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<script type="text/javascript" src="/corehtml/pmc/jatsreader/ptpmc_3.22/js/jr.boots.min.js"> </script><title>Microbubbles coated with antibody to intracellular adhesion molecule-1 - Molecular Imaging and Contrast Agent Database (MICAD) - NCBI Bookshelf</title>
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<meta name="citation_date" content="2012/04/17">
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<meta name="citation_author" content="Kam Leung">
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<meta name="og:description" content="Ultrasound is widely used imaging modality (1) and is expanding its role in noninvasive molecular imaging with ligand-carrying microbubbles (2). Microbubbles are comprised of spherical cavities filled by a gas encapsulated in a shell. The shells are made of phospholipids, surfactant, denatured human serum albumin or synthetic polymer. Ligands and antibodies can be incorporated into the shell surface of microbubbles. Microbubbles are usually 2 to 8 μm in size. They provide a strongly reflective interface and resonate to ultrasound waves. They are used as ultrasound contrast agents in imaging of inflammation, angiogenesis, intravascular thrombus, and tumors (3-5). They are also potentially used for drug and gene delivery (6).">
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id="jr-fip-info-p"><a id="jr-fip-prev" class="wsprkl btn" title="Jump to previuos match">◀</a><button id="jr-fip-matches">no matches yet</button><a id="jr-fip-next" class="wsprkl btn" title="Jump to next match">▶</a></nav></nav></div><div id="jr-epub-interstitial" class="hidden"></div><div id="jr-content"><article data-type="main"><div class="main-content lit-style" itemscope="itemscope" itemtype="http://schema.org/CreativeWork"><div class="meta-content fm-sec"><div class="fm-sec"><h1 id="_NBK24611_"><span class="title" itemprop="name">Microbubbles coated with antibody to intracellular adhesion molecule-1</span></h1><div itemprop="alternativeHeadline" class="subtitle whole_rhythm">MB<sub>ICAM-1</sub></div><p class="contribs">Leung K.</p><p class="fm-aai"><a href="#_NBK24611_pubdet_">Publication Details</a></p></div></div><div class="jig-ncbiinpagenav body-content whole_rhythm" data-jigconfig="allHeadingLevels: ['h2'],smoothScroll: false" itemprop="text"><div class="iconblock whole_rhythm clearfix ten_col table-wrap" id="figMBICAM1Tncchemicalnamemicrobubbles"><a href="/books/NBK24611/table/MB-ICAM-1.T.nc_chemical_namemicrobubbles/?report=objectonly" target="object" title="Table" class="img_link icnblk_img" rid-ob="figobMBICAM1Tncchemicalnamemicrobubbles"><img class="small-thumb" src="/corehtml/pmc/css/bookshelf/2.26/img/table-icon.gif" alt="Table Icon" /></a><div class="icnblk_cntnt"><h4 id="MB-ICAM-1.T.nc_chemical_namemicrobubbles"><a href="/books/NBK24611/table/MB-ICAM-1.T.nc_chemical_namemicrobubbles/?report=objectonly" target="object" rid-ob="figobMBICAM1Tncchemicalnamemicrobubbles">Table</a></h4><p class="float-caption no_bottom_margin">
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<i>In vitro</i>
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Rodents
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</p></div></div><div id="MB-ICAM-1.Background"><h2 id="_MB-ICAM-1_Background_">Background</h2><p>[<a href="/entrez/query.fcgi?cmd=PureSearch&db=pubmed&details_term=Microbubbles%20and%20ICAM-1" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">PubMed</a>]</p><p>Ultrasound is widely used imaging modality (<a class="bibr" href="#MB-ICAM-1.REF.1" rid="MB-ICAM-1.REF.1">1</a>) and is expanding its role in noninvasive molecular imaging with ligand-carrying microbubbles (<a class="bibr" href="#MB-ICAM-1.REF.2" rid="MB-ICAM-1.REF.2">2</a>). Microbubbles are comprised of spherical cavities filled by a gas encapsulated in a shell. The shells are made of phospholipids, surfactant, denatured human serum albumin or synthetic polymer. Ligands and antibodies can be incorporated into the shell surface of microbubbles. Microbubbles are usually 2 to 8 μm in size. They provide a strongly reflective interface and resonate to ultrasound waves. They are used as ultrasound contrast agents in imaging of inflammation, angiogenesis, intravascular thrombus, and tumors (<a class="bibr" href="#MB-ICAM-1.REF.3" rid="MB-ICAM-1.REF.3 MB-ICAM-1.REF.4 MB-ICAM-1.REF.5">3-5</a>). They are also potentially used for drug and gene delivery (<a class="bibr" href="#MB-ICAM-1.REF.6" rid="MB-ICAM-1.REF.6">6</a>).</p><p>Endothelial cells are important cells in inflammatory responses (<a class="bibr" href="#MB-ICAM-1.REF.7" rid="MB-ICAM-1.REF.7 MB-ICAM-1.REF.8">7, 8</a>). Bacterial lipopolysaccharide, virus, inflammation, and tissue injury increase tumor necrosis factor α (TNFα), interleukin-1 (IL-1) and other cytokine and chemokine secretion. Leukocyte emigration from blood is dependent on their rolling along endothelial cell surfaces and subsequently adherence to endothelial cell surfaces. Inflammatory mediators and cytokines induce chemokine secretion from endothelial cells and other vascular cells and increase their expression of cell surface adhesion molecules, such as intracellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), integrins and selectins. Chemokines are chemotactic to leukocytes to sites of inflammation and tissue injury. The movements of leukocytes through endothelial junctions into the extravascular space are highly orchestrated through various interactions with different adhesion molecules on endothelial cells (<a class="bibr" href="#MB-ICAM-1.REF.9" rid="MB-ICAM-1.REF.9">9</a>).</p><p>ICAM-1 is found on cell surface of endothelial cells and other vascular cells, such as smooth muscle cells and fibroblasts (<a class="bibr" href="#MB-ICAM-1.REF.10" rid="MB-ICAM-1.REF.10 MB-ICAM-1.REF.11 MB-ICAM-1.REF.12 MB-ICAM-1.REF.13 MB-ICAM-1.REF.14">10-14</a>). It binds to counter-receptors on the cell-surface of leukocytes. IL-1 and TNFα increase ICAM-1 and other cell adhesion molecule expression on the vascular endothelial cells, leading to leukocyte adhesion to the activated endothelium. Microbubbles targeted with antibody against ICAM-1 are being developed as a noninvasive agent for ICAM-1 expression in vascular endothelial cells of dysfunctional endothelium (<a class="bibr" href="#MB-ICAM-1.REF.15" rid="MB-ICAM-1.REF.15 MB-ICAM-1.REF.16 MB-ICAM-1.REF.17 MB-ICAM-1.REF.18">15-18</a>).</p><div id="MB-ICAM-1.Related_Resource_Links"><h3>Related Resource Links:</h3><ul><li class="half_rhythm"><div>Chapters in MICAD (<a href="/sites/entrez?db=Books&cmd=Search&term=ICAM-1+AND+micad%5bbook%5d&doptcmdl=TOCView&log%24=booksrch&bname=micad" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">ICAM-1</a>)</div></li><li class="half_rhythm"><div>Gene information in NCBI (<a href="/gene/3383" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">ICAM-1</a>)</div></li><li class="half_rhythm"><div>Articles in Online Mendelian Inheritance in Man (OMIM) (<a href="/omim/147840" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">ICAM-1</a>)</div></li></ul></div></div><div id="MB-ICAM-1.Synthesis"><h2 id="_MB-ICAM-1_Synthesis_">Synthesis</h2><p>[<a href="/entrez/query.fcgi?cmd=PureSearch&db=pubmed&details_term=Microbubbles%20and%20ICAM-1%20and%20synthesis" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">PubMed</a>]</p><p>For targeted microbubbles, Weller et al. (<a class="bibr" href="#MB-ICAM-1.REF.17" rid="MB-ICAM-1.REF.17">17</a>) prepared biotinylated microbubbles by sonication of an aqueous dispersion of decafluorobutane gas, phosphatidylcholine, polyethyleneglycol-(PEG-) stearate, and phosphatidylethanolamine-biotin in a 2:1:1 ratio by weight. Microbubbles were combined with streptavidin, washed, and conjugated with biotinylated mouse monoclonal antibody against ICAM-1(MB<sub>ICAM-1</sub>) or isotype control monoclonal antibody (MB<sub>iso</sub>). Control lipid microbubbles (MB<sub>c</sub>) were also prepared. The microbubbles are about 3.4 ± 1.2 microns in diameter. An antibody to microbubble ratio was estimated to be 60,000 ± 5,000 by flow cytometry. Alternatively, the primary amino groups of antibody were covalently conjugated to the carboxylic groups on the microbubble shell, which has been activated with 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide (<a class="bibr" href="#MB-ICAM-1.REF.15" rid="MB-ICAM-1.REF.15">15</a>).</p></div><div id="MB-ICAM-1.In_Vitro_Studies_Testing_in_Ce"><h2 id="_MB-ICAM-1_In_Vitro_Studies_Testing_in_Ce_"><i>In Vitro</i> Studies: Testing in Cells and Tissues</h2><p>[<a href="/entrez/query.fcgi?cmd=PureSearch&db=pubmed&details_term=Microbubbles%20and%20ICAM-1%20and%20in%20vitro" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">PubMed</a>]</p><p>Villanueva et al. (<a class="bibr" href="#MB-ICAM-1.REF.15" rid="MB-ICAM-1.REF.15">15</a>) reported that MB<sub>ICAM-1</sub> (1<sup>_</sup>10 x 10<sup>8</sup>/ml) perfused through the flow chamber coated with endothelial cells at a wall shear rate of 25 s<sup>-1</sup>. There was a significantly greater number of MB<sub>ICAM-1</sub> attached to IL-1 activated endothelial cells (8.0 ± 3.5 microbubbles/cell) than to normal endothelial cells (0.21 ± 0.09 microbubbles/cell). The number of adherent MB<sub>ICAM-1</sub> to activated endothelial cell decreased to 2.6 ± 0.3 and 0.8 ± 0.4 at 100 and 1000 s<sup>-1</sup>, respectively. The number of MB<sub>ICAM-1</sub> adherent to normal endothelial cell was only 0.1 at 1000 s<sup>-1</sup>. MB<sub>c</sub> and MB<sub>iso</sub> attachment to both activated and normal endothelial cells were minimal (0.03-0.05) at 25 s<sup>-1</sup> and there were no significant changes at higher wall shear rates.</p><p>Weller et al. (<a class="bibr" href="#MB-ICAM-1.REF.16" rid="MB-ICAM-1.REF.16 MB-ICAM-1.REF.17 MB-ICAM-1.REF.19">16, 17, 19</a>) confirmed that microbubble shell antibody density and wall shear rate are critical parameters controlling microbubble targeted adhesion. Microbubble adhesion was significantly greater with greater anti-ICAM-1 antibody density of the microbubbles and greater ICAM-1 expression on the cell surface of the endothelial cells. On the other hand, microbubble adhesion to endothelial cells was inversely proportional to the wall shear rate. Therefore, accumulation and retention of MB<sub>ICAM-1</sub> is possible under physiologic flow conditions and is strongly influenced by shear stress and surface density of the target receptor.</p></div><div id="MB-ICAM-1.Animal_Studies"><h2 id="_MB-ICAM-1_Animal_Studies_">Animal Studies</h2><div id="MB-ICAM-1.Rodents"><h3>Rodents</h3><p>[<a href="/entrez/query.fcgi?cmd=PureSearch&db=pubmed&details_term=Microbubbles%20and%20ICAM-1%20and%20rodentia" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">PubMed</a>]</p><p>Weller et al. (<a class="bibr" href="#MB-ICAM-1.REF.16" rid="MB-ICAM-1.REF.16">16</a>) performed ultrasound assessment of acute cardiac transplant rejection with 2.5x10<sup>6</sup> MB<sub>ICAM-1</sub> by triggered myocardial contrast echocardiography in rats. Cardiac ultrasound imaging of rejecting allograft transplants (10 ± 4 U, n = 8) showed that video intensity signal was significantly higher (<i>P</i><0.01) than control isograft transplants (1 ± 4 U, n = 7) for MB<sub>ICAM-1</sub>. On the other hand, MB<sub>c</sub> exhibited a minimal contrast in both the allograft and isograft transplants. Postmortem histology confirmed that the rejecting allograft transplants had a significantly higher ICAM-1 expression than the control isograft transplants.</p><p>Reinhardt et al. (<a class="bibr" href="#MB-ICAM-1.REF.18" rid="MB-ICAM-1.REF.18">18</a>) performed ultrasound assessment of ICAM in experimental autoimmune encephalomyelitis (EAE) in rats by sensitive particle acoustic quantification (SPAQ), which allows qualification of microbubbles in high concentration and resolution in μm (<a class="bibr" href="#MB-ICAM-1.REF.20" rid="MB-ICAM-1.REF.20">20</a>). EAE was induced by transferring myelin basic protein activated T-cells intravenously into rats. On day 4, the brain and spinal cord was excised 30 min after injection of MB<sub>ICAM-1.</sub> Registration of acoustic counts during the first scan of the brain and the spinal cord revealed a significant higher ICAM-1 expression in AT-EAE rats (P <0.001, n = 6) that received MB<sub>ICAM-1</sub> (~10,000-15,000 acoustic counts) than AT-EAE rats (n = 4) that received unspecific MB<sub>iso</sub> (~500 acoustic counts). In addition, only a marginal signal was detected in healthy controls (n = 4, ~500 acoustic counts) that received MB<sub>ICAM-1</sub>. Pretreatment of EAE rats with anti-ICAM-1 antibody or methylprednisolone (a therapeutic drug) before MB<sub>ICAM-1</sub> injection decreased the acoustic counts by >75%. The whole brain scan of living anesthetized rats after injection of MB<sub>ICAM-1</sub> confirmed the ex-vivo experiments that healthy control rats (n = 3) showed only a marginal acoustic signal, whereas EAE rats (n = 3) exhibited a strong acoustic signal similar to the ex-vivo EAE brain.</p></div><div id="MB-ICAM-1.Other_NonPrimate_Mammals"><h3>Other Non-Primate Mammals</h3><p>[<a href="/entrez/query.fcgi?cmd=PureSearch&db=pubmed&details_term=Microbubbles%20and%20ICAM-1%20and%20%28dog%20or%20pig%20or%20sheep%20or%20rabbit%29" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">PubMed</a>]</p><p>No publication is currently available.</p></div><div id="MB-ICAM-1.NonHuman_Primates"><h3>Non-Human Primates</h3><p>[<a href="/entrez/query.fcgi?cmd=PureSearch&db=pubmed&details_term=Microbubbles%20and%20ICAM-1%20and%20%28primate%20not%20human%29" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">PubMed</a>]</p><p>No publication is currently available.</p></div></div><div id="MB-ICAM-1.Human_Studies"><h2 id="_MB-ICAM-1_Human_Studies_">Human Studies</h2><p>[<a href="/entrez/query.fcgi?cmd=PureSearch&db=pubmed&details_term=Microbubbles%20and%20ICAM-1%20and%20human" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">PubMed</a>]</p><p>No publication is currently available.</p></div><div id="MB-ICAM-1.NIH_Support"><h2 id="_MB-ICAM-1_NIH_Support_">NIH Support</h2><p>HL58865</p></div><div id="MB-ICAM-1.References"><h2 id="_MB-ICAM-1_References_">References</h2><dl class="temp-labeled-list"><dl class="bkr_refwrap"><dt>1.</dt><dd><div class="bk_ref" id="MB-ICAM-1.REF.1">Wells P.N.
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<em>Physics and engineering: milestones in medicine.</em>
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<span><span class="ref-journal">Med Eng Phys. </span>2001;<span class="ref-vol">23</span>(3):147–53.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/11410379" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 11410379</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>2.</dt><dd><div class="bk_ref" id="MB-ICAM-1.REF.2">Liang H.D., Blomley M.J.
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<em>The role of ultrasound in molecular imaging.</em>
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<span><span class="ref-journal">Br J Radiol. </span>2003;<span class="ref-vol">76</span>(Spec No 2):S140–50.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/15572336" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 15572336</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>3.</dt><dd><div class="bk_ref" id="MB-ICAM-1.REF.3">Klibanov A.L.
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<em>Ligand-carrying gas-filled microbubbles: ultrasound contrast agents for targeted molecular imaging.</em>
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<span><span class="ref-journal">Bioconjug Chem. </span>2005;<span class="ref-vol">16</span>(1):9–17.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/15656569" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 15656569</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>4.</dt><dd><div class="bk_ref" id="MB-ICAM-1.REF.4">Lindner J.R.
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<em>Microbubbles in medical imaging: current applications and future directions.</em>
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<span><span class="ref-journal">Nat Rev Drug Discov. </span>2004;<span class="ref-vol">3</span>(6):527–32.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/15173842" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 15173842</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>5.</dt><dd><div class="bk_ref" id="MB-ICAM-1.REF.5">Villanueva F.S., Wagner W.R., Vannan M.A., Narula J.
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<em>Targeted ultrasound imaging using microbubbles.</em>
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<span><span class="ref-journal">Cardiol Clin. </span>2004;<span class="ref-vol">22</span>(2):283–98.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/15158940" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 15158940</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>6.</dt><dd><div class="bk_ref" id="MB-ICAM-1.REF.6">Dijkmans P.A., Juffermans L.J., Musters R.J., van Wamel A., ten Cate F.J., van Gilst W., Visser C.A., de Jong N., Kamp O.
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<em>Microbubbles and ultrasound: from diagnosis to therapy.</em>
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<span><span class="ref-journal">Eur J Echocardiogr. </span>2004;<span class="ref-vol">5</span>(4):245–56.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/15219539" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 15219539</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>7.</dt><dd><div class="bk_ref" id="MB-ICAM-1.REF.7">Cybulsky M.I., Gimbrone M.A. Jr.
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<em>Endothelial expression of a mononuclear leukocyte adhesion molecule during atherogenesis.</em>
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<span><span class="ref-journal">Science. </span>1991;<span class="ref-vol">251</span>(4995):788–91.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/1990440" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 1990440</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>8.</dt><dd><div class="bk_ref" id="MB-ICAM-1.REF.8">Lowe J.B.
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<em>Glycosylation in the control of selectin counter-receptor structure and function.</em>
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<span><span class="ref-journal">Immunol Rev. </span>2002;<span class="ref-vol">186</span>:19–36.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/12234359" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 12234359</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>9.</dt><dd><div class="bk_ref" id="MB-ICAM-1.REF.9">Vanderslice P., Woodside D.G.
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<em>Integrin antagonists as therapeutics for inflammatory diseases.</em>
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<span><span class="ref-journal">Expert Opin Investig Drugs. </span>2006;<span class="ref-vol">15</span>(10):1235–55.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/16989599" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 16989599</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>10.</dt><dd><div class="bk_ref" id="MB-ICAM-1.REF.10">Bochner B.S., Luscinskas F.W., Gimbrone M.A. Jr, Newman W., Sterbinsky S.A., Derse-Anthony C.P., Klunk D., Schleimer R.P.
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<em>Adhesion of human basophils, eosinophils, and neutrophils to interleukin 1-activated human vascular endothelial cells: contributions of endothelial cell adhesion molecules.</em>
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<span><span class="ref-journal">J Exp Med. </span>1991;<span class="ref-vol">173</span>(6):1553–7.</span> [<a href="/pmc/articles/PMC2190849/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC2190849</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/1709678" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 1709678</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>11.</dt><dd><div class="bk_ref" id="MB-ICAM-1.REF.11">Kume N., Cybulsky M.I., Gimbrone M.A. Jr.
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<em>Lysophosphatidylcholine, a component of atherogenic lipoproteins, induces mononuclear leukocyte adhesion molecules in cultured human and rabbit arterial endothelial cells.</em>
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<span><span class="ref-journal">J Clin Invest. </span>1992;<span class="ref-vol">90</span>(3):1138–44.</span> [<a href="/pmc/articles/PMC329976/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC329976</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/1381720" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 1381720</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>12.</dt><dd><div class="bk_ref" id="MB-ICAM-1.REF.12">Leung K.H.
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<em>Release of soluble ICAM-1 from human lung fibroblasts, aortic smooth muscle cells, dermal microvascular endothelial cells, bronchial epithelial cells, and keratinocytes.</em>
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<span><span class="ref-journal">Biochem Biophys Res Commun. </span>1999;<span class="ref-vol">260</span>(3):734–9.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/10403835" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 10403835</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>13.</dt><dd><div class="bk_ref" id="MB-ICAM-1.REF.13">Luscinskas F.W., Cybulsky M.I., Kiely J.M., Peckins C.S., Davis V.M., Gimbrone M.A. Jr.
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<em>Cytokine-activated human endothelial monolayers support enhanced neutrophil transmigration via a mechanism involving both endothelial-leukocyte adhesion molecule-1 and intercellular adhesion molecule-1.</em>
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<span><span class="ref-journal">J Immunol. </span>1991;<span class="ref-vol">146</span>(5):1617–25.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/1704400" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 1704400</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>14.</dt><dd><div class="bk_ref" id="MB-ICAM-1.REF.14">Nagel T., Resnick N., Atkinson W.J., Dewey C.F. Jr, Gimbrone M.A. Jr.
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<em>Shear stress selectively upregulates intercellular adhesion molecule-1 expression in cultured human vascular endothelial cells.</em>
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<span><span class="ref-journal">J Clin Invest. </span>1994;<span class="ref-vol">94</span>(2):885–91.</span> [<a href="/pmc/articles/PMC296171/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC296171</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/7518844" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 7518844</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>15.</dt><dd><div class="bk_ref" id="MB-ICAM-1.REF.15">Villanueva F.S., Jankowski R.J., Klibanov S., Pina M.L., Alber S.M., Watkins S.C., Brandenburger G.H., Wagner W.R.
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<em>Microbubbles targeted to intercellular adhesion molecule-1 bind to activated coronary artery endothelial cells.</em>
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<span><span class="ref-journal">Circulation. </span>1998;<span class="ref-vol">98</span>(1):1–5.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/9665051" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 9665051</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>16.</dt><dd><div class="bk_ref" id="MB-ICAM-1.REF.16">Weller G.E., Lu E., Csikari M.M., Klibanov A.L., Fischer D., Wagner W.R., Villanueva F.S.
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<em>Ultrasound imaging of acute cardiac transplant rejection with microbubbles targeted to intercellular adhesion molecule-1.</em>
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<span><span class="ref-journal">Circulation. </span>2003;<span class="ref-vol">108</span>(2):218–24.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/12835214" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 12835214</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>17.</dt><dd><div class="bk_ref" id="MB-ICAM-1.REF.17">Weller G.E., Villanueva F.S., Klibanov A.L., Wagner W.R.
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<em>Modulating targeted adhesion of an ultrasound contrast agent to dysfunctional endothelium.</em>
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<span><span class="ref-journal">Ann Biomed Eng. </span>2002;<span class="ref-vol">30</span>(8):1012–9.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/12449762" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 12449762</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>18.</dt><dd><div class="bk_ref" id="MB-ICAM-1.REF.18">Reinhardt M., Hauff P., Linker R.A., Briel A., Gold R., Rieckmann P., Becker G., Toyka K.V., Maurer M., Schirner M.
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<em>Ultrasound derived imaging and quantification of cell adhesion molecules in experimental autoimmune encephalomyelitis (EAE) by Sensitive Particle Acoustic Quantification (SPAQ).</em>
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<span><span class="ref-journal">Neuroimage. </span>2005;<span class="ref-vol">27</span>(2):267–78.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/15905104" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 15905104</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>19.</dt><dd><div class="bk_ref" id="MB-ICAM-1.REF.19">Weller G.E., Villanueva F.S., Tom E.M., Wagner W.R.
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<em>Targeted ultrasound contrast agents: in vitro assessment of endothelial dysfunction and multi-targeting to ICAM-1 and sialyl Lewisx.</em>
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<span><span class="ref-journal">Biotechnol Bioeng. </span>2005;<span class="ref-vol">92</span>(6):780–8.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/16121392" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 16121392</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>20.</dt><dd><div class="bk_ref" id="MB-ICAM-1.REF.20">Reinhardt M., Hauff P., Briel A., Uhlendorf V., Linker R.A., Maurer M., Schirner M.
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<em>Sensitive particle acoustic quantification (SPAQ): a new ultrasound-based approach for the quantification of ultrasound contrast media in high concentrations.</em>
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<span><span class="ref-journal">Invest Radiol. </span>2005;<span class="ref-vol">40</span>(1):2–7.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/15597013" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 15597013</span></a>]</div></dd></dl></dl></div><div id="bk_toc_contnr"></div></div></div><div class="fm-sec"><h2 id="_NBK24611_pubdet_">Publication Details</h2><h3>Author Information and Affiliations</h3><div class="contrib half_rhythm"><span itemprop="author">Kam Leung</span>, PhD<div class="affiliation small">National Center for Biotechnology Information, NLM, NIH, Bethesda, MD<div><span class="email-label">Email: </span><a href="mailto:dev@null" data-email="vog.hin.mln.ibcn@DACIM" class="oemail">vog.hin.mln.ibcn@DACIM</a></div></div><div class="small">Corresponding author.</div></div><h3>Publication History</h3><p class="small">Created: <span itemprop="datePublished">December 21, 2006</span>; Last Update: <span itemprop="dateModified">April 17, 2012</span>.</p><h3>Copyright</h3><div><div class="half_rhythm"><a href="/books/about/copyright/">Copyright Notice</a></div></div><h3>Publisher</h3><p><a href="http://www.ncbi.nlm.nih.gov/" ref="pagearea=page-banner&targetsite=external&targetcat=link&targettype=publisher">National Center for Biotechnology Information (US)</a>, Bethesda (MD)</p><h3>NLM Citation</h3><p>Leung K. Microbubbles coated with antibody to intracellular adhesion molecule-1. 2006 Dec 21 [Updated 2012 Apr 17]. In: Molecular Imaging and Contrast Agent Database (MICAD) [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2004-2013. <span class="bk_cite_avail"></span></p></div><div class="small-screen-prev"><a href="/books/n/micad/VEGFR2MB/?report=reader"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 100 100" preserveAspectRatio="none"><path d="M75,30 c-80,60 -80,0 0,60 c-30,-60 -30,0 0,-60"></path><text x="20" y="28" textLength="60" style="font-size:25px">Prev</text></svg></a></div><div class="small-screen-next"><a href="/books/n/micad/MB-MAdCAM-1/?report=reader"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 100 100" preserveAspectRatio="none"><path d="M25,30c80,60 80,0 0,60 c30,-60 30,0 0,-60"></path><text x="20" y="28" textLength="60" style="font-size:25px">Next</text></svg></a></div></article><article data-type="table-wrap" id="figobMBICAM1Tncchemicalnamemicrobubbles"><div id="MB-ICAM-1.T.nc_chemical_namemicrobubbles" class="table"><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK24611/table/MB-ICAM-1.T.nc_chemical_namemicrobubbles/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__MB-ICAM-1.T.nc_chemical_namemicrobubbles_lrgtbl__"><table><tbody><tr><td rowspan="1" colspan="1" style="text-align:right;vertical-align:top;">
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<b>Chemical name:</b>
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</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Microbubbles coated with antibody to intracellular adhesion molecule-1</td><td rowspan="9" colspan="1" style="text-align:center;vertical-align:middle;"></td></tr><tr><td rowspan="1" colspan="1" style="text-align:right;vertical-align:top;">
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<b>Abbreviated name:</b>
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</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">MB<sub>ICAM-1</sub></td></tr><tr><td rowspan="1" colspan="1" style="text-align:right;vertical-align:top;">
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<b>Synonym:</b>
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</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td></tr><tr><td rowspan="1" colspan="1" style="text-align:right;vertical-align:top;">
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<b>Agent category:</b>
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</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Antibody</td></tr><tr><td rowspan="1" colspan="1" style="text-align:right;vertical-align:top;">
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<b>Target:</b>
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</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Intracellular adhesion molecule-1 (ICAM-1)</td></tr><tr><td rowspan="1" colspan="1" style="text-align:right;vertical-align:top;">
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<b>Target category:</b>
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</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Adhesion molecule</td></tr><tr><td rowspan="1" colspan="1" style="text-align:right;vertical-align:top;">
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<b>Method of detection:</b>
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</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Ultrasound (US)</td></tr><tr><td rowspan="1" colspan="1" style="text-align:right;vertical-align:top;">
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<b>Source of signal:</b>
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</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Microbubbles</td></tr><tr><td rowspan="1" colspan="1" style="text-align:right;vertical-align:top;">
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<b>Activation:</b>
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</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">No</td></tr><tr><td rowspan="1" colspan="1" style="text-align:right;vertical-align:top;">
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<b>Studies:</b>
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</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<ul class="simple-list"><li class="half_rhythm"><div>
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<img alt="Checkbox" src="/corehtml/pmc/css/bookshelf/2.26/img/studies.checkbox.png" />
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<i>In vitro</i>
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</div></li><li class="half_rhythm"><div>
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<img alt="Checkbox" src="/corehtml/pmc/css/bookshelf/2.26/img/studies.checkbox.png" /> Rodents
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</div></li></ul>
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</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Click on <a href="/entrez/viewer.fcgi?db=protein&val=825682" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">protein</a>, <a href="/entrez/viewer.fcgi?db=nucleotide&val=4557877" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">nucleotide</a> (RefSeq), and <a href="/entrez/query.fcgi?db=gene&cmd=Retrieve&dopt=full_report&list_uids=3383" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">gene</a> for more information about ICAM-1.</td></tr></tbody></table></div></div></article></div><div id="jr-scripts"><script src="/corehtml/pmc/jatsreader/ptpmc_3.22/js/libs.min.js"> </script><script src="/corehtml/pmc/jatsreader/ptpmc_3.22/js/jr.min.js"> </script></div></div>
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