><td headers="hd_h_ml211.t4_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">61</td><td headers="hd_h_ml211.t4_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/4245654" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">SID 4245654</a></td><td headers="hd_h_ml211.t4_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-01000663277-1</td><td headers="hd_h_ml211.t4_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">
|
|
<div class="graphic"><img src="/books/NBK133440/bin/ml211fu66.jpg" alt="Image ml211fu66.jpg" /></div></td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_2" rowspan="1" colspan="1" style="background-color:#66FF33;text-align:center;vertical-align:middle;">45%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">2%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_4" rowspan="1" colspan="1" style="background-color:#66FF33;text-align:center;vertical-align:middle;">67%</td></tr><tr><td headers="hd_h_ml211.t4_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">62</td><td headers="hd_h_ml211.t4_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/17414118" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">SID 17414118</a></td><td headers="hd_h_ml211.t4_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-01000239878-2</td><td headers="hd_h_ml211.t4_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">
|
|
<div class="graphic"><img src="/books/NBK133440/bin/ml211fu67.jpg" alt="Image ml211fu67.jpg" /></div></td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">3%</td></tr><tr><td headers="hd_h_ml211.t4_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">63</td><td headers="hd_h_ml211.t4_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/26657842" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">SID 26657842</a></td><td headers="hd_h_ml211.t4_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-01000063073-2</td><td headers="hd_h_ml211.t4_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">
|
|
<div class="graphic"><img src="/books/NBK133440/bin/ml211fu68.jpg" alt="Image ml211fu68.jpg" /></div></td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">5%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">1%</td></tr><tr><td headers="hd_h_ml211.t4_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">64</td><td headers="hd_h_ml211.t4_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/47204055" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">SID 47204055</a></td><td headers="hd_h_ml211.t4_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-01000810587-1</td><td headers="hd_h_ml211.t4_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">
|
|
<div class="graphic"><img src="/books/NBK133440/bin/ml211fu69.jpg" alt="Image ml211fu69.jpg" /></div></td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_1" rowspan="1" colspan="1" style="background-color:#66FF33;text-align:center;vertical-align:middle;">65%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">23%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">3%</td></tr><tr><td headers="hd_h_ml211.t4_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">65</td><td headers="hd_h_ml211.t4_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/4249044" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">SID 4249044</a></td><td headers="hd_h_ml211.t4_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-01000620247-1</td><td headers="hd_h_ml211.t4_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">
|
|
<div class="graphic"><img src="/books/NBK133440/bin/ml211fu70.jpg" alt="Image ml211fu70.jpg" /></div></td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0%</td></tr><tr><td headers="hd_h_ml211.t4_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">66</td><td headers="hd_h_ml211.t4_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/14739159" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">SID 14739159</a></td><td headers="hd_h_ml211.t4_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-01000484074-2</td><td headers="hd_h_ml211.t4_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">
|
|
<div class="graphic"><img src="/books/NBK133440/bin/ml211fu71.jpg" alt="Image ml211fu71.jpg" /></div></td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">21%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0%</td></tr><tr><td headers="hd_h_ml211.t4_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">67</td><td headers="hd_h_ml211.t4_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/17412651" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">SID 17412651</a></td><td headers="hd_h_ml211.t4_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-01000691778-1</td><td headers="hd_h_ml211.t4_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">
|
|
<div class="graphic"><img src="/books/NBK133440/bin/ml211fu72.jpg" alt="Image ml211fu72.jpg" /></div></td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">4%</td></tr><tr><td headers="hd_h_ml211.t4_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">68</td><td headers="hd_h_ml211.t4_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/24802753" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">SID 24802753</a></td><td headers="hd_h_ml211.t4_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-01000725859-1</td><td headers="hd_h_ml211.t4_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">
|
|
<div class="graphic"><img src="/books/NBK133440/bin/ml211fu73.jpg" alt="Image ml211fu73.jpg" /></div></td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0%</td></tr><tr><td headers="hd_h_ml211.t4_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">69</td><td headers="hd_h_ml211.t4_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/17402168" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">SID 17402168</a></td><td headers="hd_h_ml211.t4_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-01000688424-1</td><td headers="hd_h_ml211.t4_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">
|
|
<div class="graphic"><img src="/books/NBK133440/bin/ml211fu74.jpg" alt="Image ml211fu74.jpg" /></div></td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">22%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">12%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">13%</td></tr><tr><td headers="hd_h_ml211.t4_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">70</td><td headers="hd_h_ml211.t4_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/49730654" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">SID 49730654</a></td><td headers="hd_h_ml211.t4_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-01000544533-2</td><td headers="hd_h_ml211.t4_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">
|
|
<div class="graphic"><img src="/books/NBK133440/bin/ml211fu75.jpg" alt="Image ml211fu75.jpg" /></div></td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_1" rowspan="1" colspan="1" style="background-color:#66FF33;text-align:center;vertical-align:middle;">31%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_2" rowspan="1" colspan="1" style="background-color:#66FF33;text-align:center;vertical-align:middle;">30%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_4" rowspan="1" colspan="1" style="background-color:#66FF33;text-align:center;vertical-align:middle;">46%</td></tr><tr><td headers="hd_h_ml211.t4_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">71</td><td headers="hd_h_ml211.t4_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/57258894" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">SID 57258894</a></td><td headers="hd_h_ml211.t4_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-01000856882-1</td><td headers="hd_h_ml211.t4_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">
|
|
<div class="graphic"><img src="/books/NBK133440/bin/ml211fu76.jpg" alt="Image ml211fu76.jpg" /></div></td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_1" rowspan="1" colspan="1" style="background-color:#66FF33;text-align:center;vertical-align:middle;">31%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">4%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">4%</td></tr><tr><td headers="hd_h_ml211.t4_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">72</td><td headers="hd_h_ml211.t4_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/26666664" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">SID 26666664</a></td><td headers="hd_h_ml211.t4_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-01000775898-1</td><td headers="hd_h_ml211.t4_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">
|
|
<div class="graphic"><img src="/books/NBK133440/bin/ml211fu77.jpg" alt="Image ml211fu77.jpg" /></div></td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">17%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">5%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">14%</td></tr><tr><td headers="hd_h_ml211.t4_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">73</td><td headers="hd_h_ml211.t4_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/47199703" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">SID 47199703</a></td><td headers="hd_h_ml211.t4_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-01000787295-1</td><td headers="hd_h_ml211.t4_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">
|
|
<div class="graphic"><img src="/books/NBK133440/bin/ml211fu78.jpg" alt="Image ml211fu78.jpg" /></div></td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">7%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">2%</td></tr><tr><td headers="hd_h_ml211.t4_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">74</td><td headers="hd_h_ml211.t4_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/47201220" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">SID 47201220</a></td><td headers="hd_h_ml211.t4_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-01000809404-1</td><td headers="hd_h_ml211.t4_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">
|
|
<div class="graphic"><img src="/books/NBK133440/bin/ml211fu79.jpg" alt="Image ml211fu79.jpg" /></div></td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">2%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">1%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">7%</td></tr><tr><td headers="hd_h_ml211.t4_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">75</td><td headers="hd_h_ml211.t4_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/24832013" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">SID 24832013</a></td><td headers="hd_h_ml211.t4_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-01000752319-1</td><td headers="hd_h_ml211.t4_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">
|
|
<div class="graphic"><img src="/books/NBK133440/bin/ml211fu80.jpg" alt="Image ml211fu80.jpg" /></div></td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">6%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">17%</td></tr><tr><td headers="hd_h_ml211.t4_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">76</td><td headers="hd_h_ml211.t4_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/47202607" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">SID 47202607</a></td><td headers="hd_h_ml211.t4_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-01000788395-1</td><td headers="hd_h_ml211.t4_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">
|
|
<div class="graphic"><img src="/books/NBK133440/bin/ml211fu81.jpg" alt="Image ml211fu81.jpg" /></div></td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_1" rowspan="1" colspan="1" style="background-color:#66FF33;text-align:center;vertical-align:middle;">31%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0%</td></tr><tr><td headers="hd_h_ml211.t4_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">77</td><td headers="hd_h_ml211.t4_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/49674578" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">SID 49674578</a></td><td headers="hd_h_ml211.t4_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-01000052376-2</td><td headers="hd_h_ml211.t4_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">
|
|
<div class="graphic"><img src="/books/NBK133440/bin/ml211fu82.jpg" alt="Image ml211fu82.jpg" /></div></td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_1" rowspan="1" colspan="1" style="background-color:#66FF33;text-align:center;vertical-align:middle;">49%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0%</td></tr><tr><td headers="hd_h_ml211.t4_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">78</td><td headers="hd_h_ml211.t4_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/14736972" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">SID 14736972</a></td><td headers="hd_h_ml211.t4_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-01000693659-1</td><td headers="hd_h_ml211.t4_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">
|
|
<div class="graphic"><img src="/books/NBK133440/bin/ml211fu83.jpg" alt="Image ml211fu83.jpg" /></div></td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0%</td></tr><tr><td headers="hd_h_ml211.t4_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">79</td><td headers="hd_h_ml211.t4_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/24823516" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">SID 24823516</a></td><td headers="hd_h_ml211.t4_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-01000740492-1</td><td headers="hd_h_ml211.t4_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">
|
|
<div class="graphic"><img src="/books/NBK133440/bin/ml211fu84.jpg" alt="Image ml211fu84.jpg" /></div></td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">3%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">1%</td></tr><tr><td headers="hd_h_ml211.t4_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">80</td><td headers="hd_h_ml211.t4_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/14735099" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">SID 14735099</a></td><td headers="hd_h_ml211.t4_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-01000667237-1</td><td headers="hd_h_ml211.t4_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">
|
|
<div class="graphic"><img src="/books/NBK133440/bin/ml211fu85.jpg" alt="Image ml211fu85.jpg" /></div></td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">9%</td></tr><tr><td headers="hd_h_ml211.t4_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">81</td><td headers="hd_h_ml211.t4_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/14722150" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">SID 14722150</a></td><td headers="hd_h_ml211.t4_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-01000693517-1</td><td headers="hd_h_ml211.t4_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">
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<div class="graphic"><img src="/books/NBK133440/bin/ml211fu86.jpg" alt="Image ml211fu86.jpg" /></div></td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_1" rowspan="1" colspan="1" style="background-color:#66FF33;text-align:center;vertical-align:middle;">60%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_3" rowspan="1" colspan="1" style="background-color:#66FF33;text-align:center;vertical-align:middle;">37%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0%</td></tr><tr><td headers="hd_h_ml211.t4_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">82</td><td headers="hd_h_ml211.t4_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/16953314" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">SID 16953314</a></td><td headers="hd_h_ml211.t4_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-01000672777-1</td><td headers="hd_h_ml211.t4_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">
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<div class="graphic"><img src="/books/NBK133440/bin/ml211fu87.jpg" alt="Image ml211fu87.jpg" /></div></td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">16%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">3%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0%</td></tr><tr><td headers="hd_h_ml211.t4_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">83</td><td headers="hd_h_ml211.t4_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/4244341" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">SID 4244341</a></td><td headers="hd_h_ml211.t4_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-01000595170-2</td><td headers="hd_h_ml211.t4_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">
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<div class="graphic"><img src="/books/NBK133440/bin/ml211fu88.jpg" alt="Image ml211fu88.jpg" /></div></td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_1" rowspan="1" colspan="1" style="background-color:#66FF33;text-align:center;vertical-align:middle;">78%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_3" rowspan="1" colspan="1" style="background-color:#66FF33;text-align:center;vertical-align:middle;">60%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">13%</td></tr><tr><td headers="hd_h_ml211.t4_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">84</td><td headers="hd_h_ml211.t4_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/47199863" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">SID 47199863</a></td><td headers="hd_h_ml211.t4_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-01000788400-1</td><td headers="hd_h_ml211.t4_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">
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<div class="graphic"><img src="/books/NBK133440/bin/ml211fu89.jpg" alt="Image ml211fu89.jpg" /></div></td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">21%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">11%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">9%</td></tr><tr><td headers="hd_h_ml211.t4_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">85</td><td headers="hd_h_ml211.t4_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/26666153" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">SID 26666153</a></td><td headers="hd_h_ml211.t4_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-01000772836-1</td><td headers="hd_h_ml211.t4_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">
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|
<div class="graphic"><img src="/books/NBK133440/bin/ml211fu90.jpg" alt="Image ml211fu90.jpg" /></div></td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_1" rowspan="1" colspan="1" style="background-color:#66FF33;text-align:center;vertical-align:middle;">44%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">15%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">10%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_4" rowspan="1" colspan="1" style="background-color:#66FF33;text-align:center;vertical-align:middle;">31%</td></tr><tr><td headers="hd_h_ml211.t4_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">86</td><td headers="hd_h_ml211.t4_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/24797536" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">SID 24797536</a></td><td headers="hd_h_ml211.t4_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-01000722956-1</td><td headers="hd_h_ml211.t4_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">
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<div class="graphic"><img src="/books/NBK133440/bin/ml211fu91.jpg" alt="Image ml211fu91.jpg" /></div></td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">25%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">21%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">13%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_4" rowspan="1" colspan="1" style="background-color:#66FF33;text-align:center;vertical-align:middle;">40%</td></tr><tr><td headers="hd_h_ml211.t4_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">87</td><td headers="hd_h_ml211.t4_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/24790353" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">SID 24790353</a></td><td headers="hd_h_ml211.t4_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-01000722563-1</td><td headers="hd_h_ml211.t4_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">
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<div class="graphic"><img src="/books/NBK133440/bin/ml211fu92.jpg" alt="Image ml211fu92.jpg" /></div></td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">2%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0%</td></tr><tr><td headers="hd_h_ml211.t4_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">88</td><td headers="hd_h_ml211.t4_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/3717341" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">SID 3717341</a></td><td headers="hd_h_ml211.t4_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-01000605533-1</td><td headers="hd_h_ml211.t4_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">
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<div class="graphic"><img src="/books/NBK133440/bin/ml211fu93.jpg" alt="Image ml211fu93.jpg" /></div></td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">20%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">6%</td></tr><tr><td headers="hd_h_ml211.t4_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">89</td><td headers="hd_h_ml211.t4_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/14720958" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">SID 14720958</a></td><td headers="hd_h_ml211.t4_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-01000680759-1</td><td headers="hd_h_ml211.t4_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">
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<div class="graphic"><img src="/books/NBK133440/bin/ml211fu94.jpg" alt="Image ml211fu94.jpg" /></div></td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">17%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">2%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">17%</td></tr><tr><td headers="hd_h_ml211.t4_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">90</td><td headers="hd_h_ml211.t4_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/49729467" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">SID 49729467</a></td><td headers="hd_h_ml211.t4_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-01000822231-1</td><td headers="hd_h_ml211.t4_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">
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<div class="graphic"><img src="/books/NBK133440/bin/ml211fu95.jpg" alt="Image ml211fu95.jpg" /></div></td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">1%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">8%</td></tr><tr><td headers="hd_h_ml211.t4_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">91</td><td headers="hd_h_ml211.t4_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><a href="https://pubchem.ncbi.nlm.nih.gov/substance/22412688" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">SID 22412688</a></td><td headers="hd_h_ml211.t4_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">SR-01000720332-1</td><td headers="hd_h_ml211.t4_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">
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<div class="graphic"><img src="/books/NBK133440/bin/ml211fu96.jpg" alt="Image ml211fu96.jpg" /></div></td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">0%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">8%</td><td headers="hd_h_ml211.t4_1_1_1_5 hd_h_ml211.t4_1_1_2_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">8%</td></tr></tbody></table></div><div class="tblwrap-foot"><div><dl class="temp-labeled-list small"><dl class="bkr_refwrap"><dt></dt><dd><div id="ml211.tfn9"><p class="no_margin">Green highlight: active</p></div></dd></dl><dl class="bkr_refwrap"><dt></dt><dd><div id="ml211.tfn10"><p class="no_margin">ND: not determined due to poor band resolution</p></div></dd></dl></dl></div></div></div></article></div><div id="jr-scripts"><script src="/corehtml/pmc/jatsreader/ptpmc_3.22/js/libs.min.js"> </script><script src="/corehtml/pmc/jatsreader/ptpmc_3.22/js/jr.min.js"> </script></div></div>
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