174 lines
49 KiB
Text
174 lines
49 KiB
Text
<!DOCTYPE html>
|
|
<html xmlns="http://www.w3.org/1999/xhtml" xml:lang="en" class="no-js no-jr">
|
|
<head>
|
|
<!-- For pinger, set start time and add meta elements. -->
|
|
<script type="text/javascript">var ncbi_startTime = new Date();</script>
|
|
|
|
<!-- Logger begin -->
|
|
<meta name="ncbi_db" content="books">
|
|
<meta name="ncbi_pdid" content="book-part">
|
|
<meta name="ncbi_acc" content="NBK23640">
|
|
<meta name="ncbi_domain" content="micad">
|
|
<meta name="ncbi_report" content="reader">
|
|
<meta name="ncbi_type" content="fulltext">
|
|
<meta name="ncbi_objectid" content="">
|
|
<meta name="ncbi_pcid" content="/NBK23640/?report=reader">
|
|
<meta name="ncbi_pagename" content="64Cu-DOTA-[Pro1,Tyr4]-Bombesin[1-14] - Molecular Imaging and Contrast Agent Database (MICAD) - NCBI Bookshelf">
|
|
<meta name="ncbi_bookparttype" content="chapter">
|
|
<meta name="ncbi_app" content="bookshelf">
|
|
<!-- Logger end -->
|
|
|
|
<!--component id="Page" label="meta"/-->
|
|
<script type="text/javascript" src="/corehtml/pmc/jatsreader/ptpmc_3.22/js/jr.boots.min.js"> </script><title>64Cu-DOTA-[Pro1,Tyr4]-Bombesin[1-14] - Molecular Imaging and Contrast Agent Database (MICAD) - NCBI Bookshelf</title>
|
|
<meta charset="utf-8">
|
|
<meta name="apple-mobile-web-app-capable" content="no">
|
|
<meta name="viewport" content="initial-scale=1,minimum-scale=1,maximum-scale=1,user-scalable=no">
|
|
<meta name="jr-col-layout" content="auto">
|
|
<meta name="jr-prev-unit" content="/books/n/micad/Cu64-DTPA-ProT/?report=reader">
|
|
<meta name="jr-next-unit" content="/books/n/micad/TrastFv-FcDM64Cu/?report=reader">
|
|
<meta name="bk-toc-url" content="/books/n/micad/?report=toc">
|
|
<meta name="robots" content="INDEX,FOLLOW,NOARCHIVE">
|
|
<meta name="citation_inbook_title" content="Molecular Imaging and Contrast Agent Database (MICAD) [Internet]">
|
|
<meta name="citation_title" content="64Cu-DOTA-[Pro1,Tyr4]-Bombesin[1-14]">
|
|
<meta name="citation_publisher" content="National Center for Biotechnology Information (US)">
|
|
<meta name="citation_date" content="2008/01/08">
|
|
<meta name="citation_author" content="Kenneth T. Cheng">
|
|
<meta name="citation_author" content="Jason S. Lewis">
|
|
<meta name="citation_author" content="Gráinne B. Biddlecombe">
|
|
<meta name="citation_pmid" content="20641835">
|
|
<meta name="citation_fulltext_html_url" content="https://www.ncbi.nlm.nih.gov/books/NBK23640/">
|
|
<link rel="schema.DC" href="http://purl.org/DC/elements/1.0/">
|
|
<meta name="DC.Title" content="64Cu-DOTA-[Pro1,Tyr4]-Bombesin[1-14]">
|
|
<meta name="DC.Type" content="Text">
|
|
<meta name="DC.Publisher" content="National Center for Biotechnology Information (US)">
|
|
<meta name="DC.Contributor" content="Kenneth T. Cheng">
|
|
<meta name="DC.Contributor" content="Jason S. Lewis">
|
|
<meta name="DC.Contributor" content="Gráinne B. Biddlecombe">
|
|
<meta name="DC.Date" content="2008/01/08">
|
|
<meta name="DC.Identifier" content="https://www.ncbi.nlm.nih.gov/books/NBK23640/">
|
|
<meta name="description" content="64Cu-DOTA-[Pro1,Tyr4]-Bombesin[1-14] (64Cu-MP2346) is a peptide analog of human gastrin-releasing peptide (GRP) conjugated with 64Cu, and it was developed for positron emission tomography (PET) imaging of tumors with overexpressed GRP receptors (GRP-R) (1). 64Cu is a positron emitter with a 19.3% abundance and a physical half-life (t½) of 12.7 h.">
|
|
<meta name="og:title" content="64Cu-DOTA-[Pro1,Tyr4]-Bombesin[1-14]">
|
|
<meta name="og:type" content="book">
|
|
<meta name="og:description" content="64Cu-DOTA-[Pro1,Tyr4]-Bombesin[1-14] (64Cu-MP2346) is a peptide analog of human gastrin-releasing peptide (GRP) conjugated with 64Cu, and it was developed for positron emission tomography (PET) imaging of tumors with overexpressed GRP receptors (GRP-R) (1). 64Cu is a positron emitter with a 19.3% abundance and a physical half-life (t½) of 12.7 h.">
|
|
<meta name="og:url" content="https://www.ncbi.nlm.nih.gov/books/NBK23640/">
|
|
<meta name="og:site_name" content="NCBI Bookshelf">
|
|
<meta name="og:image" content="https://www.ncbi.nlm.nih.gov/corehtml/pmc/pmcgifs/bookshelf/thumbs/th-micad-lrg.png">
|
|
<meta name="twitter:card" content="summary">
|
|
<meta name="twitter:site" content="@ncbibooks">
|
|
<meta name="bk-non-canon-loc" content="/books/n/micad/MP2346Cu64/?report=reader">
|
|
<link rel="canonical" href="https://www.ncbi.nlm.nih.gov/books/NBK23640/">
|
|
<link href="https://fonts.googleapis.com/css?family=Archivo+Narrow:400,700,400italic,700italic&subset=latin" rel="stylesheet" type="text/css">
|
|
<link rel="stylesheet" href="/corehtml/pmc/jatsreader/ptpmc_3.22/css/libs.min.css">
|
|
<link rel="stylesheet" href="/corehtml/pmc/jatsreader/ptpmc_3.22/css/jr.min.css">
|
|
<meta name="format-detection" content="telephone=no">
|
|
<link rel="stylesheet" href="/corehtml/pmc/css/bookshelf/2.26/css/books.min.css" type="text/css">
|
|
<link rel="stylesheet" href="/corehtml/pmc/css/bookshelf/2.26/css//books_print.min.css" type="text/css" media="print">
|
|
<link rel="stylesheet" href="/corehtml/pmc/css/bookshelf/2.26/css/books_reader.min.css" type="text/css">
|
|
<style type="text/css">p a.figpopup{display:inline !important} .bk_tt {font-family: monospace} .first-line-outdent .bk_ref {display: inline} .body-content h2, .body-content .h2 {border-bottom: 1px solid #97B0C8} .body-content h2.inline {border-bottom: none} a.page-toc-label , .jig-ncbismoothscroll a {text-decoration:none;border:0 !important} .temp-labeled-list .graphic {display:inline-block !important} .temp-labeled-list img{width:100%}</style>
|
|
|
|
<link rel="shortcut icon" href="//www.ncbi.nlm.nih.gov/favicon.ico">
|
|
<meta name="ncbi_phid" content="CE8C0AD67D6461910000000000610055.m_5">
|
|
<meta name='referrer' content='origin-when-cross-origin'/><link type="text/css" rel="stylesheet" href="//static.pubmed.gov/portal/portal3rc.fcgi/4216699/css/3852956/3849091.css"></head>
|
|
<body>
|
|
<!-- Book content! -->
|
|
|
|
|
|
<div id="jr" data-jr-path="/corehtml/pmc/jatsreader/ptpmc_3.22/"><div class="jr-unsupported"><table class="modal"><tr><td><span class="attn inline-block"></span><br />Your browser does not support the NLM PubReader view.<br />Go to <a href="/pmc/about/pr-browsers/">this page</a> to see a list of supported browsers<br />or return to the <br /><a href="/books/NBK23640/?report=classic">regular view</a>.</td></tr></table></div><div id="jr-ui" class="hidden"><nav id="jr-head"><div class="flexh tb"><div id="jr-tb1"><a id="jr-links-sw" class="hidden" title="Links"><svg xmlns="http://www.w3.org/2000/svg" version="1.1" x="0px" y="0px" viewBox="0 0 70.6 85.3" style="enable-background:new 0 0 70.6 85.3;vertical-align:middle" xml:space="preserve" width="24" height="24">
|
|
<style type="text/css">.st0{fill:#939598;}</style>
|
|
<g>
|
|
<path class="st0" d="M36,0C12.8,2.2-22.4,14.6,19.6,32.5C40.7,41.4-30.6,14,35.9,9.8"></path>
|
|
<path class="st0" d="M34.5,85.3c23.2-2.2,58.4-14.6,16.4-32.5c-21.1-8.9,50.2,18.5-16.3,22.7"></path>
|
|
<path class="st0" d="M34.7,37.1c66.5-4.2-4.8-31.6,16.3-22.7c42.1,17.9,6.9,30.3-16.4,32.5h1.7c-66.2,4.4,4.8,31.6-16.3,22.7 c-42.1-17.9-6.9-30.3,16.4-32.5"></path>
|
|
</g>
|
|
</svg> Books</a></div><div class="jr-rhead f1 flexh"><div class="head"><a href="/books/n/micad/Cu64-DTPA-ProT/?report=reader"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 100 100" preserveAspectRatio="none"><path d="M75,30 c-80,60 -80,0 0,60 c-30,-60 -30,0 0,-60"></path><text x="20" y="28" textLength="60" style="font-size:25px">Prev</text></svg></a></div><div class="body"><div class="t">64Cu-DOTA-[Pro1,Tyr4]-Bombesin[1-14]</div><div class="j">Molecular Imaging and Contrast Agent Database (MICAD) [Internet]</div></div><div class="tail"><a href="/books/n/micad/TrastFv-FcDM64Cu/?report=reader"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 100 100" preserveAspectRatio="none"><path d="M25,30c80,60 80,0 0,60 c30,-60 30,0 0,-60"></path><text x="20" y="28" textLength="60" style="font-size:25px">Next</text></svg></a></div></div><div id="jr-tb2"><a id="jr-bkhelp-sw" class="btn wsprkl hidden" title="Help with NLM PubReader">?</a><a id="jr-help-sw" class="btn wsprkl hidden" title="Settings and typography in NLM PubReader"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 512 512" preserveAspectRatio="none"><path d="M462,283.742v-55.485l-29.981-10.662c-11.431-4.065-20.628-12.794-25.274-24.001 c-0.002-0.004-0.004-0.009-0.006-0.013c-4.659-11.235-4.333-23.918,0.889-34.903l13.653-28.724l-39.234-39.234l-28.72,13.652 c-10.979,5.219-23.68,5.546-34.908,0.889c-0.005-0.002-0.01-0.003-0.014-0.005c-11.215-4.65-19.933-13.834-24-25.273L283.741,50 h-55.484l-10.662,29.981c-4.065,11.431-12.794,20.627-24.001,25.274c-0.005,0.002-0.009,0.004-0.014,0.005 c-11.235,4.66-23.919,4.333-34.905-0.889l-28.723-13.653l-39.234,39.234l13.653,28.721c5.219,10.979,5.545,23.681,0.889,34.91 c-0.002,0.004-0.004,0.009-0.006,0.013c-4.649,11.214-13.834,19.931-25.271,23.998L50,228.257v55.485l29.98,10.661 c11.431,4.065,20.627,12.794,25.274,24c0.002,0.005,0.003,0.01,0.005,0.014c4.66,11.236,4.334,23.921-0.888,34.906l-13.654,28.723 l39.234,39.234l28.721-13.652c10.979-5.219,23.681-5.546,34.909-0.889c0.005,0.002,0.01,0.004,0.014,0.006 c11.214,4.649,19.93,13.833,23.998,25.271L228.257,462h55.484l10.595-29.79c4.103-11.538,12.908-20.824,24.216-25.525 c0.005-0.002,0.009-0.004,0.014-0.006c11.127-4.628,23.694-4.311,34.578,0.863l28.902,13.738l39.234-39.234l-13.66-28.737 c-5.214-10.969-5.539-23.659-0.886-34.877c0.002-0.005,0.004-0.009,0.006-0.014c4.654-11.225,13.848-19.949,25.297-24.021 L462,283.742z M256,331.546c-41.724,0-75.548-33.823-75.548-75.546s33.824-75.547,75.548-75.547 c41.723,0,75.546,33.824,75.546,75.547S297.723,331.546,256,331.546z"></path></svg></a><a id="jr-fip-sw" class="btn wsprkl hidden" title="Find"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 550 600" preserveAspectRatio="none"><path fill="none" stroke="#000" stroke-width="36" stroke-linecap="round" style="fill:#FFF" d="m320,350a153,153 0 1,0-2,2l170,170m-91-117 110,110-26,26-110-110"></path></svg></a><a id="jr-rtoc-sw" class="btn wsprkl hidden" title="Table of Contents"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 100 100" preserveAspectRatio="none"><path d="M20,20h10v8H20V20zM36,20h44v8H36V20zM20,37.33h10v8H20V37.33zM36,37.33h44v8H36V37.33zM20,54.66h10v8H20V54.66zM36,54.66h44v8H36V54.66zM20,72h10v8 H20V72zM36,72h44v8H36V72z"></path></svg></a></div></div></nav><nav id="jr-dash" class="noselect"><nav id="jr-dash" class="noselect"><div id="jr-pi" class="hidden"><a id="jr-pi-prev" class="hidden" title="Previous page"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 100 100" preserveAspectRatio="none"><path d="M75,30 c-80,60 -80,0 0,60 c-30,-60 -30,0 0,-60"></path><text x="20" y="28" textLength="60" style="font-size:25px">Prev</text></svg></a><div class="pginfo">Page <i class="jr-pg-pn">0</i> of <i class="jr-pg-lp">0</i></div><a id="jr-pi-next" class="hidden" title="Next page"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 100 100" preserveAspectRatio="none"><path d="M25,30c80,60 80,0 0,60 c30,-60 30,0 0,-60"></path><text x="20" y="28" textLength="60" style="font-size:25px">Next</text></svg></a></div><div id="jr-is-tb"><a id="jr-is-sw" class="btn wsprkl hidden" title="Switch between Figures/Tables strip and Progress bar"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 100 100" preserveAspectRatio="none"><rect x="10" y="40" width="20" height="20"></rect><rect x="40" y="40" width="20" height="20"></rect><rect x="70" y="40" width="20" height="20"></rect></svg></a></div><nav id="jr-istrip" class="istrip hidden"><a id="jr-is-prev" href="#" class="hidden" title="Previous"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 100 100" preserveAspectRatio="none"><path d="M80,40 60,65 80,90 70,90 50,65 70,40z M50,40 30,65 50,90 40,90 20,65 40,40z"></path><text x="35" y="25" textLength="60" style="font-size:25px">Prev</text></svg></a><a id="jr-is-next" href="#" class="hidden" title="Next"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 100 100" preserveAspectRatio="none"><path d="M20,40 40,65 20,90 30,90 50,65 30,40z M50,40 70,65 50,90 60,90 80,65 60,40z"></path><text x="15" y="25" textLength="60" style="font-size:25px">Next</text></svg></a></nav><nav id="jr-progress"></nav></nav></nav><aside id="jr-links-p" class="hidden flexv"><div class="tb sk-htbar flexh"><div><a class="jr-p-close btn wsprkl">Done</a></div><div class="title-text f1">NCBI Bookshelf</div></div><div class="cnt lol f1"><a href="/books/">Home</a><a href="/books/browse/">Browse All Titles</a><a class="btn share" target="_blank" rel="noopener noreferrer" href="https://www.facebook.com/sharer/sharer.php?u=https://www.ncbi.nlm.nih.gov/books/NBK23640/"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 33 33" style="vertical-align:middle" width="24" height="24" preserveAspectRatio="none"><g><path d="M 17.996,32L 12,32 L 12,16 l-4,0 l0-5.514 l 4-0.002l-0.006-3.248C 11.993,2.737, 13.213,0, 18.512,0l 4.412,0 l0,5.515 l-2.757,0 c-2.063,0-2.163,0.77-2.163,2.209l-0.008,2.76l 4.959,0 l-0.585,5.514L 18,16L 17.996,32z"></path></g></svg> Share on Facebook</a><a class="btn share" target="_blank" rel="noopener noreferrer" href="https://twitter.com/intent/tweet?url=https://www.ncbi.nlm.nih.gov/books/NBK23640/&text=64Cu-DOTA-%5BPro1%2CTyr4%5D-Bombesin%5B1-14%5D"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 33 33" style="vertical-align:middle" width="24" height="24"><g><path d="M 32,6.076c-1.177,0.522-2.443,0.875-3.771,1.034c 1.355-0.813, 2.396-2.099, 2.887-3.632 c-1.269,0.752-2.674,1.299-4.169,1.593c-1.198-1.276-2.904-2.073-4.792-2.073c-3.626,0-6.565,2.939-6.565,6.565 c0,0.515, 0.058,1.016, 0.17,1.496c-5.456-0.274-10.294-2.888-13.532-6.86c-0.565,0.97-0.889,2.097-0.889,3.301 c0,2.278, 1.159,4.287, 2.921,5.465c-1.076-0.034-2.088-0.329-2.974-0.821c-0.001,0.027-0.001,0.055-0.001,0.083 c0,3.181, 2.263,5.834, 5.266,6.438c-0.551,0.15-1.131,0.23-1.73,0.23c-0.423,0-0.834-0.041-1.235-0.118 c 0.836,2.608, 3.26,4.506, 6.133,4.559c-2.247,1.761-5.078,2.81-8.154,2.81c-0.53,0-1.052-0.031-1.566-0.092 c 2.905,1.863, 6.356,2.95, 10.064,2.95c 12.076,0, 18.679-10.004, 18.679-18.68c0-0.285-0.006-0.568-0.019-0.849 C 30.007,8.548, 31.12,7.392, 32,6.076z"></path></g></svg> Share on Twitter</a></div></aside><aside id="jr-rtoc-p" class="hidden flexv"><div class="tb sk-htbar flexh"><div><a class="jr-p-close btn wsprkl">Done</a></div><div class="title-text f1">Table of Content</div></div><div class="cnt lol f1"><a href="/books/n/micad/?report=reader">Title Information</a><a href="/books/n/micad/toc/?report=reader">Table of Contents Page</a></div></aside><aside id="jr-help-p" class="hidden flexv"><div class="tb sk-htbar flexh"><div><a class="jr-p-close btn wsprkl">Done</a></div><div class="title-text f1">Settings</div></div><div class="cnt f1"><div id="jr-typo-p" class="typo"><div><a class="sf btn wsprkl">A-</a><a class="lf btn wsprkl">A+</a></div><div><a class="bcol-auto btn wsprkl"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 200 100" preserveAspectRatio="none"><text x="10" y="70" style="font-size:60px;font-family: Trebuchet MS, ArialMT, Arial, sans-serif" textLength="180">AUTO</text></svg></a><a class="bcol-1 btn wsprkl"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 100 100" preserveAspectRatio="none"><path d="M15,25 85,25zM15,40 85,40zM15,55 85,55zM15,70 85,70z"></path></svg></a><a class="bcol-2 btn wsprkl"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 100 100" preserveAspectRatio="none"><path d="M5,25 45,25z M55,25 95,25zM5,40 45,40z M55,40 95,40zM5,55 45,55z M55,55 95,55zM5,70 45,70z M55,70 95,70z"></path></svg></a></div></div><div class="lol"><a class="" href="/books/NBK23640/?report=classic">Switch to classic view</a><a href="/books/NBK23640/pdf/Bookshelf_NBK23640.pdf">PDF (144K)</a><a href="/books/NBK23640/?report=printable">Print View</a></div></div></aside><aside id="jr-bkhelp-p" class="hidden flexv"><div class="tb sk-htbar flexh"><div><a class="jr-p-close btn wsprkl">Done</a></div><div class="title-text f1">Help</div></div><div class="cnt f1 lol"><a id="jr-helpobj-sw" data-path="/corehtml/pmc/jatsreader/ptpmc_3.22/" data-href="/corehtml/pmc/jatsreader/ptpmc_3.22/img/bookshelf/help.xml" href="">Help</a><a href="mailto:info@ncbi.nlm.nih.gov?subject=PubReader%20feedback%20%2F%20NBK23640%20%2F%20sid%3ACE8B5AF87C7FFCB1_0191SID%20%2F%20phid%3ACE8C0AD67D6461910000000000610055.4">Send us feedback</a><a id="jr-about-sw" data-path="/corehtml/pmc/jatsreader/ptpmc_3.22/" data-href="/corehtml/pmc/jatsreader/ptpmc_3.22/img/bookshelf/about.xml" href="">About PubReader</a></div></aside><aside id="jr-objectbox" class="thidden hidden"><div class="jr-objectbox-close wsprkl">✘</div><div class="jr-objectbox-inner cnt"><div class="jr-objectbox-drawer"></div></div></aside><nav id="jr-pm-left" class="hidden"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 40 800" preserveAspectRatio="none"><text font-stretch="ultra-condensed" x="800" y="-15" text-anchor="end" transform="rotate(90)" font-size="18" letter-spacing=".1em">Previous Page</text></svg></nav><nav id="jr-pm-right" class="hidden"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 40 800" preserveAspectRatio="none"><text font-stretch="ultra-condensed" x="800" y="-15" text-anchor="end" transform="rotate(90)" font-size="18" letter-spacing=".1em">Next Page</text></svg></nav><nav id="jr-fip" class="hidden"><nav id="jr-fip-term-p"><input type="search" placeholder="search this page" id="jr-fip-term" autocorrect="off" autocomplete="off" /><a id="jr-fip-mg" class="wsprkl btn" title="Find"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 550 600" preserveAspectRatio="none"><path fill="none" stroke="#000" stroke-width="36" stroke-linecap="round" style="fill:#FFF" d="m320,350a153,153 0 1,0-2,2l170,170m-91-117 110,110-26,26-110-110"></path></svg></a><a id="jr-fip-done" class="wsprkl btn" title="Dismiss find">✘</a></nav><nav id="jr-fip-info-p"><a id="jr-fip-prev" class="wsprkl btn" title="Jump to previuos match">◀</a><button id="jr-fip-matches">no matches yet</button><a id="jr-fip-next" class="wsprkl btn" title="Jump to next match">▶</a></nav></nav></div><div id="jr-epub-interstitial" class="hidden"></div><div id="jr-content"><article data-type="main"><div class="main-content lit-style" itemscope="itemscope" itemtype="http://schema.org/CreativeWork"><div class="meta-content fm-sec"><div class="fm-sec"><h1 id="_NBK23640_"><span class="title" itemprop="name"><sup>64</sup>Cu-DOTA-[Pro<sup>1</sup>,Tyr<sup>4</sup>]-Bombesin[1-14]</span></h1><div itemprop="alternativeHeadline" class="subtitle whole_rhythm"><sup>64</sup>Cu-MP2346</div><p class="contribs">Cheng KT, Lewis JS, Biddlecombe GB.</p><p class="fm-aai"><a href="#_NBK23640_pubdet_">Publication Details</a></p></div></div><div class="jig-ncbiinpagenav body-content whole_rhythm" data-jigconfig="allHeadingLevels: ['h2'],smoothScroll: false" itemprop="text"><div class="iconblock whole_rhythm clearfix ten_col table-wrap" id="figMP2346Cu64T1"><a href="/books/NBK23640/table/MP2346Cu64.T1/?report=objectonly" target="object" title="Table" class="img_link icnblk_img" rid-ob="figobMP2346Cu64T1"><img class="small-thumb" src="/corehtml/pmc/css/bookshelf/2.26/img/table-icon.gif" alt="Table Icon" /></a><div class="icnblk_cntnt"><h4 id="MP2346Cu64.T1"><a href="/books/NBK23640/table/MP2346Cu64.T1/?report=objectonly" target="object" rid-ob="figobMP2346Cu64T1">Table</a></h4><p class="float-caption no_bottom_margin">
|
|
|
|
<i>In vitro</i>
|
|
|
|
|
|
Rodents
|
|
</p></div></div><div id="MP2346Cu64.Background"><h2 id="_MP2346Cu64_Background_">Background</h2><p>[<a href="/sites/entrez?Db=pubmed&Cmd=DetailsSearch&Term=(86Y-Bombesin)+OR+(gastrin-releasing+peptide+probe)" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">PubMed</a>]</p><p><sup>64</sup>Cu-DOTA-[Pro<sup>1</sup>,Tyr<sup>4</sup>]-Bombesin[1-14] (<sup>64</sup>Cu-MP2346) is a peptide analog of human gastrin-releasing peptide (GRP) conjugated with <sup>64</sup>Cu, and it was developed for positron emission tomography (PET) imaging of tumors with overexpressed GRP receptors (GRP-R) (<a class="bibr" href="#MP2346Cu64.EXTYLES.1" rid="MP2346Cu64.EXTYLES.1">1</a>). <sup>64</sup>Cu is a positron emitter with a 19.3% abundance and a physical half-life (<i>t</i><sub>½</sub>) of 12.7 h.</p><p>The amphibian bombesin (BBN or BN), a peptide of 14 amino acids, is an analog of human GRP, a peptide of 27 amino acids, that binds to GRP-R with high affinity and specificity (<a class="bibr" href="#MP2346Cu64.EXTYLES.2" rid="MP2346Cu64.EXTYLES.2">2</a>, <a class="bibr" href="#MP2346Cu64.EXTYLES.3" rid="MP2346Cu64.EXTYLES.3">3</a>). Both GRP and BN share an amidated C-terminus sequence homology of seven amino acids, -Trp-Ala-Val-Gly-His-Leu-Met-NH<sub>2</sub>. BN-Like peptides have been shown to induce various biological responses in diverse tissues, including the central nervous system (CNS) and the gastrointestinal (GI) system (<a class="bibr" href="#MP2346Cu64.EXTYLES.4" rid="MP2346Cu64.EXTYLES.4">4</a>, <a class="bibr" href="#MP2346Cu64.EXTYLES.5" rid="MP2346Cu64.EXTYLES.5">5</a>). They also act as potential growth factors for both normal and neoplastic tissues. Specific BN receptors (BN-R) have been identified in CNS and GI tissues and a number of tumor cell lines. The BN-R superfamily includes at least four different subtypes, namely the GRP-R subtype (BB2), the neuromedin B receptor subtype (BB1), the BB3 subtype, and the BB4 subtype (<a class="bibr" href="#MP2346Cu64.EXTYLES.6" rid="MP2346Cu64.EXTYLES.6">6</a>). Overexpression of GRP-R in various human tumors (e.g., breast, prostate, lung, colon, ovarian, and pancreatic cancers) provides opportunities to image tumors with the use of specific molecular imaging agents designed to target the GRP-R (<a class="bibr" href="#MP2346Cu64.EXTYLES.1" rid="MP2346Cu64.EXTYLES.1">1</a>, <a class="bibr" href="#MP2346Cu64.EXTYLES.3" rid="MP2346Cu64.EXTYLES.3">3</a>, <a href="#MP2346Cu64.EXTYLES.7">7-9</a>).</p><p>There have been varying degrees of success in the current development of GRP-R–targeted radiopharmaceuticals for diagnostic or therapeutic applications (<a class="bibr" href="#MP2346Cu64.EXTYLES.9" rid="MP2346Cu64.EXTYLES.9">9</a>). Various BN analogs have been labeled with <sup>99m</sup>Tc and <sup>111</sup>In for single-photon emission computed tomography (SPECT) imaging (<a class="bibr" href="#MP2346Cu64.EXTYLES.10" rid="MP2346Cu64.EXTYLES.10">10</a>, <a class="bibr" href="#MP2346Cu64.EXTYLES.11" rid="MP2346Cu64.EXTYLES.11">11</a>). BN Analogs labeled with <sup>68</sup>Ga, <sup>18</sup>F, <sup>86</sup>Y, or <sup>64</sup>Cu have been studied for PET imaging (<a class="bibr" href="#MP2346Cu64.EXTYLES.1" rid="MP2346Cu64.EXTYLES.1">1</a>, <a class="bibr" href="#MP2346Cu64.EXTYLES.12" rid="MP2346Cu64.EXTYLES.12">12</a>, <a class="bibr" href="#MP2346Cu64.EXTYLES.13" rid="MP2346Cu64.EXTYLES.13">13</a>). Breeman et al. (<a class="bibr" href="#MP2346Cu64.EXTYLES.14" rid="MP2346Cu64.EXTYLES.14">14</a>, <a class="bibr" href="#MP2346Cu64.EXTYLES.15" rid="MP2346Cu64.EXTYLES.15">15</a>) prepared two GRP-R agonists, diethylenetriamine pentaacetic acid (DTPA)-[Pro<sup>1</sup>,Tyr<sup>4</sup>]BN[1-14] and 1,4,7,10-tetraazacyclododecane-<i>N</i>,<i>N'</i>,<i>N''</i>,<i>N'''</i>-tetraacetic acid (DOTA)-[Pro<sup>1</sup>,Tyr<sup>4</sup>]BN[1-14] (MP2346), for radiometal labeling by replacing pGlu<sup>1</sup> and Leu<sup>4</sup> in the native BN with DTPA-Pro or DOTA-Pro and with Tyr, respectively. Both MP2346 and DTPA-[Pro<sup>1</sup>,Tyr<sup>4</sup>]BN[1-14] were readily labeled with <sup>111</sup>In and appeared to be promising radioligands for SPECT imaging. For PET imaging, Biddlecombe et al. (<a class="bibr" href="#MP2346Cu64.EXTYLES.1" rid="MP2346Cu64.EXTYLES.1">1</a>) prepared and evaluated <sup>64</sup>Cu-MP2346 and <sup>86</sup>Y-MP2346. The investigators reported distinct differences in the <i>in vivo</i> pharmacokinetics and tumor uptake of these two radioligands; the authors suggested that this may be the result of their differences in peptide-to-receptor affinity, overall chemical charge, and radiometal-chelate stability.</p></div><div id="MP2346Cu64.Synthesis"><h2 id="_MP2346Cu64_Synthesis_">Synthesis</h2><p>[<a href="/sites/entrez?Db=pubmed&Cmd=DetailsSearch&Term=(86Y-Bombesin)+OR+(gastrin-releasing+peptide+probe)" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">PubMed</a>]</p><p>Biddlecombe et al. (<a class="bibr" href="#MP2346Cu64.EXTYLES.1" rid="MP2346Cu64.EXTYLES.1">1</a>) reported the synthesis of <sup>64</sup>Cu-MP2346. The [Pro<sup>1</sup>,Tyr<sup>4</sup>]BN[1-14] peptide was synthesized by the standard 9-fluorenylmethyloxycarbonyl (Fmoc) solid-phase chemistry and Rink amide resin. The DOTA conjugation procedure with [Pro<sup>1</sup>,Tyr<sup>4</sup>]BN[1-14] was not discussed. The standard method that involved the sulfosuccinimidyl ester of DOTA was used (<a class="bibr" href="#MP2346Cu64.EXTYLES.16" rid="MP2346Cu64.EXTYLES.16">16</a>). The resulting MP2346 was purified with high-performance liquid chromatography (HPLC), and the mass was confirmed by mass spectrometry. The radiolabeling involved mixing MP2346 with <sup>64</sup>Cu chloride (<sup>64</sup>CuCl<sub>2</sub>) in ammonium acetate (pH 5.5). The reaction mixture was incubated at 80ºC for 30 min. Reaction progress and purity were analyzed by analytical reverse-phase HPLC. On the basis of the HPLC analysis, the radiochemical yield and radiochemical purity were >99%. The specific activity was 36.6 MBq/μg (0.99 mCi/μg) or 72.5 GBq/μmol (1.958 Ci/μmol).</p></div><div id="MP2346Cu64.In_Vitro_Studies_Tes"><h2 id="_MP2346Cu64_In_Vitro_Studies_Tes_"><i>In Vitro</i> Studies: Testing in Cells and Tissues</h2><p>[<a href="/sites/entrez?Db=pubmed&Cmd=DetailsSearch&Term=((86Y-Bombesin)+OR+(gastrin-releasing+peptide+probe))+AND+(in+vitro)" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">PubMed</a>]</p><p>Biddlecombe et al. (<a class="bibr" href="#MP2346Cu64.EXTYLES.1" rid="MP2346Cu64.EXTYLES.1">1</a>) performed <i>in vitro</i> internalization studies (<i>n</i> = 3) of <sup>64</sup>Cu-MP2346 in human prostate adenocarcinoma PC-3 cells. The amount of specifically internalized <sup>64</sup>Cu-MP2346 was 121.83 ± 33.74 fmol/mg at 15 min after incubation and increased steadily to 512.04 ± 83.41 fmol/mg at 20 h. The amount of surface-bound radioactivity was <100 fmol/mg at all times, and the maximum internalized radioactivity was 535 fmol/mg. In comparison, the <sup>86</sup>Y-MP2346 had a maximum internalization of 1,945 fmol/mg.</p></div><div id="MP2346Cu64.Animal_Studies"><h2 id="_MP2346Cu64_Animal_Studies_">Animal Studies</h2><div id="MP2346Cu64.Rodents"><h3>Rodents</h3><p>[<a href="/sites/entrez?Db=pubmed&Cmd=DetailsSearch&Term=((86Y-Bombesin)+OR+(gastrin-releasing+peptide+probe))++AND+(mice)" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">PubMed</a>]</p><p>Biodistribution studies of <sup>64</sup>Cu-MP2346 were performed in nude mice (<i>n</i> = 5) bearing human prostate adenocarcinoma PC-3 tumors in their flanks (<a class="bibr" href="#MP2346Cu64.EXTYLES.1" rid="MP2346Cu64.EXTYLES.1">1</a>). Each mouse received 0.22–0.27 kBq (8–10 μCi) radioactivity in 8–10 ng of <sup>64</sup>Cu-MP2346 by i.v. administration. <sup>64</sup>Cu-MP2346 showed rapid clearance of radioactivity from the blood over 24 h. The tumor radioactivity levels in percentage injected dose per gram (% ID/g) were 0.793 ± 0.181 (1 h), 0.421 ± 0.214 (4 h), and 0.309 ± 0.199 (24 h). The tumor/blood ratios were 6.192 (1 h), 5.511 (4 h), and 4.487 (24 h), and the tumor/muscle ratios were 2.718 (1 h), 4.996 (4 h), and 9.056 (24 h). In comparison, the tumor radioactivity levels and tumor/organ ratios of <sup>86</sup>Y-MP2346 were significantly higher (<i>P</i> < 0.0005). At 1 h, the radioactivity levels (% ID/g) for major organs were 0.128 ± 0.0015 (blood), 0.426 ± 0.117 (lung), 1.329 ± 0.304 (liver), 6.148 ± 1.067 (kidney), 0.316 ± 0.255 (muscle), 0.160 ± 0.048 (heart), 0.885 ± 0.928 (bone), and 4.387 ± 1.090 (pancreas). At 24 h, these levels changed to 0.069 ± 0.007 (blood), 0.218 ± 0.043 (lung), 1.089 ± 0.429 (liver), 1.222 ± 0.296 (kidney), 0.034 ± 0.013 (muscle), 0.1865 ± 0.024 (heart), 0.038 ± 0.026 (bone), and 1.155 ± 0.327 (pancreas). Blocking studies with preinjection of 100 μg of [Tyr<sup>4</sup>]-BN immediately before radioligand injection were performed, and the mice were euthanized 1 h after injection. Radioactivity levels of both the tumor and GRP-R–rich pancreas decreased significantly (<i>P</i> < 0.0005) to 0.099 ± 0.134% ID/g and 0.464 ± 0.259% ID/g, respectively. Similar trends were observed in other GRP-R–rich organs.</p><p>PET imaging with computed tomography coregistration of <sup>64</sup>Cu-MP2346 was conducted in mice bearing PC-3 tumors (<i>n</i> = 3) with a dose of 4.625 MBq (0.125 mCi) in 125 ng peptide by i.v. administration (<a class="bibr" href="#MP2346Cu64.EXTYLES.1" rid="MP2346Cu64.EXTYLES.1">1</a>). The images showed that the radioactivity distribution pattern was similar to that of the biodistribution studies. The tumor was clearly visualized for 1–24 h. There was significant activity in the liver as shown by the biodistribution studies. The blocking study of mice coinjected with 100 μg [Tyr<sup>4</sup>]-BN and imaged side by side with mice that received only <sup>64</sup>Cu-MP2346 showed a significant reduction of tumor radioactivity. The measured standard uptake value of <sup>64</sup>Cu-MP2346 for the tumor at 1 h after injection decreased from ~1 (range, 0.8-1) in the study without blocking to ~0.4 (0.2–0.5) with blocking (extrapolated from Figure 4).</p></div><div id="MP2346Cu64.Other_NonPrimate_Mam"><h3>Other Non-Primate Mammals</h3><p>[<a href="/sites/entrez?Db=pubmed&Cmd=DetailsSearch&Term=((86Y-Bombesin)+OR+(gastrin-releasing+peptide+probe))+AND+(primate+NOT+human)" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">PubMed</a>]</p><p>No publication is currently available.</p></div><div id="MP2346Cu64.NonHuman_Primates"><h3>Non-Human Primates</h3><p>[<a href="/sites/entrez?Db=pubmed&Cmd=DetailsSearch&Term=((86Y-Bombesin)+OR+(gastrin-releasing+peptide+probe))+AND+(primate+NOT+human)" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">PubMed</a>]</p><p>No publication is currently available.</p></div></div><div id="MP2346Cu64.Human_Studies"><h2 id="_MP2346Cu64_Human_Studies_">Human Studies</h2><p>[<a href="/sites/entrez?Db=pubmed&Cmd=DetailsSearch&Term=((86Y-Bombesin)+OR+(gastrin-releasing+peptide+probe))+AND+(humans)" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">PubMed</a>]</p><p>No publication is currently available.</p></div><div id="MP2346Cu64.NIH_Support"><h2 id="_MP2346Cu64_NIH_Support_">NIH Support</h2><p>NCI R24 CA86307, NIH/NCI SAIRP grant R24 CA83060, NCI Cancer Center Support Grant 1 P30 CA91842.</p></div><div id="MP2346Cu64.references"><h2 id="_MP2346Cu64_references_">References</h2><dl class="temp-labeled-list"><dl class="bkr_refwrap"><dt>1.</dt><dd><div class="bk_ref" id="MP2346Cu64.EXTYLES.1">Biddlecombe G.B. , Rogers B.E. , de Visser M. , Parry J.J. , de Jong M. , Erion J.L. , Lewis J.S. Molecular imaging of gastrin-releasing peptide receptor-positive tumors in mice using 64Cu- and 86Y-DOTA-(Pro1,Tyr4)-bombesin(1-14). <span><span class="ref-journal">Bioconjug Chem. </span>2007;<span class="ref-vol">
|
|
<strong>18</strong>
|
|
</span>(3):724–30.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/17378600" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 17378600</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>2.</dt><dd><div class="bk_ref" id="MP2346Cu64.EXTYLES.2">Smith C.J. , Gali H. , Sieckman G.L. , Higginbotham C. , Volkert W.A. , Hoffman T.J. Radiochemical investigations of (99m)Tc-N(3)S-X-BBN[7-14]NH(2): an in vitro/in vivo structure-activity relationship study where X = 0-, 3-, 5-, 8-, and 11-carbon tethering moieties. <span><span class="ref-journal">Bioconjug Chem. </span>2003;<span class="ref-vol">
|
|
<strong>14</strong>
|
|
</span>(1):93–102.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/12526698" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 12526698</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>3.</dt><dd><div class="bk_ref" id="MP2346Cu64.EXTYLES.3">Ma L. , Yu P. , Veerendra B. , Rold T.L. , Retzloff L. , Prasanphanich A. , Sieckman G. , Hoffman T.J. , Volkert W.A. , Smith C.J. In Vitro and In Vivo Evaluation of Alexa Fluor 680-Bombesin[7-14]NH(2) Peptide Conjugate, a High-Affinity Fluorescent Probe with High Selectivity for the Gastrin-Releasing Peptide Receptor. <span><span class="ref-journal">Mol Imaging. </span>2007;<span class="ref-vol">
|
|
<strong>6</strong>
|
|
</span>(3):171–80.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/17532883" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 17532883</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>4.</dt><dd><div class="bk_ref" id="MP2346Cu64.EXTYLES.4">Mantey S. , Frucht H. , Coy D.H. , Jensen R.T. Characterization of bombesin receptors using a novel, potent, radiolabeled antagonist that distinguishes bombesin receptor subtypes. <span><span class="ref-journal">Mol Pharmacol. </span>1993;<span class="ref-vol">
|
|
<strong>43</strong>
|
|
</span>(5):762–74.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/7684815" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 7684815</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>5.</dt><dd><div class="bk_ref" id="MP2346Cu64.EXTYLES.5">Benya R.V. , Kusui T. , Pradhan T.K. , Battey J.F. , Jensen R.T. Expression and characterization of cloned human bombesin receptors. <span><span class="ref-journal">Mol Pharmacol. </span>1995;<span class="ref-vol">
|
|
<strong>47</strong>
|
|
</span>(1):10–20.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/7838118" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 7838118</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>6.</dt><dd><div class="bk_ref" id="MP2346Cu64.EXTYLES.6">Reubi J.C. , Wenger S. , Schmuckli-Maurer J. , Schaer J.C. , Gugger M. Bombesin receptor subtypes in human cancers: detection with the universal radioligand (125)I-[D-TYR(6), beta-ALA(11), PHE(13), NLE(14)] bombesin(6-14). <span><span class="ref-journal">Clin Cancer Res. </span>2002;<span class="ref-vol">
|
|
<strong>8</strong>
|
|
</span>(4):1139–46.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/11948125" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 11948125</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>7.</dt><dd><div class="bk_ref" id="MP2346Cu64.EXTYLES.7">Smith C.J. , Volkert W.A. , Hoffman T.J. Radiolabeled peptide conjugates for targeting of the bombesin receptor superfamily subtypes. <span><span class="ref-journal">Nucl Med Biol. </span>2005;<span class="ref-vol">
|
|
<strong>32</strong>
|
|
</span>(7):733–40.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/16243649" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 16243649</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>8.</dt><dd><div class="bk_ref" id="MP2346Cu64.EXTYLES.8">Nock B. , Nikolopoulou A. , Chiotellis E. , Loudos G. , Maintas D. , Reubi J.C. , Maina T. [99mTc]Demobesin 1, a novel potent bombesin analogue for GRP receptor-targeted tumour imaging. <span><span class="ref-journal">Eur J Nucl Med Mol Imaging. </span>2003;<span class="ref-vol">
|
|
<strong>30</strong>
|
|
</span>(2):247–58.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/12552343" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 12552343</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>9.</dt><dd><div class="bk_ref" id="MP2346Cu64.EXTYLES.9">Smith C.J. , Volkert W.A. , Hoffman T.J. Gastrin releasing peptide (GRP) receptor targeted radiopharmaceuticals: a concise update. <span><span class="ref-journal">Nucl Med Biol. </span>2003;<span class="ref-vol">
|
|
<strong>30</strong>
|
|
</span>(8):861–8.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/14698790" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 14698790</span></a>]</div></dd></dl><li><div class="bk_ref" id="MP2346Cu64.EXTYLES.10">10. de Visser, M., H.F. Bernard, J.L. Erion, M.A. Schmidt, A. Srinivasan, B. Waser, J.C. Reubi, E.P. Krenning, and M. de Jong, Novel (111)In-labelled bombesin analogues for molecular imaging of prostate tumours. Eur J Nucl Med Mol Imaging, 2007. [<a href="https://pubmed.ncbi.nlm.nih.gov/17287960" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 17287960</span></a>]</div></li><dl class="bkr_refwrap"><dt>11.</dt><dd><div class="bk_ref" id="MP2346Cu64.EXTYLES.11">Ferro-Flores G. , Arteaga de Murphy C. , Rodriguez-Cortes J. , Pedraza-Lopez M. , Ramirez-Iglesias M.T. Preparation and evaluation of 99mTc-EDDA/HYNIC-[Lys 3]-bombesin for imaging gastrin-releasing peptide receptor-positive tumours. <span><span class="ref-journal">Nucl Med Commun. </span>2006;<span class="ref-vol">
|
|
<strong>27</strong>
|
|
</span>(4):371–6.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/16531924" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 16531924</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>12.</dt><dd><div class="bk_ref" id="MP2346Cu64.EXTYLES.12">Breeman W.A. , Bakker W.H. , De Jong M. , Hofland L.J. , Kwekkeboom D.J. , Kooij P.P. , Visser T.J. , Krenning E.P. Studies on radiolabeled somatostatin analogues in rats and in patients. <span><span class="ref-journal">Q J Nucl Med. </span>1996;<span class="ref-vol">
|
|
<strong>40</strong>
|
|
</span>(3):209–20.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/8961800" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 8961800</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>13.</dt><dd><div class="bk_ref" id="MP2346Cu64.EXTYLES.13">Zhang X. , Cai W. , Cao F. , Schreibmann E. , Wu Y. , Wu J.C. , Xing L. , Chen X. 18F-labeled bombesin analogs for targeting GRP receptor-expressing prostate cancer. <span><span class="ref-journal">J Nucl Med. </span>2006;<span class="ref-vol">
|
|
<strong>47</strong>
|
|
</span>(3):492–501.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/16513619" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 16513619</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>14.</dt><dd><div class="bk_ref" id="MP2346Cu64.EXTYLES.14">Breeman W.A. , De Jong M. , Bernard B.F. , Kwekkeboom D.J. , Srinivasan A. , van der Pluijm M.E. , Hofland L.J. , Visser T.J. , Krenning E.P. Pre-clinical evaluation of [(111)In-DTPA-Pro(1), Tyr(4)]bombesin, a new radioligand for bombesin-receptor scintigraphy. <span><span class="ref-journal">Int J Cancer. </span>1999;<span class="ref-vol">
|
|
<strong>83</strong>
|
|
</span>(5):657–63.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/10521803" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 10521803</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>15.</dt><dd><div class="bk_ref" id="MP2346Cu64.EXTYLES.15">Breeman W.A. , de Jong M. , Erion J.L. , Bugaj J.E. , Srinivasan A. , Bernard B.F. , Kwekkeboom D.J. , Visser T.J. , Krenning E.P. Preclinical comparison of (111)In-labeled DTPA- or DOTA-bombesin analogs for receptor-targeted scintigraphy and radionuclide therapy. <span><span class="ref-journal">J Nucl Med. </span>2002;<span class="ref-vol">
|
|
<strong>43</strong>
|
|
</span>(12):1650–6.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/12468515" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 12468515</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>16.</dt><dd><div class="bk_ref" id="MP2346Cu64.EXTYLES.16">Chen X. , Park R. , Hou Y. , Tohme M. , Shahinian A.H. , Bading J.R. , Conti P.S. microPET and autoradiographic imaging of GRP receptor expression with 64Cu-DOTA-[Lys3]bombesin in human prostate adenocarcinoma xenografts. <span><span class="ref-journal">J Nucl Med. </span>2004;<span class="ref-vol">
|
|
<strong>45</strong>
|
|
</span>(8):1390–7.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/15299066" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 15299066</span></a>]</div></dd></dl></dl></div><div><dl class="temp-labeled-list small"><dl class="bkr_refwrap"><dt></dt><dd><div><p class="no_top_margin"><div>This MICAD chapter is not included in the Open Access Subset, because it was authored / co-authored by one or more investigators who was not a member of the MICAD staff.</div></p></div></dd></dl></dl></div><div id="bk_toc_contnr"></div></div></div><div class="fm-sec"><h2 id="_NBK23640_pubdet_">Publication Details</h2><h3>Author Information and Affiliations</h3><div class="contrib half_rhythm"><span itemprop="author">Kenneth T. Cheng</span>, PhD<div class="affiliation small">
|
|
National Center for Biotechnology Information, NLM, NIH, Bethesda, MD,
|
|
<span class="before-email-separator"></span><span class="email-label">Email: </span><a href="mailto:dev@null" data-email="vog.hin.mln.ibcn@dacim" class="oemail">vog.hin.mln.ibcn@dacim</a>
|
|
</div></div><div class="contrib half_rhythm"><span itemprop="author">Jason S. Lewis</span>, PhD<div class="affiliation small">
|
|
Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO, Corresponding Author,
|
|
<span class="before-email-separator"></span><span class="email-label">Email: </span><a href="mailto:dev@null" data-email="ude.ltsuw@siwel.s.j" class="oemail">ude.ltsuw@siwel.s.j</a>
|
|
</div></div><div class="contrib half_rhythm"><span itemprop="author">Gráinne B. Biddlecombe</span>, MS<div class="affiliation small">
|
|
Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO,
|
|
<span class="before-email-separator"></span><span class="email-label">Email: </span><a href="mailto:dev@null" data-email="ude.ltsuw.rim@gebmocelddib" class="oemail">ude.ltsuw.rim@gebmocelddib</a>
|
|
</div></div><h3>Publication History</h3><p class="small">Created: <span itemprop="datePublished">August 16, 2007</span>; Last Update: <span itemprop="dateModified">January 8, 2008</span>.</p><h3>Copyright</h3><div><div class="half_rhythm"><a href="/books/about/copyright/">Copyright Notice</a></div></div><h3>Publisher</h3><p><a href="http://www.ncbi.nlm.nih.gov/" ref="pagearea=page-banner&targetsite=external&targetcat=link&targettype=publisher">National Center for Biotechnology Information (US)</a>, Bethesda (MD)</p><h3>NLM Citation</h3><p>Cheng KT, Lewis JS, Biddlecombe GB. 64Cu-DOTA-[Pro1,Tyr4]-Bombesin[1-14] 2007 Aug 16 [Updated 2008 Jan 8]. In: Molecular Imaging and Contrast Agent Database (MICAD) [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2004-2013. <span class="bk_cite_avail"></span></p></div><div class="small-screen-prev"><a href="/books/n/micad/Cu64-DTPA-ProT/?report=reader"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 100 100" preserveAspectRatio="none"><path d="M75,30 c-80,60 -80,0 0,60 c-30,-60 -30,0 0,-60"></path><text x="20" y="28" textLength="60" style="font-size:25px">Prev</text></svg></a></div><div class="small-screen-next"><a href="/books/n/micad/TrastFv-FcDM64Cu/?report=reader"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 100 100" preserveAspectRatio="none"><path d="M25,30c80,60 80,0 0,60 c30,-60 30,0 0,-60"></path><text x="20" y="28" textLength="60" style="font-size:25px">Next</text></svg></a></div></article><article data-type="table-wrap" id="figobMP2346Cu64T1"><div id="MP2346Cu64.T1" class="table"><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK23640/table/MP2346Cu64.T1/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__MP2346Cu64.T1_lrgtbl__"><table><tbody><tr><td rowspan="1" colspan="1" style="text-align:right;vertical-align:top;">
|
|
<b>Chemical name:</b>
|
|
</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"><sup>64</sup>Cu-DOTA-[Pro<sup>1</sup>,Tyr<sup>4</sup>]-Bombesin[1-14]</td><td rowspan="9" colspan="1" style="text-align:left;vertical-align:middle;">
|
|
<a href="https://pubchem.ncbi.nlm.nih.gov/substance/26697031" title="View this structure in PubChem" class="img_link" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem"><img src="https://pubchem.ncbi.nlm.nih.gov/image/imgsrv.fcgi?t=l&sid=26697031" alt="image 26697031 in the ncbi pubchem database" /></a>
|
|
</td></tr><tr><td rowspan="1" colspan="1" style="text-align:right;vertical-align:top;">
|
|
<b>Abbreviated name:</b>
|
|
</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"><sup>64</sup>Cu-MP2346</td></tr><tr><td rowspan="1" colspan="1" style="text-align:right;vertical-align:top;">
|
|
<b>Synonym:</b>
|
|
</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"><sup>64</sup>Cu-Bombesin, <sup>64</sup>Cu-BN, <sup>64</sup>Cu-BNN</td></tr><tr><td rowspan="1" colspan="1" style="text-align:right;vertical-align:top;">
|
|
<b>Agent Category:</b>
|
|
</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Peptide</td></tr><tr><td rowspan="1" colspan="1" style="text-align:right;vertical-align:top;">
|
|
<b>Target:</b>
|
|
</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Gastrin-releasing peptide receptor (GRP-R)</td></tr><tr><td rowspan="1" colspan="1" style="text-align:right;vertical-align:top;">
|
|
<b>Target Category:</b>
|
|
</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Receptor binding</td></tr><tr><td rowspan="1" colspan="1" style="text-align:right;vertical-align:top;">
|
|
<b>Method of detection:</b>
|
|
</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Positron emission tomography (PET) imaging</td></tr><tr><td rowspan="1" colspan="1" style="text-align:right;vertical-align:top;">
|
|
<b>Source of signal/ contrast:</b>
|
|
</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"><sup>64</sup>Cu</td></tr><tr><td rowspan="1" colspan="1" style="text-align:right;vertical-align:top;">
|
|
<b>Activation:</b>
|
|
</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">No</td></tr><tr><td rowspan="1" colspan="1" style="text-align:right;vertical-align:top;">
|
|
<b>Studies:</b>
|
|
</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<ul class="simple-list"><li class="half_rhythm"><div>
|
|
<img alt="Checkbox" src="/corehtml/pmc/css/bookshelf/2.26/img/studies.checkbox.png" />
|
|
<i>In vitro</i>
|
|
|
|
</div></li></ul>
|
|
<ul class="simple-list"><li class="half_rhythm"><div>
|
|
<img alt="Checkbox" src="/corehtml/pmc/css/bookshelf/2.26/img/studies.checkbox.png" /> Rodents
|
|
</div></li></ul>
|
|
<br />
|
|
</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Click on the above structure for additional information in <a href="http://pubchem.ncbi.nlm.nih.gov" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">PubChem</a>.<br />Click on <a href="/entrez/viewer.fcgi?db=protein&id=55584176" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">protein</a>, <a href="/entrez/viewer.fcgi?db=nuccore&id=61677286" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">nucleotide</a> (RefSeq), and <a href="/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2925&ordinalpos=5&itool=EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVDocSum" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">gene</a> for more information about BN and GRP.</td></tr></tbody></table></div></div></article></div><div id="jr-scripts"><script src="/corehtml/pmc/jatsreader/ptpmc_3.22/js/libs.min.js"> </script><script src="/corehtml/pmc/jatsreader/ptpmc_3.22/js/jr.min.js"> </script></div></div>
|
|
|
|
|
|
|
|
|
|
<!-- Book content -->
|
|
|
|
<script type="text/javascript" src="/portal/portal3rc.fcgi/rlib/js/InstrumentNCBIBaseJS/InstrumentPageStarterJS.js"> </script>
|
|
|
|
|
|
<!-- CE8B5AF87C7FFCB1_0191SID /projects/books/PBooks@9.11 portal105 v4.1.r689238 Tue, Oct 22 2024 16:10:51 -->
|
|
<span id="portal-csrf-token" style="display:none" data-token="CE8B5AF87C7FFCB1_0191SID"></span>
|
|
|
|
<script type="text/javascript" src="//static.pubmed.gov/portal/portal3rc.fcgi/4216699/js/3968615.js" snapshot="books"></script></body>
|
|
</html>
|