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<title>64Cu-Labeled Lys40(1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid)NH2–conjugated exendin-4 - Molecular Imaging and Contrast Agent Database (MICAD) - NCBI Bookshelf</title>
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<meta name="robots" content="INDEX,FOLLOW,NOARCHIVE" /><meta name="citation_inbook_title" content="Molecular Imaging and Contrast Agent Database (MICAD) [Internet]" /><meta name="citation_title" content="64Cu-Labeled Lys40(1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid)NH2–conjugated exendin-4" /><meta name="citation_publisher" content="National Center for Biotechnology Information (US)" /><meta name="citation_date" content="2012/02/23" /><meta name="citation_author" content="Arvind Chopra" /><meta name="citation_pmid" content="22379636" /><meta name="citation_fulltext_html_url" content="https://www.ncbi.nlm.nih.gov/books/NBK84303/" /><link rel="schema.DC" href="http://purl.org/DC/elements/1.0/" /><meta name="DC.Title" content="64Cu-Labeled Lys40(1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid)NH2–conjugated exendin-4" /><meta name="DC.Type" content="Text" /><meta name="DC.Publisher" content="National Center for Biotechnology Information (US)" /><meta name="DC.Contributor" content="Arvind Chopra" /><meta name="DC.Date" content="2012/02/23" /><meta name="DC.Identifier" content="https://www.ncbi.nlm.nih.gov/books/NBK84303/" /><meta name="description" content="Autoimmune processes and other environmental factors that destroy β-cells located in the pancreatic islet cells are known to promote the development of insulin-dependent diabetes mellitus (type 1 diabetes) in individuals genetically predisposed to the disease (1). 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<div class="pre-content"><div><div class="bk_prnt"><p class="small">NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.</p><p>Molecular Imaging and Contrast Agent Database (MICAD) [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2004-2013. </p></div><div class="iconblock clearfix whole_rhythm no_top_margin bk_noprnt"><a class="img_link icnblk_img" title="Table of Contents Page" href="/books/n/micad/"><img class="source-thumb" src="/corehtml/pmc/pmcgifs/bookshelf/thumbs/th-micad-lrg.png" alt="Cover of Molecular Imaging and Contrast Agent Database (MICAD)" height="100px" width="80px" /></a><div class="icnblk_cntnt eight_col"><h2>Molecular Imaging and Contrast Agent Database (MICAD) [Internet].</h2><a data-jig="ncbitoggler" href="#__NBK84303_dtls__">Show details</a><div style="display:none" class="ui-widget" id="__NBK84303_dtls__"><div>Bethesda (MD): <a href="https://www.ncbi.nlm.nih.gov/" ref="pagearea=page-banner&targetsite=external&targetcat=link&targettype=publisher">National Center for Biotechnology Information (US)</a>; 2004-2013.</div></div><div class="half_rhythm"><ul class="inline_list"><li style="margin-right:1em"><a class="bk_cntns" href="/books/n/micad/">Contents</a></li></ul></div><div class="bk_noprnt"><form method="get" action="/books/n/micad/" id="bk_srch"><div class="bk_search"><label for="bk_term" class="offscreen_noflow">Search term</label><input type="text" title="Search this book" id="bk_term" name="term" value="" data-jig="ncbiclearbutton" /> <input type="submit" class="jig-ncbibutton" value="Search this book" submit="false" style="padding: 0.1em 0.4em;" /></div></form></div></div><div class="icnblk_cntnt two_col"><div class="pagination bk_noprnt"><a class="active page_link prev" href="/books/n/micad/HisCu64/" title="Previous page in this title">< Prev</a><a class="active page_link next" href="/books/n/micad/TrasBFCs64Cu/" title="Next page in this title">Next ></a></div></div></div></div></div>
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<div class="main-content lit-style" itemscope="itemscope" itemtype="http://schema.org/CreativeWork"><div class="meta-content fm-sec"><h1 id="_NBK84303_"><span class="title" itemprop="name"><sup>64</sup>Cu-Labeled Lys<sup>40</sup>(1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid)NH<sub>2</sub>–conjugated exendin-4</span></h1><div itemprop="alternativeHeadline" class="subtitle whole_rhythm"> [<sup>64</sup>Cu](Lys<sup>40</sup>(DOTA)NH<sub>2</sub>)Exendin-4</div><p class="contrib-group"><span itemprop="author">Arvind Chopra</span>, PhD.</p><a data-jig="ncbitoggler" href="#__NBK84303_ai__" style="border:0;text-decoration:none">Author Information and Affiliations</a><div style="display:none" class="ui-widget" id="__NBK84303_ai__"><div class="contrib half_rhythm"><span itemprop="author">Arvind Chopra</span>, PhD<div class="affiliation small">National Center for Biotechnology Information, NLM, Bethesda, MD 20894<div><span class="email-label">Email: </span><a href="mailto:dev@null" data-email="vog.hin.mln.ibcn@dacim" class="oemail">vog.hin.mln.ibcn@dacim</a></div></div></div></div><p class="small">Created: <span itemprop="datePublished">January 25, 2012</span>; Last Update: <span itemprop="dateModified">February 23, 2012</span>.</p></div><div class="jig-ncbiinpagenav body-content whole_rhythm" data-jigconfig="allHeadingLevels: ['h2'],smoothScroll: false" itemprop="text"><div id="DOTAExe64Cu.T.nc_chemical_name64culabele" class="table"><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK84303/table/DOTAExe64Cu.T.nc_chemical_name64culabele/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__DOTAExe64Cu.T.nc_chemical_name64culabele_lrgtbl__"><table><tbody><tr><td rowspan="1" colspan="1" style="text-align:right;vertical-align:top;">
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<b>Chemical name:</b>
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</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"><sup>64</sup>Cu-Labeled Lys<sup>40</sup>(1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid)NH<sub>2</sub>–conjugated exendin-4<br /></td><td rowspan="9" colspan="1" style="text-align:center;vertical-align:middle;"></td></tr><tr><td rowspan="1" colspan="1" style="text-align:right;vertical-align:top;">
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<b>Abbreviated name:</b>
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</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">[<sup>64</sup>Cu](Lys<sup>40</sup>(DOTA)NH<sub>2</sub>)Exendin-4<br /></td></tr><tr><td rowspan="1" colspan="1" style="text-align:right;vertical-align:top;">
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<b>Synonym:</b>
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</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td></tr><tr><td rowspan="1" colspan="1" style="text-align:right;vertical-align:top;">
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<b>Agent Category:</b>
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</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Peptide</td></tr><tr><td rowspan="1" colspan="1" style="text-align:right;vertical-align:top;">
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<b>Target:</b>
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</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Glucagon-like peptide 1 receptor (GLP-1R)</td></tr><tr><td rowspan="1" colspan="1" style="text-align:right;vertical-align:top;">
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<b>Target Category:</b>
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</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Receptor</td></tr><tr><td rowspan="1" colspan="1" style="text-align:right;vertical-align:top;">
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<b>Method of detection:</b>
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</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Positron emission tomography (PET)</td></tr><tr><td rowspan="1" colspan="1" style="text-align:right;vertical-align:top;">
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<b>Source of signal / contrast:</b>
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</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"><sup>64</sup>Cu</td></tr><tr><td rowspan="1" colspan="1" style="text-align:right;vertical-align:top;">
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<b>Activation:</b>
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</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">No</td></tr><tr><td rowspan="1" colspan="1" style="text-align:right;vertical-align:top;">
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<b>Studies:</b>
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</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<ul class="simple-list"><li class="half_rhythm"><div>
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<img alt="Checkbox" src="/corehtml/pmc/css/bookshelf/2.26/img/studies.checkbox.png" />
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<i>In vitro</i>
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</div></li><li class="half_rhythm"><div>
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<img alt="Checkbox" src="/corehtml/pmc/css/bookshelf/2.26/img/studies.checkbox.png" /> Rodents
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</div></li></ul>
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</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Structure not available in <a href="http://pubchem.ncbi.nlm.nih.gov/" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">PubChem</a>.</td></tr></tbody></table></div></div><div id="DOTAExe64Cu.Background"><h2 id="_DOTAExe64Cu_Background_">Background</h2><p>[<a href="/pubmed?term=Exendin%204" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">PubMed</a>]</p><p>Autoimmune processes and other environmental factors that destroy β-cells located in the pancreatic islet cells are known to promote the development of insulin-dependent diabetes mellitus (type 1 diabetes) in individuals genetically predisposed to the disease (<a class="bk_pop" href="#DOTAExe64Cu.REF.1">1</a>). Due to this destruction, the net mass of the β-cells in the islet cells of the pancreas is reduced, which leads to decreased production of insulin in the individual, and the maintenance of blood glucose at proper physiological levels is impaired. Type 2 diabetes is the most common form of the disease and is primarily caused by insulin resistance as a consequence of low insulin secretion by the β-cells. This form of diabetes can often be corrected with exercise, diet control, and/or medication (<a class="bk_pop" href="#DOTAExe64Cu.REF.2">2</a>). Upon diagnosis of diabetes, it is important to determine the individual's β-cell mass (BCM) or volume to devise a successful treatment regimen for the condition (<a class="bk_pop" href="#DOTAExe64Cu.REF.3">3</a>). Changes in the BCM during the onset of diabetes is poorly understood, and only an indirect method that measures the amount of stimulated insulin secretion by the pancreas is used to quantify the BCM in humans (<a class="bk_pop" href="#DOTAExe64Cu.REF.4">4</a>). However, the β-cells appear to have a reserved capacity to produce insulin, so the use of insulin secretion as a determinant of BCM is of limited value (<a class="bk_pop" href="#DOTAExe64Cu.REF.4">4</a>).</p><p>As an alternative to determine insulin secretion to quantify BCM, investigators have evaluated the use of noninvasive positron emission tomography (PET) imaging techniques to determine the BCM in rats with the use of <sup>11</sup>C- or <sup>18</sup>F-labeled dihydrotetrabenazine, which is an antagonist of the vesicular monoamine transporter type 2 (VMAT2) in the islet cells (<a class="bk_pop" href="#DOTAExe64Cu.REF.5">5</a>). Careful evaluation of results obtained with the VMAT2 antagonists has revealed that a large proportion of these radiolabeled compounds tend to reside in the exocrine pancreas, indicating that these radiotracers are not suitable for the determination of BCM with PET imaging (<a class="bk_pop" href="#DOTAExe64Cu.REF.6">6</a>). Recently, some G-protein–coupled receptors (e.g., the glucagon-like peptide 1 (GLP 1) receptor (GLP-1R)), which show a selective location in the β-cells compared to the surrounding exocrine pancreatic cells, were identified by database mining and immunohistochemical staining of pancreatic tissue (<a class="bk_pop" href="#DOTAExe64Cu.REF.6" data-bk-pop-others="DOTAExe64Cu.REF.7 DOTAExe64Cu.REF.8">6-8</a>). On the basis of these observations and the known involvement of GLP-1R in β-cell function and biology (for details, see Baggio and Drucker (<a class="bk_pop" href="#DOTAExe64Cu.REF.9">9</a>)), this receptor was identified as a possible target of radiolabeled probes that can be used to quantify the BCM. Although GLP-1 is the natural ligand for the GLP-1R, a major drawback of using this peptide to measure the BCM is that it is rapidly inactivated (half-life, ~2 min) by proteolytic enzymes while in circulation. As a consequence, investigators identified and have used radiolabeled Exendin-4 or its analogs (Exendin is a peptide of 39 amino acids that has a 54% homology with GLP-1, acts as an agonist of the GLP-1R, and is not inactivated by proteolytic enzymes) for the measurement of BCM with noninvasive molecular imaging techniques (<a class="bk_pop" href="#DOTAExe64Cu.REF.6" data-bk-pop-others="DOTAExe64Cu.REF.8">6, 8</a>). Connolly et al. evaluated the use of <sup>64</sup>Cu-labeled Lys<sup>40</sup>(1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid)NH<sub>2</sub>–conjugated exendin-4 ([<sup>64</sup>Cu](Lys<sup>40</sup>(DOTA)NH<sub>2</sub>)Exendin-4) for the <i>in vivo</i> imaging and measurement of the BCM in rats and investigated its biodistribution in these animals (<a class="bk_pop" href="#DOTAExe64Cu.REF.6">6</a>).</p><div id="DOTAExe64Cu.Related_Resource_Links"><h3>Related Resource Links</h3><p>Related chapters in <a href="/books?term=BCM%5BAll%20Fields%5D%20AND%20micad%5Bbook%5D&cmd=DetailsSearch" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">MICAD</a></p><p><a href="http://clinicaltrials.gov/ct2/results?term=GLP-1R" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">Clinical trials</a> related to GLP-1R</p><p><a href="/gene/2740" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">Gene information</a> regarding human GLP-1R (Gene ID: 2740)</p><p><a href="http://omim.org/entry/138030" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">Glucagon-like peptide 1</a> in Online Mendelian Inheritance in Man Database (OMIM)</p><p><a href="http://www.genome.jp/dbget-bin/www_bget?mmu:14652" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">Mouse GLP-1R</a> in Kyoto Encyclopedia of Genes and Genomes Database (KEGG)</p><p>GLP-1R agonists for the treatment of type II diabetes: <a href="http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=751747da-7c1f-41ad-b1a6-a6d920f70599" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">Exenatide</a> and <a href="http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=5a9ef4ea-c76a-4d34-a604-27c5b505f5a4" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">Liraglutide</a></p><p>
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<a href="http://www.diabetes.org/" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">American Diabetes Association</a>
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</p></div></div><div id="DOTAExe64Cu.Synthesis"><h2 id="_DOTAExe64Cu_Synthesis_">Synthesis</h2><p>[<a href="/pubmed?term=%5B(64)Cu%5D%20(Lys(40)(DOTA)NH(2))Exendin-4%20synthesis" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">PubMed</a>]</p><p>(Lys<sup>40</sup>(DOTA)NH<sub>2</sub>)Exendin-4 was obtained from a commercial source and labeled with <sup>64</sup>Cu as described by Connolly et al. (<a class="bk_pop" href="#DOTAExe64Cu.REF.6">6</a>). The labeled peptide was purified on a C<sub>18</sub> light SepPak column with high-performance liquid chromatography. The radiochemical purity of the labeled peptide was determined to be 94.2 ± 0.9% with a specific activity of 13.22 ± 6.62 TBq/mmol (357 ± 179 Ci/mmol; <i>n</i> = 5 experiments). The stability of [<sup>64</sup>Cu](Lys<sup>40</sup>(DOTA)NH<sub>2</sub>)Exendin-4 was not reported.</p></div><div id="DOTAExe64Cu.In_Vitro_Studies_Testing_in"><h2 id="_DOTAExe64Cu_In_Vitro_Studies_Testing_in_"><i>In Vitro</i> Studies: Testing in Cells and Tissues</h2><p>[<a href="/pubmed?term=%5B%2864%29Cu%5D%20%28Lys%2840%29%28DOTA%29NH%282%29%29Exendin-4%20in%20vitro&cmd=DetailsSearch" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">PubMed</a>]</p><p>A commercially available kit that quantifies the amount of cyclic AMP produced by the activation of a receptor was used with Chinese hamster ovary cells that express the human GLP-1R to determine the agonistic potency of (Lys<sup>40</sup>(DOTA)NH<sub>2</sub>)Exendin-4 (used as a proof of concept molecule for the study) (<a class="bk_pop" href="#DOTAExe64Cu.REF.6">6</a>). The EC<sub>50</sub> of this molecule was determined to be 0.41 nM; however, the EC<sub>50</sub> values of GLP-1 and Exendin-4 were not reported.</p><p>In another study, normal and diabetic human and non-human primate pancreas sections were subjected to immunohistochemical analysis with appropriate antibodies to detect the presence of the GLP-1R in the organ (<a class="bk_pop" href="#DOTAExe64Cu.REF.6">6</a>). The fluorescent signal was detected only in islet cells of the normal specimens, and sections obtained from the diabetic organ generated a very low signal in these cells. This indicated that there was a low level of the GLP-1R in the diabetic specimens and suggested that the receptor could be a suitable target for the noninvasive imaging of β-cells.</p><p><i>Ex vivo</i> autoradiography of pancreas sections obtained from a rat at 60 min after tail vein injection of [<sup>64</sup>Cu](Lys<sup>40</sup>(DOTA)NH<sub>2</sub>)Exendin-4 showed a distinct signal pattern in multiple areas of the tissue, and this was presumed to be generated by radioactivity bound to the islet cells (<a class="bk_pop" href="#DOTAExe64Cu.REF.6">6</a>). The same section was immunostained to detect insulin (insulin is stained only where the β-cells are present), and a staining pattern similar to that observed with [<sup>64</sup>Cu](Lys<sup>40</sup>(DOTA)NH<sub>2</sub>)Exendin-4 was apparent. The two images were merged, and the autoradiographic and the immunostaining signals were reported to originate from the same location in the specimen, indicating that the distribution of radioactivity corresponded to the distribution of the islet cells. Autoradiography of pancreas sections obtained from a rat administered with unlabeled Exendin(9-39) 10 min before the injection of [<sup>64</sup>Cu](Lys<sup>40</sup>(DOTA)NH<sub>2</sub>)Exendin-4 showed a complete absence of signal, suggesting that the uptake of radioactivity was blocked in this specimen and that the radiolabeled peptide had binding specificity for the GLP-1R. It was also reported that autoradiography of pancreas sections from <a href="http://www.criver.com/en-us/prodserv/bytype/resmodover/resmod/pages/zdfrat.aspx" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">Zucker ZDF rats</a> (these rodents are the animal model for human type 2 diabetes and show loss of β-cells with progression of the disease) injected with [<sup>64</sup>Cu](Lys<sup>40</sup>(DOTA)NH<sub>2</sub>)Exendin-4 showed very little uptake of radioactivity compared with pancreas sections obtained from control Zucker ZCL rat (<a class="bk_pop" href="#DOTAExe64Cu.REF.6">6</a>). These results indicated that the tracer was suitable for the determination of any changes in the BCM of the animals.</p></div><div id="DOTAExe64Cu.Animal_Studies"><h2 id="_DOTAExe64Cu_Animal_Studies_">Animal Studies</h2><div id="DOTAExe64Cu.Rodents"><h3>Rodents</h3><p>[<a href="/pubmed?term=%5B(64)Cu%5D%20(Lys(40)(DOTA)NH(2))Exendin-4%20rodentia" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">PubMed</a>]</p><p>The biodistribution of [<sup>64</sup>Cu](Lys<sup>40</sup>(DOTA)NH<sub>2</sub>)Exendin-4 was studied in normal and <a href="http://www.sigmaaldrich.com/catalog/ProductDetail.do?D7=0&N5=SEARCH_CONCAT_PNO%7CBRAND_KEY&N4=85882%7CFLUKA&N25=0&QS=ON&F=SPEC" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">streptozotocine</a> (STZ)-treated Sprague-Dawley rats (<i>n</i> = 3 animals/group) (<a class="bk_pop" href="#DOTAExe64Cu.REF.6">6</a>). Immediately prior to initiation of the study, the blood glucose levels of animals from both groups were determined. The rodents were injected with 1.1 MBq (30 μCi) of the tracer through the tail vein and euthanized 60 min later to determine the amount of radioactivity accumulated in the organs of interest. Data were reported as standard uptake values (SUV) corresponding to the injected dose and weight of each animal. The blood glucose level of the normal animals was significantly lower (98.0 ± 12.2 mg/dL; <i>P</i> = 0.02) than that of the STZ-treated rats (442.3 ± 42.7 mg/dL), indicating that the latter group of rodents had a complete onset of diabetes. Both groups of rats showed high accumulation of radioactivity in the kidneys (48.3 ± 5.5 SUV and 27.6 ± 5.1 SUV for the control and STZ-treated animals, respectively), indicating that the tracer was excreted primarily through the urinary system. Uptake of radioactivity in the pancreas of the STZ-treated animals (0.1 ± 0.01 SUV) was significantly lower (<i>P</i> = 0.001) than that observed in the organ of the control rats (0.3 ± 0.02 SUV). All other organs obtained from the control animals showed uptake values between 0.03 ± 0.02 SUV (blood) and 0.7 ± 0.2 SUV (liver), and the STZ-treated group showed a similar trend with tracer accumulation values between 0.2 ± 0.04 SUV (blood) and 0.6 ± 0.05 SUV (liver).</p><p>To confirm the uptake of [<sup>64</sup>Cu](Lys<sup>40</sup>(DOTA)NH<sub>2</sub>)Exendin-4 in the pancreas of the rats, dynamic PET images were acquired from two anesthetized animals (<a class="bk_pop" href="#DOTAExe64Cu.REF.6">6</a>). The rodents were first injected with [<sup>11</sup>C]methionine to visualize the pancreatic region in the abdomen of the animals (this tracer is known to accumulate primarily in the pancreas (<a class="bk_pop" href="#DOTAExe64Cu.REF.6">6</a>)). PET scans were performed for 45 min, and images obtained with the <sup>11</sup>C probe clearly showed the outline of the pancreas of the animals. Subsequently, the same animals were injected with [<sup>64</sup>Cu](Lys<sup>40</sup>(DOTA)NH<sub>2</sub>)Exendin-4, and PET scans were acquired for 60 min post injection. To confirm the accumulation of the Exendin tracer in the pancreas, images obtained from the two separate scans were merged using appropriate software as described by Connolly et al. (<a class="bk_pop" href="#DOTAExe64Cu.REF.6">6</a>). In the merged image, however, the radioactivity taken up by the kidneys from the <sup>64</sup>Cu-labeled peptide interfered with the image of the pancreas due to the close proximity of the organs in the abdominal cavity of the rats. As a result, the investigators could not clearly visualize the uptake of label in the pancreas.</p><p>From these studies, the investigators concluded that [<sup>64</sup>Cu](Lys<sup>40</sup>(DOTA)NH<sub>2</sub>)Exendin-4 bound specifically to the GLP-1R under <i>in vitro</i> conditions. To confirm this observation <i>in vivo</i> and to quantify the BCM in the pancreas, however, similar studies will have to be performed in large animals (<a class="bk_pop" href="#DOTAExe64Cu.REF.6">6</a>).</p></div><div id="DOTAExe64Cu.Other_NonPrimate_Mammals"><h3>Other Non-Primate Mammals</h3><p>[<a href="/pubmed?term=%5B%2864%29Cu%5D%20%28Lys%2840%29%28DOTA%29NH%282%29%29Exendin-4%20Other%20Non-Primate%20Mammals&cmd=DetailsSearch" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">PubMed</a>]</p><p>No publication is currently available.</p></div><div id="DOTAExe64Cu.NonHuman_Primates"><h3>Non-Human Primates</h3><p>[<a href="/pubmed?term=%5B%2864%29Cu%5D%20%28Lys%2840%29%28DOTA%29NH%282%29%29Exendin-4%20Non-Human%20Primates&cmd=DetailsSearch" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">PubMed</a>]</p><p>No publication is currently available.</p></div></div><div id="DOTAExe64Cu.Human_Studies"><h2 id="_DOTAExe64Cu_Human_Studies_">Human Studies</h2><p>[<a href="/pubmed?term=17138746%5Buid%5D&cmd=DetailsSearch" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">PubMed</a>]</p><p>No publication is currently available.</p></div><div id="DOTAExe64Cu.Supplemental_Information"><h2 id="_DOTAExe64Cu_Supplemental_Information_">Supplemental Information</h2><p>[<a href="/books/n/micad/disclaimer/">Disclaimers</a>]</p><p>No information is currently available.</p></div><div id="DOTAExe64Cu.References"><h2 id="_DOTAExe64Cu_References_">References</h2><dl class="temp-labeled-list"><dt>1.</dt><dd><div class="bk_ref" id="DOTAExe64Cu.REF.1">Concannon P., Rich S.S., Nepom G.T.
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<em>Genetics of type 1A diabetes.</em>
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||
<span><span class="ref-journal">N Engl J Med. </span>2009;<span class="ref-vol">360</span>(16):1646–54.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/19369670" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 19369670</span></a>]</div></dd><dt>2.</dt><dd><div class="bk_ref" id="DOTAExe64Cu.REF.2">Krentz A.J., Bailey C.J.
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<em>Oral antidiabetic agents: current role in type 2 diabetes mellitus.</em>
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||
<span><span class="ref-journal">Drugs. </span>2005;<span class="ref-vol">65</span>(3):385–411.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/15669880" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 15669880</span></a>]</div></dd><dt>3.</dt><dd><div class="bk_ref" id="DOTAExe64Cu.REF.3">Ritzel R.A.
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<em>Therapeutic approaches based on beta-cell mass preservation and/or regeneration.</em>
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||
<span><span class="ref-journal">Front Biosci. </span>2009;<span class="ref-vol">14</span>:1835–50.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/19273167" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 19273167</span></a>]</div></dd><dt>4.</dt><dd><div class="bk_ref" id="DOTAExe64Cu.REF.4">Harris P.E., Ferrara C., Barba P., Polito T., Freeby M., Maffei A.
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||
<em>VMAT2 gene expression and function as it applies to imaging beta-cell mass.</em>
|
||
<span><span class="ref-journal">J Mol Med (Berl). </span>2008;<span class="ref-vol">86</span>(1):5–16.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/17665159" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 17665159</span></a>]</div></dd><dt>5.</dt><dd><div class="bk_ref" id="DOTAExe64Cu.REF.5">Kung M.P., Hou C., Lieberman B.P., Oya S., Ponde D.E., Blankemeyer E., Skovronsky D., Kilbourn M.R., Kung H.F.
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<em>In vivo imaging of beta-cell mass in rats using 18F-FP-(+)-DTBZ: a potential PET ligand for studying diabetes mellitus.</em>
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||
<span><span class="ref-journal">J Nucl Med. </span>2008;<span class="ref-vol">49</span>(7):1171–6.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/18552132" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 18552132</span></a>]</div></dd><dt>6.</dt><dd><div class="bk_ref" id="DOTAExe64Cu.REF.6">Connolly B.M., Vanko A., McQuade P., Guenther I., Meng X., Rubins D., Waterhouse R., Hargreaves R., Sur C., Hostetler E.
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<em>Ex Vivo Imaging of Pancreatic Beta Cells using a Radiolabeled GLP-1 Receptor Agonist.</em>
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<span><span class="ref-journal">Mol Imaging Biol. </span>2012;<span class="ref-vol">14</span>(1):79–87.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/21394533" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 21394533</span></a>]</div></dd><dt>7.</dt><dd><div class="bk_ref" id="DOTAExe64Cu.REF.7">Cline G.W., Zhao X., Jakowski A.B., Soeller W.C., Treadway J.L.
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<em>Islet-selectivity of G-protein coupled receptor ligands evaluated for PET imaging of pancreatic beta-cell mass.</em>
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<span><span class="ref-journal">Biochem Biophys Res Commun. </span>2011;<span class="ref-vol">412</span>(3):413–8.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/21820405" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 21820405</span></a>]</div></dd><dt>8.</dt><dd><div class="bk_ref" id="DOTAExe64Cu.REF.8">Wang Y., Lim K., Normandin M., Zhao X., Cline G.W., Ding Y.S.
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<em>Synthesis and evaluation of [(18)F]exendin (9-39) as a potential biomarker to measure pancreatic beta-cell mass.</em>
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<span><span class="ref-journal">Nucl Med Biol. </span>2011;<span class="ref-vol">39</span>(2):167–176.</span> [<a href="/pmc/articles/PMC4484741/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC4484741</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/22033026" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 22033026</span></a>]</div></dd><dt>9.</dt><dd><div class="bk_ref" id="DOTAExe64Cu.REF.9">Baggio L.L., Drucker D.J.
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<em>Biology of incretins: GLP-1 and GIP.</em>
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<span><span class="ref-journal">Gastroenterology. </span>2007;<span class="ref-vol">132</span>(6):2131–57.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/17498508" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 17498508</span></a>]</div></dd></dl></div><div id="bk_toc_contnr"></div></div></div>
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<div class="post-content"><div><div class="half_rhythm"><a href="/books/about/copyright/">Copyright Notice</a></div><div class="small"><span class="label">Bookshelf ID: NBK84303</span><span class="label">PMID: <a href="https://pubmed.ncbi.nlm.nih.gov/22379636" title="PubMed record of this page" ref="pagearea=meta&targetsite=entrez&targetcat=link&targettype=pubmed">22379636</a></span></div><div style="margin-top:2em" class="bk_noprnt"><a class="bk_cntns" href="/books/n/micad/">Contents</a><div class="pagination bk_noprnt"><a class="active page_link prev" href="/books/n/micad/HisCu64/" title="Previous page in this title">< Prev</a><a class="active page_link next" href="/books/n/micad/TrasBFCs64Cu/" title="Next page in this title">Next ></a></div></div></div></div>
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<div xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"></div><div class="portlet"><div class="portlet_head"><div class="portlet_title"><h3><span>Views</span></h3></div><a name="Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="PDF_download" id="Shutter"></a></div><div class="portlet_content"><ul xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="simple-list"><li><a href="/books/NBK84303/?report=reader">PubReader</a></li><li><a href="/books/NBK84303/?report=printable">Print View</a></li><li><a data-jig="ncbidialog" href="#_ncbi_dlg_citbx_NBK84303" data-jigconfig="width:400,modal:true">Cite this Page</a><div id="_ncbi_dlg_citbx_NBK84303" style="display:none" title="Cite this Page"><div class="bk_tt">Chopra A. 64Cu-Labeled Lys40(1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid)NH2–conjugated exendin-4. 2012 Jan 25 [Updated 2012 Feb 23]. In: Molecular Imaging and Contrast Agent Database (MICAD) [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2004-2013. <span class="bk_cite_avail"></span></div></div></li><li><a href="/books/NBK84303/pdf/Bookshelf_NBK84303.pdf">PDF version of this page</a> (145K)</li><li><a href="/books/n/micad/toc/bin/micad.csv">MICAD summary (CSV file)</a></li></ul></div></div><div class="portlet"><div class="portlet_head"><div class="portlet_title"><h3><span>In this page</span></h3></div><a name="Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="page-toc" id="Shutter"></a></div><div class="portlet_content"><ul xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="simple-list"><li><a href="#DOTAExe64Cu.Background" ref="log$=inpage&link_id=inpage">Background</a></li><li><a href="#DOTAExe64Cu.Synthesis" ref="log$=inpage&link_id=inpage">Synthesis</a></li><li><a href="#DOTAExe64Cu.In_Vitro_Studies_Testing_in" ref="log$=inpage&link_id=inpage"><i>In Vitro</i> Studies: Testing in Cells and Tissues</a></li><li><a href="#DOTAExe64Cu.Animal_Studies" ref="log$=inpage&link_id=inpage">Animal Studies</a></li><li><a href="#DOTAExe64Cu.Human_Studies" ref="log$=inpage&link_id=inpage">Human Studies</a></li><li><a href="#DOTAExe64Cu.Supplemental_Information" ref="log$=inpage&link_id=inpage">Supplemental Information</a></li><li><a href="#DOTAExe64Cu.References" ref="log$=inpage&link_id=inpage">References</a></li></ul></div></div><div class="portlet"><div class="portlet_head"><div class="portlet_title"><h3><span>Search MICAD</span></h3></div><a name="Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="source-application" id="Shutter"></a></div><div class="portlet_content"><form xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" name="frmSearch" method="get" action="/books/NBK5330/" id="frmSearch"><script type="text/javascript" src="/corehtml/pmc//js/bookshelf/micad.js">/**/</script><label class="offscreen_noflow" for="txtfield">Search term</label><input id="txtfield" type="text" name="f1_term" size="22" onKeyPress="KeyPress('micad',event,'/books/NBK5330/','')" /><button name="f1_search" type="submit">Go</button><button onclick="this.form.reset();" type="reset">Clear</button><p><b>Limit my Search:</b></p><div class="clearfix"><label for="detection">Method of detection:</label><div class="right"><select name="detection" id="detection" style="width:200px"><option value="" selected="selected">Any</option><option value="(MRI OR "Magnetic resonance imaging" OR MRS)">MRI</option><option value="Multimodal">Multimodal imaging</option><option value="Optical">Optical imaging</option><option value="PET">PET</option><option value="Photoacoustic">Photoacoustic imaging</option><option value="(SPECT OR planar)">SPECT</option><option value="Ultrasound">Ultrasound</option><option value="(x-ray OR ct)">X-ray, CT</option></select></div></div><div class="clearfix"><label for="signal">Source of signal/contrast:</label><div class="right"><select name="signal" id="signal" style="width:200px"><option value="" selected="selected">Any</option><optgroup label="MRI agents"><option value="(Copper OR Cu)">Copper</option><option value="(Europium OR Eu3+)">Europium</option><option value="(Fluorine OR 19F)">Fluorine</option><option value="(Gadolinium OR Gd3+)">Gadolinium</option><option value=""Hyperpolarized 13C"">Hyperpolarized 13C</option><option value=""Iron oxide"">Iron oxide</option><option value=""Nitroxide radicals"">Nitroxide radicals</option><option value="(Oxygen OR 17O)">Oxygen</option><option value="Thulium">Thulium</option></optgroup><optgroup label="Multimodal agents"><option value="((Gadolinium OR Gd3+) AND Optical)">Gadolinium and optical</option><option value="((Gadolinium OR Gd3+) AND (Gold OR Au))">Gadolinium and Gold</option><option value="("Iron oxide" AND (64Cu OR 124I OR 111In))">Iron oxide and
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radionuclides</option><option value="(Perfluorocarbon AND (Europium OR Eu3+))">Perfluorocarbon and
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europium</option><option value="(166Ho OR 67Ga OR 68Ga OR 123I OR 124I OR 125I)">Radionuclides</option></optgroup><optgroup label="Optical agents"><option value="("Fluorescent dyes" OR protein)">Fluorescent dyes or proteins</option><option value=""Luminescent agents"">Luminescent agents</option><option value="(Metals OR Metal OR Gold OR Au)">Metals (Au)</option><option value="Nanotubes">Nanotubes</option><option value=""Quantum dots"">Quantum dots</option></optgroup><optgroup label="PET radionuclides"><option value="("Arsenic 74" OR 74As)">Arsenic-74</option><option value="("Bromine 76" OR 76Br)">Bromine-76</option><option value="("Carbon 11" OR 11C)">Carbon-11</option><option value="(Copper-60 OR Copper-61 OR Copper-62 OR Copper-64 OR 60Cu OR 61Cu OR 62Cu OR 64Cu)">Copper-60, 61, 62, 64</option><option value="("Fluorine 18" OR 18F)">Fluorine-18</option><option value="(Gallium-68 OR 68Ga)">Gallium-68</option><option value="("Iodine 124" OR 124I)">Iodine-124</option><option value="("Nitrogen 13" OR 13N)">Nitrogen-13</option><option value="("Yttrium 86" OR 86Y)">Yttrium-86</option><option value="("Zirconium 89" OR 89Zr)">Zirconium-89</option></optgroup><optgroup label="Photoacoustic agents"><option value="(Gold OR Au)">Gold</option><option value="("Indocyanine green" OR ICG)">Indocyanine green</option></optgroup><optgroup label="SPECT radionuclides"><option value="(Gallium-67 OR 67Ga)">Gallium-67</option><option value="("Indium 111" OR 111In)">Indium-111</option><option value="("Iodine 123" OR "Iodine 125" OR "Iodine 131" OR 123I OR 125I OR 131I)">Iodine-123, 125, 131</option><option value="("Lutetium 177" OR 177Lu)">Lutetium-177</option><option value="(Rhenium OR 186Re OR 188Re)">Rhenium</option><option value="("Technetium 99m" OR 99mTc)">Technetium-99m</option><option value="("Tellurium 125m" OR 125mTe)">Tellurium-125m</option></optgroup><optgroup label="Ultrasound agents"><option value="Microbubbles">Microbubbles</option><option value="Nanobubbles">Nanobubbles</option></optgroup><optgroup label="X-ray and CT agents"><option value="(Bismuth OR Bi)">Bismuth</option><option value="(Gold OR Au)">Gold</option><option value="Iodine">Iodine</option></optgroup></select></div></div><div class="clearfix"><label for="agent">Agent Category:</label><div class="right"><select name="agent" id="agent" style="width:200px"><option value="" selected="selected">Any</option><option value="(antibody OR trastuzumab OR immunoglobulin)">Antibodies</option><option value="(bacteria OR bacteriophage OR coli)">Bacteria</option><option value="cell">Cells</option><option value="(compound OR "amino acid" OR "folic acid" OR "cage molecule" OR carbohydrate OR copolymers OR polymer OR "small molecule" OR macromolecule OR triiodobenzoate OR estradiol OR glycosaminoglycan)">Compounds</option><option value="ligand">Ligands</option><option value="(lipid OR liposome OR liposomes">Lipids</option><option value="metal">Metal</option><option value="(nanoparticle OR nanoparticles OR nanotubes OR "iron oxide")">Nanoparticles</option><option value="(siRNA OR "nucleic acid" OR oligonucleotide)">Nucleic acids</option><option value="peptide">Peptides</option><option value="polyeptide">Polyeptides</option><option value="(protein OR albumin OR chemokin OR immunoprotein OR luciferase OR albumin)">Proteins</option><option value="(virus OR adenovirus)">Viruses</option></select></div></div><div class="clearfix"><label for="target">Target Category:</label><div class="right"><select name="target" id="target" style="width:200px"><option value="" selected="selected">Any</option><option value="acceptor">Acceptors</option><option value=""adhesion molecule"">Adhesion molecules</option><option value="(antigen OR antibody-antigen)">Antigens</option><option value="(enzyme OR enzymes OR enzyme-substrate)">Enzymes</option><option value="(lipids OR lipophilic cation)">Lipids</option><option value="(receptor OR receptors OR receptor-ligand OR receptor-antibody OR antibody-receptor)">Receptors</option><option value="transporter">Transporters</option><option value="non-targeted">Non-targeted</option><option value=""nucleic acid"">Nucleic acids</option><option value="(non-targeted OR "unknown binding site")">Others</option></select></div></div><div><input id="__micad_btn_1" type="radio" name="stage" value="vitro" /><label for="__micad_btn_1"><i>In vitro</i></label><input id="__micad_btn_2" type="radio" name="stage" value="rodents" /><label for="__micad_btn_2">Rodents</label><input id="__micad_btn_3" type="radio" name="stage" value="mammals" /><label for="__micad_btn_3">Non-primate non-rodent mammals</label><br /><input id="__micad_btn_4" type="radio" name="stage" value="primates" /><label for="__micad_btn_4">Non-human primates</label><input id="__micad_btn_5" type="radio" name="stage" value="humans" /><label for="__micad_btn_5">Humans</label><input id="__micad_btn_6" type="radio" name="stage" value="any" checked="checked" /><label for="__micad_btn_6">Any</label></div></form><form xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" name="frmGo" method="get" action="javascript:alert('frmGo:_@action_was_not_set')" id="frmGo"><input name="term" value="." type="hidden" /></form></div></div><div class="portlet"><div class="portlet_head"><div class="portlet_title"><h3><span>Related information</span></h3></div><a name="Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="discovery_db_links" id="Shutter"></a></div><div class="portlet_content"><ul><li class="brieflinkpopper"><a class="brieflinkpopperctrl" href="/books/?Db=pmc&DbFrom=books&Cmd=Link&LinkName=books_pmc_refs&IdsFromResult=2811838" ref="log$=recordlinks">PMC</a><div class="brieflinkpop offscreen_noflow">PubMed Central citations</div></li><li class="brieflinkpopper"><a class="brieflinkpopperctrl" href="/books/?Db=pubmed&DbFrom=books&Cmd=Link&LinkName=books_pubmed_refs&IdsFromResult=2811838" ref="log$=recordlinks">PubMed</a><div class="brieflinkpop offscreen_noflow">Links to PubMed</div></li></ul></div></div><div class="portlet"><div class="portlet_head"><div class="portlet_title"><h3><span>Similar articles in PubMed</span></h3></div><a name="Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="PBooksDiscovery_RA" id="Shutter"></a></div><div class="portlet_content"><ul><li class="brieflinkpopper two_line"><a class="brieflinkpopperctrl" href="/pubmed/22624171" ref="ordinalpos=1&linkpos=1&log$=relatedreviews&logdbfrom=pubmed"><span xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="invert">Review</span> (18)F-Labeled exendin(9-39).</a><span class="source">[Molecular Imaging and Contrast...]</span><div class="brieflinkpop offscreen_noflow"><span xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="invert">Review</span> (18)F-Labeled exendin(9-39).<div class="brieflinkpopdesc"><em xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="author">Chopra A. </em><em xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="cit">Molecular Imaging and Contrast Agent Database (MICAD). 2004</em></div></div></li><li class="brieflinkpopper two_line"><a class="brieflinkpopperctrl" href="/pubmed/22439162" ref="ordinalpos=1&linkpos=2&log$=relatedreviews&logdbfrom=pubmed"><span xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="invert">Review</span> (64)Cu-Labeled 1,4,7-tris(acetic acid)-10-vinylsulfone-1,4,7,10-tetraazacyclododecane conjugated to Cys(40)-Exendin-4.</a><span class="source">[Molecular Imaging and Contrast...]</span><div class="brieflinkpop offscreen_noflow"><span xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="invert">Review</span> (64)Cu-Labeled 1,4,7-tris(acetic acid)-10-vinylsulfone-1,4,7,10-tetraazacyclododecane conjugated to Cys(40)-Exendin-4.<div class="brieflinkpopdesc"><em xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="author">Chopra A. </em><em xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="cit">Molecular Imaging and Contrast Agent Database (MICAD). 2004</em></div></div></li><li class="brieflinkpopper two_line"><a class="brieflinkpopperctrl" href="/pubmed/20641809" ref="ordinalpos=1&linkpos=3&log$=relatedreviews&logdbfrom=pubmed"><span xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="invert">Review</span> [(131)I]N-(6-amino-2,2,4-trimethylhexyl)-2-[(5-iodo(3-pyridyl))carbonylamino]-3-(2-napthyl)propanamide.</a><span class="source">[Molecular Imaging and Contrast...]</span><div class="brieflinkpop offscreen_noflow"><span xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="invert">Review</span> [(131)I]N-(6-amino-2,2,4-trimethylhexyl)-2-[(5-iodo(3-pyridyl))carbonylamino]-3-(2-napthyl)propanamide.<div class="brieflinkpopdesc"><em xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="author">Chopra A. </em><em xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="cit">Molecular Imaging and Contrast Agent Database (MICAD). 2004</em></div></div></li><li class="brieflinkpopper two_line"><a class="brieflinkpopperctrl" href="/pubmed/22457885" ref="ordinalpos=1&linkpos=4&log$=relatedreviews&logdbfrom=pubmed"><span xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="invert">Review</span> N-(2-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)ethyl)-4-[(18)F]-fluorobenzamide ([(18)F]FBEM) conjugated to EM3106B, an analog of glucagon-like peptide-1.</a><span class="source">[Molecular Imaging and Contrast...]</span><div class="brieflinkpop offscreen_noflow"><span xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="invert">Review</span> N-(2-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)ethyl)-4-[(18)F]-fluorobenzamide ([(18)F]FBEM) conjugated to EM3106B, an analog of glucagon-like peptide-1.<div class="brieflinkpopdesc"><em xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="author">Chopra A. </em><em xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="cit">Molecular Imaging and Contrast Agent Database (MICAD). 2004</em></div></div></li><li class="brieflinkpopper two_line"><a class="brieflinkpopperctrl" href="/pubmed/22457886" ref="ordinalpos=1&linkpos=5&log$=relatedreviews&logdbfrom=pubmed"><span xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="invert">Review</span> N-2-(4-[(18)F]-Fluorobenzamido)ethylmaleimide coupled to cysteine-tagged on the C- or N-terminal of exendin-4.</a><span class="source">[Molecular Imaging and Contrast...]</span><div class="brieflinkpop offscreen_noflow"><span xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="invert">Review</span> N-2-(4-[(18)F]-Fluorobenzamido)ethylmaleimide coupled to cysteine-tagged on the C- or N-terminal of exendin-4.<div class="brieflinkpopdesc"><em xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="author">Chopra A. </em><em xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="cit">Molecular Imaging and Contrast Agent Database (MICAD). 2004</em></div></div></li></ul><a class="seemore" href="/sites/entrez?db=pubmed&cmd=link&linkname=pubmed_pubmed_reviews&uid=22379636" ref="ordinalpos=1&log$=relatedreviews_seeall&logdbfrom=pubmed">See reviews...</a><a class="seemore" href="/sites/entrez?db=pubmed&cmd=link&linkname=pubmed_pubmed&uid=22379636" ref="ordinalpos=1&log$=relatedarticles_seeall&logdbfrom=pubmed">See all...</a></div></div><div class="portlet"><div class="portlet_head"><div class="portlet_title"><h3><span>Recent Activity</span></h3></div><a name="Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="recent_activity" id="Shutter"></a></div><div class="portlet_content"><div xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" id="HTDisplay" 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