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<meta name="robots" content="INDEX,FOLLOW,NOARCHIVE" /><meta name="citation_inbook_title" content="Molecular Imaging and Contrast Agent Database (MICAD) [Internet]" /><meta name="citation_title" content="[111In]-Ethylenedicysteine-murine anti-phosphotyrosine antibody" /><meta name="citation_publisher" content="National Center for Biotechnology Information (US)" /><meta name="citation_date" content="2009/04/06" /><meta name="citation_author" content="Arvind Chopra" /><meta name="citation_pmid" content="20641197" /><meta name="citation_fulltext_html_url" content="https://www.ncbi.nlm.nih.gov/books/NBK22989/" /><link rel="schema.DC" href="http://purl.org/DC/elements/1.0/" /><meta name="DC.Title" content="[111In]-Ethylenedicysteine-murine anti-phosphotyrosine antibody" /><meta name="DC.Type" content="Text" /><meta name="DC.Publisher" content="National Center for Biotechnology Information (US)" /><meta name="DC.Contributor" content="Arvind Chopra" /><meta name="DC.Date" content="2009/04/06" /><meta name="DC.Identifier" content="https://www.ncbi.nlm.nih.gov/books/NBK22989/" /><meta name="description" content="The overexpression or constitutive activation of non-receptor tyrosine kinase (TK) such as Src- and Bcr-Abl is one of the several mechanisms known to initiate and participate in the progression and metastasis of cancer (1, 2). 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<div class="pre-content"><div><div class="bk_prnt"><p class="small">NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.</p><p>Molecular Imaging and Contrast Agent Database (MICAD) [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2004-2013. </p></div><div class="iconblock clearfix whole_rhythm no_top_margin bk_noprnt"><a class="img_link icnblk_img" title="Table of Contents Page" href="/books/n/micad/"><img class="source-thumb" src="/corehtml/pmc/pmcgifs/bookshelf/thumbs/th-micad-lrg.png" alt="Cover of Molecular Imaging and Contrast Agent Database (MICAD)" height="100px" width="80px" /></a><div class="icnblk_cntnt eight_col"><h2>Molecular Imaging and Contrast Agent Database (MICAD) [Internet].</h2><a data-jig="ncbitoggler" href="#__NBK22989_dtls__">Show details</a><div style="display:none" class="ui-widget" id="__NBK22989_dtls__"><div>Bethesda (MD): <a href="https://www.ncbi.nlm.nih.gov/" ref="pagearea=page-banner&targetsite=external&targetcat=link&targettype=publisher">National Center for Biotechnology Information (US)</a>; 2004-2013.</div></div><div class="half_rhythm"><ul class="inline_list"><li style="margin-right:1em"><a class="bk_cntns" href="/books/n/micad/">Contents</a></li></ul></div><div class="bk_noprnt"><form method="get" action="/books/n/micad/" id="bk_srch"><div class="bk_search"><label for="bk_term" class="offscreen_noflow">Search term</label><input type="text" title="Search this book" id="bk_term" name="term" value="" data-jig="ncbiclearbutton" /> <input type="submit" class="jig-ncbibutton" value="Search this book" submit="false" style="padding: 0.1em 0.4em;" /></div></form></div></div><div class="icnblk_cntnt two_col"><div class="pagination bk_noprnt"><a class="active page_link prev" href="/books/n/micad/Bomproamide111In/" title="Previous page in this title">< Prev</a><a class="active page_link next" href="/books/n/micad/AntiuPARpep111In/" title="Next page in this title">Next ></a></div></div></div></div></div>
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<div class="main-content lit-style" itemscope="itemscope" itemtype="http://schema.org/CreativeWork"><div class="meta-content fm-sec"><h1 id="_NBK22989_"><span class="title" itemprop="name">[<sup>111</sup>In]-Ethylenedicysteine-murine anti-phosphotyrosine antibody</span></h1><div itemprop="alternativeHeadline" class="subtitle whole_rhythm"><sup>111</sup>In-EC-APT</div><p class="contrib-group"><span itemprop="author">Arvind Chopra</span>, PhD.</p><a data-jig="ncbitoggler" href="#__NBK22989_ai__" style="border:0;text-decoration:none">Author Information and Affiliations</a><div style="display:none" class="ui-widget" id="__NBK22989_ai__"><div class="contrib half_rhythm"><span itemprop="author">Arvind Chopra</span>, PhD<div class="affiliation small">National Center for Biotechnology Information, NLM, NIH, Bethesda, MD 20894<div><span class="email-label">Email: </span><a href="mailto:dev@null" data-email="vog.hin.mln.ibcn@dacim" class="oemail">vog.hin.mln.ibcn@dacim</a></div></div></div></div><p class="small">Created: <span itemprop="datePublished">March 12, 2009</span>; Last Update: <span itemprop="dateModified">April 6, 2009</span>.</p></div><div class="jig-ncbiinpagenav body-content whole_rhythm" data-jigconfig="allHeadingLevels: ['h2'],smoothScroll: false" itemprop="text"><div id="ECAPT111In.T1" class="table"><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK22989/table/ECAPT111In.T1/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ECAPT111In.T1_lrgtbl__"><table><tbody><tr><td rowspan="1" colspan="1" style="text-align:right;vertical-align:top;">
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<b>Chemical name:</b>
|
||
</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">[<sup>111</sup>In]-Ethylenedicysteine-murine anti-phosphotyrosine antibody<br /></td><td rowspan="9" colspan="1" style="text-align:left;vertical-align:middle;"></td></tr><tr><td rowspan="1" colspan="1" style="text-align:right;vertical-align:top;">
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<b>Abbreviated name:</b>
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</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"><sup>111</sup>In-EC-APT<br /></td></tr><tr><td rowspan="1" colspan="1" style="text-align:right;vertical-align:top;">
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<b>Synonym:</b>
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||
</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td></tr><tr><td rowspan="1" colspan="1" style="text-align:right;vertical-align:top;">
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<b>Agent Category:</b>
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</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Antibody</td></tr><tr><td rowspan="1" colspan="1" style="text-align:right;vertical-align:top;">
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<b>Target:</b>
|
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</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Bcr-Abl tyrosine kinase</td></tr><tr><td rowspan="1" colspan="1" style="text-align:right;vertical-align:top;">
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<b>Target Category:</b>
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</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Enzyme</td></tr><tr><td rowspan="1" colspan="1" style="text-align:right;vertical-align:top;">
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<b>Method of detection:</b>
|
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</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Single-photon emission computed tomography (SPECT); gamma planar imaging</td></tr><tr><td rowspan="1" colspan="1" style="text-align:right;vertical-align:top;">
|
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<b>Source of signal / contrast:</b>
|
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</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"><sup>111</sup>In</td></tr><tr><td rowspan="1" colspan="1" style="text-align:right;vertical-align:top;">
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<b>Activation:</b>
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</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">No</td></tr><tr><td rowspan="1" colspan="1" style="text-align:right;vertical-align:top;">
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<b>Studies:</b>
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</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<ul class="simple-list"><li class="half_rhythm"><div>
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<img alt="Checkbox" src="/corehtml/pmc/css/bookshelf/2.26/img/studies.checkbox.png" /> Rodents
|
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</div></li></ul>
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</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Click here for the <a href="/entrez/viewer.fcgi?db=Nucleotide&dopt=GenBank&val=33318779" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">nucleotide</a> and <a href="/sites/entrez?dopt=GenPept&cmd=Retrieve&db=protein&list_uids=148673890" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">protein</a> sequence of mouse (<i>Mus musculus</i>) tyrosine kinase.</td></tr></tbody></table></div></div><div id="ECAPT111In.Background"><h2 id="_ECAPT111In_Background_">Background</h2><p>[<a href="/sites/entrez?Db=pubmed&Cmd=DetailsSearch&Term=Bcr+Abl+tyrosine+kinase" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">PubMed</a>]</p><p>The overexpression or constitutive activation of non-receptor tyrosine kinase (TK) such as Src- and Bcr-Abl is one of the several mechanisms known to initiate and participate in the progression and metastasis of cancer (<a class="bk_pop" href="#ECAPT111In.REF.1" data-bk-pop-others="ECAPT111In.REF.2">1, 2</a>). Because of their role in the development of different neoplasms, small-molecule drugs such as imatinib, dasatinib, and others that block TK activity by inhibiting ATP binding to the enzyme are often used to treat patients suffering from this disease (<a class="bk_pop" href="#ECAPT111In.REF.3" data-bk-pop-others="ECAPT111In.REF.4">3, 4</a>). Because several different TK blockers are either under development or are being evaluated in <a href="http://clinicaltrials.gov/ct2/results?term=tyrosine+kinase+inhibitors" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">clinical trials</a> to treat cancers, it is important to be able to screen patients to determine which TK inhibitor is likely to result in a good prognosis for an individual (<a class="bk_pop" href="#ECAPT111In.REF.5">5</a>). Although invasive procedures such as biopsies are routinely used to determine the efficacy of an anti-cancer treatment, a noninvasive technique such as imaging would probably be preferred to evaluate drug activity during early stages of the treatment.</p><p>Wu et al. envisioned that antibodies labeled with a radionuclide and directed toward an intracellular non-receptor TK could be used for the noninvasive determination of drug efficacy (<a class="bk_pop" href="#ECAPT111In.REF.5">5</a>). The investigators evaluated an ethylenedicysteine (EC)-murine anti-phosphotyrosine (APT) antibody labeled with radioactive indium (<sup>111</sup>In) (<sup>111</sup>In-EC-APT) to image the Bcr-Abl TK, which is known to be upregulated and to promote chronic myeloid leukemia (<a class="bk_pop" href="#ECAPT111In.REF.6">6</a>), in a mouse xenograft tumor model. The radiolabeled antibody (Ab) was also used to investigate tumor imaging changes in the animals after treatment with imatinib.</p></div><div id="ECAPT111In.Synthesis"><h2 id="_ECAPT111In_Synthesis_">Synthesis</h2><p>[<a href="/sites/entrez?Db=pubmed&Cmd=DetailsSearch&Term=labeled+Bcr+Abl+anti+tyrosine+kinase+antibody+synthesis" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">PubMed</a>]</p><p>The synthesis of <sup>111</sup>In-EC-APT was described in detail by Wu et al. (<a class="bk_pop" href="#ECAPT111In.REF.5">5</a>). The various biological reagents used for the studies and described in this chapter, including the control (anti-phospho-Bcr-Abl Ab) and the murine APT 4G10 Abs, were obtained from commercial sources. EC was conjugated to the APT Ab, murine immunoglobulin G<sub>1</sub> (IgG<sub>1</sub>), anti-phospho-Bcr-Abl Ab, and bovine serum albumin (BSA) with sulfo-<i>N</i>-hydroxysuccinimide (NHS) and 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride (EDC) as the coupling agents.</p><p>For the conjugation of EC, the various bioreagents were respectively incubated with a mixture of EC, NHS, and EDC for 17 h at room temperature. The purification and final percent yield of the respective EC-conjugated bioreagents and the ratio of chelating agent per antibody molecule were not reported. For labeling with <sup>111</sup>In, the radionuclide was mixed with the respective EC-conjugated bioreagent to obtain <sup>111</sup>In-EC-BSA, <sup>111</sup>In-EC-IgG<sub>1</sub>, <sup>111</sup>In-EC-Bcr-Abl, and <sup>111</sup>In-EC-APT. Purification of the radiolabeled bioreagents was not reported. Radiochemical purity of the <sup>111</sup>In-labeled biochemicals was reported to be >95%, as determined with thin-layer chromatography. The specific activity and stability of the various labeled bioreagents were not reported.</p></div><div id="ECAPT111In.In_Vitro_Studies_Tes"><h2 id="_ECAPT111In_In_Vitro_Studies_Tes_"><i>In Vitro</i> Studies: Testing in Cells and Tissues</h2><p>[<a href="/entrez/query.fcgi?cmd=PureSearch&db=pubmed&details_term=%22SUBSTANCENAME%22%5BSubstance%20Name%5D%20AND%20in%20vitro" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">PubMed</a>]</p><p>No references are currently available.</p></div><div id="ECAPT111In.Animal_Studies"><h2 id="_ECAPT111In_Animal_Studies_">Animal Studies</h2><div id="ECAPT111In.Rodents"><h3>Rodents</h3><p>[<a href="/sites/entrez?Db=pubmed&Cmd=DetailsSearch&Term=111In+EC+APT+Rodentia" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">PubMed</a>]</p><p>Tumor imaging studies were performed with immunodeficient mice bearing K562 cell tumors, a human chronic myeloid leukemia cell line that constitutively expresses activated Bcr-Abl TK (<a class="bk_pop" href="#ECAPT111In.REF.5">5</a>). The mice were divided into five groups, each consisting of five animals. The first group received <sup>111</sup>In-EC-BSA to visualize normal blood flow in the tumor; the second group received <sup>111</sup>In-EC-APT to determine tumor specificity of the labeled Ab, and the third group was treated with imatinib for 3 days before the <sup>111</sup>In-EC-APT injection and during the imaging study (a total of 4 or 5 d). Two other groups of animals received either <sup>111</sup>In-EC-IgG<sub>1</sub> or <sup>111</sup>In-EC-Bcr-Abl to serve as the negative and positive controls, respectively. Images were acquired at various time points up to 48 h after the radiobiochemical injection.</p><p>Determination of the tumor/non-tumor count densities after planar scintigraphy revealed that there was an increased uptake of <sup>111</sup>In-EC-APT by the tumors compared with <sup>111</sup>In-EC-BSA (<a class="bk_pop" href="#ECAPT111In.REF.5">5</a>). Mice treated with imatinib showed a reduced (<i>P</i> < 0.05) <sup>111</sup>In-EC-APT uptake. At 48 h after treatment with the radiotracers, one animal from each group was subjected to single-photon emission computed tomography-computed tomography (SPECT-CT), which produces a dynamic image (for details see Wu et al. (<a class="bk_pop" href="#ECAPT111In.REF.5">5</a>)) of the combined functional and structural features of the tumor, to measure the precise phosphorylation status of the tumors. Results obtained with SPECT-CT were similar to those obtained with planar scintigraphy. The tumor/normal muscle count ratios (TMR) were determined for all radiotracers used to treat the animals (<a class="bk_pop" href="#ECAPT111In.REF.5">5</a>). The TMR ratios were reported to be 1.5, 1.9, 4.0, and 6.0 for <sup>111</sup>In-EC-BSA (used to visualize blood flow), <sup>111</sup>In-EC-IgG<sub>1</sub> (negative control), <sup>111</sup>In-EC-APT, and <sup>111</sup>In-EC-Bcl-Abl (positive control), respectively.</p><p>With results obtained from this study (<a class="bk_pop" href="#ECAPT111In.REF.5">5</a>), the investigators concluded that imaging could be used to select a specific TK inhibitor for the treatment of certain cancer and to predict the treatment response in a clinical setting (<a class="bk_pop" href="#ECAPT111In.REF.5">5</a>).</p></div><div id="ECAPT111In.Other_NonPrimate_Mam"><h3>Other Non-Primate Mammals</h3><p>[<a href="/sites/entrez?Db=pubmed&Cmd=DetailsSearch&Term=111In+EC+APT+Non+Primate+Mammal+studies" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">PubMed</a>]</p><p>No references are currently available.</p></div><div id="ECAPT111In.NonHuman_Primates"><h3>Non-Human Primates</h3><p>[<a href="/sites/entrez?Db=pubmed&Cmd=DetailsSearch&Term=111In+EC+APT+Non+Human+Primate+studies" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">PubMed</a>]</p><p>No references are currently available.</p></div></div><div id="ECAPT111In.Human_Studies"><h2 id="_ECAPT111In_Human_Studies_">Human Studies</h2><p>[<a href="/sites/entrez?Db=pubmed&Cmd=DetailsSearch&Term=111In+EC+APT+Human+studies" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">PubMed</a>]</p><p>No references are currently available.</p></div><div id="ECAPT111In.Supplemental_Informa"><h2 id="_ECAPT111In_Supplemental_Informa_">Supplemental Information</h2><p>[<a href="/books/n/micad/disclaimer/">Disclaimers</a>]</p></div><div id="ECAPT111In.References"><h2 id="_ECAPT111In_References_">References</h2><dl class="temp-labeled-list"><dt>1.</dt><dd><div class="bk_ref" id="ECAPT111In.REF.1">Finn R.S. Targeting Src in breast cancer. <span><span class="ref-journal">Ann Oncol. </span>2008;<span class="ref-vol">19</span>(8):1379–86.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/18487549" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 18487549</span></a>]</div></dd><dt>2.</dt><dd><div class="bk_ref" id="ECAPT111In.REF.2">Pytel D., Sliwinski T., Poplawski T., Ferriola D., Majsterek I. Tyrosine kinase blockers: new hope for successful cancer therapy. <span><span class="ref-journal">Anticancer Agents Med Chem. </span>2009;<span class="ref-vol">9</span>(1):66–76.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/19149483" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 19149483</span></a>]</div></dd><dt>3.</dt><dd><div class="bk_ref" id="ECAPT111In.REF.3">Muller B.A. Imatinib and its successors--how modern chemistry has changed drug development. <span><span class="ref-journal">Curr Pharm Des. </span>2009;<span class="ref-vol">15</span>(2):120–33.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/19149608" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 19149608</span></a>]</div></dd><dt>4.</dt><dd><div class="bk_ref" id="ECAPT111In.REF.4">Gora-Tybor J., Robak T. Targeted drugs in chronic myeloid leukemia. <span><span class="ref-journal">Curr Med Chem. </span>2008;<span class="ref-vol">15</span>(29):3036–51.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/19075651" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 19075651</span></a>]</div></dd><dt>5.</dt><dd><div class="bk_ref" id="ECAPT111In.REF.5">Wu, J.Y., D.J. Yang, L.S. Angelo, S. Kohanim, and R. Kurzrock, Molecular imaging of Bcr-Abl phosphokinase in a xenograft model. Mol Cancer Ther, 2009. [<a href="/pmc/articles/PMC2679515/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC2679515</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/19258427" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 19258427</span></a>]</div></dd><dt>6.</dt><dd><div class="bk_ref" id="ECAPT111In.REF.6">O'Hare T., Deininger M.W. Toward a cure for chronic myeloid leukemia. <span><span class="ref-journal">Clin Cancer Res. </span>2008;<span class="ref-vol">14</span>(24):7971–4.</span> [<a href="/pmc/articles/PMC2614298/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC2614298</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/19088011" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 19088011</span></a>]</div></dd></dl></div><div id="bk_toc_contnr"></div></div></div>
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<div class="post-content"><div><div class="half_rhythm"><a href="/books/about/copyright/">Copyright Notice</a></div><div class="small"><span class="label">Bookshelf ID: NBK22989</span><span class="label">PMID: <a href="https://pubmed.ncbi.nlm.nih.gov/20641197" title="PubMed record of this page" ref="pagearea=meta&targetsite=entrez&targetcat=link&targettype=pubmed">20641197</a></span></div><div style="margin-top:2em" class="bk_noprnt"><a class="bk_cntns" href="/books/n/micad/">Contents</a><div class="pagination bk_noprnt"><a class="active page_link prev" href="/books/n/micad/Bomproamide111In/" title="Previous page in this title">< Prev</a><a class="active page_link next" href="/books/n/micad/AntiuPARpep111In/" title="Next page in this title">Next ></a></div></div></div></div>
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<div xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"></div><div class="portlet"><div class="portlet_head"><div class="portlet_title"><h3><span>Views</span></h3></div><a name="Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="PDF_download" id="Shutter"></a></div><div class="portlet_content"><ul xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="simple-list"><li><a href="/books/NBK22989/?report=reader">PubReader</a></li><li><a href="/books/NBK22989/?report=printable">Print View</a></li><li><a data-jig="ncbidialog" href="#_ncbi_dlg_citbx_NBK22989" data-jigconfig="width:400,modal:true">Cite this Page</a><div id="_ncbi_dlg_citbx_NBK22989" style="display:none" title="Cite this Page"><div class="bk_tt">Chopra A. [111In]-Ethylenedicysteine-murine anti-phosphotyrosine antibody. 2009 Mar 12 [Updated 2009 Apr 6]. In: Molecular Imaging and Contrast Agent Database (MICAD) [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2004-2013. <span class="bk_cite_avail"></span></div></div></li><li><a href="/books/NBK22989/pdf/Bookshelf_NBK22989.pdf">PDF version of this page</a> (123K)</li><li><a href="/books/n/micad/toc/bin/micad.csv">MICAD summary (CSV file)</a></li></ul></div></div><div class="portlet"><div class="portlet_head"><div class="portlet_title"><h3><span>In this page</span></h3></div><a name="Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="page-toc" id="Shutter"></a></div><div class="portlet_content"><ul xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="simple-list"><li><a href="#ECAPT111In.Background" ref="log$=inpage&link_id=inpage">Background</a></li><li><a href="#ECAPT111In.Synthesis" ref="log$=inpage&link_id=inpage">Synthesis</a></li><li><a href="#ECAPT111In.In_Vitro_Studies_Tes" ref="log$=inpage&link_id=inpage"><i>In Vitro</i> Studies: Testing in Cells and Tissues</a></li><li><a href="#ECAPT111In.Animal_Studies" ref="log$=inpage&link_id=inpage">Animal Studies</a></li><li><a href="#ECAPT111In.Human_Studies" ref="log$=inpage&link_id=inpage">Human Studies</a></li><li><a href="#ECAPT111In.Supplemental_Informa" ref="log$=inpage&link_id=inpage">Supplemental Information</a></li><li><a href="#ECAPT111In.References" ref="log$=inpage&link_id=inpage">References</a></li></ul></div></div><div class="portlet"><div class="portlet_head"><div class="portlet_title"><h3><span>Search MICAD</span></h3></div><a name="Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="source-application" id="Shutter"></a></div><div class="portlet_content"><form xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" name="frmSearch" method="get" action="/books/NBK5330/" id="frmSearch"><script type="text/javascript" src="/corehtml/pmc//js/bookshelf/micad.js">/**/</script><label class="offscreen_noflow" for="txtfield">Search term</label><input id="txtfield" type="text" name="f1_term" size="22" onKeyPress="KeyPress('micad',event,'/books/NBK5330/','')" /><button name="f1_search" type="submit">Go</button><button onclick="this.form.reset();" type="reset">Clear</button><p><b>Limit my Search:</b></p><div class="clearfix"><label for="detection">Method of detection:</label><div class="right"><select name="detection" id="detection" style="width:200px"><option value="" selected="selected">Any</option><option value="(MRI OR "Magnetic resonance imaging" OR MRS)">MRI</option><option value="Multimodal">Multimodal imaging</option><option value="Optical">Optical imaging</option><option value="PET">PET</option><option value="Photoacoustic">Photoacoustic imaging</option><option value="(SPECT OR planar)">SPECT</option><option value="Ultrasound">Ultrasound</option><option value="(x-ray OR ct)">X-ray, CT</option></select></div></div><div class="clearfix"><label for="signal">Source of signal/contrast:</label><div class="right"><select name="signal" id="signal" style="width:200px"><option value="" selected="selected">Any</option><optgroup label="MRI agents"><option value="(Copper OR Cu)">Copper</option><option value="(Europium OR Eu3+)">Europium</option><option value="(Fluorine OR 19F)">Fluorine</option><option value="(Gadolinium OR Gd3+)">Gadolinium</option><option value=""Hyperpolarized 13C"">Hyperpolarized 13C</option><option value=""Iron oxide"">Iron oxide</option><option value=""Nitroxide radicals"">Nitroxide radicals</option><option value="(Oxygen OR 17O)">Oxygen</option><option value="Thulium">Thulium</option></optgroup><optgroup label="Multimodal agents"><option value="((Gadolinium OR Gd3+) AND Optical)">Gadolinium and optical</option><option value="((Gadolinium OR Gd3+) AND (Gold OR Au))">Gadolinium and Gold</option><option value="("Iron oxide" AND (64Cu OR 124I OR 111In))">Iron oxide and
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value="("Nitrogen 13" OR 13N)">Nitrogen-13</option><option value="("Yttrium 86" OR 86Y)">Yttrium-86</option><option value="("Zirconium 89" OR 89Zr)">Zirconium-89</option></optgroup><optgroup label="Photoacoustic agents"><option value="(Gold OR Au)">Gold</option><option value="("Indocyanine green" OR ICG)">Indocyanine green</option></optgroup><optgroup label="SPECT radionuclides"><option value="(Gallium-67 OR 67Ga)">Gallium-67</option><option value="("Indium 111" OR 111In)">Indium-111</option><option value="("Iodine 123" OR "Iodine 125" OR "Iodine 131" OR 123I OR 125I OR 131I)">Iodine-123, 125, 131</option><option value="("Lutetium 177" OR 177Lu)">Lutetium-177</option><option value="(Rhenium OR 186Re OR 188Re)">Rhenium</option><option value="("Technetium 99m" OR 99mTc)">Technetium-99m</option><option value="("Tellurium 125m" OR 125mTe)">Tellurium-125m</option></optgroup><optgroup label="Ultrasound agents"><option value="Microbubbles">Microbubbles</option><option value="Nanobubbles">Nanobubbles</option></optgroup><optgroup label="X-ray and CT agents"><option value="(Bismuth OR Bi)">Bismuth</option><option value="(Gold OR Au)">Gold</option><option value="Iodine">Iodine</option></optgroup></select></div></div><div class="clearfix"><label for="agent">Agent Category:</label><div class="right"><select name="agent" id="agent" style="width:200px"><option value="" selected="selected">Any</option><option value="(antibody OR trastuzumab OR immunoglobulin)">Antibodies</option><option value="(bacteria OR bacteriophage OR coli)">Bacteria</option><option value="cell">Cells</option><option value="(compound OR "amino acid" OR "folic acid" OR "cage molecule" OR carbohydrate OR copolymers OR polymer OR "small molecule" OR macromolecule OR triiodobenzoate OR estradiol OR glycosaminoglycan)">Compounds</option><option value="ligand">Ligands</option><option value="(lipid OR liposome OR liposomes">Lipids</option><option value="metal">Metal</option><option 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/><label for="__micad_btn_6">Any</label></div></form><form xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" name="frmGo" method="get" action="javascript:alert('frmGo:_@action_was_not_set')" id="frmGo"><input name="term" value="." type="hidden" /></form></div></div><div class="portlet"><div class="portlet_head"><div class="portlet_title"><h3><span>Related information</span></h3></div><a name="Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="discovery_db_links" id="Shutter"></a></div><div class="portlet_content"><ul><li class="brieflinkpopper"><a class="brieflinkpopperctrl" href="/books/?Db=pmc&DbFrom=books&Cmd=Link&LinkName=books_pmc_refs&IdsFromResult=1503504" ref="log$=recordlinks">PMC</a><div class="brieflinkpop offscreen_noflow">PubMed Central citations</div></li><li class="brieflinkpopper"><a class="brieflinkpopperctrl" href="/books/?Db=pubmed&DbFrom=books&Cmd=Link&LinkName=books_pubmed_refs&IdsFromResult=1503504" ref="log$=recordlinks">PubMed</a><div class="brieflinkpop offscreen_noflow">Links to PubMed</div></li></ul></div></div><div class="portlet"><div class="portlet_head"><div class="portlet_title"><h3><span>Similar articles in PubMed</span></h3></div><a name="Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="PBooksDiscovery_RA" id="Shutter"></a></div><div class="portlet_content"><ul><li class="brieflinkpopper two_line"><a class="brieflinkpopperctrl" href="/pubmed/19258427" ref="ordinalpos=1&linkpos=1&log$=relatedarticles&logdbfrom=pubmed">Molecular imaging of Bcr-Abl phosphokinase in a xenograft model.</a><span class="source">[Mol Cancer Ther. 2009]</span><div class="brieflinkpop offscreen_noflow">Molecular imaging of Bcr-Abl phosphokinase in a xenograft model.<div class="brieflinkpopdesc"><em xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="author">Wu JY, Yang DJ, Angelo LS, Kohanim S, Kurzrock R. </em><em xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="cit">Mol Cancer Ther. 2009 Mar; 8(3):703-10. Epub 2009 Mar 3.</em></div></div></li><li class="brieflinkpopper two_line"><a class="brieflinkpopperctrl" href="/pubmed/23700641" ref="ordinalpos=1&linkpos=2&log$=relatedreviews&logdbfrom=pubmed"><span xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="invert">Review</span> (111)In/(68)Ga-Labeled anti-epidermal growth factor receptor, native chemical ligation cyclized Affibody Z(HER2:342min).</a><span class="source">[Molecular Imaging and Contrast...]</span><div class="brieflinkpop offscreen_noflow"><span xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="invert">Review</span> (111)In/(68)Ga-Labeled anti-epidermal growth factor receptor, native chemical ligation cyclized Affibody Z(HER2:342min).<div class="brieflinkpopdesc"><em xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="author">Chopra A. </em><em xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="cit">Molecular Imaging and Contrast Agent Database (MICAD). 2004</em></div></div></li><li class="brieflinkpopper two_line"><a class="brieflinkpopperctrl" href="/pubmed/20641910" ref="ordinalpos=1&linkpos=3&log$=relatedreviews&logdbfrom=pubmed"><span xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="invert">Review</span> (111)In conjugated to benzyl-diethylenetriaminepentaacetic acid-human epidermal growth factor.</a><span class="source">[Molecular Imaging and Contrast...]</span><div class="brieflinkpop offscreen_noflow"><span xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="invert">Review</span> (111)In conjugated to benzyl-diethylenetriaminepentaacetic acid-human epidermal growth factor.<div class="brieflinkpopdesc"><em xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="author">Chopra A. </em><em xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="cit">Molecular Imaging and Contrast Agent Database (MICAD). 2004</em></div></div></li><li class="brieflinkpopper two_line"><a class="brieflinkpopperctrl" href="/pubmed/23638490" ref="ordinalpos=1&linkpos=4&log$=relatedreviews&logdbfrom=pubmed"><span xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="invert">Review</span> (111)In-Labeled anti-epidermal growth factor receptor Affibody PEP09239.</a><span class="source">[Molecular Imaging and Contrast...]</span><div class="brieflinkpop offscreen_noflow"><span xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="invert">Review</span> (111)In-Labeled anti-epidermal growth factor receptor Affibody PEP09239.<div class="brieflinkpopdesc"><em xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="author">Chopra A. </em><em xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="cit">Molecular Imaging and Contrast Agent Database (MICAD). 2004</em></div></div></li><li class="brieflinkpopper two_line"><a class="brieflinkpopperctrl" href="/pubmed/20806449" ref="ordinalpos=1&linkpos=5&log$=relatedreviews&logdbfrom=pubmed"><span xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="invert">Review</span> (111)In-Labeled chimeric monoclonal antibody, ch806, targeting the epidermal growth factor receptor deletion variant de2-7 (EGFRvIII).</a><span class="source">[Molecular Imaging and Contrast...]</span><div class="brieflinkpop offscreen_noflow"><span xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="invert">Review</span> (111)In-Labeled chimeric monoclonal antibody, ch806, targeting the epidermal growth factor receptor deletion variant de2-7 (EGFRvIII).<div class="brieflinkpopdesc"><em xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="author">Chopra A. </em><em xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="cit">Molecular Imaging and Contrast Agent Database (MICAD). 2004</em></div></div></li></ul><a class="seemore" href="/sites/entrez?db=pubmed&cmd=link&linkname=pubmed_pubmed_reviews&uid=20641197" ref="ordinalpos=1&log$=relatedreviews_seeall&logdbfrom=pubmed">See reviews...</a><a class="seemore" href="/sites/entrez?db=pubmed&cmd=link&linkname=pubmed_pubmed&uid=20641197" ref="ordinalpos=1&log$=relatedarticles_seeall&logdbfrom=pubmed">See all...</a></div></div><div class="portlet"><div 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offscreen_noflow">[111In]-Ethylenedicysteine-murine anti-phosphotyrosine antibody - Molecular Imaging and Contrast Agent Database (MICAD)<div class="brieflinkpopdesc"></div></div><div class="tertiary"></div></li><li class="ra_rcd ralinkpopper two_line"><a class="htb ralinkpopperctrl" ref="log$=activity&linkpos=2" href="/portal/utils/pageresolver.fcgi?recordid=67d6481dcde49f3df760a59d">[111In]-DOTA-Aminohexanoyl-[D-Phe6,Leu-NHCH2CH2CH313,desMet14] BBN[6-14] - Molec...</a><div class="ralinkpop offscreen_noflow">[111In]-DOTA-Aminohexanoyl-[D-Phe6,Leu-NHCH2CH2CH313,desMet14] BBN[6-14] - Molecular Imaging and Contrast Agent Database (MICAD)<div class="brieflinkpopdesc"></div></div><div class="tertiary"></div></li><li class="ra_rcd ralinkpopper two_line"><a class="htb ralinkpopperctrl" ref="log$=activity&linkpos=3" href="/portal/utils/pageresolver.fcgi?recordid=67d6481c67c23b31e0374f86">[111In]5-[(3aR,6S,6aS)-2-Oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-6-yl]p...</a><div class="ralinkpop offscreen_noflow">[111In]5-[(3aR,6S,6aS)-2-Oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-6-yl]pentanoic acid - Molecular Imaging and Contrast Agent Database (MICAD)<div class="brieflinkpopdesc"></div></div><div class="tertiary"></div></li><li class="ra_rcd ralinkpopper two_line"><a class="htb ralinkpopperctrl" ref="log$=activity&linkpos=4" href="/portal/utils/pageresolver.fcgi?recordid=67d6481acde49f3df760983f">111In - Molecular Imaging and Contrast Agent Database (MICAD)</a><div class="ralinkpop offscreen_noflow">111In - Molecular Imaging and Contrast Agent Database (MICAD)<div class="brieflinkpopdesc"></div></div><div class="tertiary"></div></li><li class="ra_rcd ralinkpopper two_line"><a class="htb ralinkpopperctrl" ref="log$=activity&linkpos=5" href="/portal/utils/pageresolver.fcgi?recordid=67d648192f30673f7b7b6969">SPECT - Molecular Imaging and Contrast Agent Database (MICAD)</a><div class="ralinkpop offscreen_noflow">SPECT - Molecular Imaging and Contrast 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