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<div class="pre-content"><div><div class="bk_prnt"><p class="small">NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.</p><p>Molecular Imaging and Contrast Agent Database (MICAD) [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2004-2013. </p></div><div class="iconblock clearfix whole_rhythm no_top_margin bk_noprnt"><a class="img_link icnblk_img" title="Table of Contents Page" href="/books/n/micad/"><img class="source-thumb" src="/corehtml/pmc/pmcgifs/bookshelf/thumbs/th-micad-lrg.png" alt="Cover of Molecular Imaging and Contrast Agent Database (MICAD)" height="100px" width="80px" /></a><div class="icnblk_cntnt eight_col"><h2>Molecular Imaging and Contrast Agent Database (MICAD) [Internet].</h2><a data-jig="ncbitoggler" href="#__NBK23405_dtls__">Show details</a><div style="display:none" class="ui-widget" id="__NBK23405_dtls__"><div>Bethesda (MD): <a href="https://www.ncbi.nlm.nih.gov/" ref="pagearea=page-banner&targetsite=external&targetcat=link&targettype=publisher">National Center for Biotechnology Information (US)</a>; 2004-2013.</div></div><div class="half_rhythm"><ul class="inline_list"><li style="margin-right:1em"><a class="bk_cntns" href="/books/n/micad/">Contents</a></li></ul></div><div class="bk_noprnt"><form method="get" action="/books/n/micad/" id="bk_srch"><div class="bk_search"><label for="bk_term" class="offscreen_noflow">Search term</label><input type="text" title="Search this book" id="bk_term" name="term" value="" data-jig="ncbiclearbutton" /> <input type="submit" class="jig-ncbibutton" value="Search this book" submit="false" style="padding: 0.1em 0.4em;" /></div></form></div></div><div class="icnblk_cntnt two_col"><div class="pagination bk_noprnt"><a class="active page_link prev" href="/books/n/micad/MPT11C/" title="Previous page in this title">< Prev</a><a class="active page_link next" href="/books/n/micad/SA4503C11/" title="Next page in this title">Next ></a></div></div></div></div></div>
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<div class="main-content lit-style" itemscope="itemscope" itemtype="http://schema.org/CreativeWork"><div class="meta-content fm-sec"><h1 id="_NBK23405_"><span class="title" itemprop="name">[<i>S</i>-<i>methyl</i>-<sup>11</sup>C]<i>N</i>,<i>N</i>-Dimethyl-4-(6-(methylthio)imidazo[1,2-<i>a</i>]pyridine-2-yl)aniline</span></h1><div itemprop="alternativeHeadline" class="subtitle whole_rhythm">[<sup>11</sup>C]MeS-IMPY</div><p class="contrib-group"><span itemprop="author">Kam Leung</span>, PhD.</p><a data-jig="ncbitoggler" href="#__NBK23405_ai__" style="border:0;text-decoration:none">Author Information and Affiliations</a><div style="display:none" class="ui-widget" id="__NBK23405_ai__"><div class="contrib half_rhythm"><span itemprop="author">Kam Leung</span>, PhD<div class="affiliation small">
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National Center for Biotechnology Information, NLM, NIH, Bethesda, MD,
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<span class="before-email-separator"></span><span class="email-label">Email: </span><a href="mailto:dev@null" data-email="vog.hin.mln.ibcn@dacim" class="oemail">vog.hin.mln.ibcn@dacim</a>
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||
</div></div></div><p class="small">Created: <span itemprop="datePublished">October 6, 2007</span>; Last Update: <span itemprop="dateModified">November 19, 2007</span>.</p></div><div class="jig-ncbiinpagenav body-content whole_rhythm" data-jigconfig="allHeadingLevels: ['h2'],smoothScroll: false" itemprop="text"><div id="MeS-IMPY11C.T1" class="table"><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK23405/table/MeS-IMPY11C.T1/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__MeS-IMPY11C.T1_lrgtbl__"><table><tbody><tr><td rowspan="1" colspan="1" style="text-align:right;vertical-align:top;">
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||
<b>Chemical name:</b>
|
||
</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">[<i>S</i>-<i>methyl</i>-<sup>11</sup>C]<i>N</i>,<i>N</i>-Dimethyl-4-(6-(methylthio)imidazo[1,2-<i>a</i>]pyridine-2-yl)aniline</td><td rowspan="9" colspan="1" style="text-align:left;vertical-align:middle;">
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||
<a href="https://pubchem.ncbi.nlm.nih.gov/substance/26738257" title="View this structure in PubChem" class="img_link" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem"><img src="https://pubchem.ncbi.nlm.nih.gov/image/imgsrv.fcgi?t=l&sid=26738257" alt="image 26738257 in the ncbi pubchem database" /></a>
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</td></tr><tr><td rowspan="1" colspan="1" style="text-align:right;vertical-align:top;">
|
||
<b>Abbreviated name:</b>
|
||
</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">[<sup>11</sup>C]MeS-IMPY</td></tr><tr><td rowspan="1" colspan="1" style="text-align:right;vertical-align:top;">
|
||
<b>Synonym:</b>
|
||
</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td></tr><tr><td rowspan="1" colspan="1" style="text-align:right;vertical-align:top;">
|
||
<b>Agent Category:</b>
|
||
</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Compound</td></tr><tr><td rowspan="1" colspan="1" style="text-align:right;vertical-align:top;">
|
||
<b>Target:</b>
|
||
</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Aggregates of ß-amyloid (Aß) peptides</td></tr><tr><td rowspan="1" colspan="1" style="text-align:right;vertical-align:top;">
|
||
<b>Target Category:</b>
|
||
</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Acceptor binding</td></tr><tr><td rowspan="1" colspan="1" style="text-align:right;vertical-align:top;">
|
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<b>Method of detection:</b>
|
||
</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Positron emission tomography (PET)</td></tr><tr><td rowspan="1" colspan="1" style="text-align:right;vertical-align:top;">
|
||
<b>Source of signal:</b>
|
||
</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"><sup>11</sup>C</td></tr><tr><td rowspan="1" colspan="1" style="text-align:right;vertical-align:top;">
|
||
<b>Activation:</b>
|
||
</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">No</td></tr><tr><td rowspan="1" colspan="1" style="text-align:right;vertical-align:top;">
|
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<b>Studies:</b>
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||
</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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||
<ul class="simple-list"><li class="half_rhythm"><div>
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<img alt="Checkbox" src="/corehtml/pmc/css/bookshelf/2.26/img/studies.checkbox.png" />
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||
<i>In vitro</i>
|
||
|
||
</div></li></ul>
|
||
<ul class="simple-list"><li class="half_rhythm"><div>
|
||
<img alt="Checkbox" src="/corehtml/pmc/css/bookshelf/2.26/img/studies.checkbox.png" /> Non-human primates
|
||
</div></li></ul>
|
||
<br />
|
||
</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Click on the above structure for additional information in <a href="http://pubchem.ncbi.nlm.nih.gov" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">PubChem</a>.</td></tr></tbody></table></div></div><div id="MeS-IMPY11C.Background"><h2 id="_MeS-IMPY11C_Background_">Background</h2><p>[<a href="/sites/entrez?Db=pubmed&Cmd=DetailsSearch&Term=MeS-IMPY" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">PubMed</a>]</p><p>Alzheimer’s disease (AD) is a major neurodegenerative disease associated with an irreversible decline of mental functions and with cognitive impairment (<a class="bk_pop" href="#MeS-IMPY11C.EXTYLES.1">1</a>). It is characterized pathologically by neuronal loss with the presence in the brain of senile plaques of β-amyloid (Aβ) peptides and intracellular neurofibrillary tangles of filaments that contain the hyperphosphorylated protein tau (<a class="bk_pop" href="#MeS-IMPY11C.EXTYLES.2">2</a>, <a class="bk_pop" href="#MeS-IMPY11C.EXTYLES.3">3</a>). Accelerated deposition of Aβ deposits seems to be a key risk factor associated with AD.</p><p>Early diagnosis of AD is important for treatment consideration and disease management (<a class="bk_pop" href="#MeS-IMPY11C.EXTYLES.4">4</a>). Several radioligands [<a href="/sites/entrez?Db=pubmed&Cmd=DetailsSearch&Term=amyloid+plaque+and+radioisotopes" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">PubMed</a>] for positron emission tomography (PET) have been developed (<a class="bk_pop" href="#MeS-IMPY11C.EXTYLES.5">5-7</a>) and tested in humans as <i>in vivo</i> diagnostic tools for imaging and measuring the formation of Aβ deposits (<a class="bk_pop" href="#MeS-IMPY11C.EXTYLES.7">7</a>). The first agent successfully used in human studies was <a href="/books/n/micad/FDDNP18F/">[<sup>18</sup>F]FDDNP</a> (<a class="bk_pop" href="#MeS-IMPY11C.EXTYLES.8">8</a>), a malonitrile derivative found to bind to both neurofibrillary tangles and Aβ plaques. The second successful agent was <a href="/books/n/micad/PIB11C/">[<sup>11</sup>C]PIB</a> (<a class="bk_pop" href="#MeS-IMPY11C.EXTYLES.9">9</a>), also known as Pittsburgh Compound B or [<sup>11</sup>C]6-OH-BTA-1, which showed marked retention in areas of the cortex known to contain substantial amounts of Aβ deposits. The third PET radioligand successfully tested in humans was [<sup>11</sup>C]4-<i>N</i>-methylamino-4’-hydroxystilbene (<a href="/books/n/micad/SB1311C/">[<sup>11</sup>C]SB-13</a>), a stilbene derivative that exhibits good binding affinities for Aβ aggregates <i>in vitro</i>, moderate lipophilicity, high initial brain uptake in the normal rat cortex, and a rapid washout (<a class="bk_pop" href="#MeS-IMPY11C.EXTYLES.10">10</a>).</p><p>[<sup>125</sup>I]6-Iodo-2-(4’-dimethylamino)-phenyl-imidazo[1,2-<i>a</i>]pyridine (<a href="/books/n/micad/IMPY/">[<sup>125</sup>I]IMPY</a>) displays a high specific binding for Aβ plaques and favorable brain uptake kinetics in rodents for single-photon emission computed tomography (SPECT). [<i>S</i>-<i>methyl</i>-<sup>11</sup>C]<i>N</i>,<i>N</i>-Dimethyl-4-(6-(methylthio)imidazo[1,2-<i>a</i>]pyridine-2-yl)aniline ([<sup>11</sup>C]MeS-IMPY) has been synthesized as an <i>S</i>-methyl analog of [<sup>125</sup>I]IMPY and is currently being studied as a PET radioligand for Aβ plaques (<a class="bk_pop" href="#MeS-IMPY11C.EXTYLES.11">11</a>).</p></div><div id="MeS-IMPY11C.Synthesis"><h2 id="_MeS-IMPY11C_Synthesis_">Synthesis</h2><p>[<a href="/entrez/query.fcgi?cmd=PureSearch&db=pubmed&details_term=MeS-IMPY%20and%20synthesis" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">PubMed</a>]</p><p>[<sup>11</sup>C]MeS-IMPY was synthesized from its precursor by <i>S</i>-methylation in acetonitrile with the use of <sup>11</sup>C-methyl iodide (80°C for 5 min) (<a class="bk_pop" href="#MeS-IMPY11C.EXTYLES.11">11</a>). [<sup>11</sup>C]MeS-IMPY was purified by reversed-phase high-performance liquid chromatography with >98% radiochemical purity. The radiochemical yields (decay-corrected) on the basis of [<sup>11</sup>C]CO<sub>2</sub> were 10–15% , and the specific activities were 37–148 GBq/µmol (1.0–4.0 Ci/µmol) at the end of synthesis.</p></div><div id="MeS-IMPY11C.In_Vitro_Studies_Tes"><h2 id="_MeS-IMPY11C_In_Vitro_Studies_Tes_"><i>In Vitro</i> Studies: Testing in Cells and Tissues</h2><p>[<a href="/entrez/query.fcgi?cmd=PureSearch&db=pubmed&details_term=MeS-IMPY%20and%20in%20vitro" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">PubMed</a>]</p><p>MeS-IMPY was found to have an inhibition constant (<i>K</i><sub>i</sub>) value of 7.93 nM using human AD brain homogenates (<a class="bk_pop" href="#MeS-IMPY11C.EXTYLES.11">11</a>). MeS-IMPY exhibited a moderate lipophilicity (log <i>D</i> value of 4.1 at pH 7.4). These values are comparable to those of IMPY (<i>K</i><sub>i</sub> value of 8.95 nM and log <i>D</i> value of 3.58).</p></div><div id="MeS-IMPY11C.Animal_Studies"><h2 id="_MeS-IMPY11C_Animal_Studies_">Animal Studies</h2><div id="MeS-IMPY11C.Rodents"><h3>Rodents</h3><p>[<a href="/entrez/query.fcgi?cmd=PureSearch&db=pubmed&details_term=MeS-IMPY%20and%20rodentia" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">PubMed</a>]</p><p>No publication is currently available.</p></div><div id="MeS-IMPY11C.Other_NonPrimate_Mam"><h3>Other Non-Primate Mammals</h3><p>[<a href="/entrez/query.fcgi?cmd=PureSearch&db=pubmed&details_term=MeS-IMPY%20and%20%28dog%20or%20pig%20or%20sheep%20or%20rabbit%29" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">PubMed</a>]</p><p>No publication is currently available.</p></div><div id="MeS-IMPY11C.NonHuman_Primates"><h3>Non-Human Primates</h3><p>[<a href="/entrez/query.fcgi?cmd=PureSearch&db=pubmed&details_term=MeS-IMPY%20and%20%28primate%20not%20human%29" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">PubMed</a>]</p><p>Seneca et al. (<a class="bk_pop" href="#MeS-IMPY11C.EXTYLES.11">11</a>) studied PET imaging in the brains of five young male rhesus monkeys after intravenous injection of 191 ± 75 MBq (5.16 ± 2.03 mCi) [<sup>11</sup>C]MeS-IMPY. Various brain regions exhibited rapid accumulation with rapid decreases thereafter. [<sup>11</sup>C]MeS-IMPY PET images (up to 120 min after injection) showed high standardized uptake values of ~500% and ~600% at 2–3 min in cortical regions and the cerebellum, respectively. The brain uptake of [<sup>11</sup>C]MeS-IMPY was widespread and quite uniform across all cortical regions. Radioactivity rapidly washed out of the brain, with 20% of peak activity remaining at 40 min. Regional brain radioactivity fit well into a one-tissue compartment model. The average volume of distribution in all brain regions was 7.66 ± 2.14 ml/cm<sup>3</sup> (<i>n</i> = 4). The organs with the highest radiation exposure (μSv/MBq and mrem/mCi) were the gallbladder wall (33.4 and 123.5), urinary bladder (17.0 and 62.9), lungs (12.9 and 47.8), kidneys (11.7 and 43.4), and liver (10.7 and 39.4), with a resulting effective dose of 4.9 μSv/MBq (18.0 mrem/mCi).</p></div></div><div id="MeS-IMPY11C.Human_Studies"><h2 id="_MeS-IMPY11C_Human_Studies_">Human Studies</h2><p>[<a href="/entrez/query.fcgi?cmd=PureSearch&db=pubmed&details_term=MeS-IMPY%20and%20human" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">PubMed</a>]</p><p>No publication is currently available.</p></div><div id="MeS-IMPY11C.NIH_Support"><h2 id="_MeS-IMPY11C_NIH_Support_">NIH Support</h2><p>Intramural Research Program</p></div><div id="MeS-IMPY11C.references"><h2 id="_MeS-IMPY11C_references_">References</h2><dl class="temp-labeled-list"><dt>1.</dt><dd><div class="bk_ref" id="MeS-IMPY11C.EXTYLES.1">Forstl H. , Kurz A. Clinical features of Alzheimer's disease. <span><span class="ref-journal">Eur Arch Psychiatry Clin Neurosci. </span>1999;<span class="ref-vol">
|
||
<strong>249</strong>
|
||
</span>(6):288–90.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/10653284" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 10653284</span></a>]</div></dd><dt>2.</dt><dd><div class="bk_ref" id="MeS-IMPY11C.EXTYLES.2">Hardy J. The relationship between amyloid and tau. <span><span class="ref-journal">J Mol Neurosci. </span>2003;<span class="ref-vol">
|
||
<strong>20</strong>
|
||
</span>(2):203–6.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/12794314" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 12794314</span></a>]</div></dd><dt>3.</dt><dd><div class="bk_ref" id="MeS-IMPY11C.EXTYLES.3">Brandt R. , Leschik J. Functional interactions of tau and their relevance for Alzheimer's disease. <span><span class="ref-journal">Curr Alzheimer Res. </span>2004;<span class="ref-vol">
|
||
<strong>1</strong>
|
||
</span>(4):255–69.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/15975055" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 15975055</span></a>]</div></dd><dt>4.</dt><dd><div class="bk_ref" id="MeS-IMPY11C.EXTYLES.4">de Leon M.J. , DeSanti S. , Zinkowski R. , Mehta P.D. , Pratico D. , Segal S. , Clark C. , Kerkman D. , DeBernardis J. , Li J. , Lair L. , Reisberg B. , Tsui W. , Rusinek H. MRI and CSF studies in the early diagnosis of Alzheimer's disease. <span><span class="ref-journal">J Intern Med. </span>2004;<span class="ref-vol">
|
||
<strong>256</strong>
|
||
</span>(3):205–23.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/15324364" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 15324364</span></a>]</div></dd><dt>5.</dt><dd><div class="bk_ref" id="MeS-IMPY11C.EXTYLES.5">Nordberg A. PET imaging of amyloid in Alzheimer's disease. <span><span class="ref-journal">Lancet Neurol. </span>2004;<span class="ref-vol">
|
||
<strong>3</strong>
|
||
</span>(9):519–27.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/15324720" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 15324720</span></a>]</div></dd><dt>6.</dt><dd><div class="bk_ref" id="MeS-IMPY11C.EXTYLES.6">Bacskai B.J. , Hickey G.A. , Skoch J. , Kajdasz S.T. , Wang Y. , Huang G.F. , Mathis C.A. , Klunk W.E. , Hyman B.T. Four-dimensional multiphoton imaging of brain entry, amyloid binding, and clearance of an amyloid-beta ligand in transgenic mice. <span><span class="ref-journal">Proc Natl Acad Sci U S A. </span>2003;<span class="ref-vol">
|
||
<strong>100</strong>
|
||
</span>(21):12462–7.</span> [<a href="/pmc/articles/PMC218780/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC218780</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/14517353" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 14517353</span></a>]</div></dd><dt>7.</dt><dd><div class="bk_ref" id="MeS-IMPY11C.EXTYLES.7">Wu C. , Pike V.W. , Wang Y. Amyloid imaging: from benchtop to bedside. <span><span class="ref-journal">Curr Top Dev Biol. </span>2005;<span class="ref-vol">
|
||
<strong>70</strong>
|
||
</span>:171–213.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/16338342" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 16338342</span></a>]</div></dd><dt>8.</dt><dd><div class="bk_ref" id="MeS-IMPY11C.EXTYLES.8">Shoghi-Jadid K. , Small G.W. , Agdeppa E.D. , Kepe V. , Ercoli L.M. , Siddarth P. , Read S. , Satyamurthy N. , Petric A. , Huang S.C. , Barrio J.R. Localization of neurofibrillary tangles and beta-amyloid plaques in the brains of living patients with Alzheimer disease. <span><span class="ref-journal">Am J Geriatr Psychiatry. </span>2002;<span class="ref-vol">
|
||
<strong>10</strong>
|
||
</span>(1):24–35.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/11790632" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 11790632</span></a>]</div></dd><dt>9.</dt><dd><div class="bk_ref" id="MeS-IMPY11C.EXTYLES.9">Klunk W.E. , Engler H. , Nordberg A. , Wang Y. , Blomqvist G. , Holt D.P. , Bergstrom M. , Savitcheva I. , Huang G.F. , Estrada S. , Ausen B. , Debnath M.L. , Barletta J. , Price J.C. , Sandell J. , Lopresti B.J. , Wall A. , Koivisto P. , Antoni G. , Mathis C.A. , Langstrom B. Imaging brain amyloid in Alzheimer's disease with Pittsburgh Compound-B. <span><span class="ref-journal">Ann Neurol. </span>2004;<span class="ref-vol">
|
||
<strong>55</strong>
|
||
</span>(3):306–19.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/14991808" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 14991808</span></a>]</div></dd><dt>10.</dt><dd><div class="bk_ref" id="MeS-IMPY11C.EXTYLES.10">Ono M. , Wilson A. , Nobrega J. , Westaway D. , Verhoeff P. , Zhuang Z.P. , Kung M.P. , Kung H.F. 11C-labeled stilbene derivatives as Abeta-aggregate-specific PET imaging agents for Alzheimer's disease. <span><span class="ref-journal">Nucl Med Biol. </span>2003;<span class="ref-vol">
|
||
<strong>30</strong>
|
||
</span>(6):565–71.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/12900282" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 12900282</span></a>]</div></dd><dt>11.</dt><dd><div class="bk_ref" id="MeS-IMPY11C.EXTYLES.11">Seneca N. , Cai L. , Liow J.S. , Zoghbi S.S. , Gladding R.L. , Hong J. , Pike V.W. , Innis R.B. Brain and whole-body imaging in nonhuman primates with [(11)C]MeS-IMPY, a candidate radioligand for beta-amyloid plaques. <span><span class="ref-journal">Nucl Med Biol. </span>2007;<span class="ref-vol">
|
||
<strong>34</strong>
|
||
</span>(6):681–9.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/17707808" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 17707808</span></a>]</div></dd></dl></div><div id="bk_toc_contnr"></div></div></div>
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<div class="post-content"><div><div class="half_rhythm"><a href="/books/about/copyright/">Copyright Notice</a></div><div class="small"><span class="label">Bookshelf ID: NBK23405</span><span class="label">PMID: <a href="https://pubmed.ncbi.nlm.nih.gov/20641606" title="PubMed record of this page" ref="pagearea=meta&targetsite=entrez&targetcat=link&targettype=pubmed">20641606</a></span></div><div style="margin-top:2em" class="bk_noprnt"><a class="bk_cntns" href="/books/n/micad/">Contents</a><div class="pagination bk_noprnt"><a class="active page_link prev" href="/books/n/micad/MPT11C/" title="Previous page in this title">< Prev</a><a class="active page_link next" href="/books/n/micad/SA4503C11/" title="Next page in this title">Next ></a></div></div></div></div>
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<div xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"></div><div class="portlet"><div class="portlet_head"><div class="portlet_title"><h3><span>Views</span></h3></div><a name="Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="PDF_download" id="Shutter"></a></div><div class="portlet_content"><ul xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="simple-list"><li><a href="/books/NBK23405/?report=reader">PubReader</a></li><li><a href="/books/NBK23405/?report=printable">Print View</a></li><li><a data-jig="ncbidialog" href="#_ncbi_dlg_citbx_NBK23405" data-jigconfig="width:400,modal:true">Cite this Page</a><div id="_ncbi_dlg_citbx_NBK23405" style="display:none" title="Cite this Page"><div class="bk_tt">Leung K. [S-methyl-11C]N,N-Dimethyl-4-(6-(methylthio)imidazo[1,2-a]pyridine-2-yl)aniline. 2007 Oct 6 [Updated 2007 Nov 19]. In: Molecular Imaging and Contrast Agent Database (MICAD) [Internet]. 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