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<div class="pre-content"><div><div class="bk_prnt"><p class="small">NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.</p><p>Molecular Imaging and Contrast Agent Database (MICAD) [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2004-2013. </p></div><div class="iconblock clearfix whole_rhythm no_top_margin bk_noprnt"><a class="img_link icnblk_img" title="Table of Contents Page" href="/books/n/micad/"><img class="source-thumb" src="/corehtml/pmc/pmcgifs/bookshelf/thumbs/th-micad-lrg.png" alt="Cover of Molecular Imaging and Contrast Agent Database (MICAD)" height="100px" width="80px" /></a><div class="icnblk_cntnt eight_col"><h2>Molecular Imaging and Contrast Agent Database (MICAD) [Internet].</h2><a data-jig="ncbitoggler" href="#__NBK57131_dtls__">Show details</a><div style="display:none" class="ui-widget" id="__NBK57131_dtls__"><div>Bethesda (MD): <a href="https://www.ncbi.nlm.nih.gov/" ref="pagearea=page-banner&targetsite=external&targetcat=link&targettype=publisher">National Center for Biotechnology Information (US)</a>; 2004-2013.</div></div><div class="half_rhythm"><ul class="inline_list"><li style="margin-right:1em"><a class="bk_cntns" href="/books/n/micad/">Contents</a></li></ul></div><div class="bk_noprnt"><form method="get" action="/books/n/micad/" id="bk_srch"><div class="bk_search"><label for="bk_term" class="offscreen_noflow">Search term</label><input type="text" title="Search this book" id="bk_term" name="term" value="" data-jig="ncbiclearbutton" /> <input type="submit" class="jig-ncbibutton" value="Search this book" submit="false" style="padding: 0.1em 0.4em;" /></div></form></div></div><div class="icnblk_cntnt two_col"><div class="pagination bk_noprnt"><a class="active page_link prev" href="/books/n/micad/EGFR-Fab125I/" title="Previous page in this title">< Prev</a><a class="active page_link next" href="/books/n/micad/Peptides125I/" title="Next page in this title">Next ></a></div></div></div></div></div>
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<div class="main-content lit-style" itemscope="itemscope" itemtype="http://schema.org/CreativeWork"><div class="meta-content fm-sec"><h1 id="_NBK57131_"><span class="title" itemprop="name"><sup>125</sup>I-Labeled anti-mucin 1 bispecific antibody bsPAM4</span></h1><div itemprop="alternativeHeadline" class="subtitle whole_rhythm"> [<sup>125</sup>I]-bsPAM4</div><p class="contrib-group"><span itemprop="author">Arvind Chopra</span>, PhD.</p><a data-jig="ncbitoggler" href="#__NBK57131_ai__" style="border:0;text-decoration:none">Author Information and Affiliations</a><div style="display:none" class="ui-widget" id="__NBK57131_ai__"><div class="contrib half_rhythm"><span itemprop="author">Arvind Chopra</span>, PhD<div class="affiliation small">National Center for Biotechnology Information, NLM, Bethesda, MD 20894<div><span class="email-label">Email: </span><a href="mailto:dev@null" data-email="vog.hin.mln.ibcn@dacim" class="oemail">vog.hin.mln.ibcn@dacim</a></div></div></div></div><p class="small">Created: <span itemprop="datePublished">June 22, 2011</span>; Last Update: <span itemprop="dateModified">July 26, 2011</span>.</p></div><div class="jig-ncbiinpagenav body-content whole_rhythm" data-jigconfig="allHeadingLevels: ['h2'],smoothScroll: false" itemprop="text"><div id="bsPAM4125I.T.nc_chemical_name125ilabeled" class="table"><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK57131/table/bsPAM4125I.T.nc_chemical_name125ilabeled/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__bsPAM4125I.T.nc_chemical_name125ilabeled_lrgtbl__"><table><tbody><tr><td rowspan="1" colspan="1" style="text-align:right;vertical-align:top;">
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<b>Chemical name:</b>
|
||
</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">[<sup>125</sup>I]-Labeled anti-mucin 1 bispecific antibody bsPAM4</td><td rowspan="9" colspan="1" style="text-align:center;vertical-align:middle;"></td></tr><tr><td rowspan="1" colspan="1" style="text-align:right;vertical-align:top;">
|
||
<b>Abbreviated name:</b>
|
||
</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">[<sup>125</sup>I]-bsPAM4</td></tr><tr><td rowspan="1" colspan="1" style="text-align:right;vertical-align:top;">
|
||
<b>Synonym:</b>
|
||
</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td></tr><tr><td rowspan="1" colspan="1" style="text-align:right;vertical-align:top;">
|
||
<b>Agent Category:</b>
|
||
</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Antibody</td></tr><tr><td rowspan="1" colspan="1" style="text-align:right;vertical-align:top;">
|
||
<b>Target:</b>
|
||
</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Mucin 1 (MUC1)</td></tr><tr><td rowspan="1" colspan="1" style="text-align:right;vertical-align:top;">
|
||
<b>Target Category:</b>
|
||
</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Antigen</td></tr><tr><td rowspan="1" colspan="1" style="text-align:right;vertical-align:top;">
|
||
<b>Method of detection:</b>
|
||
</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Single-photon emission computed tomography (SPECT); gamma planar imaging</td></tr><tr><td rowspan="1" colspan="1" style="text-align:right;vertical-align:top;">
|
||
<b>Source of signal / contrast:</b>
|
||
</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"><sup>125</sup>I</td></tr><tr><td rowspan="1" colspan="1" style="text-align:right;vertical-align:top;">
|
||
<b>Activation:</b>
|
||
</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">No</td></tr><tr><td rowspan="1" colspan="1" style="text-align:right;vertical-align:top;">
|
||
<b>Studies:</b>
|
||
</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<ul class="simple-list"><li class="half_rhythm"><div>
|
||
<img alt="Checkbox" src="/corehtml/pmc/css/bookshelf/2.26/img/studies.checkbox.png" />
|
||
<i>In vitro</i>
|
||
|
||
</div></li><li class="half_rhythm"><div>
|
||
<img alt="Checkbox" src="/corehtml/pmc/css/bookshelf/2.26/img/studies.checkbox.png" /> Rodents
|
||
</div></li></ul>
|
||
</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Structure not available in <a href="http://pubchem.ncbi.nlm.nih.gov/" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">PubChem</a>.</td></tr></tbody></table></div></div><div id="bsPAM4125I.Background"><h2 id="_bsPAM4125I_Background_">Background</h2><p>[<a href="/pubmed?term=PAM4&cmd=DetailsSearch" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">PubMed</a>]</p><p>The majority of individuals suffering from pancreatic adenocarcinoma (PAC) do not survive for more than 1 year after diagnosis, and <1% of these patients live beyond 5 years (<a class="bk_pop" href="#bsPAM4125I.REF.1">1</a>). Although surgical resection of the cancer is a possible intervention for this disease, only 10%–25% of the patients are considered suitable for this treatment because, by the time that the neoplasm is detected, the malignancy has metastasized to other organs and the tumor load in the patient is too high to warrant surgery (<a class="bk_pop" href="#bsPAM4125I.REF.2">2</a>). Patients with nonresectable PAC are treated either with <a href="http://www.cancer.gov/cancertopics/druginfo/gemcitabinehydrochloride" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">gemcitabine</a> or radiotherapy or a combination of the two; however, these treatments are not curative because they only prolong survival and improve the quality of life of the patient (<a class="bk_pop" href="#bsPAM4125I.REF.2">2</a>). The detection of this invasive cancer at an early stage would facilitate proper staging of the disease so that a suitable treatment regimen can be initiated to possibly improve patient prognosis (<a class="bk_pop" href="#bsPAM4125I.REF.3">3</a>).</p><p>In this regard, the monoclonal antibody (mAb) PAM4, which specifically targets mucin 1 (MUC1), a glycoprotein that is overexpressed only in PAC tumors, was developed, radiolabeled with <sup>131</sup>I or <sup>111</sup>In, and shown to detect neoplastic tumors with scintigraphy in patients having pancreatic malignancies (<a class="bk_pop" href="#bsPAM4125I.REF.4">4</a>). However, intact radiolabeled antibodies are known to have limited tumor penetration due to their large size (~150 kDa) and are of limited utility to visualize cancerous lesions with different imaging modalities (primarily positron emission tomography and single-photon emission computed tomography) due to their long circulating half-life (<a class="bk_pop" href="#bsPAM4125I.REF.5">5</a>). To amplify the signal obtained from an imaging agent that can be used to detect malignant tumors noninvasively, investigators have developed and evaluated a variety of strategies in preclinical studies in animals, such as pretargeting the cancer lesion with a suitable mAb (or its derivative) followed by exposing the animals to an appropriate radiolabeled, small molecular weight ligand that targets the mAb or its derivative. This technique has been shown to generate higher signal/noise ratios during imaging compared to ratios obtained with a directly labeled mAb alone (<a class="bk_pop" href="#bsPAM4125I.REF.6" data-bk-pop-others="bsPAM4125I.REF.7 bsPAM4125I.REF.8">6-8</a>). Use of the pretargeting technique for the imaging and therapy of cancer has been discussed in detail elsewhere (<a class="bk_pop" href="#bsPAM4125I.REF.9" data-bk-pop-others="bsPAM4125I.REF.10">9, 10</a>).</p><p>Cardillo et al. developed bsPAM4 (or bsmAb), a bispecific F(ab’)<sub>2</sub> mAb fragment, by cross-linking a PAM4 Fab’ fragment to a murine anti—indium-diethylenetriamine pentaacetic acid (DTPA) mAb Fab’ fragment and using the unlabeled bsPAM4 to pretarget human CaPan-1 cell xenograft PAC tumors in nude mice (<a class="bk_pop" href="#bsPAM4125I.REF.4">4</a>). The animals were exposed to two radiolabeled peptide haptens, <sup>111</sup>In-labeled Ac-Phe-Lys(DTPA)-Tyr-Lys(DTPA)-NH<sub>2</sub> ([<sup>111</sup>In]-IMP-156) and <sup>99</sup>Tc-labeled Ac-Lys(DTPA)-Tyr-Lys(DTPA)-Lys(thiosemicarbazonyl-glyoxyl-cysteinyl-)-NH<sub>2</sub> ([<sup>99m</sup>Tc]-IMP-192), respectively, that bind specifically to the anti-indium-DTPA mAb Fab’ fragment arm of the bsmAb. To confirm the tumor-targeting specificity of bsPAM4, the biodistribution of <sup>125</sup>I-labeled bsPAM4 ([<sup>125</sup>I]-bsPAM4) was investigated in a group of mice bearing human PAC tumors and the results are presented in this chapter (<a class="bk_pop" href="#bsPAM4125I.REF.4">4</a>). The biodistribution studies performed with [<sup>111</sup>In]-IMP-156 (<a class="bk_pop" href="#bsPAM4125I.REF.11">11</a>) and [<sup>99m</sup>Tc]-IMP-192 (<a class="bk_pop" href="#bsPAM4125I.REF.12">12</a>) in mice bearing human PAC tumors pretargeted with bsPAM4 are discussed in separate chapters of MICAD (<a href="http://www.micad.nih.gov/" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">www.micad.nih.gov</a>).</p><div id="bsPAM4125I.Other_Sources_of_Information"><h3>Other Sources of Information</h3><p>Peptide haptens [<a href="/pubmed?term=peptide%20haptens&cmd=DetailsSearch" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">PubMed</a>]</p><p><a href="http://clinicaltrials.gov/ct2/results?term=bispecific+antibody" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">Clinical trials</a> with bispecific antibodies</p><p>Application of multivalent antibodies [<a href="/pubmed?term=application%20of%20multivalent%20antibodies&cmd=DetailsSearch" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">PubMed</a>]</p></div></div><div id="bsPAM4125I.Synthesis"><h2 id="_bsPAM4125I_Synthesis_">Synthesis</h2><p>[<a href="/pubmed?term=125I-bsPAM4%20synthesis&cmd=DetailsSearch" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">PubMed</a>]</p><p>The synthesis methods for bsPAM4 and bispecific rituximab (bsRIT) for use as a control were described by Cardillo et al. (<a class="bk_pop" href="#bsPAM4125I.REF.4">4</a>). The cross-linked bsmAbs were purified with size-exclusion chromatography (SEC), and the ratio of each Fab’ fragment in the complex was determined with high-performance liquid chromatography to be 1:1. The bsmAbs were labeled with <sup>125</sup>I (bsPAM4) or <sup>131</sup>I (bsRIT) with the chloramine-T method to obtain [<sup>125</sup>I]-bsPAM4 and [<sup>131</sup>I]-bsRIT (<a class="bk_pop" href="#bsPAM4125I.REF.4">4</a>). [<sup>125</sup>I]-bsPAM4 and [<sup>131</sup>I]-bsRIT were reported to have specific activities of 488 MBq/mg (13.2 mCi/mg) and 103 MBq/mg (2.8 mCi/mg), respectively. The radiochemical purity and yield of the radioiodinated bsmAbs were not reported.</p></div><div id="bsPAM4125I.In_Vitro_Studies_Testing_in_C"><h2 id="_bsPAM4125I_In_Vitro_Studies_Testing_in_C_"><i>In Vitro</i> Studies: Testing in Cells and Tissues</h2><p>[<a href="/pubmed?term=125I-bsPAM4%20in%20vitro&cmd=DetailsSearch" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">PubMed</a>]</p><p>Both bsPAM4 and bsRIT were reported to be stable in mouse serum and showed no aggregation or degradation for at least 5 days (incubation temperature not provided) as determined with SEC (<a class="bk_pop" href="#bsPAM4125I.REF.4">4</a>).</p></div><div id="bsPAM4125I.Animal_Studies"><h2 id="_bsPAM4125I_Animal_Studies_">Animal Studies</h2><div id="bsPAM4125I.Rodents"><h3>Rodents</h3><p>[<a href="/pubmed?term=125I-bsPAM4%20rodentia&cmd=DetailsSearch" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">PubMed</a>]</p><p>The biodistribution of [<sup>125</sup>I]-bsPAM4 was investigated in athymic <i>nu/nu</i> mice bearing human PAC CaPan-1 cell tumors (<a class="bk_pop" href="#bsPAM4125I.REF.4">4</a>). The animals (<i>n</i> = 5 mice/group) were coinjected with 370 kBq/150 pmol (10 μCi/150 pmol) [<sup>125</sup>I]-bsPAM4 or 1.3 MBq/150 pmol (35 μCi/150 pmol) [<sup>131</sup>I]-bsRIT and euthanized at predetermined time points varying from 4 h to 72 h postinjection (p.i.). All organs of interest, including the tumors, were removed, and the amount of radioactivity accumulated in the various tissues was determined. Data obtained from this study were presented as percent of injected dose per gram tissue (% ID/g).</p><p>The amount of radioactivity in the tumor from [<sup>125</sup>I]-bsPAM4 was reported to be significantly higher (<i>P</i> = 0.0320–0.0098) than that from [<sup>131</sup>I]-bsRIT at all time points (<a class="bk_pop" href="#bsPAM4125I.REF.4">4</a>). With [<sup>125</sup>I]-bsPAM4, the amount of radioactivity detected in the tumor was 6.43 ± 1.50% ID/g and 5.37 ± 2.38% ID/g at 36 h and 48 h p.i., respectively, which was significantly higher than the accumulation with the <sup>131</sup>I-labeled control bsmAb (0.65 ± 0.33% ID/g and 0.47 ± 0.19% ID/g, at 36 h and 48 h p.i., respectively) (<i>P</i> = 0.0180 and 0.0098 at the respective time points). Although the blood clearance rates of both the radioiodinated bsmAbs were for the most part very similar, the uptake of label from [<sup>125</sup>I]-bsPAM4 in the non-tumor tissues was significantly higher than that observed with [<sup>131</sup>I]-bsRIT; e.g., at 24 h p.i., uptake in the spleen was 0.66 ± 0.06% ID/g with [<sup>125</sup>I]-bsPAM4 <i>versus</i> 0.52 ± 0.02% ID/g (<i>P</i> = 0.0412) with [<sup>131</sup>I]-bsRIT, and uptake in the muscle at the same time point was 0.30 ± 0.04% ID/g for [<sup>125</sup>I]-bsPAM4 <i>versus</i> 0.19 ± 0.02% ID/g (<i>P</i> = 0.0169) with [<sup>131</sup>I]-bsRIT, etc.</p><p>From these studies, the investigators concluded that bsPAM4 was suitable to target PAC xenograft tumors in rodents and could be used for the pretargeting studies with [<sup>111</sup>In]-IMP-156 and [<sup>99m</sup>Tc]-IMP-192 (<a class="bk_pop" href="#bsPAM4125I.REF.4">4</a>).</p></div><div id="bsPAM4125I.Other_NonPrimate_Mammals"><h3>Other Non-Primate Mammals</h3><p>[<a href="/pubmed?term=%5B125I%5D-PAM4%20Non-Primate%20Mammals&cmd=DetailsSearch" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">PubMed</a>]</p><p>No publication is currently available.</p></div><div id="bsPAM4125I.NonHuman_Primates"><h3>Non-Human Primates</h3><p>[<a href="/pubmed?term=%5B125I%5D-PAM4%20Non-Human%20Primates&cmd=DetailsSearch" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">PubMed</a>]</p><p>No publication is currently available.</p></div></div><div id="bsPAM4125I.Human_Studies"><h2 id="_bsPAM4125I_Human_Studies_">Human Studies</h2><p>[<a href="/pubmed?term=%5B125I%5D-PAM4%20Human%20Studies&cmd=DetailsSearch" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">PubMed</a>]</p><p>No publication is currently available.</p></div><div id="bsPAM4125I.Supplemental_Information"><h2 id="_bsPAM4125I_Supplemental_Information_">Supplemental Information</h2><p>[<a href="/books/n/micad/disclaimer/">Disclaimers</a>]</p><p>No information is currently available.</p></div><div id="bsPAM4125I.NIH_Support"><h2 id="_bsPAM4125I_NIH_Support_">NIH Support</h2><p>Studies described in this chapter were supported by National Institutes of Health grants CA-54425 and CA92723.</p></div><div id="bsPAM4125I.References"><h2 id="_bsPAM4125I_References_">References</h2><dl class="temp-labeled-list"><dt>1.</dt><dd><div class="bk_ref" id="bsPAM4125I.REF.1">Gold D.V., Goldenberg D.M., Karacay H., Rossi E.A., Chang C.H., Cardillo T.M., McBride W.J., Sharkey R.M.
|
||
<em>A novel bispecific, trivalent antibody construct for targeting pancreatic carcinoma.</em>
|
||
<span><span class="ref-journal">Cancer Res. </span>2008;<span class="ref-vol">68</span>(12):4819–26.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/18559529" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 18559529</span></a>]</div></dd><dt>2.</dt><dd><div class="bk_ref" id="bsPAM4125I.REF.2">Gold D.V., Cardillo T., Goldenberg D.M., Sharkey R.M.
|
||
<em>Localization of pancreatic cancer with radiolabeled monoclonal antibody PAM4.</em>
|
||
<span><span class="ref-journal">Crit Rev Oncol Hematol. </span>2001;<span class="ref-vol">39</span>(1-2):147–54.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/11418312" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 11418312</span></a>]</div></dd><dt>3.</dt><dd><div class="bk_ref" id="bsPAM4125I.REF.3">Gold D.V., Goggins M., Modrak D.E., Newsome G., Liu M., Shi C., Hruban R.H., Goldenberg D.M.
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||
<em>Detection of early-stage pancreatic adenocarcinoma.</em>
|
||
<span><span class="ref-journal">Cancer Epidemiol Biomarkers Prev. </span>2010;<span class="ref-vol">19</span>(11):2786–94.</span> [<a href="/pmc/articles/PMC2976815/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC2976815</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/20810605" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 20810605</span></a>]</div></dd><dt>4.</dt><dd><div class="bk_ref" id="bsPAM4125I.REF.4">Cardillo T.M., Karacay H., Goldenberg D.M., Yeldell D., Chang C.H., Modrak D.E., Sharkey R.M., Gold D.V.
|
||
<em>Improved targeting of pancreatic cancer: experimental studies of a new bispecific antibody, pretargeting enhancement system for immunoscintigraphy.</em>
|
||
<span><span class="ref-journal">Clin Cancer Res. </span>2004;<span class="ref-vol">10</span>(10):3552–61.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/15161715" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 15161715</span></a>]</div></dd><dt>5.</dt><dd><div class="bk_ref" id="bsPAM4125I.REF.5">Ahlgren S., Orlova A., Wallberg H., Hansson M., Sandstrom M., Lewsley R., Wennborg A., Abrahmsen L., Tolmachev V., Feldwisch J.
|
||
<em>Targeting of HER2-expressing tumors using 111In-ABY-025, a second-generation affibody molecule with a fundamentally reengineered scaffold.</em>
|
||
<span><span class="ref-journal">J Nucl Med. </span>2010;<span class="ref-vol">51</span>(7):1131–8.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/20554729" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 20554729</span></a>]</div></dd><dt>6.</dt><dd><div class="bk_ref" id="bsPAM4125I.REF.6">Forster G.J., Santos E.B., Smith-Jones P.M., Zanzonico P., Larson S.M.
|
||
<em>Pretargeted radioimmunotherapy with a single-chain antibody/streptavidin construct and radiolabeled DOTA-biotin: strategies for reduction of the renal dose.</em>
|
||
<span><span class="ref-journal">J Nucl Med. </span>2006;<span class="ref-vol">47</span>(1):140–9.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/16391198" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 16391198</span></a>]</div></dd><dt>7.</dt><dd><div class="bk_ref" id="bsPAM4125I.REF.7">Liu G., Dou S., Pretorius P.H., Liu X., Chen L., Rusckowski M., Hnatowich D.J.
|
||
<em>Tumor pretargeting in mice using MORF conjugated CC49 antibody and radiolabeled complimentary cMORF effector.</em>
|
||
<span><span class="ref-journal">Q J Nucl Med Mol Imaging. </span>2010;<span class="ref-vol">54</span>(3):333–40.</span> [<a href="/pmc/articles/PMC2939249/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC2939249</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/20639818" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 20639818</span></a>]</div></dd><dt>8.</dt><dd><div class="bk_ref" id="bsPAM4125I.REF.8">Uppal J.K., Varshney R., Hazari P.P., Chuttani K., Kaushik N.K., Mishra A.K.
|
||
<em>Biological evaluation of avidin-based tumor pretargeting with DOTA-Triazole-Biotin constructed via versatile Cu(I) catalyzed click chemistry.</em>
|
||
<span><span class="ref-journal">J Drug Target. </span>2011;<span class="ref-vol">19</span>(6):418–26.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/20678008" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 20678008</span></a>]</div></dd><dt>9.</dt><dd><div class="bk_ref" id="bsPAM4125I.REF.9">Goldenberg D.M., Sharkey R.M.
|
||
<em>Radioactive antibodies: a historical review of selective targeting and treatment of cancer.</em>
|
||
<span><span class="ref-journal">Hosp Pract (Minneap). </span>2010;<span class="ref-vol">38</span>(5):82–93.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/20890056" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 20890056</span></a>]</div></dd><dt>10.</dt><dd><div class="bk_ref" id="bsPAM4125I.REF.10">Sharkey R.M., Goldenberg D.M.
|
||
<em>Cancer radioimmunotherapy.</em>
|
||
<span><span class="ref-journal">Immunotherapy. </span>2011;<span class="ref-vol">3</span>(3):349–70.</span> [<a href="/pmc/articles/PMC3123828/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC3123828</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/21395378" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 21395378</span></a>]</div></dd><dt>11.</dt><dd><div class="bk_ref" id="bsPAM4125I.REF.11">Chopra, A., <em>111In-labeled Ac-Phe-Lys(DTPA)-Tyr-Lys(DTPA)-NH2 (IMP-156).</em> Molecular Imaging and Contrast agent Database (MICAD) [database online]. National Library of Medicine, NCBI, Bethesda, MD, USA. Available from <a href="http://www.micad.nih.gov/" ref="pagearea=cite-ref&targetsite=external&targetcat=link&targettype=uri">www<wbr style="display:inline-block"></wbr>.micad.nih.gov</a>, 2004 -to current. [<a href="https://pubmed.ncbi.nlm.nih.gov/21834179" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 21834179</span></a>]</div></dd><dt>12.</dt><dd><div class="bk_ref" id="bsPAM4125I.REF.12">Chopra, A., <em>99mTc-Ac-Lys(DTPA)-Tyr-Lys(DTPA)-Lys(thiosemicarbazonyl-glyoxyl-cysteinyl-)-NH2 (IMP-192).</em> Molecular Imaging and Contrast agent Database (MICAD) [database online]. National Library of Medicine, NCBI, Bethesda, MD, USA. Available from <a href="http://www.micad.nih.gov/" ref="pagearea=cite-ref&targetsite=external&targetcat=link&targettype=uri">www<wbr style="display:inline-block"></wbr>.micad.nih.gov</a>, 2004 -to current. [<a href="https://pubmed.ncbi.nlm.nih.gov/21834181" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 21834181</span></a>]</div></dd></dl></div><div id="bk_toc_contnr"></div></div></div>
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<div class="post-content"><div><div class="half_rhythm"><a href="/books/about/copyright/">Copyright Notice</a></div><div class="small"><span class="label">Bookshelf ID: NBK57131</span><span class="label">PMID: <a href="https://pubmed.ncbi.nlm.nih.gov/21834182" title="PubMed record of this page" ref="pagearea=meta&targetsite=entrez&targetcat=link&targettype=pubmed">21834182</a></span></div><div style="margin-top:2em" class="bk_noprnt"><a class="bk_cntns" href="/books/n/micad/">Contents</a><div class="pagination bk_noprnt"><a class="active page_link prev" href="/books/n/micad/EGFR-Fab125I/" title="Previous page in this title">< Prev</a><a class="active page_link next" href="/books/n/micad/Peptides125I/" title="Next page in this title">Next ></a></div></div></div></div>
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<div xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"></div><div class="portlet"><div class="portlet_head"><div class="portlet_title"><h3><span>Views</span></h3></div><a name="Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="PDF_download" id="Shutter"></a></div><div class="portlet_content"><ul xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="simple-list"><li><a href="/books/NBK57131/?report=reader">PubReader</a></li><li><a href="/books/NBK57131/?report=printable">Print View</a></li><li><a data-jig="ncbidialog" href="#_ncbi_dlg_citbx_NBK57131" data-jigconfig="width:400,modal:true">Cite this Page</a><div id="_ncbi_dlg_citbx_NBK57131" style="display:none" title="Cite this Page"><div class="bk_tt">Chopra A. 125I-Labeled anti-mucin 1 bispecific antibody bsPAM4. 2011 Jun 22 [Updated 2011 Jul 26]. In: Molecular Imaging and Contrast Agent Database (MICAD) [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2004-2013. <span class="bk_cite_avail"></span></div></div></li><li><a href="/books/NBK57131/pdf/Bookshelf_NBK57131.pdf">PDF version of this page</a> (140K)</li><li><a href="/books/n/micad/toc/bin/micad.csv">MICAD summary (CSV file)</a></li></ul></div></div><div class="portlet"><div class="portlet_head"><div class="portlet_title"><h3><span>In this page</span></h3></div><a name="Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="page-toc" id="Shutter"></a></div><div class="portlet_content"><ul xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="simple-list"><li><a href="#bsPAM4125I.Background" ref="log$=inpage&link_id=inpage">Background</a></li><li><a href="#bsPAM4125I.Synthesis" ref="log$=inpage&link_id=inpage">Synthesis</a></li><li><a href="#bsPAM4125I.In_Vitro_Studies_Testing_in_C" ref="log$=inpage&link_id=inpage"><i>In Vitro</i> Studies: Testing in Cells and Tissues</a></li><li><a href="#bsPAM4125I.Animal_Studies" ref="log$=inpage&link_id=inpage">Animal Studies</a></li><li><a href="#bsPAM4125I.Human_Studies" ref="log$=inpage&link_id=inpage">Human Studies</a></li><li><a href="#bsPAM4125I.Supplemental_Information" ref="log$=inpage&link_id=inpage">Supplemental Information</a></li><li><a href="#bsPAM4125I.NIH_Support" ref="log$=inpage&link_id=inpage">NIH Support</a></li><li><a href="#bsPAM4125I.References" ref="log$=inpage&link_id=inpage">References</a></li></ul></div></div><div class="portlet"><div class="portlet_head"><div class="portlet_title"><h3><span>Search MICAD</span></h3></div><a name="Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="source-application" id="Shutter"></a></div><div class="portlet_content"><form xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" name="frmSearch" method="get" action="/books/NBK5330/" id="frmSearch"><script type="text/javascript" src="/corehtml/pmc//js/bookshelf/micad.js">/**/</script><label class="offscreen_noflow" for="txtfield">Search term</label><input id="txtfield" type="text" name="f1_term" size="22" onKeyPress="KeyPress('micad',event,'/books/NBK5330/','')" /><button name="f1_search" type="submit">Go</button><button onclick="this.form.reset();" type="reset">Clear</button><p><b>Limit my Search:</b></p><div class="clearfix"><label for="detection">Method of detection:</label><div class="right"><select name="detection" id="detection" style="width:200px"><option value="" selected="selected">Any</option><option value="(MRI OR "Magnetic resonance imaging" OR MRS)">MRI</option><option value="Multimodal">Multimodal imaging</option><option value="Optical">Optical imaging</option><option value="PET">PET</option><option value="Photoacoustic">Photoacoustic imaging</option><option value="(SPECT OR planar)">SPECT</option><option value="Ultrasound">Ultrasound</option><option value="(x-ray OR ct)">X-ray, CT</option></select></div></div><div class="clearfix"><label for="signal">Source of signal/contrast:</label><div class="right"><select name="signal" id="signal" style="width:200px"><option value="" selected="selected">Any</option><optgroup label="MRI agents"><option value="(Copper OR Cu)">Copper</option><option value="(Europium OR Eu3+)">Europium</option><option value="(Fluorine OR 19F)">Fluorine</option><option value="(Gadolinium OR Gd3+)">Gadolinium</option><option value=""Hyperpolarized 13C"">Hyperpolarized 13C</option><option value=""Iron oxide"">Iron oxide</option><option value=""Nitroxide radicals"">Nitroxide radicals</option><option value="(Oxygen OR 17O)">Oxygen</option><option value="Thulium">Thulium</option></optgroup><optgroup label="Multimodal agents"><option value="((Gadolinium OR Gd3+) AND Optical)">Gadolinium and optical</option><option value="((Gadolinium OR Gd3+) AND (Gold OR Au))">Gadolinium and Gold</option><option value="("Iron oxide" AND (64Cu OR 124I OR 111In))">Iron oxide and
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