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<script type="text/javascript" src="/corehtml/pmc/jatsreader/ptpmc_3.22/js/jr.boots.min.js"> </script><title>Microbubbles conjugated with anti-matrix metalloproteinase 2 mouse monoclonal antibody sc-13595 - Molecular Imaging and Contrast Agent Database (MICAD) - NCBI Bookshelf</title>
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<meta name="citation_title" content="Microbubbles conjugated with anti-matrix metalloproteinase 2 mouse monoclonal antibody sc-13595">
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<meta name="citation_date" content="2011/11/17">
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<meta name="citation_author" content="Kam Leung">
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<meta name="DC.Contributor" content="Kam Leung">
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<meta name="description" content="Ultrasound is the most widely used imaging modality (1), and its role in noninvasive molecular imaging is expanding with ligand-carrying microbubbles (MBs) (2). MBs are composed of spherical cavities filled with a gas encapsulated in a shell. The shells are made of phospholipids, surfactant, denatured human serum albumin, or synthetic polymer. Ligands and antibodies can be incorporated into the shell surface of MBs. MBs are usually 1–8 μm in diameter, and they provide a strongly reflective interface and resonate to ultrasound waves. MBs are used as ultrasound contrast agents in imaging of inflammation, angiogenesis, intravascular thrombus, and tumors (3-5). They also have the potential to be used for drug and gene delivery (6).">
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<meta name="og:description" content="Ultrasound is the most widely used imaging modality (1), and its role in noninvasive molecular imaging is expanding with ligand-carrying microbubbles (MBs) (2). MBs are composed of spherical cavities filled with a gas encapsulated in a shell. The shells are made of phospholipids, surfactant, denatured human serum albumin, or synthetic polymer. Ligands and antibodies can be incorporated into the shell surface of MBs. MBs are usually 1–8 μm in diameter, and they provide a strongly reflective interface and resonate to ultrasound waves. MBs are used as ultrasound contrast agents in imaging of inflammation, angiogenesis, intravascular thrombus, and tumors (3-5). They also have the potential to be used for drug and gene delivery (6).">
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id="jr-fip-info-p"><a id="jr-fip-prev" class="wsprkl btn" title="Jump to previuos match">◀</a><button id="jr-fip-matches">no matches yet</button><a id="jr-fip-next" class="wsprkl btn" title="Jump to next match">▶</a></nav></nav></div><div id="jr-epub-interstitial" class="hidden"></div><div id="jr-content"><article data-type="main"><div class="main-content lit-style" itemscope="itemscope" itemtype="http://schema.org/CreativeWork"><div class="meta-content fm-sec"><div class="fm-sec"><h1 id="_NBK66164_"><span class="title" itemprop="name">Microbubbles conjugated with anti-matrix metalloproteinase 2 mouse monoclonal antibody sc-13595</span></h1><div itemprop="alternativeHeadline" class="subtitle whole_rhythm">MMP2-MBs</div><p class="contribs">Leung K.</p><p class="fm-aai"><a href="#_NBK66164_pubdet_">Publication Details</a></p></div></div><div class="jig-ncbiinpagenav body-content whole_rhythm" data-jigconfig="allHeadingLevels: ['h2'],smoothScroll: false" itemprop="text"><div class="iconblock whole_rhythm clearfix ten_col table-wrap" id="figMMP2MBTncchemicalnamemicrobubblesc"><a href="/books/NBK66164/table/MMP2-MB.T.nc_chemical_namemicrobubbles_c/?report=objectonly" target="object" title="Table" class="img_link icnblk_img figpopup" rid-figpopup="figMMP2MBTncchemicalnamemicrobubblesc" rid-ob="figobMMP2MBTncchemicalnamemicrobubblesc"><img class="small-thumb" src="/books/NBK66164/table/MMP2-MB.T.nc_chemical_namemicrobubbles_c/?report=thumb" src-large="/books/NBK66164/table/MMP2-MB.T.nc_chemical_namemicrobubbles_c/?report=previmg" alt="Image " /></a><div class="icnblk_cntnt"><h4 id="MMP2-MB.T.nc_chemical_namemicrobubbles_c"><a href="/books/NBK66164/table/MMP2-MB.T.nc_chemical_namemicrobubbles_c/?report=objectonly" target="object" rid-ob="figobMMP2MBTncchemicalnamemicrobubblesc">Table</a></h4><p class="float-caption no_bottom_margin">
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<i>In vitro</i>
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Rodents
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</p></div></div><div id="MMP2-MB.Background"><h2 id="_MMP2-MB_Background_">Background</h2><p>[<a href="/sites/entrez?Db=pubmed&Cmd=DetailsSearch&Term=matrix%20metalloproteinase%202%20microbubbles" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">PubMed</a>]</p><p>Ultrasound is the most widely used imaging modality (<a class="bibr" href="#MMP2-MB.REF.1" rid="MMP2-MB.REF.1">1</a>), and its role in noninvasive molecular imaging is expanding with ligand-carrying microbubbles (MBs) (<a class="bibr" href="#MMP2-MB.REF.2" rid="MMP2-MB.REF.2">2</a>). MBs are composed of spherical cavities filled with a gas encapsulated in a shell. The shells are made of phospholipids, surfactant, denatured human serum albumin, or synthetic polymer. Ligands and antibodies can be incorporated into the shell surface of MBs. MBs are usually 1–8 μm in diameter, and they provide a strongly reflective interface and resonate to ultrasound waves. MBs are used as ultrasound contrast agents in imaging of inflammation, angiogenesis, intravascular thrombus, and tumors (<a class="bibr" href="#MMP2-MB.REF.3" rid="MMP2-MB.REF.3 MMP2-MB.REF.4 MMP2-MB.REF.5">3-5</a>). They also have the potential to be used for drug and gene delivery (<a class="bibr" href="#MMP2-MB.REF.6" rid="MMP2-MB.REF.6">6</a>).</p><p>Extracellular matrix (ECM) adhesion molecules consist of a complex network of fibronectins, collagens, chondroitins, laminins, glycoproteins, heparin sulfate, tenascins, and proteoglycans that surround connective tissue cells, and they are mainly secreted by fibroblasts, chondroblasts, and osteoblasts (<a class="bibr" href="#MMP2-MB.REF.7" rid="MMP2-MB.REF.7">7</a>). Cell substrate adhesion molecules are considered essential regulators of cell migration, differentiation, and tissue integrity and remodeling. These molecules play a role in inflammation and atherogenesis, but they also participate in the process of invasion and metastasis of malignant cells in the host tissue (<a class="bibr" href="#MMP2-MB.REF.8" rid="MMP2-MB.REF.8">8</a>). Invasive tumor cells adhere to the ECM, which provides a matrix environment for permeation of tumor cells through the basal lamina and underlying interstitial stroma of the connective tissue. Overexpression of matrix metalloproteinases (MMPs) and other proteases by tumor cells allows intravasation of tumor cells into the circulatory system after degrading the basement membrane and ECM (<a class="bibr" href="#MMP2-MB.REF.9" rid="MMP2-MB.REF.9">9</a>).</p><p>Several families of MMPs are involved in atherogenesis, myocardial infarction, angiogenesis, and tumor invasion and metastases (<a class="bibr" href="#MMP2-MB.REF.10" rid="MMP2-MB.REF.10 MMP2-MB.REF.11 MMP2-MB.REF.12">10-12</a>). MMP expression in normal cells, such as trophoblasts, osteoclasts, neutrophils, and macrophages, is highly regulated. Elevated levels of MMPs have been found in tumors associated with a poor prognosis for cancer patients (<a class="bibr" href="#MMP2-MB.REF.13" rid="MMP2-MB.REF.13">13</a>). MMP2 is one of the major enzymes involved in the remodeling of the left ventricle after ischemia and reperfusion (I/R) in the heart (<a class="bibr" href="#MMP2-MB.REF.14" rid="MMP2-MB.REF.14">14</a>). Su et al. (<a class="bibr" href="#MMP2-MB.REF.15" rid="MMP2-MB.REF.15">15</a>) conjugated anti-MMP2 mouse monoclonal antibody sc-13595 to microbubbles containing polyethylene glycol (PEG) (MMP2-MBs) for contrast-enhanced ultrasound imaging of MMP2 expression in a post-I/R remodeling rat model.</p><div id="MMP2-MB.Related_Resource_Links"><h3>Related Resource Links:</h3><ul><li class="half_rhythm"><div>Chapters in MICAD (<a href="/sites/entrez?Db=books&Cmd=DetailsSearch&Term=MMP+AND+micad%5Bbook%5D" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">MMP</a>)</div></li><li class="half_rhythm"><div>Gene information in NCBI (<a href="/gene/4313" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">MMP2</a>)</div></li><li class="half_rhythm"><div>Articles in Online Mendelian Inheritance in Man (OMIM) (<a href="/omim/120360" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">MMP2</a>)</div></li><li class="half_rhythm"><div>Clinical trials (<a href="http://www.clinicaltrials.gov/ct2/results?term=matrix+metalloproteinases+" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">MMP</a>)</div></li><li class="half_rhythm"><div>Drug information in FDA (<a href="http://google2.fda.gov/search?q=matrix+metalloproteinases+&client=FDAgov&site=FDAgov&lr=&proxystylesheet=FDAgov&output=xml_no_dtd&getfields=*&x=10&y=10" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">MMP</a>)</div></li></ul></div></div><div id="MMP2-MB.Synthesis"><h2 id="_MMP2-MB_Synthesis_">Synthesis</h2><p>[<a href="/sites/entrez?Db=pubmed&Cmd=DetailsSearch&Term=matrix%20metalloproteinase%202%20microbubbles+synthesis" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">PubMed</a>]</p><p>Su et al. (<a class="bibr" href="#MMP2-MB.REF.15" rid="MMP2-MB.REF.15">15</a>) reported the preparation of MMP2-MBs. Hexafluoride gas was dispersed by sonication of an aqueous solution of PEG, sorbitan sterate, and Tween-80 to form a PEG contrast MB (MB<sub>c</sub>). MMP2 monoclonal antibody sc-13595 (~1.4 nmol) was incubated with 1 × 10<sup>7</sup> MB<sub>c</sub> for 10 min at 4°C. Unbounded antibody was removed from MMP2-MBs by centrifugal washings. MMP2-MBs had a mean diameter of 3.36 ± 1.61 µm. Attachment of antibody to the MB shell was confirmed with flow cytometry and microscopy. The number of antibody molecules per MB was not reported.</p></div><div id="MMP2-MB.In_Vitro_Studies_Testing_in_Cell"><h2 id="_MMP2-MB_In_Vitro_Studies_Testing_in_Cell_"><i>In Vitro</i> Studies: Testing in Cells and Tissues</h2><p>[<a href="/sites/entrez?Db=pubmed&Cmd=DetailsSearch&Term=matrix%20metalloproteinase%202%20microbubbles+in+vitro+studies" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">PubMed</a>]</p><p>Su et al. (<a class="bibr" href="#MMP2-MB.REF.15" rid="MMP2-MB.REF.15">15</a>) performed <i>in vitro</i> binding of MB<sub>c</sub> and MMP2-Mbs to myocardial tissue sections from normal rats and 1-week post-I/R rats. MMP2-Mbs bound abundantly within the risk area of I/R myocardial sections with rare binding in the control area. Little binding was observed with MB<sub>c</sub> in the risk area or control area. No binding was observed with MB<sub>c</sub> and MMP2-MBs in the myocardial sections of control rats.</p></div><div id="MMP2-MB.Animal_Studies"><h2 id="_MMP2-MB_Animal_Studies_">Animal Studies</h2><div id="MMP2-MB.Rodents"><h3>Rodents</h3><p>[<a href="/sites/entrez?Db=pubmed&Cmd=DetailsSearch&Term=matrix%20metalloproteinase%202%20microbubbles+rodentia" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">PubMed</a>]</p><p>Su et al. (<a class="bibr" href="#MMP2-MB.REF.15" rid="MMP2-MB.REF.15">15</a>) performed ultrasound studies of MB<sub>c</sub> and MMP2-MBs binding in normal rats (<i>n</i> = 3/group) and 1-week post-I/R rats (<i>n</i> = 3/group). Myocardial contrast echocardiography was first performed to induce microvascular permeability in the heart tissue. Ultrasound was then performed at 10 min after injection of MB<sub>c</sub> or MMP2-MBs (2 × 10<sup>6</sup>/rat). The mean myocardial video intensity in the risk area were 1.02 ± 0.19 and 1.76 ± 0.25 for MB<sub>c</sub> and MMP2-MBs, respectively. The contrast enhancement of MMP2-MBs to the risk area was significantly higher than that of MB<sub>c</sub> (<i>P</i> < 0.01). No retention of MB<sub>c</sub> (1.01 ± 0.11) or MMP2-MBs (1.02 ± 0.14) was observed in the myocardial tissue of control rats. Histological and immunofluorescence staining confirmed the co-localization of MMP2-MBs to MMP2 in the risk area of 1-week post-I/R rats. No retention of MB<sub>c</sub> was observed in the risk area, and no retention of MMP2-MBs was observed in the control area. No blocking studies were performed.</p></div><div id="MMP2-MB.Other_NonPrimate_Mammals"><h3>Other Non-Primate Mammals</h3><p>[<a href="/entrez/query.fcgi?cmd=PureSearch&db=pubmed&details_term=matrix%20metalloproteinase%202%20microbubbles%20and%20%28dog%20or%20pig%20or%20sheep%20or%20rabbit%29" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">PubMed</a>]</p><p>No references are currently available.</p></div><div id="MMP2-MB.NonHuman_Primates"><h3>Non-Human Primates</h3><p>[<a href="/sites/entrez?Db=pubmed&Cmd=DetailsSearch&Term=matrix%20metalloproteinase%202%20microbubbles+Non+Human+Primates" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">PubMed</a>]</p><p>No references are currently available.</p></div></div><div id="MMP2-MB.Human_Studies"><h2 id="_MMP2-MB_Human_Studies_">Human Studies</h2><p>[<a href="/sites/entrez?Db=pubmed&Cmd=DetailsSearch&Term=matrix%20metalloproteinase%202%20microbubbles+Human+Studies" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">PubMed</a>]</p><p>No references are currently available.</p></div><div id="MMP2-MB.References"><h2 id="_MMP2-MB_References_">References</h2><dl class="temp-labeled-list"><dl class="bkr_refwrap"><dt>1.</dt><dd><div class="bk_ref" id="MMP2-MB.REF.1">Wells P.N.
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<span><span class="ref-journal">Med Eng Phys. </span>2001;<span class="ref-vol">23</span>(3):147–53.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/11410379" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 11410379</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>2.</dt><dd><div class="bk_ref" id="MMP2-MB.REF.2">Liang H.D., Blomley M.J.
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<em>The role of ultrasound in molecular imaging.</em>
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<span><span class="ref-journal">Br J Radiol. </span>2003;<span class="ref-vol">76</span>(Spec No 2):S140–50.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/15572336" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 15572336</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>3.</dt><dd><div class="bk_ref" id="MMP2-MB.REF.3">Klibanov A.L.
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<em>Ligand-carrying gas-filled microbubbles: ultrasound contrast agents for targeted molecular imaging.</em>
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<span><span class="ref-journal">Bioconjug Chem. </span>2005;<span class="ref-vol">16</span>(1):9–17.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/15656569" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 15656569</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>4.</dt><dd><div class="bk_ref" id="MMP2-MB.REF.4">Lindner J.R.
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<em>Microbubbles in medical imaging: current applications and future directions.</em>
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<span><span class="ref-journal">Nat Rev Drug Discov. </span>2004;<span class="ref-vol">3</span>(6):527–32.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/15173842" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 15173842</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>5.</dt><dd><div class="bk_ref" id="MMP2-MB.REF.5">Villanueva F.S., Wagner W.R., Vannan M.A., Narula J.
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<em>Targeted ultrasound imaging using microbubbles.</em>
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<span><span class="ref-journal">Cardiol Clin. </span>2004;<span class="ref-vol">22</span>(2):283–98.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/15158940" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 15158940</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>6.</dt><dd><div class="bk_ref" id="MMP2-MB.REF.6">Dijkmans P.A., Juffermans L.J., Musters R.J., van Wamel A., ten Cate F.J., van Gilst W., Visser C.A., de Jong N., Kamp O.
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<em>Microbubbles and ultrasound: from diagnosis to therapy.</em>
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<span><span class="ref-journal">Eur J Echocardiogr. </span>2004;<span class="ref-vol">5</span>(4):245–56.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/15219539" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 15219539</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>7.</dt><dd><div class="bk_ref" id="MMP2-MB.REF.7">Bosman F.T., Stamenkovic I.
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<em>Functional structure and composition of the extracellular matrix.</em>
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<span><span class="ref-journal">J Pathol. </span>2003;<span class="ref-vol">200</span>(4):423–8.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/12845610" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 12845610</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>8.</dt><dd><div class="bk_ref" id="MMP2-MB.REF.8">Jiang W.G., Puntis M.C., Hallett M.B.
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<em>Molecular and cellular basis of cancer invasion and metastasis: implications for treatment.</em>
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<em>Role of integrins and other cell adhesion molecules in tumor progression and metastasis.</em>
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<span><span class="ref-journal">Lab Invest. </span>1993;<span class="ref-vol">68</span>(1):4–17.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/8423675" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 8423675</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>10.</dt><dd><div class="bk_ref" id="MMP2-MB.REF.10">Berchem G., Glondu M., Gleizes M., Brouillet J.P., Vignon F., Garcia M., Liaudet-Coopman E.
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<em>Cathepsin-D affects multiple tumor progression steps in vivo: proliferation, angiogenesis and apoptosis.</em>
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<span><span class="ref-journal">Oncogene. </span>2002;<span class="ref-vol">21</span>(38):5951–5.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/12185597" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 12185597</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>11.</dt><dd><div class="bk_ref" id="MMP2-MB.REF.11">Brix, K., A. Dunkhorst, K. Mayer, and S. Jordans, <em>Cysteine cathepsins: Cellular roadmap to different functions.</em> Biochimie, 2007. [<a href="https://pubmed.ncbi.nlm.nih.gov/17825974" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 17825974</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>12.</dt><dd><div class="bk_ref" id="MMP2-MB.REF.12">Liu J., Sukhova G.K., Sun J.S., Xu W.H., Libby P., Shi G.P.
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<span><span class="ref-journal">Arterioscler Thromb Vasc Biol. </span>2004;<span class="ref-vol">24</span>(8):1359–66.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/15178558" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 15178558</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>13.</dt><dd><div class="bk_ref" id="MMP2-MB.REF.13">Deryugina E.I., Quigley J.P.
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<span><span class="ref-journal">Cancer Metastasis Rev. </span>2006;<span class="ref-vol">25</span>(1):9–34.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/16680569" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 16680569</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>14.</dt><dd><div class="bk_ref" id="MMP2-MB.REF.14">Wang W., Schulze C.J., Suarez-Pinzon W.L., Dyck J.R., Sawicki G., Schulz R.
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<span><span class="ref-journal">Mol Imaging Biol. </span>2011;<span class="ref-vol">13</span>(2):293–302.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/20544295" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 20544295</span></a>]</div></dd></dl></dl></div><div id="bk_toc_contnr"></div></div></div><div class="fm-sec"><h2 id="_NBK66164_pubdet_">Publication Details</h2><h3>Author Information and Affiliations</h3><div class="contrib half_rhythm"><span itemprop="author">Kam Leung</span>, PhD<div class="affiliation small">National Center for Biotechnology Information, NLM, NIH, Bethesda, MD<div><span class="email-label">Email: </span><a href="mailto:dev@null" data-email="vog.hin.mln.ibcn@dacim" class="oemail">vog.hin.mln.ibcn@dacim</a></div></div><div class="small">Corresponding author.</div></div><h3>Publication History</h3><p class="small">Created: <span itemprop="datePublished">August 15, 2011</span>; Last Update: <span itemprop="dateModified">November 17, 2011</span>.</p><h3>Copyright</h3><div><div class="half_rhythm"><a href="/books/about/copyright/">Copyright Notice</a></div></div><h3>Publisher</h3><p><a href="http://www.ncbi.nlm.nih.gov/" ref="pagearea=page-banner&targetsite=external&targetcat=link&targettype=publisher">National Center for Biotechnology Information (US)</a>, Bethesda (MD)</p><h3>NLM Citation</h3><p>Leung K. Microbubbles conjugated with anti-matrix metalloproteinase 2 mouse monoclonal antibody sc-13595. 2011 Aug 15 [Updated 2011 Nov 17]. In: Molecular Imaging and Contrast Agent Database (MICAD) [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2004-2013. <span class="bk_cite_avail"></span></p></div><div class="small-screen-prev"><a href="/books/n/micad/MBInt/?report=reader"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 100 100" preserveAspectRatio="none"><path d="M75,30 c-80,60 -80,0 0,60 c-30,-60 -30,0 0,-60"></path><text x="20" y="28" textLength="60" style="font-size:25px">Prev</text></svg></a></div><div class="small-screen-next"><a href="/books/n/micad/MB-cAbVCAM1-5/?report=reader"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 100 100" preserveAspectRatio="none"><path d="M25,30c80,60 80,0 0,60 c30,-60 30,0 0,-60"></path><text x="20" y="28" textLength="60" style="font-size:25px">Next</text></svg></a></div></article><article data-type="table-wrap" id="figobMMP2MBTncchemicalnamemicrobubblesc"><div id="MMP2-MB.T.nc_chemical_namemicrobubbles_c" class="table"><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK66164/table/MMP2-MB.T.nc_chemical_namemicrobubbles_c/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__MMP2-MB.T.nc_chemical_namemicrobubbles_c_lrgtbl__"><table><tbody><tr><td rowspan="1" colspan="1" style="text-align:right;vertical-align:top;">
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<b>Chemical name:</b>
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</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Microbubbles conjugated with anti-matrix metalloproteinase 2 mouse monoclonal antibody sc-13595</td><td rowspan="9" colspan="1" style="text-align:center;vertical-align:middle;"></td></tr><tr><td rowspan="1" colspan="1" style="text-align:right;vertical-align:top;">
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<b>Abbreviated name:</b>
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</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">MMP2-MBs, TMB<sub>2</sub></td></tr><tr><td rowspan="1" colspan="1" style="text-align:right;vertical-align:top;">
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<b>Synonym:</b>
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</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td></tr><tr><td rowspan="1" colspan="1" style="text-align:right;vertical-align:top;">
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<b>Agent Category:</b>
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</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Antibody</td></tr><tr><td rowspan="1" colspan="1" style="text-align:right;vertical-align:top;">
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<b>Target:</b>
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</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Matrix metalloproteinase 2 (MMP2)</td></tr><tr><td rowspan="1" colspan="1" style="text-align:right;vertical-align:top;">
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<b>Target Category:</b>
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</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Enzyme</td></tr><tr><td rowspan="1" colspan="1" style="text-align:right;vertical-align:top;">
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<b>Method of detection:</b>
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</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Ultrasound</td></tr><tr><td rowspan="1" colspan="1" style="text-align:right;vertical-align:top;">
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<b>Source of signal / contrast:</b>
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</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Microbubbles (MBs)</td></tr><tr><td rowspan="1" colspan="1" style="text-align:right;vertical-align:top;">
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<b>Activation:</b>
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</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">No</td></tr><tr><td rowspan="1" colspan="1" style="text-align:right;vertical-align:top;">
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<b>Studies:</b>
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</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<ul class="simple-list"><li class="half_rhythm"><div>
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<img alt="Checkbox" src="/corehtml/pmc/css/bookshelf/2.26/img/studies.checkbox.png" />
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<i>In vitro</i>
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</div></li><li class="half_rhythm"><div>
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<img alt="Checkbox" src="/corehtml/pmc/css/bookshelf/2.26/img/studies.checkbox.png" /> Rodents
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</div></li></ul>
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</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">No structure is currently available in <a href="http://pubchem.ncbi.nlm.nih.gov/" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">PubChem</a>.</td></tr></tbody></table></div></div></article></div><div id="jr-scripts"><script src="/corehtml/pmc/jatsreader/ptpmc_3.22/js/libs.min.js"> </script><script src="/corehtml/pmc/jatsreader/ptpmc_3.22/js/jr.min.js"> </script></div></div>
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