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<script type="text/javascript" src="/corehtml/pmc/jatsreader/ptpmc_3.22/js/jr.boots.min.js"> </script><title>Gd-DOTA-c(Cys-Arg-Gly-Asp-Cys) - Molecular Imaging and Contrast Agent Database (MICAD) - NCBI Bookshelf</title>
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<meta name="citation_inbook_title" content="Molecular Imaging and Contrast Agent Database (MICAD) [Internet]">
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<meta name="citation_title" content="Gd-DOTA-c(Cys-Arg-Gly-Asp-Cys)">
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<meta name="citation_date" content="2010/09/03">
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<meta name="citation_author" content="Kam Leung">
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<meta name="citation_pmid" content="20827824">
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<meta name="DC.Title" content="Gd-DOTA-c(Cys-Arg-Gly-Asp-Cys)">
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<meta name="DC.Contributor" content="Kam Leung">
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<meta name="description" content="Magnetic resonance imaging (MRI) maps information about tissues spatially and functionally. Protons (hydrogen nuclei) are widely used to create images because of their abundance in water molecules, which comprise >80% of most soft tissues. The contrast of proton MRI images depends mainly on the density of nuclear proton spins, the relaxation times of the nuclear magnetization (T1, longitudinal; T2, transverse), the magnetic environment of the tissues, and the blood flow to the tissues. However, insufficient contrast between normal and diseased tissues requires the use of contrast agents. Most contrast agents affect the T1 and T2 relaxation of the surrounding nuclei, mainly the protons of water. T2* is the spin–spin relaxation time composed of variations from molecular interactions and intrinsic magnetic heterogeneities of tissues in the magnetic field (1). Cross-linked iron oxide (CLIO) and other iron oxide formulations affect T2 primarily and lead to a decreased signal. On the other hand, paramagnetic T1 agents, such as gadolinium (Gd3+) and manganese (Mn2+), accelerate T1 relaxation and lead to increased contrast images.">
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<meta name="og:description" content="Magnetic resonance imaging (MRI) maps information about tissues spatially and functionally. Protons (hydrogen nuclei) are widely used to create images because of their abundance in water molecules, which comprise >80% of most soft tissues. The contrast of proton MRI images depends mainly on the density of nuclear proton spins, the relaxation times of the nuclear magnetization (T1, longitudinal; T2, transverse), the magnetic environment of the tissues, and the blood flow to the tissues. However, insufficient contrast between normal and diseased tissues requires the use of contrast agents. Most contrast agents affect the T1 and T2 relaxation of the surrounding nuclei, mainly the protons of water. T2* is the spin–spin relaxation time composed of variations from molecular interactions and intrinsic magnetic heterogeneities of tissues in the magnetic field (1). Cross-linked iron oxide (CLIO) and other iron oxide formulations affect T2 primarily and lead to a decreased signal. On the other hand, paramagnetic T1 agents, such as gadolinium (Gd3+) and manganese (Mn2+), accelerate T1 relaxation and lead to increased contrast images.">
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yet</button><a id="jr-fip-next" class="wsprkl btn" title="Jump to next match">▶</a></nav></nav></div><div id="jr-epub-interstitial" class="hidden"></div><div id="jr-content"><article data-type="main"><div class="main-content lit-style" itemscope="itemscope" itemtype="http://schema.org/CreativeWork"><div class="meta-content fm-sec"><div class="fm-sec"><h1 id="_NBK45635_"><span class="title" itemprop="name">Gd-DOTA-c(Cys-Arg-Gly-Asp-Cys)</span></h1><div itemprop="alternativeHeadline" class="subtitle whole_rhythm">P975</div><p class="contribs">Leung K.</p><p class="fm-aai"><a href="#_NBK45635_pubdet_">Publication Details</a></p></div></div><div class="jig-ncbiinpagenav body-content whole_rhythm" data-jigconfig="allHeadingLevels: ['h2'],smoothScroll: false" itemprop="text"><div class="iconblock whole_rhythm clearfix ten_col table-wrap" id="figP975Tncchemicalnamegddotaccysargglya"><a href="/books/NBK45635/table/P975.T.nc_chemical_namegddotaccysargglya/?report=objectonly" target="object" title="Table" class="img_link icnblk_img" rid-ob="figobP975Tncchemicalnamegddotaccysargglya"><img class="small-thumb" src="/corehtml/pmc/css/bookshelf/2.26/img/table-icon.gif" alt="Table Icon" /></a><div class="icnblk_cntnt"><h4 id="P975.T.nc_chemical_namegddotaccysargglya"><a href="/books/NBK45635/table/P975.T.nc_chemical_namegddotaccysargglya/?report=objectonly" target="object" rid-ob="figobP975Tncchemicalnamegddotaccysargglya">Table</a></h4><p class="float-caption no_bottom_margin">
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<i>In vitro</i>
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Rodents
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</p></div></div><div id="P975.Background"><h2 id="_P975_Background_">Background</h2><p>[<a href="/sites/entrez?Db=pubmed&Cmd=DetailsSearch&Term=P975" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">PubMed</a>]</p><p>Magnetic resonance imaging (MRI) maps information about tissues spatially and functionally. Protons (hydrogen nuclei) are widely used to create images because of their abundance in water molecules, which comprise >80% of most soft tissues. The contrast of proton MRI images depends mainly on the density of nuclear proton spins, the relaxation times of the nuclear magnetization (T1, longitudinal; T2, transverse), the magnetic environment of the tissues, and the blood flow to the tissues. However, insufficient contrast between normal and diseased tissues requires the use of contrast agents. Most contrast agents affect the T1 and T2 relaxation of the surrounding nuclei, mainly the protons of water. T2* is the spin–spin relaxation time composed of variations from molecular interactions and intrinsic magnetic heterogeneities of tissues in the magnetic field (<a class="bibr" href="#P975.REF.1" rid="P975.REF.1">1</a>). Cross-linked iron oxide (CLIO) and other iron oxide formulations affect T2 primarily and lead to a decreased signal. On the other hand, paramagnetic T1 agents, such as gadolinium (Gd<sup>3+</sup>) and manganese (Mn<sup>2+</sup>), accelerate T1 relaxation and lead to increased contrast images.</p><p>Thrombosis plays a major role in many cardiovascular diseases, such as myocardial infarction, pulmonary embolism (PE), deep venous thrombosis (DVT), atherothrombosis, or cerebral venous thrombosis (<a class="bibr" href="#P975.REF.2" rid="P975.REF.2 P975.REF.3">2, 3</a>). DVT is a significant cause of PE, which is a potentially life-threatening clinical problem. Thrombosis occurs when platelets deposit in regions of low flow in the deep venous system, followed by an activation process of thrombin, which then converts fibrinogen into fibrin. Platelets become activated and bind to fibrinogen, resulting in platelet aggregation <i>via</i> the platelet integrin GPIIb/IIIa (α<sub>IIb</sub>β<sub>3</sub>, CD61/CD41). The thrombus may become organized or detached from the vessel wall.</p><p>A single-chain antibody (anti-LIBS 145) has been developed to recognize ligand-induced binding sites (LIBS) of GPIIb/IIIa that become exposed only upon binding to fibrinogen (<a class="bibr" href="#P975.REF.4" rid="P975.REF.4">4</a>). Anti-LIBS 145 single-chain antibody does not bind to circulating platelets. Anti-LIBS 145 single-chain antibody was conjugated to microparticles of iron oxide (MPIOs) to form LIBS-MPIOs for T2-weighted MRI imaging of platelet-containing thrombi (<a class="bibr" href="#P975.REF.5" rid="P975.REF.5 P975.REF.6 P975.REF.7 P975.REF.8">5-8</a>). The cyclic peptide P977 (cyclo(Cys-Arg-Gly-Asp-Cys)) was found to bind to platelet glycoprotein GPIIb/IIIa receptor with good affinity (<a class="bibr" href="#P975.REF.9" rid="P975.REF.9">9</a>). P975 is composed of P977-conjugated gadolinium-tetraazacyclododecane-<i>N</i>,<i>N’</i>,<i>N’’</i>,<i>N’’’</i>-tetraacetic acid (Gd-DOTA) (<a class="bibr" href="#P975.REF.10" rid="P975.REF.10">10</a>). P975 is being developed as a non-invasive T1 MRI agent for GPIIb/IIIa expression in thrombi.</p><div id="P975.Related_Resource_Links"><h3>Related Resource Links:</h3><ul><li class="half_rhythm"><div>
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<a href="/sites/entrez?db=Books&cmd=Search&term=GPIIb/IIIa%20+AND+micad%5bbook%5d&doptcmdl=TOCView&log%24=booksrch&bname=micad" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">Chapters in MICAD</a>
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</div></li><li class="half_rhythm"><div>Gene information in NCBI (<a href="/gene/3690" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">GPIIIa/CD61</a>, <a href="/gene/3674" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">GPIIb/CD41</a>)</div></li><li class="half_rhythm"><div><a href="/omim/?term=VCAM-1" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">Articles in OMIM</a> (<a href="/entrez/dispomim.cgi?id=173470" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">GPIIIa/CD61</a>, <a href="/entrez/dispomim.cgi?id=607759" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">GPIIb/CD41</a>)</div></li><li class="half_rhythm"><div>Clinical trials (<a href="http://www.clinicaltrials.gov/ct2/results?term=integrin" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">Integrin</a>)</div></li><li class="half_rhythm"><div>
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<a href="http://google2.fda.gov/search?q=integrin&client=FDAgov&site=FDAgov&lr=&proxystylesheet=FDAgov&output=xml_no_dtd&getfields=*&x=17&y=16" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">Drug information in FDA</a>
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</div></li></ul></div></div><div id="P975.Synthesis"><h2 id="_P975_Synthesis_">Synthesis</h2><p>[<a href="/sites/entrez?Db=pubmed&Cmd=DetailsSearch&Term=P975+and+synthesis" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">PubMed</a>]</p><p>Gd-DOTA was conjugated to P977 <i>via</i> a small linker at a 1:1 ratio (<a class="bibr" href="#P975.REF.10" rid="P975.REF.10">10</a>). P975 exhibited an <i>r</i><sub>1</sub> relaxivity value of 9 mM<sup>-1</sup>s<sup>-1</sup> at 40°C and 60 MHz.</p></div><div id="P975.In_Vitro_Studies_Testing_in_Cells_a"><h2 id="_P975_In_Vitro_Studies_Testing_in_Cells_a_"><i>In Vitro</i> Studies: Testing in Cells and Tissues</h2><p>[<a href="/sites/entrez?Db=pubmed&Cmd=DetailsSearch&Term=P975+and+in+vitro" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">PubMed</a>]</p><p><i>In vitro</i> competition binding to activated platelets was performed using FITC-fibrinogen with P975 and P977 (<a class="bibr" href="#P975.REF.10" rid="P975.REF.10">10</a>). The 50% inhibition concentrations for P975 and P977 were 2.1 ± 0.3 µM and 1.6 ± 0.2 µM, respectively.</p></div><div id="P975.Animal_Studies"><h2 id="_P975_Animal_Studies_">Animal Studies</h2><div id="P975.Rodents"><h3>Rodents</h3><p>[<a href="/sites/entrez?Db=pubmed&Cmd=DetailsSearch&Term=P975+and+rodentia" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">PubMed</a>]</p><p>Klink et al. (<a class="bibr" href="#P975.REF.10" rid="P975.REF.10">10</a>) performed <i>in vivo</i> T1-weighted MRI (9.4 T) of arachidonic acid–treated right carotid arteries in mice (<i>n</i> = 5/group) to induce thrombosis. P975 or Gd-DOTA (0.1 mmol/kg) was injected intravenously after thrombus formation. MRI scans were performed every 15 min up to 120 min after injection. An initial signal enhancement was observed with both P975 and Gd-DOTA in the lumen of the thrombosed carotid artery at 30 min after injection. However, there was a rapid washout with Gd-DOTA. The enhancement with P975 persisted over time and was still present at 120 min. There were three-fold, six-fold, and seven-fold increases in change in contrast/noise ratio for the P975 group compared with the Gd-DOTA group, the sham surgery group, and the control group (<i>P</i> < 0.01), respectively, at 120 min after injection. Injection of eptifibatide (GPIIb/IIIa antagonist) a few minutes before injection of P975 reduced the signal enhancement in the P975 group to the level of the Gd-DOTA group at 120 min after injection.</p></div><div id="P975.Other_NonPrimate_Mammals"><h3>Other Non-Primate Mammals</h3><p>[<a href="/sites/entrez?Db=pubmed&Cmd=DetailsSearch&Term=P975+and+(dog+or+sheep+or+pig+or+rabbit)" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">PubMed</a>]</p><p>No publication is currently available.</p></div><div id="P975.NonHuman_Primates"><h3>Non-Human Primates</h3><p>[<a href="/sites/entrez?Db=pubmed&Cmd=DetailsSearch&Term=P975+and+(primate+not+human)" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">PubMed</a>]</p><p>No publication is currently available.</p></div></div><div id="P975.Human_Studies"><h2 id="_P975_Human_Studies_">Human Studies</h2><p>[<a href="/sites/entrez?Db=pubmed&Cmd=DetailsSearch&Term=P975+and+human" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">PubMed</a>]</p><p>No publication is currently available.</p></div><div id="P975.NIH_Support"><h2 id="_P975_NIH_Support_">NIH Support</h2><p>R01 HL71021, R01 HL78667, R01 EB009638</p></div><div id="P975.References"><h2 id="_P975_References_">References</h2><dl class="temp-labeled-list"><dl class="bkr_refwrap"><dt>1.</dt><dd><div class="bk_ref" id="P975.REF.1">Wang Y.X., Hussain S.M., Krestin G.P.
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<em>Superparamagnetic iron oxide contrast agents: physicochemical characteristics and applications in MR imaging.</em>
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<span><span class="ref-journal">Eur Radiol. </span>2001;<span class="ref-vol">11</span>(11):2319–31.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/11702180" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 11702180</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>2.</dt><dd><div class="bk_ref" id="P975.REF.2">Corti R., Fuster V.
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<em>New understanding, diagnosis, and prognosis of atherothrombosis and the role of imaging.</em>
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<span><span class="ref-journal">Am J Cardiol. </span>2003;<span class="ref-vol">91</span>(3A):17A–26A.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/12645640" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 12645640</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>3.</dt><dd><div class="bk_ref" id="P975.REF.3">Taillefer R.
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<em>Radiolabeled peptides in the detection of deep venous thrombosis.</em>
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<span><span class="ref-journal">Semin Nucl Med. </span>2001;<span class="ref-vol">31</span>(2):102–23.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/11330782" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 11330782</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>4.</dt><dd><div class="bk_ref" id="P975.REF.4">Schwarz M., Katagiri Y., Kotani M., Bassler N., Loeffler C., Bode C., Peter K.
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<em>Reversibility versus persistence of GPIIb/IIIa blocker-induced conformational change of GPIIb/IIIa (alphaIIbbeta3, CD41/CD61).</em>
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<span><span class="ref-journal">J Pharmacol Exp Ther. </span>2004;<span class="ref-vol">308</span>(3):1002–11.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/14617694" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 14617694</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>5.</dt><dd><div class="bk_ref" id="P975.REF.5">von zur Muhlen C., Peter K., Ali Z.A., Schneider J.E., McAteer M.A., Neubauer S., Channon K.M., Bode C., Choudhury R.P.
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<em>Visualization of activated platelets by targeted magnetic resonance imaging utilizing conformation-specific antibodies against glycoprotein IIb/IIIa.</em>
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<span><span class="ref-journal">J Vasc Res. </span>2009;<span class="ref-vol">46</span>(1):6–14.</span> [<a href="/pmc/articles/PMC2914450/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC2914450</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/18515970" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 18515970</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>6.</dt><dd><div class="bk_ref" id="P975.REF.6">von Zur Muhlen C., Sibson N.R., Peter K., Campbell S.J., Wilainam P., Grau G.E., Bode C., Choudhury R.P., Anthony D.C.
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<em>A contrast agent recognizing activated platelets reveals murine cerebral malaria pathology undetectable by conventional MRI.</em>
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<span><span class="ref-journal">J Clin Invest. </span>2008;<span class="ref-vol">118</span>(3):1198–207.</span> [<a href="/pmc/articles/PMC2242620/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC2242620</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/18274670" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 18274670</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>7.</dt><dd><div class="bk_ref" id="P975.REF.7">von Zur Muhlen C., von Elverfeldt D., Choudhury R.P., Ender J., Ahrens I., Schwarz M., Hennig J., Bode C., Peter K.
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<em>Functionalized magnetic resonance contrast agent selectively binds to glycoprotein IIb/IIIa on activated human platelets under flow conditions and is detectable at clinically relevant field strengths.</em>
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<span><span class="ref-journal">Mol Imaging. </span>2008;<span class="ref-vol">7</span>(2):59–67.</span> [<a href="/pmc/articles/PMC2912508/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC2912508</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/18706288" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 18706288</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>8.</dt><dd><div class="bk_ref" id="P975.REF.8">von zur Muhlen C., von Elverfeldt D., Moeller J.A., Choudhury R.P., Paul D., Hagemeyer C.E., Olschewski M., Becker A., Neudorfer I., Bassler N., Schwarz M., Bode C., Peter K.
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<em>Magnetic resonance imaging contrast agent targeted toward activated platelets allows in vivo detection of thrombosis and monitoring of thrombolysis.</em>
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<span><span class="ref-journal">Circulation. </span>2008;<span class="ref-vol">118</span>(3):258–67.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/18574047" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 18574047</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>9.</dt><dd><div class="bk_ref" id="P975.REF.9">Yamada T., Kidera A.
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<em>Tailoring echistatin to possess higher affinity for integrin alpha(IIb)beta(3).</em>
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<span><span class="ref-journal">FEBS Lett. </span>1996;<span class="ref-vol">387</span>(1):11–15.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/8654558" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 8654558</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>10.</dt><dd><div class="bk_ref" id="P975.REF.10">Klink A., Lancelot E., Ballet S., Vucic E., Fabre J.E., Gonzalez W., Medina C., Corot C., Mulder W.J., Mallat Z., Fayad Z.A.
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<em>Magnetic resonance molecular imaging of thrombosis in an arachidonic acid mouse model using an activated platelet targeted probe.</em>
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<span><span class="ref-journal">Arterioscler Thromb Vasc Biol. </span>2010;<span class="ref-vol">30</span>(3):403–10.</span> [<a href="/pmc/articles/PMC2864133/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC2864133</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/20139362" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 20139362</span></a>]</div></dd></dl></dl></div><div id="bk_toc_contnr"></div></div></div><div class="fm-sec"><h2 id="_NBK45635_pubdet_">Publication Details</h2><h3>Author Information and Affiliations</h3><div class="contrib half_rhythm"><span itemprop="author">Kam Leung</span>, PhD<div class="affiliation small">National Center for Biotechnology Information, NLM, NIH, Bethesda, MD<div><span class="email-label">Email: </span><a href="mailto:dev@null" data-email="vog.hin.mln.ibcn@DACIM" class="oemail">vog.hin.mln.ibcn@DACIM</a></div></div><div class="small">Corresponding author.</div></div><h3>Publication History</h3><p class="small">Created: <span itemprop="datePublished">June 27, 2010</span>; Last Update: <span itemprop="dateModified">September 3, 2010</span>.</p><h3>Copyright</h3><div><div class="half_rhythm"><a href="/books/about/copyright/">Copyright Notice</a></div></div><h3>Publisher</h3><p><a href="http://www.ncbi.nlm.nih.gov/" ref="pagearea=page-banner&targetsite=external&targetcat=link&targettype=publisher">National Center for Biotechnology Information (US)</a>, Bethesda (MD)</p><h3>NLM Citation</h3><p>Leung K. Gd-DOTA-c(Cys-Arg-Gly-Asp-Cys) 2010 Jun 27 [Updated 2010 Sep 3]. In: Molecular Imaging and Contrast Agent Database (MICAD) [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2004-2013. <span class="bk_cite_avail"></span></p></div><div class="small-screen-prev"><a href="/books/n/micad/GdAB42/?report=reader"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 100 100" preserveAspectRatio="none"><path d="M75,30 c-80,60 -80,0 0,60 c-30,-60 -30,0 0,-60"></path><text x="20" y="28" textLength="60" style="font-size:25px">Prev</text></svg></a></div><div class="small-screen-next"><a href="/books/n/micad/GdPCA2/?report=reader"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 100 100" preserveAspectRatio="none"><path d="M25,30c80,60 80,0 0,60 c30,-60 30,0 0,-60"></path><text x="20" y="28" textLength="60" style="font-size:25px">Next</text></svg></a></div></article><article data-type="table-wrap" id="figobP975Tncchemicalnamegddotaccysargglya"><div id="P975.T.nc_chemical_namegddotaccysargglya" class="table"><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK45635/table/P975.T.nc_chemical_namegddotaccysargglya/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__P975.T.nc_chemical_namegddotaccysargglya_lrgtbl__"><table><tbody><tr><td rowspan="1" colspan="1" style="text-align:right;vertical-align:top;">
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<b>Chemical name:</b>
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</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Gd-DOTA-c(Cys-Arg-Gly-Asp-Cys)</td><td rowspan="9" colspan="1" style="text-align:center;vertical-align:middle;"></td></tr><tr><td rowspan="1" colspan="1" style="text-align:right;vertical-align:top;">
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<b>Abbreviated name:</b>
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</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">P975</td></tr><tr><td rowspan="1" colspan="1" style="text-align:right;vertical-align:top;">
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<b>Synonym:</b>
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</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td></tr><tr><td rowspan="1" colspan="1" style="text-align:right;vertical-align:top;">
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<b>Agent category:</b>
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</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Peptide</td></tr><tr><td rowspan="1" colspan="1" style="text-align:right;vertical-align:top;">
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<b>Target:</b>
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</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Platelet glycoprotein GPIIb/IIIa receptor (CD61/CD41)</td></tr><tr><td rowspan="1" colspan="1" style="text-align:right;vertical-align:top;">
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<b>Target category:</b>
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</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Receptor</td></tr><tr><td rowspan="1" colspan="1" style="text-align:right;vertical-align:top;">
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<b>Method of detection:</b>
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</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Magnetic resonance imaging (MRI)</td></tr><tr><td rowspan="1" colspan="1" style="text-align:right;vertical-align:top;">
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<b>Source of signal:</b>
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</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Gd</td></tr><tr><td rowspan="1" colspan="1" style="text-align:right;vertical-align:top;">
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<b>Activation:</b>
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</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">No</td></tr><tr><td rowspan="1" colspan="1" style="text-align:right;vertical-align:top;">
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<b>Studies:</b>
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</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<ul class="simple-list"><li class="half_rhythm"><div>
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<img alt="Checkbox" src="/corehtml/pmc/css/bookshelf/2.26/img/studies.checkbox.png" />
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<i>In vitro</i>
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</div></li><li class="half_rhythm"><div>
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<img alt="Checkbox" src="/corehtml/pmc/css/bookshelf/2.26/img/studies.checkbox.png" /> Rodents
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</div></li></ul>
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</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Structure is not available in PubChem.</td></tr></tbody></table></div></div></article></div><div id="jr-scripts"><script src="/corehtml/pmc/jatsreader/ptpmc_3.22/js/libs.min.js"> </script><script src="/corehtml/pmc/jatsreader/ptpmc_3.22/js/jr.min.js"> </script></div></div>
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