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<script type="text/javascript" src="/corehtml/pmc/jatsreader/ptpmc_3.22/js/jr.boots.min.js"> </script><title>3-β-(4-Iodophenyl)tropane-2-β-carboxylic acid 2-[18F]fluoroethyl ester - Molecular Imaging and Contrast Agent Database (MICAD) - NCBI Bookshelf</title>
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<meta name="citation_inbook_title" content="Molecular Imaging and Contrast Agent Database (MICAD) [Internet]">
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<meta name="citation_title" content="3-β-(4-Iodophenyl)tropane-2-β-carboxylic acid 2-[18F]fluoroethyl ester">
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<meta name="citation_publisher" content="National Center for Biotechnology Information (US)">
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<meta name="citation_date" content="2008/09/17">
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<meta name="citation_author" content="Kam Leung">
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<meta name="citation_pmid" content="20641473">
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<meta name="DC.Title" content="3-β-(4-Iodophenyl)tropane-2-β-carboxylic acid 2-[18F]fluoroethyl ester">
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<meta name="DC.Publisher" content="National Center for Biotechnology Information (US)">
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<meta name="DC.Contributor" content="Kam Leung">
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<meta name="DC.Date" content="2008/09/17">
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<meta name="description" content="Dopamine, a neurotransmitter, plays an important role in the mediation of movement, cognition, and emotion. Parkinson’s disease (PD) is associated with a loss of dopamine-containing neurons in the striatum, resulting in a loss of dopamine transporters (DAT) in the presynaptic nerve terminals (1, 2). Reduced DAT density is inversely correlated with the severity of motor dysfunction in PD patients. Several cocaine analogs have been developed for the evaluation of DAT density in the neurons of PD patients. Radiolabeled 2-β-carboxymethoxy-3-β-(4-iodophenyl)tropane (β-CIT) and N-(3-fluoropropyl)-2β-carbomethoxy-3β-(4-iodophenyl)nortropane (FP-CIT) have been used for brain imaging (3-6). Because of the short physical half-life of 11C-labeled analogs, equilibrium conditions are difficult to achieve in positron emission tomography (PET) measurements. [123I]β-CIT was studied with single-photon emission computed tomography (SPECT), which showed slow tracer uptake kinetics (7, 8). This led to the development of 3-β-(4-iodophenyl)tropane-2-β-carboxylic acid 2-[18F]fluoroethyl ester ([18F]FE@CIT) for PET brain imaging in PD patients (9).">
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<meta name="og:description" content="Dopamine, a neurotransmitter, plays an important role in the mediation of movement, cognition, and emotion. Parkinson’s disease (PD) is associated with a loss of dopamine-containing neurons in the striatum, resulting in a loss of dopamine transporters (DAT) in the presynaptic nerve terminals (1, 2). Reduced DAT density is inversely correlated with the severity of motor dysfunction in PD patients. Several cocaine analogs have been developed for the evaluation of DAT density in the neurons of PD patients. Radiolabeled 2-β-carboxymethoxy-3-β-(4-iodophenyl)tropane (β-CIT) and N-(3-fluoropropyl)-2β-carbomethoxy-3β-(4-iodophenyl)nortropane (FP-CIT) have been used for brain imaging (3-6). Because of the short physical half-life of 11C-labeled analogs, equilibrium conditions are difficult to achieve in positron emission tomography (PET) measurements. [123I]β-CIT was studied with single-photon emission computed tomography (SPECT), which showed slow tracer uptake kinetics (7, 8). This led to the development of 3-β-(4-iodophenyl)tropane-2-β-carboxylic acid 2-[18F]fluoroethyl ester ([18F]FE@CIT) for PET brain imaging in PD patients (9).">
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id="jr-fip-info-p"><a id="jr-fip-prev" class="wsprkl btn" title="Jump to previuos match">◀</a><button id="jr-fip-matches">no matches yet</button><a id="jr-fip-next" class="wsprkl btn" title="Jump to next match">▶</a></nav></nav></div><div id="jr-epub-interstitial" class="hidden"></div><div id="jr-content"><article data-type="main"><div class="main-content lit-style" itemscope="itemscope" itemtype="http://schema.org/CreativeWork"><div class="meta-content fm-sec"><div class="fm-sec"><h1 id="_NBK23271_"><span class="title" itemprop="name">3-β-(4-Iodophenyl)tropane-2-β-carboxylic acid 2-[<sup>18</sup>F]fluoroethyl ester </span></h1><div itemprop="alternativeHeadline" class="subtitle whole_rhythm">[<sup>18</sup>F]FE@CIT</div><p class="contribs">Leung K.</p><p class="fm-aai"><a href="#_NBK23271_pubdet_">Publication Details</a></p></div></div><div class="jig-ncbiinpagenav body-content whole_rhythm" data-jigconfig="allHeadingLevels: ['h2'],smoothScroll: false" itemprop="text"><div class="iconblock whole_rhythm clearfix ten_col table-wrap" id="figFEatCIT18FT1"><a href="/books/NBK23271/table/FEatCIT18F.T1/?report=objectonly" target="object" title="Table" class="img_link icnblk_img" rid-ob="figobFEatCIT18FT1"><img class="small-thumb" src="/corehtml/pmc/css/bookshelf/2.26/img/table-icon.gif" alt="Table Icon" /></a><div class="icnblk_cntnt"><h4 id="FEatCIT18F.T1"><a href="/books/NBK23271/table/FEatCIT18F.T1/?report=objectonly" target="object" rid-ob="figobFEatCIT18FT1">Table</a></h4><p class="float-caption no_bottom_margin">
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<i>In vitro</i>
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Rodents
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</p></div></div><div id="FEatCIT18F.Background"><h2 id="_FEatCIT18F_Background_">Background</h2><p>[<a href="/entrez/query.fcgi?cmd=PureSearch&db=pubmed&details_term=FE@CIT" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">PubMed</a>]</p><p>Dopamine, a neurotransmitter, plays an important role in the mediation of movement, cognition, and emotion. Parkinson’s disease (PD) is associated with a loss of dopamine-containing neurons in the striatum, resulting in a loss of dopamine transporters (DAT) in the presynaptic nerve terminals (<a class="bibr" href="#FEatCIT18F.REF.1" rid="FEatCIT18F.REF.1">1</a>, <a class="bibr" href="#FEatCIT18F.REF.2" rid="FEatCIT18F.REF.2">2</a>). Reduced DAT density is inversely correlated with the severity of motor dysfunction in PD patients. Several cocaine analogs have been developed for the evaluation of DAT density in the neurons of PD patients. Radiolabeled 2-β-carboxymethoxy-3-β-(4-iodophenyl)tropane (β-CIT) and <i>N</i>-(3-fluoropropyl)-2β-carbomethoxy-3β-(4-iodophenyl)nortropane (FP-CIT) have been used for brain imaging (<a href="#FEatCIT18F.REF.3">3-6</a>). Because of the short physical half-life of <sup>11</sup>C-labeled analogs, equilibrium conditions are difficult to achieve in positron emission tomography (PET) measurements. [<sup>123</sup>I]β-CIT was studied with single-photon emission computed tomography (SPECT), which showed slow tracer uptake kinetics (<a class="bibr" href="#FEatCIT18F.REF.7" rid="FEatCIT18F.REF.7">7</a>, <a class="bibr" href="#FEatCIT18F.REF.8" rid="FEatCIT18F.REF.8">8</a>). This led to the development of 3-β-(4-iodophenyl)tropane-2-β-carboxylic acid 2-[<sup>18</sup>F]fluoroethyl ester ([<sup>18</sup>F]FE@CIT) for PET brain imaging in PD patients (<a class="bibr" href="#FEatCIT18F.REF.9" rid="FEatCIT18F.REF.9">9</a>).</p></div><div id="FEatCIT18F.Synthesis"><h2 id="_FEatCIT18F_Synthesis_">Synthesis</h2><p>[<a href="/entrez/query.fcgi?cmd=PureSearch&db=pubmed&details_term=FE@CIT%20AND%20synthesis" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">PubMed</a>]</p><p>[<sup>18</sup>F]FE@CIT was synthesized by reaction of 3-β-(4-iodophenyl)tropane-2-β-carboxylic acid with 2-bromo-1-[<sup>18</sup>F]fluoroethane ([<sup>18</sup>F]BFE) for 20 min at 150°C (<a class="bibr" href="#FEatCIT18F.REF.9" rid="FEatCIT18F.REF.9">9</a>). [<sup>18</sup>F]BFE was prepared by nucleophilic fluorination of 2-bromoethyl triflate using the standard [<sup>18</sup>F]KF Kryptofix complex for 10 min at 100°C. The radiochemical yields of [<sup>18</sup>F]FE@CIT were >90% (based on [<sup>18</sup>F]BFE) with a radiochemical purity of >99% and specific activity of >416 GBq/µmol (11.2 Ci/µmol) at the end of synthesis.</p></div><div id="FEatCIT18F.In_Vitro_studies_Tes"><h2 id="_FEatCIT18F_In_Vitro_studies_Tes_"><i>In Vitro</i> studies: Testing in Cells and Tissues</h2><p>[<a href="/entrez/query.fcgi?cmd=PureSearch&db=pubmed&details_term=FE@CIT%20AND%20in%20vitro" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">PubMed</a>]</p><p><i>In vitro</i> [<sup>18</sup>F]FE@CIT autoradiography of frozen brain sections obtained from rats was performed by Ettlinger et al. (<a class="bibr" href="#FEatCIT18F.REF.10" rid="FEatCIT18F.REF.10">10</a>) The striatum exhibited a higher radioactivity level than the cortex. Gu et al. (<a class="bibr" href="#FEatCIT18F.REF.11" rid="FEatCIT18F.REF.11">11</a>) showed that binding affinities (<i>K</i><sub>i</sub>) of FE@CIT at DAT, serotonin transporter (SERT), and norepinephrine transporter (NET) were 0.93, 4.02, and 116 nM, respectively. FE@CIT exhibited a higher DAT affinity than FP-CIT for DAT (8.29 nM) and more selective affinity for DAT over SERT and NET.</p></div><div id="FEatCIT18F.Animal_Studies"><h2 id="_FEatCIT18F_Animal_Studies_">Animal Studies</h2><div id="FEatCIT18F.Rodents"><h3>Rodents</h3><p>
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<a href="/entrez/query.fcgi?cmd=PureSearch&db=pubmed&details_term=FE@CIT%20AND%20rodentia" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">[PubMed]</a>
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</p><p>Mitterhauser et al. (<a class="bibr" href="#FEatCIT18F.REF.9" rid="FEatCIT18F.REF.9">9</a>) performed biodistribution studies in rats (<i>n</i> = 4/group) at 5, 15, 30, 60, and 120 min after injection of 1.25–2.23 MBq (0.033–0.06 mCi). At 60 min after injection, the radioactivity in the striatum was 1.23% injected dose/g (ID/g), which was greater than the thalamus (0.42% ID/g) and cerebellum (0.33% ID/g). The highest striatum/cerebellum ratio was 3.73, and the highest thalamus/cerebellum ratio was 1.65. The other organs with high accumulation were the kidney (3.86% ID/g), liver (3.06% ID/g), and lung (0.86% ID/g), whereas the bowels (0.54% ID/g), bone (0.14% ID/g), blood (0.15% ID/g), and muscle (0.16% ID/g) exhibited little or low accumulation at 60 min. There were continuous increases in radioactivity in the kidneys and liver from 5 min to 120 min. No blocking experiments were performed.</p></div><div id="FEatCIT18F.Other_NonPrimate_Mam"><h3>Other Non-Primate Mammals</h3><p>[<a href="/sites/entrez?Db=pubmed&Cmd=DetailsSearch&Term=FE%40CIT+AND+(dog+or+pig+or+sheep+or+rabbit)" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">PubMed</a>]</p><p>No publication is currently available.</p></div><div id="FEatCIT18F.NonHuman_Primates"><h3>Non-Human Primates</h3><p>[<a href="/entrez/query.fcgi?cmd=PureSearch&db=pubmed&details_term=FE@CIT%20AND%20monkeys" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">PubMed</a>]</p><p>No publication is currently available.</p></div></div><div id="FEatCIT18F._Human_Studies"><h2 id="_FEatCIT18F__Human_Studies_">Human Studies</h2><p>[<a href="/entrez/query.fcgi?cmd=PureSearch&db=pubmed&details_term=FE@CIT%20AND%20human" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">PubMed</a>]</p><p>No publication is currently available.</p></div><div id="FEatCIT18F._Human_Studies_1"><h2 id="_FEatCIT18F__Human_Studies_1_">Human Studies</h2><p>MH34006, MH47370, NS40587</p></div><div id="FEatCIT18F.references"><h2 id="_FEatCIT18F_references_">References</h2><dl class="temp-labeled-list"><dl class="bkr_refwrap"><dt>1.</dt><dd><div class="bk_ref" id="FEatCIT18F.REF.1">Carbon M. , Ghilardi M.F. , Feigin A. , Fukuda M. , Silvestri G. , Mentis M.J. , Ghez C. , Moeller J.R. , Eidelberg D. Learning networks in health and Parkinson's disease: reproducibility and treatment effects. <span><span class="ref-journal">Hum Brain Mapp. </span>2003;<span class="ref-vol">
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<strong>19</strong>
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</span>(3):197–211.</span> [<a href="/pmc/articles/PMC6871830/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC6871830</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/12811735" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 12811735</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>2.</dt><dd><div class="bk_ref" id="FEatCIT18F.REF.2">Chesselet M.F. , Delfs J.M. Basal ganglia and movement disorders: an update. <span><span class="ref-journal">Trends Neurosci. </span>1996;<span class="ref-vol">
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<strong>19</strong>
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</span>(10):417–22.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/8888518" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 8888518</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>3.</dt><dd><div class="bk_ref" id="FEatCIT18F.REF.3">Abi-Dargham A. , Gandelman M.S. , DeErausquin G.A. , Zea-Ponce Y. , Zoghbi S.S. , Baldwin R.M. , Laruelle M. , Charney D.S. , Hoffer P.B. , Neumeyer J.L. , Innis R.B. SPECT imaging of dopamine transporters in human brain with iodine-123-fluoroalkyl analogs of beta-CIT. <span><span class="ref-journal">J Nucl Med. </span>1996;<span class="ref-vol">
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<strong>37</strong>
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</span>(7):1129–33.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/8965183" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 8965183</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>4.</dt><dd><div class="bk_ref" id="FEatCIT18F.REF.4">Chaly T. , Dhawan V. , Kazumata K. , Antonini A. , Margouleff C. , Dahl J.R. , Belakhlef A. , Margouleff D. , Yee A. , Wang S. , Tamagnan G. , Neumeyer J.L. , Eidelberg D. Radiosynthesis of [18F] N-3-fluoropropyl-2-beta-carbomethoxy-3-beta-(4-iodophenyl) nortropane and the first human study with positron emission tomography. <span><span class="ref-journal">Nucl Med Biol. </span>1996;<span class="ref-vol">
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<strong>23</strong>
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</span>(8):999–1004.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/9004288" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 9004288</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>5.</dt><dd><div class="bk_ref" id="FEatCIT18F.REF.5">Kazumata K. , Dhawan V. , Chaly T. , Antonini A. , Margouleff C. , Belakhlef A. , Neumeyer J. , Eidelberg D. Dopamine transporter imaging with fluorine-18-FPCIT and PET. <span><span class="ref-journal">J Nucl Med. </span>1998;<span class="ref-vol">
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<strong>39</strong>
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</span>(9):1521–30.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/9744335" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 9744335</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>6.</dt><dd><div class="bk_ref" id="FEatCIT18F.REF.6">Lundkvist C. , Halldin C. , Ginovart N. , Swahn C.G. , Farde L. [18F] beta-CIT-FP is superior to [11C] beta-CIT-FP for quantitation of the dopamine transporter. <span><span class="ref-journal">Nucl Med Biol. </span>1997;<span class="ref-vol">
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<strong>24</strong>
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</span>(7):621–7.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/9352532" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 9352532</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>7.</dt><dd><div class="bk_ref" id="FEatCIT18F.REF.7">Ishikawa T. , Dhawan V. , Kazumata K. , Chaly T. , Mandel F. , Neumeyer J. , Margouleff C. , Babchyck B. , Zanzi I. , Eidelberg D. Comparative nigrostriatal dopaminergic imaging with iodine-123-beta CIT-FP/SPECT and fluorine-18-FDOPA/PET. <span><span class="ref-journal">J Nucl Med. </span>1996;<span class="ref-vol">
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<strong>37</strong>
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</span>(11):1760–5.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/8917170" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 8917170</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>8.</dt><dd><div class="bk_ref" id="FEatCIT18F.REF.8">Laruelle M. , Wallace E. , Seibyl J.P. , Baldwin R.M. , Zea-Ponce Y. , Zoghbi S.S. , Neumeyer J.L. , Charney D.S. , Hoffer P.B. , Innis R.B. Graphical, kinetic, and equilibrium analyses of in vivo [123I] beta-CIT binding to dopamine transporters in healthy human subjects. <span><span class="ref-journal">J Cereb Blood Flow Metab. </span>1994;<span class="ref-vol">
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<strong>14</strong>
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</span>(6):982–94.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/7929662" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 7929662</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>9.</dt><dd><div class="bk_ref" id="FEatCIT18F.REF.9">Mitterhauser M. , Wadsak W. , Mien L.K. , Hoepping A. , Viernstein H. , Dudczak R. , Kletter K. Synthesis and biodistribution of [18F]FE@CIT, a new potential tracer for the dopamine transporter. <span><span class="ref-journal">Synapse. </span>2005;<span class="ref-vol">
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<strong>55</strong>
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</span>(2):73–9.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/15529336" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 15529336</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>10.</dt><dd><div class="bk_ref" id="FEatCIT18F.REF.10">Ettlinger D.E. , Hausler D. , Wadsak W. , Girschele F. , Sindelar K.M. , Mien L.K. , Ungersbock J. , Viernstein H. , Kletter K. , Dudczak R. , Mitterhauser M. Metabolism and autoradiographic evaluation of [(18)F]FE@CIT: a Comparison with [(123)I]beta-CIT and [(123)I]FP-CIT. <span><span class="ref-journal">Nucl Med Biol. </span>2008;<span class="ref-vol">
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<strong>35</strong>
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</span>(4):475–9.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/18482685" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 18482685</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>11.</dt><dd><div class="bk_ref" id="FEatCIT18F.REF.11">Gu X.H. , Zong R. , Kula N.S. , Baldessarini R.J. , Neumeyer J.L. Synthesis and biological evaluation of a series of novel N- or O-fluoroalkyl derivatives of tropane: potential positron emission tomography (PET) imaging agents for the dopamine transporter. <span><span class="ref-journal">Bioorg Med Chem Lett. </span>2001;<span class="ref-vol">
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<strong>11</strong>
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</span>(23):3049–53.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/11714608" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 11714608</span></a>]</div></dd></dl></dl></div><div id="bk_toc_contnr"></div></div></div><div class="fm-sec"><h2 id="_NBK23271_pubdet_">Publication Details</h2><h3>Author Information and Affiliations</h3><div class="contrib half_rhythm"><span itemprop="author">Kam Leung</span>, PhD<div class="affiliation small">
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National Center for Biotechnology Information, NLM, NIH, Bethesda, MD,
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<span class="before-email-separator"></span><span class="email-label">Email: </span><a href="mailto:dev@null" data-email="vog.hin.mln.ibcn@dacim" class="oemail">vog.hin.mln.ibcn@dacim</a>
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</div></div><h3>Publication History</h3><p class="small">Created: <span itemprop="datePublished">August 11, 2008</span>; Last Update: <span itemprop="dateModified">September 17, 2008</span>.</p><h3>Copyright</h3><div><div class="half_rhythm"><a href="/books/about/copyright/">Copyright Notice</a></div></div><h3>Publisher</h3><p><a href="http://www.ncbi.nlm.nih.gov/" ref="pagearea=page-banner&targetsite=external&targetcat=link&targettype=publisher">National Center for Biotechnology Information (US)</a>, Bethesda (MD)</p><h3>NLM Citation</h3><p>Leung K. 3-β-(4-Iodophenyl)tropane-2-β-carboxylic acid 2-[18F]fluoroethyl ester. 2008 Aug 11 [Updated 2008 Sep 17]. In: Molecular Imaging and Contrast Agent Database (MICAD) [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2004-2013. <span class="bk_cite_avail"></span></p></div><div class="small-screen-prev"><a href="/books/n/micad/FESP18F/?report=reader"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 100 100" preserveAspectRatio="none"><path d="M75,30 c-80,60 -80,0 0,60 c-30,-60 -30,0 0,-60"></path><text x="20" y="28" textLength="60" style="font-size:25px">Prev</text></svg></a></div><div class="small-screen-next"><a href="/books/n/micad/FES-M-4F-18F/?report=reader"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 100 100" preserveAspectRatio="none"><path d="M25,30c80,60 80,0 0,60 c30,-60 30,0 0,-60"></path><text x="20" y="28" textLength="60" style="font-size:25px">Next</text></svg></a></div></article><article data-type="table-wrap" id="figobFEatCIT18FT1"><div id="FEatCIT18F.T1" class="table"><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK23271/table/FEatCIT18F.T1/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__FEatCIT18F.T1_lrgtbl__"><table><tbody><tr><td rowspan="1" colspan="1" style="text-align:right;vertical-align:top;">
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<b>Chemical name:</b>
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</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">3-β-(4-Iodophenyl)tropane-2-β-carboxylic acid 2-[<sup>18</sup>F]fluoroethyl ester</td><td rowspan="9" colspan="1" style="text-align:left;vertical-align:middle;">
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<a href="https://pubchem.ncbi.nlm.nih.gov/substance/50130529" title="View this structure in PubChem" class="img_link" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem"><img src="https://pubchem.ncbi.nlm.nih.gov/image/imgsrv.fcgi?t=l&sid=50130529" alt="image 50130529 in the ncbi pubchem database" /></a>
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</td></tr><tr><td rowspan="1" colspan="1" style="text-align:right;vertical-align:top;">
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<b>Abbreviated name:</b>
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</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">[<sup>18</sup>F]FE@CIT</td></tr><tr><td rowspan="1" colspan="1" style="text-align:right;vertical-align:top;">
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<b>Synonym:</b>
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</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td></tr><tr><td rowspan="1" colspan="1" style="text-align:right;vertical-align:top;">
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<b>Agent Category:</b>
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</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Compound</td></tr><tr><td rowspan="1" colspan="1" style="text-align:right;vertical-align:top;">
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<b>Target:</b>
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</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Dopamine transporter</td></tr><tr><td rowspan="1" colspan="1" style="text-align:right;vertical-align:top;">
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<b>Target Category:</b>
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</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Binding</td></tr><tr><td rowspan="1" colspan="1" style="text-align:right;vertical-align:top;">
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<b>Method of detection:</b>
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</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">PET</td></tr><tr><td rowspan="1" colspan="1" style="text-align:right;vertical-align:top;">
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<b>Source of signal:</b>
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</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"><sup>18</sup>F</td></tr><tr><td rowspan="1" colspan="1" style="text-align:right;vertical-align:top;">
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<b>Activation:</b>
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</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">No</td></tr><tr><td rowspan="1" colspan="1" style="text-align:right;vertical-align:top;">
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<b>Studies:</b>
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</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<ul class="simple-list"><li class="half_rhythm"><div>
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<img alt="Checkbox" src="/corehtml/pmc/css/bookshelf/2.26/img/studies.checkbox.png" />
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<i>In vitro</i>
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</div></li></ul>
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<ul class="simple-list"><li class="half_rhythm"><div>
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<img alt="Checkbox" src="/corehtml/pmc/css/bookshelf/2.26/img/studies.checkbox.png" /> Rodents
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</div></li></ul>
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</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Click on the above structure for additional information in <a href="http://pubchem.ncbi.nlm.nih.gov" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">PubChem</a>.</td></tr></tbody></table></div></div></article></div><div id="jr-scripts"><script src="/corehtml/pmc/jatsreader/ptpmc_3.22/js/libs.min.js"> </script><script src="/corehtml/pmc/jatsreader/ptpmc_3.22/js/jr.min.js"> </script></div></div>
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