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<meta name="robots" content="INDEX,FOLLOW,NOARCHIVE" /><meta name="citation_inbook_title" content="Molecular Imaging and Contrast Agent Database (MICAD) [Internet]" /><meta name="citation_title" content="6-(3'-[18F]Fluoropropyl)-2-(4'-dimethylamino)phenylimidazol[1,2-α]pyridine" /><meta name="citation_publisher" content="National Center for Biotechnology Information (US)" /><meta name="citation_date" content="2008/04/09" /><meta name="citation_author" content="Kenneth T. Cheng" /><meta name="citation_pmid" content="20641285" /><meta name="citation_fulltext_html_url" content="https://www.ncbi.nlm.nih.gov/books/NBK23080/" /><link rel="schema.DC" href="http://purl.org/DC/elements/1.0/" /><meta name="DC.Title" content="6-(3'-[18F]Fluoropropyl)-2-(4'-dimethylamino)phenylimidazol[1,2-α]pyridine" /><meta name="DC.Type" content="Text" /><meta name="DC.Publisher" content="National Center for Biotechnology Information (US)" /><meta name="DC.Contributor" content="Kenneth T. Cheng" /><meta name="DC.Date" content="2008/04/09" /><meta name="DC.Identifier" content="https://www.ncbi.nlm.nih.gov/books/NBK23080/" /><meta name="description" content="6-(3'-[18F]Fluoropropyl)-2-(4'-dimethylaminophenylimidazol[1,2-α]pyridine ([18F]FPPIP) is a radioligand that was developed for positron emission tomography (PET) imaging of amyloid-β (Aβ) plaques in the central nervous system (CNS) for detection of Alzheimer’s disease (AD) (1). 18F is a positron emitter with a physical t½ of 109.7 min." /><meta name="og:title" content="6-(3'-[18F]Fluoropropyl)-2-(4'-dimethylamino)phenylimidazol[1,2-α]pyridine" /><meta name="og:type" content="book" /><meta name="og:description" content="6-(3'-[18F]Fluoropropyl)-2-(4'-dimethylaminophenylimidazol[1,2-α]pyridine ([18F]FPPIP) is a radioligand that was developed for positron emission tomography (PET) imaging of amyloid-β (Aβ) plaques in the central nervous system (CNS) for detection of Alzheimer’s disease (AD) (1). 18F is a positron emitter with a physical t½ of 109.7 min." /><meta name="og:url" content="https://www.ncbi.nlm.nih.gov/books/NBK23080/" /><meta name="og:site_name" content="NCBI Bookshelf" /><meta name="og:image" content="https://www.ncbi.nlm.nih.gov/corehtml/pmc/pmcgifs/bookshelf/thumbs/th-micad-lrg.png" /><meta name="twitter:card" content="summary" /><meta name="twitter:site" content="@ncbibooks" /><meta name="bk-non-canon-loc" content="/books/n/micad/FPPIP18F/" /><link rel="canonical" href="https://www.ncbi.nlm.nih.gov/books/NBK23080/" /><link rel="stylesheet" href="/corehtml/pmc/css/figpopup.css" type="text/css" media="screen" /><link rel="stylesheet" href="/corehtml/pmc/css/bookshelf/2.26/css/books.min.css" type="text/css" /><link rel="stylesheet" href="/corehtml/pmc/css/bookshelf/2.26/css/books_print.min.css" type="text/css" media="print" /><style type="text/css">p a.figpopup{display:inline !important} .bk_tt {font-family: monospace} .first-line-outdent .bk_ref {display: inline} .body-content h2, .body-content .h2 {border-bottom: 1px solid #97B0C8} .body-content h2.inline {border-bottom: none} a.page-toc-label , .jig-ncbismoothscroll a {text-decoration:none;border:0 !important} .temp-labeled-list .graphic {display:inline-block !important} .temp-labeled-list img{width:100%}</style><script type="text/javascript" src="/corehtml/pmc/js/jquery.hoverIntent.min.js"> </script><script type="text/javascript" src="/corehtml/pmc/js/common.min.js?_=3.18"> </script><script type="text/javascript" src="/corehtml/pmc/js/large-obj-scrollbars.min.js"> </script><script type="text/javascript">window.name="mainwindow";</script><script type="text/javascript" src="/corehtml/pmc/js/bookshelf/2.26/book-toc.min.js"> </script><script type="text/javascript" src="/corehtml/pmc/js/bookshelf/2.26/books.min.js"> </script><meta name="book-collection" content="NONE" />
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<div class="pre-content"><div><div class="bk_prnt"><p class="small">NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.</p><p>Molecular Imaging and Contrast Agent Database (MICAD) [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2004-2013. </p></div><div class="iconblock clearfix whole_rhythm no_top_margin bk_noprnt"><a class="img_link icnblk_img" title="Table of Contents Page" href="/books/n/micad/"><img class="source-thumb" src="/corehtml/pmc/pmcgifs/bookshelf/thumbs/th-micad-lrg.png" alt="Cover of Molecular Imaging and Contrast Agent Database (MICAD)" height="100px" width="80px" /></a><div class="icnblk_cntnt eight_col"><h2>Molecular Imaging and Contrast Agent Database (MICAD) [Internet].</h2><a data-jig="ncbitoggler" href="#__NBK23080_dtls__">Show details</a><div style="display:none" class="ui-widget" id="__NBK23080_dtls__"><div>Bethesda (MD): <a href="https://www.ncbi.nlm.nih.gov/" ref="pagearea=page-banner&targetsite=external&targetcat=link&targettype=publisher">National Center for Biotechnology Information (US)</a>; 2004-2013.</div></div><div class="half_rhythm"><ul class="inline_list"><li style="margin-right:1em"><a class="bk_cntns" href="/books/n/micad/">Contents</a></li></ul></div><div class="bk_noprnt"><form method="get" action="/books/n/micad/" id="bk_srch"><div class="bk_search"><label for="bk_term" class="offscreen_noflow">Search term</label><input type="text" title="Search this book" id="bk_term" name="term" value="" data-jig="ncbiclearbutton" /> <input type="submit" class="jig-ncbibutton" value="Search this book" submit="false" style="padding: 0.1em 0.4em;" /></div></form></div></div><div class="icnblk_cntnt two_col"><div class="pagination bk_noprnt"><a class="active page_link prev" href="/books/n/micad/BF-168F18/" title="Previous page in this title">< Prev</a><a class="active page_link next" href="/books/n/micad/FPTQ-18F/" title="Next page in this title">Next ></a></div></div></div></div></div>
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<div class="main-content lit-style" itemscope="itemscope" itemtype="http://schema.org/CreativeWork"><div class="meta-content fm-sec"><h1 id="_NBK23080_"><span class="title" itemprop="name">6-(3'-[<sup>18</sup>F]Fluoropropyl)-2-(4'-dimethylamino)phenylimidazol[1,2-α]pyridine</span></h1><div itemprop="alternativeHeadline" class="subtitle whole_rhythm">[<sup>18</sup>F]FPPIP</div><p class="contrib-group"><span itemprop="author">Kenneth T. Cheng</span>, PhD.</p><a data-jig="ncbitoggler" href="#__NBK23080_ai__" style="border:0;text-decoration:none">Author Information and Affiliations</a><div style="display:none" class="ui-widget" id="__NBK23080_ai__"><div class="contrib half_rhythm"><span itemprop="author">Kenneth T. Cheng</span>, PhD<div class="affiliation small">
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National Center for Biotechnology Information, NLM, NIH, Bethesda, MD,
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<span class="before-email-separator"></span><span class="email-label">Email: </span><a href="mailto:dev@null" data-email="vog.hin.mln.ibcn@dacim" class="oemail">vog.hin.mln.ibcn@dacim</a>
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||
</div></div></div><p class="small">Created: <span itemprop="datePublished">October 3, 2006</span>; Last Update: <span itemprop="dateModified">April 9, 2008</span>.</p></div><div class="jig-ncbiinpagenav body-content whole_rhythm" data-jigconfig="allHeadingLevels: ['h2'],smoothScroll: false" itemprop="text"><div id="FPPIP18F.T1" class="table"><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK23080/table/FPPIP18F.T1/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__FPPIP18F.T1_lrgtbl__"><table><tbody><tr><td rowspan="1" colspan="1" style="text-align:right;vertical-align:top;">
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||
<b>Chemical name:</b>
|
||
</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">6-(3'-[<sup>18</sup>F]Fluoropropyl)-2-(4'-dimethylamino)phenylimidazol[1,2-α]pyridine</td><td rowspan="9" colspan="1" style="text-align:left;vertical-align:middle;">
|
||
<a href="https://pubchem.ncbi.nlm.nih.gov/substance/22395173" title="View this structure in PubChem" class="img_link" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem"><img src="https://pubchem.ncbi.nlm.nih.gov/image/imgsrv.fcgi?t=l&sid=22395173" alt="image 22395173 in the ncbi pubchem database" /></a>
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</td></tr><tr><td rowspan="1" colspan="1" style="text-align:right;vertical-align:top;">
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||
<b>Abbreviated name:</b>
|
||
</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">[<sup>18</sup>F]FPPIP</td></tr><tr><td rowspan="1" colspan="1" style="text-align:right;vertical-align:top;">
|
||
<b>Synonym:</b>
|
||
</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td></tr><tr><td rowspan="1" colspan="1" style="text-align:right;vertical-align:top;">
|
||
<b>Agent Category:</b>
|
||
</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Compound</td></tr><tr><td rowspan="1" colspan="1" style="text-align:right;vertical-align:top;">
|
||
<b>Target:</b>
|
||
</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Amyloid-β (Aβ)</td></tr><tr><td rowspan="1" colspan="1" style="text-align:right;vertical-align:top;">
|
||
<b>Target Category:</b>
|
||
</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Specific binding</td></tr><tr><td rowspan="1" colspan="1" style="text-align:right;vertical-align:top;">
|
||
<b>Method of detection:</b>
|
||
</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Positron Emission Tomography (PET)</td></tr><tr><td rowspan="1" colspan="1" style="text-align:right;vertical-align:top;">
|
||
<b>Source of signal/contrast:</b>
|
||
</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"><sup>18</sup>F</td></tr><tr><td rowspan="1" colspan="1" style="text-align:right;vertical-align:top;">
|
||
<b>Activation:</b>
|
||
</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">No</td></tr><tr><td rowspan="1" colspan="1" style="text-align:right;vertical-align:top;">
|
||
<b>Studies:</b>
|
||
</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<ul class="simple-list"><li class="half_rhythm"><div>
|
||
<img alt="Checkbox" src="/corehtml/pmc/css/bookshelf/2.26/img/studies.checkbox.png" />
|
||
<i>In vitro</i>
|
||
|
||
</div></li></ul>
|
||
<ul class="simple-list"><li class="half_rhythm"><div>
|
||
<img alt="Checkbox" src="/corehtml/pmc/css/bookshelf/2.26/img/studies.checkbox.png" /> Non-human primates
|
||
</div></li></ul>
|
||
</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Click on the above structure for additional information in <a href="http://pubchem.ncbi.nlm.nih.gov" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">PubChem</a>.</td></tr></tbody></table></div></div><div id="FPPIP18F.Background"><h2 id="_FPPIP18F_Background_">Background</h2><p>[<a href="/entrez/query.fcgi?cmd=PureSearch&db=pubmed&details_term=%5B18F%5DFPPIP%20OR%20FPPIP" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">PubMed</a>]</p><p>6-(3'-[<sup>18</sup>F]Fluoropropyl)-2-(4'-dimethylaminophenylimidazol[1,2-α]pyridine ([<sup>18</sup>F]FPPIP) is a radioligand that was developed for positron emission tomography (PET) imaging of amyloid-β (Aβ) plaques in the central nervous system (CNS) for detection of Alzheimer’s disease (AD) (<a class="bk_pop" href="#FPPIP18F.REF.1">1</a>). <sup>18</sup>F is a positron emitter with a physical <i>t</i><sub>½</sub> of 109.7 min.</p><p>Aβ-peptide was sequenced from the meningeal blood vessels of AD patients and individuals with Downs syndrome (<a class="bk_pop" href="#FPPIP18F.REF.2">2</a>). Aβ peptides contain 40−42 amino acid residues and are metabolic products of the Aβ precursor protein (APP) from cleavage by β- and γ-secretases (<a class="bk_pop" href="#FPPIP18F.REF.3">3</a>). Aβ is also identified as the primary component of the neuritic plaques of AD patient brain tissue (<a class="bk_pop" href="#FPPIP18F.REF.4">4</a>). The cloning of the gene that encodes the APP and its localization to chromosome 21 led to the hypothesis that Aβ accumulation is the primary event in AD pathogenesis (<a class="bk_pop" href="#FPPIP18F.REF.2">2</a>, <a class="bk_pop" href="#FPPIP18F.REF.5">5</a>). This hypothesis proposes that neuronal death in AD is related to the toxic effect of Aβ on the adjacent cell bodies or cell processes (<a class="bk_pop" href="#FPPIP18F.REF.6">6</a>). AD is a progressive, neurodegenerative disorders of the CNS, and is characterized by a common set of clinical and pathological features (<a class="bk_pop" href="#FPPIP18F.REF.3">3</a>). In addition to Aβ, the microtubule-associated protein tau is also found in the cell body and axons of neurons as neurofibrillary tangles.</p><p>The search for a cure or effective treatment of AD requires <i>in vivo</i> detection and quantification of Aβ in the brain for evaluation of the efficacy of AD therapy (<a class="bk_pop" href="#FPPIP18F.REF.3">3</a>). Various amyloid-imaging probes have been developed for PET, single-photon emission computed tomography, and optical imaging. These compounds generally have high binding affinity for amyloid fibrils and adequate permeability of blood−brain barrier (BBB) (<a class="bk_pop" href="#FPPIP18F.REF.7">7</a>). Klunk et al. (<a class="bk_pop" href="#FPPIP18F.REF.8">8</a>) studied [<a href="/books/n/micad/PIB11C/"><sup>11</sup>C]6-OH-BTA-1</a> in AD patients and showed the potential usefulness of these probes. [<sup>123</sup>I]6-iodo-2(4'-<i>N</i>,<i>N</i>'-dimethylamino)phenylimidazol[1,2-α]pyridine (<a href="/books/n/micad/IMPY/">[<sup>123</sup>I]IMPY</a>) has been reported as a potential SPECT agent for imaging Aβ plaques. Because PET can provide more accurate quantitative imaging, Zeng et al. (<a class="bk_pop" href="#FPPIP18F.REF.1">1</a>) developed <sup>18</sup>F-labeled IMPY analogs for PET imaging of AD plaques. [<sup>18</sup>F]FPPIP is produced by replacing the iodo group on IMPY with fluoropropyl.</p></div><div id="FPPIP18F.Synthesis"><h2 id="_FPPIP18F_Synthesis_">Synthesis</h2><p>[<a href="/entrez/query.fcgi?cmd=PureSearch&db=pubmed&details_term=%28%5B18F%5DFPPIP%20OR%20FPPIP%29%20AND%20synthesis" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">PubMed</a>]</p><p>Zeng et al. (<a class="bk_pop" href="#FPPIP18F.REF.1">1</a>) reported the synthesis of FPPIP from IMPY. IMPY was first prepared from condensation reaction between commercially available 2-amino-5-iodopyridine and 2-bromo-4'-dimethylaminoacetophenone in the presence of sodium bicarbonate as a mild base. IMPY was coupled with the tributyl(propylene)tin in toluene and palladium at 100ºC for 20 h to produce the corresponding intermediate alkene. This alkene was then converted to a hydroxyethyl compound by a hydroboration-oxidation reaction. FPPIP was finally produced by reaction of the hydroxyethyl compound with diethylaminosulfur trifluoride in methylene chloride at −78ºC to 23ºC for 2 h with a yield of 44%.</p><p>The radiosynthesis of [<sup>18</sup>F]FPPIP was accomplished by using the tosylate FPPIP precursor that was produced from reaction of FPPIP with tosylate chloride and triethylamine in methylene chloride at room temperature for 15 h with a yield of 52% (<a class="bk_pop" href="#FPPIP18F.REF.1">1</a>). This precursor was then reacted with anhydrous <sup>18</sup>F-labeled potassium fluoride and K<sub>222</sub> in acetonitrile for 10 min at 90ºC. The entire radiolabeling procedure required 105 min from the end of bombardment. The decay-corrected yield was 51% and the radiochemical purity was >98%. The specific activity was 62.9−85.1GBq/μmol (1.7−2.3 Ci/μmol) at the time of injection.</p></div><div id="FPPIP18F.In_Vitro_Studies_Tes"><h2 id="_FPPIP18F_In_Vitro_Studies_Tes_"><i>In Vitro</i> Studies: Testing in Cells and Tissues</h2><p>[<a href="/entrez/query.fcgi?cmd=PureSearch&db=pubmed&details_term=%28%5B18F%5DFPPIP%20OR%20FPPIP%29%20AND%20in%20vitro" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">PubMed</a>]</p><p><i>In vitro</i> binding studies with unlabeled FPPIP were conducted with quantitative autoradiography by binding competition with [<sup>125</sup>I]IMPY in human AD cortical tissues (<a class="bk_pop" href="#FPPIP18F.REF.1">1</a>). The inhibition constant (<i>K</i><sub>i</sub>) was determined to be 48.3 nM. In comparison, IMPY had a <i>K</i><sub>i</sub> value of 10.3 nM. The lipophilicity coefficient log <i>P</i> (1-octanol and phosphate buffer at pH 7.4) of FPPIP was 2.84 whereas IMPY had a value of 3.58. The <i>in vitro</i> binding of [<sup>18</sup>F]FPPIP was shown in postmortem AD brain sections by autoradiography. Specific binding was found in cortical gray matter but not in the white matter. This specific binding was eliminated when the sections were pretreated with unlabeled FPPIP. No specific binding was found in normal brain sections. In a study that used <i>in vitro</i> Immunostaining with an Aβ-specific 4G8 monoclonal antibody, [<sup>18</sup>F]FPPIP labeling demonstrated a good correlation with Aβ plaque labeling by AG8 in the AD brain sections.</p></div><div id="FPPIP18F.Animal_Studies"><h2 id="_FPPIP18F_Animal_Studies_">Animal Studies</h2><div id="FPPIP18F.Rodents"><h3>Rodents</h3><p>[<a href="/entrez/query.fcgi?cmd=PureSearch&db=pubmed&details_term=%28%5B18F%5DFPPIP%20OR%20FPPIP%29%20AND%20rodentia" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">PubMed</a>]</p><p>No publication is currently available.</p></div><div id="FPPIP18F.Other_NonPrimate_Mam"><h3>Other Non-Primate Mammals</h3><p>[<a href="/entrez/query.fcgi?cmd=PureSearch&db=pubmed&details_term=%28%5B18F%5DFPPIP%20OR%20FPPIP%29%20AND%20%28dog%20OR%20rabbit%20OR%20pig%20OR%20sheep%29" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">PubMed</a>]</p><p>No publication is currently available.</p></div><div id="FPPIP18F.NonHuman_Primates"><h3>Non-Human Primates</h3><p>[<a href="/entrez/query.fcgi?cmd=PureSearch&db=pubmed&details_term=%28%5B18F%5DFPPIP%20OR%20FPPIP%29%20AND%20%28primate%20NOT%20human%29" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">PubMed</a>]</p><p>Zeng et al. (<a class="bk_pop" href="#FPPIP18F.REF.1">1</a>) performed PET imaging of [<sup>18</sup>F]FPPIP in a healthy rhesus monkey. The study showed easy brain entry and clearance from normal brain tissue. The peak standard uptake value of [<sup>18</sup>F]FPPIP was 1.6−2.7 at 9 min. Relatively fast nonspecific binding clearance was observed in cerebellum, frontal cortex, and subcortical white matter. No bone radioactivity was observed in the skull, which might indicate low in <i>in vivo</i> defluorination.</p></div></div><div id="FPPIP18F.Human_Studies"><h2 id="_FPPIP18F_Human_Studies_">Human Studies</h2><p>[<a href="/entrez/query.fcgi?cmd=PureSearch&db=pubmed&details_term=%28%5B18F%5DFPPIP%20OR%20FPPIP%29%20AND%20human" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">PubMed</a>]</p><p>No publication is currently available.</p></div><div id="FPPIP18F.references"><h2 id="_FPPIP18F_references_">References</h2><dl class="temp-labeled-list"><dt>1.</dt><dd><div class="bk_ref" id="FPPIP18F.REF.1">Zeng F. , Southerland J.A. , Voll R.J. , Votaw J.R. , Williams L. , Ciliax B.J. , Levey A.I. , Goodman M.M. Synthesis and evaluation of two 18F-labeled imidazo[1,2-a]pyridine analogues as potential agents for imaging beta-amyloid in Alzheimer's disease. <span><span class="ref-journal">Bioorg Med Chem Lett. </span>2006;<span class="ref-vol">
|
||
<strong>16</strong>
|
||
</span>(11):3015–8.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/16574411" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 16574411</span></a>]</div></dd><dt>2.</dt><dd><div class="bk_ref" id="FPPIP18F.REF.2">Hardy J. , Selkoe D.J. The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. <span><span class="ref-journal">Science. </span>2002;<span class="ref-vol">
|
||
<strong>297</strong>
|
||
</span>(5580):353–6.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/12130773" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 12130773</span></a>]</div></dd><dt>3.</dt><dd><div class="bk_ref" id="FPPIP18F.REF.3">Wu C.Y. , Pike V.W. , Wang Y.M. Amyloid imaging: From benchtop to bedside. <span><span class="ref-journal">Current Topcis in Developmental Biology. </span>2005;<span class="ref-vol">
|
||
<strong>70</strong>
|
||
</span>:171–213.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/16338342" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 16338342</span></a>]</div></dd><dt>4.</dt><dd><div class="bk_ref" id="FPPIP18F.REF.4">Masters C.L. , Multhaup G. , Simms G. , Pottgiesser J. , Martins R.N. , Beyreuther K. Neuronal origin of a cerebral amyloid: neurofibrillary tangles of Alzheimer's disease contain the same protein as the amyloid of plaque cores and blood vessels. <span><span class="ref-journal">Embo J. </span>1985;<span class="ref-vol">
|
||
<strong>4</strong>
|
||
</span>(11):2757–63.</span> [<a href="/pmc/articles/PMC554575/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC554575</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/4065091" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 4065091</span></a>]</div></dd><dt>5.</dt><dd><div class="bk_ref" id="FPPIP18F.REF.5">Kang J. , Lemaire H.G. , Unterbeck A. , Salbaum J.M. , Masters C.L. , Grzeschik K.H. , Multhaup G. , Beyreuther K. , Muller-Hill B. The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor. <span><span class="ref-journal">Nature. </span>1987;<span class="ref-vol">
|
||
<strong>325</strong>
|
||
</span>(6106):733–6.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/2881207" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 2881207</span></a>]</div></dd><dt>6.</dt><dd><div class="bk_ref" id="FPPIP18F.REF.6">Carter J. , Lippa C.F. Beta-amyloid, neuronal death and Alzheimer's disease. <span><span class="ref-journal">Curr Mol Med. </span>2001;<span class="ref-vol">
|
||
<strong>1</strong>
|
||
</span>(6):733–7.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/11899259" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 11899259</span></a>]</div></dd><dt>7.</dt><dd><div class="bk_ref" id="FPPIP18F.REF.7">Okamura N. , Suemoto T. , Shimadzu H. , Suzuki M. , Shiomitsu T. , Akatsu H. , Yamamoto T. , Staufenbiel M. , Yanai K. , Arai H. , Sasaki H. , Kudo Y. , Sawada T. Styrylbenzoxazole derivatives for in vivo imaging of amyloid plaques in the brain. <span><span class="ref-journal">J Neurosci. </span>2004;<span class="ref-vol">
|
||
<strong>24</strong>
|
||
</span>(10):2535–41.</span> [<a href="/pmc/articles/PMC6729476/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC6729476</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/15014129" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 15014129</span></a>]</div></dd><dt>8.</dt><dd><div class="bk_ref" id="FPPIP18F.REF.8">Klunk W.E. , Engler H. , Nordberg A. , Wang Y. , Blomqvist G. , Holt D.P. , Bergstrom M. , Savitcheva I. , Huang G.F. , Estrada S. , Ausen B. , Debnath M.L. , Barletta J. , Price J.C. , Sandell J. , Lopresti B.J. , Wall A. , Koivisto P. , Antoni G. , Mathis C.A. , Langstrom B. Imaging brain amyloid in Alzheimer's disease with Pittsburgh Compound-B. <span><span class="ref-journal">Ann Neurol. </span>2004;<span class="ref-vol">
|
||
<strong>55</strong>
|
||
</span>(3):306–19.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/14991808" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 14991808</span></a>]</div></dd></dl></div><div id="bk_toc_contnr"></div></div></div>
|
||
<div class="post-content"><div><div class="half_rhythm"><a href="/books/about/copyright/">Copyright Notice</a></div><div class="small"><span class="label">Bookshelf ID: NBK23080</span><span class="label">PMID: <a href="https://pubmed.ncbi.nlm.nih.gov/20641285" title="PubMed record of this page" ref="pagearea=meta&targetsite=entrez&targetcat=link&targettype=pubmed">20641285</a></span></div><div style="margin-top:2em" class="bk_noprnt"><a class="bk_cntns" href="/books/n/micad/">Contents</a><div class="pagination bk_noprnt"><a class="active page_link prev" href="/books/n/micad/BF-168F18/" title="Previous page in this title">< Prev</a><a class="active page_link next" href="/books/n/micad/FPTQ-18F/" title="Next page in this title">Next ></a></div></div></div></div>
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<div xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"></div><div class="portlet"><div class="portlet_head"><div class="portlet_title"><h3><span>Views</span></h3></div><a name="Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="PDF_download" id="Shutter"></a></div><div class="portlet_content"><ul xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="simple-list"><li><a href="/books/NBK23080/?report=reader">PubReader</a></li><li><a href="/books/NBK23080/?report=printable">Print View</a></li><li><a data-jig="ncbidialog" href="#_ncbi_dlg_citbx_NBK23080" data-jigconfig="width:400,modal:true">Cite this Page</a><div id="_ncbi_dlg_citbx_NBK23080" style="display:none" title="Cite this Page"><div class="bk_tt">Cheng KT. 6-(3'-[18F]Fluoropropyl)-2-(4'-dimethylamino)phenylimidazol[1,2-α]pyridine. 2006 Oct 3 [Updated 2008 Apr 9]. In: Molecular Imaging and Contrast Agent Database (MICAD) [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2004-2013. <span class="bk_cite_avail"></span></div></div></li><li><a href="/books/NBK23080/pdf/Bookshelf_NBK23080.pdf">PDF version of this page</a> (378K)</li><li><a href="/books/n/micad/toc/bin/micad.csv">MICAD summary (CSV file)</a></li></ul></div></div><div class="portlet"><div class="portlet_head"><div class="portlet_title"><h3><span>In this page</span></h3></div><a name="Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="page-toc" id="Shutter"></a></div><div class="portlet_content"><ul xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="simple-list"><li><a href="#FPPIP18F.Background" ref="log$=inpage&link_id=inpage">Background</a></li><li><a href="#FPPIP18F.Synthesis" ref="log$=inpage&link_id=inpage">Synthesis</a></li><li><a href="#FPPIP18F.In_Vitro_Studies_Tes" ref="log$=inpage&link_id=inpage"><i>In Vitro</i> Studies: Testing in Cells and Tissues</a></li><li><a href="#FPPIP18F.Animal_Studies" ref="log$=inpage&link_id=inpage">Animal Studies</a></li><li><a href="#FPPIP18F.Human_Studies" ref="log$=inpage&link_id=inpage">Human Studies</a></li><li><a href="#FPPIP18F.references" ref="log$=inpage&link_id=inpage">References</a></li></ul></div></div><div class="portlet"><div class="portlet_head"><div class="portlet_title"><h3><span>Search MICAD</span></h3></div><a name="Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="source-application" id="Shutter"></a></div><div class="portlet_content"><form xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" name="frmSearch" method="get" action="/books/NBK5330/" id="frmSearch"><script type="text/javascript" src="/corehtml/pmc//js/bookshelf/micad.js">/**/</script><label class="offscreen_noflow" for="txtfield">Search term</label><input id="txtfield" type="text" name="f1_term" size="22" onKeyPress="KeyPress('micad',event,'/books/NBK5330/','')" /><button name="f1_search" type="submit">Go</button><button onclick="this.form.reset();" type="reset">Clear</button><p><b>Limit my Search:</b></p><div class="clearfix"><label for="detection">Method of detection:</label><div class="right"><select name="detection" id="detection" style="width:200px"><option value="" selected="selected">Any</option><option value="(MRI OR "Magnetic resonance imaging" OR MRS)">MRI</option><option value="Multimodal">Multimodal imaging</option><option value="Optical">Optical imaging</option><option value="PET">PET</option><option value="Photoacoustic">Photoacoustic imaging</option><option value="(SPECT OR planar)">SPECT</option><option value="Ultrasound">Ultrasound</option><option value="(x-ray OR ct)">X-ray, CT</option></select></div></div><div class="clearfix"><label for="signal">Source of signal/contrast:</label><div class="right"><select name="signal" id="signal" style="width:200px"><option value="" selected="selected">Any</option><optgroup label="MRI agents"><option value="(Copper OR Cu)">Copper</option><option value="(Europium OR Eu3+)">Europium</option><option value="(Fluorine OR 19F)">Fluorine</option><option value="(Gadolinium OR Gd3+)">Gadolinium</option><option value=""Hyperpolarized 13C"">Hyperpolarized 13C</option><option value=""Iron oxide"">Iron oxide</option><option value=""Nitroxide radicals"">Nitroxide radicals</option><option value="(Oxygen OR 17O)">Oxygen</option><option value="Thulium">Thulium</option></optgroup><optgroup label="Multimodal agents"><option value="((Gadolinium OR Gd3+) AND Optical)">Gadolinium and optical</option><option value="((Gadolinium OR Gd3+) AND (Gold OR Au))">Gadolinium and Gold</option><option value="("Iron oxide" AND (64Cu OR 124I OR 111In))">Iron oxide and
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