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<script type="text/javascript" src="/corehtml/pmc/jatsreader/ptpmc_3.22/js/jr.boots.min.js"> </script><title>99mTc-Hydrazinonicotinamide-epidermal growth factor - Molecular Imaging and Contrast Agent Database (MICAD) - NCBI Bookshelf</title>
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<meta name="citation_title" content="99mTc-Hydrazinonicotinamide-epidermal growth factor">
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<meta name="citation_date" content="2012/01/11">
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<meta name="citation_author" content="Kam Leung">
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<meta name="description" content="Epidermal growth factor (EGF) is a 53-amino acid cytokine (6.2 kDa) secreted by ectodermic cells, monocytes, kidneys and duodenal glands (1). EGF stimulates growth of epidermal and epithelial cells. EGF receptor (EGFR) is a transmembrane protein with an intracellular tyrosine kinase present on most cells. EGFR is overexpressed on many solid tumor cells, such as those of breast, non-small-cell lung, head and neck, and colon cancers (2-4). The high level of EGFR expression on cancer cells is associated with a poor prognosis (5-7). EGF has been labeled with 99mTc by various laboratories as a potential SPECT imaging agent for EGFR expression on cancer cells (8-11).">
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<meta name="og:description" content="Epidermal growth factor (EGF) is a 53-amino acid cytokine (6.2 kDa) secreted by ectodermic cells, monocytes, kidneys and duodenal glands (1). EGF stimulates growth of epidermal and epithelial cells. EGF receptor (EGFR) is a transmembrane protein with an intracellular tyrosine kinase present on most cells. EGFR is overexpressed on many solid tumor cells, such as those of breast, non-small-cell lung, head and neck, and colon cancers (2-4). The high level of EGFR expression on cancer cells is associated with a poor prognosis (5-7). EGF has been labeled with 99mTc by various laboratories as a potential SPECT imaging agent for EGFR expression on cancer cells (8-11).">
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id="jr-fip-info-p"><a id="jr-fip-prev" class="wsprkl btn" title="Jump to previuos match">◀</a><button id="jr-fip-matches">no matches yet</button><a id="jr-fip-next" class="wsprkl btn" title="Jump to next match">▶</a></nav></nav></div><div id="jr-epub-interstitial" class="hidden"></div><div id="jr-content"><article data-type="main"><div class="main-content lit-style" itemscope="itemscope" itemtype="http://schema.org/CreativeWork"><div class="meta-content fm-sec"><div class="fm-sec"><h1 id="_NBK23264_"><span class="title" itemprop="name"><sup>99m</sup>Tc-Hydrazinonicotinamide-epidermal growth factor</span></h1><div itemprop="alternativeHeadline" class="subtitle whole_rhythm"><sup>99m</sup>Tc-HYNIC-EGF</div><p class="contribs">Leung K.</p><p class="fm-aai"><a href="#_NBK23264_pubdet_">Publication Details</a></p></div></div><div class="jig-ncbiinpagenav body-content whole_rhythm" data-jigconfig="allHeadingLevels: ['h2'],smoothScroll: false" itemprop="text"><div class="iconblock whole_rhythm clearfix ten_col table-wrap" id="figHYNICEGF99mTcTncchemicalname99mtch"><a href="/books/NBK23264/table/HYNIC-EGF-99mTc.T.nc_chemical_name99mtch/?report=objectonly" target="object" title="Table" class="img_link icnblk_img" rid-ob="figobHYNICEGF99mTcTncchemicalname99mtch"><img class="small-thumb" src="/corehtml/pmc/css/bookshelf/2.26/img/table-icon.gif" alt="Table Icon" /></a><div class="icnblk_cntnt"><h4 id="HYNIC-EGF-99mTc.T.nc_chemical_name99mtch"><a href="/books/NBK23264/table/HYNIC-EGF-99mTc.T.nc_chemical_name99mtch/?report=objectonly" target="object" rid-ob="figobHYNICEGF99mTcTncchemicalname99mtch">Table</a></h4><p class="float-caption no_bottom_margin">
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<i>In vitro</i>
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Rodents
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</p></div></div><div id="HYNIC-EGF-99mTc.Background"><h2 id="_HYNIC-EGF-99mTc_Background_">Background</h2><p>[<a href="/entrez/query.fcgi?cmd=PureSearch&db=pubmed&details_term=99mTc%5BAll%20Fields%5D%20AND%20EGF%5BAll%20Fields%5D" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">PubMed</a>]</p><p>Epidermal growth factor (EGF) is a 53-amino acid cytokine (6.2 kDa) secreted by ectodermic cells, monocytes, kidneys and duodenal glands (<a class="bibr" href="#HYNIC-EGF-99mTc.REF.1" rid="HYNIC-EGF-99mTc.REF.1">1</a>). EGF stimulates growth of epidermal and epithelial cells. EGF receptor (EGFR) is a transmembrane protein with an intracellular tyrosine kinase present on most cells. EGFR is overexpressed on many solid tumor cells, such as those of breast, non-small-cell lung, head and neck, and colon cancers (<a class="bibr" href="#HYNIC-EGF-99mTc.REF.2" rid="HYNIC-EGF-99mTc.REF.2 HYNIC-EGF-99mTc.REF.3 HYNIC-EGF-99mTc.REF.4">2-4</a>). The high level of EGFR expression on cancer cells is associated with a poor prognosis (<a class="bibr" href="#HYNIC-EGF-99mTc.REF.5" rid="HYNIC-EGF-99mTc.REF.5 HYNIC-EGF-99mTc.REF.6 HYNIC-EGF-99mTc.REF.7">5-7</a>). EGF has been labeled with <sup>99m</sup>Tc by various laboratories as a potential SPECT imaging agent for EGFR expression on cancer cells (<a class="bibr" href="#HYNIC-EGF-99mTc.REF.8" rid="HYNIC-EGF-99mTc.REF.8 HYNIC-EGF-99mTc.REF.9 HYNIC-EGF-99mTc.REF.10 HYNIC-EGF-99mTc.REF.11">8-11</a>).</p><p>The Ras protein is a key regulator in the signaling pathway of the EGFR. Inhibition of farnesylation of Ras in cancer cells by farnesyltransferase inhibitors (FTI) led to inhibition of tumor growth, up regulation of EGFR, and decreased internalization of EGFR (<a class="bibr" href="#HYNIC-EGF-99mTc.REF.12" rid="HYNIC-EGF-99mTc.REF.12">12</a>). <sup>99m</sup>Tc-HYNIC-EGF was developed for in vivo prediction of cancer cell response to FTI (<a class="bibr" href="#HYNIC-EGF-99mTc.REF.8" rid="HYNIC-EGF-99mTc.REF.8">8</a>).</p><div id="HYNIC-EGF-99mTc.Related_Resource_Links"><h3>Related Resource Links:</h3><ul><li class="half_rhythm"><div>Chapters in MICAD (<a href="/books?term=EGFR%5BAll%20Fields%5D%20AND%20micad%5Bbook%5D" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">EGFR</a>)</div></li><li class="half_rhythm"><div>Gene information in NCBI (<a href="/gene/1950" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">EGF</a>, <a href="/gene/1956" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">EGFR</a>).</div></li><li class="half_rhythm"><div>Articles in Online Mendelian Inheritance in Man (OMIM) (<a href="/omim/131530" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">EGF</a>, <a href="/omim/131550" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">EGFR</a>)</div></li><li class="half_rhythm"><div>Clinical trials (<a href="http://www.clinicaltrials.gov/ct2/results?term=EGF" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">EGF</a>)</div></li><li class="half_rhythm"><div>Drug information in FDA (<a href="http://google2.fda.gov/search?q=EGF&client=FDAgov&site=FDAgov&lr=&proxystylesheet=FDAgov&output=xml_no_dtd&getfields=*&x=6&y=9" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">EGF</a>)</div></li></ul></div></div><div id="HYNIC-EGF-99mTc.Synthesis"><h2 id="_HYNIC-EGF-99mTc_Synthesis_">Synthesis</h2><p>[<a href="/entrez/query.fcgi?cmd=PureSearch&db=pubmed&details_term=99mTc%20AND%20EGF%20AND%20synthesis" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">PubMed</a>]</p><p>Hydrazinonicotinamide (HYNIC) was conjugated to human EGF to form HYNIC-EGF, which was purified by dialysis with a yield of >94% (<a class="bibr" href="#HYNIC-EGF-99mTc.REF.8" rid="HYNIC-EGF-99mTc.REF.8">8</a>). A mixture of HYNIC-EGF and [<sup>99m</sup>Tc]pertechnetate (74–370 MBq, 2–10 mCi) in reaction solution was incubated at room temperature for 20 min. <sup>99m</sup>Tc-HYNIC-EGF was purified by column chromatography to yield 81-95%, with a radiochemical purity of >95%. The specific activity of <sup>99m</sup>Tc-HYNIC-EGF was 1.23 Bq/nmol (33 pCi/nmol) for <i>in vitro</i> binding studies and 3.7–7.4 MBq/nmol (0.1–0.2 mCi/nmol) for the biodistribution studies.</p></div><div id="HYNIC-EGF-99mTc.In_Vitro_Studies_Testing"><h2 id="_HYNIC-EGF-99mTc_In_Vitro_Studies_Testing_"><i>In Vitro</i> Studies: Testing in Cells and Tissues</h2><p>[<a href="/entrez/query.fcgi?cmd=PureSearch&db=pubmed&details_term=99mTc%20AND%20EGF%20AND%20in%20vitro" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">PubMed</a>]</p><p><sup>99m</sup>Tc-HYNIC-EGF was found to be stable in Ham’s F12 cell growth medium at 25ºC up to 4 h (<a class="bibr" href="#HYNIC-EGF-99mTc.REF.8" rid="HYNIC-EGF-99mTc.REF.8">8</a>). LoVo human colon adenocarcinoma cells showed a <i>K</i><sub>d</sub> of 3.6 nM with <sup>99m</sup>Tc-HYNIC-EGF and 4.0 nM with [<sup>125</sup>I]EGF in saturation binding studies (<a class="bibr" href="#HYNIC-EGF-99mTc.REF.8" rid="HYNIC-EGF-99mTc.REF.8 HYNIC-EGF-99mTc.REF.13">8, 13</a>). MAb88910 is a monoclonal antibody that inhibits EGF binding to EGFR. MAb88910 showed a <i>K</i><sub>i</sub> value of 1.7 nM and 1.3 nM for blocking <sup>99m</sup>Tc-HYNIC-EGF and [<sup>125</sup>I]EGF binding to LoVo cells, respectively (<a class="bibr" href="#HYNIC-EGF-99mTc.REF.8" rid="HYNIC-EGF-99mTc.REF.8 HYNIC-EGF-99mTc.REF.13">8, 13</a>).</p></div><div id="HYNIC-EGF-99mTc.Animal_Studies"><h2 id="_HYNIC-EGF-99mTc_Animal_Studies_">Animal Studies</h2><div id="HYNIC-EGF-99mTc.Rodents"><h3>Rodents</h3><p>[<a href="/entrez/query.fcgi?cmd=PureSearch&db=pubmed&details_term=99mTc%20HYNIC%5BAll%20Fields%5D%20AND%20EGF%20and%20rodentia" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">PubMed</a>]</p><p>Normal mice were injected with injected i.v. with <sup>99m</sup>Tc-HYNIC-EGF (0.555 MBq, 0.015 mCi, 1 μg or 0.15 nmol) (<a class="bibr" href="#HYNIC-EGF-99mTc.REF.8" rid="HYNIC-EGF-99mTc.REF.8">8</a>). The liver (55.0 ± 11.2% injected dose (ID)/g at 40 min) and kidneys (31.9 ± 18.4% ID/g at 5 min) were the major organs of uptake. A small amount was taken up by the small intestine (4.3 ± 1.8% ID/g at 2 h) and large intestine (7.7 ± 1.9% ID/g at 6 h) at later time points. Stomach activity was significantly higher than blood, beginning 20 min after injection. There was also some uptake in the spleen, which is maximal at 10 min after injection. After 48 h, only 52% of the injected <sup>99m</sup>Tc-HYNIC-EGF was excreted, whereas the remaining radioactivity was in the liver, kidneys, and spleen.</p><p><sup>99m</sup>Tc-HYNIC-hEGF was taken up in LoVo tumor tissue in tumor-bearing athymic mice (<a class="bibr" href="#HYNIC-EGF-99mTc.REF.8" rid="HYNIC-EGF-99mTc.REF.8">8</a>). The tumor-to-thigh ratio was maximal at 2 h (2.5 ± 0.8). The nominal value of the uptake at 2 h was 3.5 ± 1.2%ID/g. Blocking with MAb88910 resulted in a decrease of the ratio from 2.5±0.8 to 1.2±0.2 (<i>p</i><0.01). Co-injection of 100 μg of unlabelled EGF decreased the ratio to 1.1 ± 0.3 (<i>p</i><0.01). In both cases, the muscle uptake did not change significantly. When comparing <sup>99m</sup>Tc-HYNIC-EGF tumor uptake data to <sup>123</sup>I-EGF values, no significant differences were seen. Both tracers showed a maximum tumor-to-thigh ratio at 2 h (<sup>123</sup>I-EGF uptake ratio at 2 h was 2.0 ± 0.3). Pretreatment of tumor-bearing mice with FTI inhibitor (R115777, 100 mg/kg) for 6-8 h before <sup>99m</sup>Tc-HYNIC-EGF injection decreased the tumor-to-muscle ratio from 2.5 to 1.0. Similar results were also obtained using planar gamma scintigraphy imaging. The control experiment using <sup>99m</sup>Tc-HSA showed that the effect of FTI inhibition was not due to an influence on vascularization (<a class="bibr" href="#HYNIC-EGF-99mTc.REF.13" rid="HYNIC-EGF-99mTc.REF.13">13</a>).</p></div><div id="HYNIC-EGF-99mTc.Other_NonPrimate_Mammals"><h3>Other Non-Primate Mammals</h3><p>[<a href="/entrez/query.fcgi?cmd=PureSearch&db=pubmed&details_term=99mTc%20HYNIC%5BAll%20Fields%5D%20AND%20EGF%20and%20%28dog%20or%20pig%20or%20sheep%20or%20rabbit%29" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">PubMed</a>]</p><p>No publication is currently available.</p></div><div id="HYNIC-EGF-99mTc.NonHuman_Primates"><h3>Non-Human Primates</h3><p>[<a href="/entrez/query.fcgi?cmd=PureSearch&db=pubmed&details_term=99mTc%20HYNIC%20AND%20EGF%20and%20%28primates%20not%20humans%29" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">PubMed</a>]</p><p>No publication is currently available</p></div></div><div id="HYNIC-EGF-99mTc.Human_Studies"><h2 id="_HYNIC-EGF-99mTc_Human_Studies_">Human Studies</h2><p>[<a href="/entrez/query.fcgi?cmd=PureSearch&db=pubmed&details_term=99mTc%20HYNIC%20AND%20EGF%20and%20humans" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">PubMed</a>]</p><p>No publication is currently available.</p></div><div id="HYNIC-EGF-99mTc.References"><h2 id="_HYNIC-EGF-99mTc_References_">References</h2><dl class="temp-labeled-list"><dl class="bkr_refwrap"><dt>1.</dt><dd><div class="bk_ref" id="HYNIC-EGF-99mTc.REF.1">Carpenter G., Cohen S.
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<em>Epidermal growth factor.</em>
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<span><span class="ref-journal">J Biol Chem. </span>1990;<span class="ref-vol">265</span>(14):7709–12.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/2186024" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 2186024</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>2.</dt><dd><div class="bk_ref" id="HYNIC-EGF-99mTc.REF.2">Grunwald V., Hidalgo M.
|
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<em>Developing inhibitors of the epidermal growth factor receptor for cancer treatment.</em>
|
|
<span><span class="ref-journal">J Natl Cancer Inst. </span>2003;<span class="ref-vol">95</span>(12):851–67.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/12813169" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 12813169</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>3.</dt><dd><div class="bk_ref" id="HYNIC-EGF-99mTc.REF.3">Mendelsohn J.
|
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<em>Anti-epidermal growth factor receptor monoclonal antibodies as potential anti-cancer agents.</em>
|
|
<span><span class="ref-journal">J Steroid Biochem Mol Biol. </span>1990;<span class="ref-vol">37</span>(6):889–92.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/2285602" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 2285602</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>4.</dt><dd><div class="bk_ref" id="HYNIC-EGF-99mTc.REF.4">Yasui W., Sumiyoshi H., Hata J., Kameda T., Ochiai A., Ito H., Tahara E.
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<em>Expression of epidermal growth factor receptor in human gastric and colonic carcinomas.</em>
|
|
<span><span class="ref-journal">Cancer Res. </span>1988;<span class="ref-vol">48</span>(1):137–41.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/2446740" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 2446740</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>5.</dt><dd><div class="bk_ref" id="HYNIC-EGF-99mTc.REF.5">Ang K.K., Berkey B.A., Tu X., Zhang H.Z., Katz R., Hammond E.H., Fu K.K., Milas L.
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<em>Impact of epidermal growth factor receptor expression on survival and pattern of relapse in patients with advanced head and neck carcinoma.</em>
|
|
<span><span class="ref-journal">Cancer Res. </span>2002;<span class="ref-vol">62</span>(24):7350–6.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/12499279" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 12499279</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>6.</dt><dd><div class="bk_ref" id="HYNIC-EGF-99mTc.REF.6">Costa S., Stamm H., Almendral A., Ludwig H., Wyss R., Fabbro D., Ernst A., Takahashi A., Eppenberger U.
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<em>Predictive value of EGF receptor in breast cancer.</em>
|
|
<span><span class="ref-journal">Lancet. </span>1988;<span class="ref-vol">2</span>(8622):1258.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/2903994" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 2903994</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>7.</dt><dd><div class="bk_ref" id="HYNIC-EGF-99mTc.REF.7">Ethier S.P.
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<em>Growth factor synthesis and human breast cancer progression.</em>
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<span><span class="ref-journal">J Natl Cancer Inst. </span>1995;<span class="ref-vol">87</span>(13):964–73.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/7629883" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 7629883</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>8.</dt><dd><div class="bk_ref" id="HYNIC-EGF-99mTc.REF.8">Cornelissen B., Kersemans V., Burvenich I., Oltenfreiter R., Vanderheyden J.L., Boerman O., Vandewiele C., Slegers G.
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<em>Synthesis, biodistribution and effects of farnesyltransferase inhibitor therapy on tumour uptake in mice of 99mTc labelled epidermal growth factor.</em>
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<span><span class="ref-journal">Nucl Med Commun. </span>2005;<span class="ref-vol">26</span>(2):147–53.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/15657509" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 15657509</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>9.</dt><dd><div class="bk_ref" id="HYNIC-EGF-99mTc.REF.9">Rusckowski M., Qu T., Chang F., Hnatowich D.J.
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<em>Technetium-99m labeled epidermal growth factor-tumor imaging in mice.</em>
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<span><span class="ref-journal">J Pept Res. </span>1997;<span class="ref-vol">50</span>(5):393–401.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/9401925" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 9401925</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>10.</dt><dd><div class="bk_ref" id="HYNIC-EGF-99mTc.REF.10">Yang W., Barth R.F., Leveille R., Adams D.M., Ciesielski M., Fenstermaker R.A., Capala J.
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<em>Evaluation of systemically administered radiolabeled epidermal growth factor as a brain tumor targeting agent.</em>
|
|
<span><span class="ref-journal">J Neurooncol. </span>2001;<span class="ref-vol">55</span>(1):19–28.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/11804279" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 11804279</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>11.</dt><dd><div class="bk_ref" id="HYNIC-EGF-99mTc.REF.11">Capala J., Barth R.F., Bailey M.Q., Fenstermaker R.A., Marek M.J., Rhodes B.A.
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<em>Radiolabeling of epidermal growth factor with 99mTc and in vivo localization following intracerebral injection into normal and glioma-bearing rats.</em>
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<span><span class="ref-journal">Bioconjug Chem. </span>1997;<span class="ref-vol">8</span>(3):289–95.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/9177833" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 9177833</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>12.</dt><dd><div class="bk_ref" id="HYNIC-EGF-99mTc.REF.12">End D.W., Smets G., Todd A.V., Applegate T.L., Fuery C.J., Angibaud P., Venet M., Sanz G., Poignet H., Skrzat S., Devine A., Wouters W., Bowden C.
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<em>Characterization of the antitumor effects of the selective farnesyl protein transferase inhibitor R115777 in vivo and in vitro.</em>
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<span><span class="ref-journal">Cancer Res. </span>2001;<span class="ref-vol">61</span>(1):131–7.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/11196150" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 11196150</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>13.</dt><dd><div class="bk_ref" id="HYNIC-EGF-99mTc.REF.13">Cornelissen B., Thonissen T., Kersemans V., Van De Wiele C., Lahorte C., Dierckx R.A., Slegers G.
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<em>Influence of farnesyl transferase inhibitor treatment on epidermal growth factor receptor status.</em>
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<span><span class="ref-journal">Nucl Med Biol. </span>2004;<span class="ref-vol">31</span>(6):679–89.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/15246358" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 15246358</span></a>]</div></dd></dl></dl></div><div id="bk_toc_contnr"></div></div></div><div class="fm-sec"><h2 id="_NBK23264_pubdet_">Publication Details</h2><h3>Author Information and Affiliations</h3><div class="contrib half_rhythm"><span itemprop="author">Kam Leung</span>, PhD<div class="affiliation small">National Center for Biotechnology Information, NLM, NIH, Bethesda, MD<div><span class="email-label">Email: </span><a href="mailto:dev@null" data-email="vog.hin.mln.ibcn@dacim" class="oemail">vog.hin.mln.ibcn@dacim</a></div></div><div class="small">Corresponding author.</div></div><h3>Publication History</h3><p class="small">Created: <span itemprop="datePublished">June 3, 2005</span>; Last Update: <span itemprop="dateModified">January 11, 2012</span>.</p><h3>Copyright</h3><div><div class="half_rhythm"><a href="/books/about/copyright/">Copyright Notice</a></div></div><h3>Publisher</h3><p><a href="http://www.ncbi.nlm.nih.gov/" ref="pagearea=page-banner&targetsite=external&targetcat=link&targettype=publisher">National Center for Biotechnology Information (US)</a>, Bethesda (MD)</p><h3>NLM Citation</h3><p>Leung K. 99mTc-Hydrazinonicotinamide-epidermal growth factor. 2005 Jun 3 [Updated 2012 Jan 11]. In: Molecular Imaging and Contrast Agent Database (MICAD) [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2004-2013. <span class="bk_cite_avail"></span></p></div><div class="small-screen-prev"><a href="/books/n/micad/DC101-HYNIC99mTc/?report=reader"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 100 100" preserveAspectRatio="none"><path d="M75,30 c-80,60 -80,0 0,60 c-30,-60 -30,0 0,-60"></path><text x="20" y="28" textLength="60" style="font-size:25px">Prev</text></svg></a></div><div class="small-screen-next"><a href="/books/n/micad/HGC-HYNIC99mTc/?report=reader"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 100 100" preserveAspectRatio="none"><path d="M25,30c80,60 80,0 0,60 c30,-60 30,0 0,-60"></path><text x="20" y="28" textLength="60" style="font-size:25px">Next</text></svg></a></div></article><article data-type="table-wrap" id="figobHYNICEGF99mTcTncchemicalname99mtch"><div id="HYNIC-EGF-99mTc.T.nc_chemical_name99mtch" class="table"><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK23264/table/HYNIC-EGF-99mTc.T.nc_chemical_name99mtch/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__HYNIC-EGF-99mTc.T.nc_chemical_name99mtch_lrgtbl__"><table><tbody><tr><td rowspan="1" colspan="1" style="text-align:right;vertical-align:top;">
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<b>Chemical name:</b>
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</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;"><sup>99m</sup>Tc-Hydrazinonicotinamide-epidermal growth factor</td><td rowspan="9" colspan="1" style="text-align:center;vertical-align:middle;"></td></tr><tr><td rowspan="1" colspan="1" style="text-align:right;vertical-align:top;">
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<b>Abbreviated name:</b>
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</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;"><sup>99m</sup>Tc-HYNIC-EGF</td></tr><tr><td rowspan="1" colspan="1" style="text-align:right;vertical-align:top;">
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<b>Synonym:</b>
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</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;"></td></tr><tr><td rowspan="1" colspan="1" style="text-align:right;vertical-align:top;">
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<b>Agent category:</b>
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</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Polypeptide</td></tr><tr><td rowspan="1" colspan="1" style="text-align:right;vertical-align:top;">
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<b>Target:</b>
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</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Epidermal growth factor receptor (EGFR)</td></tr><tr><td rowspan="1" colspan="1" style="text-align:right;vertical-align:top;">
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<b>Target category:</b>
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</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Receptor</td></tr><tr><td rowspan="1" colspan="1" style="text-align:right;vertical-align:top;">
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<b>Method of detection:</b>
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</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Single photon emission computed tomography (SPECT)</td></tr><tr><td rowspan="1" colspan="1" style="text-align:right;vertical-align:top;">
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<b>Source of signal:</b>
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</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"><sup>99m</sup>Tc</td></tr><tr><td rowspan="1" colspan="1" style="text-align:right;vertical-align:top;">
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<b>Activation:</b>
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</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">No</td></tr><tr><td rowspan="1" colspan="1" style="text-align:right;vertical-align:top;">
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<b>Studies:</b>
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</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<ul class="simple-list"><li class="half_rhythm"><div>
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<img alt="Checkbox" src="/corehtml/pmc/css/bookshelf/2.26/img/studies.checkbox.png" />
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<i>In vitro</i>
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</div></li><li class="half_rhythm"><div>
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<img alt="Checkbox" src="/corehtml/pmc/css/bookshelf/2.26/img/studies.checkbox.png" /> Rodents
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</div></li></ul>
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</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Click on <a href="/entrez/viewer.fcgi?db=protein&val=41327732" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">protein</a>, <a href="/entrez/viewer.fcgi?val=NM_201282.1" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">nucleotide</a> (RefSeq), and <a href="/entrez/query.fcgi?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=1956" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">gene</a> for more information about EGFR.</td></tr></tbody></table></div></div></article></div><div id="jr-scripts"><script src="/corehtml/pmc/jatsreader/ptpmc_3.22/js/libs.min.js"> </script><script src="/corehtml/pmc/jatsreader/ptpmc_3.22/js/jr.min.js"> </script></div></div>
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