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<title>111In-Tetrameric Plectin-1 targeting peptide (4(βAKTLLPTP-GGS(PEG5000))KKK-111In-DOTA-βA-NH2) - Molecular Imaging and Contrast Agent Database (MICAD) - NCBI Bookshelf</title>
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<meta name="robots" content="INDEX,FOLLOW,NOARCHIVE" /><meta name="citation_inbook_title" content="Molecular Imaging and Contrast Agent Database (MICAD) [Internet]" /><meta name="citation_title" content="111In-Tetrameric Plectin-1 targeting peptide (4(βAKTLLPTP-GGS(PEG5000))KKK-111In-DOTA-βA-NH2)" /><meta name="citation_publisher" content="National Center for Biotechnology Information (US)" /><meta name="citation_date" content="2011/04/27" /><meta name="citation_author" content="Kam Leung" /><meta name="citation_pmid" content="21542555" /><meta name="citation_fulltext_html_url" content="https://www.ncbi.nlm.nih.gov/books/NBK54202/" /><link rel="schema.DC" href="http://purl.org/DC/elements/1.0/" /><meta name="DC.Title" content="111In-Tetrameric Plectin-1 targeting peptide (4(βAKTLLPTP-GGS(PEG5000))KKK-111In-DOTA-βA-NH2)" /><meta name="DC.Type" content="Text" /><meta name="DC.Publisher" content="National Center for Biotechnology Information (US)" /><meta name="DC.Contributor" content="Kam Leung" /><meta name="DC.Date" content="2011/04/27" /><meta name="DC.Identifier" content="https://www.ncbi.nlm.nih.gov/books/NBK54202/" /><meta name="description" content="Patients with pancreatic ductal adenocarcinoma (PDAC) have a median survival of 6 months and a 5-year survival rate of only 3% (1). PDAC is an aggressive cancer with early metastasis in >80% of patients. Early detection would be particularly useful for monitoring people at high risk of developing pancreatic cancer. Plectin-1 was identified in 100% of tested PDAC lesions and 60% of tested preinvasive PanIN III lesions (2). Plectin-1, a cytoskeletal component, is not expressed in the normal pancreas, liver, lymph node, lung, or peritoneum in humans. Using phage display screenings, the linear peptide Lys-Thr-Leu-Leu-Pro-Thr-Pro (KTLLPTP) (Plectin-1–targeting peptide, PTP) (3) has been found to specifically bind to Plectin-1 (4, 5), a protein present both inside and on the membrane of human and mouse PDAC cells but only on the inside of normal pancreatic cells. Kelly et al. (3) conjugated PTP to Cy5.5-labeled cross-linked iron oxide particles (CLIO-Cy5.5) for imaging Plectin-1 expression in PDAC, which suggests that Plectin-1 can serve as a biomarker for PDAC. Bausch et al. (2) labeled a tetrameric PTP with 111In (4(βAKTLLPTP-GGS(PEG5000))KKK-111In-DOTA-βA-NH2) (111In-tPTP) for single-photon emission computed tomography (SPECT) imaging for primary and metastatic pancreatic tumors." /><meta name="og:title" content="111In-Tetrameric Plectin-1 targeting peptide (4(βAKTLLPTP-GGS(PEG5000))KKK-111In-DOTA-βA-NH2)" /><meta name="og:type" content="book" /><meta name="og:description" content="Patients with pancreatic ductal adenocarcinoma (PDAC) have a median survival of 6 months and a 5-year survival rate of only 3% (1). PDAC is an aggressive cancer with early metastasis in >80% of patients. Early detection would be particularly useful for monitoring people at high risk of developing pancreatic cancer. Plectin-1 was identified in 100% of tested PDAC lesions and 60% of tested preinvasive PanIN III lesions (2). Plectin-1, a cytoskeletal component, is not expressed in the normal pancreas, liver, lymph node, lung, or peritoneum in humans. Using phage display screenings, the linear peptide Lys-Thr-Leu-Leu-Pro-Thr-Pro (KTLLPTP) (Plectin-1–targeting peptide, PTP) (3) has been found to specifically bind to Plectin-1 (4, 5), a protein present both inside and on the membrane of human and mouse PDAC cells but only on the inside of normal pancreatic cells. Kelly et al. (3) conjugated PTP to Cy5.5-labeled cross-linked iron oxide particles (CLIO-Cy5.5) for imaging Plectin-1 expression in PDAC, which suggests that Plectin-1 can serve as a biomarker for PDAC. Bausch et al. (2) labeled a tetrameric PTP with 111In (4(βAKTLLPTP-GGS(PEG5000))KKK-111In-DOTA-βA-NH2) (111In-tPTP) for single-photon emission computed tomography (SPECT) imaging for primary and metastatic pancreatic tumors." /><meta name="og:url" content="https://www.ncbi.nlm.nih.gov/books/NBK54202/" /><meta name="og:site_name" content="NCBI Bookshelf" /><meta name="og:image" content="https://www.ncbi.nlm.nih.gov/corehtml/pmc/pmcgifs/bookshelf/thumbs/th-micad-lrg.png" /><meta name="twitter:card" content="summary" /><meta name="twitter:site" content="@ncbibooks" /><meta name="bk-non-canon-loc" content="/books/n/micad/tPTP111In/" /><link rel="canonical" href="https://www.ncbi.nlm.nih.gov/books/NBK54202/" /><link rel="stylesheet" href="/corehtml/pmc/css/figpopup.css" type="text/css" media="screen" /><link rel="stylesheet" href="/corehtml/pmc/css/bookshelf/2.26/css/books.min.css" type="text/css" /><link rel="stylesheet" href="/corehtml/pmc/css/bookshelf/2.26/css/books_print.min.css" type="text/css" media="print" /><style type="text/css">p a.figpopup{display:inline !important} .bk_tt {font-family: monospace} .first-line-outdent .bk_ref {display: inline} .body-content h2, .body-content .h2 {border-bottom: 1px solid #97B0C8} .body-content h2.inline {border-bottom: none} a.page-toc-label , .jig-ncbismoothscroll a {text-decoration:none;border:0 !important} .temp-labeled-list .graphic {display:inline-block !important} .temp-labeled-list img{width:100%}</style><script type="text/javascript" src="/corehtml/pmc/js/jquery.hoverIntent.min.js"> </script><script type="text/javascript" src="/corehtml/pmc/js/common.min.js?_=3.18"> </script><script type="text/javascript" src="/corehtml/pmc/js/large-obj-scrollbars.min.js"> </script><script type="text/javascript">window.name="mainwindow";</script><script type="text/javascript" src="/corehtml/pmc/js/bookshelf/2.26/book-toc.min.js"> </script><script type="text/javascript" src="/corehtml/pmc/js/bookshelf/2.26/books.min.js"> </script><meta name="book-collection" content="NONE" />
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<div class="pre-content"><div><div class="bk_prnt"><p class="small">NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.</p><p>Molecular Imaging and Contrast Agent Database (MICAD) [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2004-2013. </p></div><div class="iconblock clearfix whole_rhythm no_top_margin bk_noprnt"><a class="img_link icnblk_img" title="Table of Contents Page" href="/books/n/micad/"><img class="source-thumb" src="/corehtml/pmc/pmcgifs/bookshelf/thumbs/th-micad-lrg.png" alt="Cover of Molecular Imaging and Contrast Agent Database (MICAD)" height="100px" width="80px" /></a><div class="icnblk_cntnt eight_col"><h2>Molecular Imaging and Contrast Agent Database (MICAD) [Internet].</h2><a data-jig="ncbitoggler" href="#__NBK54202_dtls__">Show details</a><div style="display:none" class="ui-widget" id="__NBK54202_dtls__"><div>Bethesda (MD): <a href="https://www.ncbi.nlm.nih.gov/" ref="pagearea=page-banner&targetsite=external&targetcat=link&targettype=publisher">National Center for Biotechnology Information (US)</a>; 2004-2013.</div></div><div class="half_rhythm"><ul class="inline_list"><li style="margin-right:1em"><a class="bk_cntns" href="/books/n/micad/">Contents</a></li></ul></div><div class="bk_noprnt"><form method="get" action="/books/n/micad/" id="bk_srch"><div class="bk_search"><label for="bk_term" class="offscreen_noflow">Search term</label><input type="text" title="Search this book" id="bk_term" name="term" value="" data-jig="ncbiclearbutton" /> <input type="submit" class="jig-ncbibutton" value="Search this book" submit="false" style="padding: 0.1em 0.4em;" /></div></form></div></div><div class="icnblk_cntnt two_col"><div class="pagination bk_noprnt"><a class="active page_link prev" href="/books/n/micad/H6Met111In/" title="Previous page in this title">< Prev</a><a class="active page_link next" href="/books/n/micad/TrastFab111In/" title="Next page in this title">Next ></a></div></div></div></div></div>
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<div class="main-content lit-style" itemscope="itemscope" itemtype="http://schema.org/CreativeWork"><div class="meta-content fm-sec"><h1 id="_NBK54202_"><span class="title" itemprop="name"><sup>111</sup>In-Tetrameric Plectin-1 targeting peptide (4(βAKTLLPTP-GGS(PEG5000))KKK-<sup>111</sup>In-DOTA-βA-NH<sub>2</sub>)</span></h1><div itemprop="alternativeHeadline" class="subtitle whole_rhythm"><sup>111</sup>In-tPTP</div><p class="contrib-group"><span itemprop="author">Kam Leung</span>, PhD.</p><a data-jig="ncbitoggler" href="#__NBK54202_ai__" style="border:0;text-decoration:none">Author Information and Affiliations</a><div style="display:none" class="ui-widget" id="__NBK54202_ai__"><div class="contrib half_rhythm"><span itemprop="author">Kam Leung</span>, PhD<div class="affiliation small">National Center for Biotechnology Information, NLM, NIH, Bethesda, MD<div><span class="email-label">Email: </span><a href="mailto:dev@null" data-email="vog.hin.mln.ibcn@dacim" class="oemail">vog.hin.mln.ibcn@dacim</a></div></div><div class="small">Corresponding author.</div></div></div><p class="small">Created: <span itemprop="datePublished">January 28, 2011</span>; Last Update: <span itemprop="dateModified">April 27, 2011</span>.</p></div><div class="jig-ncbiinpagenav body-content whole_rhythm" data-jigconfig="allHeadingLevels: ['h2'],smoothScroll: false" itemprop="text"><div id="tPTP111In.T.nc_chemical_name111intetrame" class="table"><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK54202/table/tPTP111In.T.nc_chemical_name111intetrame/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__tPTP111In.T.nc_chemical_name111intetrame_lrgtbl__"><table><tbody><tr><td rowspan="1" colspan="1" style="text-align:right;vertical-align:top;">
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<b>Chemical name:</b>
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</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"><sup>111</sup>In-Tetrameric Plectin-1 targeting peptide (4(βAKTLLPTP-GGS(PEG5000))KKK-<sup>111</sup>In-DOTA-βA-NH<sub>2</sub>)</td><td rowspan="9" colspan="1" style="text-align:center;vertical-align:middle;"></td></tr><tr><td rowspan="1" colspan="1" style="text-align:right;vertical-align:top;">
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<b>Abbreviated name:</b>
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</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"><sup>111</sup>In-tPTP</td></tr><tr><td rowspan="1" colspan="1" style="text-align:right;vertical-align:top;">
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<b>Synonym:</b>
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</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"><sup>111</sup>In-Tetrameric Plectin-1 targeting peptide</td></tr><tr><td rowspan="1" colspan="1" style="text-align:right;vertical-align:top;">
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<b>Agent category:</b>
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</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Peptide</td></tr><tr><td rowspan="1" colspan="1" style="text-align:right;vertical-align:top;">
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<b>Target:</b>
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</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Plectin-1</td></tr><tr><td rowspan="1" colspan="1" style="text-align:right;vertical-align:top;">
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<b>Target category:</b>
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</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Receptor</td></tr><tr><td rowspan="1" colspan="1" style="text-align:right;vertical-align:top;">
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<b>Method of detection:</b>
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</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Single-photon emission computed tomography (SPECT), gamma imaging</td></tr><tr><td rowspan="1" colspan="1" style="text-align:right;vertical-align:top;">
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<b>Source of signal\contrast:</b>
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</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"><sup>111</sup>In</td></tr><tr><td rowspan="1" colspan="1" style="text-align:right;vertical-align:top;">
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<b>Activation:</b>
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</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">No</td></tr><tr><td rowspan="1" colspan="1" style="text-align:right;vertical-align:top;">
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<b>Studies:</b>
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</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<ul class="simple-list"><li class="half_rhythm"><div>
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<img alt="Checkbox" src="/corehtml/pmc/css/bookshelf/2.26/img/studies.checkbox.png" />
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<i>In vitro</i>
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</div></li><li class="half_rhythm"><div>
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<img alt="Checkbox" src="/corehtml/pmc/css/bookshelf/2.26/img/studies.checkbox.png" /> Rodents
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</div></li></ul>
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</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Click on <a href="/entrez/viewer.fcgi?db=protein&id=134044255" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">protein</a>, <a href="/entrez/viewer.fcgi?db=nuccore&id=47607491" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">nucleotide</a> (RefSeq), and <a href="/entrez/query.fcgi?db=gene&cmd=Retrieve&dopt=full_report&list_uids=5339" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">gene</a> for more information about Plectin-1.</td></tr></tbody></table></div></div><div id="tPTP111In.Background"><h2 id="_tPTP111In_Background_">Background</h2><p>[<a href="/entrez/query.fcgi?cmd=PureSearch&db=pubmed&details_term=tPTP" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">PubMed</a>]</p><p>Patients with pancreatic ductal adenocarcinoma (PDAC) have a median survival of 6 months and a 5-year survival rate of only 3% (<a class="bk_pop" href="#tPTP111In.REF.1">1</a>). PDAC is an aggressive cancer with early metastasis in >80% of patients. Early detection would be particularly useful for monitoring people at high risk of developing pancreatic cancer. Plectin-1 was identified in 100% of tested PDAC lesions and 60% of tested preinvasive PanIN III lesions (<a class="bk_pop" href="#tPTP111In.REF.2">2</a>). Plectin-1, a cytoskeletal component, is not expressed in the normal pancreas, liver, lymph node, lung, or peritoneum in humans. Using phage display screenings, the linear peptide Lys-Thr-Leu-Leu-Pro-Thr-Pro (KTLLPTP) (Plectin-1–targeting peptide, PTP) (<a class="bk_pop" href="#tPTP111In.REF.3">3</a>) has been found to specifically bind to Plectin-1 (<a class="bk_pop" href="#tPTP111In.REF.4" data-bk-pop-others="tPTP111In.REF.5">4, 5</a>), a protein present both inside and on the membrane of human and mouse PDAC cells but only on the inside of normal pancreatic cells. Kelly et al. (<a class="bk_pop" href="#tPTP111In.REF.3">3</a>) conjugated PTP to Cy5.5-labeled cross-linked iron oxide particles (CLIO-Cy5.5) for imaging Plectin-1 expression in PDAC, which suggests that Plectin-1 can serve as a biomarker for PDAC. Bausch et al. (<a class="bk_pop" href="#tPTP111In.REF.2">2</a>) labeled a tetrameric PTP with <sup>111</sup>In (4(βAKTLLPTP-GGS(PEG5000))KKK-<sup>111</sup>In-DOTA-βA-NH<sub>2</sub>) (<sup>111</sup>In-tPTP) for single-photon emission computed tomography (SPECT) imaging for primary and metastatic pancreatic tumors.</p><div id="tPTP111In.Related_Resource_Links"><h3>Related Resource Links:</h3><ul><li class="half_rhythm"><div>Chapters in MICAD (<a href="/sites/entrez?Db=books&Cmd=DetailsSearch&Term=Plectin-1%5BAll+Fields%5D+AND+micad%5Bbook%5D" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">Plectin-1</a>)</div></li><li class="half_rhythm"><div>Gene information in NCBI (<a href="/gene/5339" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">Plectin-1</a>).</div></li><li class="half_rhythm"><div>Articles in Online Mendelian Inheritance in Man (OMIM) (<a href="/omim/601282" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">Plectin-1</a>)</div></li></ul></div></div><div id="tPTP111In.Synthesis"><h2 id="_tPTP111In_Synthesis_">Synthesis</h2><p>[<a href="/entrez/query.fcgi?cmd=PureSearch&db=pubmed&details_term=tPTP%20and%20synthesis" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">PubMed</a>]</p><p>4(βAKTLLPTP-GGS(PEG5000))KKK-DOTA-βA-NH<sub>2</sub> (tPTP) (100 µg) was incubated with 185 MBq (5 mCi) <sup>111</sup>InCl<sub>3</sub> in ammonium acetate buffer (pH 4.5) for 15 min at 40°C (<a class="bk_pop" href="#tPTP111In.REF.2">2</a>). <sup>111</sup>In-tPTP was purified with column chromatography. The yield, radiochemical purity, and specific activity of <sup>111</sup>In-tPTP were not reported.</p></div><div id="tPTP111In.In_Vitro_Studies_Testing_in_Ce"><h2 id="_tPTP111In_In_Vitro_Studies_Testing_in_Ce_"><i>In Vitro</i> Studies: Testing in Cells and Tissues</h2><p>[<a href="/entrez/query.fcgi?cmd=PureSearch&db=pubmed&details_term=tPTP%20and%20in%20vitro" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">PubMed</a>]</p><p>Competition binding assays were performed in Plectin-1–positive L3.6pl PDAC cells using <sup>111</sup>In-tPTP with tPTP. tPTP had a <i>K</i><sub>i</sub> value of 830 nM (<a class="bk_pop" href="#tPTP111In.REF.2">2</a>).</p></div><div id="tPTP111In.Animal_Studies"><h2 id="_tPTP111In_Animal_Studies_">Animal Studies</h2><div id="tPTP111In.Rodents"><h3>Rodents</h3><p>[<a href="/entrez/query.fcgi?cmd=PureSearch&db=pubmed&details_term=tPTP%20and%20rodentia" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">PubMed</a>]</p><p>Bausch et al. (<a class="bk_pop" href="#tPTP111In.REF.2">2</a>) performed <i>ex vivo</i> biodistribution studies in mice bearing orthotopically implanted L3.6pl (<i>n</i> = 10), Panc1 (<i>n</i> = 5), or AK134 (<i>n</i> = 8) PDAC tumor cells at 4 h after injection of 37 MBq (1 mCi) <sup>111</sup>In-tPTP. Tumor accumulation of radioactivity was 2.0% injected dose per gram (ID/g), 1.8% ID/g, 1.5% ID/g, and 0.5% ID/g for L3.6pl, Panc1, AK134, and normal pancreas, respectively. Accumulation in these mice was highest in the kidney with 15%–22% ID/g, followed by the liver with 1.7%–2.6% ID/g. Immunohistochemistry of sections of the pancreas and peritoneum metastases confirmed the presence of Plectin-1–expressing tumor cells in the pancreas and peritoneum.</p><p>SPECT scanning clearly visualized the three tumors and the kidneys at 4 h after injection. SPECT scanning located metastases in the peritoneum of two mice, which were confirmed with autopsy. In a model of AK134 PDAC liver metastasis, SPECT/computed tomography scanning clearly identified tumor lesions in the liver, which were confirmed with autopsy.</p></div><div id="tPTP111In.Other_NonPrimate_Mammals"><h3>Other Non-Primate Mammals</h3><p>[<a href="/entrez/query.fcgi?cmd=PureSearch&db=pubmed&details_term=tPTP%20and%20%28dog%20or%20pig%20or%20sheep%20or%20rabbit%29" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">PubMed</a>]</p><p>No publication is currently available.</p></div><div id="tPTP111In.NonHuman_Primates"><h3>Non-Human Primates</h3><p>[<a href="/entrez/query.fcgi?cmd=PureSearch&db=pubmed&details_term=tPTP%20and%20%28primate%20not%20human%29" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">PubMed</a>]</p><p>No publication is currently available.</p></div></div><div id="tPTP111In.Human_Studies"><h2 id="_tPTP111In_Human_Studies_">Human Studies</h2><p>[<a href="/entrez/query.fcgi?cmd=PureSearch&db=pubmed&details_term=tPTP%20and%20human" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">PubMed</a>]</p><p>No publication is currently available.</p></div><div id="tPTP111In.NIH_Support"><h2 id="_tPTP111In_NIH_Support_">NIH Support</h2><p>R01 CA137071-02, R01 CA137071-04, R01 EB010023-01A1, R01 EB010023-02</p></div><div id="tPTP111In.References"><h2 id="_tPTP111In_References_">References</h2><dl class="temp-labeled-list"><dt>1.</dt><dd><div class="bk_ref" id="tPTP111In.REF.1">Li D., Xie K., Wolff R., Abbruzzese J.L.
|
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<em>Pancreatic cancer.</em>
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<span><span class="ref-journal">Lancet. </span>2004;<span class="ref-vol">363</span>(9414):1049–57.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/15051286" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 15051286</span></a>]</div></dd><dt>2.</dt><dd><div class="bk_ref" id="tPTP111In.REF.2">Bausch D., Thomas S., Mino-Kenudson M., Fernandez-del C.C., Bauer T.W., Williams M., Warshaw A.L., Thayer S.P., Kelly K.A.
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<em>Plectin-1 as a novel biomarker for pancreatic cancer.</em>
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<span><span class="ref-journal">Clin Cancer Res. </span>2011;<span class="ref-vol">17</span>(2):302–9.</span> [<a href="/pmc/articles/PMC3044444/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC3044444</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/21098698" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 21098698</span></a>]</div></dd><dt>3.</dt><dd><div class="bk_ref" id="tPTP111In.REF.3">Kelly K.A., Bardeesy N., Anbazhagan R., Gurumurthy S., Berger J., Alencar H., Depinho R.A., Mahmood U., Weissleder R.
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<em>Targeted nanoparticles for imaging incipient pancreatic ductal adenocarcinoma.</em>
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||
<span><span class="ref-journal">PLoS Med. </span>2008;<span class="ref-vol">5</span>(4):e85.</span> [<a href="/pmc/articles/PMC2292750/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC2292750</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/18416599" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 18416599</span></a>]</div></dd><dt>4.</dt><dd><div class="bk_ref" id="tPTP111In.REF.4">Andra K., Kornacker I., Jorgl A., Zorer M., Spazierer D., Fuchs P., Fischer I., Wiche G.
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<em>Plectin-isoform-specific rescue of hemidesmosomal defects in plectin (-/-) keratinocytes.</em>
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||
<span><span class="ref-journal">J Invest Dermatol. </span>2003;<span class="ref-vol">120</span>(2):189–97.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/12542521" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 12542521</span></a>]</div></dd><dt>5.</dt><dd><div class="bk_ref" id="tPTP111In.REF.5">Sonnenberg A., Liem R.K.
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<em>Plakins in development and disease.</em>
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<span><span class="ref-journal">Exp Cell Res. </span>2007;<span class="ref-vol">313</span>(10):2189–203.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/17499243" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 17499243</span></a>]</div></dd></dl></div><div id="bk_toc_contnr"></div></div></div>
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<div class="post-content"><div><div class="half_rhythm"><a href="/books/about/copyright/">Copyright Notice</a></div><div class="small"><span class="label">Bookshelf ID: NBK54202</span><span class="label">PMID: <a href="https://pubmed.ncbi.nlm.nih.gov/21542555" title="PubMed record of this page" ref="pagearea=meta&targetsite=entrez&targetcat=link&targettype=pubmed">21542555</a></span></div><div style="margin-top:2em" class="bk_noprnt"><a class="bk_cntns" href="/books/n/micad/">Contents</a><div class="pagination bk_noprnt"><a class="active page_link prev" href="/books/n/micad/H6Met111In/" title="Previous page in this title">< Prev</a><a class="active page_link next" href="/books/n/micad/TrastFab111In/" title="Next page in this title">Next ></a></div></div></div></div>
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<div xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"></div><div class="portlet"><div class="portlet_head"><div class="portlet_title"><h3><span>Views</span></h3></div><a name="Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="PDF_download" id="Shutter"></a></div><div class="portlet_content"><ul xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="simple-list"><li><a href="/books/NBK54202/?report=reader">PubReader</a></li><li><a href="/books/NBK54202/?report=printable">Print View</a></li><li><a data-jig="ncbidialog" href="#_ncbi_dlg_citbx_NBK54202" data-jigconfig="width:400,modal:true">Cite this Page</a><div id="_ncbi_dlg_citbx_NBK54202" style="display:none" title="Cite this Page"><div class="bk_tt">Leung K. 111In-Tetrameric Plectin-1 targeting peptide (4(βAKTLLPTP-GGS(PEG5000))KKK-111In-DOTA-βA-NH2) 2011 Jan 28 [Updated 2011 Apr 27]. In: Molecular Imaging and Contrast Agent Database (MICAD) [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2004-2013. <span class="bk_cite_avail"></span></div></div></li><li><a href="/books/NBK54202/pdf/Bookshelf_NBK54202.pdf">PDF version of this page</a> (371K)</li><li><a href="/books/n/micad/toc/bin/micad.csv">MICAD summary (CSV file)</a></li></ul></div></div><div class="portlet"><div class="portlet_head"><div class="portlet_title"><h3><span>In this page</span></h3></div><a name="Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="page-toc" id="Shutter"></a></div><div class="portlet_content"><ul xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="simple-list"><li><a href="#tPTP111In.Background" ref="log$=inpage&link_id=inpage">Background</a></li><li><a href="#tPTP111In.Synthesis" ref="log$=inpage&link_id=inpage">Synthesis</a></li><li><a href="#tPTP111In.In_Vitro_Studies_Testing_in_Ce" ref="log$=inpage&link_id=inpage"><i>In Vitro</i> Studies: Testing in Cells and Tissues</a></li><li><a href="#tPTP111In.Animal_Studies" ref="log$=inpage&link_id=inpage">Animal Studies</a></li><li><a href="#tPTP111In.Human_Studies" ref="log$=inpage&link_id=inpage">Human Studies</a></li><li><a href="#tPTP111In.NIH_Support" ref="log$=inpage&link_id=inpage">NIH Support</a></li><li><a href="#tPTP111In.References" ref="log$=inpage&link_id=inpage">References</a></li></ul></div></div><div class="portlet"><div class="portlet_head"><div class="portlet_title"><h3><span>Search MICAD</span></h3></div><a name="Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="source-application" id="Shutter"></a></div><div class="portlet_content"><form xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" name="frmSearch" method="get" action="/books/NBK5330/" id="frmSearch"><script type="text/javascript" src="/corehtml/pmc//js/bookshelf/micad.js">/**/</script><label class="offscreen_noflow" for="txtfield">Search term</label><input id="txtfield" type="text" name="f1_term" size="22" onKeyPress="KeyPress('micad',event,'/books/NBK5330/','')" /><button name="f1_search" type="submit">Go</button><button onclick="this.form.reset();" type="reset">Clear</button><p><b>Limit my Search:</b></p><div class="clearfix"><label for="detection">Method of detection:</label><div class="right"><select name="detection" id="detection" style="width:200px"><option value="" selected="selected">Any</option><option value="(MRI OR "Magnetic resonance imaging" OR MRS)">MRI</option><option value="Multimodal">Multimodal imaging</option><option value="Optical">Optical imaging</option><option value="PET">PET</option><option value="Photoacoustic">Photoacoustic imaging</option><option value="(SPECT OR planar)">SPECT</option><option value="Ultrasound">Ultrasound</option><option value="(x-ray OR ct)">X-ray, CT</option></select></div></div><div class="clearfix"><label for="signal">Source of signal/contrast:</label><div class="right"><select name="signal" id="signal" style="width:200px"><option value="" selected="selected">Any</option><optgroup label="MRI agents"><option value="(Copper OR Cu)">Copper</option><option value="(Europium OR Eu3+)">Europium</option><option value="(Fluorine OR 19F)">Fluorine</option><option value="(Gadolinium OR Gd3+)">Gadolinium</option><option value=""Hyperpolarized 13C"">Hyperpolarized 13C</option><option value=""Iron oxide"">Iron oxide</option><option value=""Nitroxide radicals"">Nitroxide radicals</option><option value="(Oxygen OR 17O)">Oxygen</option><option value="Thulium">Thulium</option></optgroup><optgroup label="Multimodal agents"><option value="((Gadolinium OR Gd3+) AND Optical)">Gadolinium and optical</option><option value="((Gadolinium OR Gd3+) AND (Gold OR Au))">Gadolinium and Gold</option><option value="("Iron oxide" AND (64Cu OR 124I OR 111In))">Iron oxide and
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europium</option><option value="(166Ho OR 67Ga OR 68Ga OR 123I OR 124I OR 125I)">Radionuclides</option></optgroup><optgroup label="Optical agents"><option value="("Fluorescent dyes" OR protein)">Fluorescent dyes or proteins</option><option value=""Luminescent agents"">Luminescent agents</option><option value="(Metals OR Metal OR Gold OR Au)">Metals (Au)</option><option value="Nanotubes">Nanotubes</option><option value=""Quantum dots"">Quantum dots</option></optgroup><optgroup label="PET radionuclides"><option value="("Arsenic 74" OR 74As)">Arsenic-74</option><option value="("Bromine 76" OR 76Br)">Bromine-76</option><option value="("Carbon 11" OR 11C)">Carbon-11</option><option value="(Copper-60 OR Copper-61 OR Copper-62 OR Copper-64 OR 60Cu OR 61Cu OR 62Cu OR 64Cu)">Copper-60, 61, 62, 64</option><option value="("Fluorine 18" OR 18F)">Fluorine-18</option><option value="(Gallium-68 OR 68Ga)">Gallium-68</option><option value="("Iodine 124" OR 124I)">Iodine-124</option><option value="("Nitrogen 13" OR 13N)">Nitrogen-13</option><option value="("Yttrium 86" OR 86Y)">Yttrium-86</option><option value="("Zirconium 89" OR 89Zr)">Zirconium-89</option></optgroup><optgroup label="Photoacoustic agents"><option value="(Gold OR Au)">Gold</option><option value="("Indocyanine green" OR ICG)">Indocyanine green</option></optgroup><optgroup label="SPECT radionuclides"><option value="(Gallium-67 OR 67Ga)">Gallium-67</option><option value="("Indium 111" OR 111In)">Indium-111</option><option value="("Iodine 123" OR "Iodine 125" OR "Iodine 131" OR 123I OR 125I OR 131I)">Iodine-123, 125, 131</option><option value="("Lutetium 177" OR 177Lu)">Lutetium-177</option><option value="(Rhenium OR 186Re OR 188Re)">Rhenium</option><option value="("Technetium 99m" OR 99mTc)">Technetium-99m</option><option value="("Tellurium 125m" OR 125mTe)">Tellurium-125m</option></optgroup><optgroup label="Ultrasound agents"><option value="Microbubbles">Microbubbles</option><option value="Nanobubbles">Nanobubbles</option></optgroup><optgroup label="X-ray and CT agents"><option value="(Bismuth OR Bi)">Bismuth</option><option value="(Gold OR Au)">Gold</option><option value="Iodine">Iodine</option></optgroup></select></div></div><div class="clearfix"><label for="agent">Agent Category:</label><div class="right"><select name="agent" id="agent" style="width:200px"><option value="" selected="selected">Any</option><option value="(antibody OR trastuzumab OR immunoglobulin)">Antibodies</option><option value="(bacteria OR bacteriophage OR coli)">Bacteria</option><option value="cell">Cells</option><option value="(compound OR "amino acid" OR "folic acid" OR "cage molecule" OR carbohydrate OR copolymers OR polymer OR "small molecule" OR macromolecule OR triiodobenzoate OR estradiol OR glycosaminoglycan)">Compounds</option><option value="ligand">Ligands</option><option value="(lipid OR liposome OR liposomes">Lipids</option><option value="metal">Metal</option><option 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receptor-antibody OR antibody-receptor)">Receptors</option><option value="transporter">Transporters</option><option value="non-targeted">Non-targeted</option><option value=""nucleic acid"">Nucleic acids</option><option value="(non-targeted OR "unknown binding site")">Others</option></select></div></div><div><input id="__micad_btn_1" type="radio" name="stage" value="vitro" /><label for="__micad_btn_1"><i>In vitro</i></label><input id="__micad_btn_2" type="radio" name="stage" value="rodents" /><label for="__micad_btn_2">Rodents</label><input id="__micad_btn_3" type="radio" name="stage" value="mammals" /><label for="__micad_btn_3">Non-primate non-rodent mammals</label><br /><input id="__micad_btn_4" type="radio" name="stage" value="primates" /><label for="__micad_btn_4">Non-human primates</label><input id="__micad_btn_5" type="radio" name="stage" value="humans" /><label for="__micad_btn_5">Humans</label><input id="__micad_btn_6" type="radio" name="stage" value="any" checked="checked" /><label for="__micad_btn_6">Any</label></div></form><form xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" name="frmGo" method="get" action="javascript:alert('frmGo:_@action_was_not_set')" id="frmGo"><input name="term" value="." type="hidden" /></form></div></div><div class="portlet"><div class="portlet_head"><div class="portlet_title"><h3><span>Related information</span></h3></div><a name="Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="discovery_db_links" id="Shutter"></a></div><div class="portlet_content"><ul><li class="brieflinkpopper"><a class="brieflinkpopperctrl" href="/books/?Db=pmc&DbFrom=books&Cmd=Link&LinkName=books_pmc_refs&IdsFromResult=2455020" ref="log$=recordlinks">PMC</a><div class="brieflinkpop offscreen_noflow">PubMed Central citations</div></li><li class="brieflinkpopper"><a class="brieflinkpopperctrl" href="/books/?Db=pubmed&DbFrom=books&Cmd=Link&LinkName=books_pubmed_refs&IdsFromResult=2455020" ref="log$=recordlinks">PubMed</a><div class="brieflinkpop offscreen_noflow">Links to PubMed</div></li></ul></div></div><div class="portlet"><div class="portlet_head"><div class="portlet_title"><h3><span>Similar articles in PubMed</span></h3></div><a name="Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="PBooksDiscovery_RA" id="Shutter"></a></div><div class="portlet_content"><ul><li class="brieflinkpopper two_line"><a class="brieflinkpopperctrl" href="/pubmed/20641636" ref="ordinalpos=1&linkpos=1&log$=relatedreviews&logdbfrom=pubmed"><span xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="invert">Review</span> Lys-Thr-Leu-Leu-Pro-Thr-Pro-cross-linked iron oxide-Cy5.5.</a><span class="source">[Molecular Imaging and Contrast...]</span><div class="brieflinkpop 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