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<script type="text/javascript" src="/corehtml/pmc/jatsreader/ptpmc_3.22/js/jr.boots.min.js"> </script><title>Cy7-(3S,7S)-26-Amino-5,13,20-trioxo-4,6,12,21-tetraazahexacosane-1,3,7,22-tetracarboxylic acid - Molecular Imaging and Contrast Agent Database (MICAD) - NCBI Bookshelf</title>
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<meta name="citation_inbook_title" content="Molecular Imaging and Contrast Agent Database (MICAD) [Internet]">
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<meta name="citation_title" content="Cy7-(3S,7S)-26-Amino-5,13,20-trioxo-4,6,12,21-tetraazahexacosane-1,3,7,22-tetracarboxylic acid">
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<meta name="citation_publisher" content="National Center for Biotechnology Information (US)">
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<meta name="citation_date" content="2013/04/04">
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<meta name="citation_author" content="Kam Leung">
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<meta name="DC.Title" content="Cy7-(3S,7S)-26-Amino-5,13,20-trioxo-4,6,12,21-tetraazahexacosane-1,3,7,22-tetracarboxylic acid">
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<meta name="description" content="Optical fluorescence imaging is increasingly used to monitor biological functions of specific targets in small animals (1-4). However, the intrinsic fluorescence of biomolecules poses a problem when fluorophores that absorb visible light (350–650 nm) are used. Near-infrared (NIR) fluorescence (650–1,000 nm) detection avoids the natural background fluorescence interference of biomolecules, providing a high contrast between target and background tissues in small animals. NIR fluorophores have a wider dynamic range and minimal background fluorescence as a result of reduced scattering compared with visible fluorescence detection. NIR fluorophores also have high sensitivity, attributable to low background fluorescence, and high extinction coefficients, which provide high quantum yields. The NIR region is also compatible with solid-state optical components, such as diode lasers and silicon detectors. NIR fluorescence imaging is a noninvasive alternative to radionuclide imaging in small animals (4, 5).">
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<meta name="og:description" content="Optical fluorescence imaging is increasingly used to monitor biological functions of specific targets in small animals (1-4). However, the intrinsic fluorescence of biomolecules poses a problem when fluorophores that absorb visible light (350–650 nm) are used. Near-infrared (NIR) fluorescence (650–1,000 nm) detection avoids the natural background fluorescence interference of biomolecules, providing a high contrast between target and background tissues in small animals. NIR fluorophores have a wider dynamic range and minimal background fluorescence as a result of reduced scattering compared with visible fluorescence detection. NIR fluorophores also have high sensitivity, attributable to low background fluorescence, and high extinction coefficients, which provide high quantum yields. The NIR region is also compatible with solid-state optical components, such as diode lasers and silicon detectors. NIR fluorescence imaging is a noninvasive alternative to radionuclide imaging in small animals (4, 5).">
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id="jr-fip-info-p"><a id="jr-fip-prev" class="wsprkl btn" title="Jump to previuos match">◀</a><button id="jr-fip-matches">no matches yet</button><a id="jr-fip-next" class="wsprkl btn" title="Jump to next match">▶</a></nav></nav></div><div id="jr-epub-interstitial" class="hidden"></div><div id="jr-content"><article data-type="main"><div class="main-content lit-style" itemscope="itemscope" itemtype="http://schema.org/CreativeWork"><div class="meta-content fm-sec"><div class="fm-sec"><h1 id="_NBK132021_"><span class="title" itemprop="name">Cy7-(3<i>S</i>,7<i>S</i>)-26-Amino-5,13,20-trioxo-4,6,12,21-tetraazahexacosane-1,3,7,22-tetracarboxylic acid</span></h1><div itemprop="alternativeHeadline" class="subtitle whole_rhythm">Cy7-3</div><p class="contribs">Leung K.</p><p class="fm-aai"><a href="#_NBK132021_pubdet_">Publication Details</a></p></div></div><div class="jig-ncbiinpagenav body-content whole_rhythm" data-jigconfig="allHeadingLevels: ['h2'],smoothScroll: false" itemprop="text"><div class="iconblock whole_rhythm clearfix ten_col table-wrap" id="figCy73Tncchemicalnamecy73s7s26amino5"><a href="/books/NBK132021/table/Cy7-3.T.nc_chemical_namecy73s7s26amino5/?report=objectonly" target="object" title="Table" class="img_link icnblk_img" rid-ob="figobCy73Tncchemicalnamecy73s7s26amino5"><img class="small-thumb" src="/corehtml/pmc/css/bookshelf/2.26/img/table-icon.gif" alt="Table Icon" /></a><div class="icnblk_cntnt"><h4 id="Cy7-3.T.nc_chemical_namecy73s7s26amino5"><a href="/books/NBK132021/table/Cy7-3.T.nc_chemical_namecy73s7s26amino5/?report=objectonly" target="object" rid-ob="figobCy73Tncchemicalnamecy73s7s26amino5">Table</a></h4><p class="float-caption no_bottom_margin">
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<i>In vitro</i>
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Rodents
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</p></div></div><div id="Cy7-3.Background"><h2 id="_Cy7-3_Background_">Background</h2><p>[<a href="/entrez/query.fcgi?cmd=PureSearch&db=pubmed&details_term=Cy7-3" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">PubMed</a>]</p><p>Optical fluorescence imaging is increasingly used to monitor biological functions of specific targets in small animals (<a class="bibr" href="#Cy7-3.REF.1" rid="Cy7-3.REF.1 Cy7-3.REF.2 Cy7-3.REF.3 Cy7-3.REF.4">1-4</a>). However, the intrinsic fluorescence of biomolecules poses a problem when fluorophores that absorb visible light (350–650 nm) are used. Near-infrared (NIR) fluorescence (650–1,000 nm) detection avoids the natural background fluorescence interference of biomolecules, providing a high contrast between target and background tissues in small animals. NIR fluorophores have a wider dynamic range and minimal background fluorescence as a result of reduced scattering compared with visible fluorescence detection. NIR fluorophores also have high sensitivity, attributable to low background fluorescence, and high extinction coefficients, which provide high quantum yields. The NIR region is also compatible with solid-state optical components, such as diode lasers and silicon detectors. NIR fluorescence imaging is a noninvasive alternative to radionuclide imaging in small animals (<a class="bibr" href="#Cy7-3.REF.4" rid="Cy7-3.REF.4 Cy7-3.REF.5">4, 5</a>).</p><p>Prostate-specific membrane antigen (PSMA) is a cell-surface glycoprotein with a molecular weight of ~100 kDa. It is a unique, type II, transmembrane-bound glycoprotein that is overexpressed on prostate tumor cells and in the neovasculature of most solid prostate tumors, but not in the vasculature of normal tissues (<a class="bibr" href="#Cy7-3.REF.6" rid="Cy7-3.REF.6 Cy7-3.REF.7">6, 7</a>). PSMA has also been detected in other tissues such as the kidneys, the proximal small intestine, and the salivary glands (<a class="bibr" href="#Cy7-3.REF.7" rid="Cy7-3.REF.7">7</a>). PSMA was found to have <i>N</i>-acetyl α-linked acidic dipeptidase (NAALADase) or glutamate carboxypeptidase II activity (<a class="bibr" href="#Cy7-3.REF.8" rid="Cy7-3.REF.8">8</a>). PSMA may play an important role in the progression of prostate cancer and glutamatergic neurotransmission, as well as in the absorption of folate (<a class="bibr" href="#Cy7-3.REF.9" rid="Cy7-3.REF.9">9</a>). In the central nervous system, PSMA metabolizes <i>N</i>-acetyl-aspartyl-glutamate, and in the proximal small intestine it removes γ-linked glutamates from poly-γ-glutamate folate and folate hydrolase (<a class="bibr" href="#Cy7-3.REF.7" rid="Cy7-3.REF.7">7</a>). PSMA can be used as a marker for the detection of metastatic cancers with imaging agents. Although a commercially available monoclonal antibody (<sup>111</sup>In-labeled Capromomab pendetide (<sup>111</sup>In-CYT-356)) is in clinical use for the detection of prostate cancer, the results obtained with this antibody are not entirely reliable (<a class="bibr" href="#Cy7-3.REF.10" rid="Cy7-3.REF.10">10</a>). In addition, this IgG antibody has limited access to tumors and also may produce low signal/noise ratios because the target is the intracellular domain of PSMA (<a class="bibr" href="#Cy7-3.REF.11" rid="Cy7-3.REF.11 Cy7-3.REF.12">11, 12</a>). IRDye800CW-(3<i>S</i>,7<i>S</i>)-26-Amino-5,13,20-trioxo-4,6,12,21-tetraazahexacosane-1,3,7,22-tetracarboxylic acid (YC-27, also known as 800CW-3) is a small molecule inhibitor of NAALADase (<a class="bibr" href="#Cy7-3.REF.13" rid="Cy7-3.REF.13">13</a>). YC-27 was able to visualize PSMA-positive tumors in nude mice, but accumulation of signal was high in the kidney. Chen et al. (<a class="bibr" href="#Cy7-3.REF.14" rid="Cy7-3.REF.14">14</a>) evaluated a series of dye-3 conjugates with Cy5.5, IGC, IRDye800RS, and Cy7 in nude mice bearing human PSMA-positive xenografts. Injected Cy7-3 exhibited good tumor accumulation with lower liver and kidney accumulation than YC-27.</p><div id="Cy7-3.Related_Resource_Links"><h3>Related Resource Links:</h3><ul><li class="half_rhythm"><div>Chapters in MICAD (<a href="/sites/entrez?Db=books&Cmd=DetailsSearch&Term=PSMA+AND+micad%5Bbook%5D" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">PSMA</a>)</div></li><li class="half_rhythm"><div>Gene information in NCBI (<a href="/sites/entrez?Db=gene&Cmd=DetailsSearch&Term=2346" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">PSMA</a>)</div></li><li class="half_rhythm"><div>Articles in OMIM Articles in Online Mendelian Inheritance in Man (OMIM) (<a href="http://omim.org/entry/602640" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">PSMA</a>)</div></li><li class="half_rhythm"><div>Clinical trials (<a href="http://www.clinicaltrials.gov/ct2/results?term=PSMA" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">PSMA</a>)</div></li></ul></div></div><div id="Cy7-3.Synthesis"><h2 id="_Cy7-3_Synthesis_">Synthesis</h2><p>[<a href="/entrez/query.fcgi?cmd=PureSearch&db=pubmed&details_term=Cy7-3%20AND%20synthesis" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">PubMed</a>]</p><p><i>N</i>,<i>N</i>-Diisopropylethylamine (0.0115 mM) was added to a solution of compound 3 (710 nmol) in dimethyl sulfoxide, followed by <i>N</i>-hydroxysuccininide ester of Cy7 (610 nM) (<a class="bibr" href="#Cy7-3.REF.14" rid="Cy7-3.REF.14">14</a>). The mixture was incubated at room temperature for 2 h. Cy7-3 was purified with high-performance liquid chromatography with 64% yield. The molecular weight of Cy7-3 (1.27 kDa) with one Cy7 per targeting molecule was confirmed with mass spectroscopy. Cy7-3 exhibited an absorbance maximum at 743 nm and an emission maximum at 767 nm.</p></div><div id="Cy7-3.In_Vitro_Studies_Testing_in_Cells"><h2 id="_Cy7-3_In_Vitro_Studies_Testing_in_Cells_"><i>In Vitro</i> Studies: Testing in Cells and Tissues</h2><p>[<a href="/entrez/query.fcgi?cmd=PureSearch&db=pubmed&details_term=Cy7-3%20AND%20in%20vitro" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">PubMed</a>]</p><p>The binding affinity of Cy7-3 for PSMA was determined with the use of a NAALADase assay (<a class="bibr" href="#Cy7-3.REF.14" rid="Cy7-3.REF.14">14</a>). Cy7-3 exhibited an inhibition constant (<i>K</i><sub>i</sub>) value of 5.0 ± 0.2 nM. The <i>K</i><sub>i</sub> value of 800CW-3 was 20 ± 5 nM.</p></div><div id="Cy7-3.Animal_Studies"><h2 id="_Cy7-3_Animal_Studies_">Animal Studies</h2><div id="Cy7-3.Rodents"><h3>Rodents</h3><p>[<a href="/entrez/query.fcgi?cmd=PureSearch&db=pubmed&details_term=Cy7-3%20and%20rodentia" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">PubMed</a>]</p><p>Chen et al. (<a class="bibr" href="#Cy7-3.REF.14" rid="Cy7-3.REF.14">14</a>) performed NIR fluorescence imaging studies of Cy7-3 or YC-27 (1 nmol) in nude mice (<i>n</i> = 3) bearing PSMA-positive PC3-PIP tumor xenografts and PSMA-negative PC3-flu tumor xenografts. The PC3-PIP tumors were clearly visualized at 24 h after injection of the tracers. On the other hand, the NIR signal from the PC3-flu tumors was weak. Kidney accumulation of fluorescence was more prominent for YC-27 than Cy7-3. The tumor/kidney ratio for Cy7-3 was higher than that for YC-27. <i>Ex vivo</i> NIR imaging showed that the PC3-PIP tumors exhibited higher fluorescence intensity than the kidneys, liver, spleen, intestines, and PC3-flu tumors for Cy7-3. Co-injection of 1 nmol Cy7-3 with 1,000 nmol DClBzL (a PSMA inhibitor) in mice bearing the two tumors inhibited the NIR fluorescence in the PC3-PIP tumors nearly to the background level of the PC3-flu tumors at 24 h after injection. The <i>ex vivo</i> NIR signals in the tumors were consistent with the <i>in vivo</i> imaging.</p></div><div id="Cy7-3.Other_NonPrimate_Mammals"><h3>Other Non-Primate Mammals</h3><p>[<a href="/entrez/query.fcgi?cmd=PureSearch&db=pubmed&details_term=Cy7-3%20AND%20%28dog%20OR%20rabbit%20OR%20pig%20OR%20sheep%29" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">PubMed</a>]</p><p>No publication is currently available.</p></div><div id="Cy7-3.NonHuman_Primates"><h3>Non-Human Primates</h3><p>[<a href="/entrez/query.fcgi?cmd=PureSearch&db=pubmed&details_term=YC-27%20AND%20Primates" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">PubMed</a>]</p><p>No publication is currently available.</p></div></div><div id="Cy7-3.Human_Studies"><h2 id="_Cy7-3_Human_Studies_">Human Studies</h2><p>[<a href="/entrez/query.fcgi?cmd=PureSearch&db=pubmed&details_term=Cy7-3%20AND%20human" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">PubMed</a>]</p><p>No publication is currently available.</p></div><div id="Cy7-3.NIH_Support"><h2 id="_Cy7-3_NIH_Support_">NIH Support</h2><p>R01 CA134675</p></div><div id="Cy7-3.References"><h2 id="_Cy7-3_References_">References</h2><dl class="temp-labeled-list"><dl class="bkr_refwrap"><dt>1.</dt><dd><div class="bk_ref" id="Cy7-3.REF.1">Achilefu S.
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<em>Lighting up tumors with receptor-specific optical molecular probes.</em>
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<span><span class="ref-journal">Technol Cancer Res Treat. </span>2004;<span class="ref-vol">3</span>(4):393–409.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/15270591" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 15270591</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>2.</dt><dd><div class="bk_ref" id="Cy7-3.REF.2">Ntziachristos V., Bremer C., Weissleder R.
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<em>Fluorescence imaging with near-infrared light: new technological advances that enable in vivo molecular imaging.</em>
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<span><span class="ref-journal">Eur Radiol. </span>2003;<span class="ref-vol">13</span>(1):195–208.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/12541130" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 12541130</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>3.</dt><dd><div class="bk_ref" id="Cy7-3.REF.3">Becker A., Hessenius C., Licha K., Ebert B., Sukowski U., Semmler W., Wiedenmann B., Grotzinger C.
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<em>Receptor-targeted optical imaging of tumors with near-infrared fluorescent ligands.</em>
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<span><span class="ref-journal">Nat Biotechnol. </span>2001;<span class="ref-vol">19</span>(4):327–31.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/11283589" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 11283589</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>4.</dt><dd><div class="bk_ref" id="Cy7-3.REF.4">Leung K., Chopra A., Shan L., Eckelman W.C., Menkens A.E.
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<em>Essential parameters to consider for the characterization of optical imaging probes.</em>
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<span><span class="ref-journal">Nanomedicine (Lond). </span>2012;<span class="ref-vol">7</span>(7):1101–7.</span> [<a href="/pmc/articles/PMC3445333/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC3445333</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/22846094" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 22846094</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>5.</dt><dd><div class="bk_ref" id="Cy7-3.REF.5">Tung C.H.
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<em>Fluorescent peptide probes for in vivo diagnostic imaging.</em>
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<span><span class="ref-journal">Biopolymers. </span>2004;<span class="ref-vol">76</span>(5):391–403.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/15389488" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 15389488</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>6.</dt><dd><div class="bk_ref" id="Cy7-3.REF.6">Feneley M.R., Jan H., Granowska M., Mather S.J., Ellison D., Glass J., Coptcoat M., Kirby R.S., Ogden C., Oliver R.T., Badenoch D.F., Chinegwundoh F.I., Nargund V.H., Paris A.M., Britton K.E.
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<em>Imaging with prostate-specific membrane antigen (PSMA) in prostate cancer.</em>
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<span><span class="ref-journal">Prostate Cancer Prostatic Dis. </span>2000;<span class="ref-vol">3</span>(1):47–52.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/12497162" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 12497162</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>7.</dt><dd><div class="bk_ref" id="Cy7-3.REF.7">Ghosh A., Heston W.D.
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<em>Tumor target prostate specific membrane antigen (PSMA) and its regulation in prostate cancer.</em>
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<span><span class="ref-journal">J Cell Biochem. </span>2004;<span class="ref-vol">91</span>(3):528–39.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/14755683" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 14755683</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>8.</dt><dd><div class="bk_ref" id="Cy7-3.REF.8">Luthi-Carter R., Barczak A.K., Speno H., Coyle J.T.
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<em>Molecular characterization of human brain N-acetylated alpha-linked acidic dipeptidase (NAALADase).</em>
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<span><span class="ref-journal">J Pharmacol Exp Ther. </span>1998;<span class="ref-vol">286</span>(2):1020–5.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/9694964" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 9694964</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>9.</dt><dd><div class="bk_ref" id="Cy7-3.REF.9">O'Keefe D.S., Uchida A., Bacich D.J., Watt F.B., Martorana A., Molloy P.L., Heston W.D.
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<em>Prostate-specific suicide gene therapy using the prostate-specific membrane antigen promoter and enhancer.</em>
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<span><span class="ref-journal">Prostate. </span>2000;<span class="ref-vol">45</span>(2):149–57.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/11027414" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 11027414</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>10.</dt><dd><div class="bk_ref" id="Cy7-3.REF.10">Ponsky L.E., Cherullo E.E., Starkey R., Nelson D., Neumann D., Zippe C.D.
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<em>Evaluation of preoperative ProstaScint scans in the prediction of nodal disease.</em>
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<span><span class="ref-journal">Prostate Cancer Prostatic Dis. </span>2002;<span class="ref-vol">5</span>(2):132–5.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/12497003" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 12497003</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>11.</dt><dd><div class="bk_ref" id="Cy7-3.REF.11">Jain R.K.
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<em>Transport of molecules, particles, and cells in solid tumors.</em>
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<span><span class="ref-journal">Annu Rev Biomed Eng. </span>1999;<span class="ref-vol">1</span>:241–63.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/11701489" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 11701489</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>12.</dt><dd><div class="bk_ref" id="Cy7-3.REF.12">Sundaresan G., Yazaki P.J., Shively J.E., Finn R.D., Larson S.M., Raubitschek A.A., Williams L.E., Chatziioannou A.F., Gambhir S.S., Wu A.M.
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<em>124I-labeled engineered anti-CEA minibodies and diabodies allow high-contrast, antigen-specific small-animal PET imaging of xenografts in athymic mice.</em>
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<span><span class="ref-journal">J Nucl Med. </span>2003;<span class="ref-vol">44</span>(12):1962–9.</span> [<a href="/pmc/articles/PMC4167879/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC4167879</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/14660722" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 14660722</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>13.</dt><dd><div class="bk_ref" id="Cy7-3.REF.13">Chen Y., Dhara S., Banerjee S.R., Byun Y., Pullambhatla M., Mease R.C., Pomper M.G.
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<em>A low molecular weight PSMA-based fluorescent imaging agent for cancer.</em>
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<span><span class="ref-journal">Biochem Biophys Res Commun. </span>2009;<span class="ref-vol">390</span>(3):624–9.</span> [<a href="/pmc/articles/PMC2787846/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC2787846</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/19818734" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 19818734</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>14.</dt><dd><div class="bk_ref" id="Cy7-3.REF.14">Chen Y., Pullambhatla M., Banerjee S.R., Byun Y., Stathis M., Rojas C., Slusher B.S., Mease R.C., Pomper M.G.
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<em>Synthesis and biological evaluation of low molecular weight fluorescent imaging agents for the prostate-specific membrane antigen.</em>
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<span><span class="ref-journal">Bioconjug Chem. </span>2012;<span class="ref-vol">23</span>(12):2377–85.</span> [<a href="/pmc/articles/PMC4131203/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC4131203</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/23157641" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 23157641</span></a>]</div></dd></dl></dl></div><div id="bk_toc_contnr"></div></div></div><div class="fm-sec"><h2 id="_NBK132021_pubdet_">Publication Details</h2><h3>Author Information and Affiliations</h3><div class="contrib half_rhythm"><span itemprop="author">Kam Leung</span>, PhD<div class="affiliation small">National Center for Biotechnology Information, NLM, NIH, Bethesda, MD<div><span class="email-label">Email: </span><a href="mailto:dev@null" data-email="vog.hin.mln.ibcn@DACIM" class="oemail">vog.hin.mln.ibcn@DACIM</a></div></div><div class="small">Corresponding author.</div></div><h3>Publication History</h3><p class="small">Created: <span itemprop="datePublished">December 27, 2012</span>; Last Update: <span itemprop="dateModified">April 4, 2013</span>.</p><h3>Copyright</h3><div><div class="half_rhythm"><a href="/books/about/copyright/">Copyright Notice</a></div></div><h3>Publisher</h3><p><a href="http://www.ncbi.nlm.nih.gov/" ref="pagearea=page-banner&targetsite=external&targetcat=link&targettype=publisher">National Center for Biotechnology Information (US)</a>, Bethesda (MD)</p><h3>NLM Citation</h3><p>Leung K. Cy7-(3S,7S)-26-Amino-5,13,20-trioxo-4,6,12,21-tetraazahexacosane-1,3,7,22-tetracarboxylic acid. 2012 Dec 27 [Updated 2013 Apr 4]. In: Molecular Imaging and Contrast Agent Database (MICAD) [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2004-2013. <span class="bk_cite_avail"></span></p></div><div class="small-screen-prev"><a href="/books/n/micad/soscy7/?report=reader"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 100 100" preserveAspectRatio="none"><path d="M75,30 c-80,60 -80,0 0,60 c-30,-60 -30,0 0,-60"></path><text x="20" y="28" textLength="60" style="font-size:25px">Prev</text></svg></a></div><div class="small-screen-next"><a href="/books/n/micad/DPA-Zn-Cy7/?report=reader"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 100 100" preserveAspectRatio="none"><path d="M25,30c80,60 80,0 0,60 c30,-60 30,0 0,-60"></path><text x="20" y="28" textLength="60" style="font-size:25px">Next</text></svg></a></div></article><article data-type="table-wrap" id="figobCy73Tncchemicalnamecy73s7s26amino5"><div id="Cy7-3.T.nc_chemical_namecy73s7s26amino5" class="table"><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK132021/table/Cy7-3.T.nc_chemical_namecy73s7s26amino5/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__Cy7-3.T.nc_chemical_namecy73s7s26amino5_lrgtbl__"><table><tbody><tr><td rowspan="1" colspan="1" style="text-align:right;vertical-align:top;">
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<b>Chemical name:</b>
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</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Cy7-(3<i>S</i>,7<i>S</i>)-26-Amino-5,13,20-trioxo-4,6,12,21-tetraazahexacosane-1,3,7,22-tetracarboxylic acid</td><td rowspan="9" colspan="1" style="text-align:center;vertical-align:middle;"></td></tr><tr><td rowspan="1" colspan="1" style="text-align:right;vertical-align:top;">
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<b>Abbreviated name:</b>
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</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Cy7-3</td></tr><tr><td rowspan="1" colspan="1" style="text-align:right;vertical-align:top;">
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<b>Synonym:</b>
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</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td></tr><tr><td rowspan="1" colspan="1" style="text-align:right;vertical-align:top;">
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<b>Agent category:</b>
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</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Compound</td></tr><tr><td rowspan="1" colspan="1" style="text-align:right;vertical-align:top;">
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<b>Target:</b>
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</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Prostate-specific membrane antigen (PSMA), or <i>N</i>-acetyl α-linked acidic dipeptidase (NAALADase)</td></tr><tr><td rowspan="1" colspan="1" style="text-align:right;vertical-align:top;">
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<b>Target category:</b>
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</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Antigen</td></tr><tr><td rowspan="1" colspan="1" style="text-align:right;vertical-align:top;">
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<b>Method of detection:</b>
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</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Optical, near-infrared fluorescence (NIR) imaging</td></tr><tr><td rowspan="1" colspan="1" style="text-align:right;vertical-align:top;">
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<b>Source of signal:</b>
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</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Cy7</td></tr><tr><td rowspan="1" colspan="1" style="text-align:right;vertical-align:top;">
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<b>Activation:</b>
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</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">No</td></tr><tr><td rowspan="1" colspan="1" style="text-align:right;vertical-align:top;">
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<b>Studies:</b>
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</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<ul class="simple-list"><li class="half_rhythm"><div>
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<img alt="Checkbox" src="/corehtml/pmc/css/bookshelf/2.26/img/studies.checkbox.png" />
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<i>In vitro</i>
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</div></li><li class="half_rhythm"><div>
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<img alt="Checkbox" src="/corehtml/pmc/css/bookshelf/2.26/img/studies.checkbox.png" /> Rodents
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</div></li></ul>
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</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Click on <a href="/entrez/viewer.fcgi?db=protein&val=4758398" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">protein</a>, <a href="/entrez/viewer.fcgi?db=nucleotide&val=4758397" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">nucleotide</a> (RefSeq), and <a href="/entrez/query.fcgi?db=gene&cmd=Retrieve&dopt=full_report&list_uids=2346" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">gene</a> for more information about PSMA.</td></tr></tbody></table></div></div></article></div><div id="jr-scripts"><script src="/corehtml/pmc/jatsreader/ptpmc_3.22/js/libs.min.js"> </script><script src="/corehtml/pmc/jatsreader/ptpmc_3.22/js/jr.min.js"> </script></div></div>
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