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<meta name="robots" content="INDEX,FOLLOW,NOARCHIVE" /><meta name="citation_inbook_title" content="Molecular Imaging and Contrast Agent Database (MICAD) [Internet]" /><meta name="citation_title" content="2-[11C]Methyl-6-(2-phenylethynyl)pyridine" /><meta name="citation_publisher" content="National Center for Biotechnology Information (US)" /><meta name="citation_date" content="2008/02/04" /><meta name="citation_author" content="Kenneth T. Cheng" /><meta name="citation_pmid" content="20641559" /><meta name="citation_fulltext_html_url" content="https://www.ncbi.nlm.nih.gov/books/NBK23358/" /><link rel="schema.DC" href="http://purl.org/DC/elements/1.0/" /><meta name="DC.Title" content="2-[11C]Methyl-6-(2-phenylethynyl)pyridine" /><meta name="DC.Type" content="Text" /><meta name="DC.Publisher" content="National Center for Biotechnology Information (US)" /><meta name="DC.Contributor" content="Kenneth T. Cheng" /><meta name="DC.Date" content="2008/02/04" /><meta name="DC.Identifier" content="https://www.ncbi.nlm.nih.gov/books/NBK23358/" /><meta name="description" content="2-[11C]Methyl-6-(2-phenylethynyl)pyridine ([11C]MPEP) is a radioligand developed for positron emission tomography (PET) imaging of metabotropic glutamate (mGlu) receptor subtype 5 (mGluR5 or mGluR5) in the central nervous system (CNS) (1). 11C is a positron emitter with a physical half-life (t½) of 20.3 min." /><meta name="og:title" content="2-[11C]Methyl-6-(2-phenylethynyl)pyridine" /><meta name="og:type" content="book" /><meta name="og:description" content="2-[11C]Methyl-6-(2-phenylethynyl)pyridine ([11C]MPEP) is a radioligand developed for positron emission tomography (PET) imaging of metabotropic glutamate (mGlu) receptor subtype 5 (mGluR5 or mGluR5) in the central nervous system (CNS) (1). 11C is a positron emitter with a physical half-life (t½) of 20.3 min." /><meta name="og:url" content="https://www.ncbi.nlm.nih.gov/books/NBK23358/" /><meta name="og:site_name" content="NCBI Bookshelf" /><meta name="og:image" content="https://www.ncbi.nlm.nih.gov/corehtml/pmc/pmcgifs/bookshelf/thumbs/th-micad-lrg.png" /><meta name="twitter:card" content="summary" /><meta name="twitter:site" content="@ncbibooks" /><meta name="bk-non-canon-loc" content="/books/n/micad/MPEP11C/" /><link rel="canonical" href="https://www.ncbi.nlm.nih.gov/books/NBK23358/" /><link rel="stylesheet" href="/corehtml/pmc/css/figpopup.css" type="text/css" media="screen" /><link rel="stylesheet" href="/corehtml/pmc/css/bookshelf/2.26/css/books.min.css" type="text/css" /><link rel="stylesheet" href="/corehtml/pmc/css/bookshelf/2.26/css/books_print.min.css" type="text/css" media="print" /><style type="text/css">p a.figpopup{display:inline !important} .bk_tt {font-family: monospace} .first-line-outdent .bk_ref {display: inline} .body-content h2, .body-content .h2 {border-bottom: 1px solid #97B0C8} .body-content h2.inline {border-bottom: none} a.page-toc-label , .jig-ncbismoothscroll a {text-decoration:none;border:0 !important} .temp-labeled-list .graphic {display:inline-block !important} .temp-labeled-list img{width:100%}</style><script type="text/javascript" src="/corehtml/pmc/js/jquery.hoverIntent.min.js"> </script><script type="text/javascript" src="/corehtml/pmc/js/common.min.js?_=3.18"> </script><script type="text/javascript" src="/corehtml/pmc/js/large-obj-scrollbars.min.js"> </script><script type="text/javascript">window.name="mainwindow";</script><script type="text/javascript" src="/corehtml/pmc/js/bookshelf/2.26/book-toc.min.js"> </script><script type="text/javascript" src="/corehtml/pmc/js/bookshelf/2.26/books.min.js"> </script><meta name="book-collection" content="NONE" />
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<div class="pre-content"><div><div class="bk_prnt"><p class="small">NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.</p><p>Molecular Imaging and Contrast Agent Database (MICAD) [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2004-2013. </p></div><div class="iconblock clearfix whole_rhythm no_top_margin bk_noprnt"><a class="img_link icnblk_img" title="Table of Contents Page" href="/books/n/micad/"><img class="source-thumb" src="/corehtml/pmc/pmcgifs/bookshelf/thumbs/th-micad-lrg.png" alt="Cover of Molecular Imaging and Contrast Agent Database (MICAD)" height="100px" width="80px" /></a><div class="icnblk_cntnt eight_col"><h2>Molecular Imaging and Contrast Agent Database (MICAD) [Internet].</h2><a data-jig="ncbitoggler" href="#__NBK23358_dtls__">Show details</a><div style="display:none" class="ui-widget" id="__NBK23358_dtls__"><div>Bethesda (MD): <a href="https://www.ncbi.nlm.nih.gov/" ref="pagearea=page-banner&targetsite=external&targetcat=link&targettype=publisher">National Center for Biotechnology Information (US)</a>; 2004-2013.</div></div><div class="half_rhythm"><ul class="inline_list"><li style="margin-right:1em"><a class="bk_cntns" href="/books/n/micad/">Contents</a></li></ul></div><div class="bk_noprnt"><form method="get" action="/books/n/micad/" id="bk_srch"><div class="bk_search"><label for="bk_term" class="offscreen_noflow">Search term</label><input type="text" title="Search this book" id="bk_term" name="term" value="" data-jig="ncbiclearbutton" /> <input type="submit" class="jig-ncbibutton" value="Search this book" submit="false" style="padding: 0.1em 0.4em;" /></div></form></div></div><div class="icnblk_cntnt two_col"><div class="pagination bk_noprnt"><a class="active page_link prev" href="/books/n/micad/A-582941-11C/" title="Previous page in this title">< Prev</a><a class="active page_link next" href="/books/n/micad/TEIMD-11C/" title="Next page in this title">Next ></a></div></div></div></div></div>
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<div class="main-content lit-style" itemscope="itemscope" itemtype="http://schema.org/CreativeWork"><div class="meta-content fm-sec"><h1 id="_NBK23358_"><span class="title" itemprop="name">2-[<sup>11</sup>C]Methyl-6-(2-phenylethynyl)pyridine </span></h1><div itemprop="alternativeHeadline" class="subtitle whole_rhythm">[<sup>11</sup>C]MPEP</div><p class="contrib-group"><span itemprop="author">Kenneth T. Cheng</span>, PhD.</p><a data-jig="ncbitoggler" href="#__NBK23358_ai__" style="border:0;text-decoration:none">Author Information and Affiliations</a><div style="display:none" class="ui-widget" id="__NBK23358_ai__"><div class="contrib half_rhythm"><span itemprop="author">Kenneth T. Cheng</span>, PhD<div class="affiliation small">
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National Center for Biotechnology Information, NLM, NIH, Bethesda, MD,
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<span class="before-email-separator"></span><span class="email-label">Email: </span><a href="mailto:dev@null" data-email="vog.hin.mln.ibcn@dacim" class="oemail">vog.hin.mln.ibcn@dacim</a>
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||
</div></div></div><p class="small">Created: <span itemprop="datePublished">November 15, 2007</span>; Last Update: <span itemprop="dateModified">February 4, 2008</span>.</p></div><div class="jig-ncbiinpagenav body-content whole_rhythm" data-jigconfig="allHeadingLevels: ['h2'],smoothScroll: false" itemprop="text"><div id="MPEP11C.T1" class="table"><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK23358/table/MPEP11C.T1/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__MPEP11C.T1_lrgtbl__"><table><tbody><tr><td rowspan="1" colspan="1" style="text-align:right;vertical-align:top;">
|
||
<b>Chemical name:</b>
|
||
</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">2-[<sup>11</sup>C]Methyl-6-(2-phenylethynyl)pyridine</td><td rowspan="9" colspan="1" style="text-align:left;vertical-align:middle;">
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||
<a href="https://pubchem.ncbi.nlm.nih.gov/substance/46504141" title="View this structure in PubChem" class="img_link" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem"><img src="https://pubchem.ncbi.nlm.nih.gov/image/imgsrv.fcgi?t=l&sid=46504141" alt="image 46504141 in the ncbi pubchem database" /></a>
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</td></tr><tr><td rowspan="1" colspan="1" style="text-align:right;vertical-align:top;">
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<b>Abbreviated name:</b>
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</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">[<sup>11</sup>C]MPEP</td></tr><tr><td rowspan="1" colspan="1" style="text-align:right;vertical-align:top;">
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<b>Synonym:</b>
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</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td></tr><tr><td rowspan="1" colspan="1" style="text-align:right;vertical-align:top;">
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<b>Agent Category:</b>
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</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Compound</td></tr><tr><td rowspan="1" colspan="1" style="text-align:right;vertical-align:top;">
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<b>Target:</b>
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</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Metabotropic glutamate subtype 5 (mGlu5) receptor (mGluR5 or mGluR<sub>5</sub>)</td></tr><tr><td rowspan="1" colspan="1" style="text-align:right;vertical-align:top;">
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<b>Target Category:</b>
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</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Receptor binding</td></tr><tr><td rowspan="1" colspan="1" style="text-align:right;vertical-align:top;">
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<b>Method of detection:</b>
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</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Positron emission tomography (PET)</td></tr><tr><td rowspan="1" colspan="1" style="text-align:right;vertical-align:top;">
|
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<b>Source of signal:</b>
|
||
</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"><sup>11</sup>C</td></tr><tr><td rowspan="1" colspan="1" style="text-align:right;vertical-align:top;">
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<b>Activation:</b>
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</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">No</td></tr><tr><td rowspan="1" colspan="1" style="text-align:right;vertical-align:top;">
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<b>Studies:</b>
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</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<ul class="simple-list"><li class="half_rhythm"><div>
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<img alt="Checkbox" src="/corehtml/pmc/css/bookshelf/2.26/img/studies.checkbox.png" />
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||
<i>In vitro</i>
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||
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||
</div></li></ul>
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||
<ul class="simple-list"><li class="half_rhythm"><div>
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||
<img alt="Checkbox" src="/corehtml/pmc/css/bookshelf/2.26/img/studies.checkbox.png" /> Rodents
|
||
</div></li></ul>
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||
<br />
|
||
</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Click on the above structure for additional information in <a href="http://pubchem.ncbi.nlm.nih.gov" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">PubChem</a>.</td></tr></tbody></table></div></div><div id="MPEP11C.Background"><h2 id="_MPEP11C_Background_">Background</h2><p>[<a href="/sites/entrez?Db=pubmed&Cmd=DetailsSearch&Term=metabotropic+glutamate+receptor+subtype+5+PET+ligand" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">PubMed</a>]</p><p>2-[<sup>11</sup>C]Methyl-6-(2-phenylethynyl)pyridine ([<sup>11</sup>C]MPEP) is a radioligand developed for positron emission tomography (PET) imaging of metabotropic glutamate (mGlu) receptor subtype 5 (mGluR5 or mGluR<sub>5</sub>) in the central nervous system (CNS) (<a class="bk_pop" href="#MPEP11C.REF.1">1</a>). <sup>11</sup>C is a positron emitter with a physical half-life (<i>t</i><sub>½</sub>) of 20.3 min.</p><p>Glutamate is a major excitatory neurotransmitter at CNS synapses. Many neuroanatomical CNS projection pathways contain glutamatergic neurons (<a class="bk_pop" href="#MPEP11C.REF.2">2</a>). Glutamate produces its excitatory effects by acting on cell-surface ionotropic glutamate or mGluRs (<a class="bk_pop" href="#MPEP11C.REF.3">3</a>). The mGluRs are G-protein–coupled receptors, and the eight mGluR subtypes are further subdivided into groups I, II, and III. The group I receptors include mGluR1 and mGluR5, and they are found predominantly in postsynaptic locations. The mGluR5s are found with high to moderate density in the frontal cortex, caudate, putamen, nucleus accumbens, olfactory tubercle, hippocampus, and dorsal horn of the spinal cord, whereas the density in the cerebellum is low. These receptors are coupled to phospholipase C and up- or downregulate neuronal excitability. They have been implicated in a variety of diseases in the CNS, including anxiety, depression, schizophrenia, Parkinson’s disease, and drug addiction or withdrawal. These receptors are also involved in the modulation of various pain states, which makes them attractive targets for therapeutic drug development.</p><p>PET and single-photon emission computed tomography imaging of radioligands that target mGluR5s can be used to visualize and study the CNS mGluR5s in normal and pathological states. Some mGluR5 antagonists have been successfully labeled, but their <i>in vivo</i> visualization has been hampered by high lipophilicity, unfavorable brain uptake kinetics, or high metabolism (<a class="bk_pop" href="#MPEP11C.REF.4">4</a>, <a class="bk_pop" href="#MPEP11C.REF.5">5</a>). MPEP and its methyl analog M-MPEP have been identified as potent and highly selective noncompetitive antagonists for mGlu5 (<a class="bk_pop" href="#MPEP11C.REF.1">1</a>, <a class="bk_pop" href="#MPEP11C.REF.6">6</a>). Yu et al. (<a class="bk_pop" href="#MPEP11C.REF.1">1</a>) synthesized [<sup>11</sup>C]MPEP and demonstrated the feasibility of using it as a PET imaging ligand for <i>in vivo</i> imaging.</p></div><div id="MPEP11C.Synthesis"><h2 id="_MPEP11C_Synthesis_">Synthesis</h2><p>[<a href="/sites/entrez?Db=pubmed&Cmd=DetailsSearch&Term=(metabotropic+glutamate+receptor+subtype+5+PET+ligand)+AND+synthesis" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">PubMed</a>]</p><p>Yu et al. (<a class="bk_pop" href="#MPEP11C.REF.1">1</a>) reported the synthesis of [<sup>11</sup>C]MPEP from its stannyl precursor. The precursor was prepared from 2-bromo-6-(phenylethynyl)pyridine. Briefly, phenylacetylene was added to a mixture of 2,6-dibromopyridine, CuI, PdCl<sub>2</sub>(PPh<sub>3</sub>)<sub>2</sub>, and triethylamine. The mixture was stirred at room temperature for 27 h. The product was then filtered and purified on a silica gel column. The yield of 2-bromo-6-(phenylethynyl)pyridine was 42%. This was then reacted with tetrakis(triphenylphosphine)palladium(0) (Pd(0)) and toluene in a Chemglass cylindrical pressure vessel. A nitrogen stream was bubbled through the solution, and hexamethyldistannane was added. The pressure vessel was then capped and heated to 115–120ºC for 6 h. After filtration on a silica gel column, the residue was stirred for 2 h with saturated aqueous sodium bicarbonate and 35% aqueous hydrogen peroxide to oxidize PPh<sub>3</sub> to PPh<sub>3</sub>O for removal by column chromatography. The yield of the MPEP precursor, 2-(trimethylstannyl)-6-(2-phenylethynyl)pyridine, was 51%. For the radiosynthesis, [<sup>11</sup>C]carbon dioxide ([<sup>11</sup>C]CO<sub>2</sub>) was produced by the <sup>14</sup>N(p, α)<sup>11</sup>C nuclear reaction in nitrogen, and [<sup>11</sup>C]CO<sub>2</sub> was transformed to [<sup>11</sup>C]methyl iodide ([<sup>11</sup>C]CH<sub>3</sub>I) for radiolabeling. The MPEP precursor was reacted with [<sup>11</sup>C]CH<sub>3</sub>I by the rapid Stille coupling reaction of aromatic stannanes. In this reaction, Pd(0) was used as the catalyst in toluene, and the reaction mixture was heated for 5 min at 100ºC. The radiochemical purity was 97.4 ± 2.3% (<i>n</i> = 14), and the specific activity was 40.4 ± 5.0 GBq/μmol (1,093 ± 134 mCi/μmol). The radiochemical yield was 12.6 ± 10.6 mCi at the end of synthesis.</p></div><div id="MPEP11C.In_Vitro_Studies_Tes"><h2 id="_MPEP11C_In_Vitro_Studies_Tes_"><i>In Vitro</i> Studies: Testing in Cells and Tissues</h2><p>[<a href="/sites/entrez?Db=pubmed&Cmd=DetailsSearch&Term=(metabotropic+glutamate+receptor+subtype+5+PET+ligand)+AND+in+vitro" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">PubMed</a>]</p><p>No publication is currently available.</p></div><div id="MPEP11C.Animal_Studies"><h2 id="_MPEP11C_Animal_Studies_">Animal Studies</h2><div id="MPEP11C.Rodents"><h3>Rodents</h3><p>[<a href="/sites/entrez?Db=pubmed&Cmd=DetailsSearch&Term=(metabotropic+glutamate+receptor+subtype+5+PET+ligand)+AND+rodentia" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">PubMed</a>]</p><p>PET imaging was performed in male rats (<a class="bk_pop" href="#MPEP11C.REF.1">1</a>). Each anesthetized rat received 92.91 ± 34.15 MBq (2.51 ± 0.92 mCi) in 0.433 ± 0.163 μg ((2–3 nM)/0.1 ml or 2.3 nmol calculated from the mean specific activity of 1.09 mCi/nmol) by i.v. administration. Imaging showed high and rapid radioactivity accumulation of [<sup>11</sup>C]MPEP in brain areas, including the olfactory bulb, striatum, hippocampus, frontal cortex, and cerebellum. The maximum accumulation occurred in 2–3 min except in the olfactory bulb, where the radioactivity accumulated up to 10 min. The highest accumulation was in the olfactory area, followed by the hippocampus, cortex, and striatum. The radioactivity level ratio of olfactory bulb/cerebellum reached the maximum of 7.0 at 30 min. The radioactivity levels (<i>n</i> = 9) of the whole brain in percentage of the injected dose per cubic centimeter (% ID/cc) obtained from volumetric region-of-interest image analysis were 0.402 ± 0.066 (5 min), 0.223 ± 0.031 (10 min), 0.159 ± 0.018 (20 min), 0.128 ± 0.012 (30 min), 0.112 ± 0.009 (40 min), 0.096 ± 0.053 (50 min), and 0.094 ± 0.048 (60 min). The radioactivity levels (% ID/cc) of the olfactory bulb were 1.060 ± 0.182 (5 min), 1.110 ± 0.040 (10 min), 0.954 ± 0.032 (20 min), 0.821 ± 0.041 (30 min), 0.724 ± 0.058 (40 min), 0.616 ± 0.036 (50 min), and 0.568 ± 0.315 (60 min). When a blocking dose of 10 mg/kg unlabeled MPEP was administered 5 min before the radioligand injection (102.601 ± 18.06 MBq (2.77 ± 0.49 mCi) or 0.490 ± 0.079 μg (2.53 nmol calculated from the mean specific activity of 1.093 mCi/nmol)), the radioactivity levels (<i>n</i> = 4) of the olfactory lobe were decreased by 45.1% at 5 min and 61.5% at 40 min. High radioactivity levels were also observed in the liver, pancreas, and intestine. With the blocking dose of MPEP, the radioactivity levels (%ID/cc) of the duodenum (<i>n</i> = 2) decreased from 0.299 ± 0.083 to 0.131 ± 0.077 at 20 min and from 0.379 ± 0.074 to 0.079 ± 0.038 at 60 min. In another study that used a higher blocking dose at an earlier time point (MPEP 20 mg/kg at 10 s before radioligand injection) in two rats, there was decreased accumulation in all brain areas until 40 min. The radioactivity level decreases in the olfactory area were 80.2 ± 14.5% and 80.0 ± 8.2% at 5 min and 40 min, respectively. In the striatal area, the decreases were 35.8 ± 20.5% and 16.5 ± 14.0% at 5 min and 40 min, respectively.</p><p>In the <i>in vivo</i> metabolism study, [<sup>11</sup>C]MPEP was shown by high-performance liquid chromatography analysis to be rapidly metabolized after administration (<a class="bk_pop" href="#MPEP11C.REF.1">1</a>). The percentage of the radioligand remaining intact in the plasma after administration (<i>n</i> = 2) was 26.2 ± 6.2% at 5 min and 3.5 ± 2.6% at 20 min. No any lipophilic metabolite from [<sup>11</sup>C]MPEP was found.</p></div><div id="MPEP11C.Other_NonPrimate_Mam"><h3>Other Non-Primate Mammals</h3><p>[<a href="/sites/entrez?Db=pubmed&Cmd=DetailsSearch&Term=(metabotropic+glutamate+receptor+subtype+5+PET+ligand)+AND+(dog+OR+rabbit+OR+pig+OR+sheep)" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">PubMed</a>]</p><p>No publication is currently available.</p></div><div id="MPEP11C.NonHuman_Primates"><h3>Non-Human Primates</h3><p>[<a href="/sites/entrez?Db=pubmed&Cmd=DetailsSearch&Term=(metabotropic+glutamate+receptor+subtype+5+PET+ligand)+AND+(primate+NOT+human)" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">PubMed</a>]</p><p>No publication is currently available.</p></div></div><div id="MPEP11C.Human_Studies"><h2 id="_MPEP11C_Human_Studies_">Human Studies</h2><p>[<a href="/sites/entrez?Db=pubmed&Cmd=DetailsSearch&Term=(metabotropic+glutamate+receptor+subtype+5+PET+ligand)+AND+human" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">PubMed</a>]</p><p>No publication is currently available.</p></div><div id="MPEP11C.NIH_Support"><h2 id="_MPEP11C_NIH_Support_">NIH Support</h2><p>NIH/NIBIB grant EB01850.</p></div><div id="MPEP11C.references"><h2 id="_MPEP11C_references_">References</h2><dl class="temp-labeled-list"><dt>1.</dt><dd><div class="bk_ref" id="MPEP11C.REF.1">Yu M. , Tueckmantel W. , Wang X. , Zhu A. , Kozikowski A.P. , Brownell A.L. Methoxyphenylethynyl, methoxypyridylethynyl and phenylethynyl derivatives of pyridine: synthesis, radiolabeling and evaluation of new PET ligands for metabotropic glutamate subtype 5 receptors. <span><span class="ref-journal">Nucl Med Biol. </span>2005;<span class="ref-vol">
|
||
<strong>32</strong>
|
||
</span>(6):631–40.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/16026710" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 16026710</span></a>]</div></dd><dt>2.</dt><dd><div class="bk_ref" id="MPEP11C.REF.2">Pin J.P. , Duvoisin R. The metabotropic glutamate receptors: structure and functions. <span><span class="ref-journal">Neuropharmacology. </span>1995;<span class="ref-vol">
|
||
<strong>34</strong>
|
||
</span>(1):1–26.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/7623957" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 7623957</span></a>]</div></dd><dt>3.</dt><dd><div class="bk_ref" id="MPEP11C.REF.3">Slassi A. , Isaac M. , Edwards L. , Minidis A. , Wensbo D. , Mattsson J. , Nilsson K. , Raboisson P. , McLeod D. , Stormann T.M. , Hammerland L.G. , Johnson E. Recent advances in non-competitive mGlu5 receptor antagonists and their potential therapeutic applications. <span><span class="ref-journal">Curr Top Med Chem. </span>2005;<span class="ref-vol">
|
||
<strong>5</strong>
|
||
</span>(9):897–911.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/16178734" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 16178734</span></a>]</div></dd><dt>4.</dt><dd><div class="bk_ref" id="MPEP11C.REF.4">Ametamey S.M. , Kessler L.J. , Honer M. , Wyss M.T. , Buck A. , Hintermann S. , Auberson Y.P. , Gasparini F. , Schubiger P.A. Radiosynthesis and Preclinical Evaluation of 11C-ABP688 as a Probe for Imaging the Metabotropic Glutamate Receptor Subtype 5. <span><span class="ref-journal">J Nucl Med. </span>2006;<span class="ref-vol">
|
||
<strong>47</strong>
|
||
</span>(4):698–705.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/16595505" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 16595505</span></a>]</div></dd><dt>5.</dt><dd><div class="bk_ref" id="MPEP11C.REF.5">Patel S. , Ndubizu O. , Hamill T. , Chaudhary A. , Burns H.D. , Hargreaves R. , Gibson R.E. Screening cascade and development of potential Positron Emission Tomography radiotracers for mGluR5: in vitro and in vivo characterization. <span><span class="ref-journal">Mol Imaging Biol. </span>2005;<span class="ref-vol">
|
||
<strong>7</strong>
|
||
</span>(4):314–23.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/16080024" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 16080024</span></a>]</div></dd><dt>6.</dt><dd><div class="bk_ref" id="MPEP11C.REF.6">Gasparini F. , Andres H. , Flor P.J. , Heinrich M. , Inderbitzin W. , Lingenhohl K. , Muller H. , Munk V.C. , Omilusik K. , Stierlin C. , Stoehr N. , Vranesic I. , Kuhn R. [(3)H]-M-MPEP, a potent, subtype-selective radioligand for the metabotropic glutamate receptor subtype 5. <span><span class="ref-journal">Bioorg Med Chem Lett. </span>2002;<span class="ref-vol">
|
||
<strong>12</strong>
|
||
</span>(3):407–9.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/11814808" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 11814808</span></a>]</div></dd></dl></div><div id="bk_toc_contnr"></div></div></div>
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<div class="post-content"><div><div class="half_rhythm"><a href="/books/about/copyright/">Copyright Notice</a></div><div class="small"><span class="label">Bookshelf ID: NBK23358</span><span class="label">PMID: <a href="https://pubmed.ncbi.nlm.nih.gov/20641559" title="PubMed record of this page" ref="pagearea=meta&targetsite=entrez&targetcat=link&targettype=pubmed">20641559</a></span></div><div style="margin-top:2em" class="bk_noprnt"><a class="bk_cntns" href="/books/n/micad/">Contents</a><div class="pagination bk_noprnt"><a class="active page_link prev" href="/books/n/micad/A-582941-11C/" title="Previous page in this title">< Prev</a><a class="active page_link next" href="/books/n/micad/TEIMD-11C/" title="Next page in this title">Next ></a></div></div></div></div>
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<div xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"></div><div class="portlet"><div class="portlet_head"><div class="portlet_title"><h3><span>Views</span></h3></div><a name="Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="PDF_download" id="Shutter"></a></div><div class="portlet_content"><ul xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="simple-list"><li><a href="/books/NBK23358/?report=reader">PubReader</a></li><li><a href="/books/NBK23358/?report=printable">Print View</a></li><li><a data-jig="ncbidialog" href="#_ncbi_dlg_citbx_NBK23358" data-jigconfig="width:400,modal:true">Cite this Page</a><div id="_ncbi_dlg_citbx_NBK23358" style="display:none" title="Cite this Page"><div class="bk_tt">Cheng KT. 2-[11C]Methyl-6-(2-phenylethynyl)pyridine. 2007 Nov 15 [Updated 2008 Feb 4]. In: Molecular Imaging and Contrast Agent Database (MICAD) [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2004-2013. <span class="bk_cite_avail"></span></div></div></li><li><a href="/books/NBK23358/pdf/Bookshelf_NBK23358.pdf">PDF version of this page</a> (130K)</li><li><a href="/books/n/micad/toc/bin/micad.csv">MICAD summary (CSV file)</a></li></ul></div></div><div class="portlet"><div class="portlet_head"><div class="portlet_title"><h3><span>In this page</span></h3></div><a name="Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="page-toc" id="Shutter"></a></div><div class="portlet_content"><ul xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="simple-list"><li><a href="#MPEP11C.Background" ref="log$=inpage&link_id=inpage">Background</a></li><li><a href="#MPEP11C.Synthesis" ref="log$=inpage&link_id=inpage">Synthesis</a></li><li><a href="#MPEP11C.In_Vitro_Studies_Tes" ref="log$=inpage&link_id=inpage"><i>In Vitro</i> Studies: Testing in Cells and Tissues</a></li><li><a href="#MPEP11C.Animal_Studies" ref="log$=inpage&link_id=inpage">Animal Studies</a></li><li><a href="#MPEP11C.Human_Studies" ref="log$=inpage&link_id=inpage">Human Studies</a></li><li><a href="#MPEP11C.NIH_Support" ref="log$=inpage&link_id=inpage">NIH Support</a></li><li><a href="#MPEP11C.references" ref="log$=inpage&link_id=inpage">References</a></li></ul></div></div><div class="portlet"><div class="portlet_head"><div class="portlet_title"><h3><span>Search MICAD</span></h3></div><a name="Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="source-application" id="Shutter"></a></div><div class="portlet_content"><form xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" name="frmSearch" method="get" action="/books/NBK5330/" id="frmSearch"><script type="text/javascript" src="/corehtml/pmc//js/bookshelf/micad.js">/**/</script><label class="offscreen_noflow" for="txtfield">Search term</label><input id="txtfield" type="text" name="f1_term" size="22" onKeyPress="KeyPress('micad',event,'/books/NBK5330/','')" /><button name="f1_search" type="submit">Go</button><button onclick="this.form.reset();" type="reset">Clear</button><p><b>Limit my Search:</b></p><div class="clearfix"><label for="detection">Method of detection:</label><div class="right"><select name="detection" id="detection" style="width:200px"><option value="" selected="selected">Any</option><option value="(MRI OR "Magnetic resonance imaging" OR MRS)">MRI</option><option value="Multimodal">Multimodal imaging</option><option value="Optical">Optical imaging</option><option value="PET">PET</option><option value="Photoacoustic">Photoacoustic imaging</option><option value="(SPECT OR planar)">SPECT</option><option value="Ultrasound">Ultrasound</option><option value="(x-ray OR ct)">X-ray, CT</option></select></div></div><div class="clearfix"><label for="signal">Source of signal/contrast:</label><div class="right"><select name="signal" id="signal" style="width:200px"><option value="" selected="selected">Any</option><optgroup label="MRI agents"><option value="(Copper OR Cu)">Copper</option><option value="(Europium OR Eu3+)">Europium</option><option value="(Fluorine OR 19F)">Fluorine</option><option value="(Gadolinium OR Gd3+)">Gadolinium</option><option value=""Hyperpolarized 13C"">Hyperpolarized 13C</option><option value=""Iron oxide"">Iron oxide</option><option value=""Nitroxide radicals"">Nitroxide radicals</option><option value="(Oxygen OR 17O)">Oxygen</option><option value="Thulium">Thulium</option></optgroup><optgroup label="Multimodal agents"><option value="((Gadolinium OR Gd3+) AND Optical)">Gadolinium and optical</option><option value="((Gadolinium OR Gd3+) AND (Gold OR Au))">Gadolinium and Gold</option><option value="("Iron oxide" AND (64Cu OR 124I OR 111In))">Iron oxide and
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radionuclides</option><option value="("Iron oxide" AND Optical)">Gadolinium and optical</option><option value="(Optical AND (64Cu OR 111In OR 177Lu))">Optical and
|
||
radionuclides</option><option value="(Perfluorocarbon AND (Europium OR Eu3+))">Perfluorocarbon and
|
||
europium</option><option value="(166Ho OR 67Ga OR 68Ga OR 123I OR 124I OR 125I)">Radionuclides</option></optgroup><optgroup label="Optical agents"><option value="("Fluorescent dyes" OR protein)">Fluorescent dyes or proteins</option><option value=""Luminescent agents"">Luminescent agents</option><option value="(Metals OR Metal OR Gold OR Au)">Metals (Au)</option><option value="Nanotubes">Nanotubes</option><option value=""Quantum dots"">Quantum dots</option></optgroup><optgroup label="PET radionuclides"><option value="("Arsenic 74" OR 74As)">Arsenic-74</option><option value="("Bromine 76" OR 76Br)">Bromine-76</option><option value="("Carbon 11" OR 11C)">Carbon-11</option><option value="(Copper-60 OR Copper-61 OR Copper-62 OR Copper-64 OR 60Cu OR 61Cu OR 62Cu OR 64Cu)">Copper-60, 61, 62, 64</option><option value="("Fluorine 18" OR 18F)">Fluorine-18</option><option value="(Gallium-68 OR 68Ga)">Gallium-68</option><option value="("Iodine 124" OR 124I)">Iodine-124</option><option value="("Nitrogen 13" OR 13N)">Nitrogen-13</option><option value="("Yttrium 86" OR 86Y)">Yttrium-86</option><option value="("Zirconium 89" OR 89Zr)">Zirconium-89</option></optgroup><optgroup label="Photoacoustic agents"><option value="(Gold OR Au)">Gold</option><option value="("Indocyanine green" OR ICG)">Indocyanine green</option></optgroup><optgroup label="SPECT radionuclides"><option value="(Gallium-67 OR 67Ga)">Gallium-67</option><option value="("Indium 111" OR 111In)">Indium-111</option><option value="("Iodine 123" OR "Iodine 125" OR "Iodine 131" OR 123I OR 125I OR 131I)">Iodine-123, 125, 131</option><option value="("Lutetium 177" OR 177Lu)">Lutetium-177</option><option value="(Rhenium OR 186Re OR 188Re)">Rhenium</option><option value="("Technetium 99m" OR 99mTc)">Technetium-99m</option><option value="("Tellurium 125m" OR 125mTe)">Tellurium-125m</option></optgroup><optgroup label="Ultrasound agents"><option value="Microbubbles">Microbubbles</option><option value="Nanobubbles">Nanobubbles</option></optgroup><optgroup label="X-ray and CT agents"><option value="(Bismuth OR Bi)">Bismuth</option><option value="(Gold OR Au)">Gold</option><option value="Iodine">Iodine</option></optgroup></select></div></div><div class="clearfix"><label for="agent">Agent Category:</label><div class="right"><select name="agent" id="agent" style="width:200px"><option value="" selected="selected">Any</option><option value="(antibody OR trastuzumab OR immunoglobulin)">Antibodies</option><option value="(bacteria OR bacteriophage OR coli)">Bacteria</option><option value="cell">Cells</option><option value="(compound OR "amino acid" OR "folic acid" OR "cage molecule" OR carbohydrate OR copolymers OR polymer OR "small molecule" OR macromolecule OR triiodobenzoate OR estradiol OR glycosaminoglycan)">Compounds</option><option value="ligand">Ligands</option><option value="(lipid OR liposome OR liposomes">Lipids</option><option value="metal">Metal</option><option value="(nanoparticle OR nanoparticles OR nanotubes OR "iron oxide")">Nanoparticles</option><option value="(siRNA OR "nucleic acid" OR oligonucleotide)">Nucleic acids</option><option value="peptide">Peptides</option><option value="polyeptide">Polyeptides</option><option value="(protein OR albumin OR chemokin OR immunoprotein OR luciferase OR albumin)">Proteins</option><option value="(virus OR adenovirus)">Viruses</option></select></div></div><div class="clearfix"><label for="target">Target Category:</label><div class="right"><select name="target" id="target" style="width:200px"><option value="" selected="selected">Any</option><option value="acceptor">Acceptors</option><option value=""adhesion molecule"">Adhesion molecules</option><option value="(antigen OR antibody-antigen)">Antigens</option><option value="(enzyme OR enzymes OR enzyme-substrate)">Enzymes</option><option value="(lipids OR lipophilic cation)">Lipids</option><option value="(receptor OR receptors OR receptor-ligand OR receptor-antibody OR antibody-receptor)">Receptors</option><option value="transporter">Transporters</option><option value="non-targeted">Non-targeted</option><option value=""nucleic acid"">Nucleic acids</option><option value="(non-targeted OR "unknown binding site")">Others</option></select></div></div><div><input id="__micad_btn_1" type="radio" name="stage" value="vitro" /><label for="__micad_btn_1"><i>In vitro</i></label><input id="__micad_btn_2" type="radio" name="stage" value="rodents" /><label for="__micad_btn_2">Rodents</label><input id="__micad_btn_3" type="radio" name="stage" value="mammals" /><label for="__micad_btn_3">Non-primate non-rodent mammals</label><br /><input id="__micad_btn_4" type="radio" name="stage" value="primates" /><label for="__micad_btn_4">Non-human primates</label><input id="__micad_btn_5" type="radio" name="stage" value="humans" /><label for="__micad_btn_5">Humans</label><input id="__micad_btn_6" type="radio" name="stage" value="any" checked="checked" /><label for="__micad_btn_6">Any</label></div></form><form xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" name="frmGo" method="get" action="javascript:alert('frmGo:_@action_was_not_set')" id="frmGo"><input name="term" value="." type="hidden" /></form></div></div><div class="portlet"><div class="portlet_head"><div class="portlet_title"><h3><span>Related information</span></h3></div><a name="Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="discovery_db_links" id="Shutter"></a></div><div class="portlet_content"><ul><li class="brieflinkpopper"><a class="brieflinkpopperctrl" href="/books/?Db=pcsubstance&DbFrom=books&Cmd=Link&LinkName=books_pcsubstance&IdsFromResult=1505246" ref="log$=recordlinks">PubChem Substance</a><div class="brieflinkpop offscreen_noflow">Related PubChem Substances</div></li><li class="brieflinkpopper"><a class="brieflinkpopperctrl" href="/books/?Db=pubmed&DbFrom=books&Cmd=Link&LinkName=books_pubmed_refs&IdsFromResult=1505246" ref="log$=recordlinks">PubMed</a><div class="brieflinkpop offscreen_noflow">Links to PubMed</div></li></ul></div></div><div class="portlet"><div class="portlet_head"><div class="portlet_title"><h3><span>Similar articles in PubMed</span></h3></div><a name="Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="PBooksDiscovery_RA" id="Shutter"></a></div><div class="portlet_content"><ul><li class="brieflinkpopper two_line"><a class="brieflinkpopperctrl" href="/pubmed/20641751" ref="ordinalpos=1&linkpos=1&log$=relatedreviews&logdbfrom=pubmed"><span xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="invert">Review</span> 2-(2-(3-[(11)C]Methoxyphenyl)ethynyl)pyridine.</a><span class="source">[Molecular Imaging and Contrast...]</span><div class="brieflinkpop offscreen_noflow"><span xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="invert">Review</span> 2-(2-(3-[(11)C]Methoxyphenyl)ethynyl)pyridine.<div class="brieflinkpopdesc"><em xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="author">Cheng KT. </em><em xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="cit">Molecular Imaging and Contrast Agent Database (MICAD). 2004</em></div></div></li><li class="brieflinkpopper two_line"><a class="brieflinkpopperctrl" href="/pubmed/20641867" ref="ordinalpos=1&linkpos=2&log$=relatedreviews&logdbfrom=pubmed"><span xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="invert">Review</span> 2-(2-(5-[(11)C]Methoxypyridin-3-yl)ethynyl)pyridine.</a><span class="source">[Molecular Imaging and Contrast...]</span><div class="brieflinkpop offscreen_noflow"><span xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="invert">Review</span> 2-(2-(5-[(11)C]Methoxypyridin-3-yl)ethynyl)pyridine.<div class="brieflinkpopdesc"><em xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="author">Cheng KT. </em><em xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="cit">Molecular Imaging and Contrast Agent Database (MICAD). 2004</em></div></div></li><li class="brieflinkpopper two_line"><a class="brieflinkpopperctrl" href="/pubmed/20641882" ref="ordinalpos=1&linkpos=3&log$=relatedreviews&logdbfrom=pubmed"><span xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="invert">Review</span> 3-(6-Methyl-pyridin-2-ylethynyl)-cyclohex-2-enone-O-(11)C-methyl-oxime.</a><span class="source">[Molecular Imaging and Contrast...]</span><div class="brieflinkpop offscreen_noflow"><span xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="invert">Review</span> 3-(6-Methyl-pyridin-2-ylethynyl)-cyclohex-2-enone-O-(11)C-methyl-oxime.<div class="brieflinkpopdesc"><em xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="author">Cheng KT. </em><em xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="cit">Molecular Imaging and Contrast Agent Database (MICAD). 2004</em></div></div></li><li class="brieflinkpopper two_line"><a class="brieflinkpopperctrl" href="/pubmed/20641405" ref="ordinalpos=1&linkpos=4&log$=relatedreviews&logdbfrom=pubmed"><span xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="invert">Review</span> [(18)F]3-Fluoro-5-[(pyridin-3-yl)ethynyl]benzonitrile.</a><span class="source">[Molecular Imaging and Contrast...]</span><div class="brieflinkpop offscreen_noflow"><span xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="invert">Review</span> [(18)F]3-Fluoro-5-[(pyridin-3-yl)ethynyl]benzonitrile.<div class="brieflinkpopdesc"><em xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="author">Cheng KT. </em><em xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="cit">Molecular Imaging and Contrast Agent Database (MICAD). 2004</em></div></div></li><li class="brieflinkpopper two_line"><a class="brieflinkpopperctrl" href="/pubmed/20641339" ref="ordinalpos=1&linkpos=5&log$=relatedreviews&logdbfrom=pubmed"><span xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="invert">Review</span> [(18)F]3-Fluoro-5-[(2-methyl-1,3-thiazol-4-yl)ethynyl]benzonitrile.</a><span class="source">[Molecular Imaging and Contrast...]</span><div class="brieflinkpop offscreen_noflow"><span xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="invert">Review</span> [(18)F]3-Fluoro-5-[(2-methyl-1,3-thiazol-4-yl)ethynyl]benzonitrile.<div class="brieflinkpopdesc"><em xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="author">The MICAD Research Team. </em><em xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="cit">Molecular Imaging and Contrast Agent Database (MICAD). 2004</em></div></div></li></ul><a class="seemore" href="/sites/entrez?db=pubmed&cmd=link&linkname=pubmed_pubmed_reviews&uid=20641559" ref="ordinalpos=1&log$=relatedreviews_seeall&logdbfrom=pubmed">See reviews...</a><a class="seemore" 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href="/portal/utils/pageresolver.fcgi?recordid=67d644c484f3725e59a50e1f">2-[11C]Methyl-6-(2-phenylethynyl)pyridine - Molecular Imaging and Contrast Agent...</a><div class="ralinkpop offscreen_noflow">2-[11C]Methyl-6-(2-phenylethynyl)pyridine - Molecular Imaging and Contrast Agent Database (MICAD)<div class="brieflinkpopdesc"></div></div><div class="tertiary"></div></li><li class="ra_rcd ralinkpopper two_line"><a class="htb ralinkpopperctrl" ref="log$=activity&linkpos=2" href="/portal/utils/pageresolver.fcgi?recordid=67d644c267c23b31e02b05d8">2-[11C]Methyl-5-[6-phenylpyridazine-3-yl]octahydropyrrolo[3,4-c]pyrrole - Molecu...</a><div class="ralinkpop offscreen_noflow">2-[11C]Methyl-5-[6-phenylpyridazine-3-yl]octahydropyrrolo[3,4-c]pyrrole - Molecular Imaging and Contrast Agent Database (MICAD)<div class="brieflinkpopdesc"></div></div><div class="tertiary"></div></li><li class="ra_rcd ralinkpopper two_line"><a class="htb ralinkpopperctrl" ref="log$=activity&linkpos=3" href="/portal/utils/pageresolver.fcgi?recordid=67d644c167c23b31e02b00b8">2-(6-[11C]Methyl-3,6-diazabicyclo[3.2.0]heptan-3-yl)-7-(6-methyl-3,6-diazabicycl...</a><div class="ralinkpop offscreen_noflow">2-(6-[11C]Methyl-3,6-diazabicyclo[3.2.0]heptan-3-yl)-7-(6-methyl-3,6-diazabicyclo[3.2.0]heptan-3-yl)-9H-fluoren-9-one - Molecular Imaging and Contrast Agent Database (MICAD)<div class="brieflinkpopdesc"></div></div><div class="tertiary"></div></li><li class="ra_rcd ralinkpopper two_line"><a class="htb ralinkpopperctrl" ref="log$=activity&linkpos=4" href="/portal/utils/pageresolver.fcgi?recordid=67d644c02f30673f7b6f9218">2-(5-[11C]Methyl-hexahydro-pyrrolo[3,4-c]pyrrol-2-yl)-xanthene-9-one - Molecular...</a><div class="ralinkpop offscreen_noflow">2-(5-[11C]Methyl-hexahydro-pyrrolo[3,4-c]pyrrol-2-yl)-xanthene-9-one - Molecular Imaging and Contrast Agent Database (MICAD)<div class="brieflinkpopdesc"></div></div><div class="tertiary"></div></li><li class="ra_rcd ralinkpopper two_line"><a 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