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<meta name="ncbi_pagename" content="111In-Tetrameric Plectin-1 targeting peptide (4(βAKTLLPTP-GGS(PEG5000))KKK-111In-DOTA-βA-NH2) - Molecular Imaging and Contrast Agent Database (MICAD) - NCBI Bookshelf">
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<script type="text/javascript" src="/corehtml/pmc/jatsreader/ptpmc_3.22/js/jr.boots.min.js"> </script><title>111In-Tetrameric Plectin-1 targeting peptide (4(βAKTLLPTP-GGS(PEG5000))KKK-111In-DOTA-βA-NH2) - Molecular Imaging and Contrast Agent Database (MICAD) - NCBI Bookshelf</title>
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<meta name="citation_inbook_title" content="Molecular Imaging and Contrast Agent Database (MICAD) [Internet]">
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<meta name="citation_title" content="111In-Tetrameric Plectin-1 targeting peptide (4(βAKTLLPTP-GGS(PEG5000))KKK-111In-DOTA-βA-NH2)">
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<meta name="citation_publisher" content="National Center for Biotechnology Information (US)">
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<meta name="citation_date" content="2011/04/27">
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<meta name="citation_author" content="Kam Leung">
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<meta name="citation_pmid" content="21542555">
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<meta name="DC.Title" content="111In-Tetrameric Plectin-1 targeting peptide (4(βAKTLLPTP-GGS(PEG5000))KKK-111In-DOTA-βA-NH2)">
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<meta name="DC.Contributor" content="Kam Leung">
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<meta name="DC.Date" content="2011/04/27">
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<meta name="description" content="Patients with pancreatic ductal adenocarcinoma (PDAC) have a median survival of 6 months and a 5-year survival rate of only 3% (1). PDAC is an aggressive cancer with early metastasis in >80% of patients. Early detection would be particularly useful for monitoring people at high risk of developing pancreatic cancer. Plectin-1 was identified in 100% of tested PDAC lesions and 60% of tested preinvasive PanIN III lesions (2). Plectin-1, a cytoskeletal component, is not expressed in the normal pancreas, liver, lymph node, lung, or peritoneum in humans. Using phage display screenings, the linear peptide Lys-Thr-Leu-Leu-Pro-Thr-Pro (KTLLPTP) (Plectin-1–targeting peptide, PTP) (3) has been found to specifically bind to Plectin-1 (4, 5), a protein present both inside and on the membrane of human and mouse PDAC cells but only on the inside of normal pancreatic cells. Kelly et al. (3) conjugated PTP to Cy5.5-labeled cross-linked iron oxide particles (CLIO-Cy5.5) for imaging Plectin-1 expression in PDAC, which suggests that Plectin-1 can serve as a biomarker for PDAC. Bausch et al. (2) labeled a tetrameric PTP with 111In (4(βAKTLLPTP-GGS(PEG5000))KKK-111In-DOTA-βA-NH2) (111In-tPTP) for single-photon emission computed tomography (SPECT) imaging for primary and metastatic pancreatic tumors.">
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<meta name="og:description" content="Patients with pancreatic ductal adenocarcinoma (PDAC) have a median survival of 6 months and a 5-year survival rate of only 3% (1). PDAC is an aggressive cancer with early metastasis in >80% of patients. Early detection would be particularly useful for monitoring people at high risk of developing pancreatic cancer. Plectin-1 was identified in 100% of tested PDAC lesions and 60% of tested preinvasive PanIN III lesions (2). Plectin-1, a cytoskeletal component, is not expressed in the normal pancreas, liver, lymph node, lung, or peritoneum in humans. Using phage display screenings, the linear peptide Lys-Thr-Leu-Leu-Pro-Thr-Pro (KTLLPTP) (Plectin-1–targeting peptide, PTP) (3) has been found to specifically bind to Plectin-1 (4, 5), a protein present both inside and on the membrane of human and mouse PDAC cells but only on the inside of normal pancreatic cells. Kelly et al. (3) conjugated PTP to Cy5.5-labeled cross-linked iron oxide particles (CLIO-Cy5.5) for imaging Plectin-1 expression in PDAC, which suggests that Plectin-1 can serve as a biomarker for PDAC. Bausch et al. (2) labeled a tetrameric PTP with 111In (4(βAKTLLPTP-GGS(PEG5000))KKK-111In-DOTA-βA-NH2) (111In-tPTP) for single-photon emission computed tomography (SPECT) imaging for primary and metastatic pancreatic tumors.">
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id="jr-fip-info-p"><a id="jr-fip-prev" class="wsprkl btn" title="Jump to previuos match">◀</a><button id="jr-fip-matches">no matches yet</button><a id="jr-fip-next" class="wsprkl btn" title="Jump to next match">▶</a></nav></nav></div><div id="jr-epub-interstitial" class="hidden"></div><div id="jr-content"><article data-type="main"><div class="main-content lit-style" itemscope="itemscope" itemtype="http://schema.org/CreativeWork"><div class="meta-content fm-sec"><div class="fm-sec"><h1 id="_NBK54202_"><span class="title" itemprop="name"><sup>111</sup>In-Tetrameric Plectin-1 targeting peptide (4(βAKTLLPTP-GGS(PEG5000))KKK-<sup>111</sup>In-DOTA-βA-NH<sub>2</sub>)</span></h1><div itemprop="alternativeHeadline" class="subtitle whole_rhythm"><sup>111</sup>In-tPTP</div><p class="contribs">Leung K.</p><p class="fm-aai"><a href="#_NBK54202_pubdet_">Publication Details</a></p></div></div><div class="jig-ncbiinpagenav body-content whole_rhythm" data-jigconfig="allHeadingLevels: ['h2'],smoothScroll: false" itemprop="text"><div class="iconblock whole_rhythm clearfix ten_col table-wrap" id="figtPTP111InTncchemicalname111intetrame"><a href="/books/NBK54202/table/tPTP111In.T.nc_chemical_name111intetrame/?report=objectonly" target="object" title="Table" class="img_link icnblk_img" rid-ob="figobtPTP111InTncchemicalname111intetrame"><img class="small-thumb" src="/corehtml/pmc/css/bookshelf/2.26/img/table-icon.gif" alt="Table Icon" /></a><div class="icnblk_cntnt"><h4 id="tPTP111In.T.nc_chemical_name111intetrame"><a href="/books/NBK54202/table/tPTP111In.T.nc_chemical_name111intetrame/?report=objectonly" target="object" rid-ob="figobtPTP111InTncchemicalname111intetrame">Table</a></h4><p class="float-caption no_bottom_margin">
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<i>In vitro</i>
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Rodents
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</p></div></div><div id="tPTP111In.Background"><h2 id="_tPTP111In_Background_">Background</h2><p>[<a href="/entrez/query.fcgi?cmd=PureSearch&db=pubmed&details_term=tPTP" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">PubMed</a>]</p><p>Patients with pancreatic ductal adenocarcinoma (PDAC) have a median survival of 6 months and a 5-year survival rate of only 3% (<a class="bibr" href="#tPTP111In.REF.1" rid="tPTP111In.REF.1">1</a>). PDAC is an aggressive cancer with early metastasis in >80% of patients. Early detection would be particularly useful for monitoring people at high risk of developing pancreatic cancer. Plectin-1 was identified in 100% of tested PDAC lesions and 60% of tested preinvasive PanIN III lesions (<a class="bibr" href="#tPTP111In.REF.2" rid="tPTP111In.REF.2">2</a>). Plectin-1, a cytoskeletal component, is not expressed in the normal pancreas, liver, lymph node, lung, or peritoneum in humans. Using phage display screenings, the linear peptide Lys-Thr-Leu-Leu-Pro-Thr-Pro (KTLLPTP) (Plectin-1–targeting peptide, PTP) (<a class="bibr" href="#tPTP111In.REF.3" rid="tPTP111In.REF.3">3</a>) has been found to specifically bind to Plectin-1 (<a class="bibr" href="#tPTP111In.REF.4" rid="tPTP111In.REF.4 tPTP111In.REF.5">4, 5</a>), a protein present both inside and on the membrane of human and mouse PDAC cells but only on the inside of normal pancreatic cells. Kelly et al. (<a class="bibr" href="#tPTP111In.REF.3" rid="tPTP111In.REF.3">3</a>) conjugated PTP to Cy5.5-labeled cross-linked iron oxide particles (CLIO-Cy5.5) for imaging Plectin-1 expression in PDAC, which suggests that Plectin-1 can serve as a biomarker for PDAC. Bausch et al. (<a class="bibr" href="#tPTP111In.REF.2" rid="tPTP111In.REF.2">2</a>) labeled a tetrameric PTP with <sup>111</sup>In (4(βAKTLLPTP-GGS(PEG5000))KKK-<sup>111</sup>In-DOTA-βA-NH<sub>2</sub>) (<sup>111</sup>In-tPTP) for single-photon emission computed tomography (SPECT) imaging for primary and metastatic pancreatic tumors.</p><div id="tPTP111In.Related_Resource_Links"><h3>Related Resource Links:</h3><ul><li class="half_rhythm"><div>Chapters in MICAD (<a href="/sites/entrez?Db=books&Cmd=DetailsSearch&Term=Plectin-1%5BAll+Fields%5D+AND+micad%5Bbook%5D" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">Plectin-1</a>)</div></li><li class="half_rhythm"><div>Gene information in NCBI (<a href="/gene/5339" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">Plectin-1</a>).</div></li><li class="half_rhythm"><div>Articles in Online Mendelian Inheritance in Man (OMIM) (<a href="/omim/601282" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">Plectin-1</a>)</div></li></ul></div></div><div id="tPTP111In.Synthesis"><h2 id="_tPTP111In_Synthesis_">Synthesis</h2><p>[<a href="/entrez/query.fcgi?cmd=PureSearch&db=pubmed&details_term=tPTP%20and%20synthesis" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">PubMed</a>]</p><p>4(βAKTLLPTP-GGS(PEG5000))KKK-DOTA-βA-NH<sub>2</sub> (tPTP) (100 µg) was incubated with 185 MBq (5 mCi) <sup>111</sup>InCl<sub>3</sub> in ammonium acetate buffer (pH 4.5) for 15 min at 40°C (<a class="bibr" href="#tPTP111In.REF.2" rid="tPTP111In.REF.2">2</a>). <sup>111</sup>In-tPTP was purified with column chromatography. The yield, radiochemical purity, and specific activity of <sup>111</sup>In-tPTP were not reported.</p></div><div id="tPTP111In.In_Vitro_Studies_Testing_in_Ce"><h2 id="_tPTP111In_In_Vitro_Studies_Testing_in_Ce_"><i>In Vitro</i> Studies: Testing in Cells and Tissues</h2><p>[<a href="/entrez/query.fcgi?cmd=PureSearch&db=pubmed&details_term=tPTP%20and%20in%20vitro" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">PubMed</a>]</p><p>Competition binding assays were performed in Plectin-1–positive L3.6pl PDAC cells using <sup>111</sup>In-tPTP with tPTP. tPTP had a <i>K</i><sub>i</sub> value of 830 nM (<a class="bibr" href="#tPTP111In.REF.2" rid="tPTP111In.REF.2">2</a>).</p></div><div id="tPTP111In.Animal_Studies"><h2 id="_tPTP111In_Animal_Studies_">Animal Studies</h2><div id="tPTP111In.Rodents"><h3>Rodents</h3><p>[<a href="/entrez/query.fcgi?cmd=PureSearch&db=pubmed&details_term=tPTP%20and%20rodentia" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">PubMed</a>]</p><p>Bausch et al. (<a class="bibr" href="#tPTP111In.REF.2" rid="tPTP111In.REF.2">2</a>) performed <i>ex vivo</i> biodistribution studies in mice bearing orthotopically implanted L3.6pl (<i>n</i> = 10), Panc1 (<i>n</i> = 5), or AK134 (<i>n</i> = 8) PDAC tumor cells at 4 h after injection of 37 MBq (1 mCi) <sup>111</sup>In-tPTP. Tumor accumulation of radioactivity was 2.0% injected dose per gram (ID/g), 1.8% ID/g, 1.5% ID/g, and 0.5% ID/g for L3.6pl, Panc1, AK134, and normal pancreas, respectively. Accumulation in these mice was highest in the kidney with 15%–22% ID/g, followed by the liver with 1.7%–2.6% ID/g. Immunohistochemistry of sections of the pancreas and peritoneum metastases confirmed the presence of Plectin-1–expressing tumor cells in the pancreas and peritoneum.</p><p>SPECT scanning clearly visualized the three tumors and the kidneys at 4 h after injection. SPECT scanning located metastases in the peritoneum of two mice, which were confirmed with autopsy. In a model of AK134 PDAC liver metastasis, SPECT/computed tomography scanning clearly identified tumor lesions in the liver, which were confirmed with autopsy.</p></div><div id="tPTP111In.Other_NonPrimate_Mammals"><h3>Other Non-Primate Mammals</h3><p>[<a href="/entrez/query.fcgi?cmd=PureSearch&db=pubmed&details_term=tPTP%20and%20%28dog%20or%20pig%20or%20sheep%20or%20rabbit%29" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">PubMed</a>]</p><p>No publication is currently available.</p></div><div id="tPTP111In.NonHuman_Primates"><h3>Non-Human Primates</h3><p>[<a href="/entrez/query.fcgi?cmd=PureSearch&db=pubmed&details_term=tPTP%20and%20%28primate%20not%20human%29" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">PubMed</a>]</p><p>No publication is currently available.</p></div></div><div id="tPTP111In.Human_Studies"><h2 id="_tPTP111In_Human_Studies_">Human Studies</h2><p>[<a href="/entrez/query.fcgi?cmd=PureSearch&db=pubmed&details_term=tPTP%20and%20human" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">PubMed</a>]</p><p>No publication is currently available.</p></div><div id="tPTP111In.NIH_Support"><h2 id="_tPTP111In_NIH_Support_">NIH Support</h2><p>R01 CA137071-02, R01 CA137071-04, R01 EB010023-01A1, R01 EB010023-02</p></div><div id="tPTP111In.References"><h2 id="_tPTP111In_References_">References</h2><dl class="temp-labeled-list"><dl class="bkr_refwrap"><dt>1.</dt><dd><div class="bk_ref" id="tPTP111In.REF.1">Li D., Xie K., Wolff R., Abbruzzese J.L.
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<em>Pancreatic cancer.</em>
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<span><span class="ref-journal">Lancet. </span>2004;<span class="ref-vol">363</span>(9414):1049–57.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/15051286" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 15051286</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>2.</dt><dd><div class="bk_ref" id="tPTP111In.REF.2">Bausch D., Thomas S., Mino-Kenudson M., Fernandez-del C.C., Bauer T.W., Williams M., Warshaw A.L., Thayer S.P., Kelly K.A.
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<em>Plectin-1 as a novel biomarker for pancreatic cancer.</em>
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<span><span class="ref-journal">Clin Cancer Res. </span>2011;<span class="ref-vol">17</span>(2):302–9.</span> [<a href="/pmc/articles/PMC3044444/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC3044444</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/21098698" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 21098698</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>3.</dt><dd><div class="bk_ref" id="tPTP111In.REF.3">Kelly K.A., Bardeesy N., Anbazhagan R., Gurumurthy S., Berger J., Alencar H., Depinho R.A., Mahmood U., Weissleder R.
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<em>Targeted nanoparticles for imaging incipient pancreatic ductal adenocarcinoma.</em>
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<span><span class="ref-journal">PLoS Med. </span>2008;<span class="ref-vol">5</span>(4):e85.</span> [<a href="/pmc/articles/PMC2292750/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC2292750</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/18416599" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 18416599</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>4.</dt><dd><div class="bk_ref" id="tPTP111In.REF.4">Andra K., Kornacker I., Jorgl A., Zorer M., Spazierer D., Fuchs P., Fischer I., Wiche G.
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<em>Plectin-isoform-specific rescue of hemidesmosomal defects in plectin (-/-) keratinocytes.</em>
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<span><span class="ref-journal">J Invest Dermatol. </span>2003;<span class="ref-vol">120</span>(2):189–97.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/12542521" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 12542521</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>5.</dt><dd><div class="bk_ref" id="tPTP111In.REF.5">Sonnenberg A., Liem R.K.
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<em>Plakins in development and disease.</em>
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<span><span class="ref-journal">Exp Cell Res. </span>2007;<span class="ref-vol">313</span>(10):2189–203.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/17499243" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 17499243</span></a>]</div></dd></dl></dl></div><div id="bk_toc_contnr"></div></div></div><div class="fm-sec"><h2 id="_NBK54202_pubdet_">Publication Details</h2><h3>Author Information and Affiliations</h3><div class="contrib half_rhythm"><span itemprop="author">Kam Leung</span>, PhD<div class="affiliation small">National Center for Biotechnology Information, NLM, NIH, Bethesda, MD<div><span class="email-label">Email: </span><a href="mailto:dev@null" data-email="vog.hin.mln.ibcn@dacim" class="oemail">vog.hin.mln.ibcn@dacim</a></div></div><div class="small">Corresponding author.</div></div><h3>Publication History</h3><p class="small">Created: <span itemprop="datePublished">January 28, 2011</span>; Last Update: <span itemprop="dateModified">April 27, 2011</span>.</p><h3>Copyright</h3><div><div class="half_rhythm"><a href="/books/about/copyright/">Copyright Notice</a></div></div><h3>Publisher</h3><p><a href="http://www.ncbi.nlm.nih.gov/" ref="pagearea=page-banner&targetsite=external&targetcat=link&targettype=publisher">National Center for Biotechnology Information (US)</a>, Bethesda (MD)</p><h3>NLM Citation</h3><p>Leung K. 111In-Tetrameric Plectin-1 targeting peptide (4(βAKTLLPTP-GGS(PEG5000))KKK-111In-DOTA-βA-NH2) 2011 Jan 28 [Updated 2011 Apr 27]. In: Molecular Imaging and Contrast Agent Database (MICAD) [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2004-2013. <span class="bk_cite_avail"></span></p></div><div class="small-screen-prev"><a href="/books/n/micad/H6Met111In/?report=reader"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 100 100" preserveAspectRatio="none"><path d="M75,30 c-80,60 -80,0 0,60 c-30,-60 -30,0 0,-60"></path><text x="20" y="28" textLength="60" style="font-size:25px">Prev</text></svg></a></div><div class="small-screen-next"><a href="/books/n/micad/TrastFab111In/?report=reader"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 100 100" preserveAspectRatio="none"><path d="M25,30c80,60 80,0 0,60 c30,-60 30,0 0,-60"></path><text x="20" y="28" textLength="60" style="font-size:25px">Next</text></svg></a></div></article><article data-type="table-wrap" id="figobtPTP111InTncchemicalname111intetrame"><div id="tPTP111In.T.nc_chemical_name111intetrame" class="table"><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK54202/table/tPTP111In.T.nc_chemical_name111intetrame/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__tPTP111In.T.nc_chemical_name111intetrame_lrgtbl__"><table><tbody><tr><td rowspan="1" colspan="1" style="text-align:right;vertical-align:top;">
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<b>Chemical name:</b>
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</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"><sup>111</sup>In-Tetrameric Plectin-1 targeting peptide (4(βAKTLLPTP-GGS(PEG5000))KKK-<sup>111</sup>In-DOTA-βA-NH<sub>2</sub>)</td><td rowspan="9" colspan="1" style="text-align:center;vertical-align:middle;"></td></tr><tr><td rowspan="1" colspan="1" style="text-align:right;vertical-align:top;">
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<b>Abbreviated name:</b>
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</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"><sup>111</sup>In-tPTP</td></tr><tr><td rowspan="1" colspan="1" style="text-align:right;vertical-align:top;">
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<b>Synonym:</b>
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</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"><sup>111</sup>In-Tetrameric Plectin-1 targeting peptide</td></tr><tr><td rowspan="1" colspan="1" style="text-align:right;vertical-align:top;">
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<b>Agent category:</b>
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</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Peptide</td></tr><tr><td rowspan="1" colspan="1" style="text-align:right;vertical-align:top;">
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<b>Target:</b>
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</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Plectin-1</td></tr><tr><td rowspan="1" colspan="1" style="text-align:right;vertical-align:top;">
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<b>Target category:</b>
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</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Receptor</td></tr><tr><td rowspan="1" colspan="1" style="text-align:right;vertical-align:top;">
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<b>Method of detection:</b>
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</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Single-photon emission computed tomography (SPECT), gamma imaging</td></tr><tr><td rowspan="1" colspan="1" style="text-align:right;vertical-align:top;">
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<b>Source of signal\contrast:</b>
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</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"><sup>111</sup>In</td></tr><tr><td rowspan="1" colspan="1" style="text-align:right;vertical-align:top;">
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<b>Activation:</b>
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</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">No</td></tr><tr><td rowspan="1" colspan="1" style="text-align:right;vertical-align:top;">
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<b>Studies:</b>
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</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<ul class="simple-list"><li class="half_rhythm"><div>
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<img alt="Checkbox" src="/corehtml/pmc/css/bookshelf/2.26/img/studies.checkbox.png" />
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<i>In vitro</i>
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</div></li><li class="half_rhythm"><div>
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<img alt="Checkbox" src="/corehtml/pmc/css/bookshelf/2.26/img/studies.checkbox.png" /> Rodents
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</div></li></ul>
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</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Click on <a href="/entrez/viewer.fcgi?db=protein&id=134044255" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">protein</a>, <a href="/entrez/viewer.fcgi?db=nuccore&id=47607491" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">nucleotide</a> (RefSeq), and <a href="/entrez/query.fcgi?db=gene&cmd=Retrieve&dopt=full_report&list_uids=5339" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">gene</a> for more information about Plectin-1.</td></tr></tbody></table></div></div></article></div><div id="jr-scripts"><script src="/corehtml/pmc/jatsreader/ptpmc_3.22/js/libs.min.js"> </script><script src="/corehtml/pmc/jatsreader/ptpmc_3.22/js/jr.min.js"> </script></div></div>
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