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<script type="text/javascript" src="/corehtml/pmc/jatsreader/ptpmc_3.22/js/jr.boots.min.js"> </script><title>99mTc-Labeled O-[3-(1,4,8,11-tetraazabicyclohexadecane)-propyl]-α-methyl tyrosine - Molecular Imaging and Contrast Agent Database (MICAD) - NCBI Bookshelf</title>
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<meta name="citation_inbook_title" content="Molecular Imaging and Contrast Agent Database (MICAD) [Internet]">
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<meta name="citation_title" content="99mTc-Labeled O-[3-(1,4,8,11-tetraazabicyclohexadecane)-propyl]-α-methyl tyrosine">
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<meta name="citation_date" content="2011/12/01">
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<meta name="citation_author" content="Arvind Chopra">
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<meta name="DC.Title" content="99mTc-Labeled O-[3-(1,4,8,11-tetraazabicyclohexadecane)-propyl]-α-methyl tyrosine">
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<meta name="DC.Contributor" content="Arvind Chopra">
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<meta name="description" content="High energy consumption and rapid proliferation are the distinct characteristics of all cells with a malignant phenotype. To maintain a high pace of protein and DNA synthesis, such cells have an increased demand for various nutrients, glucose, and amino acids (aa). Therefore, radiotracers such as 18F-labeled fluorodeoxyglucose, which is taken up by the cell through the glucose transporter, are often used with positron emission tomography to detect cancerous tumors. This agent, however, is not suitable to distinguish between malignant tissue, inflammation, and tissues that normally have high glucose consumption, such as the brain (1). As an alternative, radiolabeled aa and their derivatives, such as those of phenylalanine and tyrosine, have been used by investigators to detect neoplastic tumors because these lesions show increased utilization of aa for the synthesis of proteins and other cellular components (2, 3). To accommodate the increased demand for aa, the malignant cells overexpress the aa transporters (phenylalanine and tyrosine use the L-type transporter), and this phenomenon promotes the rapid uptake and accumulation of the radiolabeled aa in the tumors. Therefore, noninvasive imaging with a radiolabeled aa can be used to detect cancerous lesions within a short time after administration of the tracer aa. Among the various radiolabeled aa tracers, [18F]- α-methyl-tyrosine ([18F]-AMT) is often used in the clinic, but the low yield of the final labeled product and the requirement of an on-site cyclotron to produce 18F (half-life, ~110 min) prohibit the use of this labeled compound in most oncology centers (1).">
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<meta name="og:description" content="High energy consumption and rapid proliferation are the distinct characteristics of all cells with a malignant phenotype. To maintain a high pace of protein and DNA synthesis, such cells have an increased demand for various nutrients, glucose, and amino acids (aa). Therefore, radiotracers such as 18F-labeled fluorodeoxyglucose, which is taken up by the cell through the glucose transporter, are often used with positron emission tomography to detect cancerous tumors. This agent, however, is not suitable to distinguish between malignant tissue, inflammation, and tissues that normally have high glucose consumption, such as the brain (1). As an alternative, radiolabeled aa and their derivatives, such as those of phenylalanine and tyrosine, have been used by investigators to detect neoplastic tumors because these lesions show increased utilization of aa for the synthesis of proteins and other cellular components (2, 3). To accommodate the increased demand for aa, the malignant cells overexpress the aa transporters (phenylalanine and tyrosine use the L-type transporter), and this phenomenon promotes the rapid uptake and accumulation of the radiolabeled aa in the tumors. Therefore, noninvasive imaging with a radiolabeled aa can be used to detect cancerous lesions within a short time after administration of the tracer aa. Among the various radiolabeled aa tracers, [18F]- α-methyl-tyrosine ([18F]-AMT) is often used in the clinic, but the low yield of the final labeled product and the requirement of an on-site cyclotron to produce 18F (half-life, ~110 min) prohibit the use of this labeled compound in most oncology centers (1).">
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id="jr-fip-info-p"><a id="jr-fip-prev" class="wsprkl btn" title="Jump to previuos match">◀</a><button id="jr-fip-matches">no matches yet</button><a id="jr-fip-next" class="wsprkl btn" title="Jump to next match">▶</a></nav></nav></div><div id="jr-epub-interstitial" class="hidden"></div><div id="jr-content"><article data-type="main"><div class="main-content lit-style" itemscope="itemscope" itemtype="http://schema.org/CreativeWork"><div class="meta-content fm-sec"><div class="fm-sec"><h1 id="_NBK82378_"><span class="title" itemprop="name"><sup>99m</sup>Tc-Labeled O-[3-(1,4,8,11-tetraazabicyclohexadecane)-propyl]-α-methyl tyrosine</span></h1><div itemprop="alternativeHeadline" class="subtitle whole_rhythm"> [<sup>99m</sup>Tc]-N4-AMT</div><p class="contribs">Chopra A.</p><p class="fm-aai"><a href="#_NBK82378_pubdet_">Publication Details</a></p></div></div><div class="jig-ncbiinpagenav body-content whole_rhythm" data-jigconfig="allHeadingLevels: ['h2'],smoothScroll: false" itemprop="text"><div class="iconblock whole_rhythm clearfix ten_col table-wrap" id="figN4AMT99mTcTncchemicalname99mtclabele"><a href="/books/NBK82378/table/N4AMT99mTc.T.nc_chemical_name99mtclabele/?report=objectonly" target="object" title="Table" class="img_link icnblk_img" rid-ob="figobN4AMT99mTcTncchemicalname99mtclabele"><img class="small-thumb" src="/corehtml/pmc/css/bookshelf/2.26/img/table-icon.gif" alt="Table Icon" /></a><div class="icnblk_cntnt"><h4 id="N4AMT99mTc.T.nc_chemical_name99mtclabele"><a href="/books/NBK82378/table/N4AMT99mTc.T.nc_chemical_name99mtclabele/?report=objectonly" target="object" rid-ob="figobN4AMT99mTcTncchemicalname99mtclabele">Table</a></h4><p class="float-caption no_bottom_margin">
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<i>In vitro</i>
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Rodents
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</p></div></div><div id="N4AMT99mTc.Background"><h2 id="_N4AMT99mTc_Background_">Background</h2><p>[<a href="/pubmed?term=amino%20acid%20and%20imaging%20and%20amino%20acid%20transporters" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">PubMed</a>]</p><p>High energy consumption and rapid proliferation are the distinct characteristics of all cells with a malignant phenotype. To maintain a high pace of protein and DNA synthesis, such cells have an increased demand for various nutrients, glucose, and amino acids (aa). Therefore, radiotracers such as <sup>18</sup>F-labeled fluorodeoxyglucose, which is taken up by the cell through the glucose transporter, are often used with positron emission tomography to detect cancerous tumors. This agent, however, is not suitable to distinguish between malignant tissue, inflammation, and tissues that normally have high glucose consumption, such as the brain (<a class="bibr" href="#N4AMT99mTc.REF.1" rid="N4AMT99mTc.REF.1">1</a>). As an alternative, radiolabeled aa and their derivatives, such as those of phenylalanine and tyrosine, have been used by investigators to detect neoplastic tumors because these lesions show increased utilization of aa for the synthesis of proteins and other cellular components (<a class="bibr" href="#N4AMT99mTc.REF.2" rid="N4AMT99mTc.REF.2 N4AMT99mTc.REF.3">2, 3</a>). To accommodate the increased demand for aa, the malignant cells overexpress the aa transporters (phenylalanine and tyrosine use the L-type transporter), and this phenomenon promotes the rapid uptake and accumulation of the radiolabeled aa in the tumors. Therefore, noninvasive imaging with a radiolabeled aa can be used to detect cancerous lesions within a short time after administration of the tracer aa. Among the various radiolabeled aa tracers, [<sup>18</sup>F]- α-methyl-tyrosine ([<sup>18</sup>F]-AMT) is often used in the clinic, but the low yield of the final labeled product and the requirement of an on-site cyclotron to produce <sup>18</sup>F (half-life, ~110 min) prohibit the use of this labeled compound in most oncology centers (<a class="bibr" href="#N4AMT99mTc.REF.1" rid="N4AMT99mTc.REF.1">1</a>).</p><p>In an effort to develop an alternative to [<sup>18</sup>F]-AMT, Kong et al. conjugated O-[3-(1,4,8,11-tetraazabicyclohexadecane)-propyl] (N4; a metal chelator) to α-methyl tyrosine (AMT) and labeled it with <sup>99m</sup>Tc ([<sup>99m</sup>Tc]-N4-AMT) (<a class="bibr" href="#N4AMT99mTc.REF.1" rid="N4AMT99mTc.REF.1">1</a>). The main advantage of using <sup>99m</sup>Tc instead of <sup>18</sup>F is that the former nuclide has a longer half-life (~ 6 h) and can be produced in-house with a generator instead of a cyclotron. In addition, the N4 chelator in N4-AMT can also bind <sup>188</sup>Re, a therapeutic nuclide that can be used to treat cancers. The biodistribution of [<sup>99m</sup>Tc]-N4-AMT has been investigated in normal rats, and in a separate study the labeled compound was evaluated with gamma planar imaging for the visualization of rat <a href="http://www.atcc.org/ATCCAdvancedCatalogSearch/ProductDetails/tabid/452/Default.aspx?ATCCNum=CRL-1666&Template=cellBiology" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">13762 cell</a> tumors in the animals (<a class="bibr" href="#N4AMT99mTc.REF.1" rid="N4AMT99mTc.REF.1">1</a>).</p><div id="N4AMT99mTc.Related_Resource_Links"><h3>Related Resource Links</h3><p>Related chapters in <a href="/books/?term=Amino+acid+transporter+AND+micad%5Bbook%5D&view=chapter&p%24a=&p%24l=PBooksLayout&p%24st=books" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">MICAD</a></p><p>Information on L-type amino acid transporters in <a href="/pubmed?term=L-type%20amino%20acid%20transporter&cmd=DetailsSearch" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">PubMed</a></p><p>Inhibition of amino acid transport <a href="/pubmed?term=Inhibition%20of%20amino%20acid%20transport&cmd=DetailsSearch" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">PubMed</a></p><p><a href="/nuccore?term=L-type%20amino%20acid%20transporter" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">Nucleotide and protein</a> sequences of mammalian amino acid transporters</p><p>L-type amino acid transporter in <a href="http://omim.org/entry/603733" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">Online Mandelian Inheritance in Man Database (OMIM)</a></p></div></div><div id="N4AMT99mTc.Synthesis"><h2 id="_N4AMT99mTc_Synthesis_">Synthesis</h2><p>[<a href="/pubmed?term=99mTc-N4-AMT%20synthesis&cmd=DetailsSearch" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">PubMed</a>]</p><p>The synthesis of N4-AMT and its labeling with <sup>99m</sup>Tc have been described by Kong et al. (<a class="bibr" href="#N4AMT99mTc.REF.1" rid="N4AMT99mTc.REF.1">1</a>). The radiochemical purity (RCP) of the labeled compound was reported to be >96% as assessed using a C18 column with reversed-phase high-performance liquid chromatography (retention time, 6.899 min). The radiochemical yield (RCY), specific activity, and stability of [<sup>99m</sup>Tc]-N4-AMT were not reported.</p><p>In some studies, [<sup>99m</sup>Tc]-N4 was used as a control, but its RCY, RCP, and specific activity were not reported (<a class="bibr" href="#N4AMT99mTc.REF.1" rid="N4AMT99mTc.REF.1">1</a>).</p></div><div id="N4AMT99mTc.In_Vitro_Studies_Testing_in_C"><h2 id="_N4AMT99mTc_In_Vitro_Studies_Testing_in_C_"><i>In Vitro</i> Studies: Testing in Cells and Tissues</h2><p>[<a href="/pubmed?term=99mTc-N4-AMT%20in%20vitro%20studies&cmd=DetailsSearch" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">PubMed</a>]</p><p>The uptake of [<sup>99m</sup>Tc]-N4-AMT and [<sup>99m</sup>Tc]-N4 was investigated in rat 13762 cells (<a class="bibr" href="#N4AMT99mTc.REF.1" rid="N4AMT99mTc.REF.1">1</a>). The cells were observed to gradually accumulate radioactivity for up to 240 min only with [<sup>99m</sup>Tc]-N4-AMT. No such uptake by the cells was observed with [<sup>99m</sup>Tc]-N4. This indicated that the labeled amino acid derivative was probably taken up by the cells through the aa transport system; however, this was not confirmed with the use of appropriate aa transport inhibitors. </p></div><div id="N4AMT99mTc.Animal_Studies"><h2 id="_N4AMT99mTc_Animal_Studies_">Animal Studies</h2><div id="N4AMT99mTc.Rodents"><h3>Rodents</h3><p>[<a href="/pubmed?term=99mTc-N4-AMT%20rodentia&cmd=DetailsSearch" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">PubMed</a>]</p><p>The biodistribution of [<sup>99m</sup>Tc]-N4-AMT was investigated in normal Fischer 344 rats (n = 3 animals/time point) as described by Kong et al. (<a class="bibr" href="#N4AMT99mTc.REF.1" rid="N4AMT99mTc.REF.1">1</a>). Each rat was injected intravenously with either 0.92 ± 0.01 MBq (25 ± 0.5 μCi) [<sup>99m</sup>Tc]-N4-AMT or [<sup>99m</sup>Tc]-N4, and the animals were euthanized at 0.5, 2, and 4 h postinjection (p.i.) to determine the amount of radioactivity accumulated in the various organs. Data obtained from this study were presented as percent of injected dose per gram tissue (% ID/g). With [<sup>99m</sup>Tc]-N4-AMT, maximum uptake of radioactivity was observed in the kidneys (5.77 ± 0.35% ID/g), followed by the liver (1.40 ± 0.07% ID/g) and thyroid (0.57 ± 0.04% ID/g) at 0.5 h p.i., and the label in these organs decreased to 4.74 ± 0.33% ID/g, 0.60 ± 0.02% ID/g, and 0.24 ± 0.1% ID/g, respectively, at 4 h p.i. All other organs showed an uptake between 0.03 ± 0.00% ID/g (brain) and 0.50 ± 0.02% ID/g (stomach) at 0.5 h p.i., which decreased to between 0.01 ± 0.00% ID/g (brain) and 0.43 ± 0.02% ID/g (stomach) at 4 h p.i. Data for [<sup>99m</sup>Tc]-N4 and blocking studies with [<sup>99m</sup>Tc]-N4-AMT were not reported.</p><p>In another study, Fisher 344 rats (n = 3 animals/tracer) bearing rat 13762 cell tumors on the right posterior leg were injected with either 11.11 MBq/rat (300 μCi/rat) [<sup>99m</sup>Tc]-N4-AMT (0.3 mg/rat) or [<sup>99m</sup>Tc]-N4 (0.15 mg/rat) as described above (<a class="bibr" href="#N4AMT99mTc.REF.1" rid="N4AMT99mTc.REF.1">1</a>). Planar scintigraphic images of the animals were then acquired at 0.5, 1, and 2 h p.i. Radioactivity counts per pixel were calculated from computer-outlined regions of interest from the images of the tumors, and the normal surrounding muscle and the tumor/muscle (T/M) ratios were calculated at the different time points. The tumors were clearly visible at the various time points only in rats injected with [<sup>99m</sup>Tc]-N4-AMT. The T/M ratios for [<sup>99m</sup>Tc]-N4-AMT and [<sup>99m</sup>Tc]-N4 were reported to be 2.3 and 1.28, respectively, at 0.5 h p.i., and these ratios for the two tracers increased to 4 and 2.3, respectively, at 2 h p.i.</p><p>From these studies, the investigators concluded that [<sup>99m</sup>Tc]-N4-AMT can be used for the imaging of tumors in rodents (<a class="bibr" href="#N4AMT99mTc.REF.1" rid="N4AMT99mTc.REF.1">1</a>).</p></div><div id="N4AMT99mTc.Other_NonPrimate_Mammals"><h3>Other Non-Primate Mammals</h3><p>[<a href="/pubmed?term=99mTc-N4-AMT%20Non-Primate%20Mammals&cmd=DetailsSearch" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">PubMed</a>]</p><p>No publication is currently available.</p></div><div id="N4AMT99mTc.NonHuman_Primates"><h3>Non-Human Primates</h3><p>[<a href="/pubmed?term=99mTc-N4-AMT%20Non-Human%20Primates&cmd=DetailsSearch" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">PubMed</a>]</p><p>No publication is currently available.</p></div></div><div id="N4AMT99mTc.Human_Studies"><h2 id="_N4AMT99mTc_Human_Studies_">Human Studies</h2><p>[<a href="/pubmed?term=99mTc-N4-AMT%20Human%20Studies&cmd=DetailsSearch" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">PubMed</a>]</p><p>No publication is currently available.</p></div><div id="N4AMT99mTc.Supplemental_Information"><h2 id="_N4AMT99mTc_Supplemental_Information_">Supplemental Information</h2><p>[<a href="/books/n/micad/disclaimer/?report=reader">Disclaimers</a>]</p><p>No information is currently available.</p></div><div id="N4AMT99mTc.NIH_Support"><h2 id="_N4AMT99mTc_NIH_Support_">NIH Support</h2><p>A part of the studies reported in this chapter were funded by a National Institutes of Health grant CA16672.</p></div><div id="N4AMT99mTc.References"><h2 id="_N4AMT99mTc_References_">References</h2><dl class="temp-labeled-list"><dl class="bkr_refwrap"><dt>1.</dt><dd><div class="bk_ref" id="N4AMT99mTc.REF.1">Kong F.L., Ali M.S., Zhang Y., Oh C.S., Yu D.F., Chanda M., Yang D.J.
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<em>Synthesis and evaluation of amino acid-based radiotracer 99mTc-N4-AMT for breast cancer imaging.</em>
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<span><span class="ref-journal">J Biomed Biotechnol. </span>2011;<span class="ref-vol">2011</span>:276907.</span> [<a href="/pmc/articles/PMC3085329/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC3085329</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/21541217" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 21541217</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>2.</dt><dd><div class="bk_ref" id="N4AMT99mTc.REF.2">la Fougere C., Suchorska B., Bartenstein P., Kreth F.W., Tonn J.C.
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<em>Molecular imaging of gliomas with PET: opportunities and limitations.</em>
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<span><span class="ref-journal">Neuro Oncol. </span>2011;<span class="ref-vol">13</span>(8):806–19.</span> [<a href="/pmc/articles/PMC3145468/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC3145468</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/21757446" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 21757446</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>3.</dt><dd><div class="bk_ref" id="N4AMT99mTc.REF.3">Ganapathy V., Thangaraju M., Prasad P.D.
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<em>Nutrient transporters in cancer: relevance to Warburg hypothesis and beyond.</em>
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<span><span class="ref-journal">Pharmacol Ther. </span>2009;<span class="ref-vol">121</span>(1):29–40.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/18992769" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 18992769</span></a>]</div></dd></dl></dl></div><div id="bk_toc_contnr"></div></div></div><div class="fm-sec"><h2 id="_NBK82378_pubdet_">Publication Details</h2><h3>Author Information and Affiliations</h3><div class="contrib half_rhythm"><span itemprop="author">Arvind Chopra</span>, PhD<div class="affiliation small">National Center for Biotechnology Information, NLM, Bethesda, MD 20894<div><span class="email-label">Email: </span><a href="mailto:dev@null" data-email="vog.hin.mln.ibcn@dacim" class="oemail">vog.hin.mln.ibcn@dacim</a></div></div></div><h3>Publication History</h3><p class="small">Created: <span itemprop="datePublished">October 26, 2011</span>; Last Update: <span itemprop="dateModified">December 1, 2011</span>.</p><h3>Copyright</h3><div><div class="half_rhythm"><a href="/books/about/copyright/">Copyright Notice</a></div></div><h3>Publisher</h3><p><a href="http://www.ncbi.nlm.nih.gov/" ref="pagearea=page-banner&targetsite=external&targetcat=link&targettype=publisher">National Center for Biotechnology Information (US)</a>, Bethesda (MD)</p><h3>NLM Citation</h3><p>Chopra A. 99mTc-Labeled O-[3-(1,4,8,11-tetraazabicyclohexadecane)-propyl]-α-methyl tyrosine. 2011 Oct 26 [Updated 2011 Dec 1]. In: Molecular Imaging and Contrast Agent Database (MICAD) [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2004-2013. <span class="bk_cite_avail"></span></p></div><div class="small-screen-prev"><a href="/books/n/micad/K49maDABHERTc99m/?report=reader"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 100 100" preserveAspectRatio="none"><path d="M75,30 c-80,60 -80,0 0,60 c-30,-60 -30,0 0,-60"></path><text x="20" y="28" textLength="60" style="font-size:25px">Prev</text></svg></a></div><div class="small-screen-next"><a href="/books/n/micad/EC2099mTc/?report=reader"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 100 100" preserveAspectRatio="none"><path d="M25,30c80,60 80,0 0,60 c30,-60 30,0 0,-60"></path><text x="20" y="28" textLength="60" style="font-size:25px">Next</text></svg></a></div></article><article data-type="table-wrap" id="figobN4AMT99mTcTncchemicalname99mtclabele"><div id="N4AMT99mTc.T.nc_chemical_name99mtclabele" class="table"><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK82378/table/N4AMT99mTc.T.nc_chemical_name99mtclabele/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__N4AMT99mTc.T.nc_chemical_name99mtclabele_lrgtbl__"><table><tbody><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Chemical name:</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"><sup>99m</sup>Tc-Labeled O-[3-(1,4,8,11-tetraazabicyclohexadecane)-propyl]-α-methyl tyrosine</td><td rowspan="9" colspan="1" style="text-align:center;vertical-align:middle;">
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<a href="https://pubchem.ncbi.nlm.nih.gov/substance/126920290" title="View this structure in PubChem" class="img_link" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem"><img src="https://pubchem.ncbi.nlm.nih.gov/image/imgsrv.fcgi?t=l&sid=126920290" alt="image 126920290 in the ncbi pubchem database" /></a>
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</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Abbreviated name:</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">[<sup>99m</sup>Tc]-N4-AMT</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Synonym:</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Agent Category:</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Compound</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Target:</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">L-type amino acid transporter</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Target Category:</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Transporter</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Method of detection:</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Single-photon emission computed tomography (SPECT); gamma planar imaging</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Source of signal / contrast:</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"><sup>99m</sup>Tc</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Activation:</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">No</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Studies:</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Click on above structure of N4-AMT for information in <a href="http://pubchem.ncbi.nlm.nih.gov/" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">PubChem</a>.</td></tr></tbody></table></div></div></article></div><div id="jr-scripts"><script src="/corehtml/pmc/jatsreader/ptpmc_3.22/js/libs.min.js"> </script><script src="/corehtml/pmc/jatsreader/ptpmc_3.22/js/jr.min.js"> </script></div></div>
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